|
T4425 |
JK-P3
|
|
VEGFR
|
|
JK-P3 is a pyrazole-based inhibitor of VEGFR-2 (IC50: 7.8 μM). JK-P3 inhibits FGFR 1/3 kinase activity in vitro, but has no effect on FGFR signaling in cell-based assays. The compound blocks wound healing and tube format... |
|
T6207 |
SC144
|
|
Apoptosis
,
Interleukin
|
|
SC144 is an orally active small-molecule gp130 inhibitor. |
|
T6540 |
Ibuprofen Lysine
|
Neoprofen |
COX
|
|
Ibuprofen Lysine (Neoprofen) is a non-steroidal anti-inflammatory drug. |
|
T1394 |
Ibuprofen
|
Brufen,(±)-Ibuprofe,Motrin,Advil |
COX
|
|
Ibuprofen (Advil) is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resu... |
|
T23127 |
PD-161570
|
PD 161570 |
EGFR
,
FGFR
,
PDGFR
,
Src
|
|
PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM. PD-161570 also inhibits the PDGFR, EGFR and c-Src tyrosine kinases with IC50 values of 310 nM, 240 nM, a... |
|
T0314 |
Hexylresorcinol
|
4-Hexylresorcinol |
Apoptosis
,
Tyrosinase
,
Antibacterial
,
Parasite
|
|
Hexylresorcinol (4-Hexylresorcinol) is a substituted dihydroxybenzene used topically as an antiseptic for the treatment of minor skin infections. |
|
T2690 |
Tranilast
|
MK 341,SB 252218 |
RAAS
,
Prostaglandin Receptor
|
|
Tranilast (SB 252218), an antiallergic drug, suppresses lipid mediator and cytokine release from inflammatory cells, therefore utilized in the treatment of allergic disorders. |
|
T35570 |
Chiauranib
|
CS2164 |
c-Fms
,
VEGFR
,
FLT
,
PDGFR
,
c-Kit
,
Aurora Kinase
|
|
Chiauranib is a multi-target inhibitor against tumor angiogenesis and exhibits potent anticancer effects. Chiauranib potently inhibits the angiogenesis-related kinases (VEGFR1, VEGFR2, VEGFR3, PDGFRα and c-Kit), mitosis-... |
|
T9127 |
MYLS22
|
|
Others
|
|
MYLS22 is a first-in-class and selective inhibitor of optic atrophy 1 (OPA1) . MYLS22 can target endothelial OPA1 to curtail tumor growth and inhibits angiogenesis by impinging on NFkB activity and on angiogenic gene exp... |
|
T24997 |
ABT-510 acetate
|
ABT 510 acetate |
Apoptosis
|
|
ABT-510 acetate is an endogenous anti-angiogenic TSP peptide inhibitor, a thrombospondin analog, with anti-inflammatory, anti-cancer and anti-angiogenic activity that induces apoptosis and inhibits ovarian tumor growth i... |
|
T28077 |
MMPP
|
|
VEGFR
,
STAT
|
|
MMPP is a novel VEGFR2 inhibitor with anti-inflammatory and potential anticancer activity, inhibits STAT3, inhibits angiogenesis via VEGFR2/AKT/ERK/NF-kappaB pathway, and can be used to alleviate myocardial injury. |
|
T67746 |
IMS2186
|
|
Others
|
|
IMS2186 is a reagent with activity of antichoroidal neovascularization (CNV). IMS2186 could arrest cancer cell cycle in G2/M phase, result in exerting anti-proliferation and anti-angiogenesis effects. IMS2186 reduces the... |
|
T79860 |
TIE-2/VEGFR-2 kinase-IN-5
|
|
VEGFR
,
Tie-2
|
|
TIE-2/VEGFR-2 kinase-IN-5 is a potent TIE-2 and VEGFR-2 tyrosine kinase receptor inhibitor with anti-angiogenic activity and is commonly used in biomedical research related to angiogenesis. |
|
T60839 |
SLMP53-1
|
|
p53
|
|
SLMP53-1 is a p53 activator with anti-tumor activity, inhibits wt and mutp53, activates reprogramming of glucose metabolism in xenografted human tumor tissues, and interferes with angiogenesis and migration. SLMP53-1 inh... |
|
T8554 |
KCC-07
|
|
DNA Alkylator/Crosslinker
|
|
KCC-07 is a selective, potent and brain-penetrant inhibitor of methyl-CpG-binding domain protein 2(MBD2) with anticancer activity. KCC-07 prevents binding of MBD2 to methylated DNA and activates brain specific angiogenes... |
|
T1574 |
Etoricoxib
|
Arcoxia,MK-663,Tauxib,L-791456,Nucoxia,Desvenlafaxine |
COX
|
|
Etoricoxib (MK-663) is a synthetic, nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic, and potential antineoplastic properties. Etoricoxib specifically binds to and inhibits the enzyme cyclooxygenas... |
|
T0153 |
Oltipraz
|
NSC 347901,RP 35972 |
HIF/HIF Prolyl-Hydroxylase
,
HIV Protease
,
Reverse Transcriptase
,
Nrf2
,
HIF
|
|
Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes, such as glutathione S transferase (GST) and NAD(P)H: quin... |
|
T1185 |
Rofecoxib
|
MK 966,MK-0966 |
COX
|
|
Rofecoxib (MK 966) binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in an inhibition of the conversion of arachidonic acid to prostaglandins. Rofecoxib is a synthetic, nonsteroidal derivative of pheny... |
|
T24858 |
TBZ-07
|
|
|
|
TBZ-07 is an anti-angiogenesis and vascular disrupting agent that acts by exhibiting moderate inhibitory cell proliferation activity. |
|
TP2468 |
PNU-145156E (FCE26644)
|
FCE 26644,FCE26644,PNU-145156E,PNU145156E,FCE-26644,PNU 145156E |
|
|
PNU-145156E (FCE26644) a novel angiogenesis inhibitor, has been shown to block circulating angiogenesis promoting growth factor in animal studies and has shown anti-tumor effects in solid tumors in mice. |
|
T12650 |
R916562
|
|
TAM Receptor
|
|
|
|
T35492 |
(±)10(11)-DiHDPA
|
|
|
|
(±)10(11)-DiHDPA is produced from cytochrome P450 epoxygenase action on docosahexaenoic acid . It has been shown to inhibit VEGF-induced angiogenesis in mice and may have additional anti-inflammatory and anti-tumor effec... |
|
T11260 |
FAK inhibitor 2
|
|
FAK
|
|
FAK inhibitor 2, antitumor and anti-angiogenesis activitiesis ,is a potent focal adhesion kinase (FAK) inhibitor with an IC50 of 0.07 nM . |
|
T82401 |
Fibulostatin 6.3
|
|
|
|
Fibulostatin 6.3 is an anti-angiogenic peptide utilized in research related to angiogenesis inhibition [1]. |
|
T81549 |
Papilostatin-2
|
|
|
|
Papilostatin-2 is an anti-angiogenic peptide utilized for research purposes in the study of angiogenesis inhibition [1]. |
|
T83170 |
Adamtsostatin 4
|
|
|
|
Adamtsostatin 4, an anti-angiogenic peptide, is utilized in research related to angiogenesis inhibition [1]. |
|
T61962 |
PARP-1/HDAC-IN-1
|
|
|
|
PARP-1/HDAC-IN-1 is an effective dual inhibitor of PARP-1/HDAC6, with IC50 of 68.90 nM and 510 nM respectively. PARP-1/HDAC-IN-1 has anti-cancer, anti-migration and anti-angiogenesis activities. |
|
T82776 |
Cartilostatin 1
|
|
|
|
Cartilostatin 1, an anti-angiogenic peptide, has potential applications in research focused on angiogenesis inhibition [1]. |
|
T61190 |
Tubulin inhibitor 27
|
|
|
|
Tubulin Inhibitor 27 (DYT-1), a compound that inhibits tubulin polymerization with an IC50 of 25.6 μM, exhibits anti-angiogenesis and antitumor activities [1]. |
|
T76697 |
Panitumumab (anti-EGFR)
|
|
|
|
Panitumumab, a fully human IgG2 anti-EGFR monoclonal antibody, exerts anti-tumor effects by inhibiting tumor cell proliferation, survival, and angiogenesis. It is utilized in researching various cancers, including colon ... |
|
T70018 |
Apricoxib
|
|
|
|
Apricoxib, also known as Benzenesulfonamide 42(4ethoxyphenyl)4methyl1Hpyrrol1yl, is an orally bioavailable nonsteroidal anti-inflammatory agent (NSAID) with potential antiangiogenic and antineoplastic activities. Apricox... |
|
T75667 |
Neamine
|
|
|
|
Neamine, a broad-spectrum aminoglycoside antibiotic derived from Neomycin, exhibits potent antibacterial, antitumor, and neuroprotective activities. As an anti-angiogenesis agent, it specifically targets angiogenin [1] [... |
|
T62922 |
Tubulin inhibitor 25
|
|
|
|
Tubulin inhibitor 25 is a potent inhibitor of tubulin (IC50: 0.98 μM) and significantly inhibits HT29 cells. tubulin inhibitor 25 inhibits cell migration and microtubule formation and contributes to anti-angiogenesis. |
|
T68406 |
A-849519
|
|
|
|
A-849519 is a reversible inhibitor of MetAP2 that has demonstrated anti-angiogenesis and anticancer activity in a number of in vitro and in vivo models. In this study, we evaluated the anticancer activity of A-849519 in ... |
|
T78064 |
Synstatin (92-119)
|
SSTN92-119 |
Integrin
|
|
Synstatin (92-119) serves as an anti-tumor agent by suppressing angiogenesis and cancer cell invasion, chiefly through the down-regulation of integrin αvβ3 and attenuation of angiogenic growth factor activation, specific... |
|
T74118 |
Roxatidine
|
|
|
|
Roxatidine, the active metabolite of Roxatidine acetate hydrochloride, serves as a histamine H2-receptor antagonist and exhibits anti-ulcer properties. It functions by suppressing the release of histamine, thereby inhibi... |
|
T79699 |
anti-TNBC agent-2
|
|
Apoptosis
|
|
Anti-TNBC agent-2 (3j), a purine derivative, acts as an anti-triple negative breast cancer (TNBC) therapeutic. It promotes apoptosis in MDA-MB-231 cells, while also inhibiting their migration and angiogenesis. Moreover, ... |
|
T76954 |
Vulinacimab
|
|
|
|
Vulinacimab (HLX-06), an anti-VEGFR-2 monoclonal antibody (mAb), plays a pivotal role in cancer research due to VEGFR-2's significant involvement in angiogenesis, as well as the proliferation, survival, migration, and di... |
|
T68546 |
PF-00337210
|
|
|
|
PF-00337210 is an orally available ATP-competitive inhibitor of the vascular endothelial growth factor receptor type 2 (VEGFR2), with potential anti-angiogenesis and antineoplastic activities. Upon administration, the VE... |
|
T81125 |
Sotiburafusp alfa
|
|
VEGFR
|
|
Sotiburafusp alfa is a humanized bispecific fusion protein comprising a VEGFR-1 extracellular domain fragment (129-228, 1-100 in the current sequence) connected through a 101 GGSGGSGGSGGSGGS 115 peptide linker to the N-t... |
|
T60292 |
Ibuprofen sodium
|
|
|
|
Ibuprofen ((±)-Ibuprofen) sodium is an orally active, selective inhibitor of COX-1 (IC 50 = 13 μM). Ibuprofen sodium inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen sodium is a nonsteroid... |
|
T76895 |
Abicipar pegol
|
|
|
|
Abicipar pegol (AGN-150998, MP0112), an anti-VEGF DARPin molecule, represents a novel class of small ankyrin repeat domain-containing proteins designed for high specificity and affinity targeting. This compound is adept ... |
|
T36408 |
Rhein-13C4
|
Rhein-13C4 |
|
|
Rhein-13C4 is intended for use as an internal standard for the quantification of rhein by GC- or LC-MS. Rhein is an anti-inflammatory anthraquinone found in rhubarb and is the bioactive derivative of its prodrug diacerei... |
|
T71082 |
DW532
|
|
|
|
DW532 is one of simplified analogues of hematoxylin that has shown broad-spectrum inhibition on tyrosine kinases and in vitro anti-cancer activities. DW532 inhibited EGFR and VEGFR2 in vitro kinase activity (the IC50 val... |
|
T35578 |
Phosphatidylserines (sodium salt)
|
Phosphatidylserines (sodium salt),L-α-Phosphatidylserine |
|
|
Phosphatidylserine is a naturally occurring phospholipid that comprises 2-10% of total phospholipids in mammals and is enriched in the central nervous system, particularly the retina. It is anionic and found mainly on th... |
