|
T15675 |
Tirbanibulin Mesylate
|
KX2-391 Mesylate,KX01 Mesylate |
Microtubule Associated
,
Src
|
|
Tirbanibulin Mesylate (KX01 Mesylate) is an inhibitor of Src that targets the peptide substrate site of Src (GI50: 9-60 nM in cancer cell lines). |
|
T7212 |
Delavirdine mesylate
|
U 90152 (mesylate),BHAP-U 90152 (mesylate),Delavirdine (mesylate) |
HIV Protease
,
Reverse Transcriptase
|
|
Delavirdine mesylate (BHAP-U 90152 (mesylate)) is a non-nucleoside reverse transcriptase inhibitor (NNRTI). |
|
T11578L |
Encequidar mesylate
|
HM30181 mesylate,HM30181A mesylate |
P-gp
|
|
Encequidar mesylate (HM30181A mesylate) is a competitive P-glycoprotein inhibitor. |
|
T2346L |
Enasidenib mesylate
|
AG221 mesylate,AG 221 mesylate,AG-221 mesylate |
Dehydrogenase
|
|
Enasidenib mesylate (AG-221 mesylate) is a potent and selective IDH2 mutase inhibitor that promotes differentiation of leukemia myeloid cells for the treatment of acute myeloid leukemia. |
|
T0425 |
Pefloxacin Mesylate
|
Pefloxacinium mesylate |
Topoisomerase
,
Antibacterial
,
Antibiotic
|
|
Pefloxacin Mesylate (Pefloxacinium mesylate) is a synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-positive bacteria. |
|
T7547 |
Ralfinamide mesylate
|
FCE-26742A (mesylate) |
Sodium Channel
|
|
Ralfinamide mesylate (FCE-26742A (mesylate)) is an orally available Na+ channel blocker. |
|
T4342 |
PF-04929113 Mesylate
|
PF-04929113 (Mesylate),SNX-5422 Mesylate |
HSP
,
HER
|
|
PF-04929113 Mesylate (SNX-5422 Mesylate), a prodrug of SNX-2112, is an orally available Hsp90 inhibitor (Kd: 41 nM) and also induces Her-2 degradation (IC50: 37 nM). |
|
T11949 |
Masupirdine mesylate
|
SUVN-502 mesylate,SVN-502 mesylate |
5-HT Receptor
|
|
Masupirdine mesylate (SUVN-502 mesylate) is a selective 5-HT6 receptor antagonist that crosses the blood-brain barrier.Masupirdine mesylate is used in the study of neurological disorders such as Alzheimer's disease and d... |
|
T12059L |
Mitoquinone mesylate
|
MitoQ mesylate,MitoQ10 mesylate |
Reactive Oxygen Species
|
|
|
|
T13687 |
Eribulin mesylate
|
B1939 mesylate,ER-086526 mesylate,E7389 mesylate |
Apoptosis
,
Others
,
Microtubule Associated
|
|
Eribulin mesylate (E7389 mesylate) (E7389 mesylate) inhibits the proliferation of cancer cells by binding microtubule proteins and microtubules. Eribulin mesylate (E7389 mesylate) is a microtubule targeting agent that is... |
|
T3533 |
Apilimod mesylate
|
STA 5326 mesylate |
IL Receptor
,
PI3K
,
Interleukin
|
|
Apilimod mesylate (STA 5326 mesylate) is a potent IL-12/IL-23 inhibitor. |
|
T11043 |
Dihydroergocristine mesylate
|
DHEC (mesylate) |
Beta Amyloid
|
|
Dihydroergocristine mesylate (DHEC (mesylate))(DHEC mesylate) is the methanesulfonic acid salt of dihydroergocristine. It has been used as the for the symptomatic treatment of mental deterioration associated with cerebro... |
|
T0101 |
Doxazosin mesylate
|
UK 33274 mesylate |
Mitophagy
,
Adrenergic Receptor
,
Autophagy
|
|
Doxazosin mesylate (UK 33274 mesylate)(UK 33274) is a quinazoline-derivative. It is a selectively antagonizes postsynaptic α1-adrenergic receptors. |
|
T2545 |
Lomitapide Mesylate
|
BMS-201038 mesylate,AEGR-733 mesylate |
CETP
|
|
Lomitapide Mesylate (BMS-201038 mesylate) is a methanesulfonic acid form of lomitapide, a small molecule inhibitor of microsomal triglyceride transfer protein. |
|
T28978 |
Tirilazad mesylate
|
U-74006 mesylate,U74006 mesylate,U 74006 mesylate,U 74006F mesylate,U-74006F mesylate,U74006F mesylate |
Antiviral
|
|
Tirilazad mesylate (U 74006F) is a non-glucocorticoid, lipid peroxidation inhibitor with antiviral activity and neuroprotective activity.Tirilazad mesylate confines intracellular intramembranous foci, attenuates spinal c... |
|
T71699 |
Lanopepden mesylate
|
GSK 1322322 mesylate,GSK-1322322J mesylate |
Antibacterial
|
|
Lanopepden mesylate is a peptide deformylase inhibitor against Staphylococcus aureus. |
|
T6835 |
Fenoldopam mesylate
|
Fenoldopam methanesulfonate,SKF-82526 mesylate,Corlopam mesylate,mesylate,SKF 82526 |
Dopamine Receptor
|
|
Fenoldopam mesylate (Corlopam mesylate) is a selective dopamine-1 receptor (DA1) agonist with natriuretic/diuretic properties. It lowers blood pressure through arteriolar vasodilation. |
|
T3634 |
Osimertinib mesylate
|
Mereletinib mesylate,AZD-9291 mesylate |
EGFR
|
|
Osimertinib mesylate (Mereletinib mesylate) is an irreversible and mutant selective EGFR inhibitor (IC50s: 12/1 nM for EGFR(L858R) and EGFR(L858R/T790M)). |
|
T2190 |
Methiothepin mesylate
|
Ro 8-6837 mesylate,Metitepine mesylate |
Dopamine Receptor
,
5-HT Receptor
|
|
Methiothepin mesylate (Metitepine mesylate) is a potent and non-selective 5-HT2 receptor antagonist, used as an antipsychotic. |
|
T7175 |
Alflutinib mesylate
|
AST2818 mesylate |
EGFR
|
|
Alflutinib mesylate (AST2818 mesylate) ,is an irreversible tyrosine kinase inhibitor that selectively inhibits EGFR mutations, especially T790M. |
|
T7003 |
Leucomethylene blue mesylate
|
TRx0237 mesylate,TRx0237 (LMTX) mesylate,Methylene blue leuco base mesylate salt,Leucomethylene Blue Dimesylate |
Beta Amyloid
,
Microtubule Associated
|
|
Leucomethylene blue mesylate (TRx0237 mesylate) is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia. |
|
T1336 |
Benztropine mesylate
|
Benzotropine mesylate,Benzatropine mesylate,Benztropine methanesulfonate |
Dopamine Receptor
,
AChR
,
Histamine Receptor
|
|
Benztropine mesylate (Benztropine methanesulfonate) is a centrally active muscarinic antagonist that has been used in the symptomatic treatment of PARKINSON DISEASE. Benztropine also inhibits the uptake of dopamine. |
|
T6963 |
Reboxetine mesylate
|
FCE20124 mesylate,Edronax,PNU155950E mesylate,PNU 155950E |
Adrenergic Receptor
,
Norepinephrine
|
|
Reboxetine mesylate (FCE20124 mesylate) is a norepinephrine reuptake inhibitor (Ki: 8.2 nM). |
|
T7861 |
Flumatinib mesylate
|
HHGV678 mesylate |
Bcr-Abl
,
PDGFR
,
c-Kit
|
|
Flumatinib mesylate (HHGV678 mesylate) is a selective inhibitor of c-Abl, PDGFRβ and c-Kit, effectively overcomes drug resistance of certain KIT mutants. |
|
T8541 |
Lenvatinib mesylate
|
E7080 (mesylate) |
VEGFR
,
FGFR
,
c-RET
,
PDGFR
,
c-Kit
|
|
Lenvatinib mesylate (E7080 (mesylate)) is an oral and multi-targeted inhibitor of VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, with potent antitumor activities. |
|
T8544 |
Masitinib mesylate
|
AB-1010 mesylate |
Apoptosis
,
FAK
,
FGFR
,
PDGFR
,
Src
,
c-Kit
|
|
Masitinib mesylate (AB-1010 mesylate) is a selective and orally bioavailable c-Kit inhibitor (IC50 of 200 nM,540/800 nM,510 nM for human recombinant c-Kit;PDGFRα/β;LynB,respectively). |
|
T7804 |
Garenoxacin mesylate hydrate
|
Garenoxacin mesylate [USAN],BMS284756 (Mesylate hydrate) |
Antibacterial
|
|
Garenoxacin mesylate hydrate (Garenoxacin mesylate [USAN]) with potent antimicrobial activity, against common respiratory pathogens, including resistant strains. |
|
T8474 |
Dabrafenib Mesylate
|
GSK 2118436B,GSK2118436 Mesylate |
Raf
|
|
Dabrafenib Mesylate (GSK2118436 Mesylate) is a B-Raf inhibitor(IC50s of 0.6 and 5.0 nM for RafV600E and c-Raf, respectively). |
|
T1621 |
Imatinib Mesylate
|
ST-1571 Mesylate,STI-571,CGP-57148B |
Bcr-Abl
,
PDGFR
,
c-Kit
,
Autophagy
|
|
Imatinib Mesylate (STI-571) is a tyrosine kinase receptor inhibitor with antineoplastic activity (IC50s: 0.6 μM, 0.1 μM and 0.1 μM for v-Abl, c-Kit and PDGFR, respectively). |
|
T26834 |
BL-1020 Mesylate
|
CYP-1020 Mesylate |
Dopamine Receptor
,
GABA Receptor
|
|
BL-1020 Mesylate (CYP-1020 Mesylate) is an orally available GABA A receptor agonist and D2 antagonist that decreases dopamine activity and enhances GABAA activity.BL-1020 Mesylate has been used in the study of schizophre... |
|
T1492 |
Gemifloxacin mesylate
|
LB-20304a,SB-265805S,Gemifloxacin mesylate |
DNA gyrase
,
Topoisomerase
,
Antibacterial
|
|
Gemifloxacin mesylate (Gemifloxacin mesylate) inhibits activities of DNA gyrase and topoisomerase IV, thereby inhibiting DNA replication and eventually bacterial growth. Gemifloxacin Mesylate is the mesylate salt form of... |
|
T19526 |
Pradefovir mesylate
|
Pradefovir mesilate,Remofovir mesylate,Hepavir B |
P450
|
|
Pradefovir mesylate (Hepavir B) is converted to 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in human liver microsomes with Km of 60 μM. |
|
T2589 |
Dolasetron Mesylate hydrate
|
Dalasetron Mesylate Hydrate |
5-HT Receptor
|
|
Dolasetron Mesylate hydrate (Dalasetron Mesylate Hydrate) , a selective serotonin receptor antagonist, competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemotherapy- and radioth... |
|
T23588 |
9-CP-Ade Mesylate
|
9-Cyclopentyladenine monomethanesulfonate,9 CP Ade Mesylate,9CPAde Mesylate |
AChR
|
|
9-CP-Ade Mesylate (9 CP Ade Mesylate) is a cell-permeable, stable and non-competitive inhibitor of adenylate cyclase. |
|
T6001 |
Nelfinavir Mesylate
|
Viracept,Nelfin,AG1343,AG 1343 Mesylate |
HIV Protease
|
|
Nelfinavir Mesylate (Viracept) is an effective HIV protease inhibitor (Ki: 2 nM). |
|
T23453 |
Tetrindole mesylate
|
|
MAO
|
|
Tetrindole mesylate is a MAO-A inhibitor. |
|
T0425L |
Pefloxacin Mesylate Dihydrate
|
Pefloxacinium mesylate dihydrate,1589 RB |
Topoisomerase
,
Antibacterial
,
Antibiotic
|
|
Pefloxacin Mesylate Dihydrate (1589 RB) , an antibacterial agent, restrains bacterial DNA replication by inhibiting DNA gyrase (topoisomerase). |
|
T6643 |
Ro 31-8220 Mesylate
|
Ro 31-8220 methanesulfonate,Bisindolylmaleimide IX,Bisindolylmaleimide IX mesylate |
PKC
|
|
Ro 31-8220 Mesylate (Bisindolylmaleimide IX mesylate) is a pan-PKC inhibitor for PKC-α/βI/βII/γ/ε (IC50: 5/24/14/27/24 nM), and also shows potent inhibition against MSK1, MAPKAP-K1b, S6K1, and GSK3β. |
|
T2226 |
Pergolide mesylate
|
Pergolide mesylate salt,LY127809,Pergolide methanesulfonate |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
|
|
Pergolide mesylate salt(LY127809) is a long-acting dopamine agonist which has been used to treat PARKINSON DISEASE and HYPERPROLACTINEMIA but withdrawn from some markets due to potential for HEART VALVE DISEASES. |
|
T10759 |
CEP-28122 mesylate salt (1022958-60-6 free base)
|
CEP-28122 mesylate salt |
ALK
|
|
CEP-28122 mesylate salt (1022958-60-6 free base) is a highly selective orally active ALK inhibitor (IC50: 1.9 nM in an enzyme-based TRF assay). |
|
T1637 |
Deferoxamine Mesylate
|
desferrioxamine B,Desferrioxamine B mesylate,DFO,DFOM |
Mitophagy
,
Beta Amyloid
,
Others
,
Ferroptosis
,
HIF/HIF Prolyl-Hydroxylase
,
Autophagy
|
|
Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor. Deferoxamine Mesylate binds free iron into a stable complex and reduces iron accumulation. Deferoxamine Mesylate up-regulates HIF-1α levels and i... |
|
T6983 |
Sildenafil Mesylate
|
|
PDE
|
|
Sildenafil Mesylate is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5. |
|
T6651 |
Safinamide mesylate
|
PNU-151774E,FCE28073,PNU-151774E,NW-1015,EMD 1195686 mesylate |
MAO
,
Monoamine Oxidase
|
|
Safinamide mesylate (EMD 1195686 mesylate) , a mesylate salt of Safinamide, can reversibly and specifically inhibit MAO-B (IC50: 98 nM), has 5918-fold selectivity against MAO-A. |
|
T9173 |
HM-30181 mesylate monohydrate
|
|
P-gp
|
|
HM-30181 mesylate monohydrate is an oral P-glycoprotein (P-gp) inhibitor, used to enhance the oral bioavailability of P-gp substrate drugs. |
|
T9865 |
Almonertinib mesylate
|
|
EGFR
|
|
Almonertinib mesylate is an irreversible inhibitor of EGFR tyrosine kinase with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib mesylate can be used in the non-small cell lung cancer st... |
|
T10432L |
AZD-8529 mesylate
|
|
GluR
|
|
AZD-8529 mesylate is a highly selective, and orally bioavailable positive allosteric modulator of mGluR2 (EC50: 285 nM). It shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 ... |
|
T2617 |
SNS-314 Mesylate
|
SNS-314 |
Aurora Kinase
|
|
SNS-314 Mesylate (SNS-314) is an effective and specific Aurora A/B/C inhibitor (IC50: 9/31/3 nM). It is less inhibition of Trk A/B, Fms, Flt4, c-Raf, Axl, and DDR2. |
|
T4042 |
Talabostat mesylate
|
Val-boroPro,PT100 |
Proteasome
,
DPP-4
|
|
Talabostat mesylate (PT100) is an orally active, selective inhibitor of dipeptidyl peptidases IV (DPP4, IC50: 0.18 nM), including tumor-associated fibroblast activation protein. This agent may also stimulate the producti... |
|
T41194 |
FFN 102 mesylate
|
|
Others
|
|
FFN 102 mesylate is a pH responsive fluorescent false neurotransmitter (FFN), a selective dopamine transporter (DAT) and VMAT2 substrate. Exhibits no significant binding to a panel of 38 CNS receptors, including dopamine... |
|
T0372 |
Gabexate mesylate
|
FOY |
Factor Xa
,
Serine Protease
,
Proteasome
|
|
Gabexate mesylate (FOY) is a serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a regional anticoagulant for hemodialysis. The drug inh... |
