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T9614 |
MERS-CoV-IN-1
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|
SARS-CoV
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MERS-CoV-IN-1 exhibits excellent inhibitory activity against coronavirus.It is useful as a pharmaceutical composition for preventing coronavirus-induced diseases (MERS-CoV and SARS). |
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T37082 |
HS271
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IRAK
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HS271 is a selective, highly potent and orally active IRAK4 inhibitor (IC50= 7.2 μM). HS271 shows excellent enzymatic and cellular activities, as well as excellent pharmacokinetic properties. |
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T11301L |
Flomoxef sodium
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Others
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Flomoxef sodium, an antibiotic belonging to the oxacephem group, exhibits excellent activity against a broad spectrum of Gram-positive bacteria. |
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T6064 |
UK-383367
|
UK 383367 |
Procollagen C Proteinase
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|
UK-383367 is a procollagen C-proteinase inhibitor with IC50 of 44 nM, has excellent selectivity over MMPs. |
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T1369 |
1-Methylindazole-3-carboxylic acid
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Others
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1-Methylindazole-3-carboxylic acid is an excellent solvent with a proper boiling point. |
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T23602 |
ABC99
|
ABC 99,ABC-99 |
Wnt/beta-catenin
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ABC99 is a selective irreversible inhibitor of the wnt-deacylating enzyme. ABC99 inhibited NOTUM (IC50: 13 nM). It also showed excellent selectivity across the serine hydrolase family. |
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T4278 |
AM966
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LPA Receptor
,
LPL Receptor
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AM966, a excellent affinity, specific, oral LPA1(IC50=17 nM) antagonist, suppresses LPA-stimulated intracellular calcium release. |
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T9810 |
TNIK-IN-5
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|
Wnt/beta-catenin
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TNIK-IN-5 is an potent TNIK inhibitor (IC50= 0.05 μM). TNIK-IN-5 potently inhibits Wnt signaling in intact cells. TNIK-IN-5 exhibits excellent in vitro anti-colorectal cancer activity. |
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T26531 |
ABT-963
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ABT963 |
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ABT-963 is a cyclooxygenase 2 (COX-2) inhibitor potentially for the treatment of osteoarthritis and pain. ABT-963 has excellent selectivity in human whole blood, high oral anti-inflammatory potency in vivo, and gastric s... |
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T19069 |
TMB dihydrochloride
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BM blue dihydrochloride,Sure Blue TMB dihydrochloride,3,3',5,5'-Tetramethylbenzidine dihydrochloride |
Others
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|
TMB dihydrochloride (Sure Blue TMB dihydrochloride) is an enzyme-linked immunosorbent assays (ELISA) and an excellent colorimetric substrate for the detection of horseradish peroxidase (HRP)-labeled probes used in staini... |
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T6080 |
NVP-AEW541
|
AEW541 |
FLT
,
Tyrosine Kinases
,
IGF-1R
,
Autophagy
|
|
NVP-AEW541 (AEW541), a potent inhibitor of IGF-1R(IC50=150 nM) and InsR(IC50=140 nM), exhibits excellent efficiency and specificity for IGF-1R in a cell-based assay. |
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T18978 |
Diphenylterazine
|
DTZ |
Others
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|
Diphenylterazine (DTZ) is a bioluminescent agent. It produces very little background of its own, giving it an excellent signal-to-noise ratio. |
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T12950 |
Sodium laureth sulfate
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Sodium lauryl polyoxyethylene ether sulfate |
Others
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Sodium laureth sulfate (Sodium lauryl polyoxyethylene ether sulfate) is an anionic surfactant, with excellent decontamination, wetting, emulsification, dispersion, solubilizing performance and foaming property. |
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T14386 |
AZD9567
|
Mizacorat |
Glucocorticoid Receptor
|
|
AZD9567 is a potent and orally active and selective non-steroidal glucocorticoid receptor modulator (SGRM) with an IC50 value of 3.8 nM.It has demonstrated excellent efficacy in the Streptococcus cell wall (SCW) reactiva... |
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TP1682L |
Abz-FR-K(Dnp)-P-OH acetate(500799-61-1 free base)
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|
Others
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Abz-FR-K(Dnp)-P-OH acetate is an excellent angiotensin I-converting enzyme (ACE) substrate with a Km value of 4.0 μM and a kcat value of 210s-1. |
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T9508 |
MONOCAPRYLIN
|
Sefsol 318,Glyceryl monocaprylate |
Antibacterial
|
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Monocaprylin (Sefsol 318) is a monoglyceride of caprylic acid with an excellent antibacterial activity. Monocaprylin inhibits a variety of foodborne pathogenic and spoilage microorganisms and has the potential for an alt... |
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T19506 |
PEG400
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Others
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PEG400, a strongly hydrophilic polyethylene glycol, serves as an excellent solvent for a vast array of substances and finds widespread application in numerous pharmaceutical formulations. |
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T9058 |
Bisphenoxyethanolfluorene
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|
Others
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Bisphenoxyethanolfluorene a high stability of the new type of organic chemical raw materials, mainly used for synthesis of heat resistance, excellent transparency and high refractive index of polymer monomer |
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T9048 |
Ecamsule
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Others
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Ecamsule is a benzylidene camphor derivative, many of which are known for their excellent photostability. It can be added to many sunscreens to filter out UVA rays. |
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T11492 |
GSK2983559 free acid
|
|
Others
,
RIP kinase
|
|
GSK2983559 free acid is a specific and orally bioavailable inhibitor of receptor-interacting protein 2 (RIP2) kinase. It has excellent activity in blocking many proinflammatory cytokine responses in vivo and in human inf... |
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T11265 |
Faropenem daloxate
|
Faropenem medoxil |
Antibacterial
,
Antibiotic
|
|
Faropenem daloxate (Faropenem medoxil) is useful for penem and antibiotics. Faropenem medoxomil has excellent in vitro activity against Streptococcus pneumoniae, Haemophilus influenzae and other key pathogens implicated ... |
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T3257 |
UNC0638
|
|
Influenza Virus
,
Histone Methyltransferase
,
Autophagy
|
|
UNC0638 is an inhibitor of β-protein lysine methyltransferases G9a(IC50<15 nM) and GLP(IC50=19 nM) with excellent potency and selectivity over a wide range of epigenetic and non-epigenetic targets. |
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T12731 |
RIPK1-IN-7
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|
RIP kinase
|
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RIPK1-IN-7 is a potent and selective inhibitor of RIPK1(Kd of 4 nM and an enzymatic IC50 of 11 nM),andexhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model. |
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T16116 |
MLN-4760
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RAAS
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MLN-4760 is an angiotensin-converting (ACE2) inhibitor(human ACE2;IC50=0.44 nM). It also has excellent selectivity (>5000-fold) versus related enzymes including human testicular ACE (IC50, >100 μM) and bovine carboxypept... |
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T18983 |
DNP-X acid
|
6-((2,4-Dinitrophenyl)amino)hexanoic acid |
Others
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|
DNP-X acid (6-((2,4-Dinitrophenyl)amino)hexanoic acid) is an amine-reactive building block and can be recognized by anti-DNP antibodies. It is also an excellent amine-reactive FRET quencher paired with Trp or Tyr. |
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T7587 |
Tenapanor
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RDX-5791,RDX 5791,AZD 1722,Tenapanor free base,RDX5791,AZD-1722,AZD1722 |
Sodium Channel
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|
Tenapanor (RDX 5791) is an inhibitor of the sodium-proton (Na(+)/H(+)) exchanger NHE3, which plays a prominent role in sodium handling in the gastrointestinal tract and kidney. Tenapanor possesses an excellent preclinica... |
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T6184 |
Orantinib
|
SU6668,TSU-68,NSC 702827 |
Apoptosis
,
VEGFR
,
FGFR
,
PDGFR
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|
Orantinib (NSC 702827) , a excellent effective against PDGFR autophosphorylation with Ki of 8 nM, also highly inhibits Flk-1 and FGFR1 trans-phosphorylation. It shows little effect against IGF-1R, Met, Src, Lck, Zap70, A... |
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T3978 |
Linerixibat
|
GSK2330672,Iinerixibat |
HBV
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|
Linerixibat (GSK2330672) is a highly effective, nonabsorbable ASBT inhibitor (IC50: 42 ± 3 nM). It can lower glucose in an animal model of type 2 diabetes and shows excellent developability properties. |
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T60129 |
MT189
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Antiproliferative agent-14 |
Microtubule Associated
|
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MT189 (Antiproliferative agent-14) is a potent tubulin polymerization inhibitor, with an IC50 of 3.41 μM. Antiproliferative agent-14 has excellent antiproliferative activity. Antiproliferative agent-14 possess the abilit... |
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T11689 |
ITI-214
|
ITI214 |
PDE
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ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters, and ion channels, exhibits potent PDE1 inhibitory activity (Ki = ... |
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T19671 |
AZ31
|
AZ 31,AZ-31 |
ATM/ATR
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|
AZ31 is an ATM inhibitor with potency, high selectivity, and oral activity.AZ31 inhibits ATM enzymes, intracellular ATM, with IC50 values of <1.2 nM and 46 nM, respectively.AZ31 exhibits excellent ATR selectivity, PIKK f... |
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T34656 |
SKLB 1028
|
Ruserontinib |
EGFR
,
FLT
,
Bcr-Abl
|
|
SKLB 1028 (Ruserontinib) is a new type of oral multikinase inhibitor of EGFR, FLT3, and Abl. SKLB 1028 shows excellent activity in FLT3-driven AML models and considerable potency in CML models containing Abl mutants. |
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T8670 |
Fmoc-L-2-cyanophenylalanine
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|
Others
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fmoc-L-2-cyanophenylalanine is a derivative of the amino acid phenylalanine. Due to its excellent reactivity and stability, it is widely used in peptide synthesis, as well as in the synthesis of a variety of other biolog... |
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T18984 |
DNP-X, SE
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6-(2,4-Dinitrophenyl)aminohexanoic acid, succinimidyl ester |
Others
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|
DNP-X, SE (6-(2,4-Dinitrophenyl)aminohexanoic acid, succinimidyl ester) is an amine-reactive building block and can be recognized by anti-DNP antibodies. DNP-X, SE is also an excellent amine-reactive FRET quencher paired... |
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T16321 |
NI-42
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|
Epigenetic Reader Domain
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NI-42 is a structurally orthogonal chemical probe for the BRPFs and is biased. It effective inhibitor of the BRD of the BRPFs (IC50s of BRPF1/2/3=7.9/48/260 nM; Kds of BRPF1/2/3=40/210/940 nM). It also has excellent sele... |
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T12188 |
NB-360
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|
BACE
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|
|
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T11799 |
L-745870 hydrochloride
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|
Dopamine Receptor
|
|
L-745870 hydrochloride has excellent brain penetration. L-745870 hydrochloride is a high-affinity, selective and orally active human dopamine D4 receptor antagonist with a Ki of 0.43 nM, and considerably weaker D2 recept... |
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T14050 |
5-FAM
|
5-Carboxyfluorescein |
Others
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|
5-FAM (5-Carboxyfluorescein) (5-Carboxyfluorescein) contains a carboxylic acid, which can be used to react with primary amines via carbodiimide activation of the carboxylic acid. Fluorescein is the most common fluorescen... |
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T21395 |
Finerenone
|
BAY948862,BAY-948862,BAY94-8862,BAY 94-8862,BAY-94-8862,BAY 948862 |
Glucocorticoid Receptor
|
|
Finerenone (BAY-948862) is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist with IC50 of 18 nM for the treatment of chronic heart failure. Finerenone (BAY-948862... |
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T20870 |
IR-820
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IR 820,IR820,New Indocyanine Green |
|
|
IR-820 (New Indocyanine Green) is a near-infrared dye with better stability, good color rendering, and excellent fluorescence penetration. IR-820 is an infrared blood pool contrast agent used to detect and quantify disea... |
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T9020 |
GSK620
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|
Epigenetic Reader Domain
|
|
GSK620 is a pan-BD2 inhibitor, which shows an anti-inflammatory phenotype in human whole blood with excellent broad selectivity, developability, and in vivo oral pharmacokinetics.GSK620 is highly selective for the BET-BD... |
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T14878 |
CAY10566
|
|
Dehydrogenase
,
Stearoyl-CoA Desaturase (SCD)
|
|
CAY10566 shows excellent cellular activity in blocking the conversion of saturated long-chain fatty acid-CoAs (LCFA-CoAs) to monounsaturated LCFA-CoAs in HepG2 cells (IC50=7.9 nM or 6.8 nM). CAY10566 is a potent, orally ... |
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T9527 |
Span-85
|
Sorbitan trioleate |
Others
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|
Span-85 (Sorbitan trioleate) is a synthetic non-ionic emulsifier, which is prepared by partial esterification of sorbitol or sorbitan with food grade palmitic acid. It has low viscosity and the smallest HLB value, so it ... |
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T1101 |
Minocycline hydrochloride
|
Minocycline HCl |
HIF/HIF Prolyl-Hydroxylase
,
Antibacterial
,
Antibiotic
|
|
Minocycline hydrochloride (Minocycline HCl) is a tetracycline antibiotic with excellent absorption and tissue penetration that is used for several bacterial infections as well as treatment of acne. Minocycline hydrochlor... |
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T22341 |
GSK-114
|
|
Others
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|
GSK-114, a selective inhibitor of TNNI3 Interacting Kinase (TNNI3K) with IC50 of 25 nM, shows significant bias for TNNI3K over B-Raf with IC50 of 1000 nM, exceptional broad spectrum kinase selectivity and adequate oral e... |
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T61025 |
GSK-1482160
|
|
P2X Receptor
|
|
GSK-1482160 is a CNS-penetrant negative allosteric modulator of P2X7 receptor with oral activity. The P2X7 receptor is involved in the production of pro-inflammatory cytokines by central and peripheral immune cells, so G... |
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T14529 |
Bentiromide
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|
Others
|
|
The bentiromide test is an excellent means of confirming the diagnosis of pancreatic exocrine insufficiency by outpatient test of chymotrypsin function[1]. Bentiromide is a peptide which is broken down in the pancreas by... |
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T30303 |
BAY8040
|
BAY 8040,BAY-8040 |
|
|
BAY8040 is a potent selective human neutrophilic elastase inhibitor with excellent potency and selectivity with promising pharmacokinetic characteristics. |
|
T14296 |
Antitumor agent-3
|
|
Others
|
|
Antitumor agent-3 is a potent compound. It comprises a new imidazopyridine having excellent antitumor activity as an active ingredient. |
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T11301 |
Flomoxef
|
|
Others
|
|
Flomoxef is an antibiotic in oxacephem group and has excellent activity against various gram-positive bacteria. |
