検索結果

Search Results for " covalent "

ターゲット

318

阻害剤

天然化合物

リコンビナントタンパク質

ライブラリー

カタログ番号	製品名	別名	ターゲット
T11709	JAK3 covalent inhibitor-1		JAK
	JAK3 Covalent Inhibitor-1 is a compound characterized by its potent and selective inhibition of Janus kinase 3 (JAK3), possessing an IC50 of 11 nM and demonstrating a 246-fold selectivity compared to other JAKs.		JAK
T41277	PACMA 31		Others
	PACMA 31 is an irreversible and covalent inhibitor of protein disulfide isomerase (PDI) with an IC50 of 10 μM. PACMA 31 significantly suppresses ovarian tumor growth and exhibits tumor targeting ability.		Others
T16143	MRTX-1257		Ras
	MRTX-1257 is a selective, irreversible, and covalent inhibitor of KRAS G12C. It has an IC50 of 900 pM for KRAS dependent ERK phosphorylation in H358 cells. MRTX1257 demonstrated 31% bioavailability in the mouse, with fre...		Ras
T3583	Macozinone	PBTZ169	Antibacterial , DprE1
	Macozinone (PBTZ169) inhibits decaprenylphosphoryl-β-d-ribose 2′-oxidase (DprE1), more efficiently than BTZ043.		Antibacterial , DprE1
T7414	ARS-853		Apoptosis , Raf , Ras
	ARS-853 is an inhibitor of K-RASG12C(IC50 : 2.5 μM), a mutant form of K-RAS that accumulates in the active GTP-bound state in certain cancer cells		Apoptosis , Raf , Ras
T8371	ML188		Virus Protease , SARS-CoV
	ML188 is a selective noncovalent SARS-CoV 3CLpro inhibitor(IC50 : 1.5 μM), with moderate MW and good enzyme and antiviral inhibitory activity.		Virus Protease , SARS-CoV
T9061	EN4	EN4 MYC inhibitor	c-Myc
	EN4 (EN4 MYC inhibitor) MYC inhibitor is a covalent ligand that targets cysteine 171 (C171) of MYC. It is selective for c-MYC over N-MYC and L-MYC, and inhibits MYC transcriptional activity, downregulates MYC targets, an...		c-Myc
T8684	Sotorasib	AMG-510	Ras
	Sotorasib (AMG-510) is an orally active and selective covalent inhibitor of KRAS G12C. Sotorasib binds to the GDP state of the inactive conformation of KRAS G12C and inhibits KRAS and its downstream signaling. Sotorasib ...		Ras
T22461	YKL-5-124		CDK
	YKL-5-124, a potent, selective and covalent CDK7 inhibitor with an IC50 of 9.7 nM, 1300 nM and 3020 nM for CDK7/Mat1/CycH, CDK2 and CDK9 respectively, displays biochemical and cellular selectivity for CDK7 over CDK12/13...		CDK
T8375	ML-210	CID 49766530	Ferroptosis , GPX , Glutathione Peroxidase , Ras
	ML-210 (CID 49766530) is a selective RAS and covalent glutathione peroxidase 4 (GPX4) inhibitor(GPX4, EC50 : 30 nM), with anti-cancer activity		Ferroptosis , GPX , Glutathione Peroxidase , Ras
T8926	Salcaprozate sodium	SNAC	Others
	Salcaprozate sodium (SNAC), an oral absorption promoter, serves as a potent delivery agent for oral heparin and insulin by enhancing passive transcellular permeation through small intestinal epithelia. This is achieved t...		Others
T8369	Adagrasib	MRTX849	Ras
	Adagrasib (MRTX849) is an orally active and selective covalent inhibitor of KRAS G12C. Adagrasib binds to the GDP state of the inactive conformation of KRAS G12C and inhibits KRAS and its downstream signaling. Adagrasib ...		Ras
T10460	Batabulin	T138067	Apoptosis , Microtubule Associated
	Batabulin (T138067) is an antitumor compound, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Batabulin affects cell morphology and leads to ce...		Apoptosis , Microtubule Associated
T8421	TED-347		YAP
	TED-347 is an irreversible and covalent inhibitor of TEAD4-Yap1 protein-protein interaction(EC50 of 5.9 μM), and inhibits glioblastoma cell viability.		YAP
T10898	Samuraciclib hydrochloride	ICEC0942 hydrochloride,CT7001 hydrochloride	Apoptosis , CDK
	Samuraciclib hydrochloride (ICEC0942 hydrochloride) is a potent, selective, ATP competitive and oral active CDK7 inhibitor with IC50 of 41 nM. The selectivity of Samuraciclib hydrochloride is 45-, 15-, 230- and 30-fold h...		Apoptosis , CDK
T2256	CNX-1351		PI3K
	CNX-1351 is a potent and isoform-selective targeted covalent PI3Kα inhibitor.		PI3K
T79659	SARS-CoV-2 3CLpro-IN-16		SARS-CoV
	SARS-CoV-2 3CLpro-IN-16 is a covalent SARS-CoV-2 3CLpro inhibitor that inhibits 3CLpro activity and achieves its inhibitory effect by forming a covalent bond with Cys145.		SARS-CoV
T7609	ARS-1620		Ras
	ARS-1620 is a covalent inhibitor of K-RASG12C.		Ras
T17029	Tegobuvir	GS-9190,GS 333126	HCV Protease
	Tegobuvir (GS 333126) is a specific and covalent HCV NS5B polymerase inhibitor.		HCV Protease
T60096	EN106	ZINC3888023	Others
	EN106, a potent FEM1B inhibitor and a cysteine-reactive covalent ligand, effectively disrupts the recognition of FEM1B's crucial reductive stress substrate, FNIP1.		Others
T5154	C-176	C176,STING inhibitor 1	STING
	C-176 (STING inhibitor 1) is a strong, covalent mouse STING inhibitor		STING
T13044	Mevociclib	SY-1365	CDK
	Mevociclib (SY-1365) is a highly selective covalent inhibitor of CDK7. SY-1365 possesses therapeutic potential in both hematological and solid tumors.		CDK
T4736	Cruzain-IN-1	ML092	Antibiotic
	Cruzain-IN-1 (ML092) is a covalent and reversible Cruzain inhibitor (IC50: 10 nM).		Antibiotic
T67933	BAY-4931		PPAR
	BAY-4931 is a powerful, covalent, and selective inverse-agonist of PPARγ, exhibiting an IC50 value of 0.17 nM.		PPAR
T16515	PF 750	PF-750,UNII-7756CPP14K,ZINC27647189	FAAH
	PF 750 (ZINC27647189) is a selective and covalent inhibitor of FAAH. PF 750 shows IC50s varying from 16.2 to 595 nM in different incubation times.		FAAH
T3664	THZ1	CDK7 inhibitor,THZ1 2HCl	CDK
	THZ1 (CDK7 inhibitor) is a novel selective and potent covalent CDK7 inhibitor.		CDK
T4293	THZ531		CDK
	THZ531 is a covalent inhibitor of both CDK12(IC50=158 nM) and CDK13(IC50=69 nM).		CDK
T11469	GSK-3484862		DNA Methyltransferase
	GSK-3484862 is a non-covalent Dnmt1 inhibitor. It induces DNA hypomethylation to against cancer.		DNA Methyltransferase
T27319	FIIN-4	FIIN4	FGFR
	FIIN-4 is a covalent inhibitor of FGFR and can be used in studies about metastatic breast cancer.		FGFR
T15793	Lurbinectedin	PM01183	Others
	Lurbinectedin (PM01183) is a DNA minor groove covalent binder. Lurbinectedin also shows effective anti-tumor activity.		Others
T15351	FT827		DUB
	FT827 is a covalent inhibitor of selective ubiquitin-specific protease 7 (USP7) (Ki=4.2 µM, Kd=7.8 µM) targeting the catalytic center of the autoinhibitory apolipoprotein form of USP7 for cancer research.		DUB
T9303	MRTX1133		Ras
	MRTX1133 is a KRAS G12D inhibitor (KD=0.2 pM) that is potent, selective, and non-covalent. MRTX1133 exhibits inhibitory activity against KRAS G12D-mutated tumors, but not against KRAS wild-type tumors.		Ras
T12542	Rilzabrutinib	PRN1008	EGFR , Others , HER , BTK
	Rilzabrutinib (PRN1008) is a reversible covalent, selective and oral active inhibitor of Bruton’s Tyrosine Kinase (BTK)(IC50 of 1.3 nM).		EGFR , Others , HER , BTK
T8427	Borussertib		Akt
	Borussertib is a covalent-allosteric and first-in-class inhibitor of protein kinase Akt(IC50 of 0.8 nM and a Ki of 2.2 nM for Aktwt)		Akt
T22306	DGY-06-116		FGFR , Src
	DGY-06-116 is an selective and irreversible covalent inhibitor of Src and FGFR1 with IC50 value of 3nM and 8340 nM, respectively.		FGFR , Src
T5407	Branebrutinib	BMS986195	BTK
	Branebrutinib (BMS986195) is a potent, covalent inhibitor of Bruton's tyrosine kinase (BTK), >5,000-fold selective over all kinases outside of the Tec family (IC50 <1 nM for BTK).		BTK
T22372	MYF-01-37	1-[3-Methyl-3-[3-(trifluoromethyl)anilino]pyrrolidin-1-yl]prop-2-en-1-one	Others , YAP
	MYF-01-37 (1-[3-Methyl-3-[3-(trifluoromethyl)anilino]pyrrolidin-1-yl]prop-2-en-1-one) is a novel covalent TEAD inhibitor.		Others , YAP
T5199	COH000		E1/E2/E3 Enzyme
	COH000 is a covalent and irreversible inhibitor of small ubiquitin-like modifier (SUMO)-activating enzyme and inhibited SUMOylation (IC50: ~ 0.2 μM in vitro).		E1/E2/E3 Enzyme
T5825	Iadademstat dihydrochloride	ORY-1001(trans)	Histone Demethylase
	Iadademstat dihydrochloride (ORY-1001(trans)) , a Potent and Selective Covalent KDM1A/LSD1 Inhibitor, for the Treatment of Acute Leukemia.		Histone Demethylase
T8569	DMH-25		mTOR
	DMH25 is a novel covalent and potent inhibitor of mTOR and shows in vivo antitumor activity against triple-negative breast cancer cells.		mTOR
T24827	SR 16832	SR-16832,SR16832	PPAR
	SR 16832 is a dual-site PPARγ inhibitor. It also inhibits the binding of endogenous ligands and transcriptional activity of PPARγ, more effectively than the orthosteric covalent antagonist GW 9662 and T 0070907.		PPAR
T17389	AMAS		Others
	AMAS is a non-claevable heterobifunctional crosslinker with NHS ester and maleimide groups that enables covalent conjugation of amine- and sulfhydryl-containing molecules.		Others
T8431	JCN037		EGFR
	JCN037 is potent, non-covalent and brain-penetrant inhibitor of EGFR(EGFR, p-wtEGFR and pEGFRvⅢ with IC50 of 2.49 nM, 3.95 nM, 4.48 nM , respectively).		EGFR
T7329	C-178		STING
	C-178 is a covalent inhibitor of STING, binds to Cys91 on STING to block its palmitoylation and prevents recruitment and phosphorylation of TBK1 in HEK293T cells.		STING
T60050	ANT3310		Antibacterial
	ANT3310 is an inhibitor of broad-spectrum covalent Serine β-Lactamase with IC50s ranging from 1 nM to 175 nM for AmpC, CTX-M-15, TEM-1, OXA-48, OXA-23, and KPC-2. ANT3310 can be used in studies about bacterial infection.		Antibacterial
T11724	JNJ-42226314		Lipase
	JNJ-42226314 is a highly selective non-covalent monoacylglycerol lipase (MAGL) inhibitor with anti-injury effects.JNJ-42226314 shows efficacy via endogenous cannabinoid-2-acryloylglycerol (2-AG) in models of neuropathic ...		Lipase
T9529	TAK-020		BTK
	TAK-020 is a potent covalent inhibitor of Btk with potential antitumor activity for the study of rheumatoid arthritis and immune-related diseases.		BTK
T9203	JH-X-119-01		IRAK
	JH-X-119-01 is a highly potent and selective covalent inhibitor of IRAK-1.		IRAK
T10188	6RK73		Others
	6RK73 is a covalent irreversible and specific UCHL1 inhibitor (IC50: 0.23 µM). 6RK73 shows almost no inhibition of UCHL3 (IC50: 236 µM).		Others
T5091	FM-381	FM381	JAK
	FM381 is a potent covalent reversible inhibitor of JAK3. FM-381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively.		JAK

Compounds

JAK3 covalent inhibitor-1

Target: Antibacterial, DprE1

ARS-853

T7414

Synonym:

Target: Apoptosis, Raf, Ras

ML188

T8371

Synonym:

Target: Virus Protease, SARS-CoV

EN4

T9061

Synonym: EN4 MYC inhibitor

Synonym: CID 49766530

Target: Ferroptosis, GPX, Glutathione Peroxidase, Ras

Target: Apoptosis, Microtubule Associated

Samuraciclib hydrochloride

T10898

Synonym: ICEC0942 hydrochloride,CT7001 hydrochloride

Target: Apoptosis, CDK

SARS-CoV-2 3CLpro-IN-16

Synonym: GS-9190,GS 333126

Synonym: C176,STING inhibitor 1

Synonym: PF-750,UNII-7756CPP14K,ZINC27647189

Target: FAAH

THZ1

T3664

Synonym: CDK7 inhibitor,THZ1 2HCl

Target: DNA Methyltransferase

Target: EGFR, Others, HER, BTK

Synonym: 1-[3-Methyl-3-[3-(trifluoromethyl)anilino]pyrrolidin-1-yl]prop-2-en-1-one

Target: E1/E2/E3 Enzyme

Iadademstat dihydrochloride

T5825

Synonym: ORY-1001(trans)

Target: Histone Demethylase

Synonym: SR-16832,SR16832

Target: Antibacterial

カタログ番号	製品名	別名	ターゲット
T8307	Hydroxy-α-sanshool	Hydroxy-α-sanshool	Endogenous Metabolite , TRP/TRPV Channel
	Hydroxy-α-sanshool is an alkyl amide isolated from the pepper. It acts as a TRPA1 covalent and TRPV1 non-covalent agonist (EC50s: 69 and 1.1 μM).		Endogenous Metabolite , TRP/TRPV Channel
TN1620	Eriocalyxin B		Apoptosis , cAMP , NF-κB , STAT
	Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways, should be considered a candidate for pancreatic cancer treatment; it is a specific inh...		Apoptosis , cAMP , NF-κB , STAT
T4889	2,6-Diaminoheptanedioic acid		Others , Endogenous Metabolite
	Diaminopimelic acid or DAPA is a lysine-like amino acid derivative that is a key component of the bacterial cell wall. DAPA is incorporated or integrated into peptidoglycan of gram negative bacteria and is the attachment...		Others , Endogenous Metabolite
T11555	Heptasaccharide Glc4Xyl3		Others
	Heptasaccharide Glc4Xyl3 is a covalent inhibitor of endo-xyloglucanases. It used for the identification and analysis of diverse xyloglucan-active enzymes in nature.		Others
TN4840	Psoromic acid		Others
	Psoromic acid is a selective and covalent rab-prenylation inhibitor targeting autoinhibited RabGGTase, it shows antibacterial activities against Streptococcus gordonii and Porphyromonas gingivalis, and it is an effective...		Others

天然物製品

Hydroxy-α-sanshool

T8307

Synonym: Hydroxy-α-sanshool

Target: Endogenous Metabolite, TRP/TRPV Channel

Eriocalyxin B

TN1620

Synonym:

Target: Apoptosis, cAMP, NF-κB, STAT

2,6-Diaminoheptanedioic acid

T4889

Synonym:

Target: Others, Endogenous Metabolite

Heptasaccharide Glc4Xyl3

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-02521	HIST3H2A Protein, Human, Recombinant	Human	E. coli
	Histones are a complex family of highly conserved basic proteins responsible for packaging chromosomal DNA into nucleosomes. There are subtype diversities: H1, H2A, H2B, and H3 or H4. It has become more and more evident ...
TMPH-00088	Expansin-B1 Protein, Arabidopsis thaliana, Recombinant (His)	Arabidopsis thaliana	E. coli
	May cause loosening and extension of plant cell walls by disrupting non-covalent bonding between cellulose microfibrils and matrix glucans. No enzymatic activity has been found.
TMPH-00155	Barstar Protein, Bacillus amyloliquefaciens, Recombinant (His & Myc)	Bacillus amyloliquefaciens	E. coli
	Inhibitor of the ribonuclease barnase. Forms a one-to-one non-covalent complex. Barstar Protein, Bacillus amyloliquefaciens, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. ...
TMPH-00108	UBC11 Protein, Arabidopsis thaliana, Recombinant (His)	Arabidopsis thaliana	E. coli
	Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. UBC11 Protein, Arabidopsis thaliana, Recombinant...
TMPH-03601	Streptavidin Protein, S. avidinii, Recombinant (His)	Streptomyces avidinii	P. pastoris (Yeast)
	The biological function of streptavidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of streptavidin). Streptavidin Protein, S. avidinii, Recombinant (His) is...
TMPH-00107	UBC10 Protein, Arabidopsis thaliana, Recombinant (His)	Arabidopsis thaliana	E. coli
	Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. UBC10 Protein, Arabidopsis thaliana, Recombinant...
TMPH-00087	Expansin-A1 Protein, Arabidopsis thaliana, Recombinant (His & Myc)	Arabidopsis thaliana	E. coli
	Causes loosening and extension of plant cell walls by disrupting non-covalent bonding between cellulose microfibrils and matrix glucans. No enzymatic activity has been found. Expansin-A1 Protein, Arabidopsis thaliana, Re...
TMPH-00109	UBC8 Protein, Arabidopsis thaliana, Recombinant (His & Myc)	Arabidopsis thaliana	E. coli
	Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. UBC8 Protein, Arabidopsis thaliana, Recombinant ...
TMPH-03613	NblA Protein, Synechococcus elongatus, Recombinant (His & Myc)	Synechococcus elongatus	E. coli
	Involved in phycobilisome (PBS) degradation during nutrient deprivation. May mark the PBS for degradation by covalent association with PBS components or may disrupt the PBS via ionic interactions. NblA Protein, Synechoco...
TMPJ-01278	SENP8 Protein, Human, Recombinant (His)	Human	E. coli
	Sentrin-Specific Protease 8 (SENP8) mediates the reversible covalent modification of proteins by NEDD8. SENP8 catalyzes the full-length NEDD8 to generate its mature form and deconjugation of NEDD8 from targeted proteins ...
TMPJ-01221	UBE2J2 Protein, Human, Recombinant (GST)	Human	E. coli
	Ubiquitin-Conjugating Enzyme E2 J2 (UBE2J2) belongs to the ubiquitin-conjugating enzyme family. UBE2J2 is involved in the ubiquitiantion. UBE2J2 located in the membrane of the endoplasmic reticulum, catalyzes the covalen...
TMPJ-01198	UBE2R2 Protein, Human, Recombinant (His)	Human	E. coli
	Ubiquitin-Conjugating Enzyme E2 R2 (UBE2R2) is a modification enzyme that belongs to the ubiquitin-conjugating enzyme family. UBE2R2 is involved in cell growth and transformation. It accepts ubiquitin from the E1 complex...
TMPY-02129	Transglutaminase 3/TGM3 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	Transglutaminases (TGase) are a family of calcium-dependent acyl-transfer enzymes ubiquitously expressed in mammalian cells and responsible for catalyzing covalent cross-links between proteins or peptides. Transglutamina...
TMPY-02842	UBE2L6 Protein, Human, Recombinant (His)	Human	E. coli
	UBCH8, also known as UBE2L6, belongs to the ubiquitin-conjugating enzyme family. The family of ubiquitin-conjugating (E2) enzymes is characterized by the presence of a highly conserved ubiquitin-conjugating (UBC) domain....
TMPJ-01334	UBE2Z Protein, Human, Recombinant (His)	Human	E. coli
	Ubiquitin-Conjugating Enzyme E2 Z (ZUBE2Z) is a member of the E2 ubiquitin-conjugating enzyme family. ZUBE2Z is widely expressed in many tissues, with high expression found in the placenta, pancreas, spleen, and testis. ...
TMPJ-00033	UBE2B Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Ubiquitin-Conjugating Enzyme E2 B (UBE2B) is a member of the ubiquitin-conjugating enzyme family. UBE2B accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. It is shown that UBE2...
TMPH-01265	PELI3 Protein, Human, Recombinant (His)	Human	E. coli
	E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Me...
TMPJ-01069	Serpin A1e Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Alpha-1-antitrypsin 1-5(SERPIN A1) is a secreted protein and belongs to the serpin family. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-...
TMPJ-00985	UBE2A Protein, Human, Recombinant (GST, His)	Human	E. coli
	Ubiquitin-Conjugating Enzyme E2 (UBE2A) is a member of the E2 Ubiquitin-Conjugating Enzyme family. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived prot...
TMPJ-01362	UBAP1 Protein, Human, Recombinant (His)	Human	E. coli
	Ubiquitin-Associated Protein 1 (UBAP1) belongs to the UBA domain family. Members of this family are related to ubiquitin and the ubiquitination pathway. Because of their cytogenetic location, this UBA domain family membe...
TMPJ-01403	UBE2D4 Protein, Human, Recombinant (GST)	Human	E. coli
	Ubiquitin-Conjugating Enzyme E2 D4 (UBE2D4) is a ligase that belongs to the Ubiquitin-Conjugating Enzyme family. UBE2D4 has been proposed to participate in Ubl conjugation pathway. UBE2D4 takes part in post-translational...
TMPY-00323	Hepatitis C virus (HCV-1a) NS3 protease/helicase immunodominant region Protein (aa 1356-1459, GST)	HCV	E. coli
	HCV NS3 displays three enzymatic activities: serine protease, NTPase, and RNA helicase. HCV NS3 serine protease, in association with NS4A, is responsible for the cleavages of NS3-NS4A, NS4A-NS4B, NS4B-NS5A, and NS5A-NS5B...
TMPJ-01089	TFF1 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Trefoil Factor 1 (TFF1) belongs to the three structurally related secreted proteins that contain trefoil domains.TFF1 is an approximately peptide that has an important effect in epithelial regeneration and wound healing...
TMPY-03052	MFAP5 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	MFAP5 (Microfibril Associated Protein 5, also known as MAGP2) is a Protein Coding gene. MFAP5 is a component of the elastin-associated microfibrils. It belongs to the MFAP family. As a 25-kD microfibril-associated glycop...
TMPJ-01055	HBA1 Protein, Human, Recombinant (His)	Human	E. coli
	Hemoglobin subunit alpha 1 (HBA1), also known as α2β2, is a hetero-tetramer consisting of two α and two β subunits held together by non-covalent interactions. Each subunit contains a heme group with an iron atom in the F...
TMPJ-00486	SUMO2 Protein, Human, Recombinant (His)	Human	E. coli
	Small Ubiquitin-Related Modifier 2 (SUMO2) is an Ubiquitin-like protein that belongs to the ubiquitin family with SUMO subfamily. It is a family of small, related proteins that can be enzymatically attached to a target p...
TMPY-02642	UBE2W Protein, Human, Recombinant (His)	Human	E. coli
	Ubiquitin-conjugating enzymes, also known as UBE2W, E2 enzymes and more rarely as ubiquitin-carrier enzymes, perform the second step of protein ubiquitination. The modification of protein with ubiquitin is an important c...
TMPH-01241	TOP1 Protein, Human, Recombinant (His & Myc)	Human	Baculovirus Insect Cells
	Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via tran...
TMPJ-01100	UBE2V1 Protein, Human, Recombinant (His)	Human	E. coli
	Ubiquitin-Conjugating Enzyme Variant 1a (UBE2V1) is a member of the Ubiquitin-conjugating (E2) enzyme family. The E2 catalytic core domain of UBE2V1 lacks an active site cysteine residue, rendering it catalytically inact...
TMPH-00651	Lpp Protein, E. coli, Recombinant (His & KSI)	E. coli	E. coli
	An outer membrane lipoprotein that controls the distance between the inner and outer membranes; adding residues to Lpp increases the width of the periplasm. The only protein known to be covalently linked to the peptidogl...
TMPH-01270	TRAIP Protein, Human, Recombinant (His)	Human	E. coli
	E3 ubiquitin ligase required to protect genome stability in response to replication stress. Acts as a key regulator of interstrand cross-link repair, which takes place when both strands of duplex DNA are covalently tethe...
TMPH-01263	PRKN Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Substrates include SYT11 and VDAC1. Other substrates are BCL2, CCNE1, GPR37, ...
TMPH-02631	PRKN Protein, Mouse, Recombinant (GST)	Mouse	E. coli
	Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Substrates include SYT11 and VDAC1. Other substrates are BCL2, CCNE1, GPR37, ...

HIST3H2A Protein, Human, Recombinant

TMPY-02521

Species: Human

Expression System: E. coli

Expansin-B1 Protein, Arabidopsis thaliana, Recombinant (His)

TMPH-00088

Species: Arabidopsis thaliana

Expression System: E. coli

Barstar Protein, Bacillus amyloliquefaciens, Recombinant (His & Myc)

TMPH-00155

Species: Bacillus amyloliquefaciens

Expression System: E. coli

UBC11 Protein, Arabidopsis thaliana, Recombinant (His)

TMPH-00108

Species: Arabidopsis thaliana

Expression System: E. coli

Streptavidin Protein, S. avidinii, Recombinant (His)

TMPH-03601

Species: Streptomyces avidinii

Expression System: P. pastoris (Yeast)

UBC10 Protein, Arabidopsis thaliana, Recombinant (His)

TMPH-00107

Species: Arabidopsis thaliana

Expression System: E. coli

Expansin-A1 Protein, Arabidopsis thaliana, Recombinant (His & Myc)

TMPH-00087

Species: Arabidopsis thaliana

Expression System: E. coli

UBC8 Protein, Arabidopsis thaliana, Recombinant (His & Myc)

TMPH-00109

Species: Arabidopsis thaliana

Expression System: E. coli

NblA Protein, Synechococcus elongatus, Recombinant (His & Myc)

TMPH-03613

Species: Synechococcus elongatus

Expression System: E. coli

SENP8 Protein, Human, Recombinant (His)

TMPJ-01278

Species: Human

Expression System: E. coli

UBE2J2 Protein, Human, Recombinant (GST)

TMPJ-01221

Species: Human

Expression System: E. coli

UBE2R2 Protein, Human, Recombinant (His)

TMPJ-01198

Species: Human

Expression System: E. coli

Transglutaminase 3/TGM3 Protein, Human, Recombinant (His)

TMPY-02129

Species: Human

Expression System: Baculovirus Insect Cells

UBE2L6 Protein, Human, Recombinant (His)

TMPY-02842

Species: Human

Expression System: E. coli

UBE2Z Protein, Human, Recombinant (His)

TMPJ-01334

Species: Human

Expression System: E. coli

UBE2B Protein, Human, Recombinant (His)

TMPJ-00033

Species: Human

Expression System: HEK293 Cells

PELI3 Protein, Human, Recombinant (His)

TMPH-01265

Species: Human

Expression System: E. coli

Serpin A1e Protein, Mouse, Recombinant (His)

TMPJ-01069

Species: Mouse

Expression System: HEK293 Cells

UBE2A Protein, Human, Recombinant (GST, His)

TMPJ-00985

Species: Human

Expression System: E. coli

UBAP1 Protein, Human, Recombinant (His)

TMPJ-01362

Species: Human

Expression System: E. coli

UBE2D4 Protein, Human, Recombinant (GST)

TMPJ-01403

Species: Human

Expression System: E. coli

Hepatitis C virus (HCV-1a) NS3 protease/helicase immunodominant region Protein (aa 1356-1459, GST)

TMPY-00323

Species: HCV

Expression System: E. coli

TFF1 Protein, Mouse, Recombinant (His)

TMPJ-01089

Species: Mouse

Expression System: HEK293 Cells

MFAP5 Protein, Human, Recombinant (His)

TMPY-03052

Species: Human

Expression System: HEK293 Cells

HBA1 Protein, Human, Recombinant (His)

TMPJ-01055

Species: Human

Expression System: E. coli

SUMO2 Protein, Human, Recombinant (His)

TMPJ-00486

Species: Human

Expression System: E. coli

UBE2W Protein, Human, Recombinant (His)

TMPY-02642

Species: Human

Expression System: E. coli

TOP1 Protein, Human, Recombinant (His & Myc)

TMPH-01241

Species: Human

Expression System: Baculovirus Insect Cells

UBE2V1 Protein, Human, Recombinant (His)

TMPJ-01100

Species: Human

Expression System: E. coli

Lpp Protein, E. coli, Recombinant (His & KSI)

TMPH-00651

Species: E. coli

Expression System: E. coli

TRAIP Protein, Human, Recombinant (His)

TMPH-01270

Species: Human

Expression System: E. coli

PRKN Protein, Human, Recombinant (His & SUMO)

TMPH-01263

Species: Human

Expression System: E. coli

PRKN Protein, Mouse, Recombinant (GST)

TMPH-02631

Species: Mouse

Expression System: E. coli

カタログ番号	製品名
L9411	Cysteine Covalent Library	70 compounds
	The cysteine covalent library contains 70 compounds.
L9410	Covalent Inhibitor Library	1920 compounds
	A unique collection of 1920 covalent Inhibitors and other molecules with common warheads like chloroacetyl，2-Chloropropionyl，Acryloyl，sulfonyl fluoride, alkyne，acrylamide, ketocarbonyl，disulfide bond, etc.
L6150	Covalent Natural Product Library	583 compounds
	Detialed biological information and pharmacological information of the products, providing theoretical direction and research basis for screening.
DO2200	Covalent inhibitors Library	12000 compounds

L7860	Mini Electrophilic Heterocyclic Fragment Library	369 compounds
	369 compounds in total in the Highly Solubility Covalent Heterocyclic Fragment Library
L3500	Histone Modification Compound Library	469 compounds
	A unique collection of 469 histone modification related compounds for high throughput screening (HTS) and high content screening (HCS);
L8600	Ubiquitination Compound Library	210 compounds
	A unique collection of 210 ubiquitination related small chemicals can be used for high throughput and high content screening；
L8300	Chromatin Modification Compound Library	250 compounds
	A unique collection of 250 compounds targeting chromatin remodeling pathway for high throughput screening (HTS) and high content screening (HCS);