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Search Results for " hypoxia-inducible "

ターゲット

HIF/HIF Prolyl-Hydroxylase HIF

66

阻害剤

25

天然化合物

6

リコンビナントタンパク質

1

ライブラリー

カタログ番号 製品名 別名 ターゲット
T3169 KC7F2 HIF/HIF Prolyl-Hydroxylase , HIF
KC7F2 is a potent HIF-1 pathway inhibitor with potential anti-cancer activity.
T22022 Adaptaquin HIF
Adaptaquin is an inhibitor of the hypoxia-inducing factor prolyl hydroxylase (HIF-PH) [1] [2].
T0244 Tilorone dihydrochloride Influenza Virus , HIF/HIF Prolyl-Hydroxylase , IFNAR
Tilorone dihydrochloride is an orally active interferon inducer, and has antineoplastic and anti-inflammatory actions.
T13398 ZINC13466751 HIF
ZINC13466751 is a potent HIF-1α/von Hippel-Lindau interaction inhibitor(IC50 of 2.0 µM).
T5392 TP0463518 HIF/HIF Prolyl-Hydroxylase
TP-0463518 is a highly potent HIF prolyl hydroxylase (PHD) inhibitor (IC50s: 13 nM and 18 nM for human and rat PHD2, respectively).
T7880 IOX4 HIF/HIF Prolyl-Hydroxylase
IOX4 is a potent PHD2 inhibitor (IC50 = 1.6 nM)
T7848 PT-2385 HIF/HIF Prolyl-Hydroxylase , HIF
PT-2385 is a selective HIF-2α inhibitor (Kd<50 nM).
T5537 IDF-11774 HIF/HIF Prolyl-Hydroxylase , HIF
IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM).
T12675L PT2399 HIF/HIF Prolyl-Hydroxylase , HIF
PT2399 shows effective antitumor activity in vivo. PT2399 is an effective and selective HIF-2α antagonist, which directly binds to the HIF-2α PAS B domain (IC50: 6 nM).
T13050 SYP-5 HIF/HIF Prolyl-Hydroxylase , HIF
SYP-5 is a novel inhibitor of HIF-1, suppresses tumor cells invasion and angiogenesis.
T50099 HIF-2α-IN-4 Others , HIF/HIF Prolyl-Hydroxylase
HIF-2a translation inhibitor is a compound used as a molecular building block.
T4106 MK-8617 MK8617 HIF/HIF Prolyl-Hydroxylase
MK-8617 is an orally available HIF PHD1 3 pan-inhibitor, inhibiting PHD1/2/3 (IC50: 1.0/1.0/14 nM).
T2488 BAY 87-2243 Ferroptosis , HIF/HIF Prolyl-Hydroxylase , HIF
BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).
T15219 Enarodustat JTZ-951 Others , HIF/HIF Prolyl-Hydroxylase
Enarodustat (JTZ-951) is an orally active factor inhibitor of prolyl hydroxylase (EC50: 0.22 μM) and has the potential for renal anemia treatment.
T21653 1,4-DPCA HIF/HIF Prolyl-Hydroxylase
1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibiting HIF (FIH).
T64336 Izilendustat HIF/HIF Prolyl-Hydroxylase
Tert-butyl 4-[[1-[(4-chlorophenyl)methyl]-3-hydroxy-2-oxopyridin-4-yl]methyl]piperazine-1-carboxylate inhibit of human recombinant EGLN-1 as substrate after 20 mins by mass spectrophotometric analysis.
T7802 M1001 HIF/HIF Prolyl-Hydroxylase , HIF
M1001 is a HIF-2α agonist.
T11561 HIF-2α-IN-2 HIF/HIF Prolyl-Hydroxylase , HIF
HIF-2α-IN-2 is a hypoxia-inducible factor (HIF-2α) inhibitor (IC50: 16 nM in scintillation proximity assay).
T29797 AKB-6899 AKB6899 VEGFR , HIF/HIF Prolyl-Hydroxylase , HIF
AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macrophages. AKB-6899 leads to stabilization of HIF-2α which in...
T21806 HNHA HDAC
HNHA is an inhibitor of HDAC.
T1823 IOX2 IOX 2,JICL38 HIF/HIF Prolyl-Hydroxylase
IOX2 (IOX 2) is a selective inhibitor of the Hypoxia Inducible Factor (HIF) Prolyl-Hydroxylases (PHD); active in cells with the IC50 value of 21 nM for PHD2/ELGN-1 and no inhibition at FIH (20uM).
T9627 PHD-1-IN-1 HIF/HIF Prolyl-Hydroxylase
PHD-1-IN-1 is a potent inhibitor of hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) enzyme(IC50 = 0.034 μM).
T6961 PX-478 PX-478 2HCl HIF/HIF Prolyl-Hydroxylase , HIF , Autophagy
PX-478 is a HIF-1α inhibitor with selectivity, oral activity, and blood-brain barrier permeability. PX-478 has antitumor activity and also protects pancreatic β-cell function in diabetes mellitus and is used in type 2 di...
T3180 JNJ-42041935 HIF-PHD Inhibitor II HIF/HIF Prolyl-Hydroxylase
JNJ-42041935 (HIF-PHD Inhibitor II) is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes.
T1613 Hydralazine hydrochloride Hydralazine HCl,Apresoline MAO , HIF/HIF Prolyl-Hydroxylase
Hydralazine hydrochloride (Apresoline) is the hydrochloride salt of hydralazine, a phthalazine derivative with antihypertensive and potential antineoplastic activities. Hydralazine alters intracellular calcium release an...
T13289 EHP-101 VCE-​004.8 Cannabinoid Receptor , HIF/HIF Prolyl-Hydroxylase , PPAR
EHP-101 (VCE-004.8) is a specific dual agonist of PPARγ and CB2 receptor with potent anti-inflammatory activity. EHP-101 attenuates adipogenesis and prevents diet-induced obesity.
T16679 Belzutifan PT2977,MK-6482 HIF
Belzutifan (MK-6482) is a potential treatment for clear cell renal cell carcinoma (ccRCC). Belzutifan is an orally active and selective HIF-2α inhibitor (IC50: 9 nM). Belzutifan , as a second-generation HIF-2α inhibitor,...
T15396 GN44028 N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine HIF
GN44028 (N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine) is a hypoxia-inducible factor inhibitor of (HIF)-1 (IC50: 14 nM). GN44028 inhibits hypoxia-induced HIF-1α transcriptional activity. H...
T9890 HIF1-IN-3  Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]- HIF
HIF1-IN-3 (Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]-) is an effective inhibitor of HIF-1 (EC50 = 0.9 μM) and can be used in anticancer studies.
T1939 DMOG Dimethyloxalylglycine,Dimethyloxallyl Glycine,Dimethyloxaloylglycine HIF/HIF Prolyl-Hydroxylase , HIF , Autophagy
DMOG (Dimethyloxalylglycine), an antagonist of the α-ketoglutarate cofactor, is an inhibitor for HIF prolyl hydroxylase.
T2445 FG-2216 YM-311,FG2216,FG 2216 HIF/HIF Prolyl-Hydroxylase
FG-2216 (YM-311) is a potent HIF-prolyl hydroxylase inhibitor for the PDH2 enzyme (IC50: 3.9 uM); orally bioavailable and induced reversible and significant Epo induction in vivo.
T3289 Amifostine Ethyol,WR2721,Gammaphos Others , HIF/HIF Prolyl-Hydroxylase
Amifostine (Ethyol) anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.
T0153 Oltipraz NSC 347901,RP 35972 HIF/HIF Prolyl-Hydroxylase , HIV Protease , Reverse Transcriptase , Nrf2 , HIF
Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes, such as glutathione S transferase (GST) and NAD(P)H: quin...
T6381 Amifostine trihydrate Ethyol trihydrate,WR2721,Amifostine Others , HIF/HIF Prolyl-Hydroxylase
Amifostine trihydrate (WR2721) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.
T3494 LW6 HIF-1α inhibitor,CAY10585,LW8 Apoptosis , Dehydrogenase , HIF/HIF Prolyl-Hydroxylase , HIF
LW6 (HIF-1α inhibitor) is a novel HIF-1 inhibitor.
T1101 Minocycline hydrochloride Minocycline HCl HIF/HIF Prolyl-Hydroxylase , Antibacterial , Antibiotic
Minocycline hydrochloride (Minocycline HCl) is a tetracycline antibiotic with excellent absorption and tissue penetration that is used for several bacterial infections as well as treatment of acne. Minocycline hydrochlor...
T1637 Deferoxamine Mesylate desferrioxamine B,Desferrioxamine B mesylate,DFO,DFOM Mitophagy , Beta Amyloid , Others , Ferroptosis , HIF/HIF Prolyl-Hydroxylase , Autophagy
Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor. Deferoxamine Mesylate binds free iron into a stable complex and reduces iron accumulation. Deferoxamine Mesylate up-regulates HIF-1α levels and i...
T6823 E3330 HIF/HIF Prolyl-Hydroxylase , DNA/RNA Synthesis
E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.
T6804 Chetomin Chaetomin,NSC289491,BRN0077366 Apoptosis , HSP , HIF
Chetomin (BRN0077366) is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar concentrations.
T36711 FM19G11 FM19G11,HIF-1alpha/2alpha Inhibitor HIF
FM19G11 is an inhibitor of hypoxia inducible factor (HIF) α-subunit (IC50 = 80 nM in hypoxia induced luciferase assay).
T7836 ML228 HIF
ML228 is a potent the Hypoxia Inducible Factor (HIF) pathway activator with EC50 of 1 μM. ML228 potently activates HIF in vitro as well as its downstream target VEGF.
T4381 Lificiguat YC-1 Others , Guanylate cyclase , HIF
Lificiguat (YC-1) is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha).
T9088 Topovale ARC111,ARC 111,ARC-111,Topoval Topoisomerase
Topovale (ARC111) is a potent inhibitor of topoisomerase I. Topovale inhibits hypoxia-mediated accumulation of hypoxia-inducible factor-1alpha. Topovale exhibited low nM cytotoxicity against a panel of cancer cells. Topo...
T61822 M1002 HIF
M1002 is a hypoxia-inducible factor-2 (HIF-2) agonist that enhances the affinity of HIF-2alpha and ARNT for transcriptional activation.M1002 alters the Tyr2 conformation of the HIF-281alpha PAS-B structural domain and ac...
T23894 CLB-016
CLB-016 is an inhibitor of hypoxia-inducible factor (HIF)-1.
T27699 JTZ-951 HCl JTZ-951,JTZ 951 hydrochloride,JTZ951 HCl,JTZ 951
JTZ-951 is a potent and orally active inhibitor of hypoxia inducible factor prolyl hydroxylase (PHD).
T12547 Prolyl Hydroxylase inhibitor 1 Others
Prolyl Hydroxylase inhibitor 1 is an orally active inhibitor of hypoxia inducible factor (HIF)-prolyl hydroxylase (PHD) (IC50 of 62.23 nM).
T12675 (Rac)-PT2399 HIF
(Rac)-PT2399 is a potent and specific inhibitor of hypoxia-inducible factor 2a (HIF-2α)(IC50 of 0.01 μM).
T38693 TRC160334 TRC160334
TRC160334 is a hydroxylase inhibitor of hypoxia-inducible factor (HIF). It is employed in research about ischemia/reperfusion injury.
T25255 CL67 CL-67,CL 67
CL67 is a hypoxia-inducible factor pathway inhibitor. It acts by binding to a G-quadruplex higher-order structure in the HIF promoter sequence in vitro.

Compounds

KC7F2
T3169
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase, HIF
Adaptaquin
T22022
Synonym:
Target: HIF
Tilorone dihydrochloride
T0244
Synonym:
Target: Influenza Virus, HIF/HIF Prolyl-Hydroxylase, IFNAR
ZINC13466751
T13398
Synonym:
Target: HIF
TP0463518
T5392
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase
IOX4
T7880
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase
PT-2385
T7848
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase, HIF
IDF-11774
T5537
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase, HIF
PT2399
T12675L
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase, HIF
SYP-5
T13050
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase, HIF
HIF-2α-IN-4
T50099
Synonym:
Target: Others, HIF/HIF Prolyl-Hydroxylase
MK-8617
T4106
Synonym: MK8617
Target: HIF/HIF Prolyl-Hydroxylase
BAY 87-2243
T2488
Synonym:
Target: Ferroptosis, HIF/HIF Prolyl-Hydroxylase, HIF
Enarodustat
T15219
Synonym: JTZ-951
Target: Others, HIF/HIF Prolyl-Hydroxylase
1,4-DPCA
T21653
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase
Izilendustat
T64336
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase
M1001
T7802
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase, HIF
HIF-2α-IN-2
T11561
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase, HIF
AKB-6899
T29797
Synonym: AKB6899
Target: VEGFR, HIF/HIF Prolyl-Hydroxylase, HIF
HNHA
T21806
Synonym:
Target: HDAC
IOX2
T1823
Synonym: IOX 2,JICL38
Target: HIF/HIF Prolyl-Hydroxylase
PHD-1-IN-1
T9627
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase
PX-478
T6961
Synonym: PX-478 2HCl
Target: HIF/HIF Prolyl-Hydroxylase, HIF, Autophagy
JNJ-42041935
T3180
Synonym: HIF-PHD Inhibitor II
Target: HIF/HIF Prolyl-Hydroxylase
Hydralazine hydrochloride
T1613
Synonym: Hydralazine HCl,Apresoline
Target: MAO, HIF/HIF Prolyl-Hydroxylase
EHP-101
T13289
Synonym: VCE-​004.8
Target: Cannabinoid Receptor, HIF/HIF Prolyl-Hydroxylase, PPAR
Belzutifan
T16679
Synonym: PT2977,MK-6482
Target: HIF
GN44028
T15396
Synonym: N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine
Target: HIF
HIF1-IN-3 
T9890
Synonym: Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]-
Target: HIF
DMOG
T1939
Synonym: Dimethyloxalylglycine,Dimethyloxallyl Glycine,Dimethyloxaloylglycine
Target: HIF/HIF Prolyl-Hydroxylase, HIF, Autophagy
FG-2216
T2445
Synonym: YM-311,FG2216,FG 2216
Target: HIF/HIF Prolyl-Hydroxylase
Amifostine
T3289
Synonym: Ethyol,WR2721,Gammaphos
Target: Others, HIF/HIF Prolyl-Hydroxylase
Oltipraz
T0153
Synonym: NSC 347901,RP 35972
Target: HIF/HIF Prolyl-Hydroxylase, HIV Protease, Reverse Transcriptase, Nrf2, HIF
Amifostine trihydrate
T6381
Synonym: Ethyol trihydrate,WR2721,Amifostine
Target: Others, HIF/HIF Prolyl-Hydroxylase
LW6
T3494
Synonym: HIF-1α inhibitor,CAY10585,LW8
Target: Apoptosis, Dehydrogenase, HIF/HIF Prolyl-Hydroxylase, HIF
Minocycline hydrochloride
T1101
Synonym: Minocycline HCl
Target: HIF/HIF Prolyl-Hydroxylase, Antibacterial, Antibiotic
Deferoxamine Mesylate
T1637
Synonym: desferrioxamine B,Desferrioxamine B mesylate,DFO,DFOM
Target: Mitophagy, Beta Amyloid, Others, Ferroptosis, HIF/HIF Prolyl-Hydroxylase, Autophagy
E3330
T6823
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase, DNA/RNA Synthesis
Chetomin
T6804
Synonym: Chaetomin,NSC289491,BRN0077366
Target: Apoptosis, HSP, HIF
FM19G11
T36711
Synonym: FM19G11,HIF-1alpha/2alpha Inhibitor
Target: HIF
ML228
T7836
Synonym:
Target: HIF
Lificiguat
T4381
Synonym: YC-1
Target: Others, Guanylate cyclase, HIF
Topovale
T9088
Synonym: ARC111,ARC 111,ARC-111,Topoval
Target: Topoisomerase
M1002
T61822
Synonym:
Target: HIF
CLB-016
T23894
Synonym:
Target:
JTZ-951 HCl
T27699
Synonym: JTZ-951,JTZ 951 hydrochloride,JTZ951 HCl,JTZ 951
Target:
Prolyl Hydroxylase inhibitor 1
T12547
Synonym:
Target: Others
(Rac)-PT2399
T12675
Synonym:
Target: HIF
TRC160334
T38693
Synonym: TRC160334
Target:
CL67
T25255
Synonym: CL-67,CL 67
Target:
1 2
カタログ番号 製品名 別名 ターゲット
T6S0071 Fraxinellone HIF/HIF Prolyl-Hydroxylase , STAT , PD-1/PD-L1
1. Fraxinellone significantly reduced weight loss and diarrhea in mice and alleviated the macroscopic and microscopic signs of the disease. 2. Fraxinellone exhibited a variety of insecticidal activities including feeding...
T5S2347 Deoxyshikonin Arnebin 7 Others , HIF/HIF Prolyl-Hydroxylase , Antibacterial
1. Deoxyshikonin (Arnebin 7) may be a new drug candidate for wound healing and treatment of lymphatic diseases. 2. Deoxyshikonin enhances the ability of human dermal lymphatic microvascular endothelial cells (HMVEC-dLy) ...
TL0001 Dencichine L-Dencichin,ODAP,Dencichin Others , HIF/HIF Prolyl-Hydroxylase
Dencichine (ODAP) is a neurotoxic agent. Dencichine is a haemostatic agent, the hemostatic effect relates to modulation of the coagulation system, platelet aggregation and fibrinolytic system. It has renoprotective effec...
T0429 Glucosamine Chitosamine,D-Glucosamine MMP , Others , TNF , NF-κB , Reactive Oxygen Species , HIF/HIF Prolyl-Hydroxylase , Endogenous Metabolite , CFTR , Autophagy
Glucosamine (Chitosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to rebuild cartilage and treat arthritis.
T2763 Panaxadiol 20(R)-Panaxadiol Others , HIF/HIF Prolyl-Hydroxylase
Panaxadiol (20(R)-Panaxadiol) is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng.
T6S1315 Oroxylin A 6-Methoxybaicalein,Baicalein 6-methyl ether Virus Protease , HIF/HIF Prolyl-Hydroxylase , Autophagy
1. Oroxylin A (Baicalein 6-methyl ether) has various anti-tumor effects including apoptosis, cell cycle arrest, drug-resistant reversion. 2. Oroxylin A possesses abilities of inhibiting the ATRA-induced IL-6 production v...
T5684 Ethyl 3,4-dihydroxybenzoate Apoptosis , Others , Reactive Oxygen Species , HIF/HIF Prolyl-Hydroxylase , NO Synthase , Autophagy
Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.
T2792 Glucosamine sulfate D-Glucosamine sulphate,D-Glucosaminesulfate MMP , Reactive Oxygen Species , HIF/HIF Prolyl-Hydroxylase , Endogenous Metabolite , Autophagy
Glucosamine sulfate (D-Glucosaminesulfate) was extracted from synthetic product;Store the product in sealed, cool and dry condition.
T1152 Albendazole SKF-62979 HIF/HIF Prolyl-Hydroxylase , Microtubule Associated , Antibiotic , Parasite
Albendazole (SKF-62979) is used as a drug indicated for the treatment of a variety of worm infestations.
T2805 Chlorogenic Acid NSC-407296,3-O-Caffeoylquinic acid,Heriguard Others , Influenza Virus , Reactive Oxygen Species , HIF/HIF Prolyl-Hydroxylase , Endogenous Metabolite , Antibacterial
Chlorogenic Acid (NSC-407296) is a naturally occurring phenolic acid which is a carcinogenic inhibitor. It has also been shown to prevent paraquat-induced oxidative stress in rats.
T1205 Chloramphenicol Chlornitromycin,Levomycetin,Chloromycetin ribosome , HIF/HIF Prolyl-Hydroxylase , Antibacterial , Antibiotic
Chloramphenicol (Chloromycetin), a broad-spectrum antibiotic, blocks bacterial protein synthesis.
T11589 Hydroxycitric acid tripotassium hydrate Potassium citrate monohydrate ATP Citrate Lyase , HIF/HIF Prolyl-Hydroxylase , HIF
Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) effectively inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation, and anti-tumor effects. Hydroxycitric acid tr...
T2941 Glucosamine hydrochloride Chitosamine hydrochloride,2-Amino-2-deoxy-glucose HCl,Chitosamine HCl,D-(+)-Glucosamine hydrochloride Reactive Oxygen Species , HIF/HIF Prolyl-Hydroxylase , Endogenous Metabolite , Autophagy
Glucosamine hydrochloride (Chitosamine hydrochloride) is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.
T0256 Citric acid trilithium salt tetrahydrate Lithium citrate tribasic tetrahydrate,Trilithium citrate tetrahydrate Dehydrogenase , GSK-3 , HIF/HIF Prolyl-Hydroxylase , Antibacterial , GluR
Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) , the active component of Lithium, is a medicine used in the therapy of psychiatric disease. It has shown the effects of signaling pathways...
T5S1569 AKBA 3-O-Acetyl-11-keto-β-boswellic acid,3-O-Acetyl-11-keto-beta-boswellic acid,Acetyl-11-keto-β-boswellic acid Others , Reactive Oxygen Species , HIF/HIF Prolyl-Hydroxylase , Endogenous Metabolite
AKBA (3-O-Acetyl-11-keto-beta-boswellic acid), a natural component from frankincense, is a novel activator of Nrf2.
T10233 Acetylarenobufagin HIF
Acetylarenobufagin is a steroidal hypoxia-inducible factor-1 (HIF-1) modulator.
TN1916 Matairesinol ATPase , p38 MAPK , ROS
Matairesinol has radical and superoxide scavenging activities,; it also has anti-angiogenic activity by suppressing mROS signaling , can decrease hypoxia-inducible factor-1α± in hypoxic HeLa cells.
T4S0800 Demethyleneberberine P450 , NOS , NF-κB , HIF , AMPK
Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria either in vitro or in vivo.Demethyleneberberine suppresses CYP2E1,...
TWS1977 Kamebakaurin Kamebakaurine NF-κB
1. Kamebakaurin (Kamebakaurine) has the ability to protect the liver from APAP-induced hepatotoxicity, presumably by both inhibiting the inflammatory response and oxidative stress. 2. Kamebakaurin inhibits the expression...
T6429 Caffeic Acid Phenethyl Ester Phenylethyl Caffeate,CAPE Apoptosis , NF-κB
Caffeic Acid Phenethyl Ester (Phenylethyl Caffeate) (CAPE) inhibits the activation of nuclear transcription factor NF-kappa B and may suppress p70S6K and Akt-driven signaling pathways, with antineoplastic, cytoprotective...
T6569L Mimocine Mimocine
Mimosine, a plant amino acid, is known to act as a normoxic inducer of hypoxia-inducible factor (HIF).
TN1952 Moracin P Others , ROS , HIF
Moracin P exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1), which is a key mediator during adaptation of cancer cells to tumour hypoxia.
TN1951 Moracin O HIF
Moracin O shows significant neuroprotective, and analgesic activities, it also has a strong protective influence against doxorubicin-induced cardiomyopathy in H9c2 cells with the EC50 value of 4.5 ± 1.3 μM. Moracin O exh...
T75487 7-Hydroxyneolamellarin A
7-Hydroxyneolamellarin A, a natural product from the sponge Dendrilla nigra, serves as a potent inhibitor of hypoxia-inducible factor-1α (HIF-1α). It effectively reduces the accumulation of HIF-1α protein and suppresses ...
T36439 Gramicidin A Antibacterial , HIF , Parasite
Gramicidin A is a peptide antibiotic isolated from B. brevis.Gramicidin A is a highly hydrophobic channel-forming ion carrier that forms monovalent cation-permeable channels in artificial membranes.Gramicidin A induces t...

天然物製品

Fraxinellone
T6S0071
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase, STAT, PD-1/PD-L1
Deoxyshikonin
T5S2347
Synonym: Arnebin 7
Target: Others, HIF/HIF Prolyl-Hydroxylase, Antibacterial
dencichine
TL0001
Synonym: L-Dencichin,ODAP,Dencichin
Target: Others, HIF/HIF Prolyl-Hydroxylase
Glucosamine
T0429
Synonym: Chitosamine,D-Glucosamine
Target: MMP, Others, TNF, NF-κB, Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, Endogenous Metabolite, CFTR, Autophagy
Panaxadiol
T2763
Synonym: 20(R)-Panaxadiol
Target: Others, HIF/HIF Prolyl-Hydroxylase
Oroxylin A
T6S1315
Synonym: 6-Methoxybaicalein,Baicalein 6-methyl ether
Target: Virus Protease, HIF/HIF Prolyl-Hydroxylase, Autophagy
Ethyl 3,4-dihydroxybenzoate
T5684
Synonym:
Target: Apoptosis, Others, Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, NO Synthase, Autophagy
Glucosamine sulfate
T2792
Synonym: D-Glucosamine sulphate,D-Glucosaminesulfate
Target: MMP, Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, Endogenous Metabolite, Autophagy
Albendazole
T1152
Synonym: SKF-62979
Target: HIF/HIF Prolyl-Hydroxylase, Microtubule Associated, Antibiotic, Parasite
Chlorogenic Acid
T2805
Synonym: NSC-407296,3-O-Caffeoylquinic acid,Heriguard
Target: Others, Influenza Virus, Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, Endogenous Metabolite, Antibacterial
Chloramphenicol
T1205
Synonym: Chlornitromycin,Levomycetin,Chloromycetin
Target: ribosome, HIF/HIF Prolyl-Hydroxylase, Antibacterial, Antibiotic
Hydroxycitric acid tripotassium hydrate
T11589
Synonym: Potassium citrate monohydrate
Target: ATP Citrate Lyase, HIF/HIF Prolyl-Hydroxylase, HIF
Glucosamine hydrochloride
T2941
Synonym: Chitosamine hydrochloride,2-Amino-2-deoxy-glucose HCl,Chitosamine HCl,D-(+)-Glucosamine hydrochloride
Target: Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, Endogenous Metabolite, Autophagy
Citric acid trilithium salt tetrahydrate
T0256
Synonym: Lithium citrate tribasic tetrahydrate,Trilithium citrate tetrahydrate
Target: Dehydrogenase, GSK-3, HIF/HIF Prolyl-Hydroxylase, Antibacterial, GluR
AKBA
T5S1569
Synonym: 3-O-Acetyl-11-keto-β-boswellic acid,3-O-Acetyl-11-keto-beta-boswellic acid,Acetyl-11-keto-β-boswellic acid
Target: Others, Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, Endogenous Metabolite
Acetylarenobufagin
T10233
Synonym:
Target: HIF
Matairesinol
TN1916
Synonym:
Target: ATPase, p38 MAPK, ROS
Demethyleneberberine
T4S0800
Synonym:
Target: P450, NOS, NF-κB, HIF, AMPK
Kamebakaurin
TWS1977
Synonym: Kamebakaurine
Target: NF-κB
Caffeic Acid Phenethyl Ester
T6429
Synonym: Phenylethyl Caffeate,CAPE
Target: Apoptosis, NF-κB
Mimocine
T6569L
Synonym: Mimocine
Target:
Moracin P
TN1952
Synonym:
Target: Others, ROS, HIF
Moracin O
TN1951
Synonym:
Target: HIF
7-Hydroxyneolamellarin A
T75487
Synonym:
Target:
Gramicidin A
T36439
Synonym:
Target: Antibacterial, HIF, Parasite

Recombinant Proteins

Species：
Human (6)
Expression System：
E. coli (4)
Baculovirus-Insect Cells (1)
Yeast (1)
Tag：
His (1)
His,GST (1)
N-GST (1)
N-terminal 10xHis-tagged and C-terminal Myc-tagged (1)
N-terminal 6xHis-SUMO-tagged (1)
N-terminal 6xHis-tagged (1)
カタログ番号 製品名 Species Expression System
TMPY-01709 HIF-1 alpha Protein, Human, Recombinant (His) Human E. coli
HIF-1 alpha, also known as HIF1A, contains 1 basic helix-loop-helix (bHLH) domain, 1 PAC (PAS-associated C-terminal) domain, and 2 PAS (PER-ARNT-SIM) domains. It is one of the two subunits of Hypoxia-inducible factor-1 (...
TMPH-00957 ARNT Protein, Human, Recombinant (His) Human Yeast
ARNT Protein, Human, Recombinant (His) is expressed in Yeast.
TMPH-02233 P4HTM Protein, Human, Recombinant (His & SUMO) Human E. coli
Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic...
TMPH-01280 EGLN1 Protein, Human, Recombinant (His & Myc) Human E. coli
Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of th...
TMPJ-00999 UBE2D1 Protein, Human, Recombinant (GST) Human E. coli
Ubiquitin-conjugating enzyme E2 D1（UBE2D1）belongs to the ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes...
TMPY-04474 PFKFB3 Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
Fructose-2,6-biphosphatase 3, also known as 6-phosphofructo-2-kinase or PFK2 or PFKFB3, is a potent activator of phosphofructokinase, which is a rate-limiting enzyme of glycolysis. Highly phosphorylated PFKFB3 protein wa...
カタログ番号 製品名
L8500 HIF-1 Signaling Pathway Compound Library

1336 compounds
A unique collection of 1336 HIF-1 related small chemicals can be used for drug discovery in ischemic disease and cancer and related mechanism studies；

ライブラリー

HIF-1 Signaling Pathway Compound Library
L8500
Compounds: 1336
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