|
T9911 |
Tocilizumab
|
|
Interleukin
|
|
Tocilizumab (anti-IL-6R) is a humanized monoclonal antibody that binds to the interleukin-6 receptor |
|
T1421 |
Aceclofenac
|
Preservex,Airtal |
COX
|
|
Aceclofenac (Preservex) is a non-steroidal anti-inflammatory drug (NSAID) with marked anti-inflammatory and analgesic properties. |
|
T11699 |
J-113863
|
|
CCR
|
|
J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM). J-113863 is inactive against CCR2, CCR4 and CCR5, as well as the LTB4 or TNF-α receptor... |
|
T0291 |
Flurbiprofen
|
dl-Flurbiprofen |
Apoptosis
,
COX
,
MRP
|
|
Flurbiprofen (dl-Flurbiprofen) is an anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption in periodontal disease by inhibiting CARBONIC ANHYDRASE. |
|
T4561 |
Tiaprofenic acid
|
Tiaprofensaeure,Acido tiaprofenico,Surgam |
Others
,
COX
|
|
Tiaprofenic acid (Acido tiaprofenico) is a non-steroidal anti-inflammatory drug used to treat pain, especially arthritic pain. |
|
T60012 |
HS-243
|
|
IRAK
,
MAPK
,
CDK
|
|
HS-243 is an inhibitor of IRAK-4 and IRAK-1 with IC50s of 20 and 24 nM. HS-243 shows anti-inflammatory and anticancer activity. |
|
T20168 |
Aurothiomalate sodium
|
Myocrisin,Myocrisine,Miochrysin,Sodium aurothiomalate,Myochrysine,gold sodium thiomalate |
Others
,
PKC
|
|
Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Aurothiomalate sodium (Miochrysin) is a potent and selective inhibitor of oncogenic PKC-ι signaling. Aurothiomalate ... |
|
T15253 |
CCX354
|
CCR1 antagonist 1,CCX-354,CCX 354 |
CCR
|
|
CCX354 (CCR1 antagonist 1) is a potent small molecule CCR1 antagonist with anti-inflammatory activity for the treatment of rheumatoid arthritis. |
|
T19641 |
Epirizole
|
DA 398,Mepirizole,DA398,Mebron,Methopyrimazole,Dalex,DA-398 |
Others
|
|
Epirizole (Mebron) shows antipyretic, analgesic, and anti-inflammatory activity and can be used in studies about chronic rheumatoid arthritis. |
|
T76937 |
Burfiralimab
|
hzVSF-v13 |
HBV
|
|
Burfiralimab (hzVSF-v13) is a monoclonal immunoglobulin (IgG4) directed against waveform proteins that
has anti-HBV effects and can be used to study rheumatoid arthritis, |
|
T0693 |
Niflumic acid
|
Nifluril,Forenol,Landruma |
Others
,
Phospholipase
,
Chloride channel
,
COX
,
Monocarboxylate transporter
,
UGT
|
|
Niflumic acid (Nifluril) is a Ca2+-activated Cl- channel blocker and an analgesic and anti-inflammatory agent used in the therapy of rheumatoid arthritis. |
|
T27312 |
Fentiazac
|
Donorest,Flogene,BR-700 |
Others
|
|
Fentiazac（BR-700） is an orally active nonsteroidal alkanoic acid derivative with significant analgesic, anti-inflammatory, and antipyretic activity.Fentiazac is used in the study of inflammatory diseases such as rheumato... |
|
T76741 |
Eldelumab
|
BMS-936557,MDX-1100 |
CXCR
|
|
Eldelumab (BMS-936557) is a humanized anti-IP-10 IgG type 1 monoclonal antibody with inhibitory activity against CXCL10.Eldelumab has anti-inflammatory activity and selectively binds to CXCL10 and can be used in the stud... |
|
T76711 |
Golimumab
|
MK-8259,SCH 900259,CNTO-148 |
TNF
|
|
Golimumab (CNTO-148) is a potent humanized anti-TNFα IgG1κ monoclonal antibody.Golimumab has anti-inflammatory and anticancer activity, inhibits the production of IL-6 and IL-1β, and induces apoptosis.Golimumab can be us... |
|
T20763 |
Betamethasone disodium phosphate
|
Vista-Methasone,NSC90616,Betamethasone 21-phosphate disodium salt,NSC-90616 |
Others
|
|
Betamethasone disodium phosphate (Betamethasone 21-phosphate disodium salt) is a corticosteroid with anti-inflammatory activity that promotes the polarization of M1 to M2 macrophages by decreasing the secretion of pro-in... |
|
T1432 |
Phenylbutazone
|
Butazolidine |
COX
|
|
Phenylbutazone (Butazolidine) is a butyl-diphenyl-pyrazolidinedione that has anti-inflammatory, antipyretic, and analgesic activities. It has been used in ankylosing spondylitis, rheumatoid arthritis, and reactive arthri... |
|
T0855 |
(R)-Naproxen
|
|
COX
|
|
(R)-Naproxen, an anti-inflammatory agent, has antipyretic and analgesic properties. Both the acid and its sodium salt are used in the therapy of acute gout or dysmenorrhea, musculoskeletal disorders, rheumatoid arthritis... |
|
T0219 |
Valdecoxib
|
SC 65872 |
COX
|
|
Valdecoxib (SC 65872) is a prescription drug used in the treatment of osteoarthritis, rheumatoid arthritis, and painful menstruation and menstrual symptoms. It is classified as a nonsteroidal anti-inflammatory drug, or N... |
|
T77093 |
Theralizumab
|
TGN1412,TAB-08,TABO8 |
Others
|
|
Theralizumab (TGN1412) is an anti-CD28-targeting monoclonal antibody that directly stimulates T cells. Theralizumab has antitumor activity and is used for the treatment of B-cell chronic lymphocytic leukemia and rheumato... |
|
T22346 |
Indomethacin sodium hydrate
|
Indometacin sodium hydrate |
COX
|
|
Indomethacin sodium hydrate (Indometacin sodium hydrate) is an orally active, competitive and reversible COX1/2 inhibitor with potential anti-inflammatory activity in induced migraines, induced gastrointestinal injuries,... |
|
T2513 |
VX-702
|
|
p38 MAPK
,
Autophagy
|
|
VX-702 is a highly specific p38α MAPK inhibitor, 14-fold higher selectivity for the p38α than p38β. VX-702 is a small molecule investigational oral anti-cytokine therapy for treatment of inflammatory diseases, specifical... |
|
T76781 |
Itolizumab
|
EQ-001 |
Others
|
|
Itolizumab (Anti-Human CD6 Recombinant Antibody) is a recombinant anti-CD6 monoclonal antibody that humanizes the extracellular SRCR distal domain 1 of CD6. Itolizumab slows T cell proliferation and inhibits the producti... |
|
T72505 |
CTP Synthetase-IN-1
|
|
Others
|
|
CTP Synthetase-IN-1 is an orally active and potent cytidine 5'-triphosphate synthetase (CTPS) inhibitor with potential antitumour activity, shows anti-inflammatory activity in animal models of inflammation, inhibits huma... |
|
T63119 |
NF-κB/MAPK-IN-1
|
|
NF-κB
,
MAPK
|
|
NF-κB/MAPK-IN-1 is a potent dual inhibitor of the NF-κB and MAPK pathways with potential anti-inflammatory activity, inhibition of NO production, and inhibition of LPS-induced activation of iNOS, COX-2, ERΚ and P38. NF-κ... |
|
T69458 |
Pirprofen
|
|
|
|
Pirprofen is an anti-inflammatory agent used in therapy of rheumatoid arthritis and a prostaglandin synthetase inhibitor. |
|
T25036 |
Alclofenac sodium
|
|
|
|
Alclofenac sodium is an anti-inflammatory utilized in the treatment of rheumatoid arthritis. |
|
T25035 |
Alclofenac lysinate
|
|
|
|
Alclofenac is an anti-inflammatory agent used in the treatment of rheumatoid arthritis. It also used as an analgesic and an antipyretic. |
|
T0184L |
Fenoprofen
|
Nalgesic,Fenoprofen Calcium,Nalfon |
|
|
Fenoprofen is a non-steroidal anti-inflammatory drug used to relieve symptoms of rheumatoid arthritis, osteoarthritis, and mild to moderate pain. It can block the enzyme that produces prostaglandin (cyclooxygenase), resu... |
|
T26710 |
Azapropazone
|
DuP-141,NSC-102824,AHR-3018,AHR 3018,MI-85 |
|
|
Azapropazone is anti-inflammatory agent. Azapropazone has uricosuric properties used to treat rheumatoid arthritis and ankylosing spondylitis. Azapropazone lowered plasma uric acid but exerted only a modest and variable ... |
|
T68563 |
Piroxicam olamine
|
|
|
|
Piroxicam olamine is a cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmeno... |
|
T77116 |
Plonmarlimab
|
|
|
|
Plonmarlimab (TJ003234), an anti-GM-CSF monoclonal antibody, is utilized in researching rheumatoid arthritis and COVID-19 [1] [2]. |
|
T76898 |
Adalimumab beta
|
|
|
|
Adalimumab beta (ABP-501) is an anti-TNF-α monoclonal antibody utilized in the study of rheumatoid arthritis (RA) [1]. |
|
T77025 |
Gimsilumab
|
|
|
|
Gimsilumab (MORAb-022), a humanized anti-GM-CSF monoclonal antibody, shows promise in the research of COVID-19 and rheumatoid arthritis (RA) [1] [2]. |
|
T62473 |
Edecesertib
|
|
|
|
Edecesertib (GS-5718) is a selective, orally active IRAK-4 inhibitor that exhibits anti-inflammatory activity. edecessertib can be used to study rheumatoid arthritis (RA) and lupus erythematosus (LE). |
|
T78759 |
VEGFR2-IN-4
|
|
VEGFR
|
|
VEGFR2-IN-4 (compound 25) is a potent, selective inhibitor of the VEGFR2 kinase, exhibiting a GI50 of 0.7 nM and demonstrating anti-angiogenic effects. It is utilized in rheumatoid arthritis research [1]. |
|
T68211 |
Piroxicam betadex
|
|
|
|
Piroxicam betadex is a nonsteroidal anti-inflammatory drug. The mechanism of action of piroxicam is as a cyclooxygenase Inhibitor. It is well established in treating rheumatoid arthritis and osteoarthritis and used for ... |
|
T72252 |
RORγt inverse agonist 14
|
|
ROR
|
|
RORγt inverse agonist 14 (8e) is a potent, selective, and orally active compound with an EC50 of 2.5 nM, exhibiting anti-inflammatory activity. It is employed in researching rheumatoid arthritis and psoriasis [1]. |
|
T80744 |
Zanolimumab
|
Anti-Human CD4 Recombinant Antibody |
|
|
Zanolimumab (Anti-Human CD4 Recombinant Antibody) is a fully human monoclonal antibody that targets the CD4 molecule and effectively inhibits T-cell receptor (TCR) signal transduction. It is used in the research of rheum... |
|
T81403 |
Priliximab
|
cM-T412,CEN 000029 |
|
|
Priliximab (CEN 000029), an anti-CD4 humanized monoclonal antibody, binds to CD4 receptors on T cells, leading to a significant and sustained decrease in circulating CD4+ T cells. This property renders it useful in the s... |
|
T78012 |
CCP peptide TFA
|
|
|
|
CCP Peptide TFA, a synthetic cyclic citrullinated peptide, serves as a serological substrate for the detection of anti-CCP antibodies and is a highly specific target for autoantibodies associated with rheumatoid arthriti... |
|
T62969 |
PDE4-IN-6
|
|
|
|
PDE4-IN-6 is a safe, potent and moderately selective inhibitor of PDE4, acting on PDE4B (IC50: 0.125 μM) and PDE4D (IC50: 0.43 μM). PDE4-IN-6 is able to down-regulate TNF-α and IL-6 expression levels, exhibits anti-infla... |
|
T76935 |
Briakinumab
|
|
|
|
Briakinumab (ABT-874), a fully human anti-IL-12/23p40 monoclonal antibody, selectively targets and neutralizes IL-12 and IL-23. This compound is utilized in the research of various autoimmune disorders, including rheumat... |
|
TP1409L |
CCP peptide acetate
|
CCP peptide acetate(277748-59-1 Free base) |
Others
|
|
CCP peptide acetate is a synthetic cyclic citrullinated peptide (CCP). CCP peptide acetate can be used as the substrate for detecting anti-CCP antibodies serologically. CCP peptide acetate functions as a target for autoa... |
|
T76878 |
Vobarilizumab
|
|
|
|
Vobarilizumab (ALX-0061) is a monoclonal antibody (mAb) targeting the IL-6 receptor (IL-6R) with a dissociation constant (Kd) of 0.19 pM, indicating high affinity for its target. This compound features both an anti-IL-6R... |
|
T68297 |
Dilmapimod tosylate
|
|
|
|
Dilmapimod tosylate is a potent p38 mitogen-activated protein kinase (MAPK) inhibitor. It was investigated for its anti-inflammatory effect in non-head injury trauma patients at risk for developing acute respiratory dist... |
|
T79260 |
MCI
|
|
Reactive Oxygen Species
|
|
MCI, a chemical compound demonstrating significant anti-inflammatory effects, particularly in collagen-induced arthritis (CIA) models, modulates inflammation through macrophage reprogramming by enhancing ROS scavenging a... |
|
T76786 |
Cabiralizumab
|
|
|
|
Cabiralizumab (FPA 008), an anti-CSF1R monoclonal antibody (MAb), promotes T cell infiltration and boosts antitumor immune responses. It also prevents osteoclast activation, thereby inhibiting bone destruction, and is ut... |
|
T73666 |
Proglumetacin
|
|
|
|
Proglumetacin, an orally active and potent cyclo-oxygenase inhibitor, inhibits the SARS-CoV Mpro (main protease of the SARS-CoV-2) with an AC50 of 8.9 μM, indicating its potential efficacy against SARS-CoV-2. It exhibits... |
|
T37606 |
Resolvin D5
|
7(S),17(S)-diHDHA |
|
|
Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid and docosahexaenoic acid . [1] In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory respons... |
