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天然化合物

リコンビナントタンパク質

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カタログ番号	製品名	別名	ターゲット
T13865	Resorcinolnaphthalein		RAAS
	Resorcinolnaphthalein is a specific enhancer of angiotensin-converting enzyme 2 (ACE2) (EC50 value of 19.5 μM).		RAAS
T2320	Indacaterol		Adrenergic Receptor
	Indacaterol (Onbrez; Arcapta) is a β2-Adrenergic Agonist. The mechanism of action of indacaterol is as an Adrenergic beta2-Agonist.		Adrenergic Receptor
TP1563	Gap19		Gap Junction Protein
	Gap19 is a peptide that corresponds to a sequence on the cytoplasmic loop (CL) of Cx43.		Gap Junction Protein
T15108	DG-041		Prostaglandin Receptor
	DG-041 is an antagonist of high-affinity EP3 receptor (IC50s: 4.6 nM and 8.1 nM in the binding and FLIPR assay, respectively). DG-041 inhibits PGE2 facilitation of platelet aggregation and has the blood-brain barrier per...		Prostaglandin Receptor
T1265	Amrinone	Inamrinone,Inocor,Wincoram	TNF , PDE
	Amrinone (Inocor) is a positive inotropic cardiotonic (cardiotonic agent) with vasodilator properties, phosphodiesterase 3 inhibitory activity.		TNF , PDE
T23312	SB 204741		5-HT Receptor
	SB 204741 is a selective 5-HT2B antagonist with high affinity and pKi value of 7.1.		5-HT Receptor
T9765	TJ-M2010-5		MyD88
	TJ-M2010-5 is a MyD88 inhibitor that binds to the TIR domain to interfere with its homodimerization and suppress MyD88 signaling. TJ-M2010-5 can be used in myocardial ischemia/reperfusion injury studies.		MyD88
T2671	Regadenoson	CVT-3146,Lexiscan	Adenosine Receptor
	Regadenoson (CVT-3146) is an adenosine derivative and selective A2A adenosine receptor agonist with coronary vasodilating activity. Upon administration, regadenoson selectively binds to and activates the A2A adenosine re...		Adenosine Receptor
T23521	VULM 1457		Acyltransferase
	VULM 1457 is a potent ACAT inhibitor. VULM 1457 has remarkable hypolipidaemic activity and improves the overall myocardial ischaemia-reperfusion injury outcomes. VULM1457 significantly reduces production and secretion of...		Acyltransferase
T15418	GS-6201	CVT-6883	Adenosine Receptor
	GS-6201 (CVT-6883) is a selective antagonist of adenosine A2B receptor. GS-6201 shows high affinity and selectivity for the human adenosine A2B receptors with a Ki of 22 nM.		Adenosine Receptor
T1479	Isosorbide dinitrate	Isordil,Nitrosorbide,Sorbide nitrate,Sorbidnitrate	Others , NO Synthase
	Isosorbide dinitrate (Isordil) is a vasodilator used in the treatment of angina pectoris.		Others , NO Synthase
T1239	Indacaterol maleate	QAB149	Adrenergic Receptor
	Indacaterol maleate (QAB149) is an ultra-long-acting β-adrenoceptor agonist.		Adrenergic Receptor
T5329	Trandolapril		Angiotensin-converting Enzyme (ACE)
	Trandolapril is an orally administered angiotensin converting enzyme (ACE) inhibitor that is hydrolysed to the active diacid trandolaprilat.		Angiotensin-converting Enzyme (ACE)
T28178	NLRP3-IN-9	INF-4E,INF 4E,INF4E	NOD
	NLRP3-IN-9 (INF-4E) is an inhibitor of NLRP3 ATPase and caspase-1. NLRP3-IN-9 acts by irreversibly trapping thiol nucleophiles, which prevents both ATP- and nigericin-triggered pyroptosis of human THP-1 cells in a time- ...		NOD
T7714	Temocapil		Tyrosinase
	Temocapril is an inhibitor of tyrosine kinase.		Tyrosinase
T3461	Losartan Carboxylic Acid	EXP-3174,E-3174	RAAS
	Losartan Carboxylic Acid (E-3174) a potent AT1 antagonist (Kis: 0.57 nM, rat; 0.67 nM, human), producing a depressor response and vasodilatation. Losartan Carboxylic Acid , a metabolite of losartan, is more potent than l...		RAAS
T9516	Binodenoson	WRC 0470,MRE-0470,2-(cyclohexylmethylidenehydrazino)adenos	Adenosine Receptor
	Binodenoson (WRC 0470) is a potent and selective A2A adenosine receptor agonist (KD=270 nM). Binodenoson is being developed as a short-acting coronary vasodilator as an adjunct to radiotracers for use in myocardial stres...		Adenosine Receptor
T1046	Mexiletine hydrochloride	KOE-1173 (hydrochloride),Mexiletine HCl,KO1173	AhR , Sodium Channel
	Mexiletine hydrochloride (KOE-1173 hydrochloride) is a voltage-gated sodium channel blocker and a Class IB antiarrhythmic drug. Mexiletine hydrochloride exerts antiarrhythmic effects by inhibiting sodium current in myoca...		AhR , Sodium Channel
T2047	AG-1478	AG1478,NSC 693255,Tyrphostin AG-1478	EGFR , HCV Protease , Influenza Virus , HER , PDGFR
	AG-1478 (NSC-693255) (Tyrphostin AG-1478) is a selective EGFR inhibitor.		EGFR , HCV Protease , Influenza Virus , HER , PDGFR
T1101	Minocycline hydrochloride	Minocycline HCl	HIF/HIF Prolyl-Hydroxylase , Antibacterial , Antibiotic
	Minocycline hydrochloride (Minocycline HCl) is a tetracycline antibiotic with excellent absorption and tissue penetration that is used for several bacterial infections as well as treatment of acne. Minocycline hydrochlor...		HIF/HIF Prolyl-Hydroxylase , Antibacterial , Antibiotic
T3230	NLRP3-IN-2	5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide,NLRP3 Inflammasome Inhibitor I	NOD-like Receptor (NLR) , NOD
	NLRP3-IN-2 (5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide), an intermediate capable of synthesizing glibenclamide, exerts an inhibitory effect on the formation of NLRP3 inflammatory vesicles in cardiomyocytes, limiting i...		NOD-like Receptor (NLR) , NOD
T6698	Temocapril hydrochloride	CS-622 HCl,Acecol,Temocapril HCl,CS-622	RAAS
	Temocapril hydrochloride (CS-622 HCl), the hydrochloride of Temocapril, is a long-acting ACE inhibitor used for the therapy of hypertension.		RAAS
T0143	Bisoprolol hemifumarate	(±)-Bisoprolol hemifumarate,Bisoprolol fumarate,Bisoprolol hemifumarate salt,EMD33512,(±)-Bisoprolol (hemifumarate)	Adrenergic Receptor
	Bisoprolol, a selective beta-1 adrenergic receptor antagonist, selectively and competitively binds to and blocks beta-1 adrenergic receptors in the heart, thereby with antihypertensive activity and devoid of intrinsic sy...		Adrenergic Receptor
T83977	BIIB 722 Mesylate		Sodium Channel
	BIIB 722 Mesylate is a selective sodium-hydrogen exchange inhibitor with cardioprotective properties and can be used to study myocardial ischemia and myocardial infarction.		Sodium Channel
T27827	Libenzapril	CGS 16617,Abutapril	Angiotensin-converting Enzyme (ACE)
	Libenzapril (CGS 16617) is a potent angiotensin-converting enzyme inhibitor used to study myocardial injury.		Angiotensin-converting Enzyme (ACE)
T34648	Sinitrodil	ITF296,ITF-296,ITF 296	Guanylate cyclase
	Sinitrodil (ITF-296) is a guanylate cyclase stimulant that may be used in the treatment of myocardial ischemia and angina pectoris.		Guanylate cyclase
T68130	Pobilukast	SKF 104353 Z2,SKF 104353	Leukotriene Receptor
	Pobilukast (SKF 104353) is a selective cysteinyl leukotriene receptor antagonist that blocks phosphatidylinositol metabolism and leukotriene D-induced thromboxane synthesis, and can be used to study limiting myocardial d...		Leukotriene Receptor
T31640	Enrasentan	SB-217242,SB 217242,SB217242	Endothelin Receptor
	Enrasentan (sb-217242) is a mixed antagonist of ET(A) and ET(B) receptors that reduces blood pressure, prevents cardiac hypertrophy, and protects myocardial function.		Endothelin Receptor
T11039	Didesethyl chloroquine	Bisdesethylchloroquine	Drug Metabolite
	Didesethyl chloroquine (Bisdesethylchloroquine) is an effective myocardial inhibitor. Didesethyl chloroquine (Bisdesethylchloroquine) is the main metabolite of the antimalarial drug chloroquine.		Drug Metabolite
T11239	Ethacizine hydrochloride	NIK-244,Ethacizin,NIK-244 hydrochloride	Sodium Channel
	Ethacizine hydrochloride (NIK-244) has antiarrhythmic activity, and its effects are related to cardiac activity and can be used to study arrhythmias and myocardial infarction.		Sodium Channel
T21821L	REV 5901A	REV 5901 HCl,REV 5901A（101910-24-1 Free base）	Leukotriene Receptor , Lipoxygenase , Antibiotic
	REV 5901A (REV 5901 HCl) is an orally active leukotriene receptor antagonist and 5-lipoxygenase inhibitor with antimicrobial activity that attenuates colon cancer growth in mice.REV 5901A has been used in studies of asth...		Leukotriene Receptor , Lipoxygenase , Antibiotic
T68088	Iodofiltic acid
	Iodofiltic acid can be used in the adjuvant treatment of acute coronary syndromes (Zeus ACS) and can be imaged to detect myocardial ischemia.
T68022L	Sulotroban potassium	BM 13177 potassium,Sulotroban potassium(72131-33-0 Free base)	PPAR
	Sulotroban potassium is a small molecule thromboxane A2 receptor (TXA2R) antagonist that can be used to study myocardial infarction and thrombosis.		PPAR
T28077	MMPP		VEGFR , STAT
	MMPP is a novel VEGFR2 inhibitor with anti-inflammatory and potential anticancer activity, inhibits STAT3, inhibits angiogenesis via VEGFR2/AKT/ERK/NF-kappaB pathway, and can be used to alleviate myocardial injury.		VEGFR , STAT
T67972L	Amp579 TFA	Amp579 TFA(213453-89-5 Free base)	Adenosine Receptor
	Amp579 TFA is a novel adenosine A1/A2a receptor agonist that induces acute and delayed preconditioning against myocardial shock in vivo.		Adenosine Receptor
T23356	Linsidomine hydrochloride	SIN-1 chloride	Others
	Linsidomine hydrochloride (SIN-1 chloride) is considered as a metabolite of moxidomine, with vasodilation, inhibition of platelet aggregation, and antiangina activity. In myocardial ischemia-reperfusion models, Linsidomi...		Others
T67941	PDE5-IN-9
	PDE5-IN-9 inhibits Phosphodiesterase PDE1c and is used to treat hypertension, heart failure, myocardial infarction, kidney failure, asthma, bronchitis, and dementia.
T61933	MK-0159		CD38
	MK-0159 is an orally available, highly potent CD38 inhibitor with myocardial injury protection for the study of cardiac ischemia and reperfusion injury.		CD38
T8687	Diaminohydroxypropanetetraacetic acid		Others
	Diaminohydroxypropanetetraacetic acid has been investigated for the treatment of Vascular Disease, Coronary Disease, Myocardial Ischemia, Coronary Restenosis, and Coronary Artery Disease, among others		Others
T1146	Nifedipine	BAY-a-1040,Procardia XL,Procardia,Adalat	CaMK , Potassium Channel , Calcium Channel , Autophagy
	Nifedipine (Procardia) is a dihydropyridine calcium channel blocking agent. Nifedipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation ...		CaMK , Potassium Channel , Calcium Channel , Autophagy
T24115	GSK854	GSK-854,GSK 854	Apoptosis
	GSK854 is a highly selective and potent inhibitor of troponin I interacting kinase (TNNI3K) that inhibits myocardial infarction-injured cellular pyroptosis and apoptosis in mice, which may limit oxidative stress, injury,...		Apoptosis
T12078	ML334	LH601A	Nrf2
			Nrf2
T3597	Cutamesine dihydrochloride	AGY94806 dihydrochloride,SA4503 (dihydrochloride),SA4503 dihydrochloride	Sigma receptor
	Cutamesine dihydrochloride (SA4503 dihydrochloride) is a selective σ1 receptor agonist (IC50: 17.4 nM). It shows selectivity for σ1 over σ2 receptors, and inhibits angiotensin II-induced cardiomyocyte hypertrophy in vitr...		Sigma receptor
T6633	Ranolazine	CVT 303,Ranexa,RS 43285-003	Calcium Channel , Sodium Channel
	Ranolazine (RS 43285-003) is a calcium uptake inhibitor via the sodium/calcium channel, used to treat chronic angina. It affects the sodium-dependent calcium channels during myocardial ischemia in rabbits by altering the...		Calcium Channel , Sodium Channel
T20563	PD-166793	PD-166793-0000,PD 166793,PD166793	MMP
	PD-166793 is an orally active, potent and selective MMP inhibitor with inhibitory effects on MMP-2, MMP-3 and MMP-13.PD-166793 ameliorates myocardial ischemia and reperfusion injury in a rat model of heart failure.PD-166...		MMP
T0988	Trimetazidine dihydrochloride	Yoshimilon,Kyurinett,Vastarel F	Autophagy , Fatty Acid Synthase
	Trimetazidine dihydrochloride (Vastarel F) can improve myocardial glucose utilization by inhibiting fatty acid metabolism. Trimetazidine is the first cytoprotective anti-ischemic agent, also used as a vasodilator in isch...		Autophagy , Fatty Acid Synthase
TP2279L	Obestatin (rat) acetate		GHSR
	Obestatin (rat) acetate is an endogenous ligand of G-protein coupled receptor 39 (GPR39). Obestatin (rat) acetate has anti-inflammatory, anti-myocardial infarction and antioxidant properties. Obestatin (rat) acetate supp...		GHSR
T9180	LUF6096	CF-602	Adenosine Receptor
	LUF6096 (CF-602) is a potent allosteric enhancer of the adenosine A3 receptor, exhibiting the capability to enhance agonist binding allosterically while demonstrating low orthosteric affinity across adenosine receptors. ...		Adenosine Receptor
T0230	Prasugrel	LY640315,CS-747,PCR 4099	P2Y Receptor
	Prasugrel (CS-747) is a piperazine derivative and PLATELET AGGREGATION INHIBITOR that is used to prevent THROMBOSIS in patients with ACUTE CORONARY SYNDROME; UNSTABLE ANGINA and MYOCARDIAL INFARCTION, as well as in those...		P2Y Receptor
T39115	ABR-238901		TLR
	ABR-238901 is an oral, active S100A8/A9 blocker that inhibits the interaction of S100A8/A9 with its receptors RAGE(receptor for advanced glycation end products) and TLR4 (toll-like receptor 4). ABR-238901 has potential a...		TLR

Compounds

Resorcinolnaphthalein

Target: Adrenergic Receptor

Gap19

TP1563

Synonym:

Target: Gap Junction Protein

DG-041

T15108

Synonym:

Target: Prostaglandin Receptor

Amrinone

T1265

Synonym: Inamrinone,Inocor,Wincoram

Target: 5-HT Receptor

Synonym: CVT-3146,Lexiscan

Target: Adenosine Receptor

VULM 1457

T23521

Synonym:

Target: Acyltransferase

GS-6201

T15418

Synonym: CVT-6883

Target: Adenosine Receptor

Isosorbide dinitrate

T1479

Synonym: Isordil,Nitrosorbide,Sorbide nitrate,Sorbidnitrate

Target: Others, NO Synthase

Indacaterol maleate

T1239

Synonym: QAB149

Target: Adrenergic Receptor

Trandolapril

T5329

Synonym:

Target: Angiotensin-converting Enzyme (ACE)

NLRP3-IN-9

T28178

Synonym: INF-4E,INF 4E,INF4E

Losartan Carboxylic Acid

T3461

Synonym: EXP-3174,E-3174

Target: RAAS

Binodenoson

T9516

Synonym: WRC 0470,MRE-0470,2-(cyclohexylmethylidenehydrazino)adenos

Target: Adenosine Receptor

Mexiletine hydrochloride

T1046

Synonym: KOE-1173 (hydrochloride),Mexiletine HCl,KO1173

Target: AhR, Sodium Channel

AG-1478

T2047

Synonym: AG1478,NSC 693255,Tyrphostin AG-1478

Target: EGFR, HCV Protease, Influenza Virus, HER, PDGFR

Minocycline hydrochloride

T1101

Synonym: Minocycline HCl

Target: HIF/HIF Prolyl-Hydroxylase, Antibacterial, Antibiotic

NLRP3-IN-2

T3230

Synonym: 5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide,NLRP3 Inflammasome Inhibitor I

Target: NOD-like Receptor (NLR), NOD

Temocapril hydrochloride

T6698

Synonym: CS-622 HCl,Acecol,Temocapril HCl,CS-622

Target: RAAS

Bisoprolol hemifumarate

T0143

Synonym: (±)-Bisoprolol hemifumarate,Bisoprolol fumarate,Bisoprolol hemifumarate salt,EMD33512,(±)-Bisoprolol (hemifumarate)

Target: Adrenergic Receptor

BIIB 722 Mesylate

T83977

Synonym:

Target: Sodium Channel

Libenzapril

T27827

Synonym: CGS 16617,Abutapril

Target: Angiotensin-converting Enzyme (ACE)

Sinitrodil

T34648

Synonym: ITF296,ITF-296,ITF 296

Target: Guanylate cyclase

Pobilukast

T68130

Synonym: SKF 104353 Z2,SKF 104353

Target: Leukotriene Receptor

Enrasentan

T31640

Synonym: SB-217242,SB 217242,SB217242

Target: Endothelin Receptor

Didesethyl chloroquine

T11039

Synonym: Bisdesethylchloroquine

Target: Drug Metabolite

Ethacizine hydrochloride

T11239

Synonym: NIK-244,Ethacizin,NIK-244 hydrochloride

Target: Sodium Channel

REV 5901A

T21821L

Synonym: REV 5901 HCl,REV 5901A（101910-24-1 Free base）

Target: Leukotriene Receptor, Lipoxygenase, Antibiotic

Synonym: BM 13177 potassium,Sulotroban potassium(72131-33-0 Free base)

Synonym: Amp579 TFA(213453-89-5 Free base)

Target: Adenosine Receptor

Linsidomine hydrochloride

T23356

Synonym: SIN-1 chloride

diaminohydroxypropanetetraacetic acid

Synonym: BAY-a-1040,Procardia XL,Procardia,Adalat

Target: CaMK, Potassium Channel, Calcium Channel, Autophagy

GSK854

T24115

Synonym: GSK-854,GSK 854

Cutamesine dihydrochloride

T3597

Synonym: AGY94806 dihydrochloride,SA4503 (dihydrochloride),SA4503 dihydrochloride

Target: Sigma receptor

Ranolazine

T6633

Synonym: CVT 303,Ranexa,RS 43285-003

Target: Calcium Channel, Sodium Channel

PD-166793

T20563

Synonym: PD-166793-0000,PD 166793,PD166793

Target: MMP

Trimetazidine dihydrochloride

T0988

Synonym: Yoshimilon,Kyurinett,Vastarel F

Target: Autophagy, Fatty Acid Synthase

Obestatin (rat) acetate

Target: Adenosine Receptor

Prasugrel

T0230

Synonym: LY640315,CS-747,PCR 4099

カタログ番号	製品名	別名	ターゲット
T8158	Tilianin		Others
	Tilianin is a flavonoid glycoside of Dragocephalum moldavicum L.		Others
TN6490	Regaloside C		Others
	Regaloside C is a glycerol glucoside isolated from Lilium genus with anti-inflammatory properties.		Others
T2893	Muscone	3-Methylcyclopentadecanone,Methylexaltone	MMP , TNF , NF-κB , NOD-like Receptor (NLR) , P-gp , Interleukin
	Muscone (3-Methylcyclopentadecanone) is an organic compound that is the primary contributor to the odor of musk.
T5247	Trimethylamine N-oxide dihydrate	TMANO Dihydrate	Others , Endogenous Metabolite
	Trimethylamine N-oxide dihydrate (TMANO Dihydrate), a product of the oxidation of trimethylamine, is considered as a protein stabilizer that may serve to counteract urea, the major osmolyte of sharks, skates and rays.		Others , Endogenous Metabolite
T3S0289	Araloside X		Calcium Channel
	Aralosides possess protective effect against experimental myocardial ischemia and infarction, the mechanism of myocardial protection may be attributed to the amelioration of FFA metabolic deterioration and membrane perox...		Calcium Channel
T2844	Hyperoside	Quercetin 3-galactoside,Hyperin	Others , Influenza Virus , Antifungal
	Hyperoside (Hyperin) is a naturally occuring flavonoid compound which shows multiple bioactivities, including myocardial protection, anti-redox, and anti-inflammatory activities.		Others , Influenza Virus , Antifungal
TN7089	Alashinol G	(-)-Carinol	Others
	Alashinol G ((-)-Carinol) is isolated from the stem bark of Syringa pinnatifolia, a Mongolian folk medicine with anti-myocardial ischaemic effects.		Others
T5S2178	Fargesin	(+/-)-Fargesin	Adrenergic Receptor
	1. Fargesin ((+/-)-Fargesin) as a potential β1AR antagonist through cAMP/PKA pathway could protect against myocardial ischemia/reperfusion injury in rats. 2. Fargesin improves dyslipidemia and hyperglycemia by activating...		Adrenergic Receptor
T5S1632	Barlerin	8-O-Acetylshanzhiside methyl ester,ND01	VEGFR , TNF , NF-κB , Akt , Caspase
	Barlerin (8-O-Acetylshanzhiside methyl ester) has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced injury might be due to the suppression of intracellular Ca2+ e...		VEGFR , TNF , NF-κB , Akt , Caspase
T5S0053	Coptisine	Coptisin	Indoleamine 2,3-Dioxygenase (IDO)
	1. Coptisine (Coptisin) treatment increases cell viability based on its reversal effect on the enhanced activity of Indoleamine 2, 3-dioxygenase . 2. Coptisine treats myocardial I/R likely through suppressing myocardial ...		Indoleamine 2,3-Dioxygenase (IDO)
T2S0500	Ilexsaponin A	Ilexsaponin A1	Others
	1. Ilexsaponin A (Ilexsaponin A1) shows protective effects on ischemia-reperfusion-induced myocardial injury through anti-apoptotic pathway.		Others
T3920	Pseudoginsenoside F11	Ginsenoside A1	Others , Endogenous Metabolite
	Pseudoginsenoside F11 (Ginsenoside A1) is a component of Panax quinquefolium (American ginseng) which main pharmacological activities are positive inotropic effect on isolated heart function, good therapeutic effect on m...		Others , Endogenous Metabolite
T4518	Licochalcone D		ERK , NF-κB
	Licochalcone D may be a potential drug for human melanoma treatment by inhibiting proliferation, inducing apoptosis via the mitochondrial pathway and blocking cell migration and invasion. Licochalcone D has cardioprotect...		ERK , NF-κB
T3427	Polydatin	Piceid,Polydotin Peceid	Apoptosis , Mitophagy , NF-κB , Autophagy
	Polydatin (Piceid), the glycoside of Resveratrol, is originally isolated from the Chinese herb Polygonum cuspidatum. The compound can inhibit platelet aggregation and elevate the ratios of LDL-C/HDL-C and TC/HDL-C. In th...		Apoptosis , Mitophagy , NF-κB , Autophagy
T3921	Punicalagin		SARS-CoV , HBV
	Punicalagin is a major ellagitannin found in pomegranates that is reported to produce antioxidant, anti-inflammatory, and anticancer effects. It has been shown to prevent high-fat diet-induced obesity-associated accumula...		SARS-CoV , HBV
T3S1553	Trans-Cinnamaldehyde	Cinnamaldehyde,Cinnamic aldehyde,Cinnamal,Phenylacrolein	COX , Endogenous Metabolite
	1. trans-Cinnamaldehyde (Phenylacrolein) exhibits excellent anti-inflammatory activities and antidepressant-like effects in stressed mid-aged rats as a COX-2 inhibitor. 2. Cinnamic aldehyde induces apoptosis of CML cells...		COX , Endogenous Metabolite
T3753	Sinapinic Acid	Sinapic acid,Synapoic acid	Apoptosis , RAAS , Reactive Oxygen Species , HDAC
	Sinapinic Acid (Synapoic acid) protects the rat liver from CCl4-induced inflammation, most likely by acting as a free radical scavenger and modulator of NF-κB p65 activation and proinflammatory cytokine expression. Sinap...		Apoptosis , RAAS , Reactive Oxygen Species , HDAC
T2973	Astragaloside IV	AST-IV,AS-IV	MMP , ERK , Estrogen/progestogen Receptor , JNK
	Astragaloside IV (AS-IV), an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cel...		MMP , ERK , Estrogen/progestogen Receptor , JNK
T4S2326	Cornuside	7-Galloylsecologanol,7-O-Galloylsecologanol,Comuside	ERK , p38 MAPK , NF-κB , JNK
	1. Cornuside (Comuside) has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human endothelial cells. 3. Cornuside can treat myocardi...		ERK , p38 MAPK , NF-κB , JNK
TN4882	Quinine HCl		Adrenergic Receptor
	Quinine HCl produces alpha-adrenergic blockade. Quinine modifies catecholamine- and calcium-induced myocardial contractile force responses.		Adrenergic Receptor
T4S0280	Eleutheroside D
	Eleutheroside has protective effect to myocardial ischemic-reperfusion injury(IRI) in isolated rats.
TN1101	20(R)-Notoginsenoside R2		Others
	20(R)-Notoginsenoside R2 is a natural product with Promote blood circulation and improve myocardial ischemia		Others
TN1431	Baohuoside VII		Others
	Baohuoside aglycone possesses cardioprotective effect in prevention of ischemia/ reperfusion injury and reduce the myocardial infraction, the mechnism is due to the reduction of the injury of free radicals. Baohuoside VI...		Others
T78489	Lotusine hydroxide
	Lotusine (hydroxide), a pure alkaloid isolated from the green seed embryos of Nelumbo nucifera Gaertn, influences action potentials in myocardial tissue and the slow inward current in cardiac Purkinje fibers [1].
TN3914	Echinatine		ATPase , IL Receptor , TNF
	Echinatin exerts a protective effect against ischemia/reperfusion (I/R)-induced myocardial injury on hearts, this effect may be attributed to the antioxidant and anti-inflammatory activities of this compound. Echinatin c...		ATPase , IL Receptor , TNF
TN1875	Liriodenine		BCL , Caspase , p53
	Liriodenine is a potent inhibitor of topoisomerase II (EC 5.99.1.3) both in vivo and in vitro, it has antitumor, antibacterial and antifungal activities, it can suppress ventricular arrhythmias induced by myocardial isch...		BCL , Caspase , p53

天然物製品

Synonym: 3-Methylcyclopentadecanone,Methylexaltone

Target: MMP, TNF, NF-κB, NOD-like Receptor (NLR), P-gp, Interleukin

Trimethylamine N-oxide dihydrate

T5247

Synonym: TMANO Dihydrate

Target: Others, Endogenous Metabolite

Araloside X

T3S0289

Synonym:

Target: Calcium Channel

Hyperoside

T2844

Synonym: Quercetin 3-galactoside,Hyperin

Target: Others, Influenza Virus, Antifungal

Synonym: (+/-)-Fargesin

Target: Adrenergic Receptor

Barlerin

T5S1632

Synonym: 8-O-Acetylshanzhiside methyl ester,ND01

Target: VEGFR, TNF, NF-κB, Akt, Caspase

Coptisine

T5S0053

Synonym: Coptisin

Target: Indoleamine 2,3-Dioxygenase (IDO)

Ilexsaponin A

T2S0500

Synonym: Ilexsaponin A1

Target: Others

Pseudoginsenoside F11

T3920

Synonym: Ginsenoside A1

Target: Others, Endogenous Metabolite

Synonym: Piceid,Polydotin Peceid

Target: Apoptosis, Mitophagy, NF-κB, Autophagy

Punicalagin

T3921

Synonym:

Target: SARS-CoV, HBV

trans-Cinnamaldehyde

T3S1553

Synonym: Cinnamaldehyde,Cinnamic aldehyde,Cinnamal,Phenylacrolein

Target: COX, Endogenous Metabolite

Sinapinic Acid

T3753

Synonym: Sinapic acid,Synapoic acid

Target: Apoptosis, RAAS, Reactive Oxygen Species, HDAC

Astragaloside IV

T2973

Synonym: AST-IV,AS-IV

Target: MMP, ERK, Estrogen/progestogen Receptor, JNK

Cornuside

T4S2326

Synonym: 7-Galloylsecologanol,7-O-Galloylsecologanol,Comuside

Target: ERK, p38 MAPK, NF-κB, JNK

Quinine HCl

TN4882

Synonym:

Target: Adrenergic Receptor

20(R)-Notoginsenoside R2

Target: ATPase, IL Receptor, TNF

Liriodenine

TN1875

Synonym:

Target: BCL, Caspase, p53

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-05004	FGF-4 Protein, Human, Recombinant	Human	E. coli
	FGF (fibroblast growth factor) signalling is known to be required for many aspects of mesoderm formation and patterning during Xenopus development and has been implicated in regulating genes required for the specificati...
TMPY-00545	Dermcidin Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Hepatocellular carcinoma (HCC) is a major contributor to cancer-related deaths due to its often late stage diagnosis, and dermcidin (DCD) may have the potential to be used as a serum biomarker for HCC for more timely dia...
TMPY-00369	LY6D Protein, Human, Recombinant (mFc)	Human	HEK293 Cells
	LY6D (Lymphocyte Antigen 6 Family Member D) is a Protein Coding gene. It may act as a specification marker at the earliest stage specification of lymphocytes between B- and T-cell development. Marks the earliest stage of...
TMPK-01229	IL-19 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Interleukin-19 (IL-19) has been shown to be involved in coronary artery diseases and atherosclerosis, while its expression in myocardial infarction is poorly understood. In this study, the dynamic increase in circulating...
TMPH-01595	KMO Protein, Human, Recombinant (His)	Human	E. coli
	Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA r...
TMPY-01481	FLAP Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP), also known as FLAP, belongs to the MAPEG family. ALOX5AP/FLAP is an essential partner of 5-LO for this process. The FLAP (ALOX5AP) gene has been linked to risk fo...
TMPJ-00402	CD117 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	C-Kit/SCF R is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to ...
TMPJ-00091	G-CSF Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Granulocyte colony-stimulating factor (G-CSF) is a growth factor and an essential cytokine which belongs to the IL-6 superfamily. Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis ...
TMPJ-00785	FABP3 Protein, Human, Recombinant (His)	Human	E. coli
	Fatty Acid Binding Protein 3 (FABP3) is a small cytoplasmic protein (15 kDa) that is released from cardiac myocytes following an ischemic episode. Like the nine other distinct FABPs that have been identified, FABP3 is in...
TMPJ-00362	MMP-2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	72 kDa type IV collagenase also known as matrix metalloproteinase-2 (MMP-2) and gelatinase A is an enzyme that in humans is encoded by the MMP2 gene.It belongs to the matrix metalloproteinase (MMP) family. Matrix metallo...
TMPY-04387	AKT2 Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	AKT (AK mouse plus Transforming or Thymoma) is a frequent oncogene expressed in most tissues which includes three isoforms AKT1, AKT2, and AKT3. Hyperactivation of AKT signaling is a central key in many human cancer prog...
TMPJ-00952	CXCL12 Protein, Mouse, Recombinant	Mouse	E. coli
	Mouse Cxcl12 is a secreted and highly conserved protein which belongs to the intercrine alpha (chemokine CxC) family.CXCL12 is widely expressed in various organs including brain, kidney, skeletal muscle, heart, liver, an...
TMPY-00681	BMP-5 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Bone Morphogenetic Protein 5 (BMP-5) is a member of the structurally and functionally related bone morphogenetic proteins (BMPs) which constitute a novel subfamily of the transforming growth factor β (TGF-β) superfamily....

FGF-4 Protein, Human, Recombinant

TMPY-05004

Species: Human

Expression System: E. coli

Dermcidin Protein, Human, Recombinant (hFc)

TMPY-00545

Species: Human

Expression System: HEK293 Cells

LY6D Protein, Human, Recombinant (mFc)

TMPY-00369

Species: Human

Expression System: HEK293 Cells

IL-19 Protein, Human, Recombinant (hFc)

TMPK-01229

Species: Human

Expression System: HEK293 Cells

KMO Protein, Human, Recombinant (His)

TMPH-01595

Species: Human

Expression System: E. coli

FLAP Protein, Human, Recombinant (His)

TMPY-01481

Species: Human

Expression System: Baculovirus Insect Cells

CD117 Protein, Human, Recombinant (hFc)

TMPJ-00402

Species: Human

Expression System: HEK293 Cells

G-CSF Protein, Mouse, Recombinant (His)

TMPJ-00091

Species: Mouse

Expression System: HEK293 Cells

FABP3 Protein, Human, Recombinant (His)

TMPJ-00785

Species: Human

Expression System: E. coli

MMP-2 Protein, Human, Recombinant (His)

TMPJ-00362

Species: Human

Expression System: HEK293 Cells

AKT2 Protein, Human, Recombinant (His & GST)

TMPY-04387

Species: Human

Expression System: Baculovirus Insect Cells

CXCL12 Protein, Mouse, Recombinant

TMPJ-00952

Species: Mouse

Expression System: E. coli

BMP-5 Protein, Human, Recombinant (hFc)

TMPY-00681

Species: Human

Expression System: HEK293 Cells

カタログ番号	製品名
L2910	Antioxidant Compound Library	1314 compounds
	Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species (ROS) and a biological system's ability to readily detoxify the reactive intermediates or repair the resulting damage. ...
L6750	PBCRBS Traditional Chinese Medicine Compound Library	580 compounds
	A unique collection of 580 compounds derived from traditional Chinese medicines (TCMs) for promoting blood circulation and removing blood stasis.

ライブラリー

Antioxidant Compound Library

L2910

Compounds: 1314

PBCRBS Traditional Chinese Medicine Compound Library

L6750

Compounds: 580