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カタログ番号 | 製品名 | 別名 | ターゲット |
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T29668 | ADP-2341 | ADP 2341 | |
ADP-2341 is a soluble analog of FiVe1. | |||
T29669 | ADP-Ribosylarginine | alpha-ADP-ribosylarginine | |
ADP-Ribosylarginine can regulate cell proliferation and tumorigenesis. | |||
T37118 | ADP-Glucose (sodium salt) | ADPG,Adenosine-5'-diphosphoglucose,ADP-Glucose (sodium salt) | |
ADP-Glucose (ADPG) is an immediate precursor used in the biosynthesis, by glucose addition, of storage polysaccharides in plants, green algae, and cyanobacteria, as well as structural polysaccharides in certain bacteria.... | |||
T37475 | Cyclic ADP-Ribose (ammonium salt) | cADP-Ribose,cADPR,Cyclic ADP-Ribose (ammonium salt) | |
Cyclic ADP-ribose (cADP-ribose) is an endogenous metabolite of NAD+ that mobilizes the release of stored Ca2+ in the endoplasmic reticulum via ryanodine receptors in various cell types.[1],[2],[3],[4],[5] This second mes... | |||
T29348 | 2-Fluoro-ADP | ||
2-Fluoro-ADP is a bioactive chemical. | |||
T10247 | Adenosine 5'-diphosphoribose sodium | Adenosine 5'-diphosphoribose sodium,ADP ribose sodium | Endogenous Metabolite , TRP/TRPV Channel , Autophagy |
T37803 | 8-bromo-Cyclic ADP-Ribose (sodium salt) | ||
Cyclic ADP-ribose (cADP-ribose) is a calcium mobilizing nucleotide that is biosynthesized from NAD+ by cADP-ribose synthases, including CD38. cADP-Ribose appears to activate calcium channels in intracellular membranes, w... | |||
T63538 | 8-Azido-ADP disodium | ||
8-Azido-ADP (disodium) is a covalently bound inhibitor of mitochondrial adenine nucleotide translocation that exhibits inhibition of the ADP-induced 4 to 3 normal shift in mitochondrial respiration. In a light-dependent ... | |||
T23581 | 2-Methylthioadenosine diphosphate trisodium | 2 Methylthio ADP,2MeSADP,2-Methylthio-ADP,2 MeS ADP,2-MeS-ADP | |
2-MeS-ADP is a purinergic agonist that acts by displaying selectivity for P2Y1, P2Y12, and P2Y13 receptors and inhibiting cAMP accumulation. | |||
T50098 | TIQ-A | PARP | |
TIQ-A is a PARP1 inhibitor which involved in DNA single-strand break repair via the base excision repair pathway. PARP1 is triggered by DNA damage and its excessive activation has been proposed as a causative factor in m... | |||
T78401 | PNP-ADPr disodium | ADP-ribose-pNP disodium | |
pNP-ADPr disodium serves as a colorimetric substrate in the inaugural continuous assays of Poly(ADP-ribose) glycohydrolase (PARG) and ADP-ribosyl hydrolase 3 (ARH3) activities. It also facilitates research into poly(ADP-... | |||
T41083 | PNP-ADPr | pNP-ADPr,ADP-ribose-pNP | |
pNP-ADPr is a colorimetric substrate employed in the first continuous activity assays for Poly(ADP-ribose) glycohydrolase (PARG) and ADP-ribosyl hydrolase 3 (ARH3). Its utilization facilitates research on poly(ADP-ribose... | |||
T32764 | Linear-benzoadenosine diphosphate | Lin-benzo-ADP | |
Linear-benzoadenosine diphosphate is a nucleotide analog. | |||
T83805 | Rp-Adenosine-5'-O-(1-thiodiphosphate) sodium | Rp-ADP-α-S | |
Rp-Adenosine-5'-O-(1-thiodiphosphate) (Rp-ADP-α-S), a sulfur-containing isomer of the nucleotide derivative ADP-α-S, acts as an inhibitor of phosphorylase kinase with an inhibition constant (Ki) of 0.53 µM. This compound... | |||
T83785 | 2-Chloroadenosine-5'-O-diphosphate sodium | 2-chloro ADP | |
2-Chloroadenosine-5'-O-diphosphate, a purine nucleotide adenosine 5'diphosphate (ADP) derivative, demonstrates multiple biological activities. It promotes aggregation and inhibits cyclic AMP (cAMP) production, triggered ... | |||
T83806 | Sp-Adenosine-5'-O-(1-thiodiphosphate) sodium | Sp-ADP-α-S | |
Sp-Adenosine-5’-O-(1-thiodiphosphate) (Sp-ADP-α-S), an isomer of the sulfur-containing nucleotide derivative ADP-α-S, functions as an inhibitor of phosphorylase kinase with an inhibition constant (Ki) of 0.53 µM. This co... | |||
T22749 | DR2313 | DR 2313 | PARP |
DR2313 is a competitive inhibitor of poly(ADP-ribose) polymerase (IC50: 0.20 and 0.24 μM for PARP-1 and PARP-2 respectively). It also has neuroprotective. | |||
T16761 | RK-287107 | Others , PARP | |
RK-287107 is an effective and specific inhibitor of tankyrase (IC50s: 14.3 and 10.6 nM for tankyrase-1 and tankyrase-2, respectively). | |||
T8964 | G244-LM | Others , PARP | |
G244-LM is a potent and specific inhibitor of tankyrase 1/2. G244-LM inhibits Wnt signaling. | |||
T83813 | 8-Azidoadenosine-5'-O-diphosphate sodium | 8-azido-ADP,Click Tag™ 8-Azidoadenosine-5'-O-diphosphate | |
8-Azidoadenosine-5'-O-diphosphate (8-azido-ADP), a clickable variant of the ATP precursor and purinergic receptor ligand ADP, serves as a photoaffinity label for proteins including glutamate dehydrogenase (GDH) isoprotei... | |||
T15639 | K-756 | PARP , Wnt/beta-catenin | |
T1807 | JW 55 | JW55 | PARP , Wnt/beta-catenin |
JW 55 (JW55) is an effective and selective β-catenin signaling pathway inhibitor, works by inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2). | |||
T3168 | MN-64 | MN64 | Others , PARP , Wnt/beta-catenin |
MN-64 is a tankyrases inhibitor, showed 6 nM potency against tankyrase 1, isoenzyme selectivity, and Wnt signaling inhibition. | |||
T6842 | G007-LK | PARP , Wnt/beta-catenin | |
G007-LK is a selective inhibitor of TNKS1 and TNKS2, with IC50s of 46 nM and 25 nM, respectively. | |||
T6181 | UPF 1069 | PARP | |
UPF 1069 is a specific PARP2 inhibitor ( IC50: 0.3 μM). It is ~27-fold selective against PARP1. | |||
T6578 | ME0328 | PARP | |
ME0328 is a potent and selective PARP inhibitor with IC50 of 0.89 μM for PARP3, about 7-fold selectivity over PARP1. | |||
T2484 | AZD-2461 | PARP | |
AZD2461 is a novel PARP inhibitor. | |||
T6768 | AZ6102 | PARP , Wnt/beta-catenin | |
AZ6102 is a potent TNKS1/2 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows IC50 of 5 nM for Wnt pathway inhibition in DLD-1 cells. | |||
T6197 | PJ34 | PARP | |
PJ34 HCl is the hydrochloride salt of PJ34, which is a PARP inhibitor with EC50 of 20 nM and is equally potent to PARP1/2. | |||
T21524 | 4-amino-1,8-Naphthalimide | PARP | |
4-amino-1,8-Naphthalimide (4-ANI) is a PARP inhibitor with IC50 of 180 nM | |||
T7042 | 1,5-Isoquinolinediol | PARP | |
1, 5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC50: 0.39 μM). The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis. 1, 5-Isoquinolinediol... | |||
T22264 | AZ9482 | PARP | |
AZ9482 is a selective and potent inhibitor of PARP featuring an amide linkage to a 2-piperazinyl-3-cyano-pyridine. AZ9482 exhibits very potent activity of centrosome declustering with EC50 of < 18 nM in HeLa cells. | |||
T39785L | TH5427 | NUDIX hydrolase | |
TH5427 is a lead NUDT5 inhibitor(MG assay IC50 = 29 nM). | |||
T3062 | WIKI4 | PARP , Wnt/beta-catenin | |
WIKI4 is a potent inhibitor of Wnt/β-catenin signaling and tankyrase 2 (TNKS2). | |||
T6339 | AG14361 | AG 14361,AG-14361 | PARP |
AG14361 is an effective inhibitor of PARP1 (Ki<5 nM). | |||
T5058 | Pamiparib | BGB-290 | PARP |
Pamiparib (BGB-290) is an orally active, potent, highly selective PARP inhibitor(IC50 of 0.9 nM and 0.5 nM for PARP1 and PARP2, respectively). It has potent PARP trapping, and capability to penetrate the brain, and can b... | |||
T4022 | QS11 | QS 11 | GTPase |
QS11 is a GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor. Modulates ARF-GTP levels and synergizes with the Wnt/β-catenin signaling pathway to upregulate β-catenin nuclear translocation. Also r... | |||
T4471 | E7449 | Stenoparib,UNII-9X5A2QIA7C | Others , PARP |
E7449 (UNII-9X5A2QIA7C) is a potent PARP1 and PARP2 inhibitor and also inhibits TNKS1 and TNKS2, with IC50s of 2.0, 1.0, ~50 and ~50 nM for PARP1, PARP2, TNKS1 and TNKS2, respectively, using 32P-NAD+ as substrate. | |||
T9165 | AZD5305 | PARP | |
AZD5305 is a potent, selective and oral active PARP inhibitor. | |||
T4472 | NMS-P118 | PARP | |
NMS-P118 is a potent, selective and orally available Inhibitor of PARP-1 for cancer therapy. | |||
T22414 | RBN012759 | PARP | |
RBN012759, a potent and selective PARP14 inhibitor, decreases pro-tumor macrophage function and elicits inflammatory responses in tumor explants. | |||
T9593 | Senaparib | IMP4297 | PARP |
Senaparib (IMP4297) is a novel highly potent and selective oral PARP1/2 inhibitor with strong antitumor activity. | |||
T3649 | BGP-15 | BGP15,BGP-15 2HCl | PARP |
BGP-15 (BGP-15 2HCl) is a PARP inhibitor with protecting effect after ischemia-reperfusion injury. | |||
T12695 | RBN-2397 | PARP | |
RBN-2397 is a potent, selective and orally active accross species NAD+ competitive PARP7 inhibitor with IC50 less than 3 nM. | |||
T9497 | Niraparib tosylate monohyrate | PARP | |
Niraparib, also know as MK-4827, is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. MK4827 inhibits PARP activity, enhancing the accumulation of DNA strand breaks and promoting... | |||
T7896 | BYK204165 | RT-017290 | PARP |
BYK204165 (RT-017290) is a potent PARP inhibitor (PARP1; IC50 = 44.67 nM for human recombinant PARP1 in an enzyme assay) | |||
T5399 | GeA-69 | PARP | |
GeA-69 (GeA69) is a selective and allosteric PARP14 macrodomain 2 (MD2) inhibitor (Kd: 0.86 μM in ITC assays). | |||
T2124 | PJ34 hydrochloride | PJ34 HCl | PARP |
PJ34 hydrochloride (PJ34 HCl) is a potent specific inhibitor of PARPl/2. | |||
T9430 | Venadaparib | NOV140101,IDX-1197 | PARP |
Venadaparib (NOV140101) (IDX-1197) is a potent, selective and orally active PARP inhibitor with IC50s of 1.4 nM and 1.0 nM for PARP1 and PARP2, respectively. Venadaparib is insensitive to PARP-5. Venadaparib prevents the... | |||
T15588 | Iobenguane sulfate | MIBG sulfate | Others |
Iobenguane sulfate (MIBG sulfate) is a high-affinity substrate for cholera toxin that interferes with cellular mono(ADP-ribosylation). Radioiodinated Iobenguane sulfate is clinically used as a tumor-targeted radiopharmac... |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T37687 | Cyclic ADP-ribose ammonium | ||
Cyclic ADP-ribose ammonium (cADPR ammonium) is a powerful calcium mobilization second messenger synthesized from NAD+ by an ADP-ribosyl cyclase. It primarily raises cytosolic calcium levels through Ryanodine receptor-med... | |||
T19253 | Cyclic ADP-ribose | cADPR | Calcium Channel |
Cyclic ADP-ribose (cADPR) is an effective calcium mobilization second messenger, which is synthesized from NAD + by ADP-ribosyl cyclase. Cyclic ADP-ribose mainly increases cytosolic calcium through Ryanodine receptor-med... | |||
T1723 | Adenosine 5'-diphosphate | Adenosine diphosphate,adenosine pyrophosphate,ADP | Endogenous Metabolite |
Adenosine 5'-diphosphate (ADP) induces human platelet aggregation and non-competitively blocks the stimulated human platelet adenylate cyclase. | |||
T5079 | Adenosine 5'-diphosphate sodium salt | Adenosine-5'-diphosphate trisodium salt,ADP sodium salt | Others , Endogenous Metabolite |
Adenosine 5'-diphosphate sodium salt (ADP sodium salt) is an adenine nucleotide that is phosphorylated into ATP by ATPase. This phosphorylation is a key part of cellular homeostatis as it allows for energy storage and is... | |||
T83789 | 7-Deazaadenosine-5'-O-diphosphate sodium | 7-CH-ADP,Tubercidin 5’-diphosphate,TuDP | |
7-Deazaadenosine-5'-O-diphosphate, a modified nucleotide and metabolite of tubercidin, is generated through phosphorylation of tubercidin and further undergoes phosphorylation to become the active metabolite 7-deazaadeno... | |||
T8184 | Fucosterol | PARP , Endogenous Metabolite , PPAR | |
Fucosterol is isolated from E. stolonifera with anti-diabetic, anti-adipogenic and anti-cancer activities. It regulates adipogenesis via modulation of PPARα and C/EBPα expression. | |||
T7443 | 4'-Methoxychalcone | PARP , PPAR | |
4'-Methoxychalcone with a variety of pharmacological activities, such as anti-tumor and anti-inflammatory activities. | |||
T8150 | Nudifloramide | 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide | PARP , Endogenous Metabolite |
Nudifloramide (1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide) is one of the end degradation products of nicotinamide-adenine dinucleotide (NAD). | |||
T5S2358 | Dehydrocorydaline | Dehydrocorydalin,13-Methylpalmatine | BCL , PARP , p38 MAPK , Caspase , Parasite , Autophagy |
1. Dehydrocorydaline (13-Methylpalmatine) exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSC-LC cells. 2. Dehydrocorydaline stimulates p38 MAPK activation, which can enhance heterodimeriz... | |||
T3S0156 | Atractyloside potassium salt | Atractyloside Dipotassium Salt | Others |
1. Atractyloside potassium salt (Atractyloside Dipotassium Salt) inhibits oxidative phosphorylation by blocking the transfer of adenosine nucleotides through the mitochondrial membrane. | |||
T6780 | Benzamide | Amid kyseliny benzoove,Phenylcarboxyamide,Benzoylamide | PARP , Endogenous Metabolite |
Benzamide (Amid kyseliny benzoove), an inhibitor of poly(ADP-ribose) polymerase, is a derivative of benzoic acid. | |||
T2S2362 | Dehydrocorydaline nitrate | BCL , Others , PARP , p38 MAPK , Caspase , Parasite , Autophagy | |
1. Dehydrocorydaline(DHC) not only inhibits antibody-mediated allergic reactions but also influences cell-mediated allergic reactions, and the inhibitory effect of Corydalis Tuber on allergic reactions may be partially a... | |||
T10990 | Dehydrocorydaline chloride | 13-Methylpalmatine chloride | BCL , PARP , p38 MAPK , Caspase , Parasite , Autophagy |
Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid with anti-inflammatory and anti-cancer activity. Can improve the activation of p38 MAPK. | |||
TN2883 | 3',4'-Dimethoxyflavone | Others , PARP | |
3',4'-Dimethoxyflavone is a standard compound of flavonoids with numerous medicinal activities. | |||
T5S1805 | 5,7-Dihydroxychromone | 5,7-Dihydroxy-4H-Chromen-4-One | Others , Virus Protease , PARP , Caspase , Nrf2 |
1. 5,7-Dihydroxychromone (5,7-Dihydroxy-4H-Chromen-4-One) isolated from DME is one of the active compounds that may contribute to regulate blood glucose levels. 2. 5,7-Dihydroxychromone exerts neuroprotective effect agai... | |||
T8296 | 5,7,4'-Trimethoxyflavone | 4',5,7-Trimethoxyflavone | Apoptosis , PARP , Caspase |
5,7,4'-Trimethoxyflavone (4',5,7-Trimethoxyflavone) is isolated from Kaempferia parviflora (KP) which is a medicinal plant from Thailand. | |||
T2851 | Daphnetin | 7,8-Dihydroxycoumarin,Daphnetol | EGFR , PKA , PKC , Parasite , Autophagy |
Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM), and PKC (IC50: 25.01 μM), also exhibit anti-oxidant and anti-... | |||
T4085 | Paris saponin VII | Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII | Apoptosis , BCL , Others , PARP , p38 MAPK , Akt , Caspase , P-gp , Autophagy |
Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation. | |||
TN6732 | Oenothein B | Apoptosis , HCV Protease , Antibacterial , Antifungal | |
Oenothein B is a specific inhibitor of poly(ADP-ribose) glycohydrolase. Oenothein B shows antioxidant, anti-inflammatory, antifungal, anti-HCV, and antitumor properties. | |||
T22446 | NADP disodium salt | Disodium NADP,Triphosphopyridine nucleotide disodium salt | Others |
NADP disodium salt (Disodium NADP) is a nicotinamide adenine dinucleotide. NADP disodium salt is a key redox cofactor for electron transfer in the metabolism, serves as an electron carrier in a number of reactions, being... | |||
T8170 | Carboxyatractyloside | Gummiferin,Carboxyatractyloside tripotassium salt | Others |
Carboxyatractyloside (Carboxyatractyloside tripotassium salt) is a natural product. It acts as an inhibitor of ADP/ATP carrier, inhibits mitochondrial ADP/ATP transport. | |||
T6942 | Picolinamide | 2-Pyridinecarboxamide,2-Carbamoylpyridine,2-Picolinamide,Picolinoylamide | PARP |
Picolinamide (Picolinoylamide) is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells. | |||
T4888 | Phosphocreatine disodium hydrate | Phosphocreatine disodium salt hydrate | Others , Endogenous Metabolite |
Phosphocreatine disodium hydrate ishigh-energy phosphate reservoir in vertebrate and some invertebrate muscle; provides phosphate for ADP-ATP conversion | |||
T3781 | Jujuboside B | Others | |
Jujuboside B has potent inhibitory effects on collagen-, thrombin-, AA-, and ADP-induced aggregation, and also exhibits superior protection on the thromboembolic model. | |||
T40834 | 5-Hydroxymethyl-2'-deoxycytidine | 5hmdC | PARP |
5-Hydroxymethyl-2'-deoxycytidine is an oxidized derivative of 5-methyl-2'-deoxycytidine (5-mdC) in DNA, causing DNA damage reactions, chromosomal aberrations, replication fork damage, and loss of cell viability.5-Hydroxy... | |||
T2860 | Vanillyl Alcohol | 4-Hydroxy-3-methoxybenzenemethanol,3-Methoxy-4-hydroxybenzyl alcohol,4-Hydroxy-3-methoxybenzyl alcohol,Vanillin alcohol,Vanillic alcohol | Apoptosis , Others |
Vanillyl Alcohol (3-Methoxy-4-hydroxybenzyl alcohol) possesses anti-angiogenic, anticonvulsive, anti-inflammatory, anti-oxidant, neuroprotective, and anti-nociceptive activities. Vanillyl alcohol can effectively inhibit ... | |||
T4786 | D-Ribose(mixture of isomers) | D-Ribose,D-(-)-Ribose | Others , Endogenous Metabolite |
D-Ribose(mixture of isomers) (D-(-)-Ribose), commonly referred to as simply ribose, is a five-carbon sugar found in all living cells. Ribose is not an essential nutrient because it can be synthesized by almost every tiss... | |||
T5S0896 | Loureirin A | Akt , PI3K | |
Loureirin A has an inhibitory effect on platelet activation, perhaps through an impairment of PI3K/Akt signaling.Loureirin A negatively affects agonist-induced platelet aggregation such as collagen, collagen-related pept... | |||
T6S2391 | L-Chicoric Acid | (-)-Chicoric acid,trans-Caffeoyltartaric acid,Chicoric acid,dicaffeoyltartaric acid | Others , HIV Protease |
L-Chicoric Acid (trans-Caffeoyltartaric acid) has been shown to inhibit hyaluronidase and HIV-1 integrase, and to possess phagoeytosis stimulatory activity in vitro and in vivo and antiviral acitivy. L-Chicoric acid may ... | |||
T7982 | 3,6-Dihydroxyflavone | Others | |
3,6-Dihydroxyflavone suppresses the epithelial-mesenchymal transition in breast cancer cells by inhibiting the Notch signaling pathway. | |||
T4883 | Creatine | Methylguanidoacetic acid | Endogenous Metabolite |
Creatine (Methylguanidoacetic acid) is an amino acid that occurs in vertebrate tissues and in urine. In muscle tissue, creatine generally occurs as phosphocreatine. Creatine is excreted as creatinine in the urine. Creati... | |||
T7032 | Eupatorin | Others , P450 | |
Eupatorin has antiproliferative and antiangiogenic effects. Eupatorin has antiproliferative and cytostatic effects on MDA-MB-468 human breast cancer cells due to CYP1-mediated metabolism. Eupatorin-induced cell death is ... | |||
T15721 | Latrunculin A | LAT-A | Others |
Latrunculin A is a toxin isolated from the red sea sponge Latrunculia magnifica. Latrunculin A binds to actin monomers and it also inhibits polymerization of actin (Kds: 0.1, 0.4, 4.7 μM, and 0.19 μM for ATP-actin, ADP-P... | |||
TN3069 | 4beta-Carboxy-19-nortotarol | NADPH-oxidase | |
4 beta-Carboxy-19-nortotarol can inhibit microsomal lipid peroxidation induced by Fe(III)-ADP/NADPH and mitochondrial lipid peroxidation induced by Fe(III)-ADP/ NADH, it inhibits linoleic acid autoxidation but not genera... | |||
T25211 | CC 1014 | CC1014,CC-1014,NSC-356885,NSC356885,NSC 356885 | |
CC 1014 is a polypeptide antibiotic isolated from Penicillium lilacinum that inhibits phosphorylation of ADP, Mg ATPase. | |||
T17273 | YM-254890 | Others | |
YM-254890 inhibits platelet aggregation induced by ADP by blocking the P2Y1 signal transduction pathway (IC50: below 0.6 μM). YM-254890 is a selective Gαq/11 protein inhibitor. YM-254890 displays no inhibition of other G... | |||
T83460 | 11-O-β-D-glucopyranosyl thamnosmonin | ||
11-O-β-D-glucopyranosyl thamnosmonin is a coumarin glucoside extractable from the roots of Angelica apaensis that exhibits weak inhibitory effects on rabbit platelet aggregation induced by PAF, AA, and ADP [1]. | |||
TN1309 | 6-Hydroxykaempferol-3,6,7-triglucoside | Others | |
6-Hydroxykaempferol 3,6,7-tri-O-glucoside and 6-hydroxykaempferol 3,6-di-O-glucoside can inhibit platelet aggregation induced by collagen, they also show weak inhibitory effects on the adenosine 5'-diphosphate (ADP)- ind... | |||
T37714 | Fuscin | ||
Fuscin is a quinonoid fungal metabolite originally isolated from O. fuscum that has diverse biological activities. It inhibits binding of the ADP/ATP translocase inhibitor atractyloside to rat liver mitochondria in an AD... | |||
TN1310 | 6-Hydroxykaempferol 3,6-diglucoside | Others | |
6-Hydroxykaempferol 3,6-di-O-glucoside and 6-hydroxykaempferol 3,6,7-tri-O-glucoside can inhibit platelet aggregation induced by collagen, they also show weak inhibitory effects on the adenosine 5'-diphosphate (ADP)- ind... | |||
T38015 | Herquline A | ||
Herquline A is an alkaloid fungal metabolite originally isolated from P. herquei. It inhibits cell death induced by influenza A strain A/PR/8/34 in MDCK cells with an IC50 value of 10 μg/ml and inhibits viral replication... | |||
TN6924 | Anhydrosafflor yellow B | (2S,3S)-6,7-dihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-2-[(1S,2R,3R)-1,2,3,4-tetrahydroxybutyl]-3-{2,3,4-trihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-6-oxo-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]cyclohexa-1,4-dien-1,AHSYB | Others |
Anhydrosafflor yellow B ((2S,3S)-6,7-dihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-2-[(1S,2R,3R)-1,2,3,4-tetrahydroxybutyl]-3-{2,3,4-trihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-6-oxo-3-[(2R,3R,4S,5S,6R)-3,4,... | |||
TN6014 | Norcepharadione B | ||
Norcepharadione B shows good inhibitory activity against the replication of HSV-1, it also shows antimalarial activity with EC50 values of 7.5mug/ml. Norcepharadione B exhibits significant cytotoxicity against five human... | |||
TN4046 | Excisanin A | MMP , FAK , PARP , GSK-3 , NF-κB , Wnt/beta-catenin , Akt , Caspase , PI3K , Prostaglandin Receptor , JNK | |
ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a potential anti-metastatic chemotherapeutic agent for the treatm... | |||
TN4664 | Norarmepavine | Others | |
N-norarmepavine shows significant cytotoxic activities against HL-60 carcinoma cell line with inhibitory ratios of 51.43% at concentration of 1 x 10(-5) M. Norarmepavine shows inhibition against Trypanosoma cruzi. D-(+)-... | |||
T73403 | Aviculin | ||
Aviculin, a lignan glycoside, exhibits significant anticancer properties, particularly in inhibiting the metabolic activity of MCF-7 cells to below 50%, with an IC 50 value of 75.47 μM. It promotes apoptosis in breast ca... | |||
T35624 | Ajoene | ||
Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities, including antibacterial, anticancer, antiplatelet, and antioxidant properties.1,2,3,4It is active against Gram-positive (MICs =... |
カタログ番号 | 製品名 | Species | Expression System |
---|---|---|---|
TMPY-01188 | PARP Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
PARP Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 114.5 kDa and the accession number is A0A024R3T8. | |||
TMPY-03796 | ARF3 Protein, Human, Recombinant (His) | Human | E. coli |
ARF3, also known as ADP-ribosylation factor 3, belongs to the RAS superfamily. Members of this family include ARF1, ARF2, ARF3, ARF4, ARF5 and ARF6. ARF3 gene is a member of the human ARF gene family. These genes encode ... | |||
TMPY-04209 | ART1 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
ART1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31.7 kDa and the accession number is A0A2K5WCR3. | |||
TMPJ-00190 | CD38 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
CD38, also called ADP-ribosyl cyclase, is a Type II integral membrane protein with 301 amino acids in length that belongs to the ADP-ribosyl cyclase family.It synthesizes the second messagers cyclic ADP-ribose and nicoti... | |||
TMPY-03386 | ART3 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
ART3 is an arginine-specific ADP-ribosyltransferase which belongs to the Arg-specific ADP-ribosyltransferase family. ART3 catalyzes a reversible reaction which modifies proteins by the addition or removal of ADP-ribose t... | |||
TMPY-00583 | ADPRH Protein, Human, Recombinant (His) | Human | E. coli |
Cholera toxin (CT) produced by Vibrio cholerae causes the devastating diarrhea of cholera by catalyzing the ADP-ribosylation of the alpha subunit of the intestinal Gs protein (Gsalpha), leading to characteristic water an... | |||
TMPY-03868 | ARF5 Protein, Human, Recombinant (His) | Human | E. coli |
ARF5, also known as ADP-ribosylation factor 5, belongs to the small GTPase superfamily, Arf family. Members of this family stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular traff... | |||
TMPJ-00202 | CD157 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
The cluster of differentiation (CD) system is a glycosyl phosphatidylinositol anchored membrane protein that belongs to the CD38 family.It is generally used in immunophynotyping. CD157 was discovered in a bone marrow str... | |||
TMPY-04130 | ARF1 Protein, Human, Recombinant (His) | Human | E. coli |
ARF1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 22.5 kDa and the accession number is P84077. | |||
TMPY-06746 | ARF1 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | E. coli |
ARF1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in E. coli expression system with His and Avi tag. The predicted molecular weight is 23.33 kDa and the accession number is P84077. | |||
TMPY-06637 | ARF1 Protein, Human, Recombinant (GST) | Human | E. coli |
ARF1 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with GST tag. The predicted molecular weight is 47.00 kDa and the accession number is P84077. | |||
TMPY-03312 | ART4/CD297 Protein, Rat, Recombinant (His) | Rat | HEK293 Cells |
ART4/CD297 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.4 kDa and the accession number is F1MA10. | |||
TMPY-03777 | ART4/CD297 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
ART4/CD297 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 29.1 kDa and the accession number is G7PJY0. | |||
TMPY-03544 | ART4/CD297 Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 Cells |
ART4/CD297 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 54.7 kDa and the accession number is G7PJY0. | |||
TMPY-01620 | MDGA2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
MAM domain-containing glycosylphosphatidylinositol anchor protein 2, also known as MAM domain-containing protein 1, MDGA2, and MAMDC1, is a cell membrane protein that contains six Ig-like (immunoglobulin-like) domains an... | |||
TMPH-03026 | CARDS Protein, Mycoplasma pneumoniae, Recombinant (His & Myc) | Mycoplasma pneumoniae | E. coli |
Acts as an ADP-ribosylating toxin, which may transfer the ADP-ribosyl group from NAD(+) to specific amino acids in target proteins. Elicits cytopathic effects in mammalian cells, such as disorganization and disruption of... | |||
TMPH-00432 | Diphtheria toxin Protein, Corynephage omega, Recombinant (His & Myc) | Corynephage omega | E. coli |
Diphtheria toxin Protein, Corynephage omega, Recombinant (His & Myc) is expressed in E. coli. | |||
TMPY-06532 | ART1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
ART1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31.55 kDa and the accession number is NP_004305.2. | |||
TMPY-03500 | ARL2BP Protein, Human, Recombinant (His) | Human | E. coli |
ADP-ribosylation factor (ARF)-like proteins (ARLs) comprise a functionally distinct group of the ARF family of RAS-related GTPases. ARL2BP binds to ARL2.GTP with high affinity but does not interact with ARL2.GDP, activ... | |||
TMPY-02738 | ART4/CD297 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
ART4/CD297 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.2 kDa and the accession number is EDL10575.1. | |||
TMPY-02822 | ART4/CD297 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
ART4/CD297 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 53.7 kDa and the accession number is Q9CRA0. | |||
TMPY-00344 | ARL6IP6 Protein, Human, Recombinant (mFc) | Human | HEK293 Cells |
It had been found that a homozygous truncating mutation in ARL6IP6 as the likely cause of a syndromic form of CMTC associated with major dysmorphism, developmental delay, transient ischemic attacks and cerebral vascular ... | |||
TMPY-02465 | PARP Protein, Mouse, Recombinant (His) | Mouse | Baculovirus Insect Cells |
PARP Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 115 kDa and the accession number is Q921K2. | |||
TMPY-02421 | PARP3 Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells |
Poly(ADP-ribose) polymerase 3 (PARP3) is an important member of the PARP family and shares high structural similarities with both PARP1 and PARP2. Poly(ADP-ribose) polymerase 3 (PARP3), a critical player in cellular resp... | |||
TMPH-00553 | Fructose 5-dehydrogenase [NADP(+)] Protein, Erwinia citreus, Recombinant (His & KSI) | Erwinia citreus | E. coli |
Fructose 5-dehydrogenase [NADP(+)] Protein, Erwinia citreus, Recombinant (His & KSI) is expressed in E. coli. | |||
TMPH-01743 | NADP-ME Protein, Human, Recombinant (His) | Human | E. coli |
NADP-ME Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 67.2 kDa and the accession number is Q16798. | |||
TMPH-03283 | CD39 Protein, Rat, Recombinant (His) | Rat | Baculovirus Insect Cells |
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP.... | |||
TMPH-01879 | PARP11 Protein, Human, Recombinant (His) | Human | E. coli |
Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis. PARP11 Protein, Human, Recombinant (His) is exp... | |||
TMPH-03284 | CD39 Protein, Rat, Recombinant (E. coli, His) | Rat | E. coli |
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP.... | |||
TMPH-01822 | P2Y1 Protein, Human, Recombinant (His) | Human | E. coli |
Receptor for extracellular adenine nucleotides such as ADP. In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately p... | |||
TMPH-00207 | PTX S1 Protein, Bordetella pertussis, Recombinant (His) | Bordetella pertussis | P. pastoris (Yeast) |
S1 is an NAD-dependent ADP-ribosyltransferase, which plays a crucial role in the pathogenesis of B.pertussis causing disruption of normal host cellular regulation. It catalyzes the ADP-ribosylation of a cysteine in the a... | |||
TMPH-01091 | CHD1L Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catal... | |||
TMPH-03168 | Exotoxin A Protein, Pseudomonas aeruginosa, Recombinant (His & KSI) | Pseudomonas aeruginosa | E. coli |
An NAD-dependent ADP-ribosyltransferase (ADPRT). Catalyzes the transfer of the ADP ribosyl moiety of oxidized NAD (NAD(+)) onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis. Has an LD(50) of 65... | |||
TMPH-00689 | Propionate kinase Protein, E. coli O6:H1, Recombinant (His & Myc) | E. coli | E. coli |
Catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. Propionate kinase Protein, E. coli O6:H1, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The ... | |||
TMPH-03194 | GCK Protein, Pyrococcus horikoshii, Recombinant (His & Myc) | Pyrococcus horikoshii | E. coli |
Catalyzes the ATP-dependent phosphorylation of D-glycerate to 2-phosphoglycerate. It can also utilize GTP, CTP, UTP, ADP or pyrophosphate as phosphate donor. GCK Protein, Pyrococcus horikoshii, Recombinant (His & Myc) is... | |||
TMPH-00863 | 5-oxoprolinase/OPLAH Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. 5-oxoprolinase/OPLAH Protein, Human, Recombinant (His & Myc) is expressed in E. coli expressi... | |||
TMPJ-00384 | PFKM Protein, Human, Recombinant (His) | Human | HEK293 Cells |
6-phosphofructokinase, muscle type is a muscle-type isozyme that in humans is encoded by the PFKM gene. It belongs to the phosphofructokinase family and Two domains subfamily. PFKM functions as subunits of the mammalian ... | |||
TMPY-04480 | UMP-CMP kinase/CMPK1 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
CMPK1 plays a key role in the maintenance of pyrimidine nucleotide pool profile and for the metabolism of pyrimidine analogs in cells. It catalyzes the phosphoryl transfer from ATP to UMP, CMP, and deoxy-CMP (dCMP), re... | |||
TMPH-00213 | Disintegrin batroxostatin Protein, Bothrops atrox, Recombinant (His & Myc) | Bothrops atrox | E. coli |
Inhibits fibrinogen interaction with platelets. Acts by binding to the glycoprotein IIb-IIIa receptor (ITGA2B/ITGB3) on the platelet surface and inhibits aggregation induced by ADP, thrombin, platelet-activating factor a... | |||
TMPY-04762 | CKM Protein, Human, Recombinant (His) | Human | E. coli |
CKM, also known as CK-MM, is mainly expressed in skeletal muscle. As the primary CK isoenzyme, it also can be detected in heart muscle. CKM is a subunit of creatine kinase (CK). CK is an enzyme expressed by various tissu... | |||
TMPJ-00297 | SHPK Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Sedoheptulokinase (SHPK) belongs to the FGGY kinase family, and is mainly located in cytoplasm. SHPK is strongly expressed in liver, kidney and pancreas. It is expressed at lower levels in placenta and heart, and very we... | |||
TMPY-04479 | PFKM Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells |
PFK1, also known as PFKM, is a regulatory glycolytic enzyme. PFK1 converts fructose 6-phosphate and ATP into fructose 1,6-bisphosphate (through PFK-1), fructose 2,6-bisphosphate (through PFK-2) and ADP. It is a muscle-ty... | |||
TMPH-00217 | SVMP Protein, Bothrops leucurus, Recombinant (His & Myc) | Bothrops leucurus | E. coli |
Non-hemorrhagic metalloproteinase that hydrolyzes the alpha chains of fibrinogen, as well as fibrin, fibronectin and casein. Beta and gamma chains are also hydrolyzed, but more slowly. Thrombolytic activity is also obser... | |||
TMPY-03406 | NMNAT1 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
NMNAT, also known as NMNAT1, is a member of the Nicotinamide-nucleotide adenylyltransferases. It is widely expressed with high levels in skeletal muscle, heart, liver, and kidney. NMNAT appears to have the ability to pro... | |||
TMPJ-00682 | CD39L1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
CD39L1 protein (ENTPD2 or NTPDase2) is a member of the ecto-nucleoside triphosphate diphosphohydrolase family which the main role is termination of purinergic signaling. CD39L1 gene encodes a precursor protein with 495 a... | |||
TMPY-03849 | NUDT5 Protein, Human, Recombinant (His) | Human | E. coli |
NUDT5 (Nudix Hydrolase 5) is a Protein Coding gene. This gene belongs to the Nudix (nucleoside diphosphate linked moiety X) hydrolase superfamily. The encoded enzyme catalyzes the hydrolysis of modified nucleoside diphos... | |||
TMPY-04761 | Creatine kinase B Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
CKB(Creatine kinase B type) contains 1 phosphagen kinase C-terminal domain and 1 phosphagen kinase N-terminal domain. It belongs to the ATP:guanido phosphotransferase family. CKB consists of a homodimer of two identical... | |||
TMPH-02530 | ATP5B Protein, Mouse, Recombinant (His & Myc & SUMO) | Mouse | E. coli |
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respirator... | |||
TMPY-02831 | Caspase-7 Protein, Human, Recombinant (His) | Human | E. coli |
Caspase 7, also known as caspase-7 and MCH3, belongs to the cysteine-aspartic acid protease (caspase) family. Caspases play a role in the signal transduction pathways of apoptosis, necrosis and inflammation. There are tw... | |||
TMPY-04473 | ADK Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells |
Adenosine kinase(ADK) belongs to the family of transferases. Adenosine kinase (ADK) is the key enzyme in adenosine metabolism and catalyzes ATP and adenosine into two products: ADP and AMP. Two isoforms of the enzyme ade... | |||
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カタログ番号 | 製品名 | ||
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L1120 | AMPK-Targeted Compound Library | 80 compounds | |
80 well-chosen unique AMPK-targeted small molecules; | |||
L3500 | Histone Modification Compound Library | 469 compounds | |
A unique collection of 469 histone modification related compounds for high throughput screening (HTS) and high content screening (HCS); | |||
L8300 | Chromatin Modification Compound Library | 250 compounds | |
A unique collection of 250 compounds targeting chromatin remodeling pathway for high throughput screening (HTS) and high content screening (HCS); |