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TP1978L |
NFAT inhibitor, Cell Permeable aceate
|
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Others
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NFAT inhibitor, Cell Permeable aceate is a cell-permeable nuclear factor of activated T cells (NFAT) inhibitor. It can be used for the research of podocyte and diabetic nephropathy. |
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T1908 |
MHY1485
|
|
mTOR
,
Autophagy
|
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MHY1485 is a mTOR activator. It inhibits the autophagic process by inhibition of fusion between autophagosomes and lysosomes, leading to the accumulation of LC3II protein and enlarged autophagosomes. |
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T5399 |
GeA-69
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PARP
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GeA-69 (GeA69) is a selective and allosteric PARP14 macrodomain 2 (MD2) inhibitor (Kd: 0.86 μM in ITC assays). |
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T9230 |
KM 91104
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ATPase
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KM 91104 is a cell permeable inhibitor of V-ATPase. KM91104 specifically targets the interaction between V-ATPase subunit A3 and subunit B2. |
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T12079 |
ML604440
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Proteasome
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ML604440 is a cell permeable proteasome β1i (LMP2) subunit inhibitor. |
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T7149 |
S29434
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NADPH
,
Autophagy
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S29434 (NMDPEF) is a potent, competitiveinhibitor of quinone reductase 2 (QR2;IC50:5-16nM). |
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T10363 |
Arazine
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N-Acetyl-S-farnesyl-L-cysteine |
Others
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Arazine (N-Acetyl-S-farnesyl-L-cysteine) can be a a substrate for isoprenylcysteine methyltransferase by competing with prenylated G protein or its receptors site. Arazine is a cell-permeable modulator of G protein and G... |
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T1923 |
BRD4770
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Histone Methyltransferase
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BRD4770 is a histone methyltransferase G9a inhibitor and induces cell senescence. |
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TP1978 |
11R-VIVIT
|
NFAT inhibitor, Cell Permeable |
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NFAT inhibitor. Inhibits LPS or LPS plus IFN-γ-induced IL-12 p40, IL-12 p70, IL-23 and TNF secretion from bone marrow-derived macrophages (BMDMs). Also attenuates NO production and Nos2 mRNA expression in LPS-stimulated ... |
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TP1015 |
NFAT Inhibitor
|
VIVIT peptide |
Others
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NFAT Inhibitor (VIVIT peptide) is a cell-permeable compound that selectively inhibits calcineurin-mediated dephosphorylation of NFAT. |
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T16409 |
OSMI-1
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|
Others
,
Acyltransferase
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OSMI-1 is an O-GlcNAc transferase (OGT) inhibitor (IC50=2.7 μM) that is orally active and cell-permeable. OSMI-1 inhibits protein O-GlcNA acetylation without qualitatively altering cell-surface N- or O- linked glycans. |
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T3058 |
(Z)-SMI-4a
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TCS PIM-1 4a,SMI-4a |
Pim
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(Z)-SMI-4a (TCS PIM-1 4a) is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM. |
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T20684 |
2',7'-Dichlorofluorescein diacetate
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Diacetyldichlorofluorescein,Leuco-dcf diacetate,Dcfh-DA,DCFDA |
Others
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2',7'-Dichlorofluorescein diacetate (Diacetyldichlorofluorescein), a cell-permeable fluorogenic probe, is useful for the detection of nitric oxide (NO) and reactive oxygen species (ROS) and for the determination of the d... |
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T31900 |
GA3-AM
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|
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GA3-AM is a cell permeable chemical dimerizer. |
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T25526 |
IGP-1
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iGP1 |
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iGP-1 is a cell-permeable mitochondrial sn-Glycerol 3-phosphate dehydrogenase (mGPDH) inhibitor. |
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T39989L |
JQKD82 trihydrochloride
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Histone Demethylase
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JQKD82 trihydrochloride, a cell-permeable and selective inhibitor of KDM5, enhances H3K4me3 levels and is utilized in multiple myeloma research. |
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T12942L |
SN50 acetate (213546-53-3 free base)
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NF-κB
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SN50 acetate is a cell permeable inhibitor of NF-κB translocation. |
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T12261 |
NSC232003
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E1/E2/E3 Enzyme
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NSC232003 is a highly potent and cell-permeable inhibitor of UHRF1. |
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T2417 |
Sal003
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Apoptosis
,
Phosphatase
,
PERK
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Sal003, an effective cell-permeable analog, inhibitis the eIF2α phosphatase. |
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T23588 |
9-CP-Ade Mesylate
|
9-Cyclopentyladenine monomethanesulfonate,9 CP Ade Mesylate,9CPAde Mesylate |
AChR
|
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9-CP-Ade Mesylate (9 CP Ade Mesylate) is a cell-permeable, stable and non-competitive inhibitor of adenylate cyclase. |
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T11337 |
Fumarate hydratase-IN-1
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Mitochondrial Metabolism
|
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Fumarate hydratase-IN-1 is a cell-permeable fumarate hydratase inhibitor with antiproliferative activity and can be used to study cellular activity. |
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T21634 |
N-Oxalylglycine
|
Oxalylglycine |
Others
|
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N-Oxalylglycine (Oxalylglycine) is a cell permeable inhibitor of α-ketoglutarate-dependent enzymes. |
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T6432 |
Calpeptin
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Apoptosis
,
Cysteine Protease
,
Proteasome
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Calpeptin is a potent, cell-permeable calpain inhibitor. |
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T2451 |
GlyH-101
|
GlyH 101 |
CFTR
,
Autophagy
|
|
GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM. |
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T4026 |
SU5408
|
VEGFR2 Kinase Inhibitor I |
VEGFR
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SU5408 (VEGFR2 Kinase Inhibitor I) is a potent, cell-permeable inhibitor of the VEGFR2 kinase. |
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T4216 |
STAT5-IN-1
|
STAT5 Inhibitor |
STAT
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STAT5-IN-1 (STAT5 Inhibitor) is a cell-permeable inhibitor which suppresses Stat5 via binding to the SH2 domain. |
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T7389 |
G15
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Estrogen Receptor/ERR
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G15 is a cell-permeable non-steroidal antagonist of GPER (Ki = 20 nM) |
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T10937L |
D-JNKI-1 acetate
|
D-JNKI-1 acetate(1445179-97-4 Free base),AM-111 acetate |
JNK
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D-JNKI-1 acetate (AM-111 acetate) is a highly potent and cell-permeable peptide inhibitor of JNK. |
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T17148 |
TPPB
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PKC
|
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TPPB is a kinase C activator of cell-permeable benzolactam-derived protein (Ki: 11.9 nM). |
|
T4048 |
Monastrol
|
(±)-Monastrol |
Apoptosis
,
Kinesin
|
|
Monastrol ((±)-Monastrol) is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5. |
|
T6629 |
PYR-41
|
PYR41,PYR 41 |
Apoptosis
,
E1/E2/E3 Enzyme
|
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PYR-41 is the first cell-permeable inhibitor of ubiquitin-activating enzyme E1, with no activity at E2. |
|
TQ0003 |
740 Y-P
|
740YPDGFR,PDGFR 740Y-P |
PI3K
,
Autophagy
|
|
740 Y-P (740YPDGFR) is a potent and cell-permeable activator of PI3K. |
|
T3144 |
BML-284
|
Wnt agonist 1 |
Wnt/beta-catenin
|
|
BML-284 (Wnt agonist 1) is a potent, selective and , cell-permeable Wnt signaling activator. |
|
T2432 |
PD 169316
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|
Virus Protease
,
p38 MAPK
,
Autophagy
|
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PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor. |
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T19323 |
Fluorescein diacetate
|
3,6-Diacetoxyfluoran,Di-O-acetylfluorescein |
Others
|
|
Fluorescein diacetate (Di-O-acetylfluorescein) is a cell permeable esterase-substrate for hGSTP1-1. |
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T8823 |
Locostatin
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Raf
|
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Locostatin is a potent and cell permeable inhibitor of Raf kinase inhibitor protein (RKIP)/Raf1 kinase interaction and an inhibitor of cell migration. |
|
T2502 |
INH1
|
IBT13131 |
Apoptosis
,
Microtubule Associated
|
|
INH1 (IBT13131) is a cell-permeable Hec1 inhibitor that specifically disrupts the Hec1/Nek2 interaction. |
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T1563 |
Nifuroxazide
|
Diarlidan,Nifuroxazid,Dicoferin |
Antibacterial
,
Antibiotic
,
STAT
|
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Nifuroxazide (Diarlidan) is an orally available and cell-permeable nitrofuran-based antidiarrheal agent. It has the inhibitory effect against the activation of cellular STAT1/3/5 transcription. |
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T21807 |
INCA-6
|
Triptycene-1,4-quinone |
Others
|
|
INCA-6 (Triptycene-1,4-quinone) is a cell-permeable NFAT inhibitor. INCA-6 inhibits of CN-NFAT signaling by targeting of NFAT(P) substrate to the calcineurin (CN) phosphatase site. |
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TP1955L |
PKC β pseudosubstrate acetate
|
Protein kinase C beta pseudosubstrate,PKC beta pseudosubstrate,PKC β pseudosubstrate acetate (172308-76-8 Free base) |
PKC
|
|
PKC β pseudosubstrate acetate (PKC β pseudosubstrate acetate (172308-76-8 Free base)) is a selective cell-permeable inhibitor of PKC. |
|
T1973 |
PFI-4
|
PFI4 |
Epigenetic Reader Domain
|
|
PFI-4 is a potent and selective and cell-permeable BRPF1 bromodomain inhibitor. |
|
T2661 |
TGX-221
|
TGX221 |
PI3K
|
|
TGX-221, an effective, specific, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit, is utilized for cancer treatment. |
|
T2002 |
PF-4708671
|
PF4708671 |
S6 Kinase
,
Autophagy
|
|
PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) .In cell-free assays, PF-4708671(PF4708671) is potent for S6K1(Ki50=20 nM, IC50=160 nM). |
|
T15019 |
CUR61414
|
|
Hedgehog/Smoothened
|
|
CUR61414 is a cell-permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM) and selectively binds to smoothened (Ki = 44 nM). |
|
T5130 |
DBET6
|
|
Apoptosis
,
Epigenetic Reader Domain
|
|
dBET6 is a selective and cell-permeable degrader of BET based on PROTAC (IC50: 14 nM). It has antitumor activity. |
|
T19011L |
Hoechst 34580 xHCl(23555-00-2(free base)
|
HOE 34580 xHCl |
Beta Amyloid
|
|
Hoechst 34580 xHCl(23555-00-2(free base) is a cell-permeable fluorescent dye, is used for staining DNA and nuclei. |
|
T22195 |
CBFβ Inhibitor
|
5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine |
DNA/RNA Synthesis
|
|
CBFβ Inhibitor (5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine) is a cell-permeable CBFβ inhibitor and inhibits its association with Runx1. |
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T4125 |
HSF1A
|
|
HSP
|
|
HSF1A is a cell-permeable activator of HSF1 that protects mammalian cells against stress-induced apoptosis. |
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T12327 |
OSMI-3
|
|
Others
|
|
|
|
TP1921L1 |
Autocamtide-2-related inhibitory peptide, myristoylated acetate(201422-04-0 free base)
|
|
CaMK
,
Autophagy
|
|
Autocamtide-2-related inhibitory peptide, myristoylated acetate is a CaM kinase II inhibitor; enhanced cell permeable derivative of Autocamtide-2-related inhibitory peptide. |
