検索結果

Search Results for " antitumour "

ターゲット

阻害剤

天然化合物

カタログ番号	製品名	別名	ターゲット
T5521	Bropirimine	U-54461	TLR
	Bropirimine (U-54461) (U-54461) is a biological response modifier that is thought to act through the induction of lymphokines.		TLR
T4451	Estramustine phosphate sodium	Ro 21-8837/001,Estramustine phosphate disodium	Apoptosis , Microtubule Associated
	Estramustine phosphate sodium (Ro 21-8837/001) is an antimicrotubule chemotherapy agent; arrests prostate cancer cells in the G2/M phase of the cell cycle.		Apoptosis , Microtubule Associated
T27603	INCB3619	INCB-3619,INCB 3619	Immunology/Inflammation related
	INCB3619 is a selective and potent inhibitor of ADAM with antitumour effects, inhibiting ADAM10, ADAM17, MMP12 and MMP15.		Immunology/Inflammation related
T77732L	HFY-4A HCL (2094810-82-7 Free base)
	HFY-4A HCL is a novel HDAC inhibitor.HFY-4A HCL has antitumour activity and has shown antiproliferative activity in breast cancer cells.
T67884	β-catenin modulator IIa-661		Wnt/beta-catenin
	β-catenin modulator IIa-661 is a small molecule inhibitor of the Wnt pathway with antitumour activity.		Wnt/beta-catenin
TNU0031	5-Hydroxyuridine	OHUrd	Nucleoside Antimetabolite/Analog
	5-Hydroxyuridine (OHUrd) is a purine nucleoside analogue with potential antitumour activity, showing cytotoxicity against human colon adenocarcinoma cell lines.		Nucleoside Antimetabolite/Analog
T69644	DUN73423	RET-IN-21	c-RET
	DUN73423 (RET-IN-21) is a potent tyrosine kinase (RET) inhibitor with antitumour activity for the study of cancer.		c-RET
T61428	4-PQBH		Others
	4-PQBH is a potent Nur77-binding agent with antitumour activity.4-PQBH inhibits xenograft tumours through Nur77-mediated endoplasmic stress and autophagy by broadly inducing cysteoaspartase-independent cytoplasmic vacuol...		Others
T12365	PARP/PI3K-IN-1		PARP , PI3K
	PARP/PI3K-IN-1 is a novel dual poly (ADP-ribose) polymerase (PARP) and phosphatidylinositol 3-kinase (PI3K) dual inhibitor with anticancer, antitumour and antiproliferative activities for the study of breast, pancreatic ...		PARP , PI3K
T5335	S-Gboxin		Others
	S-Gboxin is an active analogue of Gboxin with potent antitumour activity. S-Gboxin inhibits the growth of mouse and human glioblastoma (GBM, IC50: 470 nM).		Others
T5448	Clanfenur		Others
	Clanfenur belongs to a new group of substituted benzoylphenylureas. The drug shows both in vitro and in vivo antitumour activity.		Others
T15373	Gboxin		ATPase , Mitochondrial Metabolism
	Gboxin is an inhibitor of oxidative phosphorylation that targets glioblastoma,inhibits the activity of F0F1 ATP synthase, with antitumour activity.		ATPase , Mitochondrial Metabolism
T71553	Ainsliadimer A
	Ainsliadimer A, a sesquiterpene lactone dimer from Ainsliaea macrocephala, has antitumour activity and induces cell death in various cancer cells.
T29857	Alethine	β-Alethine	TNF
	Alethine (β-Alethine) is a small molecule compound with antitumour activity and is used to treat tumours and infections. The alethine-induced up-regulation of TNFα increases the cytotoxicity of T cells.		TNF
T29541	AC265347	AC-265347	CaSR
	AC265347 is a potent calcium-sensitive receptor (CaSR) agonist and ago-PAM orthosteric modulator with antitumour activity that inhibits neuroblastoma tumour growth by inducing differentiation.AC265347 can be used to stud...		CaSR
T11745	KB SRC 4		Src
	KB SRC 4 is a selective and potent c-Src inhibitor with antitumour activity that inhibits the growth of cancer cells.		Src
T28284	P22074	P-22074	DUB
	P22074 is a USP7 inhibitor. It is not an active antagonist like its halogenated related compounds. p22074 has antitumour activity.		DUB
T69691	Pocenbrodib	FT-7051,P-300	Epigenetic Reader Domain
	Pocenbrodib (FT-7051) is a potent inhibitor of the bromodomain of the CBP/p300 family with potential antitumour activity and is palatable for cancer research.		Epigenetic Reader Domain
T77519	FC-116	FC116	Apoptosis , Microtubule Associated
	FC-116 is a potent Tubulin inhibitor with antitumour activity and inhibits tumour growth in mice. FC-116 induces apoptosis in colorectal cancer (CRC) cells and promotes protein degradation.		Apoptosis , Microtubule Associated
T26897	BRD2492		HDAC
	BRD2492 is a selective and potent dual inhibitor of HDAC1 and HDAC2 with potential anticancer, antitumour and antiproliferative activities, inhibiting HDAC1/2, HDAC3 and HDAC6.BRD2492 inhibits the growth of breast cancer...		HDAC
T77810	XPW1		CDK
	XPW1 is a new potent and selective CDK9 inhibitor with antitumour activity that transcriptionally inhibits the DNA repair process in ccRCC cells.XPW1 can be used to study clear cell renal cell carcinoma.		CDK
T16697	Pyronaridine tetraphosphate		Topoisomerase
	Pyronaridine tetraphosphate is an orally active, mannitol-containing inhibitor of DNA topoisomerase 2 and erythrocyte cytokine with antimalarial and antitumour activity.Pyronaridine tetraphosphate treats P. falciparum an...		Topoisomerase
T36646	Trastuzumab deruxtecan	DS-8201a,VRN-101099,DS 8201,T-DXd	Others
	Trastuzumab deruxtecan (T-DXd) is an antibody-activated molecule coupling (ADC) with anticancer and antitumour activity.Trastuzumab deruxtecan has been shown to have an ameliorative effect in HER2-positive breast and gas...		Others
T63732	EGFR-IN-3		Apoptosis , EGFR
	EGFR-IN-3 is an EGFR inhibitor with potential antitumour activity.EGFR-IN-3 inhibits EGFRwt-TK and induces apoptosis (cell death), which can cause cells to block in the G2/M phase.		Apoptosis , EGFR
T67970	GPX-100	13-deoxydoxorubicin	Others
	GPX-100 (13-deoxydoxorubicin) is an analogue of the anthracycline antitumour antibiotic doxorubicin. GPX-100 inserts into DNA and interacts with topoisomerase II to inhibit DNA replication and repair as well as RNA and p...		Others
T77759	GPX4-IN-6		GPX
	GPX4-IN-6 is a small molecule covalent GPX4 inhibitor (IC50: 0.12 μM) with antitumour activity.GPX4-IN-6 induces iron death and is used for the treatment= and prevention of triple negative breast cancer (TNBC).		GPX
T77755	GPX4-IN-5		GPX
	GPX4-IN-5 is a small molecule covalent GPX4 inhibitor (IC50: 0.12 μM) with antitumour activity.GPX4-IN-5 induces iron death and can be used for the prevention and treatment of triple-negative breast cancer (TNBC).		GPX
T72084	(R)-BI-2852		Ras
	(R)-BI-2852 can be used as (R)-5-isoindolin-1-one is used as an inhibitor of the RAS family of proteins and as a compound for the treatment and prevention of tumours. (R)-BI-2852 has Antiproliferative and antitumour agen...		Ras
T77745	N6F11		GPX
	N6F11 is a novel, selective and potent inducer of iron death with anticancer and antitumour activity that promotes GPX4 degradation by binding to TRIM25 in cancer cells.N6F11 can be used to study pancreatic cancer.		GPX
T15771	Lobaplatin	D-19466	DNA Alkylation
	Lobaplatin (D-19466) (D-19466) is a diastereometric mixture of platinum(II) complexe. Lobaplatin (D-19466) is a third-generation platinum anti-neoplastic agent which shows activity for a variety of tumour types and is a ...		DNA Alkylation
T72553	ARTD10/PARP10-IN-1		PARP
	ARTD10/PARP10-IN-1 is a potent PARP inhibitor of the mono-ADP ribosyltransferases ARTD7/PARP15, ARTD8/PARP14, ARTD10/PARP10 and poly ADP-ribose polymerase-1 (ARTD1/PARP1), with potential anticancer and antitumour activit...		PARP
T67934	MRT-2359		Others
	MRT-2359 is a potent and orally available GSPT1 reducer with antitumour activity.MRT-2359 inhibits the growth of drug-resistant non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) cells.MRT-2359 exhibits...		Others
T61338	MS023 dihydrochloride	MS023 2HCl	Histone Methyltransferase
	MS023 dihydrochloride (MS023 2HCl) is a selective, cytosolic and highly potent inhibitor of human type I protein arginine methyltransferases (PRMTs) with antitumour activity, inhibits PRMT1, PRMT3, PRMT4, PRMT6, and PRMT...		Histone Methyltransferase
T60446	LCS3		Apoptosis , Glutathione reductase
	LCS3 is a reversible and non-competitive synergistic inhibitor of glutathione disulfide reductase (GSR) and thioredoxin reductase 1 (TXNRD1) with IC50s of 3.3 μM and 3.8 μM, respectively. LCS3 has antitumour activity, in...		Apoptosis , Glutathione reductase
T72505	CTP Synthetase-IN-1		Others
	CTP Synthetase-IN-1 is an orally active and potent cytidine 5'-triphosphate synthetase (CTPS) inhibitor with potential antitumour activity, shows anti-inflammatory activity in animal models of inflammation, inhibits huma...		Others
T36082	Cysmethynil		Autophagy , Ras
	Cysmethynil is an indole-based time-dependent inhibitor of Icmt with antitumour activity and inhibitory effects on RAS membrane-binding and EGF signalling.Cysmethynil induces cell cycle arrest in G1 phase and induces cel...		Autophagy , Ras
T4374	Edoxudine	Aedurid,EUDR,Epoxudine	Antiviral , Antibacterial
	Edoxudine (Epoxudine), an antiviral drug, is an analogue of thymidine and shows effectiveness against the herpes simplex virus. Edoxudine is used as a 5-fluorouracil (FU) modulator. Edoxudine may be used to enhance the t...		Antiviral , Antibacterial
T63746	Vamotinib	PF-114	Apoptosis , Tyrosine Kinases , Bcr-Abl
	Vamotinib (PF-114) is an orally active and specific tyrosine kinase inhibitor with antiproliferative and antitumour activity.Vamotinib inhibits the phosphorylation of BCR/ABL and BCR/ABL-T315I, which promotes apoptosis. ...		Apoptosis , Tyrosine Kinases , Bcr-Abl
T62083	Camonsertib	ATR inhibitor 4,RP-3500	ATM/ATR
	Camonsertib (RP-3500) is a selective, orally active ATR kinase inhibitor (ATRi) with an IC50: 1.00 nM in biochemical assays and exhibits potent antitumour effects. Camonsertib is 30 times more selective for ATR than mTOR...		ATM/ATR
T14680	BMS-906024	Osugacestat,AL-101,BM-0018	Gamma-secretase
	BMS-906024 (Osugacestat) is an orally available and selective inhibitor of γ-secretase, a small molecule Notch inhibitor.BMS-906024 has broad-spectrum antitumour activity against a variety of human cancer xenografts.BMS-...		Gamma-secretase
T63049	CHD1Li 6.11		Others
	CHD1Li 6.11 is a potent inhibitor of oncogenic CHD1L, acting on the cat-CHD1L recombinant protein (IC50: 3.3 μM). CHD1Li 6.11 is an orally active antitumour agent that significantly reduces the tumour volume of CRC xenog...		Others
T79745	IDH2R140Q-IN-2		Dehydrogenase
	IDH2R140Q-IN-2 is an orally active and potent IDH2R140Q inhibitor with an IC50 of 29 nM.IDH2R140Q-IN-2 possesses potential antitumour activity, reducing D2HG production in TF-1 cell lines carrying the IDH2R140Q mutation ...		Dehydrogenase
T10870L	CP-547632		VEGFR , FGFR , PDGFR , BTK
			VEGFR , FGFR , PDGFR , BTK
T62245	Basroparib
	Basroparib is an inhibitor of ribose polymerase (PARP) and has shown antitumour effects.
T62493	QW30
	QW30 has a significant antitumour effect (IC50: 0.33 μM).
T62650	Culmerciclib
	Culmerciclib is a cell cycle protein-dependent kinase (CDK) inhibitor that exhibits antitumour effects.
T63084	Guraxetan
	Guraxetan can be used in the synthesis of the antitumour drug Lutetium (177Lu) zadavotide Guraxetan.
T64236	AS 1411
	AS1411 is a nucleic acid aptamer that targets nucleophosmin and exhibits antitumour effects.
T64039	KRAS G12C inhibitor 49
	KRAS G12C inhibitor 49 is an orally active KRAS G12C inhibitor that exhibits antitumour effects.
T63100	EP4 receptor antagonist 2
	EP4 receptor antagonist 2 (compound 2-13) is a potent agonist of the EP4 receptor (IC50: 7.8 nM) and has antitumour effects.

Compounds

Estramustine phosphate sodium

T4451

Synonym: Ro 21-8837/001,Estramustine phosphate disodium

Target: Apoptosis, Microtubule Associated

INCB3619

T27603

Synonym: INCB-3619,INCB 3619

Target: Immunology/Inflammation related

HFY-4A HCL (2094810-82-7 Free base)

T77732L

Synonym:

Target:

β-catenin modulator IIa-661

T67884

Synonym:

Target: Wnt/beta-catenin

5-Hydroxyuridine

TNU0031

Synonym: OHUrd

Target: Nucleoside Antimetabolite/Analog

Target: ATPase, Mitochondrial Metabolism

Synonym: FT-7051,P-300

Target: Epigenetic Reader Domain

FC-116

T77519

Synonym: FC116

Target: Apoptosis, Microtubule Associated

Pyronaridine tetraphosphate

T16697

Synonym:

Target: Topoisomerase

Trastuzumab deruxtecan

T36646

Synonym: DS-8201a,VRN-101099,DS 8201,T-DXd

Target: Apoptosis, EGFR

GPX-100

T67970

Synonym: 13-deoxydoxorubicin

Target: DNA Alkylation

MS023 dihydrochloride

T61338

Synonym: MS023 2HCl

Target: Histone Methyltransferase

LCS3

T60446

Synonym:

Target: Apoptosis, Glutathione reductase

Target: Autophagy, Ras

Edoxudine

T4374

Synonym: Aedurid,EUDR,Epoxudine

Target: Antiviral, Antibacterial

Vamotinib

T63746

Synonym: PF-114

Target: Apoptosis, Tyrosine Kinases, Bcr-Abl

Camonsertib

T62083

Synonym: ATR inhibitor 4,RP-3500

Target: ATM/ATR

BMS-906024

T14680

Synonym: Osugacestat,AL-101,BM-0018

Target: Gamma-secretase

Target: Dehydrogenase

CP-547632

T10870L

Synonym:

Target: VEGFR, FGFR, PDGFR, BTK

KRAS G12C inhibitor 49

T64039

Synonym:

Target:

EP4 receptor antagonist 2

T63100

Synonym:

Target:

カタログ番号	製品名	別名	ターゲット
T1181	Gefitinib	ZD1839	EGFR , Tyrosine Kinases , Autophagy
	Gefitinib (ZD1839) is an EGFR first-generation inhibitor with oral activity that inhibits the EGFR 19 Del and L858R mutations. Gefitinib has antitumor activity and is used for the treatment of EGFR-mutated non-small-cell...		EGFR , Tyrosine Kinases , Autophagy
Fr12290	4-Methoxycoumarine		Others
	4-Methoxycoumarine has antitumour effects.		Others
TN1757	Hypophyllanthin		Potassium Channel , Calcium Channel , P-gp
	Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice.		Potassium Channel , Calcium Channel , P-gp
T7468	(-)-α-Terpineol	α-Terpineol	Others
	(-)-α-Terpineol has antitumour, anti-inflammatory, and antimicrobial activities, it inhibits the growth of tumour cells through a mechanism that involves inhibition of the NF-kappaB pathway		Others
TMA2253	Triumbelletin		Others
	Triumbelletin is a tricoumarin rhamnopyranoside obtained from Wikstroemia indica with antitumour activity for the study of tumours.		Others
T5S1952	9-Methoxycamptothecin		Apoptosis , Topoisomerase
	9-Methoxycamptothecin (MCPT) has antitumour activities through topoisomerase inhibition.		Apoptosis , Topoisomerase
T3S1858	Lutein	Vegetable Lutein,Xanthophyll,Bo-Xan,Xantofyl	Antibacterial
	1. Lutein (Xantofyl) has antitumour action. 2. Lutein has antimutagenic action. 3. Lutein has a wide range of antimicrobial action. 4. Lutein is potentially useful for treating macular degeneration.		Antibacterial
T5S2083	Puerarin 6''-O-Xyloside		Apoptosis , Caspase
	Puerarin 6''-O-xyloside possesses significant anti-osteoporotic activity on ovariectomy mice, it has significant antitumour activities, the mechanisms are related to increased levels of caspase-3, caspase-7, caspase-9 an...		Apoptosis , Caspase
T36914	2-Hydroxyanthraquinone		Others
	2-Hydroxyanthraquinone is an anthraquinone that has been found inSpermacoce latifoliaand has antibacterial and estrogenic activities.1,2It is active againstB. subtilisandB. cereus(MICs = 1.9 and 62.5 μg/ml, respectively)...		Others
TN1664	Ganoderic acid H		NF-κB , DNA/RNA Synthesis , CDK
	Ganoderic acid H is a potent antitumour agent, it mediates its biological effects through the inhibition of transcription factors AP-1 and NF-kappaB, resulting in the down-regulation of expression of Cdk4.		NF-κB , DNA/RNA Synthesis , CDK
T3864	Erianin		BCL , Antibacterial
	Erianin is a nature product extracted from Dendrobium chrysotoxum, has notable antitumour activity , can cause extensive tumour necrosis, growth delay. Erianin has antiangiogenic action by inhibiting endothelial metaboli...		BCL , Antibacterial
T4001	Euxanthone	1,7-Dihydroxyxanthone	Autophagy
	Euxanthone (1,7-Dihydroxyxanthone), an xanthone derivative extracted from the roots of Polygala tenuifolia Willd, has antitumour, neuroprotective and vasorelaxant activities, and attenuates Aβ1-42-induced oxidative stres...		Autophagy
T16165	Myriocin	ISP-I,Thermozymocidin	HCV Protease , Antifungal
	Myriocin (Thermozymocidin), a metabolite derived from Myriococcum albomyces, is a serine-palmitoyltransferase (SPT) inhibitor with potential antitumour, anticancer, and antiparasitic activities.Myriocin inhibits tumour g...		HCV Protease , Antifungal
T4672	Brevilin A		Apoptosis , Anti-infection , JAK , STAT , Autophagy
	Brevilin A is a sesquiterpene lactone isolated from Centipeda minima, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells with anti-tumor activity. Brevilin A is a selective inhibitor of JAK-STAT si...		Apoptosis , Anti-infection , JAK , STAT , Autophagy
T3795	Corilagin		Apoptosis , TLR , Reverse Transcriptase , Antibacterial , Autophagy
	Corilagin has anti-inflammatory activity. Corilagin has a significant antitumour potential and lower toxicity in normal cells in vitro.Corilagin can enhance the cytotoxicity of both cisplatin and doxorubicin on the Hep3B...
TN6043	Cyclo(D-Leu-L-Pro)
	Cyclo(D-Leu-L-Pro) shows antitumour and antifungal activities.
TN6569	Cis-Moschamine
	cis-Moschamine exerts antitumour effects on HeLa, MCF7 and A431 cells.
T28920	TAN-420C	TAN 420C,TAN420C,Dihydroherbimycin C
	TAN-420C is an antibiotic isolated from Streptomyces hygroscopicus with antitumour activity.
TN2002	Obovatol		BCL , Caspase , JAK
	Obovatol has antioxidant, neuroprotective, antiinflammatory, antithrombotic and antitumour effects, it is a potent NF-κB inhibitors for Alzheimer's disease treatment.		BCL , Caspase , JAK
TN5021	Sikokianin C
	Sikokianin C is a biflavonoid isolated from Wikstroemia sikokiana.Sikokianin C is a selective cystathionine β-synthase inhibitor with antitumour activity for the treatment of human colon cancer.
TN2328	Zeylenone		Apoptosis , ERK , MAPK , Akt , PI3K , mTOR
	Zeylenone, a cyclohexene oxide from Uvaria grandiflora, has antitumour and antiproliferative activity, inhibiting cervical cancer cell proliferation and inducing apoptosis through the PI3K/AKT/mTOR and MAPK/ERK signallin...		Apoptosis , ERK , MAPK , Akt , PI3K , mTOR
TN2344	Swainsonine	Tridolgosir	Apoptosis , Others , Antibiotic
	Swainsonine (Tridolgosir) is an alkaloid isolated from Astragalus membranaceus and is a potent and reversible inhibitor of alpha-mannosidase. swainsonine has antitumour activity and induces apoptosis and cell cycle arres...		Apoptosis , Others , Antibiotic