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Search Results for " CYP3A4 "

116

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T64037	CYP3A4-IN-2
	CYP3A4-IN-2 is a specific inhibitor of cytochrome P450 3A4 (CYP3A4) (IC50: 0.055 μM). CYP3A4-IN-2 is a ritonavir analogue with a more hydrophobic R2 side group and stronger inhibition than ritonavir. CYP3A4-IN-2 is capab...
T64032	CYP3A4-IN-3
	CYP3A4-IN-3 is a specific, highly affinity cytochrome P450 3A4 (CYP3A4) (cytochrome P450 3A4 (CYP3A4)) inhibitor (IC50: 0.075 μM). CYP3A4-IN-3 is an analogue of ritonavir with a simpler structure and twice as much inhibi...
T63954	CYP3A4-IN-1
	CYP3A4-IN-1 is a potent inhibitor of cytochrome P450 3A4 (CYP3A4) (IC50: 0.085 μM).
T20626	Esomeprazole		Proton pump , Cysteine Protease
	Esomeprazole is the S-isomer of omeprazole, inhibits the lysosomal cysteine protease legumain to prevent cancer metastasis. Esomeprazole is a proton pump inhibitors (PPI).		Proton pump , Cysteine Protease
T10423	AWZ1066S		Parasite
	AWZ1066S is a highly specific anti-Wolbachia drug candidate for the short-course treatment of filariasis (EC50: 2.5 nM in cell assay).		Parasite
T28827	Sofpironium bromide	BBI4000,BBI 4000,BBI-4000	Others , AChR
	Sofpironium bromide (BBI4000) belongs to a class of drugs called anticholinergics, which exert their effect by blocking the action of acetylcholine.		Others , AChR
T4697	ABBV-744	ABBV744	Epigenetic Reader Domain , HIV Protease
	ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2/3/4. It is used in the research on inflammatory diseases, cancer, and AIDS.		Epigenetic Reader Domain , HIV Protease
T9054	RO6889678		HBV
	RO6889678 is HBV inhibitor with a complex ADME profile.		HBV
T2397	Topiroxostat	FYX-051	P450 , ROS , Xanthine Oxidase
	Topiroxostat (FYX-051) is a selective xanthine oxidase inhibitor developed for treatment and management of hyperuricemia and gout.		P450 , ROS , Xanthine Oxidase
T1434	Clarithromycin	A-56268	P450 , ribosome , MRP , Antibacterial , Antibiotic , Autophagy
	Clarithromycin (A-56268) is a Macrolide Antimicrobial. The mechanism of action of clarithromycin is as a Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 3A Inhibitor, and P-Glycoprotein Inhibitor. The chemical classif...
T6150	TAK-715		p38 MAPK , Casein Kinase , JNK
	TAK-715 is a p38 MAPK inhibitor for p38α.		p38 MAPK , Casein Kinase , JNK
T2686L	Esomeprazole Sodium	(S)-Omeprazole sodium	ATPase , Proton pump
	Esomeprazole Sodium ((S)-Omeprazole sodium) is the S-isomer of omeprazole with selective and irreversible proton pump inhibitor activity.Esomeprazole acts as an exosome inhibitor by blocking the exosome release via the i...		ATPase , Proton pump
T21404	Fluticasone furoate	Veramyst,Allermist,Avamys,Fluticasone furoate	Glucocorticoid Receptor
	Fluticasone furoate (Avamys) is a synthetic trifluorinated corticosteroid derived from fluticasone with a Kd of 0.3 nM. Fluticasone furoate has potent anti-inflammatory, anti-asthmatic activity, and low systemic exposure...		Glucocorticoid Receptor
T1290	Oxiconazole nitrate	Ro 13-8996	Others , Antibiotic , Antifection , Antifungal
	Oxiconazole nitrate (Ro 13-8996) is the nitrate salt form of oxiconazole, a broad spectrum imidazole derivative with antifungal activity. Although the exact mechanism of action has yet to be fully elucidated, oxiconazole...		Others , Antibiotic , Antifection , Antifungal
T10989	Dehydroaripiprazole	OPC-14857,DM-14857	5-HT Receptor
	Dehydroaripiprazole (DM-14857) is the active metabolite of aripiprazole. Aripiprazole is an antipsychotic drug, which is metabolized by CYP3A4 and CYP2D6 and mainly forms dehydroaripiprazole. Dehydroaripiprazole has anti...		5-HT Receptor
T12146	N-Desmethyl-Apalutamide	N-Desmethyl Apalutamide	P450 , Androgen Receptor
	N-Desmethyl-Apalutamide is a less potent antagonist of the androgen receptor, is an active Apalutamide metabolite.		P450 , Androgen Receptor
T20656	Verapamil	NSC 135784,NSC-135784,CP-16533-1,(±)-Verapamil	P450 , Calcium Channel , P-gp
	Verapamil (CP-16533-1) is a calcium channel blocker and an orally active and effective inhibitor of P-gp. Verapamil inhibits CYP3A4 and can be used in studies about the treatment of high blood pressure, heart arrhythmias...		P450 , Calcium Channel , P-gp
T1010	Verapamil hydrochloride	Manidon,(±)-Verapamil hydrochlorid,Verapamil HCl,Calcan hydrochloride	P450 , Calcium Channel , P-gp
	Verapamil hydrochloride (Verapamil HCl) is a calcium channel blocker that is a class IV anti-arrhythmia agent.		P450 , Calcium Channel , P-gp
T77698	HCYP3A4 Fluorogenic substrate 1		Others
	hCYP3A4 Fluorogenic substrate 1 is a phthalimide derivative and shows low activity against COX.		Others
T79343	HCYP3A4-IN-1
	hCYP3A4-IN-1 (compound C6) is a potent, orally active inhibitor of hCYP3A4, exhibiting IC50 values of 43.93 nM in human liver microsomes (HLMs) and 153.00 nM in the CHO-3A4 stably transfected cell line. It competitively ...
T4498	Stiripentol	BCX2600,Diacomit	P450
	Stiripentol (BCX2600) (STP) is an anticonvulsant agent, which can inhibit N-demethylation of CLB to NCLB mediated by CYP3A4 (noncompetitively) and CYP2C19 (competitively) with Ki of 1.59/0.516 μM and IC50 of 1.58/3.29 μM...		P450
T21548	PF-4981517	CYP3cide	P450
	PF-4981517 (CYP3cide) is a efficient, specific and time-dependent inhibitor of cytochrome P4503A4 (CYP3A4). The IC 50 values for CYP3A activity are 0.03 μM,17 μM, and 71 μM for CYP3A4, CYP3A5, and CYP3A7, respectively. P...		P450
T0679	Ketoconazole	R-41400,Xolegel,(±)-Ketoconazol,Extina	NADPH-oxidase , P450 , Hydroxylase , Antifungal , Ras
	Ketoconazole (R-41400), a CYP3A4 inhibitor, is an imidazole anti-fungal agent.		NADPH-oxidase , P450 , Hydroxylase , Antifungal , Ras
T7618	Pyributicarb	TSH-888	P450
	Pyributicarb (TSH-888) is a potent activator of both CYP3A4 gene and human pregnane X receptor (hPXR).		P450
T37149	Carbamazepine 10,11-epoxide		Others
	Carbamazepine 10,11-epoxide is an active metabolite of the anticonvulsant carbamazepine.1,2It is formed from carbamazepine by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP2C8 in microsomes prepared from HepG2 cells e...		Others
T19526	Pradefovir mesylate	Pradefovir mesilate,Remofovir mesylate,Hepavir B	P450
	Pradefovir mesylate (Hepavir B) is converted to 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in human liver microsomes with Km of 60 μM.		P450
T15641	K777	APC-3316	P450 , Cysteine Protease , CCR
	K777 is a potent, orally active and irreversible inhibitor of cysteine protease. K777 is a potent CYP3A4 inhibitor (IC50= 60 nM). K777 is also a selective CCR4 antagonist featuring the potent chemotaxis inhibition. K777 ...		P450 , Cysteine Protease , CCR
T60009	YS-370		P-gp
	YS-370 is an orally active inhibitor of P-gp and shows moderate inhibition against CYP3A4. YS-370 effectively reverses multidrug resistance to paclitaxel and colchicine and exhibits stronger antitumor activity in combina...		P-gp
T6050	TAK-700	(S/R)-Orteronel,Orteronel	P450
	TAK-700 (Orteronel) (Orteronel) is a potent and highly selective human 17, 20-lyase inhibitor with IC50 of 38 nM, exhibits >1000-fold selectivity over other CYPs (e.g. 11-hydroxylase and CYP3A4). Phase 3.		P450
T9043	AS1810722		P450 , STAT
	AS1810722, a fused bicyclic pyrimidine derivative, is an orally active and potent inhibitor of STAT6, demonstrating an IC50 of 1.9 nM. It exhibits effective inhibition of CYP3A4, positioning it as a promising candidate f...		P450 , STAT
T63208	Aβ-IN-1		Gamma-secretase
	Aβ-IN-1 is a novel, potent and orally active γ-secretase modulator (GSM). Aβ-IN-1 potently reduced Aβ42 levels with an IC 50 value of 0.091 μM in cultured cells without inhibiting CYP3A4. Aβ-IN-1 shows a sustained pharma...		Gamma-secretase
T3724	Rolapitant hydrochloride	Rolapitant HCl	Neurokinin receptor
	Rolapitant (SCH619734) hydrochloride is a potent, selective, long-acting and orally active neurokinin 1 (NK1) receptor antagonist with a K i of 0.66 nM. Rolapitant hydrochloride (Rolapitant HCl) does not interact with CY...		Neurokinin receptor
T36665	Dehydro Nifedipine	BAY-b 4759
	Dehydro Nifedipine (BAY-b 4759) is the main metabolite of nifedipine in human plasma. Dehydro Nifedipine inhibits glucose uptake in PC-12 cells with an IC50 value of 130 μM. Nifedipine is a calcium channel blocker used i...
T1266	Terfenadine	(±)-Terfenadine,MDL-991	Apoptosis , Potassium Channel , 5-HT Receptor , Caspase , Na+/Ca2+ Exchanger , HER , AChR , Histamine Receptor
	Terfenadine ((±)-Terfenadine) is a prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistaminic and non-sedative effects.
T6260	AMG-208	AMG 208	P450 , c-Met/HGFR
	AMG-208 is a highly selective c-Met inhibitor with IC50 of 9 nM. Phase 1.		P450 , c-Met/HGFR
T12171	Nampt-IN-5		P450 , NAMPT
	Nampt-IN-5 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) .		P450 , NAMPT
T7699	AZD7325	AZD-7325	P450 , GABA Receptor
	AZD7325 (AZD-7325) is a GABA-Aα2,3 -selective receptor modulator.		P450 , GABA Receptor
T4567	Sulfaphenazole	Plisulfan,Raziosulfa,Depocid,Depotsulfonamide	P450 , Antibacterial
	Sulfaphenazole (Plisulfan) is an inhibitor of CYP2C9 (Ki: 0.3 μM) that demonstrates at least 100-fold selectivity over other CYP450 isoforms (Ki: 63/29 μM for CYP2C8/CYP2C18, respectively, and no activity at CYP1A1, CYP1...		P450 , Antibacterial
T0100L	Atazanavir	Zrivada,Reyataz,Latazanavir,BMS-232632	P450 , SARS-CoV , HIV Protease , P-gp
	Atazanavir (BMS-232632)(BMS-232632) is an highly effective HIV-1 protease inhibitor.		P450 , SARS-CoV , HIV Protease , P-gp
T1149	Fenofibrate	Procetofen,Lipanthyl,Lipantil	P450 , PPAR , Autophagy
	Fenofibrate (Lipanthyl) is a peroxisome proliferator receptor alpha agonist. Fenofibrate is a synthetic phenoxy-isobutyric acid derivate and prodrug with antihyperlipidemic activity.		P450 , PPAR , Autophagy
T1561	Clobetasol propionate	Dermovate,Clobetasol 17-propionate,CGP9555,Temovate,CCl 4725	Glucocorticoid Receptor , P450
	Clobetasol propionate (CGP9555) exerts its effect by binding to cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor-mediated gene expression. This results in the synthesis of certain a...		Glucocorticoid Receptor , P450
T4190	Ticlopidine	PCR 5332,Ticlid	ATPase , Adiponectin receptor
	Ticlopidine (PCR 5332) is an antiplatelet drug in the thienopyridine family which is an adenosine diphosphate (ADP) receptor inhibitor.		ATPase , Adiponectin receptor
T4488	GSK-25	GSK25	ROCK , S6 Kinase , mTOR
	GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically improved P450 profile (>2.2 uM at all isozymes tested).		ROCK , S6 Kinase , mTOR
T2305	Isavuconazole	BAL-4815,RO-0094815	P450 , Antibiotic , Antifungal
	Isavuconazole (RO-0094815)(BAL-4815; RO-0094815) is the active component of the new azole antifungal agent BAL8557 with MIC(50)s/MIC(90)s ranged from 0.002/0.004 mg/liter for C. albicans to 0.25/0.5 mg/liter for C. glabr...		P450 , Antibiotic , Antifungal
T11964	MCH-1 antagonist 1		P450
			P450
T14678	BMS-819881		P450
			P450
T22254	Alflutinib	AST2818,ASK120067	EGFR , P450
	Alflutinib (ASK120067) is an inhibitor of EGFR, and its targets including EGFR activating mutations and T790M, thus leading to tumor growth inhibition.		EGFR , P450
T25823	ML368	SR9186,ML 368,SR-9186,SR 9186,ML-368
	ML368 is a selective inhibitor of CYP3A4.
T30093	AP-24567
	AP-24567 is a CYP3A4-mediated metabolite.
T38911	Nav1.7-IN-8	Nav1.7-IN-8
	Nav1.7-IN-8 is a highly potent and selective inhibitor of NaV1.7, exhibiting greater selectivity for inhibiting NaV1.7 compared to the subtypes hNaV1.1 and hNaV1.5. Additionally, Nav1.7-IN-8 has inhibitory effects on CYP...

Compounds

Target: Proton pump, Cysteine Protease

Synonym: BBI4000,BBI 4000,BBI-4000

Target: Epigenetic Reader Domain, HIV Protease

Target: P450, ROS, Xanthine Oxidase

Clarithromycin

T1434

Synonym: A-56268

Target: P450, ribosome, MRP, Antibacterial, Antibiotic, Autophagy

TAK-715

T6150

Synonym:

Target: p38 MAPK, Casein Kinase, JNK

Esomeprazole Sodium

T2686L

Synonym: (S)-Omeprazole sodium

Target: ATPase, Proton pump

Fluticasone furoate

T21404

Synonym: Veramyst,Allermist,Avamys,Fluticasone furoate

Target: Glucocorticoid Receptor

Oxiconazole nitrate

T1290

Synonym: Ro 13-8996

Target: Others, Antibiotic, Antifection, Antifungal

Dehydroaripiprazole

T10989

Synonym: OPC-14857,DM-14857

Target: 5-HT Receptor

N-Desmethyl-Apalutamide

T12146

Synonym: N-Desmethyl Apalutamide

Target: P450, Androgen Receptor

Verapamil

T20656

Synonym: NSC 135784,NSC-135784,CP-16533-1,(±)-Verapamil

Target: P450, Calcium Channel, P-gp

Verapamil hydrochloride

T1010

Synonym: Manidon,(±)-Verapamil hydrochlorid,Verapamil HCl,Calcan hydrochloride

Target: P450, Calcium Channel, P-gp

hCYP3A4 Fluorogenic substrate 1

Synonym: BCX2600,Diacomit

Synonym: R-41400,Xolegel,(±)-Ketoconazol,Extina

Target: NADPH-oxidase, P450, Hydroxylase, Antifungal, Ras

Carbamazepine 10,11-epoxide

Synonym: Pradefovir mesilate,Remofovir mesylate,Hepavir B

Target: P450, Cysteine Protease, CCR

Synonym: (S/R)-Orteronel,Orteronel

Target: Gamma-secretase

Rolapitant hydrochloride

T3724

Synonym: Rolapitant HCl

Target: Neurokinin receptor

Synonym: (±)-Terfenadine,MDL-991

Target: Apoptosis, Potassium Channel, 5-HT Receptor, Caspase, Na+/Ca2+ Exchanger, HER, AChR, Histamine Receptor

AMG-208

T6260

Synonym: AMG 208

Target: P450, c-Met/HGFR

Target: P450, GABA Receptor

Sulfaphenazole

T4567

Synonym: Plisulfan,Raziosulfa,Depocid,Depotsulfonamide

Target: P450, Antibacterial

Atazanavir

T0100L

Synonym: Zrivada,Reyataz,Latazanavir,BMS-232632

Target: P450, SARS-CoV, HIV Protease, P-gp

Fenofibrate

T1149

Synonym: Procetofen,Lipanthyl,Lipantil

Target: P450, PPAR, Autophagy

Clobetasol propionate

T1561

Synonym: Dermovate,Clobetasol 17-propionate,CGP9555,Temovate,CCl 4725

Target: Glucocorticoid Receptor, P450

Ticlopidine

T4190

Synonym: PCR 5332,Ticlid

Target: ATPase, Adiponectin receptor

GSK-25

T4488

Synonym: GSK25

Target: ROCK, S6 Kinase, mTOR

Isavuconazole

T2305

Synonym: BAL-4815,RO-0094815

Target: P450, Antibiotic, Antifungal

Synonym: AST2818,ASK120067

Target: EGFR, P450

ML368

T25823

Synonym: SR9186,ML 368,SR-9186,SR 9186,ML-368

カタログ番号	製品名	別名	ターゲット
T10835	Cletoquine	Desethylhydroxychloroquine	Parasite , Antifection
	Cletoquine is a major active metabolite of Hydroxychloroquine. Cletoquine has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune disease treatme...		Parasite , Antifection
T3797	Isosilybin	Isosilybinin,Isosilibinin,Silymarin,Silybin B,Q-100795	P450
	Isosilybin (Isosilibinin) and Silybin might be suitable candidates to design potent PXR antagonists to prevent drug-drug interactions via CYP3A4 in cancer patients.		P450
T2S1434	Bergaptol	5-Hydroxyfuranocoumarin,4-Hydroxybergapten,5-Hydroxypsoralen	P450
	1. Bergaptol (4-Hydroxybergapten) shows very good radical scavenging activity. 2. Bergaptol is a potent inhibitor of debenzylation activity of CYP3A4 enzyme.		P450
T5594	Cedrol		P450 , Antifungal
	Cedrol is a cedrane sesquiterpenoid and a tertiary alcohol,Cedrol inhibits the cytochrome P450 (CYP) isoforms CYP2B6 and CYP3A4 (Kis = 0.9 and 3.4 μM, respectively)		P450 , Antifungal
T3401	Ginsenoside F1	20(S)-Ginsenoside F1	P450 , Endogenous Metabolite
	Ginsenoside F1 (20(S)-Ginsenoside F1) is an enzymatically modified derivative of ginsenoside Rg1, showing competitive inhibition of the activity of CYP3A4 and a weaker inhibition of the activity of CYP2D6.		P450 , Endogenous Metabolite
T11218	ε-Viniferin	epsilon-Viniferin	P450
	ε-Viniferin (epsilon-Viniferin) a dimer of resveratrol, shows the inhibitory effects of epsilon-viniferin on human CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2B6, CYP2E1, CYP3A4 and CYP4A activities.		P450
T3411	Curdione	(+)-Curdione	P450
	Curdione ((+)-Curdione) inhibits CYP3A4 activity and the production of prostaglandin E2. Curdione inhibits proliferation of MCF-7 cells by inducing apoptosis. Curdione may be a candidate for anti-inflammatory and Y chemo...		P450
TN1650	Friedelin		P450 , NOS , Caspase , Prostaglandin Receptor
	Friedelin possesses antioxidant, gastroprotective, anti-diarrhoeal, liver protective, anti-inflammatory, analgesic and antipyretic activities.		P450 , NOS , Caspase , Prostaglandin Receptor
T3417	Amentoflavone	Didemethyl-ginkgetin,Amenthoflavone,3',8''-Biapigenin	Apoptosis , P450 , Phospholipase , Reactive Oxygen Species , Opioid Receptor , COX , Antibacterial , RSV , Antifungal
	Amentoflavone (3',8''-Biapigenin), as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications. CYP3A4 and CYP2C9 are proteins used for drug metabolism in the body. Amentoflavone also is an inhib...
T2878	Ginsenoside Rd	Panaxoside Rd,Sanchinoside Rd,Gypenoside VIII	P450 , Calcium Channel , NF-κB , COX , Endogenous Metabolite
	Ginsenoside Rd (Gypenoside VIII) may have properties that inhibit or prevent the growth of tumors.
T3002	Piperine	1-Piperoylpiperidine,Bioperine	P450 , Endogenous Metabolite , P-gp , Autophagy
	Piperine (Bioperine) , a alkaloid, has been used in trials studying the treatment of multiple myeloma and deglutition disorders.		P450 , Endogenous Metabolite , P-gp , Autophagy
T3669	Curcumenol	(+)-Curcumenol	P450
	Curcumenol ((+)-Curcumenol), one of the major components of Zedoary turmeric oil, is an antibiotic drug which has anti-Y, anti-inflammation activity. Curcumenol may be safely used without inducing metabolic drug-drug int...		P450
T3735	Tetrahydrocurcumin	Sabiwhite,Tetrahydrodiferuloylmethane,HZIV 81-2,Tetrahydro Curcumin	P450 , Endogenous Metabolite , Autophagy
	Tetrahydrocurcumin (HZIV 81-2), a major metabolite of curcumin, has strong antioxidant and cardioprotective properties.		P450 , Endogenous Metabolite , Autophagy
T4A2458	Resibufogenin	Bufogenin,Recibufogenin	Others
	1. Resibufogenin (Bufogenin) is a cytotoxic steroid isolated from the Chinese drug ChanSu. 2. Resibufogenin can inhibit rectifier potassium current ( I K ) and transient potassium current ( I A ), it has pathological eff...		Others
T5S1097	Neferine	(R)-1,2-Dimethoxyaporphine,(-)-Neferine	Apoptosis , NF-κB , Autophagy
	1. Neferine ((-)-Neferine) has anti-tumor activities , Metabolic activation mediated by CYP3A4 and GSH depletion enhanced Neferine-induced cytotoxicity. 2. Neferine can be helpful to increase the efficacy of DOX and to a...		Apoptosis , NF-κB , Autophagy
T7056	Dronedarone	SR 33589	P450 , Potassium Channel , Calcium Channel , Sodium Channel , Adrenergic Receptor , AChR , Autophagy
	Dronedarone (SR 33589) is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation.
T1011	Itraconazole	R51211	P450 , Hedgehog/Smoothened , Antibiotic , Autophagy , Antifungal
	Itraconazole (R51211) is a triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.
T2946	Tanshinone IIA sulfonate sodium	Tanshinone IIA sulfonate,Sodium Tanshinone IIA sulfonate,Tanshinone IIA sodium sulfonate,sodium	CaMK , P450 , Calcium Channel
	Tanshinone IIA sulfonate sodium (Tanshinone IIA sodium sulfonate) is a water-soluble derivative of tanshinone IIA extracted from Savia miltiorrhiza; a potent negative allosteric modulator of the human purinergic receptor...		CaMK , P450 , Calcium Channel
TN1343	8-Geranyloxypsoralen		Anti-infection , P450 , BACE
	8-Geranyloxypsoralen inhibits α2-secretase (BACE1) activity in non-competitive manner, with the IC(50) values <25.0 μM, it can induce vasorelaxation on rat arterial tissues. 8-Geranyloxypsoralen possesses nematicidal act...		Anti-infection , P450 , BACE
TN3147	6',7'-Dihydroxybergamottin		P450
	6',7'-Dihydroxybergamottin(DHB), a well-known inhibitor of CYP3A4, the inhibition of CYP3A4 activity by DHB includes the inhibition of POR activity, DHB can inhibit nifedipine oxidation in a concentration-dependent manne...		P450
T82556	Dihydrocubebin	(-)-Dihydrocubebin
	Dihydrocubebin, isolated from Piper cubeba, serves as a potent and selective inhibitor of cytochrome P450 3A4 (CYP3A4) [1].
T4S1421	Praeruptorin B	Praeruptorin D	NPC1L1 , Fatty Acid Synthase
	Praeruptorin B is an inhibitor of sterol regulatory element-binding proteins (SREBPs). It can also significantly up-regulate CYP3A4 expression and activity via the PXR-mediated pathway.		NPC1L1 , Fatty Acid Synthase
TN2144	Resveratroloside		P450 , NO Synthase
	Resveratroloside has cardioprotective effect, it exhibits α±-glucosidase inhibitory activity, it also can inhibit hydroxylation of testosterone by CYP3A4.		P450 , NO Synthase
T37810	6',7'-Epoxybergamottin
	6'7'-Epoxybergamottin is a furanocoumarin found in grapefruit. It is a potent inhibitor of the cytochrome P450 (CYP) isoform CYP3A4 with an IC50 value of 0.30 ppm in a cell-free assay, 0.33 μM in HL7 human liver cells, a...
TN1843	Kushenol K		PDE , HSV
	Kushenol K is a potent and Selective Inhibitor of cGMP Phosphodiesterase 5, it also has inhibitory effects on diacylglycerol acyltransferase (DGAT). Kushenol K shows weak antiviral activity against Herpes simplex virus t...		PDE , HSV
TN1378	α-Viniferin	ALPHA-VINIFERIN	P450 , NO Synthase , Prostaglandin Receptor
	α-Viniferin known as 2-arylbenzofuran flavonoids, that are inhibitors of prostaglandin H2 synthetase. α-Viniferin has anti-Alzheimer's disease, anti-tuberculosis, anti-tumor, anti-inflammation, anti-diabetes and other ph...		P450 , NO Synthase , Prostaglandin Receptor

天然物製品

Cletoquine

T10835

Synonym: Desethylhydroxychloroquine

Target: Parasite, Antifection

Isosilybin

T3797

Synonym: Isosilybinin,Isosilibinin,Silymarin,Silybin B,Q-100795

Target: P450

Bergaptol

T2S1434

Synonym: 5-Hydroxyfuranocoumarin,4-Hydroxybergapten,5-Hydroxypsoralen

Target: P450, Antifungal

Ginsenoside F1

T3401

Synonym: 20(S)-Ginsenoside F1

Target: P450, Endogenous Metabolite

ε-Viniferin

T11218

Synonym: epsilon-Viniferin

Target: P450

Curdione

T3411

Synonym: (+)-Curdione

Target: P450, NOS, Caspase, Prostaglandin Receptor

Amentoflavone

T3417

Synonym: Didemethyl-ginkgetin,Amenthoflavone,3',8''-Biapigenin

Target: Apoptosis, P450, Phospholipase, Reactive Oxygen Species, Opioid Receptor, COX, Antibacterial, RSV, Antifungal

Ginsenoside Rd

T2878

Synonym: Panaxoside Rd,Sanchinoside Rd,Gypenoside VIII

Target: P450, Calcium Channel, NF-κB, COX, Endogenous Metabolite

Piperine

T3002

Synonym: 1-Piperoylpiperidine,Bioperine

Target: P450, Endogenous Metabolite, P-gp, Autophagy

Curcumenol

T3669

Synonym: (+)-Curcumenol

Target: P450

Tetrahydrocurcumin

T3735

Synonym: Sabiwhite,Tetrahydrodiferuloylmethane,HZIV 81-2,Tetrahydro Curcumin

Target: P450, Endogenous Metabolite, Autophagy

Resibufogenin

T4A2458

Synonym: Bufogenin,Recibufogenin

Target: Others

Neferine

T5S1097

Synonym: (R)-1,2-Dimethoxyaporphine,(-)-Neferine

Target: Apoptosis, NF-κB, Autophagy

Dronedarone

T7056

Synonym: SR 33589

Target: P450, Potassium Channel, Calcium Channel, Sodium Channel, Adrenergic Receptor, AChR, Autophagy

Itraconazole

T1011

Synonym: R51211

Target: P450, Hedgehog/Smoothened, Antibiotic, Autophagy, Antifungal

Tanshinone IIA sulfonate sodium

T2946

Synonym: Tanshinone IIA sulfonate,Sodium Tanshinone IIA sulfonate,Tanshinone IIA sodium sulfonate,sodium

Target: CaMK, P450, Calcium Channel

8-Geranyloxypsoralen

TN1343

Synonym:

Target: Anti-infection, P450, BACE

6',7'-Dihydroxybergamottin

Synonym: (-)-Dihydrocubebin

Target:

Praeruptorin B

T4S1421

Synonym: Praeruptorin D

Target: NPC1L1, Fatty Acid Synthase

Resveratroloside

TN2144

Synonym:

Target: P450, NO Synthase

6',7'-Epoxybergamottin

Synonym: ALPHA-VINIFERIN

Target: P450, NO Synthase, Prostaglandin Receptor

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-05321	CYP3A4 Protein, Human, Recombinant (His)	Human	E. coli
	CYP3A4 is an important member of the cytochrome P450 enzyme superfamily, with 33 allelic variants. Human cytochrome P450 3A4 (CYP3A4) is an important drug metabolizing enzyme involved in a number of drug-drug and food-dr...
TMPH-01259	AMFR Protein, Human, Recombinant (His)	Human	E. coli
	E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation. Component of a VC...
TMPH-01260	AMFR Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation. Component of a VC...

CYP3A4 Protein, Human, Recombinant (His)

TMPY-05321

Species: Human

Expression System: E. coli

AMFR Protein, Human, Recombinant (His)

TMPH-01259

Species: Human

Expression System: E. coli

AMFR Protein, Human, Recombinant (hFc)

TMPH-01260

Species: Human

Expression System: HEK293 Cells