| T2230 |
Paeoniflorin
|
Peoniflorin |
HSP
,
COX
|
|
Paeoniflorin (Peoniflorin) is a herbal constituent extracted from the root of Paeonia albiflora Pall. |
| T5S0106 |
Peimisine
|
Ebeiensine |
RAAS
,
AChR
|
|
1. Peimisine (Ebeiensine) can affect M-receptor, excit β-receptor, restrain the release of internal calcium, and promote to releaseing nitrogen monoxidum in order to relax tracheal smooth muscle and relieve asthma. 2. Pe... |
| T5755 |
Aloesin
|
|
Tyrosinase
|
|
Aloesin is a C-glycosylated chromone compound found in aloe (Liliaceae) that inhibits tyrosinase (IC50 = 0.9 mM), an enzyme responsible for catalyzing the first step of the conversion of tyrosine to melanin. |
| T4853 |
TRIA-662
|
3-Carbamoyl-1-methylpyridinium Chloride,1-Methylnicotinamide chloride,1-methylpyridin-1-ium-3-carboxamide hydrochloride,Nicotinamide Chloromethylate |
Others
,
Endogenous Metabolite
|
|
TRIA-662 (Nicotinamide Chloromethylate) is a niacin metabolite excreted via the urinary system. |
| T4124 |
IKarisoside A
|
Icarisoside-,Baohuoside II |
NO Synthase
|
|
IKarisoside A(Baohuoside II) is a flavonol glycoside from the Berberidaceae plant Epimedium, with anti-inflammatory activity. |
| T12016 |
Methyl L-pyroglutamate
|
L-Pyroglutamic acid methyl ester,(S)-Methyl 5-oxopyrrolidine-2-carboxylate |
Others
|
|
Methyl L-pyroglutamate (L-Pyroglutamic acid methyl ester) shows anti-inflammatory activity. Methyl L-pyroglutamate is isolated from Portulaca oleracea L.. |
| T2875 |
Angelicin
|
Isopsoralen |
Apoptosis
,
Virus Protease
,
Antiviral
|
|
Angelicin (Isopsoralen), is a furanocoumarin with anti-Y, antiviral, anti-inflammatory activity. |
| TN1785 |
Isomagnolone
|
|
Others
|
|
Isomagnolone is a natural product isolated from Illicium burmanicum and has anti-inflammatory activity. |
| T3802 |
Ligustroflavone
|
Nuezhenoside |
Others
,
CaSR
|
|
Ligustroflavone (Nuezhenoside) has anti-inflammatory activity. |
| TN5634 |
Aureusidin
|
Auresudidin,Auresidin |
Antioxidant
,
Reactive Oxygen Species
,
Lipoxygenase
|
|
Aureusidin (Auresidin) shows antioxidant and lipoxygenase inhibitory activity with anti-inflammatory effects. |
| T3396 |
Baohuoside I
|
Icariside-II,Icariin-II |
Apoptosis
,
CXCR
|
|
Baohuoside I (Icariside-II) is a component of Epimedium koreanum, exhibits anti-inflammatory activity and anti-osteoporosis activities. |
| T3834 |
8-Epideoxyloganic acid
|
|
ROS
,
Immunology/Inflammation related
|
|
8-Epideoxyloganic acid possesses bioactivities of analgesia, homeostasis and anti-inflammatory. It has the potential to serve as anti-inflammatory agents during oxidative stress, the inhibition of ROS production, possibl... |
| TN1557 |
Decursinol angelate
|
|
ERK
,
VEGFR
,
PKC
,
JNK
|
|
Decursinol angelate has anti-tumor, anti-inflammatory, anti-oxidant, and hepatoprotective activities, it inhibits VEGF-induced angiogenesis via suppression of the VEGFR-2-signaling pathway; it also suppresses invasion an... |
| T3409 |
Plantamajoside
|
Y0160,C10485 |
Others
|
|
Plantamajoside (Y0160) has anti-hepatotoxic, anti-inflammatory, antinociceptive activities, improving sexual function and antioxidant activity. |
| T8213 |
Isolinderalactone
|
|
NOS
,
STAT
|
|
Isolinderalactone shows anti-inflammatory and anticancer capacity, and it exhibits moderate iNOS inhibitory activity, with the IC50 value of 0.30 uM. |
| T6S0630 |
Hypaconitine
|
|
P450
,
TNF
|
|
Hypaconitine, an active and highly toxic constituent derived from Aconitum species, has anti-inflammatory activity, is widely used to treat rheumatism. |
| T8229 |
5,7,3',4'-Tetramethoxyflavone
|
|
Antibacterial
,
Parasite
,
Antifungal
|
|
5,7,3',4'-Tetramethoxyflavone (TMF), a prominent polymethoxyflavone (PMF) derived from M. exotica, displays a range of notable bioactivities. These include anti-malarial, anti-fungal, anti-mycobacterial, and anti-inflamm... |
| T2S0765 |
Epibetulinic acid
|
|
NO Synthase
,
Prostaglandin Receptor
|
|
Epibetulinic acid has anti-inflammatory activity, it exhibits potent inhibitory effects on NO and prostaglandin E(2) production in mouse macrophages (RAW 264.7) stimulated with bacterial endotoxin. |
| TQ0205 |
Procyanidin B1
|
|
TLR
|
|
Procyanidin B1, isolated from commonly eaten fruits, binds to the TLR4/MD-2 complex and has anti-inflammatory activity. |
| TN2010 |
Ombuin
|
|
Antibacterial
|
|
Ombuin has anti-inflammary activity, it inhibits some macrophage functions involved in the inflammatory process. |
| TN1295 |
5-O-Caffeoylshikimic acid
|
|
IL Receptor
,
TNF
,
NO Synthase
|
|
5-O-Caffeoylshikimic acid shows anti-oxidative activity; it also shows anti-inflammatory activity, the underlying mechanism was associated with downregulation of nuclear factor-κB. |
| T6S0413 |
Pectolinarigenin
|
Pectolinaringenin |
Others
,
Lipoxygenase
,
COX
|
|
1. Pectolinarigenin (Pectolinaringenin) exhibits hepatoprotective activity mainly via SOD antioxidant mechanism. 2. Pectolinarigenin possesses anti-inflammatory activity and that they may inhibit eicosanoid formation in ... |
| TN1599 |
Eburicoic acid
|
Eburicoicacid,MFCD00238594,ZINC4655149 |
Antioxidant
,
TNF
,
NOS
,
NO Synthase
,
CCR
,
Immunology/Inflammation related
|
|
Eburicoic acid (ZINC4655149) exhibits anti-inflammatory and antioxidant activity thereby protecting the liver from CCl4-induced hepatic damage and can be used in studies about anti-liver cancer. |
| TN1438 |
Beta-Amyrin acetate
|
|
Antioxidant
,
HMG-CoA Reductase
,
Epoxide Hydrolase
,
Antifungal
|
|
beta-Amyrin acetate inhibits HMG-CoA Reductase (HMGCR) and sEH activity with IC50 of 3.4 μM. beta-Amyrin acetate has anti-inflammatory, antifungal, antioxidant, and anti-hyperlipidemic activities. |
| T6S0117 |
Avicularin
|
Fenicularin |
ERK
|
|
Avicularin (Fenicularin) has anti-allergic, anti-inflammatory, hepatoprotective, antioxidant, anti-tumor and other activities. It ameliorates human hepatocellular carcinoma by modulating the activities of NF-κB(p65), COX... |
| T4S1321 |
(+)-Magnoflorine chloride
|
Magnoflorine chloride,Corytuberine methochloride,Thalictrine chloride,Escholine chloride |
Others
,
Antifungal
|
|
(+)-Magnoflorine chloride (Escholine chloride) has anti-inflammatory activity, it can inhibit inflammations. |
| T3S1320 |
(+)-Magnoflorine iodide
|
Magnoflorine iodide,Thalictrine iodide,Corytuberine Methiodide |
Others
,
Antifungal
|
|
(+)-Magnoflorine iodide (Thalictrine iodide) has anti-inflammatory activity, it can inhibit inflammations. |
| TN6489 |
Regaloside A
|
|
Others
|
|
Regaloside A is a phenylpropane derived from lily of the valley that shows DPPH free radical scavenging activity at 160 ppm.Regaloside A has anti-inflammatory activity and antidepressant activity. |
| T0065 |
Acetaminophen
|
4-Acetamidophenol,4'-Hydroxyacetanilide,APAP,Paracetamol |
COX
,
Endogenous Metabolite
,
Histone Acetyltransferase
|
|
Acetaminophen (APAP) is a COX inhibitor that inhibits COX-1 and COX-2 (IC50=113.7/25.8 μM). Acetaminophen has antipyretic and analgesic activity as well as weak anti-inflammatory activity. |
| T5708 |
LUPENONE
|
|
Phosphatase
,
Parasite
|
|
Lupenone is a natural product isolated from Rhizoma Musae and has good anti-diabetic activity,and has anti-inflammatory activity.lupenone were potent PTP1B inhibitors with IC50 values of 15.11±1.23μM. |
| TQ0118 |
Britannilactone
|
Desacetylinulicin |
Others
|
|
Britannilactone (Desacetylinulicin) is a sesquiterpene from Inula britannica with anti-inflammatory and anti-tumor activity.Britannilactone has been associated with this antimelanotic activity and can be used in studies ... |
| T3770 |
Taraxasterol
|
Taraxasterin |
IL Receptor
,
TNF
,
NO Synthase
,
Prostaglandin Receptor
|
|
Taraxasterol (Taraxasterin) is compound with anti-inflammatory activity. |
| T3821 |
Deapioplatycodin D
|
Deapi-platycodin D,DesapioplatycodinD |
Others
,
HCV Protease
|
|
Deapioplatycodin D and platycodin D can regulate the production and secretion of airway mucin and, at least in part, explains the traditional use of aqueous extract of APG as expectorants in diverse inflammatory pulmonar... |
| TN1131 |
Handelin
|
|
NF-κB
,
Immunology/Inflammation related
|
|
Handelin has anti-inflammatory activity by inhibiting NF-κB activation and pro-inflammatory cytokine productions. |
| TWS1977 |
Kamebakaurin
|
Kamebakaurine |
NF-κB
|
|
1. Kamebakaurin (Kamebakaurine) has the ability to protect the liver from APAP-induced hepatotoxicity, presumably by both inhibiting the inflammatory response and oxidative stress. 2. Kamebakaurin inhibits the expression... |
| T2724 |
Caryophyllene oxide
|
|
Others
,
Endogenous Metabolite
|
|
Caryophyllene oxide is isolated from Aegle marmelos, with anti-inflammatory activity. |
| TN1406 |
Dihydrokaempferol
|
Aromadendrin |
Apoptosis
,
BCL
|
|
Dihydrokaempferol (Aromadendrin) is a natural product. It induces apoptosis and inhibits Bcl-2 and Bcl-xL expression, possesses anti-inflammatory, antioxidant, and anti-diabetic properties, it exhibits anti-inflammatory ... |
| TN1384 |
Angelicain
|
Norcimifugin |
Others
|
|
Angelicain, also known as Norcimifugin, is a component found in Cimicifuga foetida that exhibits anti-inflammatory activity. |
| T5647 |
6-Methylcoumarin
|
Toncarine |
Others
|
|
6-Methylcoumarin (Toncarine) (6MC) is a semisynthetic coumarin with important in vitro and in vivo anti-inflammatory activity. |
| TN5891 |
Seselin
|
|
Antiviral
,
Immunology/Inflammation related
|
|
Seselin is a natural product from Plumbago zeylanica. Seselin shows anti-inflammatory and antiviral activity. |
| TN7021 |
Ent-toddalolactone
|
|
Others
|
|
Ent-toddalolactone is a natural compound belonging to the coumarin group, derived from amphotericin. It has anti-inflammatory and anti-cancer activity. |
| T0269 |
Dichlorisone Acetate
|
Diloderm |
Endogenous Metabolite
,
AChE
|
|
Dichlorisone Acetate (Diloderm) is a synthetic glucocorticoid corticosteroid with anti-inflammatory activity. |
| TN1828 |
Kahweol
|
|
Apoptosis
,
NF-κB
,
AMPK
|
|
Kahweol has anticarcinogenic, anti-angiogenic,and anti-inflammatory activities, it can block the LPS-induced activation of NF-kappaB by preventing IkappaB degradation and inhibiting IkappaB kinase activity. |
| TN7238L |
Sanguinarine citrate
|
Sanguinarium citrate,Sanguinarin citrate,Pseudochelerythrine citrate |
Antibiotic
|
|
Sanguinarine citrate (Pseudochelerythrine chloride) is an alkaloid derived from Sanguinaria Canadensis with antimicrobial, anti-inflammatory, and analgesic activity that is used in the treatment of oral inflammatory dise... |
| T5774 |
Demethylsuberosin
|
7-demethylsuberosin |
Prostaglandin Receptor
|
|
7-Demethylsuberosin (7-demethylsuberosin) is a coumarin compound isolated from Angelica gigas Nakai,and has anti-inflammatory activity,and exhibited inhibitory effects on PGE2 production with the IC50 values of 9.42 μM. |
| TN1257 |
3-O-Acetyl-α-boswellic acid
|
3-O-Acetyl-alpha-boswellic acid,α-Boswellic acid acetate |
Prostaglandin Receptor
|
|
3-O-Acetyl-α-boswellic acid (α-Boswellic acid acetate) has strong anti-inflammatory activity. |
| TN7222 |
2',3',4'-Trimethoxyacetophenone
|
|
|
|
2',3',4'-Trimethoxyacetophenone is a raw material for the preparation of chalcone compounds with anti-inflammatory activity. |
| T5S0662 |
Gelsemine
|
Gelsemin |
Antioxidant
|
|
1. Gelsemine (Gelsemin) has antitumor activity. 2. Gelsemine has anti-oxidative activity. 3. Gelsemine has anti-hyperlipidemic activity. 4. Gelsemine has marked antinociception in inflammatory, neuropathic and bone cance... |
| T3393 |
Triptophenolide
|
Hypolide,(+)-Triptophenolide |
Androgen Receptor
|
|
Triptophenolide (Hypolide) is a compound isolated from Tripterygium wilfordii Hook with anti-inflammatory activity. |
| TN7251 |
Olivetol Dimethyl Ether
|
1,3-dimethoxy-5-pentylbenzene |
Others
|
|
Olivetol Dimethyl Ether is a monoacylglycerol with analgesic activity and potential anti-inflammatory activity that inhibits fatty acid synthesis. |
