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Search Results for " transduction "

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102

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天然化合物

126

リコンビナントタンパク質

ライブラリー

カタログ番号	製品名	別名	ターゲット
T21493	Cyclosporin H		Others
	Cyclosporin H (CsH), a specific inhibitor of FPR1, inhibited lung inflammation in the ALI models. CsH significantly attenuated MTDs or NFP-induced inflammatory lung injury and activation of MAPK and AKT pathways. Cyclosp...		Others
T21543	AP 18		TRP/TRPV Channel
			TRP/TRPV Channel
T7123	AMG-47a		VEGFR , p38 MAPK , JAK , Src
	AMG-47a is a potent inhibitor of Lck and T cell proliferation. AMG-47a could promote the degradation of the KRAS oncoprotein. AMG-47a selectively reduced the levels of EGFP-KRASG12V protein but did not affect EGFP protei...		VEGFR , p38 MAPK , JAK , Src
T0097	MRT67307	MRT67307 HCl	IκB/IKK , Autophagy
	Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy. MRT67307 prevents the phosphorylation of IRF3 and the production of IFN-β and increases toll-like receptor-induced IL-10 and IL-1ra secretion in macrophage...		IκB/IKK , Autophagy
T3569	SU5214	SU 5214	VEGFR , Tyrosinase
	SU5214 is a modulator of tyrosine kinase signal transduction.		VEGFR , Tyrosinase
T9292	ALE-0540	ALE0540	Others , Trk receptor
	ALE-0540 is a nonpeptidic heterocyclic molecule that inhibits the binding of NGF to p75 and TrkA, as well as signal transduction and biological responses mediated by TrkA receptors.		Others , Trk receptor
T2648	Pimecrolimus	SDZ-ASM 981,ASM 981	Others
	Pimecrolimus (SDZ-ASM 981), a calcineurin inhibitor immunosuppressant, binds to the receptor macrophilin-12 (FKBP-12) forming a complex that blocks the calcium-dependent signal transduction cascade mediated by calcineuri...		Others
T76780	Onartuzumab	RG-3638,PRO-14396,MetMAb	c-Met/HGFR
	Onartuzumab (MetMAb) is a humanized anti-tyrosine kinase c-MET monovalent monoclonal antibody.Onartuzumab has antitumor activity with inhibitory effects on HGF binding, receptor phosphorylation, and signal transduction.		c-Met/HGFR
T38617L	Biotin-TAT (47-57) acetate	Biotin-TAT (47-57) acetate(1231898-25-1 free base)	Others
	Biotin-TAT (47-57) acetate is a biotin-labeled TAT polypeptide and a transactivator of transcription. Biotin-TAT (47-57) acetate is one of the most widely used peptides in protein transduction domains.		Others
T41094	Wnt/β-catenin agonist 2		GSK-3 , Wnt/beta-catenin
	Wnt/β-catenin agonist 2 activates Wnt/β-catenin signaling and is an effective Wnt agonist. Wnt/β-catenin agonist 2 can be used in the study of diseases related to signal transduction and is closely related to cancer inva...		GSK-3 , Wnt/beta-catenin
T6271	Tipifarnib	R115777,Zarnestra,IND 58359	Transferase
	Tipifarnib (IND 58359) is a nonpeptidomimetic quinolinone with potential antineoplastic activity. Tipifarnib binds to and inhibits the enzyme farnesyl protein transferase, an enzyme involved in protein processing (farnes...		Transferase
T2307	Icotinib Hydrochloride	BPI-2009H	EGFR
	Icotinib Hydrochloride (BPI-2009H) is the hydrochloride salt form of icotinib, an orally available quinazoline-based inhibitor of EGFR, with potential antineoplastic activity. Icotinib selectively inhibits the wild-type ...		EGFR
T76724	Nemolizumab	CIM331	Interleukin
	Nemolizumab (CIM331) is a humanized monoclonal antibody against human interleukin-31 receptor A that inhibits the binding and subsequent signal transduction of interleukin-31 (IL-31) to its receptor. Nemolizumab can be u...		Interleukin
T3455	Merestinib	LY2801653	Discoidin Domain Receptor (DDR) , FLT , c-Met/HGFR , ROS , ROS Kinase
	Merestinib (LY2801653) is an orally available, small molecule inhibitor of the proto-oncogene c-Met (Ki: 2 nM) with potential antineoplastic activity. Merestinib electively binds to c-Met, thereby inhibiting c-Met phosph...
T61111	UCB-5307		TNF
	UCB-5307 is a small molecule compound that inhibits TNFR1 signal transduction and downstream function in vitro. The KD of human TNFα is 9 nM. The TNF was directly bound by slow binding kinetics,KD= 6 nM. UCB-5307 can pas...		TNF
T2078	Fimepinostat	CUDC-907,PI3K/HDAC Inhibitor,CUDC 907	Apoptosis , PI3K , HDAC
	Fimepinostat (CUDC 907) is an orally bioavailable inhibitor of both phosphoinositide 3-kinase (PI3K) class I and pan-histone deacetylase (HDAC) enzymes, with potential antineoplastic activity. Upon oral administration, C...		Apoptosis , PI3K , HDAC
T40423	L48H37
	L48H37 is a chemically stable analog of Curcumin. It exhibits potent inhibitory properties against myeloid differentiation protein 2 (MD2), acting as a specific inhibitor. Its mechanism involves inhibiting the interactio...
TP1991L	M 1145 acetate		Neuropeptide Y Receptor
	M1145 acetate, a chimeric peptide, is a selective galanin receptor type 2 (GAL2) agonist, with a Ki of 6.55 nM. M1145 acetate shows more than 90-fold higher affinity for GAL2 over GAL1 (Ki=587 nM) and a 76-fold higher af...		Neuropeptide Y Receptor
T14871	Carboxyamidotriazole Orotate	L-651582 Orotate,CAI Orotate	Calcium Channel
	Carboxyamidotriazole Orotate (L-651582 Orotate) is a cytostatic inhibitor of non-voltage-operated calcium channels and calcium channel-mediated signaling pathways. Carboxyamidotriazole Orotate (L-651582 Orotate) is the o...		Calcium Channel
T35349	CU-CPD107	CU-CPD107	TLR
	CU-CPD107 is a selective agonist of toll-like receptor 8 (TLR8) and also shows activation activity against ssRNA ligands. CU-CPD107 acts as an inhibitor of TLR8 signaling in the presence of R848 (IC50=13.7 μM). CU-CPD10...		TLR
T22796	Galiellalactone		Others
	inhibits IL-6-mediated JAK/STAT signal transduction		Others
T31159	Cysteinesulfenic acid	L-Alanine, 3-sulfeno-,L-Cysteine sulfoxide,L-Cysteinesulfenic acid,S-(Propylcarbamoyl)cysteine
	Cysteinesulfenic acid is a protein-sulfenic acid involved in enzyme catalysis, redox regulation, and signal transduction.
T38617	Biotin-TAT (47-57)
	Biotin-TAT (47-57) is a biotin-tagged transactivator of transcription, commonly employed as a protein transduction domain (PTD) in various primary cells. Its transduction capacity is contingent on ATP and temperature, su...
T68442	Desacetylravidomycin
	Desacetylravidomycin is a new inhibitor of IL-4 signal transduction, produced by Streptomyces sp. WK-6326.
T69626	L6H21
	L6H21 is an inhibitor of the interaction and signaling transduction of LPS-TLR4/MD-2 (myeloid differentiation 2).
T82422	F1874-108
	F1874-108 functions as an inhibitor of both brassinosteroid biosynthesis and signal transduction [1].
T61247	TRK-IN-16
	TRK-IN-16 (WO2012034091A1, compound X-21) is a highly effective TRK inhibitor, targeting protein kinases that are integral to regulating cell growth, differentiation, and various cellular signal transduction processes. ...
T28511	Reglitazar	JTT-501,JTT501,PNU-182716,PNU182716,PNU-716
	Reglitazar is a PPARɑ agonist and PPARγ agonist. Reglitazar rapidly stimulates glucose disposal rates by enhancing insulin signal transduction in skeletal muscle. Reglitazar improves insulin resistance in genetic and non...
T74394	Flupyradifurone
	Flupyradifurone, a systemic nicotinic acetylcholine receptor (nAChR) agonist, disrupts signal transduction within the central nervous system of sucking pests, functioning as a butenolide insecticide [1].
T37028	PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl) (sodium salt)	PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl) (sodium salt)
	The phosphatidylinositol phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(3,4,5)-P3 can serve as ...
TP1185	Cys-TAT(47-57)	Cys-[HIV-Tat (47-57)]
	Cys-TAT(47-57) (Cys-[HIV-Tat (47-57)]) is an arginine rich cell penetrating peptide derived from the HIV-1 transactivating protein.This peptide corresponds to the protein transduction domain of the TAT protein.
T68600	Enoximone sulfoxide
	Enoximone sulfoxide is a selective phosphodiesterase III (PDE3) inhibitor with vasodilating and positive inotropic activity that does not cause changes in myocardial oxygen consumption. Enoximone prevents the degradation...
TP1991	M1145	M 1145
	Potent and selective galanin receptor 2 (GAL2) agonist (EC50 = 38 nM, Ki values are 6.55, 497 and 587 nM at GAL2, GAL3 and GAL1 respectively). Has an additive effect on the signal transduction of galanin.
T61246	TRK-IN-15
	TRK-IN-15 (WO2012034091A1, compound X-55) is a highly effective inhibitor of TRK, a protein kinase with crucial involvement in the regulation of cellular growth, differentiation, and signal transduction. Offering signifi...
T4402	(4-Chloro-thiazol-2-yl)acetic acid		Others
	(4-Chloro-thiazol-2-yl)acetic acid has been used in a variety of scientific research applications, including protein folding, enzyme inhibition and signal transduction.		Others
T82612	Dansyl ethylenediamine
	Dansyl ethylenediamine, a fluorescent probe, is utilized in the synthesis of protein-imprinted polymers for the specific transduction of protein binding events into a change of fluorescent signal [1].
T76764	Tovetumab
	Tovetumab (MEDI-575), an anti-PDGFRα monoclonal antibody, selectively inhibits PDGFRα signal transduction. It is utilized in studying glioblastoma and non-small cell lung cancer (NSCLC) [1] [2].
T74943	SARS-CoV-2-IN-25
	SARS-CoV-2-IN-25 (Compound CP026) is a potent inhibitor, specifically targeting the transduction of SARS-CoV-2 spike pseudoparticles, with an inhibitory concentration (IC50) of 1.6 μM. It effectively inhibits enveloped v...
T76387	Protein kinase C substrate
	Protein Kinase C substrate, a specific substrate of Protein Kinase C, plays a pivotal role in signal transduction by facilitating the detection of protein through its enzyme's catalytic action on specific substrate phosp...
T35933	D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt)	D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt),Ins(1,4,5,6)-P4
	D-myo-Inositol-1,4,5,6-tetrahosphate (sodium salt) (Ins(1,4,5,6)-P4) is one of several different inositol oligophosphate isomers implicated in signal transduction. Production of Ins(1,4,5,6)-P4 by intestinal epithelial c...
T61701	SHP2-IN-9
	SHP2-IN-9 is a potent inhibitor (IC50 = 1.174 μM) specifically targeting the SHP2 protein, displaying improved penetration across the blood-brain barrier. It exhibits a remarkable 85-fold selectivity for SHP2 over SHP1. ...
T80222	TAT-BH4 (Bcl-xL) (TFA)		Apoptosis
	"TAT-BH4 (Bcl-xL) TFA, primarily localized at the mitochondria, inhibits apoptotic cell death. This compound comprises an eosin-labeled cysteine at the N-terminal and the protein transduction domain from the HIV TAT prot...		Apoptosis
T69469	Panepoxydone
	Panepoxydone, an inhibitor of NF-κB activation, disrupts NF-κB-mediated signal transduction through the inhibition of IκB phosphorylation. Displaying antitumor, anti-inflammatory, antimalarial, and anti-parasitic activit...
T78561	M62812 free base
	M62812 (free base), a Toll-like receptor 4 (TLR4) signal transduction inhibitor, suppresses activation of endothelial cells and leukocytes and prevents lethal septic shock in mice. It is utilized in sepsis research [1].
T77176	Elgemtumab
	Elgemtumab (LJM716) is a fully human IgG monoclonal antibody that specifically targets HER3, inhibiting both ligand-dependent and independent HER3 signal transduction and cell proliferation. This function showcases its s...
T22197	CFM 1571 hydrochloride
	CFM 1571 hydrochloride is a chemical compound that acts as a stimulator of the nitric oxide receptor known as soluble guanylate cyclase (sGC). It demonstrates an EC50 value of 5.49 μM and an IC50 value of 2.84 μM. Solubl...
T77032	Imsidolimab
	Imsidolimab (ANB 019), a high-affinity, humanized monoclonal antibody targeting IL-36R, antagonizes IL-36 cytokine signal transduction, showing potential in treating generalized pustular psoriasis (GPP) and other inflamm...
T74943L	SARS-CoV-2-IN-25 disodium
	SARS-CoV-2-IN-25 (Compound CP026) disodium, a potent inhibitor of SARS-CoV-2 spike pseudoparticle transduction, demonstrates significant efficacy with an IC50 value of 1.6 μM. Additionally, it effectively inhibits envelo...
T82239	HAP-1
	HAP-1, a synovial-targeted transduction peptide, selectively mediates the internalization of protein complexes into synovial cells of human and rabbit origin. When fused with the antimicrobial peptide (KLAK)2, HAP-1 form...
T61882	AT791
	AT791 is an effective TLR7 and TLR9 inhibitor with oral activity. AT791 has inhibitory effects on TLR7 and TLR9 signal transduction in various types of human and mouse cells. AT791 inhibits DNA-TLR9 interaction in vitro.

Compounds

Target: TRP/TRPV Channel

AMG-47a

T7123

Synonym:

Target: VEGFR, p38 MAPK, JAK, Src

MRT67307

T0097

Synonym: MRT67307 HCl

Target: IκB/IKK, Autophagy

SU5214

T3569

Synonym: SU 5214

Target: VEGFR, Tyrosinase

ALE-0540

T9292

Synonym: ALE0540

Target: Others, Trk receptor

Pimecrolimus

T2648

Synonym: SDZ-ASM 981,ASM 981

Target: Others

Onartuzumab

T76780

Synonym: RG-3638,PRO-14396,MetMAb

Target: c-Met/HGFR

Biotin-TAT (47-57) acetate

T38617L

Synonym: Biotin-TAT (47-57) acetate(1231898-25-1 free base)

Target: Others

Wnt/β-catenin agonist 2

T41094

Synonym:

Target: GSK-3, Wnt/beta-catenin

Tipifarnib

T6271

Synonym: R115777,Zarnestra,IND 58359

Target: Transferase

Icotinib Hydrochloride

Target: Discoidin Domain Receptor (DDR), FLT, c-Met/HGFR, ROS, ROS Kinase

Synonym: CUDC-907,PI3K/HDAC Inhibitor,CUDC 907

Target: Apoptosis, PI3K, HDAC

Target: Neuropeptide Y Receptor

Carboxyamidotriazole Orotate

T14871

Synonym: L-651582 Orotate,CAI Orotate

Target: Calcium Channel

Cysteinesulfenic acid

T31159

Synonym: L-Alanine, 3-sulfeno-,L-Cysteine sulfoxide,L-Cysteinesulfenic acid,S-(Propylcarbamoyl)cysteine

Synonym: JTT-501,JTT501,PNU-182716,PNU182716,PNU-716

PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl) (sodium salt)

T37028

Synonym: PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl) (sodium salt)

Target:

Cys-TAT(47-57)

TP1185

Synonym: Cys-[HIV-Tat (47-57)]

(4-Chloro-thiazol-2-yl)acetic acid

T4402

Synonym:

Target: Others

Dansyl ethylenediamine

Protein kinase C substrate

T76387

Synonym:

Target:

D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt)

T35933

Synonym: D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt),Ins(1,4,5,6)-P4

TAT-BH4 (Bcl-xL) (TFA)

CFM 1571 hydrochloride

SARS-CoV-2-IN-25 disodium

カタログ番号	製品名	別名	ターゲット
TN1417	Azadirachtin		Apoptosis , Antifection
	Azadirachtin has antifungal activity, used as an insecticide.		Apoptosis , Antifection
T3364	Veratramine	NSC17821,NSC23880	Sodium Channel
	Veratramine (NSC-23880)(NSC-17821; NSC-23880) is a potent signal transduction inhibitor for treating tumors.		Sodium Channel
T6S1844	Tenacissoside H	Tenacissimoside C	Others
	Tenacissoside H (Tenacissimoside C) has antitumor activity on esophageal cancer through arresting cell cycle and regulating PI3K/Akt-NF-κB transduction cascade.		Others
T3406	Kuromanin chloride	Glucocyanidin chloride,Chrysontemin,Chrysontemin chloride,Cyanidin 3-O-glucoside chloride	NF-κB
	Kuromanin chloride (Chrysontemin chloride) is potent antioxidants and free radical scavengers, may act as modulators of gene regulation and signal transduction pathways.		NF-κB
TN1134	Euscaphic acid		Apoptosis , LDL , PI3K , DNA/RNA Synthesis , NO Synthase , Prostaglandin Receptor
	Euscaphic acid has anti-diabetic, and anti-inflammatory activities, it inhibits LPS-induced inflammatory responses by interference with the clustering of TRAF6 with IRAK1 and TAK1, resulting in blocking the activation of...
T2133	Adenosine monophosphate	5'-Adenylic acid,AMP,Adenosine 5'-monophosphate	Endogenous Metabolite , AMPK
	Adenosine monophosphate (AMP) is a purine ribonucleoside 5'-monophosphates and a key cellular metabolite in signal transduction and regulation of energy homeostasis.It has a role as an EC 3.1.3.11 (fructose-bisphosphatas...		Endogenous Metabolite , AMPK
T20879	Tacrolimus monohydrate	FK-506,FR 900506,Prograf,FR900506,Tacrolimus hydrate,LCP-Tacro,FK 506	Phosphatase , Others , Antibacterial , Antibiotic , Autophagy
	Tacrolimus monohydrate (LCP-Tacro) is a macrolide from the culture broth of a strain of Streptomyces tsukubaensis, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, whi...
T4969	Guanosine 5'-triphosphate trisodium salt	GTP Trisodium salt,5'-GTP trisodium salt	Endogenous Metabolite
	Guanosine 5'-triphosphate trisodium salt (5'-GTP trisodium salt) activates the signal transducing G proteins which are involved in various cellular processes including proliferation, differentiation, and activation of se...		Endogenous Metabolite
T6S1917	Schisandrol B	Gomisin A,TJN-101,Besigomsin,Gamma-Schisandrin,Schizandrol B,Wuweizi alcohol-B	P450 , Reactive Oxygen Species , Autophagy
	1. Schisandrol B (Besigomsin) may exert neuroprotective effects by attenuating the microglia-mediated neuroinflammatory response via inhibiting the TLR4-mediated NF-κB and MAPKs signaling pathways. 2. Schisandrol B has a...		P450 , Reactive Oxygen Species , Autophagy
T17273	YM-254890		Others
	YM-254890 inhibits platelet aggregation induced by ADP by blocking the P2Y1 signal transduction pathway (IC50: below 0.6 μM). YM-254890 is a selective Gαq/11 protein inhibitor. YM-254890 displays no inhibition of other G...		Others
TN1550	Danshenxinkun A		Others
	Danshenxinkun A, Danshenxinkun B and Neocryptotanshinone may intervene thrombotic diseases by adjusting the targets mainly involved in pathways of endocrine system, signal transduction, signaling molecules and interactio...		Others
T4700	1,3,5-Trihydroxy-4-prenylxanthone
	1,3,5-Trihydroxy-4-prenylxanthone is a relatively potent inhibitor of phosphodiesterase type 5 (PDE5), with an IC50 value of 3.0 μM; it shows in vitro inhibitory activity against acetylcholinesterase (AChE) and butyrylch...

天然物製品

Azadirachtin

TN1417

Synonym:

Target: Apoptosis, Antifection

Veratramine

T3364

Synonym: NSC17821,NSC23880

Target: Sodium Channel

Tenacissoside H

T6S1844

Synonym: Tenacissimoside C

Target: Others

Kuromanin chloride

T3406

Synonym: Glucocyanidin chloride,Chrysontemin,Chrysontemin chloride,Cyanidin 3-O-glucoside chloride

Target: Apoptosis, LDL, PI3K, DNA/RNA Synthesis, NO Synthase, Prostaglandin Receptor

Adenosine monophosphate

T2133

Synonym: 5'-Adenylic acid,AMP,Adenosine 5'-monophosphate

Target: Endogenous Metabolite, AMPK

Tacrolimus monohydrate

T20879

Synonym: FK-506,FR 900506,Prograf,FR900506,Tacrolimus hydrate,LCP-Tacro,FK 506

Target: Phosphatase, Others, Antibacterial, Antibiotic, Autophagy

Guanosine 5'-triphosphate trisodium salt

T4969

Synonym: GTP Trisodium salt,5'-GTP trisodium salt

Target: Endogenous Metabolite

Schisandrol B

T6S1917

Synonym: Gomisin A,TJN-101,Besigomsin,Gamma-Schisandrin,Schizandrol B,Wuweizi alcohol-B

Target: P450, Reactive Oxygen Species, Autophagy

1,3,5-Trihydroxy-4-prenylxanthone

T4700

Synonym:

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPH-01029	CAPN1 Protein, Human, Recombinant (His)	Human	E. coli
	Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-387' and 'His...
TMPH-01031	CAPN2 Protein, Human, Recombinant (His)	Human	E. coli
	Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cle...
TMPJ-00261	TGF beta 2 Protein, Mouse/Rat, Recombinant	Mouse,Rat	HEK293 Cells
	Transforming growth factor beta 2 (TGF-β2) is a member of TGF-beta superfamily that shares a characteristic cysteine knot structure. Mice with TGF-β2 gene deletion show defects in development of cardiac, lung, craniofaci...
TMPJ-00059	IL-7 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL7 can associate with the hepatocyte growth factor (HGF) to form a hybrid cytokine that functions...
TMPJ-01430	NovoNectin Protein, Human, Recombinant	Human	E. coli
	Fibronectin1(FN1) is a secreted protein and contains 12 fibronectin type-I domains,fibronectin type-II domains and 16 fibronectin type-III domains.Recombinant human fibronectin fragment, is a protein of ~63 kDa containin...
TMPJ-00154	IL-15RA Protein, Mouse, Recombinant (hFc, Human Cells)	Mouse	HEK293 Cells
	Mouse interleukin-15 receptor subunit alpha, also known as Il15ra, is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits (Common gamma chain, o...
TMPY-02585	Acid sphingomyelinase/SMPD1 Protein, Mouse, Recombinant (His)	Mouse	Baculovirus Insect Cells
	Sphingomyelin phosphodiesterase 1 (SMPD1) , also known as ASM ( acid sphingomyelinase ), is a member of the acid sphingomyelinase family of enzymes. Three isoforms have been identified, isoform 1 is 631 amino acids (aa) ...
TMPY-02904	TLR4 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	TLR4, also known as TLR-4, is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans...
TMPY-01648	TREML2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Trem-like transcript 2 protein, also known as Triggering receptor expressed on myeloid cells-like protein 2, TREML2 and TLT2, is a single-pass type I membrane protein that contains one Ig-like V-type (immunoglobulin-like...
TMPY-01806	CD9 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPJ-01461	IL-15RA & IL-15 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	IL15RA is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits to initiate signal transduction. It can signal both in cis and trans where IL15R f...
TMPJ-01462	IL-15RA & IL-15 Protein, Human, Recombinant - PBS Lyophilized (hFc)	Human	HEK293 Cells
	IL15RA is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits to initiate signal transduction. It can signal both in cis and trans where IL15R f...
TMPJ-00223	SLAMF1 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in...
TMPH-00379	MLCK Protein, Chicken, Recombinant (His & Myc & SUMO)	Chicken	E. coli
	Phosphorylates a specific serine in the N-terminus of a myosin light chain, which leads to the formation of calmodulin/MLCK signal transduction complexes which allow selective transduction of calcium signals. MLCK Protei...
TMPH-02277	PTPN11 Protein, Human, Recombinant (T253M & Q257L, His)	Human	E. coli
	Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosph...
TMPY-04562	GRK2 Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	G-protein coupled receptor kinase 2 (GRK2), also referred as Adrenergic, beta, receptor kinase 1 (ADRBK1), is a ubiquitous member of the G protein-coupled receptor kinase (GRK) family that appears to play a central, inte...
TMPH-02557	CAPN1 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-388' and 'His...
TMPH-00104	NLP7 Protein, Arabidopsis thaliana, Recombinant (His)	Arabidopsis thaliana	Baculovirus Insect Cells
	Transcription factor involved in regulation of nitrate assimilation and in transduction of the nitrate signal. NLP7 Protein, Arabidopsis thaliana, Recombinant (His) is expressed in Baculovirus insect cells with N-10xHis ...
TMPH-03234	Acetylcholinesterase Protein, Rat, Recombinant (His)	Rat	E. coli
	Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Acetylcholinesterase Protein, Rat, Recombinant (His) is expressed in E. coli express...
TMPH-03397	UPAR/PLAUR Protein, Rat, Recombinant (His)	Rat	E. coli
	Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. uPAR/PLAUR Protein,...
TMPH-03458	STE11 Protein, S. cerevisiae, Recombinant	Saccharomyces cerevisiae	E. coli
	Serine/threonine protein kinase required for cell-type-specific transcription and signal transduction in yeast. It is thought that it phosphorylates the STE7 protein kinase which itself, phosphorylates the FUS3 and or KS...
TMPJ-00089	CD3 epsilon/CD3e Protein, Human, Recombinant (hFc & Avi), Biotinylated	Human	HEK293 Cells
	T-Cell Surface Glycoprotein CD3 ε Chain (CD3ε) is a single-pass type I membrane protein. CD3ε contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3ε is a polypeptide encoded by the CD3E gene on chromosom...
TMPK-00514	IL-18RAP Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	IL-18RAP, also known as IL-18Rβ or IL-1R7, is component of IL-18 receptor complex and its interactions with IL-18R1 mediate signal transduction initiated by IL-18 although it does not directly bind IL-18 in vitro.
TMPK-00136	ULBP-2 Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, E...
TMPJ-01003	STAT5B Protein, Human, Recombinant (His)	Human	E. coli
	Signal Transducer and Activator of Transcription 5b (STAT5B) is a member of the STAT family of transcription factors. They are responsible for an array of cellular activities including regulating growth, survival, differ...
TMPH-02330	Zyxin Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal ...
TMPJ-00231	LRG1 Protein, Human, Recombinant (hFc & His)	Human	HEK293 Cells
	LRG1 is a secreted protein and contains eight LRR repeats and one LRRCT domain, It can be expressed during granulocyte differentiation. LRG1 has been shown to be involved in protein-protein interaction, signal transducti...
TMPJ-01381	ANXA10 Protein, Human, Recombinant	Human	E. coli
	Annexin A10 (ANXA10) contains four Annexin repeats and is a member of the Annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in sign...
TMPH-02575	PDE5A Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-gen...
TMPH-02430	SNCG Protein, Cynomolgus, Recombinant	Cynomolgus	E. coli
	Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent prote...
TMPK-00356	IL-27RA/TCCR Protein, Human, Recombinant (His)	Human	HEK293 Cells
	IL-27Ra (also known as TCCR and WSX1) as a gene whose expression can induce the transformation of hematopoietic cells. IL-27Ra (IL-27R) is a type I cytokine receptor that functions as the ligand binding component of the ...
TMPJ-00984	INPP1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Inositol Polyphosphate 1-Phosphatase (INPP1) is a member of the inositol monophosphatase family. INPP1 is widely expressed in tissues, with highest expression levels observed in the pancreas and kidney. INPP1 is inhibite...
TMPY-03978	TSPAN31 Protein, Human, Recombinant (mFc)	Human	HEK293 Cells
	TSPAN31 is a member of the transmembrane 4 superfamily. Most members of this family are cell-surface proteins that are characterized by the presence of four hydrophobic domains. They mediate signal transduction events th...
TMPH-01370	SNCG Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent prote...
TMPK-00745	PGLYRP1 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Innate immunity protein Tag7 (PGRP-S, PGLYRP1) can interact with the TNFα receptor, TNFR1, and block the transduction of apoptotic signals through this receptor. A complex formed between the Tag7 protein and the major he...
TMPH-03398	VCAM-1 Protein, Rat, Recombinant (His)	Rat	E. coli
	Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The ...
TMPJ-00608	SLAMF9 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Mouse SLAM family member 9(Slamf9) is a single-pass type I membrane protein. The SLAMF9 gene encodes a member of the signaling lymphocytic activation molecule family. The encoded protein is a cell surface molecule that c...
TMPK-00089	IL-11 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	Abstract Interleukin-11 (IL-11) is a pleiotropic cytokine that belongs to gp130 family. IL-11 and its receptor, IL-11Ra, are expressed in human cancers,human cancer cells expressed a functional IL-11Ra subunit, which tri...
TMPK-00749	PGLYRP1 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	Innate immunity protein Tag7 (PGRP-S, PGLYRP1) can interact with the TNFα receptor, TNFR1, and block the transduction of apoptotic signals through this receptor. A complex formed between the Tag7 protein and the major he...
TMPK-00088	IL-11 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Abstract Interleukin-11 (IL-11) is a pleiotropic cytokine that belongs to gp130 family. IL-11 and its receptor, IL-11Ra, are expressed in human cancers,human cancer cells expressed a functional IL-11Ra subunit, which tri...
TMPJ-00799	ANXA2 Protein, Human, Recombinant	Human	E. coli
	Annexin A2 (ANXA2) is a member of the annexin family and has roles in the regulation of cellular growth and in signal transduction pathways. ANXA2 protein is associated with sickle cell osteonecrosis and the expression r...
TMPJ-00377	VCAM-1 Protein, Human, Recombinant (Avi & His), Biotinylated	Human	HEK293 Cells
	VCAM-1 (CD106, INCAM-110) is a cell adhesion molecule and a member of the immunoglobulin superfamily. It's important function is a recognition of cell-cell. Appears to function in leukocyte-endothelial cell adhesion. Int...
TMPK-00329	TGFBR2 Protein, Human, Recombinant (mFc & Avi), Biotinylated	Human	HEK293 Cells
	The TGFBR2 gene provides instructions for making a protein called transforming growth factor-beta (TGF-β) receptor type 2. This receptor transmits signals from the cell surface into the cell through a process called sign...
TMPK-00988	ECSCR Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	Endothelial cell-specific chemotaxis receptor (ECSCR) is a cell surface protein expressed by blood endothelial cells with roles in endothelial cell migration and signal transduction. Zebrafish ecscr is expressed in angio...
TMPH-02020	RGS17 Protein, Human, Recombinant (GST)	Human	E. coli
	Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G pro...
TMPH-02732	IFNAR2 Protein, Mouse, Recombinant (His)	Mouse	P. pastoris (Yeast)
	Associates with IFNAR1 to form the plasma membrane receptor in the type I interferon signaling pathway. Directly involved in signal transduction through its association with the TYR kinase JAK1. Involved in interferon-me...
TMPY-02194	SOCS3 Protein, Human, Recombinant (His & Trx)	Human	E. coli
	Suppressor of cytokine signaling 3, also known as SOCS-3, Cytokine-inducible SH2 protein 3, CIS-3, STAT-induced STAT inhibitor 3, SOCS3 and CIS3, is a protein which is widely expressed with high expression in heart, plac...
TMPJ-01412	LRP-12 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Low-Density Lipoprotein Receptor-Related Protein 12 (LRP12) belongs to the LDLR family. LRP12 is a type I transmembrane protein annd widely expressed in heart, skeletal muscle, brain, lung, placenta and pancreas. LRP12 c...
TMPJ-00590	ANXA13 Protein, Human, Recombinant	Human	E. coli
	Annexin A13 (ANXA13) belongs to the annexin family which plays a role in phospholipase inhibition, cytoskeletal interactions, intracellular signal transduction pathways and regulation of cellular growth. ANXA13 contains ...
TMPJ-01050	GRB2 Protein, Human, Recombinant (His)	Human	E. coli
	As an adaptor protein, Growth Factor Receptor-Bound Protein 2 (GRB2) is involved in siganl transduction and consists of a central SH2 domain flanked by two SH3 domains. GRB2 associates with activated Tyr-phosphorylated E...
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CAPN1 Protein, Human, Recombinant (His)

TMPH-01029

Species: Human

Expression System: E. coli

CAPN2 Protein, Human, Recombinant (His)

TMPH-01031

Species: Human

Expression System: E. coli

TGF beta 2 Protein, Mouse/Rat, Recombinant

TMPJ-00261

Species: Mouse,Rat

Expression System: HEK293 Cells

IL-7 Protein, Human, Recombinant (His)

TMPJ-00059

Species: Human

Expression System: HEK293 Cells

NovoNectin Protein, Human, Recombinant

TMPJ-01430

Species: Human

Expression System: E. coli

IL-15RA Protein, Mouse, Recombinant (hFc, Human Cells)

TMPJ-00154

Species: Mouse

Expression System: HEK293 Cells

Acid sphingomyelinase/SMPD1 Protein, Mouse, Recombinant (His)

TMPY-02585

Species: Mouse

Expression System: Baculovirus Insect Cells

TLR4 Protein, Human, Recombinant (His)

TMPY-02904

Species: Human

Expression System: Baculovirus Insect Cells

TREML2 Protein, Human, Recombinant (His)

TMPY-01648

Species: Human

Expression System: HEK293 Cells

CD9 Protein, Human, Recombinant (His)

TMPY-01806

Species: Human

Expression System: HEK293 Cells

IL-15RA & IL-15 Protein, Human, Recombinant (hFc)

TMPJ-01461

Species: Human

Expression System: HEK293 Cells

IL-15RA & IL-15 Protein, Human, Recombinant - PBS Lyophilized (hFc)

TMPJ-01462

Species: Human

Expression System: HEK293 Cells

SLAMF1 Protein, Human, Recombinant (His & Avi), Biotinylated

TMPJ-00223

Species: Human

Expression System: HEK293 Cells

MLCK Protein, Chicken, Recombinant (His & Myc & SUMO)

TMPH-00379

Species: Chicken

Expression System: E. coli

PTPN11 Protein, Human, Recombinant (T253M & Q257L, His)

TMPH-02277

Species: Human

Expression System: E. coli

GRK2 Protein, Human, Recombinant (His & GST)

TMPY-04562

Species: Human

Expression System: Baculovirus Insect Cells

CAPN1 Protein, Mouse, Recombinant (His)

TMPH-02557

Species: Mouse

Expression System: E. coli

NLP7 Protein, Arabidopsis thaliana, Recombinant (His)

TMPH-00104

Species: Arabidopsis thaliana

Expression System: Baculovirus Insect Cells

Acetylcholinesterase Protein, Rat, Recombinant (His)

TMPH-03234

Species: Rat

Expression System: E. coli

uPAR/PLAUR Protein, Rat, Recombinant (His)

TMPH-03397

Species: Rat

Expression System: E. coli

STE11 Protein, S. cerevisiae, Recombinant

TMPH-03458

Species: Saccharomyces cerevisiae

Expression System: E. coli

CD3 epsilon/CD3e Protein, Human, Recombinant (hFc & Avi), Biotinylated

TMPJ-00089

Species: Human

Expression System: HEK293 Cells

IL-18RAP Protein, Cynomolgus, Recombinant (His)

TMPK-00514

Species: Cynomolgus

Expression System: HEK293 Cells

ULBP-2 Protein, Human, Recombinant (His & Avi)

TMPK-00136

Species: Human

Expression System: HEK293 Cells

STAT5B Protein, Human, Recombinant (His)

TMPJ-01003

Species: Human

Expression System: E. coli

Zyxin Protein, Human, Recombinant (His)

TMPH-02330

Species: Human

Expression System: HEK293 Cells

LRG1 Protein, Human, Recombinant (hFc & His)

TMPJ-00231

Species: Human

Expression System: HEK293 Cells

ANXA10 Protein, Human, Recombinant

TMPJ-01381

Species: Human

Expression System: E. coli

PDE5A Protein, Mouse, Recombinant (His & Myc)

TMPH-02575

Species: Mouse

Expression System: E. coli

SNCG Protein, Cynomolgus, Recombinant

TMPH-02430

Species: Cynomolgus

Expression System: E. coli

IL-27RA/TCCR Protein, Human, Recombinant (His)

TMPK-00356

Species: Human

Expression System: HEK293 Cells

INPP1 Protein, Human, Recombinant (His)

TMPJ-00984

Species: Human

Expression System: HEK293 Cells

TSPAN31 Protein, Human, Recombinant (mFc)

TMPY-03978

Species: Human

Expression System: HEK293 Cells

SNCG Protein, Human, Recombinant (His & SUMO)

TMPH-01370

Species: Human

Expression System: E. coli

PGLYRP1 Protein, Human, Recombinant (hFc)

TMPK-00745

Species: Human

Expression System: HEK293 Cells

VCAM-1 Protein, Rat, Recombinant (His)

TMPH-03398

Species: Rat

Expression System: E. coli

SLAMF9 Protein, Mouse, Recombinant (His)

TMPJ-00608

Species: Mouse

Expression System: HEK293 Cells

IL-11 Protein, Cynomolgus, Recombinant (His)

TMPK-00089

Species: Cynomolgus

Expression System: HEK293 Cells

PGLYRP1 Protein, Mouse, Recombinant (hFc)

TMPK-00749

Species: Mouse

Expression System: HEK293 Cells

IL-11 Protein, Human, Recombinant (His)

TMPK-00088

Species: Human

Expression System: HEK293 Cells

ANXA2 Protein, Human, Recombinant

TMPJ-00799

Species: Human

Expression System: E. coli

VCAM-1 Protein, Human, Recombinant (Avi & His), Biotinylated

TMPJ-00377

Species: Human

Expression System: HEK293 Cells

TGFBR2 Protein, Human, Recombinant (mFc & Avi), Biotinylated

TMPK-00329

Species: Human

Expression System: HEK293 Cells

ECSCR Protein, Mouse, Recombinant (hFc)

TMPK-00988

Species: Mouse

Expression System: HEK293 Cells

RGS17 Protein, Human, Recombinant (GST)

TMPH-02020

Species: Human

Expression System: E. coli

IFNAR2 Protein, Mouse, Recombinant (His)

TMPH-02732

Species: Mouse

Expression System: P. pastoris (Yeast)

SOCS3 Protein, Human, Recombinant (His & Trx)

TMPY-02194

Species: Human

Expression System: E. coli

LRP-12 Protein, Human, Recombinant (His)

TMPJ-01412

Species: Human

Expression System: HEK293 Cells

ANXA13 Protein, Human, Recombinant

TMPJ-00590

Species: Human

Expression System: E. coli

GRB2 Protein, Human, Recombinant (His)

TMPJ-01050

Species: Human

Expression System: E. coli

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カタログ番号	製品名
L2200	Tyrosine Kinase Inhibitor Library	1016 compounds
	A unique collection of 1016 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase related diseases;
L1580	GPCR Compound Library Plus	338 compounds
	Well-chosen 338 GPCR targeting compounds with unique structures;
L1600	Kinase Inhibitor Library	2720 compounds
	A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;
L1500	GPCR Compound Library	1940 compounds
	A unique collection of 1940 GPCR-active agents for high throughput screening and high content screening for GPCR drug discovery, and new GPCR target identification and research;
L3700	JAK-STAT Compound Library	252 compounds
	A unique collection of 252 JAK/STAT signaling targeted compounds for high throughput and high content screening;
L1110	Microtubule-Targeted Compound Library	142 compounds
	A unique collection of 142 microtubule-targeted compounds can be used in HTS and HCS;
L7700	Neural Regeneration Compound Library	524 compounds
	A unique collection of 149 neuroregeneration related compounds for high throughput and high content screening;
L9600	Peptide Compound Library	791 compounds
	791 peptides can be used in peptide drug development and signaling transduction and mechanism study;