検索結果

Search Results for " serine-threonine "

ターゲット

Endogenous Metabolite Bradykinin Receptor

100

阻害剤

天然化合物

136

リコンビナントタンパク質

ライブラリー

カタログ番号	製品名	別名	ターゲット
TP1277	Bradykinin		Endogenous Metabolite , Bradykinin Receptor
	Bradykinin is an inflammatory mediator. It is a peptide that causes blood vessels to dilate (enlarge) via the release of prostacyclin, nitric oxide, and Endothelium-Derived Hyperpolarizing Factor. Bradykinin is a physiol...		Endogenous Metabolite , Bradykinin Receptor
T11666	IPR-803		Serine/threonin kinase
	IPR-803 is an effective inhibitor of the uPAR·uPA protein-protein interaction (PPI) with anti-tumor activity. IPR-803 binds directly to uPAR with a Ki of 0.2 μM.		Serine/threonin kinase
T11885	LSP-249		Others
	LSP-249 is a plasma kallikrein inhibitor under the study for angioedema, with an EC50 less than 100 nM in cell.		Others
T7017	WNK463		Serine/threonin kinase
	WNK463 is a pan-WNK-kinase inhibitor. It effectively inhibits the in vitro kinase activity of all four WNK family members (WNK1/2/3/4).		Serine/threonin kinase
T10547	BioE-1115		Serine/threonin kinase , Casein Kinase
			Serine/threonin kinase , Casein Kinase
T4058	R-IMPP		Others , Serine/threonin kinase
	R-IMPP is an inhibitor of PCSK9 translation. R-IMPP stimulates uptake of LDL-C in hepatoma cells by increasing LDL-R levels, without altering levels of secreted transferrin.		Others , Serine/threonin kinase
T8350	TPCK		Proteasome
	TPCK is an irreversible inhibitor of chymotrypsin-like proteases that affect cell proliferation, apoptosis, and tumorigenesis		Proteasome
T13257	Upamostat		PAI-1 , Serine/threonin kinase , Serine Protease
	Upamostat is an inhibitor of a serine protease and is a urokinase plasminogen activator (uPA) inhibitor.		PAI-1 , Serine/threonin kinase , Serine Protease
T4524	SBC-110736	SBC110736	Others , Serine/threonin kinase
	SBC-110736 is a proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitor		Others , Serine/threonin kinase
T9920	Evolocumab		Others
	Evolocumab is a human IgG2 monoclonal antibody that binds to human PCSK9 Proprotein Convertase Subtilisin Kexin Type 9).		Others
T13408	ZK824190		Others , Serine Protease
	ZK824190 is an orally available and selective inhibitor of urokinase plasminogen activator (uPA) as a potential treatment for multiple sclerosis(IC50s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively).		Others , Serine Protease
T14358	Avoralstat	BCX4161	Others
	Avoralstat (BCX4161) is an oral plasma kallikrein (PKK) inhibitor. Which is used for the treatment of hereditary angioedema.		Others
T9276	SBC-115337		Others , Serine/threonin kinase
	SBC-115337 is a PCSK9 inhibitor.		Others , Serine/threonin kinase
T8645	PF-06446846		Others
	PF 06446846 is a potent and selective PCSK9 inhibitor		Others
T2626	SBC-115076	SBC115076	Others , Serine/threonin kinase
	SBC-115076 is a potent extracellular proprotein convertase subtilisin kexin type 9 (PCSK9) antagonist.		Others , Serine/threonin kinase
T5456	WNK-IN-11	Allosteric WNK Kinase Inhibitor	Serine/threonin kinase
	WNK-IN-11 (Allosteric WNK Kinase Inhibitor) is an allosteric With-No-Lysine (WNK) kinase inhibitor,WNK1(IC50 : 4 nM)		Serine/threonin kinase
T8866	GW779439X		Apoptosis , Antibacterial , CDK , Aurora Kinase
	GW779439X is an inhibitor of CDK.		Apoptosis , Antibacterial , CDK , Aurora Kinase
T6370	AEBSF hydrochloride	AEBSF HCl,Pefabloc SC	Thrombin , Serine Protease , Influenza Virus
	AEBSF hydrochloride (Pefabloc SC) is an irreversible inhibitor of serine proteases, such as chymotrypsin, kallikrein, thrombin, plasmin, and trypsin.		Thrombin , Serine Protease , Influenza Virus
T8676	FOY 251		Others , Serine/threonin kinase , SARS-CoV
	FOY 251 is a proteinase inhibitor, and is an anti-proteolytic active metabolite camostate.		Others , Serine/threonin kinase , SARS-CoV
T8362	Benzamidine hydrochloride	Benzamidine HCl	Serine/threonin kinase , Serine Protease
	Benzamidine hydrochloride (Benzamidine HCl) is a reversible inhibitor of serine proteases, including trypsin, plasmin, and thrombin (Ki of 35, 350, and 220 μM, respectively).		Serine/threonin kinase , Serine Protease
T31206	Darexaban	YM 150,Darexaban, Tanexaban,YM150	Factor Xa
	Darexaban (Tanexaban, YM-150) is a direct inhibitor of Factor Xa.Darexaban and Darexaban glucuronide selectively and competitively inhibit FXA and inhibit prothrombin activity at the site of blood clot (thrombus) formati...		Factor Xa
T3359	Aprotinin	Bovine Pancreatic Trypsin Inhibitor,Traskolan,Antilysin	Others , Serine Protease , Influenza Virus , Proteasome
	Aprotinin (Traskolan) a broad-spectrum serine protease inhibitor, inhibiting the activity of a number of different esterases and proteases, including trypsin, chymotrypsin, kallikrein, plasmin, tissue plasminogen activat...		Others , Serine Protease , Influenza Virus , Proteasome
T2392	Nafamostat mesylate	FUT-175	Apoptosis , Serine/threonin kinase , SARS-CoV , Serine Protease
	Nafamostat mesylate (FUT-175), a synthetic serine protease inhibitor, has been used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic dermatitis.
T19763	Cetraxate hydrochloride	DV-1006,DV 1006,Cetraxate HCl,DV1006	Serine/threonin kinase
	Cetraxate hydrochloride (DV10062) is an oral gastrointestinal medication. It has a cytoprotective effect.		Serine/threonin kinase
T5125	LY3200882		TGF-beta/Smad
	LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).		TGF-beta/Smad
T8936	Proteinase K	proteinase K for tritirachium album,Protease K	Others
	Proteinase K (proteinase K for tritirachium album) is a nonspecific serine protease that is useful for general digestion of proteins. It is active in the presence of SDS or urea and over a wide range of pH (4-12), salt c...		Others
T2391	Camostat mesylate	FOY-S980,FOY305,Camostat mesilate	Serine/threonin kinase , SARS-CoV , Sodium Channel
	Camostat mesylate (FOY-S980) is a trypsin-like protease inhibitor and inhibits airway epithelial sodium channel (ENaC) function.		Serine/threonin kinase , SARS-CoV , Sodium Channel
T50103	NFAT Inhibitor-2		Others
	NFAT Inhibitor-2 is a compound used as a molecular building block.		Others
T3041	ALK inhibitor 2		FAK , ALK
	ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase.		FAK , ALK
T10285	ALK inhibitor 1		FAK , IGF-1R , ALK
	ALK inhibitor 1 is a selective ALK kinase inhibitor.		FAK , IGF-1R , ALK
T62684	ATM Inhibitor-5
	ATM Inhibitor-5 [formula (1)] is a potent inhibitor of the serine/threonine protein kinase ATM.
T9993	SBP-3264		Others
	SBP-3264 is a novel inhibitor of serine/threonine-protein kinases 3 and 4 (STK3 and STK4).		Others
T1911	Afuresertib	GSK2110183C,GSK2110183	ROCK , Akt , PKC
	Afuresertib (GSK2110183) is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity.		ROCK , Akt , PKC
T11942	MAP4K4-IN-3	Compound 17	MAPK
	MAP4K4-IN-3 (Compound 17) may be a viable target for antidiabetic agents, a serine/threonine protein kinase.		MAPK
T9589	SI-113		SGK
	SI-113 is a potent and selective inhibitor of SGK1, a serine/threonine protein kinase, that modulates several oncogenic signaling cascades.		SGK
T6095	JNJ-38877605		c-Met/HGFR
	JNJ-38877605 is an ATP-competitive c-Met inhibitor (IC50: 4 nM), 600-fold selective for c-Met than 200 other tyrosine and serine-threonine kinases.		c-Met/HGFR
T81417	PP5-IN-1		Apoptosis , Phosphatase
	PP5-IN-1 is a potent and competitive serine/threonine protein phosphatase-5 (PP5) inhibitor with potential anticancer activity that induces apoptosis in cancer cells.		Apoptosis , Phosphatase
T7151	GSK2982772		RIP kinase
	GSK2982772 is an inhibitor of receptor interacting serine/threonine kinase 1 (RIPK1)with IC50 values of 16 nM and 20 nM for human and monkey RIP1, respectively.		RIP kinase
T10727	Cdc7-IN-5		CDK
	Cdc7-IN-5 is a potent inhibitor of Cdc7 kinase. Cdc7, a serine-threonine protein kinase enzyme, is essential for the initiation of DNA replication in the cell cycle.		CDK
T77333L	(Iso)-BMT-124110 Formate	(R)-N-(8-((2-amino-2,4-dimethylpentyl)oxy)-5H-chromeno[3,4-c]pyridin-2-yl)acetamide Formate（1679370-98-9 Free base）	AAK1 (AP2 associated kinase 1)
	(Iso)-BMT-124110 Formate has an inhibitory effect on the protein serine/threonine kinase AAK, and is used in the treatment of Parkinson's disease, schizophrenia, neuropathic pain, and Alzheimer's disease.		AAK1 (AP2 associated kinase 1)
T60688	MKI-1	MASTL Kinase Inhibitor-1	Others
	MKI-1 (MASTL Kinase Inhibitor-1) is an inhibitor of MASTL (microtubule-associated serine/threonine kinase-like, IC50= 9.9 μM). MKI-1 exerts radiosensitizer and antitumor activities through PP2A activation in breast cance...		Others
T34973	Tyrphostin 8	4-Hydroxybenzylidenemalononitrile	EGFR , GTPase
	Tyrphostin 8(4-Hydroxybenzylidenemalononitrile) is a potent GTPase inhibitor that inhibits EGFR kinase with an IC50 of 560 μM.Tyrphostin 8 inhibits protein serine/threonine calmodulin phosphatases (IC50=21 μM), enhances ...		EGFR , GTPase
TP1875L	CDK2 acetate(255064-79-0 free base)		Others
	CDK2 acetate is a member of the eukaryotic S/T protein kinase family and its function is to catalyze the phosphoryl transfer of ATP γ-phosphate to serine or threonine hydroxyl (denoted as S0/T0) in a protein substrate.		Others
T6496	Vactosertib	TEW-7197,EW-7197	ALK , TGF-beta/Smad
	Vactosertib (EW-7197) is an orally bioavailable inhibitor of the serine/threonine kinase, transforming growth factor (TGF)-beta receptor type 1 (TGFBR1), also known as activin receptor-like kinase 5 (ALK5), with potentia...		ALK , TGF-beta/Smad
T3980	Su1498	Tyrphostin SU 1498,AG 1498	VEGFR
	Su1498 (Tyrphostin SU 1498) is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2 (VEGFR2, aka FLK1; IC50 = 700 nM), having negligible activity at several other serine/threonine and tyrosine kinases.1,...		VEGFR
T6904	Necrosulfonamide	(E)-Necrosulfonamide	MLK
	(E)-Necrosulfonamide ((E)-Necrosulfonamide) is an inhibitor of necroptosis. Blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during nec...		MLK
T10406	Tuvusertib	M1774,ATR inhibitor 1	Apoptosis , ATM/ATR , Others , Chk
	Tuvusertib (M1774) is an orally available ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor (Ki< 1 µΜ) with selective and potentially antitumor activity.Tuvusertib selectively inhibits ATR activity and blocks...		Apoptosis , ATM/ATR , Others , Chk
T9542	NS3861		AChR
	NS3861 is an agonist of nicotinic acetylcholine receptors (nAChRs) and bind with high affinity to heteromeric α3β4 and α4β2 nAChRs. NS3861 displays the β-subunit preference and a complete lack of activation at α4-contain...		AChR
T37185	D-(-)-3-Phosphoglyceric acid disodium	3-Phospho-D-glyceric acid disodium	Others
	D-(-)-3-Phosphoglyceric acid disodium (3-Phospho-D-glyceric acid disodium) is an intermediate in several biological pathways, most notably glycolysis/gluconeogenesis and the biosynthesis of serine, glycine, and threonine...		Others
T37207L	Cdk5 Substrate acetate		CDK
	Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine kinase that is predominantly active in neuronal tissues. With p25 or p35, Cdk5 phosphorylates a range of proteins, including histone H1 and tau. Cdk5 Substrate aceta...		CDK

Compounds

Bradykinin

TP1277

Synonym:

Target: Endogenous Metabolite, Bradykinin Receptor

IPR-803

T11666

Synonym:

Target: Serine/threonin kinase

Target: Serine/threonin kinase

BioE-1115

T10547

Synonym:

Target: Serine/threonin kinase, Casein Kinase

R-IMPP

T4058

Synonym:

Target: Others, Serine/threonin kinase

Target: PAI-1, Serine/threonin kinase, Serine Protease

SBC-110736

T4524

Synonym: SBC110736

Target: Others, Serine/threonin kinase

Target: Others, Serine Protease

Target: Others, Serine/threonin kinase

Target: Others, Serine/threonin kinase

WNK-IN-11

T5456

Synonym: Allosteric WNK Kinase Inhibitor

Target: Serine/threonin kinase

GW779439X

T8866

Synonym:

Target: Apoptosis, Antibacterial, CDK, Aurora Kinase

AEBSF hydrochloride

T6370

Synonym: AEBSF HCl,Pefabloc SC

Target: Thrombin, Serine Protease, Influenza Virus

FOY 251

T8676

Synonym:

Target: Others, Serine/threonin kinase, SARS-CoV

Benzamidine hydrochloride

T8362

Synonym: Benzamidine HCl

Target: Serine/threonin kinase, Serine Protease

Darexaban

T31206

Synonym: YM 150,Darexaban, Tanexaban,YM150

Target: Factor Xa

Aprotinin

T3359

Synonym: Bovine Pancreatic Trypsin Inhibitor,Traskolan,Antilysin

Target: Others, Serine Protease, Influenza Virus, Proteasome

Nafamostat mesylate

T2392

Synonym: FUT-175

Target: Apoptosis, Serine/threonin kinase, SARS-CoV, Serine Protease

Cetraxate hydrochloride

T19763

Synonym: DV-1006,DV 1006,Cetraxate HCl,DV1006

Target: Serine/threonin kinase

LY3200882

T5125

Synonym:

Target: TGF-beta/Smad

Proteinase K

T8936

Synonym: proteinase K for tritirachium album,Protease K

Target: Others

Camostat mesylate

T2391

Synonym: FOY-S980,FOY305,Camostat mesilate

Target: Serine/threonin kinase, SARS-CoV, Sodium Channel

Target: FAK, IGF-1R, ALK

Synonym: GSK2110183C,GSK2110183

Target: ROCK, Akt, PKC

Target: Apoptosis, Phosphatase

(Iso)-BMT-124110 Formate

T77333L

Synonym: (R)-N-(8-((2-amino-2,4-dimethylpentyl)oxy)-5H-chromeno[3,4-c]pyridin-2-yl)acetamide Formate（1679370-98-9 Free base）

Target: AAK1 (AP2 associated kinase 1)

MKI-1

T60688

Synonym: MASTL Kinase Inhibitor-1

Target: Others

Tyrphostin 8

T34973

Synonym: 4-Hydroxybenzylidenemalononitrile

Target: EGFR, GTPase

CDK2 acetate(255064-79-0 free base)

Synonym: TEW-7197,EW-7197

Target: ALK, TGF-beta/Smad

Su1498

T3980

Synonym: Tyrphostin SU 1498,AG 1498

Target: VEGFR

Necrosulfonamide

T6904

Synonym: (E)-Necrosulfonamide

Target: MLK

Tuvusertib

T10406

Synonym: M1774,ATR inhibitor 1

Target: Apoptosis, ATM/ATR, Others, Chk

D-(-)-3-Phosphoglyceric acid disodium

T37185

Synonym: 3-Phospho-D-glyceric acid disodium

Target: Others

Cdk5 Substrate acetate

T37207L

Synonym:

Target: CDK

カタログ番号	製品名	別名	ターゲット
TN2082	Pinostrobin		Beta Amyloid , IL Receptor , Serine/threonin kinase , TNF
	Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aα²(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting oxidative damage and calcium overload, as well as suppress...		Beta Amyloid , IL Receptor , Serine/threonin kinase , TNF
T5S0689	Demethylwedelolactone		Serine Protease
	Demethylwedelolactone is a natural product isolated from Eclipta alba, has trypsin inhibitory effect an IC50 of 3.0 μM. it exerts anti-invasive growth effect on breast cancer cells.		Serine Protease
T7444	6-(Dimethylamino)purine	N,N-Dimethyladenine	Serine/threonin kinase , CDK
	6-(Dimethylamino)purine (N,N-Dimethyladenine) is a serine threonine protein kinase and CDK inhibitor		Serine/threonin kinase , CDK
T4915	β-Glycerophosphate disodium salt hydrate		Phosphatase , Endogenous Metabolite
	β-Glycerophosphate is a classical serine-threonine phosphatase inhibitor used in kinase reaction buffers. BGP is often used in combination with other phosphatase/protease inhibitors for broad spectrum inhibition. It func...		Phosphatase , Endogenous Metabolite
T4713	Phosphorylcholine chloride calcium salt tetrahydrate	Phosphocholine chloride calcium salt tet,CalciuM Phosphorylcholine Tetrahydrate	Others , Endogenous Metabolite
	Phosphorylcholine chloride calcium salt tetrahydrate (Phosphocholine chloride calcium salt tet) is a small haptenic molecule, is found in a wide variety of organisms. Human hepatic tumors undergo an elevation in the conc...		Others , Endogenous Metabolite
T4839	Ac-Ala-OH	N-Acetylalanine,N-Acetyl-L-alanine	Others , Endogenous Metabolite
	Ac-Ala-OH (N-Acetyl-L-alanine) is a substrate for Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit, Myelin basic protein, GTP-binding nuclear protein Ran, Tropomyosin alpha 4 chain, HIV-1 Rev binding pro...		Others , Endogenous Metabolite
T4825	D-(+)-Xylose	D(+)-Xylose,(+)-Xylose,Wood sugar	Endogenous Metabolite
	D-(+)-Xylose (Wood sugar) is an aldopentose - a monosaccharide containing five carbon atoms and an aldehyde functional group. It has chemical formula C5H10O5 and is 40% as sweet as sucrose. Xylose is also found in mucopo...		Endogenous Metabolite
T19365	Hydroxypyruvic acid	3-Hydroxypyruvic acid,β-Hydroxypyruvic acid	Others
	Hydroxypyruvic acid is an intermediate in the metabolism of glycine, serine, and threonine. It is a substrate for serine-pyruvate aminotransferase and glyoxylate reductase/hydroxypyruvate reductase.		Others
T16381	Okadaic acid		Others
	Okadaic acid is a non-comepetitive, selective and reversible serine/threonine-specific protein phosphatases 1 (PP1), PP2A, and PP3 inhibitor (IC50s: 10-15 nM, 0.5 nM, and 4 nM, respectively). Okadaic acid is extracted fr...		Others

天然物製品

Pinostrobin

TN2082

Synonym:

Target: Beta Amyloid, IL Receptor, Serine/threonin kinase, TNF

Demethylwedelolactone

T5S0689

Synonym:

Target: Serine Protease

6-(Dimethylamino)purine

T7444

Synonym: N,N-Dimethyladenine

Target: Serine/threonin kinase, CDK

β-Glycerophosphate disodium salt hydrate

T4915

Synonym:

Target: Phosphatase, Endogenous Metabolite

Phosphorylcholine chloride calcium salt tetrahydrate

T4713

Synonym: Phosphocholine chloride calcium salt tet,CalciuM Phosphorylcholine Tetrahydrate

Target: Others, Endogenous Metabolite

Ac-Ala-OH

T4839

Synonym: N-Acetylalanine,N-Acetyl-L-alanine

Target: Others, Endogenous Metabolite

D-(+)-Xylose

T4825

Synonym: D(+)-Xylose,(+)-Xylose,Wood sugar

Target: Endogenous Metabolite

Hydroxypyruvic acid

T19365

Synonym: 3-Hydroxypyruvic acid,β-Hydroxypyruvic acid

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-01059	BMPR2 Protein, Human, Recombinant (His)	Human	HEK293
	The bone morphogenetic protein type II receptor (BMPR-II, or BMPR2), a receptor for the transforming growth factor (TGF)-beta/bone morphogenetic protein (BMP) superfamily. Reduced expression or function of BMPR2 signalin...
TMPY-04407	LOK Protein, Human, Recombinant (His)	Human	E. coli
	Serine / threonine-protein kinase 1, also known as Lymphocyte-oriented kinase, STK1 and LOK, belongs to the protein kinase superfamily, STE Ser / Thr protein kinase family and STE2 subfamily. Protein kinases constitute a...
TMPY-04466	STK40 Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	STK40 is localized to both the cytoplasm and the nucleus. It is ubiquitously expressed. Mechanistically, Stk40 interacts with Rcn2, which also activates Erk1/2 to induce ExEn specification in mouse ESCs. Stk40 is able to...
TMPY-04374	MST4 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	MST4, also known as mammalian STE2-like protein kinase 4, is a novel member of the germinal center kinase subfamily of human Ste2-like kinases and is closely related to MST3. The 416 amino acid full-length MST4 contains ...
TMPY-04468	STK16 Protein, Human, Recombinant (His & NusA)	Human	E. coli
	Serine/threonine-protein kinase 16, also known as myristoylated and palmitoylated serine/threonine-protein kinase, Protein kinase PKL12, TGF-beta-stimulated factor 1, TSF-1, MPSK1 and STK16, is a membrane protein that is...
TMPY-04398	MST1 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	Dysregulation of MST1/STK4, a key kinase component of the Hippo-YAP pathway, is linked to the etiology of many cancers with poor prognosis. STK4/Hippo pathway may have important therapeutic implications for cancer. The t...
TMPH-00340	ATG1 Protein, Candida glabrata, Recombinant (His)	Candida glabrata	E. coli
	Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein ...
TMPH-03457	CAK1 Protein, S. cerevisiae, Recombinant (E. coli, His & Myc)	Saccharomyces cerevisiae	E. coli
	CAK1 Protein, S. cerevisiae, Recombinant (E. coli, His & Myc) is expressed in E. coli with N-terminal 10xHis tag and C-terminal Myc tag. The predicted molecular weight is 49.6 kDa. Accession number: P43568
TMPH-03456	CAK1 Protein, S. cerevisiae, Recombinant (His & Myc)	Saccharomyces cerevisiae	Baculovirus
	CAK1 Protein, S. cerevisiae, Recombinant (His & Myc) is expressed in Baculovirus with N-terminal 10xHis tag and C-terminal Myc tag. The predicted molecular weight is 46.1 kDa. Accession number: P43568
TMPY-05095	RAF1 Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	RAF1 gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds direct...
TMPJ-00944	PPP1CC Protein, Human, Recombinant (His)	Human	E. coli
	Serine/Threonine-Protein Phosphatase PP1-Υ Catalytic Subunit (PPP1CC) is a member of the PPP phosphatase family. It is essential for cell division, participates in the regulation of glycogen metabolism, muscle contractil...
TMPY-04424	MST3 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	Aberrant STK24 expression was an independent prognostic indicator in lung adenocarcinoma patients. Its dysregulation was associated with its DNA copy number alteration and methylation. STK24/CCM3-regulated exocytosis pla...
TMPY-02198	ILKAP Protein, Human, Recombinant (His)	Human	HEK293
	Integrin-linked kinase-associated serine/threonine phosphatase 2C, also known as ILKAP, is a cytoplasm protein that belongs to the PP2C family. ILKAP contains one PP2C-like domain. ILKAP is widely expressed. Highest leve...
TMPY-00683	BMPR2 Protein, Human, Recombinant (His & hFc)	Human	HEK293
	The bone morphogenetic protein type II receptor (BMPR-II, or BMPR2), a receptor for the transforming growth factor (TGF)-beta/bone morphogenetic protein (BMP) superfamily. Reduced expression or function of BMPR2 signalin...
TMPJ-00325	BMPR1A/ALK-3 Protein, Human, Recombinant (hFc & His)	Human	Human Cells
	Bone Morphogenetic Protein Receptor Type-1A (BMPR1A) belongs to the TKL Ser/Thr protein kinase family and TGFB receptor subfamily, including the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. BMPR1A i...
TMPJ-00304	ALK-1 Protein, Mouse, Recombinant (hFc)	Mouse	Human Cells
	Activin Receptor-Like Kinase 1 (ALK-1) is a type I cell-surface receptor for the TGF-β superfamily of ligands, which mediates signaling of BMP9 (bone morphogenetic protein) and BMP10. ALK1 signaling is necessary for angi...
TMPH-01171	CDK5 Protein, Human, Recombinant	Human	E. coli
	CDK5 Protein, Human, Recombinant is expressed in E. coli.
TMPH-01173	CDK7 Protein, Human, Recombinant	Human	E. coli
	CDK7 Protein, Human, Recombinant is expressed in E. coli.
TMPH-01172	CDK7 Protein, Human, Recombinant (His)	Human	Baculovirus
	CDK7 Protein, Human, Recombinant (His) is expressed in Baculovirus.
TMPY-04376	PLK1 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	Serine / threonine-protein kinase PLK1 / PLK-1, also known as polo-like kinase 1 (PLK-1) or serine / threonine-protein kinase 13 (STPK13), Polo-like kinases (PLKs), is a family of four serine / threonine protein kinases ...
TMPY-01168	ALK-1 Protein, Human, Recombinant (His)	Human	HEK293
	Activin A receptor, type II-like 1 (ACVRL1), also known as ALK-1 (activin receptor-like kinase 1), is an endothelial-specific type I receptor of the TGF-beta (transforming growth factor beta) receptor family of ligands. ...
TMPJ-00254	TGF beta 3 Protein, Human/Mouse/Rat, Recombinant	Human,Mouse,Rat	Human Cells
	Transforming growth factor beta 3(TGFB3) is a member of a TGF -β superfamily which is defined by theirstructural and functional similarities. TGFB3 is secreted as a complex with LAP. This latent form of TGFB3becomes acti...
TMPY-02953	TEM8/ANTXR1 Protein, Human, Recombinant (hFc)	Human	HEK293
	ANTXR1 contains 1 VWFA domain and belongs to the ATR family. ATR (Ataxia telangiectasia and Rad3 related) and ATM (Ataxia telangiectasia mutated) are closely related kinases that are activated by DNA damage. They are ser...
TMPY-04750	CSNK2A2 Protein, Human, Recombinant	Human	Baculovirus-Insect Cells
	Casein kinase II subunit alpha', also known as CSNK2A2 and CK2A2, is a member of the protein kinase superfamily, Ser/Thr protein kinase family and CK2 subfamily. Casein kinases are operationally defined by their prefer...
TMPY-04552	AKT1 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	v-akt murine thymoma viral oncogene homolog 1 (AKT1), or protein kinase B-alpha (PKB-ALPHA) is a serine-threonine protein kinase, belonging to the Protein Kinase Superfamily. AKT1 is a major mediator of the responses to ...
TMPY-04356	GSK3B Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	GSK3B is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It Contains 1 protein kinase domain, and is expressed in the testis, thymus, prostate, and ovary and weakly expressed in the lung, ...
TMPH-00009	OGT Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc...
TMPY-04565	SRPK3 Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	Serine / threonine-protein kinase SRPK3, also known as Muscle-specific serine kinase 1, Serine/arginine-rich protein-specific kinase 3, SR-protein-specific kinase 3, Serine / threonine-protein kinase 23, MSSK-1, SRPK3 an...
TMPH-03458	STE11 Protein, S. cerevisiae, Recombinant	Saccharomyces cerevisiae	E. coli
	Serine/threonine protein kinase required for cell-type-specific transcription and signal transduction in yeast. It is thought that it phosphorylates the STE7 protein kinase which itself, phosphorylates the FUS3 and or KS...
TMPY-04559	CDC42BPB Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	CDC42BPB is a member of the serine / threonine protein kinase family that contains a Cdc42 / Rsc-binding p21 binding domain similar to that of PAK kinase. The kinase domain of this protein is related to the myotonic dyst...
TMPY-03810	GALNT2 Protein, Human, Recombinant (His)	Human	HEK293
	GALNT2, also known as GalNAc-T2, is a member of the GalNAc-transferases family. Members of this family transfer an N-acetyl galactosamine to the hydroxyl group of a serine or threonine residue in the first step of O-link...
TMPJ-00256	Latent TGF-beta 3 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	Human Cells
	Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell type, developmental stage, or tissue conditions. There are...
TMPJ-00255	TGF beta 3 Protein, Human, Recombinant (Avi), Biotinylated	Human	Human Cells
	Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell type, developmental stage, or tissue conditions. There are...
TMPY-04560	VRK1 Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	VRK1 is a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. Serine/threonine protein kinases are tumor suppressor that controls the activity of AMP-activated protein kinase family me...
TMPY-04751	VRK1 Protein, Human, Recombinant	Human	Baculovirus-Insect Cells
	VRK1 is a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. Serine/threonine protein kinases are tumor suppressor that controls the activity of AMP-activated protein kinase family me...
TMPY-04438	PLK1 Protein, Mouse, Recombinant (His)	Mouse	Baculovirus-Insect Cells
	Serine / threonine-protein kinase PLK1 / PLK-1, also known as polo-like kinase 1 (PLK-1) or serine / threonine-protein kinase 13 (STPK13), Polo-like kinases (PLKs), is a family of four serine / threonine protein kinases ...
TMPY-04463	CDKL2 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	Cyclin-dependent kinase-like 2 (Cdkl2) is a member of cdc2-related serine / threonine protein kinase family and it is found expressed in various brain regions, including the cerebral cortex, entorinal cortex, hippocampus...
TMPY-04420	TLK1 Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	Tousled-like kinase 1 (or protein kinase ubiquitous, PKU-beta/TLK1) is a serine/threonine protein kinase that is implicated in chromatin remodeling, DNA replication and mitosis. TLK1 has a function important for proper c...
TMPK-00972	PK-1/PROK1 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	PK-1 (Ac10) is a baculovirus-encoded serine/threonine kinase,a pk-1 knockout AcMNPV failed to produce infectious progeny, while the pk-1 repair virus could rescue this defect.the kinase activity of PK-1 is essential in r...
TMPJ-01109	EIF4EBP2 Protein, Human, Recombinant (His)	Human	E. coli
	Eukaryotic Translation Initiation Factor 4E-Binding Protein 2 (EIF4EBP2) is a member of the Eukaryotic Translation Initiation Factor 4E Binding Protein Family. EIF4EBP2 regulates eIF4E activity by preventing its assembly...
TMPH-02180	TTBK2 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother cent...
TMPY-04357	RSK4 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	Ribosomal protein S6 kinase alpha-6, also known as Ribosomal S6 kinase 4, 9 kDa ribosomal protein S6 kinase 6,RSK-4, RSK4 and RPS6KA6, is a protein that belongs to the protein kinase superfamily, AGC Ser/Thr protein kina...
TMPY-04402	CSNK1G1 Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	Casein kinase I isoform gamma-1, also known as CSNK1G1, is a member of the protein kinase superfamily, CK1 Ser/Thr protein kinase family and casein kinase I subfamily. Thecasein kinase I family of protein kinases are ...
TMPY-04752	DCLK1 Protein, Human, Recombinant	Human	Baculovirus-Insect Cells
	DCAMKL1, also known as DCLK1, is a member of the protein kinase superfamily and the doublecortin family. It contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a...
TMPY-04404	DCLK1 Protein, Human, Recombinant (aa 1-705, His & GST)	Human	Baculovirus-Insect Cells
	DCAMKL1, also known as DCLK1, is a member of the protein kinase superfamily and the doublecortin family. It contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a...
TMPH-02648	PKDCC Protein, Mouse, Recombinant (His & Myc)	Mouse	Baculovirus
	Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is essential for patterning at organogenesis stages. Mediates phosphorylati...
TMPH-02899	VRK1 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream targe...
TMPK-00677	PKA/PRKACA Protein, Canine, Recombinant (His)	Canine	E. coli
	The cAMP-dependent protein kinase PKA is a well-characterized member of the serine-threonine protein AGC kinase family and is the effector kinase of cAMP signaling. As such, PKA is involved in the control of a wide varie...
TMPH-01539	ILK Protein, Human, Recombinant (His)	Human	Baculovirus
	Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered ...
TMPY-04372	CK2 alpha/CSNK2A1 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	Casein kinase II subunit alpha, also known as CK II alpha, CSNK2A1 and CK2A1, is a member of the protein kinase superfamily, Ser / Thr protein kinase family and CK2 subfamily. Casein kinase II (CSNK2A1) is a serine / thr...
------------------------ More ------------------------

BMPR2 Protein, Human, Recombinant (His)

TMPY-01059

Species: Human

Expression System: HEK293

LOK Protein, Human, Recombinant (His)

TMPY-04407

Species: Human

Expression System: E. coli

STK40 Protein, Human, Recombinant (His & GST)

TMPY-04466

Species: Human

Expression System: Baculovirus-Insect Cells

MST4 Protein, Human, Recombinant (GST)

TMPY-04374

Species: Human

Expression System: Baculovirus-Insect Cells

STK16 Protein, Human, Recombinant (His & NusA)

TMPY-04468

Species: Human

Expression System: E. coli

MST1 Protein, Human, Recombinant (His)

TMPY-04398

Species: Human

Expression System: Baculovirus-Insect Cells

ATG1 Protein, Candida glabrata, Recombinant (His)

TMPH-00340

Species: Candida glabrata

Expression System: E. coli

CAK1 Protein, S. cerevisiae, Recombinant (E. coli, His & Myc)

TMPH-03457

Species: Saccharomyces cerevisiae

Expression System: E. coli

CAK1 Protein, S. cerevisiae, Recombinant (His & Myc)

TMPH-03456

Species: Saccharomyces cerevisiae

Expression System: Baculovirus

RAF1 Protein, Human, Recombinant (His & GST)

TMPY-05095

Species: Human

Expression System: Baculovirus-Insect Cells

PPP1CC Protein, Human, Recombinant (His)

TMPJ-00944

Species: Human

Expression System: E. coli

MST3 Protein, Human, Recombinant (His)

TMPY-04424

Species: Human

Expression System: Baculovirus-Insect Cells

ILKAP Protein, Human, Recombinant (His)

TMPY-02198

Species: Human

Expression System: HEK293

BMPR2 Protein, Human, Recombinant (His & hFc)

TMPY-00683

Species: Human

Expression System: HEK293

BMPR1A/ALK-3 Protein, Human, Recombinant (hFc & His)

TMPJ-00325

Species: Human

Expression System: Human Cells

ALK-1 Protein, Mouse, Recombinant (hFc)

TMPJ-00304

Species: Mouse

Expression System: Human Cells

CDK5 Protein, Human, Recombinant

TMPH-01171

Species: Human

Expression System: E. coli

CDK7 Protein, Human, Recombinant

TMPH-01173

Species: Human

Expression System: E. coli

CDK7 Protein, Human, Recombinant (His)

TMPH-01172

Species: Human

Expression System: Baculovirus

PLK1 Protein, Human, Recombinant (His)

TMPY-04376

Species: Human

Expression System: Baculovirus-Insect Cells

ALK-1 Protein, Human, Recombinant (His)

TMPY-01168

Species: Human

Expression System: HEK293

TGF beta 3 Protein, Human/Mouse/Rat, Recombinant

TMPJ-00254

Species: Human,Mouse,Rat

Expression System: Human Cells

TEM8/ANTXR1 Protein, Human, Recombinant (hFc)

TMPY-02953

Species: Human

Expression System: HEK293

CSNK2A2 Protein, Human, Recombinant

TMPY-04750

Species: Human

Expression System: Baculovirus-Insect Cells

AKT1 Protein, Human, Recombinant (His)

TMPY-04552

Species: Human

Expression System: Baculovirus-Insect Cells

GSK3B Protein, Human, Recombinant (His)

TMPY-04356

Species: Human

Expression System: Baculovirus-Insect Cells

OGT Protein, Human, Recombinant (His & SUMO)

TMPH-00009

Species: Human

Expression System: E. coli

SRPK3 Protein, Human, Recombinant (His & GST)

TMPY-04565

Species: Human

Expression System: Baculovirus-Insect Cells

STE11 Protein, S. cerevisiae, Recombinant

TMPH-03458

Species: Saccharomyces cerevisiae

Expression System: E. coli

CDC42BPB Protein, Human, Recombinant (His & GST)

TMPY-04559

Species: Human

Expression System: Baculovirus-Insect Cells

GALNT2 Protein, Human, Recombinant (His)

TMPY-03810

Species: Human

Expression System: HEK293

Latent TGF-beta 3 Protein, Human, Recombinant (His & Avi), Biotinylated

TMPJ-00256

Species: Human

Expression System: Human Cells

TGF beta 3 Protein, Human, Recombinant (Avi), Biotinylated

TMPJ-00255

Species: Human

Expression System: Human Cells

VRK1 Protein, Human, Recombinant (His & GST)

TMPY-04560

Species: Human

Expression System: Baculovirus-Insect Cells

VRK1 Protein, Human, Recombinant

TMPY-04751

Species: Human

Expression System: Baculovirus-Insect Cells

PLK1 Protein, Mouse, Recombinant (His)

TMPY-04438

Species: Mouse

Expression System: Baculovirus-Insect Cells

CDKL2 Protein, Human, Recombinant (His)

TMPY-04463

Species: Human

Expression System: Baculovirus-Insect Cells

TLK1 Protein, Human, Recombinant (His & GST)

TMPY-04420

Species: Human

Expression System: Baculovirus-Insect Cells

PK-1/PROK1 Protein, Mouse, Recombinant (hFc)

TMPK-00972

Species: Mouse

Expression System: HEK293

EIF4EBP2 Protein, Human, Recombinant (His)

TMPJ-01109

Species: Human

Expression System: E. coli

TTBK2 Protein, Human, Recombinant (His & Myc)

TMPH-02180

Species: Human

Expression System: E. coli

RSK4 Protein, Human, Recombinant (GST)

TMPY-04357

Species: Human

Expression System: Baculovirus-Insect Cells

CSNK1G1 Protein, Human, Recombinant (His & GST)

TMPY-04402

Species: Human

Expression System: Baculovirus-Insect Cells

DCLK1 Protein, Human, Recombinant

TMPY-04752

Species: Human

Expression System: Baculovirus-Insect Cells

DCLK1 Protein, Human, Recombinant (aa 1-705, His & GST)

TMPY-04404

Species: Human

Expression System: Baculovirus-Insect Cells

PKDCC Protein, Mouse, Recombinant (His & Myc)

TMPH-02648

Species: Mouse

Expression System: Baculovirus

VRK1 Protein, Mouse, Recombinant (His & Myc)

TMPH-02899

Species: Mouse

Expression System: E. coli

PKA/PRKACA Protein, Canine, Recombinant (His)

TMPK-00677

Species: Canine

Expression System: E. coli

ILK Protein, Human, Recombinant (His)

TMPH-01539

Species: Human

Expression System: Baculovirus

CK2 alpha/CSNK2A1 Protein, Human, Recombinant (GST)

TMPY-04372

Species: Human

Expression System: Baculovirus-Insect Cells

--------- More ---------

カタログ番号	製品名
L1400	MAPK Inhibitor Library	365 compounds
	A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;
L1300	PI3K-AKT-mTOR Compound Library	420 compounds
	A unique collection of 420 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved with PI3K/Akt/mTOR signaling;

ライブラリー

MAPK Inhibitor Library

L1400

Compounds: 365

PI3K-AKT-mTOR Compound Library

L1300

Compounds: 420