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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T83625 | iNOS-IN-14 | 3-bromo-1H-indazole-7-carbonitrile | NOS |
iNOS-IN-14 (3-bromo-1H-indazole-7-carbonitrile) is a potent nitric oxide synthase (NOS) inhibitor that inhibits the NADPH oxidase activity of nNOS. | |||
T72638 | iNOS inhibitor-10 | NO Synthase | |
iNOS Inhibitor-10, with an IC50 of 65 nM, exhibits antiproliferative effects on triple-negative breast cancer cells [1]. | |||
T62849 | iNOS-IN-2 | ||
iNOS-IN-2 (Compound 53) is a potent inducible nitric oxide synthase (iNOS) protein down-regulator. iNOS-IN-2 effectively inhibits NO production (IC50: 6.4 μM). iNOS-IN-2 can be used in studies of chronic inflammation. | |||
T62987 | iNOs-IN-1 | ||
iNOs-IN-1 (YPW) is a potent inhibitor of inducible nitric oxide synthase (iNOS) with anti-inflammatory effects. iNOs-IN-1 significantly inhibits IL-6 and iNOS expression in a dose-dependent manner in murine macrophages, ... | |||
T63261 | iNOs-IN-3 | ||
iNOs-IN-3 is an orally active nitric oxide synthase (iNOS) inhibitor with an IC50 value of 3.342 μM that exhibits anti-inflammatory effects and can be used to study LPS-induced acute lung injury (ALI). | |||
T63104 | iNOS/PGE2-IN-1 | ||
iNOS/PGE2-IN-1 is an iNOS/PGE2 inhibitor and a potent anti-inflammatory agent. iNOS/PGE2-IN-1 exhibits an inhibitory effect on LPS-induced NO production and has a low ulcerogenic potential. | |||
T21700 | NOS-IN-1 | 2-Imino-4-methylpiperidine (acetate) | NOS |
NOS-IN-1 (2-Imino-4-methylpiperidine acetate) is a potent and orally active inhibitor of NO synthase (NOS) isoforms. NOS-IN-1 exhibits IC50s of 0.1 μM, 0.2 μM, and 1.1μM for human iNOS (hiNOS), hnNOS and heNOS, respectiv... | |||
T19916 | TRIM | 1-(2-Trifluoromethylphenyl)imidazole | NOS |
TRIM (1-(2-Trifluoromethylphenyl)imidazole) is an inhibitor of nNOS. | |||
T1127 | Beclometasone dipropionate | Beclovent,Beclomethasone dipropionate,Beconase,Vancenase | Glucocorticoid Receptor |
Beclometasone dipropionate (Vancenase) is the dipropionate ester of a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and cell entry, beclomethasone... | |||
T22419 | S-Methylisothiourea sulfate | (S)-Methylisothiourea sulfate | NOS , NO Synthase , HSV |
S-Methylisothiourea sulfate ((S)-Methylisothiourea sulfate) is a potent and selective inhibitor of iNOS and exerts beneficial effects in rodent models of septic shock[1]. | |||
T23046 | N-tert-butyl-α-Phenylnitrone | (Z)-N-benzylidene-2-Methylpropan-2-aMine oxide | ROS , COX |
N-tert-butyl-α-Phenylnitrone ((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) inhibits COX2 catalytic activity. N-tert-butyl-α-Phenylnitrone((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) possesses potent reactive oxyge... | |||
T4509 | Inositol nicotinate | Inositol niacinate,Hexanicotol,Myo-Inositol hexanicotinate,Mesotal,Dilexpal,Inositol hexanicotinate | Others |
Inositol nicotinate (Mesotal) has the effect of lowering cholesterol and expanding peripheral blood vessels for hypercholesterolemia and atherosclerosis. | |||
T7621 | 6-Thioinosine | 6-Mercaptopurine riboside,6TI | Nucleoside Antimetabolite/Analog |
6-Thioinosine (6TI) is a purine antimetabolite, acts as an anti-adipogenesis agent. | |||
T27083 | Crebinostat | Epigenetic Reader Domain , Histone Acetyltransferase , HDAC | |
Crebinostat is a potent histone deacetylase (HDAC) inhibitor, inhibiting HDAC1, HDAC2, HDAC3, and HDAC6 with IC50s of 0.7 nM, 1.0 nM, 2.0 nM, and 9.3 nM, respectively.Crebinostat increases the density of synapsin-1 punct... | |||
T12516 | Polyinosinic-polycytidylic acid sodium | Poly(I:C) sodium | Apoptosis , Others , TLR |
Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MD... | |||
T3661 | Citarinostat | ACY241,HDAC-IN-2 | HDAC |
ACY-241, also known as Citarinostat (ACY241), is a potent, selective and orally available histone deacetylase (HDAC) inhibitor, with potential antineoplastic activity. Upon oral administration, ACY-241 inhibits the activ... | |||
T6233 | Entinostat | SNDX-275,MS-275 | Apoptosis , HDAC , Autophagy |
Entinostat (MS-275) (MS-275) is an inhibitor of HDACs that inhibits HDAC1 and HDAC3 (IC50s: 0.18/0.74 μM). | |||
T16729 | Remetinostat | SHP-141 | HDAC |
Remetinostat (SHP-141), a hydroxamic acid-based inhibitor of histone deacetylase enzymes, is currently being developed for the treatment of cutaneous T-cell lymphoma. | |||
T4477 | Domatinostat tosylate | 4SC-202 tosylate,4SC-202 | Apoptosis , HDAC |
Domatinostat tosylate (4SC-202) is a selective inhibitor of class I HDAC for HDAC1/2/3 (IC50: 1.20/1.12/0.57 μM). It also displays inhibitory activity against Lysine-specific demethylase 1 (LSD1). | |||
T6055 | Quisinostat | JNJ-26481585 | Apoptosis , HDAC , Autophagy |
Quisinostat (JNJ-26481585) (JNJ-26481585) is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM, modest potent to HDACs 2, 4, 10, and 11; greater than 30-fold selectivity against... | |||
T4481 | Tucidinostat | HBI-8000,Chidamide,CS 055 | HDAC |
Tucidinostat (Chidamide) is an effective and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, less active on HDAC8/11 (IC50: 733/432 nM), and sho... | |||
T6279L | Givinostat hydrochloride | ITF2357 hydrochloride,Givinostat HCl,ITF2357,ITF 2357,ITF-2357,ITF2357 HCl | HDAC |
Givinostat hydrochloride (ITF2357 hydrochloride) is an inhibitor of HDAC with IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat hydrochloride exhibits anti-inflammatory, anti-angiogenic, and antineopla... | |||
T2454 | Dacinostat | NVP-LAQ824,LAQ824 | HDAC , Autophagy |
LAQ824 (Dacinostat (NVP-LAQ824)) is a novel HDAC inhibitor with IC50 of 32 nM and is an activator of the p21 promoter. | |||
T6481 | Droxinostat | NS 41080 | Apoptosis , HDAC |
Droxinostat (NS 41080) is a selective inhibitor of HDAC, mostly for HDACs 6 and 8 with IC50 of 2.47 μM and 1.46 μM, greater than 8-fold selective against HDAC3 and no inhibition to HDAC1, 2, 4, 5, 7, 9, and 10. | |||
T1852 | Rac-Belinostat | NSC726630,PXD101,PX-105684 | HDAC |
Rac-Belinostat (PX-105684) is a novel hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity. Belinostat targets HDAC enzymes, thereby inhibiting tumor cell proliferation, inducing apoptos... | |||
T2383 | Panobinostat | NVP-LBH589,LBH589 | Apoptosis , HIV Protease , HDAC , Autophagy |
Panobinostat (NVP-LBH589) is a broad-spectrum HDAC inhibitor (IC50=5 nM) with oral activity and non-selectivity. Panobinostat has antitumor activity and induces apoptosis and autophagy. | |||
T2078 | Fimepinostat | CUDC-907,PI3K/HDAC Inhibitor,CUDC 907 | Apoptosis , PI3K , HDAC |
Fimepinostat (CUDC 907) is an orally bioavailable inhibitor of both phosphoinositide 3-kinase (PI3K) class I and pan-histone deacetylase (HDAC) enzymes, with potential antineoplastic activity. Upon oral administration, C... | |||
T2512 | Mocetinostat | MGCD0103,MG0103 | Apoptosis , HDAC , Autophagy |
Mocetinostat (MG0103) is an orally available HDAC inhibitor with most potency for HDAC1 (IC50: 0.15 μM), 2- to 10- fold selectivity against HDAC2/3/11. | |||
T4370 | Resminostat hydrochloride | 4SC-201 hydrochloride,RAS2410 hydrochloride | HDAC |
Resminostat hydrochloride (RAS2410 hydrochloride) is an effective inhibitor of HDAC1/HDAC3/HDAC6 (IC50: 42.5/50.1/71.8 nM), respectively, and shows less potent activities against HDAC8 (IC50: 877 nM). | |||
TNU0810 | 2′-C-Methyl-6-O-methylinosine | 2′-C-Methyl-6-O-methylinosine | Nucleoside Antimetabolite/Analog |
2′-C-Methyl-6-O-methylinosine (2′-C-Methyl-6-O-methylinosine) is a hypoxanthine analog with a wide range of physical activities for the study of a variety of tumor diseases. | |||
TNU0187 | 2',5-Difluoro-2'-deoxy-1-arabinosyluracil | 2'-Deoxy-2'-fluoro-5-fluoro-arabinouridine | Nucleoside Antimetabolite/Analog |
2',5-Difluoro-2'-deoxy-1-arabinosyluracil (2'-Deoxy-2'-fluoro-5-fluoro-arabinouridine) is a urinary pyrimidine nucleoside analogue with potential antiepileptic and antihypertensive activity, which can be used to study an... | |||
T1583 | Vorinostat | MK0683,suberoylanilide hydroxamic acid,SAHA | Apoptosis , Mitophagy , Virus Protease , HDAC , Autophagy |
Vorinostat (SAHA) is a pan-histone deacetylase (HDAC) inhibitor (IC50=10 nM) with inhibitory activity against HDAC1/2/3/6/7/11. Vorinostat has antitumor activity, induces cell differentiation, blocks the cell cycle and i... | |||
T0020 | Sodium 4-aminosalicylate dihydrate | Sodium 4-Aminosalicylate,4-Amino-salicylic acid sodium salt | Free radical scavengers , NF-κB , Antibacterial , Antibiotic |
Sodium 4-aminosalicylate dihydrate (4-Amino-salicylic acid sodium salt) is the sodium salt form of aminosalicylic acid, an analog of para-aminobenzoic acid (PABA) with antitubercular activity. Sodium 4-aminosalicylate di... | |||
T0598 | Iminostilbene | Dibenzazepine | Others |
Iminostilbene (Dibenzazepine) (Dibenzazepine) is a chemical precursor of carbamazepine which is used primarily in the treatment of epilepsy and neuropathic pain. | |||
T0431 | Abexinostat | CRA 24781,PCI24781,PCI-24781,PCI 24781,CRA 024781 | HDAC |
PCI-24781 (Abexinostat (PCI24781)) is a new pan-HDAC inhibitor mainly targeting HDAC1 (Ki: 7 nM), also have moderate inhibitory for HDACs 2, 3, 6, and 10 and greater than 40-fold selectivity against HDAC8. Phase 1/2. | |||
T17028 | Tefinostat | CHR-2845 | HDAC |
Tefinostat (CHR-2845) is a potent monocyte/macrophage-targeted histone deacetylase (HDAC) inhibitor. Tefinostat is cleaved to the active acid CHR-2847 by the intracellular esterase human carboxylesterase-1 (hCE-1).Tefino... | |||
T3614 | Inosine pranobex | Groprinosin,Isoprinosine,Immunovir,Delimmun | IL Receptor , HIV Protease |
Inosine pranobex (Delimmun) has a number of immunomodulatory effects, including inducing T-lymphocyte differentiation, augmenting macrophage and NK cell functions, and stimulating IL-2 production. Through these effects a... | |||
T6362 | Domatinostat | 4SC202,4SC 202,4SC-202 (free base),4SC-202 | Apoptosis , HDAC |
Domatinostat (4SC202) is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. Also displays inhibitory activity against Lysine specific demethylase 1 (L... | |||
T6865 | Quisinostat dihydrochloride | Quisinostat 2HCl,Quisinostat (JNJ-26481585) 2HCl,JNJ26854165(Quisinostat) 2HCl,JNJ-26481585 2HCl | Apoptosis , HDAC , Autophagy |
Quisinostat dihydrochloride (JNJ26854165(Quisinostat) 2HCl) is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM in a cell-free assay, modest potent to HDACs 2, 4, 10, and 11; g... | |||
T1890 | Pracinostat | SB939 | Apoptosis , HDAC |
Pracinostat (SB939) is a novel HDAC inhibitor with improved in vivo properties compared to other HDAC inhibitors currently in Clinicalal trials, allowing oral dosing. Data demonstrate that Pracinostat is a potent and eff... | |||
T6279 | Givinostat hydrochloride monohydrate | ITF2357,ITF-2357 hydrochloride monohydrate,Givinostat,Gavinostat hydrochloride monohydrate | HDAC |
Givinostat hydrochloride monohydrate (ITF2357) is an HDAC inhibitor. | |||
T8551 | Nitrobenzylthioinosine | NBMPR | AChR , Adenosine Receptor |
Nitrobenzylthioinosine (NBMPR) is an inhibitor of ENT1 transporter that binds to ENT1 transporter with high affinity. | |||
T71138L | Binospirone | MDL 73005EF | 5-HT Receptor |
Binospirone (MDL 73005EF) is a 5-HT1A receptor agonist with anxiolytic activity used in the study of glaucoma and movement disorders associated with neurologic dysfunction. | |||
TNU0442 | 2’-beta-C-Methyl inosine | 2'-C-Methylinosine | Antiviral , DNA/RNA Synthesis |
2’-beta-C-Methyl inosine (2’-C-Methylinosine) is an HCV RNA polymerase inhibitor with antiviral activity and is being studied for the treatment of hepatitis C virus infection. | |||
T23171 | Polyinosinic-polycytidylic acid | Poly(I:C) | TLR |
Polyinosinic-polycytidylic acid (Poly(I:C)) is a double-stranded RNA (dsRNA) and a TLR3 agonist. Polyinosinic-polycytidylic acid induces natural immunity in mammals. | |||
T9835 | 4-QUinolinecarboxamide, N-[3-[[[2-[4-(aminosulfonyl)phenyl]ethyl]amino]carbonyl]phenyl]-1,2-dihydro-2-oxo- | Others | |
4-QUinolinecarboxamide, N-[3-[[[2-[4-(aminosulfonyl)phenyl]ethyl]amino]carbonyl]phenyl]-1,2-dihydro-2-oxo- is an amine. | |||
T2489 | Ricolinostat | ACY-1215,Rocilinostat | Apoptosis , HDAC |
Ricolinostat (Rocilinostat) is an orally bioavailable, specific inhibitor of histone deacetylase 6 (HDAC6) with potential antineoplastic activity. | |||
T8517 | Belinostat | PX105684,PXD101,PXD-101 | HDAC , Autophagy |
Belinostat (PXD101) is an inhibitor of hydroxamic acid-type histone deacetylase (HDAC, IC50 of 27 nM in HeLa cell extracts),and with antineoplastic activity. | |||
T1296 | 4-Aminosalicylic acid | Aminosalicylic acid,4-aminosalicylate,para-aminosalicylic acid,Aminopar | NF-κB , Lipoxygenase , COX , Glutathione Peroxidase , Antibacterial , Antibiotic |
4-Aminosalicylic acid (para-aminosalicylic acid) is an analog of para-aminobenzoic acid (PABA) with antitubercular activity. | |||
T125614 | Clematiunicinoside D | ||
Clematiunicinoside D is a useful organic compound for research related to life sciences. The catalog number is T125614 and the CAS number is 1699748-21-4. |
カタログ番号 | 製品名 | 別名 | ターゲット |
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T6S1665 | Irisflorentin | Others , NO Synthase | |
1. Irisflorentin blocks apoptosis pathways, by exerting its effects by promoting rpn-3 expression to enhance the activity of proteasomes and down-regulating egl-1 expression. 2. Irisflorentin has anti-inflammatory mechan... | |||
T2738 | Dehydroandrographolide | NOS , Influenza Virus | |
Dehydroandrographolide is a natural compound extracted from herbal medicine Andrographis paniculata (Burm f) Nees. | |||
TN6951 | Ethyl linoleate | Others | |
Ethyl linoleate is a natural product. | |||
T6S1572 | Sauchinone | ERK , p38 MAPK , NF-κB | |
1. Sauchinone is a useful adjunctive treatment for bacterial infection. 2. Sauchinone, an active lignan found in Saururus chinensis, to regulate the activation of HSCs, to prevent liver fibrosis, and to inhibit oxidative... | |||
TN2139 | Regaloside B | NOS , COX , NO Synthase | |
Regaloside B, a phenylpropanoid isolated from Lilium longiflorum, exhibits anti-inflammatory activity by inhibiting the expression of iNOS (inducible nitric oxide synthase) and COX-2 (cyclooxygenase-2). | |||
T0610 | Piceatannol | trans-Piceatannol,Astringenin | Apoptosis , Serine/threonin kinase , PKA , Syk , PKC , Autophagy |
Piceatannol (Astringenin) is an anti-inflammatory, immunomodulatory and antiproliferative agent. It inhibits p56lck and syk protein tyrosine kinases and inhibits NF-κB activation and gene expression of TNF-induced. It is... | |||
T5S0045 | Isofraxidin | 6,8-Dimethoxyumbelliferone,Phytodolor | MMP , ERK , p38 MAPK , TLR , COX |
1. Isofraxidin (Phytodolor) protects leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in a p53-independent manner. 2. Isofraxidin has a protective effect against LPS-induced ALI, and the prote... | |||
T1079 | Metronidazole | Flagyl,Metronidazol,Anagiardil | Apoptosis , NADPH , Hydrogenase , Antibacterial , Antibiotic , Parasite , Antifection |
Metronidazole (Metronidazol) is a synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities. | |||
TCS2170 | 2,5-Dihydroxyacetophenone | Quinacetophenone,2-Acetylhydroquinone,2-5-dihydroxyacetophenone,Acetylhydroquinone,DHAP | ERK , NF-κB , Tyrosinase |
1. 2,5-Dihydroxyacetophenone (Quinacetophenone) possess anti-anxiety, and neuroprotective qualities. 2. 2,5-Dihydroxyacetophenone (Quinacetophenone) reatment can induce a sustained activation of JNK, ERK1/2, and p38 MAPK... | |||
TN1109 | 3-O-Acetyl-16α-hydroxydehydrotrametenolic acid | 3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid | NOS , NO Synthase , Prostaglandin Receptor |
3-O-Acetyl-16α-hydroxydehydrotrametenolic acid (3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid) shows anti-inflammatory activity, it can inhibit NO production and iNOS expression in LPS-stimulated Raw264.7 cells. | |||
T4897 | Inosine-5'-triphosphate trisodium salt | ITP,Inosine 5'-triphosphate trisodium salt | Others , Endogenous Metabolite |
Inosine-5'-triphosphate trisodium salt (ITP) is used in studies on the impact of deamination of ATP and GTP by various enzymes and chemical processes. Inosine-5'-triphosphate trisodium salt (ITP) may be used as a substra... | |||
TN3861 | Dihydropinosylvin | Anti-infection | |
Dihydropinosylvinin is an phytoalexin, it shows antifungal activity against Cladosporium cladosporioides, Botryodiplodia theobromae, Aspergillus niger and Penicillium schlerotgenum, it also exhibits strong antibacterial ... | |||
T3755 | Pinostilbene | Others | |
Pinostilbene obviously attenuates the phosphorylation of c-Jun and JNK triggered by 6-OHDA. | |||
TN1808 | Isovitexin 2''-O-arabinoside | Others | |
Isovitexin 2''-O-arabinoside is a flavonoid found in the alfalfa plant. | |||
T5S2228 | 6‴-Feruloylspinosin | 6'''-Feruloylspinosin | NF-κB |
6‴-Feruloylspinosin (6'''-Feruloylspinosin) may possess anti-inflammatory activity. | |||
T4685 | INOSINIC ACID | Inosine 5′-monophosphate,IMP,I-5'-P | Endogenous Metabolite |
Inosinic acid (IMP) is a purine nucleotide which has hypoxanthine as the base and one phosphate group esterified to the sugar moiety. Inosinic acid is a nucleotide present in muscle and other tissues. It is formed by the... | |||
T4818 | Thyminose | 2-Deoxy-D-ribose,2-Deoxy-D-arabinose,2-Deoxy-D-erythropentose | Others , Endogenous Metabolite |
Thyminose (2-Deoxy-D-arabinose) induces Apoptosis by inhibiting the synthesis and increasing the efflux of glutathione. | |||
T5S1679 | Acetylshengmanol Arabinoside | Acetylcimigenol 3-O-alpha-L-arabinopyran | Others |
Acetylcimigenol 3-O-alpha-L-arabinopyranoside is an extract derived from Cimicifuga. | |||
TN6910 | Aloinoside B | 11-o-Rhamnosylaloin B | |
Aloinoside B (11-o-Rhamnosylaloin B) is a glycoside from aloe vera. | |||
T5796 | Plantainoside D | Isoplantamajoside | RAAS , PKC |
Plantainoside D (Isoplantamajoside) shows potent antioxidative effects as those of ascorbic acid, it shows angiotensin-converting enzyme (ACE) inhibitory inhibitory activity in vitro with the IC(50) value of 2.17 mM, it ... | |||
T0437 | Inosine | INO 495,NSC 20262 | ROS , Endogenous Metabolite , Adenosine Receptor |
Inosine (NSC-20262) is a purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It has immunomodulatory, neuroprotective, and analgesic properties. | |||
T1709 | 2'-Deoxyinosine | Guanine deoxyriboside,Deoxyinosine | Others , Endogenous Metabolite |
2'-Deoxyinosine (Guanine deoxyriboside) inhibits the growth of human colon-carcinoma cell lines and is associated with purine nucleoside phosphorylase (PNP) deficiency. | |||
T2S0112 | Yibeinoside A | Sinpeinine-3-O-β-glucoside | Others |
Yibeinoside A (Sinpeinine-3-O-β-glucoside) is an alkaloid from Fritillaria pallidiflora. | |||
TN1487 | Chrysin 6-C-arabinoside 8-C-glucoside | Others | |
Chrysin 6-C-arabinoside 8-C-glucoside and chrysin-6-C-glucosyl-8-C-arabinoside are α±-glucosidase inhibitors, α±-glucosidase inhibitors are widely used in the treatment of type 2 diabetes. | |||
T8144 | Raffinose | Melitose,Melitriose | Others , Endogenous Metabolite |
Raffinose (Melitriose) is an indigestible short-chain oligosaccharide, a trisaccharide composed of galactose, glucose and fructose, found in many plants. It can be hydrolyzed by α-galactosidase (α-GAL) to D-galactose and... | |||
T8012 | Scyllo-Inositol | Scyllitol | Beta Amyloid , Endogenous Metabolite |
Scyllo-Inositol (Scyllitol) is one of the inositol stereoisomers, rare in the nature, and expected as a promising disease-modifying therapeutic agent for Alzheimer's disease. | |||
TN1488 | Chrysin 6-C-glucoside 8-C-arabinoside | Others | |
Chrysin 6-C-glucoside 8-C-arabinoside and Chrysin-6-C-arabinosyl-8-C-glucoside are α±-glucosidase inhibitors, α±-glucosidase inhibitors are widely used in the treatment of type 2 diabetes. | |||
TN2083 | Pinostrobin chalcone | ||
Pinostrobin chalcone, a chalcone analog isolated from the leguminous plant, Mucuna pruriens, exhibits anticancer activity with an IC50 value of 20.42±2.23 μg/mL against MDA-MB-231 and 22.51±0.42 μg/mL against the HT-29 c... | |||
T13752 | L-(+)-Arabinose | Endogenous Metabolite | |
L-(+)-Arabinose selectively inhibits intestinal sucrase activity in a non-competitive manner, inhibiting glucose elevation caused by sucrose intake. | |||
T0421 | I-Inositol | Inositol,myo-Inositol,meso-Inositol | Endogenous Metabolite |
i-Inositol (myo-Inositol) is a intracellular phosphate compound, involved in cell signaling and may stimulate tumor cell differentiation. | |||
T4875 | Palatinose hydrate | 6-O-α-D-Glucopyranosyl-D-fructose, Isoma | Others , Endogenous Metabolite |
Palatinose hydrate (6-O-α-D-Glucopyranosyl-D-fructose, Isoma) is a disaccharide having an α(1→6) linkage between D-glucose and D-fructose and is similar to sucrose in its physicochemical properties. It is produced from s... | |||
T5073 | Inosine 5'-monophosphate disodium salt hydrate | Inosine 5'-monophosphate disodium salt,5'-IMP-Na2,Disodium 5'-inosinate monohydrate | Others , Endogenous Metabolite |
Inosine 5'-monophosphate disodium salt hydrate (Inosine 5'-monophosphate disodium salt), or inosinic acid, is the ribonucleotide of hypoxanthine and the first nucleotide formed during purine synthesis. | |||
T5915 | D-chiro-Inositol | D-(+)-CHIRO-INOSITOL | Endogenous Metabolite |
D-chiro-Inositol (D-(+)-CHIRO-INOSITOL) is an epimer of myo-inositol that is found in certain mammalian glycosylphosphatidylinositol protein anchors and inositol phosphoglycans possessing insulin-like bioactivity. | |||
T9076 | Spinosad | Others | |
Spinosad is a naturally-occurring insecticide found in the the soil bacterium S. spinosa. It is a mixture of the macrocyclic lactones spinosyn A and spinosyn D, which act as agonists of insect nicotinic acetylcholinester... | |||
T67867 | Mycaminosyltylonolide | Antibacterial | |
Mycaminosyltylonolide is a macrolide antibiotic that is tylonolide having a beta-D-mycaminosyl residue attached at position 5. Mycaminosyltylonolide is a potent antibiotic with antibacterial activity and inhibits lucifer... | |||
T21495 | Spinosyn A | Others | |
Spinosyn A is a polyketide-derived macrolide produced by Saccharopolyspora spinosa and is an active ingredient in several commercial insecticides. | |||
T19083 | 1-Methylinosine | N1-Methylinosine,Inosine, 1-methyl | Nucleoside Antimetabolite/Analog , Endogenous Metabolite |
1-Methylinosine (N1-Methylinosine) is a modified nucleotide found at position 37 in tRNA 3' to the anticodon of eukaryotic tRNA and has a role as a metabolite. | |||
TN1836 | Kudinoside D | LDL , AMPK , PPAR | |
Kudinoside D exerts anti-adipogenic effects through modulation of adipogenic transcription factors via AMPK signaling pathway. | |||
TN6745 | PALATINOSE | TNP-470,Isomaltulose | Others |
PALATINOSE (TNP-470) is a natural occurring disaccharide composed of alpha-1,6-linked glucose and fructose。 PALATINOSE has a beneficial effect on liver metabolic functions and might therefore be a good substitute for suc... | |||
TMS1830 | Disodium 5'-inosinate | Disodium Inosinate,Sodium Inosinate,5'-IMP disodium salt | Others |
Disodium 5'-inosinate (5'-IMP disodium salt) is a flavor agent. | |||
T3843 | Pinosylvin | 3,5-stilbenediol,5-Styrylresorcinol | Apoptosis , Others , Antibacterial , Autophagy |
Pinosylvin (5-Styrylresorcinol) induces autophagy via AMPK activation. Pinosylvin is likely to act as a pro-angiogenic factor. | |||
T0588 | D-(-)-Arabinose | D(-)-Arabinose,D-arabinose | Others |
D-(-)-Arabinose is a reducing sugar useful as a substrate in analysis of arabinose isomerases and synthesis of D-erythroascorbic acid in yeast. It shows strong growth inhibition against the Caenorhabditis elegans with an... | |||
T3S0309 | D(+)-Raffinose pentahydrate | D-Raffinose pentahydrate,Raffinose | Others , Endogenous Metabolite |
D(+)-Raffinose pentahydrate (D-Raffinose pentahydrate) is a trisugar composed of fructose, galactose and glucose that occurs naturally in a variety of vegetables and grains. D(+)-Raffinose pentahydrate is a functional ol... | |||
T6S2227 | Spinosin | Flavoayamenin | Others |
1. Spinosin (Flavoayamenin) ameliorated memory impairment induced through AβO, the serotonergic neurotransmitter system, and these effects were regulated, in part, through neuroprotective activity via the anti-inflammato... | |||
TN2082 | Pinostrobin | Beta Amyloid , IL Receptor , Serine/threonin kinase , TNF | |
Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aα²(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting oxidative damage and calcium overload, as well as suppress... | |||
T7523 | Guanidinosuccinic acid | Others , Endogenous Metabolite | |
Guanidinosuccinic acid (GSA) has been identified as a uremic toxin, is a nitrogenous metabolite isolated in excess from serum and urine. | |||
T4882 | Arabinose | DL-Arabinose | Others , Endogenous Metabolite |
Arabinose (DL-Arabinose), also known as (+/-)-arabinose or aloe sugar. Arabinose has been primarily detected in feces. Within the cell, Arabinose is primarily located in the cytoplasm. Arabinose exists in all eukaryotes,... | |||
T2S0461 | D-Arabinose | Others , Endogenous Metabolite | |
Inexpensive starting material for chiral synthesis. | |||
T0646 | 5-Aminosalicylic Acid | Mesalazine,5-ASA,Mesalamine | NF-κB , Lipoxygenase , COX , Glutathione Peroxidase , Endogenous Metabolite , PAK , PPAR |
5-Aminosalicylic Acid (5-ASA) is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the active moiety of SULPHASALAZINE. | |||
TN5594 | Tinosporol B | ||
Tinosporol B is a natural product for research related to life sciences. The catalog number is TN5594 and the CAS number is 2244777-13-5. | |||
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カタログ番号 | 製品名 | Species | Expression System |
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TMPH-03169 | PLC-H Protein, Pseudomonas aeruginosa, Recombinant (His & Myc & SUMO) | Pseudomonas aeruginosa | E. coli |
Hydrolyzes sphingomyelin in addition to phosphatidylcholine. PLC-H Protein, Pseudomonas aeruginosa, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted... | |||
TMPH-00167 | L-arabinose isomerase Protein, Bacillus subtilis, Recombinant (His & Myc) | Bacillus subtilis | E. coli |
Catalyzes the conversion of L-arabinose to L-ribulose. L-arabinose isomerase Protein, Bacillus subtilis, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecu... | |||
TMPH-02034 | Retinoschisin Protein, Human, Recombinant (His) | Human | E. coli |
Retinoschisin Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPH-03407 | NIFH Protein, Rhizobium leguminosarum, Recombinant (GST & His & Myc) | Rhizobium leguminosarum | E. coli |
The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein. NIFH Protein, Rhizobium leguminosarum, Recombinant (GST... | |||
TMPH-00045 | Aln g I Protein, Alnus glutinosa, Recombinant (E. coli, His) | Alnus glutinosa | E. coli |
Aln g I Protein, Alnus glutinosa, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 21.2 kDa and the accession number is P38948. | |||
TMPY-03172 | Argininosuccinate lyase Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells |
The recycling of citrulline by argininosuccinate synthase 1 (ASS1) and argininosuccinate lyase (ASL) is crucial to maintain arginine availability and nitric oxide (NO) production. Nitric oxide (NO) plays an established r... | |||
TMPH-03177 | RhlR Protein, Pseudomonas aeruginosa, Recombinant (His & Myc & SUMO) | Pseudomonas aeruginosa | E. coli |
Necessary for transcriptional activation of the rhlAB genes encoding the rhamnosyltransferase. It also functions as a transcriptional activator of elastase structural gene (lasB). Binds to autoinducer molecules BHL (N-bu... | |||
TMPH-03173 | OprF Protein, Pseudomonas aeruginosa, Recombinant (His) | Pseudomonas aeruginosa | E. coli |
Has porin activity, forming small water-filled channels. Also has a structural role in determining cell shape and ability to grow in low-osmolarity medium. OprF Protein, Pseudomonas aeruginosa, Recombinant (His) is expre... | |||
TMPH-03171 | Lysyl endopeptidase Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO) | Pseudomonas aeruginosa | E. coli |
Lysine-specific endoprotease. Involved in corneal virulence. Lysyl endopeptidase Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted mo... | |||
TMPH-03179 | LpxC Protein, Pseudomonas aeruginosa, Recombinant (His & Myc & SUMO) | Pseudomonas aeruginosa | E. coli |
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis. LpxC Protein, Pseudomonas aeruginosa, Recombinant (His & Myc... | |||
TMPH-03178 | TusA Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO) | Pseudomonas aeruginosa | E. coli |
Sulfur carrier protein which probably makes part of a sulfur-relay system. TusA Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted mol... | |||
TMPH-03172 | OprI Protein, Pseudomonas aeruginosa, Recombinant (His) | Pseudomonas aeruginosa | E. coli |
OprI Protein, Pseudomonas aeruginosa, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 12.9 kDa and the accession number is P11221. | |||
TMPH-03164 | Beta-lactamase OXA-10 Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO) | Pseudomonas aeruginosa | E. coli |
Hydrolyzes both carbenicillin and oxacillin. Beta-lactamase OXA-10 Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight... | |||
TMPH-03167 | ToxR Protein, Pseudomonas aeruginosa, Recombinant (His) | Pseudomonas aeruginosa | E. coli |
Positive regulation of toxA gene transcription. toxR Protein, Pseudomonas aeruginosa, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 32.9 kDa and the acces... | |||
TMPH-03174 | LecA Protein, Pseudomonas aeruginosa, Recombinant (His) | Pseudomonas aeruginosa | E. coli |
D-galactose specific lectin. Binds in decreasing order of affinity: melibiose, methyl-alpha-D-galactoside, D-galactose, methyl-beta-D-galactoside, N-acetyl-D-galactosamine. Similar to plant lectins in its selective (carb... | |||
TMPH-03176 | LasA Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO) | Pseudomonas aeruginosa | E. coli |
LasA Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 36.0 kDa and the accession number is P14789. | |||
TMPH-03165 | Beta-lactamase Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO) | Pseudomonas aeruginosa | E. coli |
Beta-lactamase Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 56.7 kDa and the accession number is P24735. | |||
TMPH-03166 | Elastase Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO) | Pseudomonas aeruginosa | E. coli |
Cleaves host elastin, collagen, IgG, and several complement components as well as endogenous pro-aminopeptidase. Autocatalyses processing of its pro-peptide. Processes the pro-peptide of pro-chitin-binding protein (cbpD)... | |||
TMPH-03180 | LpxC Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO) | Pseudomonas aeruginosa | E. coli |
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis. LpxC Protein, Pseudomonas aeruginosa, Recombinant (His & SUM... | |||
TMPH-03168 | Exotoxin A Protein, Pseudomonas aeruginosa, Recombinant (His & KSI) | Pseudomonas aeruginosa | E. coli |
An NAD-dependent ADP-ribosyltransferase (ADPRT). Catalyzes the transfer of the ADP ribosyl moiety of oxidized NAD (NAD(+)) onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis. Has an LD(50) of 65... | |||
TMPH-03175 | Porin P Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO) | Pseudomonas aeruginosa | E. coli |
Anion specific, the binding site has higher affinity for phosphate than chloride ions. Porin O has a higher affinity for polyphosphates (tripolyphosphate and pyrophosphate) while porin P has a higher affinity for orthoph... | |||
TMPH-00046 | Aln g I Protein, Alnus glutinosa, Recombinant (Yeast, His) | European alder | P. pastoris (Yeast) |
Aln g I Protein, Alnus glutinosa, Recombinant (Yeast, His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 19.2 kDa and the accession number is P38948. | |||
TMPH-00346 | Limulus clotting factor C Protein, Carcinoscorpius rotundicauda, Recombinant (His) | Carcinoscorpius rotundicauda | E. coli |
This enzyme is closely associated with an endotoxin-sensitive hemolymph coagulation system which may play important roles in both hemostasis and host defense mechanisms. Its active form catalyzes the activation of factor... | |||
TMPH-03170 | PvdA Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO) | Pseudomonas aeruginosa | E. coli |
PvdA Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 65.5 kDa and the accession number is Q51548. | |||
TMPH-01552 | IRF1 Protein, Human, Recombinant (GST & His) | Human | Baculovirus Insect Cells |
Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections,... |
カタログ番号 | 製品名 | ||
---|---|---|---|
L2900 | Oxidation-Reduction Compound Library | 1264 compounds | |
1264 small molecule compounds with pro-oxidant or anti-oxidant activity for high-throughput and high-content screening. |