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ターゲット

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天然化合物

リコンビナントタンパク質

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カタログ番号	製品名	別名	ターゲット
T28628	RVX-297	RVX297	Epigenetic Reader Domain
	RVX-297 is a BD2 selective inhibitor of BET bromodomains. RVX-297 preferentially binds to the BD2 domains of the BET bromodomain and Extra Terminal (BET) family of protein.		Epigenetic Reader Domain
T6716	Valsartan	Diovan,Tareg,CGP 48933	RAAS
	Valsartan (CGP 48933) is a tetrazole derivative and angiotensin II type 1 receptor blocker that is used to treat hypertension.		RAAS
T2036	6-OAU	GTPL5846	GPR
	6-OAU (GTPL5846)(GTPL5846; 6-n-octylaminouracil) is a surrogate agonist of GPR84; activates human GPR84 in the presence of Gqi5 chimera in HEK293 cells with an EC50 of 105 nM in the PI assay.		GPR
T4602	Hydrocortisone hemisuccinate	Hydrocortisone 21-he,hydrocortisone 21-hemisuccinate*free acid,Hydrocortisone 21-hemisuccinate	Glucocorticoid Receptor , Others , Interleukin
	Hydrocortisone hemisuccinate (hydrocortisone 21-hemisuccinate*free acid) is a corticosteroid used as an analytical and chromatography reagent.		Glucocorticoid Receptor , Others , Interleukin
T7317	CU-CPT-9a		TLR
	CU-CPT-9a is a potent TLR8 inhibitor (IC50 : 0.5 nM), that suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells-		TLR
T11765	KPLH1130		Dehydrogenase , PDK
	KPLH1130, a specific pyruvate dehydrogenase kinase (PDK) inhibitor, enhances glucose tolerance in mice fed a high-fat diet (HFD). It effectively hinders macrophage polarization and mitigates proinflammatory reactions.		Dehydrogenase , PDK
T11492	GSK2983559 free acid		Others , RIP kinase
	GSK2983559 free acid is a specific and orally bioavailable inhibitor of receptor-interacting protein 2 (RIP2) kinase. It has excellent activity in blocking many proinflammatory cytokine responses in vivo and in human inf...		Others , RIP kinase
T11598	IAXO-102		TLR
	IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling. It inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflammatory protein. IAXO-102 also prevents experimental abdomin...		TLR
T2401	Alogliptin Benzoate	SYR 322,Alogliptin(SYR-322)benzoate	Ferroptosis , Proteasome , DPP-4
	Alogliptin Benzoate (SYR 322)(SYR 322), an effective and specific DPP-4 inhibitor (IC50<10 nM), exhibits greater than 10, 000-fold selectivity over DPP-8/9. Alogliptin may inhibit inflammatory responses by preventing the...		Ferroptosis , Proteasome , DPP-4
T1127	Beclometasone dipropionate	Beclovent,Beclomethasone dipropionate,Beconase,Vancenase	Glucocorticoid Receptor
	Beclometasone dipropionate (Vancenase) is the dipropionate ester of a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and cell entry, beclomethasone...		Glucocorticoid Receptor
T15017	CU-T12-9		TLR
	CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay). It acts by activating the NFkB pathway, upregulating proinflammatory cytokines, and enhancing TLR1 and TLR2 dimerization.CU-T12-9 activat...		TLR
T9543	Syk Inhibitor II hydrochloride		Others
	The impact of spleen tyrosine kinase (Syk) signaling might be prominent in lupus because (i) Syk is a shared downstream signaling molecule among circulating immune complex, LPS, and (1→3)-β-D-glucan (BG), and (ii) all of...		Others
T16570	Pralnacasan	VX-740,HMR 3480	Others
	Pralnacasan inhibits proinflammatory cytokines IL-18, IL-1β , and IFN-γ. Pralnacasan is an effective, non-peptide, and orally active interleukin-1β converting enzyme inhibitor (Ki: 1.4 nM). Pralnacasan has the potential ...		Others
T70484	AD-35
	AD-35 is a neuroprotectant for treating Alzheimer’s diseases by significantly inhibiting the production and release of proinflammatory cytokines TNF-α and IL-1β.
T82467	Endotrophin (Mus musculus)
	Endotrophin (Mus musculus), a cleavage product of collagen 6 (Col6), induces upregulation of profibrotic and proinflammatory genes [1].
T70905	TLR9-IN-18
	TLR9-IN-18 is a potent and selective TLR9 antagonist. TLR9-IN-18 suppresses the production of the proinflammatory cytokine IL-6 in a CpG-induced mouse model.
T68620	(R)-DOI hydrochloride
	(R)-DOI hydrochloride is a 5-HT2 receptor agonist, inhibiting TNF-α-mediated proinflammatory signaling cascades and inflammation via 5-HT2A receptor activation and preventing the development of, and inflammation associat...
T27224	DX-9065A HCl hydrate	DX9065,DX 9065,DX9065A,DX 9065A,DX-9065A,DX-9065
	DX-9065A is a factor Xa inhibitor. DX-9065a inhibits proinflammatory events induced by factor Xa and gingipains. DX-9065a is a competitive inhibitor of the Spectrozyme FXa (SpFXa) cleavage by both fXa and prothrombinase ...
T74572	RIPK2-IN-2
	RIPK2-IN-2 (example 25) is a RIP2 kinase PROTAC inhibitor that effectively blocks RIP2-dependent proinflammatory signaling and regulates RIP2 kinase activity in autoinflammatory diseases [1].
T70015	GSK563
	GSK563 is a potent GVIA iPLA2 inhibitor (XI(50) 0.0000021, IC50 1 nM). GSK563 is 22 000 times more active against GVIA iPLA2 than GIVA cPLA2. It was found to reduce β-cell apoptosis induced by proinflammatory cytokines,...
T72223	Anti-inflammatory agent 7
	Anti-inflammatory Agent 7 suppresses proinflammatory cytokines by hindering the NF-κB/MAPK signaling pathway in both LPS-treated RAW 264.7 cells and mice.
T73580	8A8		NO Synthase
	8A8 is a potent NO inhibitor with proinflammatory factor properties, exhibiting an IC50 of 4.7 μM. Additionally, it significantly inhibits LPS-induced proliferation in HaCat cells [1].		NO Synthase
T36145	12(R)-HETE
	Biosynthesis of 12(R)-HETE in invertebrates is via lipoxygenation of arachidonic acid . In mammals, 12(R)-HETE can be produced by 12(R)-LOs and also by CYP450 oxidation. The activity of 12(R)-HETE in mammals is predomina...
T25976	Ppack HCl	Ppack dihydrochloride,Fprmecl, dihydrochloride
	Ppack HCl is a peptide derivative that irreversibly and specifically suppresses thrombin-mediated platelet activation by binding with high affinity to the active site of thrombin (Ki: 0.24 nM). It has been utilized as an...
T25977	Ppack trifluoroacetate	Ppack trifluoroacetate salt
	Ppack trifluoroacetate is a peptide derivative that irreversibly and specifically suppresses thrombin-mediated platelet activation by binding with high affinity to the active site of thrombin (Ki: 0.24 nM). It has been u...
T79790	ALPK1-IN-3		NF-κB
	ALPK1-IN-3,serves as an ALPK1 inhibitor that dampens proinflammatory gene expression in the kidney and enhances survival in animal models of sepsis-induced acute kidney injury [1].		NF-κB
T61621	IMMH001
	IMMH001, also known as SYL930, is an orally active compound that exhibits potent selectivity as an agonist for the S1P1 receptor, which is the sphingosine-1-phosphate receptor 1. This compound effectively reduces the lev...
T81668	NLRP3 agonist 1		NOD-like Receptor (NLR)
	NLRP3 agonist 1 (compound 23) serves as a potent, orally active agent that activates Caspase-1 enzyme, leading to the cleavage of proinflammatory cytokines pro-IL-1β and pro-IL-18 into their active forms [1].		NOD-like Receptor (NLR)
T71325	ANA-773
	ANA773 is a Toll-like Receptor 7 (TLR7) agonist prodrug with potential immunostimulating activity. Upon oral administration, ANA773 is metabolized into its active form that binds to and activates TLR7, thereby stimulatin...
T71554	ARN 14494
	ARN 14494 is a potent serine palmitoyltransferase inhibitor (SPT; IC50 = 27.3 nM). ARN 14494 inhibits synthesis of long chain ceramides and dihydroceramides in an in vitro model of Alzheimer's diease. The compound preven...
T80759	XY-52
	XY-52 (Compound 32), an ST2 (Stimulation-2) inhibitor, exhibits IC50 values of 5.68 μM and 4.59 μM in the AlphaLISA and HEK-Blue assays, respectively. It promotes proinflammatory T-cell proliferation and diminishes plasm...
T60809	MIF-IN-1
	MIF-IN-1 (compound 14) is a potent inhibitor of macrophage migration inhibitory factor (MIF) with pIC50 of 6.87. Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine associated with multiple disease...
TP1891	MMK 1
	Potent and selective human formyl peptide receptor FPR2 agonist (EC50 values are 1, 2 and > 10 000 nM at mFRP2, hFPR2 and hFPR1 respectively). Induces migration of human monocytes and neutrophils via a chemotactic mechan...
T79637	CIAC001
	CIAC001, a pyruvate kinase PKM2 inhibitor, exhibits anti-neuroinflammatory properties. It effectively suppresses LPS-induced production of proinflammatory nitric oxide (NO) and provides protection to immunologically acti...
T73527	GK563
	GK563, a selective Ca 2+-independent phospholipase A2 (GVIA iPLA2) inhibitor, exhibits a potent IC50 value of 1 nM and demonstrates 22,000-fold greater activity against GVIA iPLA2 compared to GIVA cPLA2. Its efficacy in ...
T82526	Drotrecogin alfa (activated)
	Drotrecogin alfa (activated) (DrotAA), a recombinant human activated protein C (APC), mitigates smoke-induced elevations in pulmonary microvascular permeability and proinflammatory cytokine IL-1β levels in rats. It also ...
T78822	JT002		NOD-like Receptor (NLR)
	JT002 is an orally active NLRP3 inflammasome inhibitor that decreases the production of NLRP3-dependent proinflammatory cytokines (such as IL-1β, IL-1α, IL-18) and pyroptosis, as well as inhibits the formation of the NLR...		NOD-like Receptor (NLR)
T79304	Semapimod	CPSI-2364,CNI-1493 free base
	Semapimod is an inhibitor of proinflammatory cytokine production, capable of suppressing TNF-α, IL-1β, and IL-6. It hinders TLR4 signaling with an IC50 of approximately 0.3 μM, impedes p38 MAPK, and reduces nitric oxide ...
T69288	CEP-7055
	CEP-18770 is an orally bioavailable synthetic P2 threonine boronic acid inhibitor of the chymotrypsin-like activity of the proteasome, with potential antineoplastic activity. Proteasome inhibitor CEP 18770 represses the ...
T75090	STING agonist-22
	STING Agonist-22 (CF501) is a potent non-nucleotide STING agonist that functions as an adjuvant by activating STING to induce the type I interferon (IFN-I) response and the production of proinflammatory cytokines. It enh...
T78018	Plasminogen
	Plasminogen is a zymogen secreted as a precursor protein that, when cleaved by urokinase plasminogen activator (uPA) or tissue plasminogen activator (tPA), is converted into plasmin. Plasmin is a protease with broad spec...
T68321	AS1940477
	AS1940477 is p38 MAPK inhibitor. AS1940477 inhibited the enzymatic activity of recombinant p38α and β isoforms but showed no effect against other 100 protein kinases including p38γ and δ isoforms. In human peripheral blo...
T75812	MMK1 TFA
	MMK1 TFA is a potent, selective agonist for the human formyl peptide receptor like-1 (FPRL-1/FPR2), exhibiting EC50 values of <2 nM for FPRL-1 and >10,000 nM for FPR1. This compound acts as a powerful chemotactic and cal...
T23028	MRT67307 HCl (1190378-57-4 free base)	MRT67307 HCl	Others
	MRT67307 is an inhibitor for TBK1, IKKε , MARK1-4 and NUAK1 with IC50 value of 19, 160, 27-52 and 230nM , respectively [1]. It is an inhibitor for ULK1and ULK2 with IC50 value of 45 and 38nM, respectively [2]. Also, it i...		Others
T36486	Benpyrine
	Benpyrine is a highly specific and orally active TNF-α inhibitor with a KD value of 82.1 μM. Benpyrine tightly binds to TNF-α and blocks its interaction with TNFR1, with an IC50 value of 0.109 μM. Benpyrine has the poten...
T35451	β-Defensin-2 (human) (trifluoroacetate salt)
	β-Defensin-2 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.1It inhibits the growth of periodontopathogenic and cari...
T36629	Givinostat
	Givinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat (ITF2357) suppresses total LPS-induced IL-1β production robustly compared with the reduction by ITF30...
T36996	MSA-2 dimer
	MSA-2 dimer, a selective and orally active non-nucleotide STING agonist with a dissociation constant (Kd) of 145 μM, demonstrates prolonged antitumor and immunogenic activity. It non-covalently binds to STING as a dimer,...
T37861	Talabostat
	Talabostat (PT100, Val-boroPro) is a potent, nonselective and orally available dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 0.18 nM. Talabostat is a nonselective DPP-IV inhibitor, inhibiting DPP8/9, FAP, DPP2 ...
T35881	Resolvin E2
	Resolvin E2 (RvE2) is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids.1It is produced from eicosapentaenoic acidviaan 18-HEPE intermediate, which is formed by aspirin-acetylated COX-2-...

Compounds

RVX-297

T28628

Synonym: RVX297

Target: Epigenetic Reader Domain

Valsartan

T6716

Synonym: Diovan,Tareg,CGP 48933

Hydrocortisone hemisuccinate

T4602

Synonym: Hydrocortisone 21-he,hydrocortisone 21-hemisuccinate*free acid,Hydrocortisone 21-hemisuccinate

Target: Glucocorticoid Receptor, Others, Interleukin

Target: Dehydrogenase, PDK

GSK2983559 free acid

T11492

Synonym:

Target: Others, RIP kinase

Synonym: SYR 322,Alogliptin(SYR-322)benzoate

Target: Ferroptosis, Proteasome, DPP-4

Beclometasone dipropionate

T1127

Synonym: Beclovent,Beclomethasone dipropionate,Beconase,Vancenase

Target: Glucocorticoid Receptor

Syk Inhibitor II hydrochloride

Synonym: VX-740,HMR 3480

Endotrophin (Mus musculus)

(R)-DOI hydrochloride

Synonym: DX9065,DX 9065,DX9065A,DX 9065A,DX-9065A,DX-9065

Anti-inflammatory agent 7

Synonym: Ppack dihydrochloride,Fprmecl, dihydrochloride

Target:

Ppack trifluoroacetate

T25977

Synonym: Ppack trifluoroacetate salt

Target: NOD-like Receptor (NLR)

Drotrecogin alfa (activated)

Target: NOD-like Receptor (NLR)

Semapimod

T79304

Synonym: CPSI-2364,CNI-1493 free base

MRT67307 HCl (1190378-57-4 free base)

T23028

Synonym: MRT67307 HCl

β-Defensin-2 (human) (trifluoroacetate salt)

カタログ番号	製品名	別名	ターゲット
TN6730	Epoxyazadiradione		NF-κB
	Epoxyazadiradione is an extract from Neem (Azadirachta indica) plant and may induce mitochondrial apoptosis and inhibition of NF-kB in human cervical cancer cells.		NF-κB
TQ0218	Deoxyandrographolide	14-deoxyandrographolide	IL Receptor , TNF
			IL Receptor , TNF
T7926	Carmoisine	Azo Rubine,Chromotrope FB	Others
	Carmoisine (Azo Rubine) is a food dye Azorubine and is used for the purposes where food is heat-treated after fermentation.		Others
TQ0054	Purpureaside C		Others
	Purpureaside C has significant proinflammatory, immunomodulating and antimicrobial effects.		Others
T10689	Cauloside D		Others
	Cauloside D, a triterpene glycoside isolated from Caulophyllum robustum Max, inhibits the expression of iNOS and proinflammatory cytokines with anti-inflammatory effects.		Others
T5660	Menthone		IL Receptor , TNF , NF-κB , Parasite
	Menthone has anti-inflammary activity,, it can suppress the lipopolysaccharide (LPS)-induced proinflammatory cytokines, interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha),as well as nuclear factor k...		IL Receptor , TNF , NF-κB , Parasite
T3887	Rosarin		Others
	Rosarin has anti-inflammatory and neuroprotective effects. Rosarin supresses the expression of the proinflammatory factors iNOS, IL-1 β, and TNF- α in the kidney and prefrontal cortex of brain in mice .		Others
TJS0315	4-Methyldaphnetin	7,8-Dihydroxy-4-methylcoumarin,DHMC	Apoptosis , Lipoxygenase
	4-Methyldaphnetin (DHMC) is a potent inhibitor (low micromolar) of lipid peroxidation and scavengers of superoxide anion radicals and of aqueous alkylperoxyl radicals, but may be pro-oxidant (enhancing generation of hydr...		Apoptosis , Lipoxygenase
T2S2173	(E)-Naringenin chalcone	Isosalipurpol,Chalconaringenin,trans-2'4'6'4-tetrahydroxychalcone	Others
	Naringenin chalcone (Isosalipurpol) has antiallergic activity Naringenin chalcone suppresses asthmatic symptoms by inhibiting Th2 cytokine production from CD4 T cells. Naringenin chalcone is a potent tomato flavonoid tha...		Others
TN1448	(-)-Bornyl acetate	L-(-)-Bornyl acetate,Bornyl acetate	p38 MAPK , NF-κB , JNK , Antifungal
	(-)-Bornyl acetate (L-(-)-Bornyl acetate) is a less active enantiomer of (+)-Bornyl acetate. (-)-Bornyl acetate isolates from hyssop oil and possesses antifungal activity. (-)-Bornyl acetate shows highly active whitening...		p38 MAPK , NF-κB , JNK , Antifungal
T3795	Corilagin		Apoptosis , TLR , Reverse Transcriptase , Antibacterial , Autophagy
	Corilagin has anti-inflammatory activity. Corilagin has a significant antitumour potential and lower toxicity in normal cells in vitro.Corilagin can enhance the cytotoxicity of both cisplatin and doxorubicin on the Hep3B...
T6S1487	Ginsenoside Rg5		NF-κB , COX , IGF-1R
	1. Ginsenoside Rg5 could be a beneficial agent for the treatment of Alzheimer's disease. 2. Ginsenoside Rg5 suppresses LPS-induced nitric oxide (NO) production and proinflammatory TNF-α secretion. 3. Ginsenoside Rg5 can ...		NF-κB , COX , IGF-1R
T3753	Sinapinic Acid	Sinapic acid,Synapoic acid	Apoptosis , RAAS , Reactive Oxygen Species , HDAC
	Sinapinic Acid (Synapoic acid) protects the rat liver from CCl4-induced inflammation, most likely by acting as a free radical scavenger and modulator of NF-κB p65 activation and proinflammatory cytokine expression. Sinap...		Apoptosis , RAAS , Reactive Oxygen Species , HDAC
T4S2326	Cornuside	7-Galloylsecologanol,7-O-Galloylsecologanol,Comuside	ERK , p38 MAPK , NF-κB , JNK
	1. Cornuside (Comuside) has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human endothelial cells. 3. Cornuside can treat myocardi...		ERK , p38 MAPK , NF-κB , JNK
T4S0797	Berberine	Berberin,Umbellatine	Reactive Oxygen Species , Topoisomerase , Endogenous Metabolite , Antibacterial , Antibiotic , Autophagy
	1. Berberine (Umbellatine) is a potent oral hypoglycemic agent with beneficial effects on lipid metabolism. 2. Berberine may as a broad-spectrum anti-microbial medicine, a complementary therapeutic agent for HIV/AIDS. 3....
TN6442	Esculentoside C
	Esculentoside C exerts proinflammatory effects synergistically, it can induce inflammatory stimulation.
TN4093	Galeopsin		TNF
	Galeopsin shows potential anti-inflammatory activity by inhibiting proinflammatory cytokine TNF-α, it has anti-proliferative effect on several cancer cell lines.		TNF
TN1504	Citreorosein		cAMP , NF-κB , PI3K
	Citreorosein is a cAMP phosphodiesterase inhibitor, it has anti-inflammatory effect, inhibits proinflammatory cytokines production through the inhibition of both MAPKs and AKT-mediated IκB kinase (IKK) phosphorylation an...		cAMP , NF-κB , PI3K
T14877	Cauloside C		Others
	Cauloside C, a triterpene glycoside isolated from Caulophyllum robustum Max, exerts anti-inflammatory effects through the inhibition of expression of iNOS and proinflammatory cytokines.		Others
T78497	λ-Carrageenan
	λ-Carrageenan, a seaweed-derived polysaccharide, is commonly utilized as a proinflammatory agent in basic research and has also been identified as a potent antitumor agent [1].
T79970	Taxamairin B
	Taxamairin B is a potent anti-inflammatory compound that inhibits the expression of proinflammatory cytokines (TNF-α, IL-1β, and IL-6) and reduces the production of NO and ROS in LPS-induced RAW264.7 cells. Furthermore, ...
TN6524	Irilone
	Irilone has immunomodulatory, and α-amylase inhibitory activities, it exhibits the selective inhibition toward CYP3 A4 rather than other major human CYPs. Irilone exhibited prominent antioxidant activities with the IC50 ...

天然物製品

Synonym: 14-deoxyandrographolide

Target: IL Receptor, TNF

Carmoisine

T7926

Synonym: Azo Rubine,Chromotrope FB

Target: IL Receptor, TNF, NF-κB, Parasite

Synonym: 7,8-Dihydroxy-4-methylcoumarin,DHMC

Target: Apoptosis, Lipoxygenase

(E)-Naringenin chalcone

T2S2173

Synonym: Isosalipurpol,Chalconaringenin,trans-2'4'6'4-tetrahydroxychalcone

Target: Others

(-)-Bornyl acetate

TN1448

Synonym: L-(-)-Bornyl acetate,Bornyl acetate

Target: p38 MAPK, NF-κB, JNK, Antifungal

Corilagin

T3795

Synonym:

Target: Apoptosis, TLR, Reverse Transcriptase, Antibacterial, Autophagy

Ginsenoside Rg5

T6S1487

Synonym:

Target: NF-κB, COX, IGF-1R

Sinapinic Acid

T3753

Synonym: Sinapic acid,Synapoic acid

Target: Apoptosis, RAAS, Reactive Oxygen Species, HDAC

Cornuside

T4S2326

Synonym: 7-Galloylsecologanol,7-O-Galloylsecologanol,Comuside

Target: ERK, p38 MAPK, NF-κB, JNK

Berberine

T4S0797

Synonym: Berberin,Umbellatine

Target: Reactive Oxygen Species, Topoisomerase, Endogenous Metabolite, Antibacterial, Antibiotic, Autophagy

Target: cAMP, NF-κB, PI3K

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPJ-00327	M-CSF/CSF1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Macrophage Colony-Stimulating Factors (m-csf) are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and th...
TMPJ-01210	IL-33 Protein, Mouse, Recombinant	Mouse	E. coli
	Mouse Interleukin 33 (IL-33) is a 30 kDa proinflammatory cytokine which may also regulates gene transcription in producer cells. IL-33 is constitutively expressed in smooth muscle and airway epithelia. IL-33 was identifi...
TMPY-02869	MMP-12 Protein, Human, Recombinant (catalytic domain)	Human	E. coli
	Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, ...
TMPH-02856	SAAL1 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Plays a role in promoting the proliferation of synovial fibroblasts in response to proinflammatory stimuli.
TMPH-03545	Enterotoxin type E Protein, S. aureus, Recombinant (His & SUMO)	Staphylococcus aureus	E. coli
	Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules. In turn, this ternary complex a...
TMPY-06479	Cathepsin H Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Proinflammatory cytokines decreased the expression of CTSH in human islets and primary rat beta-cells, and overexpression of CTSH protected insulin-secreting cells against cytokine-induced apoptosis. Cathepsin H Protein,...
TMPY-04081	Cathepsin H Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Proinflammatory cytokines decreased the expression of CTSH in human islets and primary rat beta-cells, and overexpression of CTSH protected insulin-secreting cells against cytokine-induced apoptosis. Cathepsin H Protein,...
TMPH-03539	Enterotoxin type B Protein, S. aureus, Recombinant (His)	Staphylococcus aureus	P. pastoris (Yeast)
	Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules. In turn, this ternary complex a...
TMPK-00867	EMAP-II/AIMP1 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	The potent antiangiogenic and proinflammatory protein Endothelial Monocyte Activating Polypeptide II (EMAP II) has been described as a mediator of pulmonary vascular and alveolar formation and its expression is inversely...
TMPK-01169	IL-23 P19/IL23A Protein, Mouse, Recombinant (His & Avi), Biotinylated	Mouse	HEK293 Cells
	The heterodimeric cytokine interleukin-23 (IL-23 or IL23A/IL12B) is produced by dendritic cells and macrophages and promotes the proinflammatory and regenerative activities of T helper 17 (Th17) and innate lymphoid cells...
TMPH-03543	Enterotoxin type C-3 Protein, S. aureus, Recombinant (His & SUMO)	Staphylococcus aureus	E. coli
	Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules. In turn, this ternary complex a...
TMPY-01033	IL-32 Protein, Human, Recombinant (isoform alpha, His)	Human	HEK293 Cells
	IL-32 is a recently discovered cytokine that induces various proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6) and chemokines in both human and mouse cells through the NF-kappaB and p38 MAPK inflammatory signal pathw...
TMPH-03542	Enterotoxin type C-2 Protein, S. aureus, Recombinant	Staphylococcus aureus	E. coli
	Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules. In turn, this ternary complex a...
TMPH-03540	Enterotoxin type B Protein, S. aureus, Recombinant (GST)	Staphylococcus aureus	E. coli
	Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules. In turn, this ternary complex a...
TMPH-03541	Enterotoxin type C-2 Protein, S. aureus, Recombinant (His & SUMO)	Staphylococcus aureus	E. coli
	Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules. In turn, this ternary complex a...
TMPK-00872	ICAM-1/CD54 Protein, Canine, Recombinant (His)	Canine	HEK293 Cells
	Intercellular adhesion molecule-1 (ICAM-1; CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. ICAM-...
TMPK-00650	HLA-A*02:01 & B2M & MART-1 (ELAGIGILTV) Monomer Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	Interleukin 10 (IL10) is a key anti-inflammatory cytokine that can inhibit proinflammatory responses of both innate and adaptive immune cells. An association between IL10 and intestinal mucosal homeostasis became clear w...
TMPK-00298	ANGPTL2 Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	Angiopoietin-like 2 (ANGPTL2) is a proinflammatory protein belonging to the angiopoietin-like family. ANGPTL2 is secreted and detected in the systemic circulation. Different observational clinical studies reported that c...
TMPK-00057	IL-10 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	Interleukin 10 (IL10) is a key anti-inflammatory cytokine that can inhibit proinflammatory responses of both innate and adaptive immune cells. An association between IL10 and intestinal mucosal homeostasis became clear w...
TMPH-01559	IL-26 Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expre...
TMPK-00299	ANGPTL2 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	Angiopoietin-like 2 (ANGPTL2) is a proinflammatory protein belonging to the angiopoietin-like family. ANGPTL2 is secreted and detected in the systemic circulation. Different observational clinical studies reported that c...
TMPH-01560	IL-26 Protein, Human, Recombinant (His & Trx)	Human	E. coli
	May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expre...
TMPK-00056	IL-10 Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	Interleukin 10 (IL10) is a key anti-inflammatory cytokine that can inhibit proinflammatory responses of both innate and adaptive immune cells. An association between IL10 and intestinal mucosal homeostasis became clear w...
TMPH-00779	IL-23 P19/IL23A Protein, Guinea Pig, Recombinant (His & Myc)	Guinea pig	E. coli
	Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 b...
TMPK-00497	ICAM-1/CD54 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	Intercellular adhesion molecule-1 (ICAM-1; CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. ICAM-...
TMPJ-00324	ICAM-1/CD54 Protein, Rhesus macaque, Recombinant (hFc)	Rhesus	HEK293 Cells
	Intercellular adhesion molecule 1 (ICAM1) is known as CD54. ICAM-1 is constitutively present on endothelial cells, but its expression is increased by proinflammatory cytokines. The endothelial expression of ICAM-1 is inc...
TMPH-03544	Enterotoxin type D Protein, S. aureus, Recombinant (His & SUMO)	Staphylococcus aureus	E. coli
	Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules. In turn, this ternary complex a...
TMPH-01702	SMAD6 Protein, Human, Recombinant (E. coli, His & Myc)	Human	E. coli
	Transforming growth factor-beta superfamily receptors signaling occurs through the Smad family of intracellular mediators. SMAD6 is an inhibitory Smad (i-Smad) that negatively regulates signaling downstream of type I tra...
TMPJ-01325	TOLLIP Protein, Human, Recombinant (His)	Human	E. coli
	Toll-Interacting Protein (TOLLIP) is a member of the tollip family. TOLLIP localizes to the cytoplasm. It contains one C2 domain and one CUE domain. TOLLIP is an inhibitory adaptor protein for Toll-like receptors (TLR). ...
TMPH-02211	TLR7 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine...
TMPJ-00060	IL-25/IL17E Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Interleukin 25 (IL-25) belongs to the Interleukin 17 (IL-17) family of proteins, which is comprised of six members (IL-17, IL-17B through IL-17F). These proteins are secreted and are structurally related by sharing a con...
TMPH-02697	GNA12 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG). G...
TMPK-00084	IL-17C Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	Interleukin‑17C (IL‑17C) is a 15‑20 kDa glycosylated cytokine that plays an important role in mucosal immunity and chronic inflammation. The six IL‑17 cytokines (IL‑17A‑F) are encoded by separate genes but adopt a conser...
TMPY-00176	FNDC4 Protein, Human, Recombinant (mFc)	Human	HEK293 Cells
	FNDC4 acts as an anti-inflammatory factor on macrophages and improves mouse model of induced colitis. FNDC4 could suppress osteoclast formation via NF-kappaB pathway and downregulation of CXCL10. Analysis of binding of F...
TMPH-02212	TLR8 Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are initially proc...
TMPJ-00070	IL-18 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Interleukin-18 is a secreted protein and it belongs to the IL-1 family. IL-18 is a proinflammatory cytokine and produced by macrophages and other cells. This cytokine can induce the IFN-gamma production of T cells. The c...
TMPJ-01218	M-CSF/CSF1 Protein, Rat, Recombinant	Rat	HEK293 Cells
	Rat Macrophage colony-stimulating factor 1(MCSF,CSF1) is a single-pass type I membrane cytokine. It is a hematopoietic growth factor that plays an essential role in the regulation of survival, proliferation and different...
TMPJ-01237	IL-17D Protein, Human, Recombinant	Human	E. coli
	The Interleukin-17 family proteins, comprising six members (IL-17, IL-17B through IL-17F),are secreted, structurally related proteins that share a conserved cysteine-knot fold near the C-terminus, but have considerable s...
TMPY-04425	PRAK/MAPKAPK5 Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	MAPKAPK5 contains 1 protein kinase domain and belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family. MAPKAPK5 has significant sequence homology to mitogen-activated protein kinase (MAPK)-activated...
TMPJ-00993	CCL5 Protein, Rat, Recombinant (E. coli, His)	Rat	E. coli
	C-C motif chemokine 5(CCL5) is a β-chemokine that plays a primary role in the inflammatory immune response by means of its ability to attract and activate leukocytes. CCL5 is secreted by many cell types at inflammatory s...
TMPY-01910	TIE1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 also known as Tie1 is an angiopoietin receptor and is an orphan receptor tyrosine kinase that is expressed almost exclusively in endothelial cells and that ...
TMPY-04378	MAPKAPK3 Protein, Human, Recombinant (GST)	Human	Baculovirus Insect Cells
	The MAPKAP kinases are a group of MAP kinase substrates that are themselves kinases. In response to activation, the MAP kinases phosphorylate downstream components on a consensus Pro-X-Ser/Thr-Pro motif. Several kinases ...
TMPY-05353	CCL26 Protein, Human, Recombinant	Human	Baculovirus Insect Cells
	The eotaxin subfamily of CC chemokines consists of eotaxin-1/CCL11, eotaxin-2/CCL24 and eotaxin-3/CCL26. All eotaxins induce the trafficking of eosinophils to the sites of inflammation via CC chemokine receptor 3 (CCR3),...
TMPH-02521	PYCARD Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner. Involved in activation of the mit...
TMPY-04260	P38 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	MAPK14 contains 1 protein kinase domain and belongs to the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as prol...
TMPY-01816	Pentraxin 3 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Pentraxin-related protein PTX3, also known as Tumor necrosis factor alpha-induced protein 5, Tumor necrosis factor-inducible gene 14 protein, TSG-14, PTX3 and TNFAIP5, is a secreted protein that contains one pentaxin dom...
TMPH-02832	Serpin A5 Protein, Mouse, Recombinant (His)	Mouse	Baculovirus Insect Cells
	Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extr...
TMPH-02841	Prohibitin Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regul...
TMPY-01187	Rac1 Protein, Human, Recombinant (GST)	Human	Baculovirus Insect Cells
	RAC1 is a GTPase that belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal re...
TMPH-01503	Humanin Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Plays a role as a neuroprotective factor. Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease. Mediates its neuroprotective e...
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M-CSF/CSF1 Protein, Human, Recombinant (His)

TMPJ-00327

Species: Human

Expression System: HEK293 Cells

IL-33 Protein, Mouse, Recombinant

TMPJ-01210

Species: Mouse

Expression System: E. coli

MMP-12 Protein, Human, Recombinant (catalytic domain)

TMPY-02869

Species: Human

Expression System: E. coli

SAAL1 Protein, Mouse, Recombinant (His & Myc)

TMPH-02856

Species: Mouse

Expression System: E. coli

Enterotoxin type E Protein, S. aureus, Recombinant (His & SUMO)

TMPH-03545

Species: Staphylococcus aureus

Expression System: E. coli

Cathepsin H Protein, Human, Recombinant (His)

TMPY-06479

Species: Human

Expression System: HEK293 Cells

Cathepsin H Protein, Mouse, Recombinant (His)

TMPY-04081

Species: Mouse

Expression System: HEK293 Cells

Enterotoxin type B Protein, S. aureus, Recombinant (His)

TMPH-03539

Species: Staphylococcus aureus

Expression System: P. pastoris (Yeast)

EMAP-II/AIMP1 Protein, Mouse, Recombinant (His)

TMPK-00867

Species: Mouse

Expression System: E. coli

IL-23 P19/IL23A Protein, Mouse, Recombinant (His & Avi), Biotinylated

TMPK-01169

Species: Mouse

Expression System: HEK293 Cells

Enterotoxin type C-3 Protein, S. aureus, Recombinant (His & SUMO)

TMPH-03543

Species: Staphylococcus aureus

Expression System: E. coli

IL-32 Protein, Human, Recombinant (isoform alpha, His)

TMPY-01033

Species: Human

Expression System: HEK293 Cells

Enterotoxin type C-2 Protein, S. aureus, Recombinant

TMPH-03542

Species: Staphylococcus aureus

Expression System: E. coli

Enterotoxin type B Protein, S. aureus, Recombinant (GST)

TMPH-03540

Species: Staphylococcus aureus

Expression System: E. coli

Enterotoxin type C-2 Protein, S. aureus, Recombinant (His & SUMO)

TMPH-03541

Species: Staphylococcus aureus

Expression System: E. coli

ICAM-1/CD54 Protein, Canine, Recombinant (His)

TMPK-00872

Species: Canine

Expression System: HEK293 Cells

HLA-A*02:01 & B2M & MART-1 (ELAGIGILTV) Monomer Protein, Cynomolgus, Recombinant (His)

TMPK-00650

Species: Cynomolgus

Expression System: HEK293 Cells

ANGPTL2 Protein, Human, Recombinant (His & Avi)

TMPK-00298

Species: Human

Expression System: HEK293 Cells

IL-10 Protein, Human, Recombinant (His & Avi), Biotinylated

TMPK-00057

Species: Human

Expression System: HEK293 Cells

IL-26 Protein, Human, Recombinant (His)

TMPH-01559

Species: Human

Expression System: P. pastoris (Yeast)

ANGPTL2 Protein, Human, Recombinant (His & Avi), Biotinylated

TMPK-00299

Species: Human

Expression System: HEK293 Cells

IL-26 Protein, Human, Recombinant (His & Trx)

TMPH-01560

Species: Human

Expression System: E. coli

IL-10 Protein, Human, Recombinant (His & Avi)

TMPK-00056

Species: Human

Expression System: HEK293 Cells

IL-23 P19/IL23A Protein, Guinea Pig, Recombinant (His & Myc)

TMPH-00779

Species: Guinea pig

Expression System: E. coli

ICAM-1/CD54 Protein, Cynomolgus, Recombinant (His)

TMPK-00497

Species: Cynomolgus

Expression System: HEK293 Cells

ICAM-1/CD54 Protein, Rhesus macaque, Recombinant (hFc)

TMPJ-00324

Species: Rhesus

Expression System: HEK293 Cells

Enterotoxin type D Protein, S. aureus, Recombinant (His & SUMO)

TMPH-03544

Species: Staphylococcus aureus

Expression System: E. coli

SMAD6 Protein, Human, Recombinant (E. coli, His & Myc)

TMPH-01702

Species: Human

Expression System: E. coli

TOLLIP Protein, Human, Recombinant (His)

TMPJ-01325

Species: Human

Expression System: E. coli

TLR7 Protein, Human, Recombinant (His & Myc)

TMPH-02211

Species: Human

Expression System: E. coli

IL-25/IL17E Protein, Human, Recombinant (His)

TMPJ-00060

Species: Human

Expression System: HEK293 Cells

GNA12 Protein, Mouse, Recombinant (His & Myc)

TMPH-02697

Species: Mouse

Expression System: E. coli

IL-17C Protein, Human, Recombinant (His & Avi)

TMPK-00084

Species: Human

Expression System: HEK293 Cells

FNDC4 Protein, Human, Recombinant (mFc)

TMPY-00176

Species: Human

Expression System: HEK293 Cells

TLR8 Protein, Human, Recombinant (His)

TMPH-02212

Species: Human

Expression System: P. pastoris (Yeast)

IL-18 Protein, Human, Recombinant (His)

TMPJ-00070

Species: Human

Expression System: HEK293 Cells

M-CSF/CSF1 Protein, Rat, Recombinant

TMPJ-01218

Species: Rat

Expression System: HEK293 Cells

IL-17D Protein, Human, Recombinant

TMPJ-01237

Species: Human

Expression System: E. coli

PRAK/MAPKAPK5 Protein, Human, Recombinant (His & GST)

TMPY-04425

Species: Human

Expression System: Baculovirus Insect Cells

CCL5 Protein, Rat, Recombinant (E. coli, His)

TMPJ-00993

Species: Rat

Expression System: E. coli

TIE1 Protein, Human, Recombinant (His)

TMPY-01910

Species: Human

Expression System: HEK293 Cells

MAPKAPK3 Protein, Human, Recombinant (GST)

TMPY-04378

Species: Human

Expression System: Baculovirus Insect Cells

CCL26 Protein, Human, Recombinant

TMPY-05353

Species: Human

Expression System: Baculovirus Insect Cells

PYCARD Protein, Mouse, Recombinant (His & Myc)

TMPH-02521

Species: Mouse

Expression System: E. coli

p38 Protein, Human, Recombinant (His)

TMPY-04260

Species: Human

Expression System: Baculovirus Insect Cells

Pentraxin 3 Protein, Human, Recombinant (His)

TMPY-01816

Species: Human

Expression System: HEK293 Cells

Serpin A5 Protein, Mouse, Recombinant (His)

TMPH-02832

Species: Mouse

Expression System: Baculovirus Insect Cells

Prohibitin Protein, Mouse, Recombinant (His)

TMPH-02841

Species: Mouse

Expression System: E. coli

Rac1 Protein, Human, Recombinant (GST)

TMPY-01187

Species: Human

Expression System: Baculovirus Insect Cells

Humanin Protein, Human, Recombinant (hFc)

TMPH-01503

Species: Human

Expression System: HEK293 Cells

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カタログ番号	製品名
L6710	Anti-Inflammatory Traditional Chinese Medicine Compound Library		1246 compounds
	A collection of 1246 TCM monomers with anti-inflammatory activity or targeting molecular therapeutic targets in inflammation, a powerful tool for drug discovery and mechanism study；

ライブラリー

Anti-Inflammatory Traditional Chinese Medicine Compound Library

L6710

Compounds: 1246