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カタログ番号 | 製品名 | 別名 | ターゲット |
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T15249 | Estrogen receptor modulator 1 | Estrogen Receptor/ERR | |
Estrogen receptor modulator 1 causes regression of Tamoxifen-resistant, hormone-independent xenograft tumors. Estrogen receptor modulator 1 is an orally active and selective estrogen receptor modulator (SERM) (pIC50: 0.4... | |||
T78646 | Estrogen receptor antagonist 8 | Estrogen/progestogen Receptor | |
Estrogen receptor antagonist 8 acts as an estrogen receptor (ER) antagonist with anti-uterine activity and potential anti-tumorigenic activity and can be used to study ovarian dysfunction. | |||
T11236 | Giredestrant tartrate | Estrogen receptor antagonist 1 | Estrogen Receptor/ERR , Others |
Giredestrant tartrate (Estrogen receptor antagonist 1) is a novel, orally active, selective and effective non-steroidal estrogen receptor antagonist. Giredestrant tartrate strongly binds to ER, resulting in the failure o... | |||
T11237 | Camizestrant | Estrogen receptor antagonist 2 | Estrogen Receptor/ERR |
Camizestrant (Estrogen receptor antagonist 2) is an antagonist of the estrogen receptor and can be used in studies about ER+ HER2-advanced breast cancer[1]. | |||
T40893 | Estrogen receptor modulator 6 | ||
Estrogen receptor modulator 6 (compound 3a) is a highly specific and potent agonist of the estrogen receptor (ER) β with a remarkable affinity (K i = 0.44 nM). This compound exhibits an impressive 19-fold selectivity for... | |||
T19988 | Conjugated Estrogen sodium | Conjugated estrogens,Conest,HSDB 3076,Kestrin,Estrogens, conjugated,TAG-39 | |
Conjugated estrogens are medicine that contains a mixture of estrogen hormones. It is used to treat moderate to severe hot flashes, changes in and around the vagina, and other symptoms of menopause or low amounts of estr... | |||
T63277 | Estrogen receptor antagonist 2 | ||
Estrogen receptor antagonist 2 is a selective down-regulator of estrogen receptor. Estrogen (E2) and estrogen alpha receptor (ERα) are important drivers of breast cancer development. estrogen receptor antagonist 2 has re... | |||
T63914 | Estrogen receptor antagonist 3 | ||
Estrogen receptor antagonist 3 is a potent degradation agent of the estrogen receptor (ER). Estrogen signalling systems play an important role in the regulation of cell growth, differentiation and apoptosis, and Estrogen... | |||
T63106 | Estrogen receptor antagonist 4 | ||
Estrogen Receptor Antagonist 4 is a potent inhibitor of the estrogen receptor (ER), crucial for regulating cell growth, differentiation, and apoptosis. This compound holds promise for cancer research[1]. | |||
T79109 | Estrogen receptor modulator 8 | Estrogen Receptor/ERR | |
Estrogen Receptor Modulator 8 (compound 4) is an orally active inhibitor targeting Estrogen Receptor/ERR α with potent efficacy (IC50 = 0.437 nM in MCF-7 cells) and effectively hampers MCF-7 cell proliferation (IC50 = 0.... | |||
T62952 | Estrogen receptor antagonist 5 | ||
Estrogen receptor antagonist 5 is a potent antagonist of the Estrogen receptor. Estrogen receptor (Estrogen receptor) is a ligand-activated transcriptional regulatory protein that interacts with endogenous estrogens and ... | |||
T63582 | Estrogen receptor antagonist 1 | ||
Estrogen receptor antagonist 1 is a potent antagonist of the estrogen receptor. Estrogen receptor antagonist 1 has shown research potential in breast cancer disease. | |||
T79064 | Estrogen receptor modulator 7 | Estrogen Receptor/ERR | |
Estrogen Receptor Modulator 7 is a potent modulator of estrogen receptors, utilized in cancer research [1]. | |||
T60293 | Estrogen receptor-IN-1 | ||
Estrogen receptor-IN-1 (compound 16) is an effective estrogen receptor (ER) inhibitor with IC 50 s of 13, 5μM for ERα and Erβ, respectively [1]. | |||
T62953 | Estrogen receptor antagonist 6 | ||
Estrogen receptor antagonist 6 is a potent antagonist of the Estrogen receptor. Estrogen receptor is a ligand-activated transcriptional regulatory protein that interacts with endogenous estrogens and mediates the inducti... | |||
T61909 | Estrogen receptor antagonist 7 | ||
Estrogen Receptor Antagonist 7 (Compound 13) is a potent antagonist of estrogen receptors (ER), demonstrating antiproliferative effects against breast and ovarian cancer cells, along with anticancer and anti-uterotrophic... | |||
T82439 | Estrogen receptor modulator 10 | Estrogen Receptor/ERR | |
Compound G-5b, an estrogen receptor modulator 10, functions as an estrogen receptor (ER) antagonist (IC50=6.7 nM) and degrader (DC50=0.4 nM). It has the capability to induce apoptosis and block cells at the G1/G0 phase, ... | |||
T62311 | Estrogen receptor β antagonist 2 | ||
Estrogen receptor β antagonist 2 is a selective, potent estrogen receptor β (ERβ) antagonist that acts on Erα (IC50: 109.10 μM) and Erβ (IC50: 0.63 μM). | |||
T62764 | Estrogen receptor α antagonist 1 | ||
Estrogen receptor α antagonist 1 (compound 35) is a highly selective estrogen receptor α antagonist that acts on estrogen receptor α (IC50: 0.02 μM), estrogen receptor β (IC50. Estrogen receptor α antagonist 1 (compound ... | |||
T4388 | PHTPP | Estrogen Receptor/ERR , Estrogen/progestogen Receptor | |
PHTPP is a selective ERβ antagonist. | |||
T8984 | FLTX1 | Estrogen Receptor/ERR , Estrogen/progestogen Receptor | |
FLTX1 is a fluorescent derivative of Tamoxifen, designed to efficiently target and label intracellular Tamoxifen-binding sites (estrogen receptors) both under permeabilized and non-permeabilized conditions. Additionally,... | |||
T7904 | SR 19881 | Estrogen/progestogen Receptor | |
SR 19881 is a full agonist of ERRγ(EC50 value of 0.39 μM in a binding assay and an EC50 value of 4.7 μM in a cell-based assay). | |||
T39710 | ARV-471 | Vepdegestrant | Estrogen Receptor/ERR |
ARV-471 (Vepdegestrant) is a orally active Cereblon -based estrogen receptor (ER) PROTAC degrader. ARV-471 is developed for the research of breast cancer. | |||
T16566 | Propyl pyrazole triol | PPT | Estrogen Receptor/ERR , Estrogen/progestogen Receptor |
Propyl pyrazole triol (PPT) is a selective agonist of estrogen receptor alpha. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: ... | |||
T7644 | DPN | Diarylpropionitrile | Apoptosis , Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Autophagy |
DPN (Diarylpropionitrile) is an selective agonist of estrogen receptor β (ERβ) . | |||
T0593 | XCT790 | Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Autophagy | |
XCT790 is a potent, selective and inverse agonist of estrogen-related receptor alpha(ERRα). | |||
T7389 | G15 | Estrogen Receptor/ERR | |
G15 is a cell-permeable non-steroidal antagonist of GPER (Ki = 20 nM) | |||
T15364 | G-1 | Estrogen Receptor/ERR , GPR | |
G-1 is a nonsteroidal, high-affinity and selective GPR30 agonist (Ki: 11 nM). | |||
T14987 | CMP8 | Estrogen Receptor/ERR , Estrogen/progestogen Receptor | |
CMP8 is a selective ligand for estrogen receptor. CMP8 binds to the mutant estrogen receptor ligand binding domain (ERLBD). CMP8 has IC50 values of 29 nM , 41 nM, 1100 nM and 2200 nM for MGERα, MGRERα, hERα and hERβ, res... | |||
T3975 | AZD9496 | Estrogen Receptor/ERR , Estrogen/progestogen Receptor | |
AZD9496 is an orally available selective estrogen receptor(ERα) antagonist, with potential antineoplastic activity. | |||
T3958 | WAY-200070 | WAY 200070 | Estrogen Receptor/ERR , Estrogen/progestogen Receptor |
WAY-200070 is a specific agonist of estrogen receptor β (ERRβ, IC50: 2.3 nM). | |||
T6533 | Hexestrol | Bibenzyl,Hexanoestrol,meso-Hexestrol,Hexestrofen | Estrogen Receptor/ERR , Estrogen/progestogen Receptor |
Hexestrol (Hexanoestrol) binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively. | |||
T5531 | GSK-4716 | Estrogen Receptor/ERR | |
GSK4716 is an ERRβ/γ agonist (IC50 = 2 µM) that can activate the receptor with similar potency as the protein ligand | |||
T20625 | Prochloraz | Sporgon,Prelude | Estrogen Receptor/ERR , AhR , Androgen Receptor , Antifungal |
Prochloraz (Prelude) is a broad-spectrum contact imidazole fungicide. Prochloraz inhibits human placental microsomal aromatase in vitro (IC50 = 40 nM). Prochloraz also acts as an estrogen receptor (IC50s = 25 μM) and and... | |||
T1216 | Diethylstilbestrol | Stilbestrol,DES | Estrogen Receptor/ERR , Estrogen/progestogen Receptor |
Diethylstilbestrol (DES) is used in the treatment of menopausal and postmenopausal disorders. | |||
T8370 | GSK5182 | Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Reactive Oxygen Species | |
GSK5182 is a highly selective inverse estrogen-related receptor γ agonist (IC50 : 79 nM) | |||
T6306 | Erteberel | LY500307 | Estrogen Receptor/ERR , Estrogen/progestogen Receptor |
Erteberel (LY500307) is a potent, selective estrogen receptor β agonist with EC50 of 0.66 nM, 32-fold selectivity against estrogen receptor α. Phase 2. | |||
T5633 | H3B-5942 | Estrogen Receptor/ERR , Estrogen/progestogen Receptor | |
H3B-5942 belongs to a class of ERα antagonists referred to as selective estrogen receptor covalent antagonists (SERCA). | |||
T13443 | (R)-Equol | (+)-Equol | Estrogen/progestogen Receptor |
(R)-Equol ((+)-Equol) is an ERα and ERβ agonist with Kis of 27.4 and 15.4 nM, respectively. | |||
T13674 | Elacestrant | RAD1901 | Estrogen Receptor/ERR , Estrogen/progestogen Receptor |
Elacestrant (RAD1901) with IC50s of 48 and 870 nM for ERα and ERβ, respectively.Elacestrant is an orally available selective estrogen receptor degrader . | |||
T2567 | Etonogestrel | 3-Oxodesogestrel,3-keto-Desogestrel,Nexplanon,Implanon | Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Progesterone Receptor , Endogenous Metabolite |
Etonogestrel (Implanon) is a steroidal progestin used as hormonal contraceptives. | |||
T0168 | Estradiol (cypionate) | Depofemin,Estradiol cypionate | Estrogen Receptor/ERR , Estrogen/progestogen Receptor |
Estradiol cypionate (Depofemin), the 17 β-cyclopentylpropinate ester of estradiol, inhibits ET-1 synthesis via estrogen receptor. | |||
T0035 | Dienestrol | Restrol,Dehydrostilbestrol,Dienoestrol,Cycladiene | Estrogen Receptor/ERR , Estrogen/progestogen Receptor |
Dienestrol (Restrol) is a synthetic and nonsteroidal estrogen, which is an estrogen receptor agonist. Estrogens can increase a normal clear discharge from the vagina and make the vulva and urethra healthy. | |||
T0384 | Estradiol benzoate | Benzoestrofol,Benzhormovarine,Benovocylin | Estrogen Receptor/ERR , Estrogen/progestogen Receptor |
Estradiol benzoate (Benzhormovarine) is the synthetic benzoate ester of estradiol, a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. | |||
T7223 | Gestrinone | R 2323 | Estrogen Receptor/ERR , Estrogen/progestogen Receptor |
Gestrinone (R 2323) is a synthetic androgen receptor agonist and ER and progesterone receptor antagonist used to treat endometriosis. It inhibits leiomyoma cells with an IC50 of 43.67 μM. | |||
T13507 | 4,4'-Iminodiphenol | Leucoindophenol | Estrogen/progestogen Receptor |
4,4'-Iminodiphenol (Leucoindophenol) is an inactive estrogen receptor ligand with a diphenylamine backbone. | |||
T7556 | Fadrozole hydrochloride | CGS 16949A | Aromatase |
Fadrozole hydrochloride (CGS 16949A) is a model aromatase inhibitor that has been shown to suppress estrogen production in the ovaries of fish. | |||
T7313 | Enclomiphene citrate | Enclomifene citrate,(E)-Clomiphene citrate,trans-Clomiphene citrate | Estrogen Receptor/ERR |
Enclomiphene citrate (trans-Clomiphene citrate) is a non-steroidal estrogen receptor antagonist,with antioestrogenic property | |||
T4420 | 4-Hydroxytamoxifen | ICI 79280,(Z)-4-hydroxy Tamoxifen,trans-4-Hydroxytamoxifen | Estrogen Receptor/ERR , Estrogen/progestogen Receptor |
4-Hydroxytamoxifen (ICI 79280) is the active metabolite of Tamoxifen, an estrogen receptor modulator (SERM) with selective and oral potency. 4-Hydroxytamoxifen has antitumor activity and may be used in breast cancer rese... | |||
T8981 | WAY-169916 | WAY 169916,WAY169916 | NF-κB |
WAY-169916 is a pathway-selective inhibitor of estrogen receptor (ER). It acts by inhibiting NF-kB transcriptional activity but being devoid of conventional estrogenic activity. |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
TN1052 | Lindleyin | Estrogen Receptor/ERR , Estrogen/progestogen Receptor | |
Lindleyin is a novel phytoestrogen and might trigger many of the biological responses evoked by the physiological estrogens. | |||
T13768 | (+)-Medicarpin | Estrogen/progestogen Receptor | |
(+)-Medicarpin, a pterocarpan, is an isoflavonoid compound derived from multiple medicinal plant species such as Sophora japonica, Zollernia paraensis, Platymiscium yucatamun, Machaerium aristulatum, and Platymiscium flo... | |||
T5S0543 | Isocurcumenol | Apoptosis , Estrogen Receptor/ERR , Reductase | |
1. Isocurcumenol inhibits 5α-reductase which converts testosterone to dihydrotestosterone (DHT). | |||
T0301 | Ethisterone | 17α-Ethynyltestosterone,Pregneninolone | Estrogen Receptor/ERR , Estrogen/progestogen Receptor |
Ethisterone (17α-Ethynyltestosterone) is a progestogen hormone. | |||
T3665 | Tectoridin | Shekanin | Estrogen Receptor/ERR , Reductase |
Tectoridin (Shekanin) possesses an estrogenic and thyroid hormone-like agent by activating estrogen and thyroid hormone receptors. Tectoridin has anti-oxidant, anti-inflammatory and hypoglycemic activities; Tectoridin an... | |||
T3855 | Tracheloside | Estrogen Receptor/ERR , Phosphorylase | |
Tracheloside significantly decreases the activity of alkaline phosphatase (IC50: 0.31 μg/ml), a level of inhibition comparable to that of tamoxifen (IC50: 0.43 μg/ml). | |||
TQ0295 | Coumestrol | Estrogen Receptor/ERR | |
Coumestrol that existed in soybean products suppresses the proliferation of ES2 cells (IC50: 50 μM). It exhibits activities against neurological disorders, cancers and autoimmune diseases. | |||
T13542 | α-Zearalenol | Estrogen Receptor/ERR | |
α-Zearalenol is one of the major metabolites of Zearalenone. α-Zearalenol has structural analogy to estrogen, thus α-Zearalenol can bind to estrogen receptors (ERs). | |||
T3325 | Liquiritigenin | 4',7-Dihydroxyflavanone | Estrogen Receptor/ERR , Estrogen/progestogen Receptor |
Liquiritigenin (4',7-Dihydroxyflavanone), a flavonoid aglycone from licorice, is a highly selective estrogen receptor β (ERβ) agonist. | |||
T3913 | Saikosaponin D | Estrogen Receptor/ERR , NF-κB , Antibacterial , STAT | |
Saikosaponin D is a novel SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity. | |||
T3846 | Bavachin | Corylifolin | Estrogen Receptor/ERR , Estrogen/progestogen Receptor |
Bavachin (Corylifolin) is a phytoestrogen that activates the estrogen receptors ERα and ERβ. | |||
T4000 | (±)-Equol | Equol,(R,S)-Equol | Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Drug Metabolite |
(±)-Equol ((R,S)-Equol) is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzen by human intestinal microflora. The estrogen receptor (ER) agonist activity of the naturally occu... | |||
T1590 | Letrozole | CGS 20267 | Aromatase , Autophagy |
Letrozole (CGS 20267) is an Aromatase Inhibitor. The mechanism of action of letrozole is as an Aromatase Inhibitor. | |||
TMA1644 | Segetalin B | Estrogen Receptor/ERR | |
Segetalin B is a natural product from Vaccaria segetalis (Neck.) Garcke, has estrogen-like activity. | |||
T1009 | Estrone | Oestrone,Fluoroethyl,Aquacrine | Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Endogenous Metabolite |
Estrone (Aquacrine) is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is pr... | |||
T1571 | Estriol | NSC-12169,Oestriol | Estrogen Receptor/ERR , Estrogen/progestogen Receptor , MRP , Endogenous Metabolite |
Estriol (Oestriol) is a hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, a large amount of estriol is... | |||
T3840 | Dihydroresveratrol | 3,4',5-Trihydroxybibenzyl | Estrogen Receptor/ERR , Others |
Dihydroresveratrol (3,4',5-Trihydroxybibenzyl) is a major metabolite of resveratrol that is produced by animal-associated bacteria, including the gut microbiota. Dihydroresveratrol and dihydroresveratrol monosulfate are ... | |||
T1048 | Estradiol | E2,17β-Estradiol,17β-Oestradiol,β-Estradiol | Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Endogenous Metabolite |
Estradiol (E2) is a naturally occurring steroidal sex hormone that is essential for female fertility and maintenance of secondary sexual characteristics. Estradiol upregulates IL-6 expression through estrogen receptor be... | |||
T3385 | Gypenoside XVII | GP-17,Gynosaponin S | Estrogen Receptor/ERR , GSK-3 , Endogenous Metabolite |
Gypenoside XVII (Gynosaponin S) confers protection against Aβ25-35-induced neurotoxicity through estrogen receptor-dependent activation of PI3K/Akt pathways, activation of Nrf2/ARE/HO-1 and inactivation of GSK-3β pathway... | |||
T36857 | Estrone sulfate sodium | Estrone 3-sulfate (sodium salt),17β-Estrone 3-sulfate | Endogenous Metabolite |
Estrone sulfate sodium (17β-Estrone 3-sulfate) is an endogenous steroid and an estrogen ester that is biologically inactive. It is converted by steroid sulfatase into estrone . Estrone sulfate sodium has been investigate... | |||
T2177 | Kaempferol | Kempferol,Robigenin | Apoptosis , Estrogen Receptor/ERR , Mitophagy , Estrogen/progestogen Receptor , HIV Protease , Endogenous Metabolite , Parasite , Autophagy |
Kaempferol (Robigenin) is a natural flavonoid and an inverse agonist of ERRα and ERRγ. Kaempferol has a wide range of antitumor, anti-inflammatory, antioxidant, antibacterial and antiviral activities. | |||
T2837 | Chrysin | 5, 7-Dihydroxyflavone,NSC 407436,5,7-Dihydroxyflavone | Estrogen Receptor/ERR , Antioxidant |
Chrysin (5,7-Dihydroxyflavone) exhibits many biological activities and pharmacological effects, including antioxidant, anti-inflammatory, anticancer, and antiviral activities. | |||
T0760 | Cholesterol | Cholesterin,Cholesteryl alcohol | Estrogen Receptor/ERR , MRP , Endogenous Metabolite , ROR |
Cholesterol (cholesteryl alcohol) is a natural product that is the major sterol in mammals and an agonist of estrogen-related receptor α (ERRα). Cholesterol is widely found in the cell membranes of animals and is also us... | |||
T6491 | (-)-(S)-Equol | (−)-Equol,Equol,4',7-Dihydroxyisoflavan,4',7-Isoflavandiol | Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Endogenous Metabolite |
(-)-(S)-Equol (4',7-Dihydroxyisoflavan) is an orally bioavailable, non-steroidal estrogen naturally produced by the metabolism of the isoflavonoid daidzein by human intestinal microflora, with potential chemoprotective a... | |||
T1424 | Ethynyl estradiol | 17α-Ethynylestradiol,Ethinyl Estradiol | Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Endogenous Metabolite |
Ethynyl estradiol is a semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPTIVES... | |||
TQ0274 | 27-Hydroxycholesterol | 25(R)-27-hydroxy Cholesterol | Estrogen/progestogen Receptor , Liver X Receptor |
T0345 | Estropipate | Piperazine estrone sulfate,Pipestrone,Estrone sulfate piperazine salt | Estrogen Receptor/ERR , Estrogen/progestogen Receptor |
Estropipate (Piperazine estrone sulfate) is a natural estrogenic substance composed of estrone sulfate and piperazine. | |||
T2810 | (20S)-Protopanaxatriol | 20(S)-APPT,g-PPT | Apoptosis , Estrogen Receptor/ERR , Glucocorticoid Receptor , Estrogen/progestogen Receptor , Liver X Receptor |
(20S)-Protopanaxatriol (g-PPT)(g-PPT), a metabolite of ginsenoside, could regulate endothelial cell functions through the estrogen receptor and glucocorticoid receptor. | |||
T3806 | Kaempferide | Kaempferol 4'-O-methyl ether,Kaempferol 4'-methyl ether,4'-Methylkaempferol,4'-O-Methylkaempferol | Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Influenza Virus , Antibacterial , Autophagy |
kaempferide (4'-Methylkaempferol) inhibits the proliferation of native and estrogen receptor beta overexpressing colon cancer cells through a mechanism not mediated by ligand binding dependent estrogen receptor activatio... | |||
T1549 | Raloxifene hydrochloride | LY156758 hydrochloride,Raloxifene HCl,LY139481 hydrochloride,Keoxifene hydrochloride,LY156758 (Keoxifene) HCl | Estrogen Receptor/ERR , Others , MAO , Estrogen/progestogen Receptor , Autophagy |
Raloxifene hydrochloride (LY156758 hydrochloride) is a second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has estrogen agonist effects on bone and chol... | |||
T2882 | Genistin | Genistoside,Genistein glucoside,Genistein 7-glucoside,Genistine,Genistein 7-O-β-D-glucopyranoside | Apoptosis , Estrogen Receptor/ERR , Others |
Genistin (Genistoside) is the major isoflavonoid of soybeans and soy products.It has been reported to possess various therapeutic effects, including anti-inflammatory and anticancer activities | |||
T7299 | β-Estradiol 17-acetate | beta-estradiol 17-acetate,1,3,5(10)-Estratriene-3,17β-diol 17-acetate | Estrogen Receptor/ERR , Others |
β-Estradiol 17-acetate (1,3,5(10)-Estratriene-3,17β-diol 17-acetate) is a metabolite of estradiol. | |||
TN1719 | Gymnestrogenin | Liver X Receptor | |
Gymnestrogenin has a dual LXRα±/α2 antagonistic profile. | |||
T13481 | 2-Methoxyestrone | Endogenous Metabolite | |
2-Methoxyestrone is a methoxylated catechol estrogen and metabolite of estrone (pKa: 10.81). | |||
T36857L | Premarin | Estrone 3-sulfate,Estrone sulfate | Estrogen Receptor/ERR |
Premarin (Estrone 3-sulfate) is an an estrogen sulfate with neuroprotective actions during traumatic brain injury. | |||
T15248 | Estetrol | Donesta | Estrogen Receptor/ERR , Endogenous Metabolite |
Estetrol(Donesta) is an orally available, selective modulator of the estrogen receptor, a naturally occurring estrogen synthesized by the human fetal liver during pregnancy.Estetrol has effects on the endometrium or cent... | |||
TN2197 | Secoisolariciresinol | TNF | |
Secoisolariciresinol is an enterolignan precursor, it has antioxidant, and estrogen-like activities, it can significantly suppress triglyceride (TG) accumulation in 3T3-L1 adipocytes. | |||
T73772 | Estrone sulfate potassium | Endogenous Metabolite | |
Estrone sulfate potassium is an estrogen ester and conjugate, a natural endogenous steroid. | |||
T3378 | Alpha-Estradiol | Alfatradiol,17α-Estradiol,Epiestrol,Epiestradiol | Estrogen/progestogen Receptor , Reductase , Endogenous Metabolite |
Alpha-Estradiol (Epiestradiol) is an estrogen that inhibits 5alpha-reductase and has potential in the study of androgenetic alopecia. | |||
TN1148 | Isopsoralenoside | Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Antibacterial | |
Isopsoralenoside shows estrogen-like, osteoblastic proliferation accelerating, antitumor, and antibacterial effects. | |||
T16338 | Norgestimate metabolite Norelgestromin | 17-Deacetyl norgestimate,17-Deacylnorgestimate | Drug Metabolite |
Norgestimate metabolite Norelgestromin (17-Deacylnorgestimate) is one of the active metabolites of norgestimate.It is a steroidal progestin used in contraceptive patches, where it is combined with the estrogen ethinyl es... | |||
T16525 | PhIP | Others | |
PhIP is a heterocyclic aromatic amine (HAA) from cooked meat. It belongs to pyridine heterocyclic amine and is a 2B carcinogen with estrogen activity. PhIP forms adducts with DNA that promote cancer. | |||
TN1008 | Psoralenoside | CaMK , Calcium Channel , Histamine Receptor | |
Psoralenoside is a natural product isolated from the fruits of Psoralea corylifolia, shows estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity. | |||
TN1702 | Glycycoumarin | P450 , JNK , AMPK , Autophagy | |
Glycycoumarin is an estrogen agonist, it shows moderate inhibitory effects against CYP1A2 and CYP2B6. | |||
T2777 | Ginsenoside Rg1 | Sanchinoside C1,Panaxoside Rg1,Sanchinoside Rg1,Panaxoside A,Ginsenoside A2 | Apoptosis , Beta Amyloid , NF-κB |
Ginsenoside Rg1 (Panaxoside Rg1) is a class of steroid glycosides, and triterpene saponins found exclusively in the plant genus Panax (ginseng). It improves spatial learning and increase hippocampal synaptophysin level i... | |||
TN1918 | Medicarpin | Apoptosis , BCL , ROS , JNK | |
Medicarpin, a legume phytoalexin, acts as an estrogen receptor (ER) agonist, can stimulate osteoblast differentiation likely via ERα², promote achievement of peak bone mass, and is devoid of uterine estrogenicity; in add... | |||
T3717 | Hinokitiol | 4-Isopropyltropolone,β-thujaplicin | DNA Methyltransferase , Virus Protease , Estrogen/progestogen Receptor , Nrf2 |
Hinokitiol (4-Isopropyltropolone) can inhibit ultraviolet B-induced apoptosis in keratinocytes and strongly suggest that the inhibitory mechanism is due to the antioxidant activity of metallothionein induced by the agent... | |||
T64744 | Ovalbumins | Endogenous Metabolite | |
Ovalbumins is the main protein found in egg whites. Ovalbumins have various biological activities such as antibacterial, anticancer, antihypertensive, antioxidant and immunomodulatory activities. Ovalbumins are the most ... | |||
T3923 | Calycosin | Cyclosin,3'-Hydroxyformononetin | Apoptosis , Tyrosinase |
Calycosin (Cyclosin) acts as a selective estrogen receptor modulator. Calycosin induces apoptosis in human ovarian cancer SKOV3 cells by activating caspases and Bcl-2 family proteins. Calycosin suppresses breast cancer c... | |||
T1660 | Silibinin | Silibinin A,Silybin,Silymarin I | Reactive Oxygen Species , Autophagy |
Silibinin (Silybin) is the major active constituent of silymarin, a standardized extract of the milk thistle seeds, containing a mixture of flavonolignans consisting of silibinin, isosilibinin, silicristin, silidianin an... | |||
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カタログ番号 | 製品名 | Species | Expression System |
---|---|---|---|
TMPJ-00762 | ER alpha Protein, Human, Recombinant (His) | Human | E. coli |
Estrogen Receptor is a major ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. Estrogen Receptor is composed of several domains important for hormone binding, DNA binding, and a... | |||
TMPY-03496 | EBAG9 Protein, Human, Recombinant (His) | Human | E. coli |
RCAS1, also known as EBAG9, is a tumor-associated antigen that is expressed at high frequency in a variety of cancers. RCAS1 gene was identified as an estrogen-responsive gene. Regulation of transcription by estrogen ... | |||
TMPH-00956 | Aromatase/CYP19A1 Protein, Human, Recombinant (His) | Human | E. coli |
Aromatase/CYP19A1 Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPY-04396 | C-ABL/ABL1 Protein, Human, Recombinant (GST) | Human | Baculovirus Insect Cells |
c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cy... | |||
TMPJ-01192 | ELAPOR1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Endosome/lysosome-associated apoptosis and autophagy regulator (ELAPOR1), also known as EIG121 protein, is a type I transmembrane protein induced by estrogen. The estrogen-induced gene 121 (EIG121) has been associated wi... | |||
TMPY-01660 | SULT1E1 Protein, Human, Recombinant (His) | Human | E. coli |
Estrogen sulfotransferase, also known as Sulfotransferase, estrogen-preferring, Sulfotransferase 1E1, SULT1E1 and ST1E1, is a cytoplasm enzyme that belongs to the sulfotransferase 1 family. Sulfotransferase enzymes catal... | |||
TMPH-01305 | ER beta Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) |
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.; Lacks ... | |||
TMPH-01304 | ER beta Protein, Human, Recombinant (E. coli, His) | Human | E. coli |
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.; Lacks ... | |||
TMPH-00498 | Prorelaxin Protein, Canine, Recombinant (His) | Canine | E. coli |
Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. Prorelaxin Protein, Canine, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. Th... | |||
TMPH-02851 | PDIA2 Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli |
Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded protei... | |||
TMPH-01302 | HSD17B1 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Favors the reduction of estrogens and androgens. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2). Also has 20-alpha-HSD activity. Uses preferentially NADH. HSD17B1 Protein, Human, Recombinant (His ... | |||
TMPY-04780 | VMO1 Protein, Human, Recombinant | Human | HEK293 Cells |
Vitelline membrane outer layer protein 1 (VMO1), a basic protein present in the outer layer of the vitelline membrane of eggs, plays essential roles in separating the yolk from the egg white and preventing infection from... | |||
TMPJ-00705 | BCAS2 Protein, Human, Recombinant (His, T7) | Human | E. coli |
Breast Carcinoma-Amplified Sequence 2 (BCAS2) is a member of the SPF27 family. BCAS2 is a nuclear protein and widely expressed in many rtissues. BCAS2 is identified as being overexpressed in various breast cancer cell li... | |||
TMPY-00375 | VMO1 Protein, Human, Recombinant (mFc) | Human | HEK293 Cells |
Vitelline membrane outer layer protein 1 (VMO1), a basic protein present in the outer layer of the vitelline membrane of eggs, plays essential roles in separating the yolk from the egg white and preventing infection from... | |||
TMPY-06226 | SLC39A6/LIV-1 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
Along with the SLC30 family, SLC39 family members regulate zinc movement in cells. SLC39 metal ion transporters accumulate zinc into the cytosol. SLC39A6, also known as LIV-1, belongs to a new subfamily of Zrt, Irt-like ... | |||
TMPY-01826 | Relaxin 1/RLN1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Relaxin-1, also known as Prorelaxin H1 and RLN1, is a secreted protein that belongs to the insulin family. It is a peptide hormone that was first described in 1926 by Frederick Hisaw. Since its discovery as a reproductiv... | |||
TMPJ-00253 | OPG Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Osteoprotegerin (OPG, Tnfrsf11b) is a secreted protein that regulates bone density. OPG is widely expressed and constitutively released as a homodimer by mesenchymal stem cells, fibroblasts and endothelial cells. Regulat... | |||
TMPJ-00056 | AG-2 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Anterior Gradient 2 (AGR2) is an 18-21 kDa member of the PDI family of enzymes. AGR2 is widely expressed in secretory cells, such as small intestine goblet, prostate epithelium, enteroendocrine cells, and multiple carcin... | |||
TMPY-02843 | GPX7 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
GPX7 gene contains 3 distinct gt-ag introns. Transcription produces 4 different mRNAs, 3 alternatively spliced variants, and 1 unspliced form. There are 5 validated alternative polyadenylation sites. The mRNAs appear to ... | |||
TMPY-04828 | TFF3 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Trefoil factor family (TFF) peptides are involved in the maintenance of epithelial integrity and epithelial restitution. Trefoil factor-3 (TFF3) is an estrogen-regulated gene associated with prognosis in different types ... | |||
TMPY-04422 | Casein Kinase 1 gamma 2 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
Casein kinase I gamma 2 isoform (CSNK1G2), a member of the large casein kinase I (CKI) subfamily, protein kinase superfamily. It may affect the development of brain, and associate with vesicular trafficking and neurotran... | |||
TMPY-02214 | OTUB1 Protein, Human, Recombinant (His) | Human | E. coli |
Ubiquitin thioesterase OTUB1, also known as Deubiquitinating enzyme OTUB1, OTU domain-containing ubiquitin aldehyde-binding protein 1, Otubain-1, Ubiquitin-specific-processing protease OTUB1, OTUB1 and OTB1, is a cytopla... |
カタログ番号 | 製品名 | ||
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L2191 | Anti-Breast Cancer Compound Library | 1939 compounds | |
A unique collection of 1939 compounds with anti-breast cancer therapeutic activity or targeting breast cancer’s major signaling pathways, can be used for anti-breast cancer drug discovery and mechanism study; |