|
T9407 |
Rasarfin
|
|
Others
,
Ras
|
|
Rasarfin inhibits Ras and ARF6. |
|
T41256 |
SP-96
|
|
Aurora Kinase
|
|
SP-96 is a highly effective and selective inhibitor of Aurora B with an IC50 of 0.316 nM. SP-96 shows selective growth inhibition in NCI60 screening, including MDA-MD-468 (GI50=107 nM). SP-96 can be used in triple negati... |
|
T9468 |
FR054
|
|
Others
|
|
FR054 is an inhibitor of the Hexosamine Biosynthetic Pathway (HBP) enzyme PGM3, with a remarkable anti-breast cancer effect. FR054 induces in different breast cancer cells a dramatic decrease in cell proliferation and su... |
|
T10860 |
Col003
|
|
HSP
|
|
Col003 is a selective and potent inhibitor of Hsp47 and competitively binds to the collagen-binding site on Hsp47 (IC50: 1.8 μM). It can be used for the investigation of fibrosis. |
|
T13780 |
MS1943
|
|
Apoptosis
,
Histone Methyltransferase
|
|
MS1943 is a orally bioavailable EZH2 selective degrader(IC50 of 120 nM). |
|
T13044 |
Mevociclib
|
SY-1365 |
CDK
|
|
Mevociclib (SY-1365) is a highly selective covalent inhibitor of CDK7. SY-1365 possesses therapeutic potential in both hematological and solid tumors. |
|
T4123 |
LYN-1604
|
LYN1604 |
Apoptosis
,
Autophagy
|
|
LYN-1604 is a novel activator of ULK1, inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis. |
|
T6797 |
Telaglenastat
|
CB 839,CB839,CB-839 |
transporter
,
Glutaminase
,
Autophagy
|
|
Telaglenastat (CB 839) (IC50 of 24 nM), an effective, specific, and oral inhibitor, which is bioavailable glutaminase, for recombinant human GAC. |
|
T19664 |
ON1231320
|
GBO-006 |
Apoptosis
,
PLK
|
|
ON1231320 (GBO-006) is a Polo-like kinase 2 (PLK2) inhibitor. |
|
T7530 |
PD146176
|
NSC168807 |
Ferroptosis
,
Lipoxygenase
,
Autophagy
|
|
PD146176 (NSC-168807) is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM. PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology... |
|
T2655 |
CEP-37440
|
CEP37440 |
FAK
,
ALK
|
|
CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK). |
|
T9320 |
YK-3-237
|
B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid |
Sirtuin
|
|
YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) reduces acetylation of mtp53 and exhibits anti-proliferative effects toward triple-negative breast cancer (TNBC) cells ca... |
|
T8808L |
LYN-1604 dihydrochloride
|
LYN-1604 2HCl（2216753-86-3 free base) |
Apoptosis
,
Autophagy
|
|
LYN-1604 is a novel ULK1 activator.It inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis. |
|
T35528 |
TD52
|
|
Apoptosis
,
Phosphatase
,
Akt
|
|
TD52 is an orally active inhibitor of cancerous inhibitor of PP2A (CIP2A). TD52 is an Erlotinib derivative and indirectly reduced CIP2A by disturbing Elk1 binding to the CIP2A promoter. |
|
T70353 |
JG-231
|
|
HSP
|
|
JG-231 is a JG-98 analog with anticancer activity.JG-231 inhibits the MDA-MB-231 xenograft tumor model of triple-negative breast cancer (TNBC).JG-231 inhibits the interaction of Hsp70-BAG3.JG-231 inhibits the MDA-MB-231 ... |
|
T2092 |
Amitifadine hydrochloride
|
DOV-21947 hydrochloride,EB-1010 hydrochloride |
Dopamine Receptor
,
5-HT Receptor
,
Serotonin Transporter
,
Norepinephrine
|
|
Amitifadine hydrochloride (EB-1010 hydrochloride) is a triple reuptake inhibitor (TRI) or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI). |
|
T6224 |
Iniparib
|
NSC-746045,IND-71677,BSI-201 |
PARP
,
Influenza Virus
|
|
Iniparib (BSI-201) (BSI-201) , a PARP1 inhibitor, exhibits potency in triple-negative breast Y (TNBC). |
|
T8569 |
DMH-25
|
|
mTOR
|
|
DMH25 is a novel covalent and potent inhibitor of mTOR and shows in vivo antitumor activity against triple-negative breast cancer cells. |
|
T5001 |
Nintedanib esylate
|
Intedanib,BIBF 1120 (esylate),Nintedanib Ethanesulfonate Salt,BIBF 1120 |
VEGFR
,
FGFR
,
PDGFR
|
|
Nintedanib esylate (BIBF 1120 esylate) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β |
|
T9583 |
HJ-PI01
|
N-Acetylphenoxazine,10-acetylphenoxazine |
Pim
|
|
HJ-PI01 (HJ-PI01) is a Pim-2 inhibitor. HJ-PI01 (HJ-PI01) induces apoptosis and autophagic cell death in triple-negative human breast cancer. |
|
T7296 |
THZ2
|
CDK7-IN-1 |
CDK
|
|
THZ2 (CDK7-IN-1), an analog of THZ1, is a potent and selective CDK7 inhibitor(IC50:13.9 nM),with the potential to treat Triple-negative breast cancer (TNBC). |
|
T32737 |
Liafensine
|
BMS820836,BMS 820836,DB104,BMS-820836 |
Dopamine Receptor
,
5-HT Receptor
,
Norepinephrine
|
|
Liafensine(BMS-820836) is a novel and selective triple monoamine reuptake inhibitor with inhibitory effects on the reuptake of serotonin, norepinephrine, and dopamine for the study of major depressive disorder and centra... |
|
T74178 |
Glembatumumab vedotin
|
CR011-vcMMAE,CR 011 ADC,CDX-011 |
Microtubule Associated
|
|
Glembatumumab vedotin (CDX-011) is an antibody-activated small molecule coupling, Glembatumumab vedotin has potent anticancer effects and can be used in the study of triple negative breast cancer (TNBC). |
|
T3526 |
Dasotraline hydrochloride
|
SEP-225289 hydrochloride |
Dopamine Receptor
,
5-HT Receptor
,
Serotonin Transporter
,
Norepinephrine
|
|
Dasotraline hydrochloride (SEP-225289 hydrochloride) (SEP-225289 hydrochloride) is a triple reuptake inhibitor that inhibits dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respe... |
|
T77759 |
GPX4-IN-6
|
|
GPX
|
|
GPX4-IN-6 is a small molecule covalent GPX4 inhibitor (IC50: 0.12 μM) with antitumour activity.GPX4-IN-6 induces iron death and is used for the treatment= and prevention of triple negative breast cancer (TNBC). |
|
T72528 |
NSC243928 mesylate
|
|
HuR
|
|
NSC243928 mesylate binds to human lymphocyte antigen 6 (LY6), a cell growth inhibitor with anticancer activity, and induces cell death in triple-negative breast cancer cells in a LY6K-dependent manner. |
|
T8325 |
SR-4835
|
|
Apoptosis
,
CDK
|
|
SR-4835 is a highly selective dual inhibitor of CDK12 and CDK13(CDK12: IC50=99 nM, Kd=98 nM; CDK13: Kd=4.9 nM), which disables triple-negative breast cancer (TNBC) cells |
|
T14685 |
BMS-986158
|
|
Epigenetic Reader Domain
|
|
BMS-986158 is a highly effective BET inhibitor, demonstrating IC50 values of 6.6 nM in NCI-H211 small cell lung cancer (SCLC) cells and 5 nM in MDA-MB231 triple negative breast cancer (TNBC) cells. |
|
T77755 |
GPX4-IN-5
|
|
GPX
|
|
GPX4-IN-5 is a small molecule covalent GPX4 inhibitor (IC50: 0.12 μM) with antitumour activity.GPX4-IN-5 induces iron death and can be used for the prevention and treatment of triple-negative breast cancer (TNBC). |
|
T76279 |
Retatrutide
|
LY3437943 |
Glucagon Receptor
|
|
Retatrutide (LY3437943) is a triple agonist of the glucagon receptor, glucose-dependent insulinotropic polypeptide receptor, and glucagon-like peptide-1 receptor (GLP-1R), and inhibits GCGR, GIPR, and GLP-1R.Retatrutide ... |
|
T77342 |
GSK-3 inhibitor 3
|
|
GSK-3
,
Microtubule Associated
|
|
GSK-3 inhibitor 3 is a selective, orally active, brain-permeable GSK-3 inhibitor that inhibits GSK-3α and GSK-3β with IC50s of 0.35 nM and 0.25 nM, respectively.GSK-3 inhibitor 3 reduces the phosphorylation level of tau ... |
|
T11158 |
EGFR-IN-11
|
|
EGFR
|
|
EGFR-IN-11 is a selective inhibitor of EGFR-tyrosine kinase and induces cell apoptosis. EGFR-IN-11 inhibits triple mutant EGFRL858R/T790M/C797S with an IC50 of 18 nM and arrests cell cycle at G0/G1. |
|
T17206 |
UPGL00004
|
|
Others
,
Glutaminase
|
|
UPGL00004 is a potent glutaminase C (GAC) inhibitor with an IC50 of 29 nM. Kd of UPGL00004 for GAC was 27 nM. UPGL00004 has a strong inhibitory effect on the proliferation of highly aggressive triple negative breast canc... |
|
T76279L1 |
Retatrutide sodium salt
|
Retatrutide sodium salt(2381089-83-2 free base),LY3437943 sodium salt |
Glucagon Receptor
|
|
Retatrutide sodium salt is a potent triple agonist peptide for glucagon receptor (GCGR), glucose-dependent proinsulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R) Retatrutide sodium s... |
|
T1777 |
Nintedanib
|
BIBF 1120,Intedanib |
VEGFR
,
FGFR
,
FLT
,
PDGFR
,
Src
|
|
Nintedanib (Intedanib) is a triple vascular kinase inhibitor that inhibits VEGFR1, VEGFR2, and VEGFR3 (IC50=34/13/13 nM), FGFR1, FGFR2, and FGFR3 (IC50=69/37/108 nM), PDGFRα, and PDGFRβ (IC50=59/65 nM). Nintedanib has an... |
|
T35528L |
TD52 dihydrochloride
|
TD52 dihydrochloride(1798328-24-1 Free base),TD52 2HCl |
Others
|
|
TD52 dihydrochloride (TD52 2HCl), a derivative of Erlotinib, is a potent and orally active inhibitor of protein phosphatase 2A (CIP2A). It exhibits strong anti-cancer properties by regulating the CIP2A/PP2A/p-Akt signali... |
|
T62077 |
VT103
|
VT-103,VT 103 |
YAP
|
|
VT103 is an orally active and selective inhibitor of TEAD1 protein palmitoylation and is an analog of VT101. VT103 has potential antitumor activity by inhibiting YAP/TAZ-TEAD-promoted gene transcriptionment, blocking TEA... |
|
T3097 |
Mycophenolic Acid Impurity
|
5,7-dihydroxy-4-methylphthalide |
Others
|
|
Mycophenolic Acid Impurity (5,7-dihydroxy-4-methylphthalide) is an an immunosuppresant drug and potent anti-proliferative, and can be used in place of the older anti-proliferative azathioprine. It is usually used as part... |
|
T77341 |
GSK-3 inhibitor 4
|
|
GSK-3
,
CDK
|
|
GSK-3 inhibitor 4 is an orally active and brain-permeable triple inhibitor of GSK-3, CDK2 and CDK5 with inhibitory effects on GSK-3β, GSK-3α, CDK2 and CDK5, with IC50 values of 0.56 nM, 0.45 nM, 0.47 μM, 0.68 μM, respect... |
|
T10534 |
BI-4020
|
|
EGFR
|
|
|
|
T11600 |
IBR2
|
Isoquinoline |
DNA/RNA Synthesis
|
|
IBR2 (Isoquinoline) is a potent and specific RAD51 inhibitor known for its ability to suppress RAD51-mediated DNA double-strand break repair. By interfering with RAD51 multimerization, accelerating proteasome-mediated RA... |
|
T25467 |
GSK1360707
|
GSK-1360707,GSK 1360707 |
|
|
GSK1360707 is a selective triple reuptake inhibitor (TRI). |
|
T25232 |
CGS 35601
|
CGS-35601,CGS35601 |
|
|
CGS 35601 is a single molecule inhibitor of triple vasopeptidase. |
|
T30425 |
BePI
|
Be-PI,NSC 664711,NSC-664711,NSC664711,Be PI |
|
|
BePI can be a specific intercalator of both double and triple-helical DNA. |
|
T69852 |
CS-003 HCl
|
|
|
|
CS-003 HCl is a TNRA - triple neurokinin receptor antagonist. |
|
T38839 |
MCX 28
|
|
|
|
MCX 28, a triple PI3K/mTOR/PIM inhibitor, displays low nanomolar activity. |
|
T70341 |
D-473
|
|
|
|
D-473 is a novel orally active triple reuptake inhibitor targeting dopamine, serotonin and norepinephrine transporters. |
|
T40182 |
Ascochlorin A
|
Acremochlorin A |
|
|
Ascochlorin A, a compound with a dissociation constant (K D) of 3.29 μM, serves as a novel and potent human dihydroorotate dehydrogenase (hDHODH) inhibitor aimed at treating triple-negative breast cancer. |
|
T61179 |
EMI48
|
|
|
|
EMI48, a derivative of EMI1, exhibits increased efficacy against mutant EGFR compared to EMI1. It specifically inhibits EGFR triple mutants [1]. |
|
T35913 |
EMI56
|
|
|
|
EMI56, a derivative of EMI1, exhibits enhanced potency against mutant EGFR compared to EMI1. Additionally, EMI56 effectively inhibits EGFR triple mutants[1]. |
