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Search Results for " HO-1 "

ターゲット

阻害剤

天然化合物

1735

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T11580	Heme Oxygenase-1-IN-1	HO-1-IN-1	Reactive Oxygen Species
	Heme Oxygenase-1-IN-1 (HO-1-IN-1) is a heme oxygenase 1 (HO-1) inhibitor (IC50: 250 nM).		Reactive Oxygen Species
T11580L	Heme Oxygenase-1-IN-1 hydrochloride	HO-1-IN-1 hydrochloride	Others
	HO-1-IN-1 hydrochloride is a heme oxygenase 1 (HO-1) inhibitor (IC50: 250 nM).		Others
T18006	HO-PEG1-benzyl ester		Others
	HO-PEG1-benzyl ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome sys...		Others
T72827	Nrf2/HO-1-IN-1
	Nrf2/HO-1-IN-1 is a potent Nrf2/HO-1 pathway inhibitor, with an IC 50 value of 0.38 μM for NO . Nrf2/HO-1-IN-1 can significantly reduce the level of ROS in cells. Nrf2/HO-1-IN-1 can be used for researching anti-inflammat...
T61205	Nrf2/HO-1 activator 1
	Nrf2/HO-1 activator 1 (Compound 24) is a potent neuroprotective agent with significant antioxidant activities, specifically targeting Nrf2/HO-1. It is particularly useful in Parkinson's disease (PD) research, illustratin...
T61522	Nrf2/HO-1 activator 2
	Nrf2/HO-1 activator 2 (compound 13m), a difluoro-substituted derivative, is a highly potent activator of Nrf2/HO-1. It exhibits substantial neuroprotective and antioxidant properties by activating the Nrf2/HO-1 pathway t...
T3459	VK3-OCH3	2-[(2-Methoxy)ethylthio]-3-methyl-1,4-na	Others
	VK3-OCH3 (2-[(2-Methoxy)ethylthio]-3-methyl-1,4-na) is a selective antitumor agent via heme oxygenase (HO-1) related mechanisms; Vitamine K3 analogue.		Others
T13396	Zinc Protoporphyrin	Zinc Protoporphyrin-9,ZnPP,Zn(II)-protoporphyrin IX	Apoptosis , Reactive Oxygen Species , Endogenous Metabolite
	Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active and competitive inhibitor of heme oxygenase-1 (HO-1) and markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2, and has anti-can...		Apoptosis , Reactive Oxygen Species , Endogenous Metabolite
T21233	Dihydrolipoic acid	Reduced thioctic acid,Reduced lipoic acid,DHLA,USAF XR-12,6,8-Dihydrothioctic acid	Antioxidant
	Dihydrolipoic acid (USAF XR-12), a dithiol-containing carboxylic acid, acts as a general antioxidant that is highly reactive against a variety of reactive oxygen species, including peroxynitirite, hydroxyl radicals, hydr...		Antioxidant
T18031	Hydroxy-PEG10-acid	HO-PEG10-CH2CH2COOH	Others , PROTAC Linker
	Hydroxy-PEG10-acid (HO-PEG10-CH2CH2COOH) is a PEG-based PROTAC linker that can be used to synthesize PROTACs[1].		Others , PROTAC Linker
T4977	Sofalcone	SU-88	Antibacterial , Autophagy
	Sofalcone (SU-88), a gastric antiulcer agent in clinical use, is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium.		Antibacterial , Autophagy
T36113	Cobaltic Protoporphyrin IX chloride	Protoporphyrin IX cobaltic chloride	Autophagy
	Cobaltic Protoporphyrin IX chloride (CoPP) is a potent heme oxygenase 1 (HO-1) inducer with antiviral activity that inhibits influenza A virus (IAV) infection by inducing a type I IFN response. mTOR inhibitor-8 is a pote...		Autophagy
T13161	Tin-protoporphyrin IX	SnPPIX	Others
	Tin-protoporphyrin IX is a potent inhibitor of Heme oxygenase-1 (HO-1). It sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in mice models.		Others
T74540	Anti-inflammatory agent 38
	Anti-inflammatory agent 38 (compound 23d) is a potent Nrf2/HO-1 pathway inhibitor, with an IC 50 value of 0.38 μM for NO . Nrf2/HO-1-IN-1 can significantly reduce the level of ROS in cells. Nrf2/HO-1-IN-1 can be used for...
T70901	QC-308 HCl
	QC-308 HCl is a novel Heme Oxygenase-1 Inhibitor (HO-1 IC50=0.27μM; HO-2 IC50=0.46μM).
T60847	Heme Oxygenase-2-IN-1
	Heme Oxygenase-2-IN-1 (Compound 9) is a potent, selective inhibitor of heme oxygenase-2 (HO-2). The IC 50 values of Heme Oxygenase-2-IN-1 for HO-1 and HO-2 are 14.9 μM and 0.9 μM, respectively [1].
T17998	HO-PEG-amine (MW 10000)		Others
	HO-PEG-amine (MW 10000) is a polyethylene glycol (PEG) derivative utilized as a PROTAC linker for the synthesis of PROTACs[1].		Others
T61078	Heme Oxygenase-1-IN-2
	Heme Oxygenase-1-IN-2 is a novel inhibitor of heme oxygenase-1 (HO-1), displaying potent antiproliferative activity in vitro, with an IC50 value of 0.95 μM.
T41175	OB 24 hydrochloride
	OB 24 hydrochloride is a potent and selective heme oxygenase 1 (HO-1) inhibitor (IC50 values are 1.9 and >100 μM for HO-1 and HO-2 respectively), reduces protein carbonylation and reactive oxygen species formation in adv...
T68288	OB-24 free base
	OB-24 free base is a potent and selective heme oxygenase 1 (HO-1) inhibitor.
T18002	HO-PEG-CH2COOH (MW 3400)		Others
	HO-PEG-CH2COOH (MW 3400) is a PEGylated PROTAC linker with a molecular weight of 3400. It serves as a PEG-based building block for the synthesis of PROTACs[1].		Others
T15494	HO-PEG8-CH2CH2COOH	Hydroxy-PEG8-acid	Others
	Hydroxy-PEG8-acid (HO-PEG8-CH2CH2COOH) is a PEG-based PROTAC linker employed for PROTAC synthesis[1].		Others
T26596	Allylpyrocatechol
	Allylpyrocatechol is an antioxidant. Allylpyrocatechol attenuates collagen-induced arthritis via attenuation of oxidative stress secondary to modulation of the MAPK, JAK/STAT, and Nrf2/HO-1 pathways.
T18003	HO-PEG-CH2COOH (MW 5000)		Others
	HO-PEG-CH2COOH (MW 5000), a polyethylene glycol (PEG)-based PROTAC linker, serves as a valuable component in the synthesis of PROTACs[1].		Others
T79507	Anti-inflammatory agent 48		NF-κB
	Anti-inflammatory agent 48 functions by inhibiting the NF-κB signaling pathway and activating HO-1 expression, characterizing its role as an anti-inflammatory agent [1].		NF-κB
T78623	Cobalt protoporphyrin IX		Reactive Oxygen Species
	Cobalt Protoporphyrin IX serves as a potent, specific inducer of heme oxygenase-1 (HO-1) and demonstrates broad-spectrum antiviral effects against Influenza A virus (IAV) [1].		Reactive Oxygen Species
T34811	Terrein	NSC 291308,Terrain,(+)Terrein,NSC291308,NSC-291308
	Terrain, also known as NSC 291308, is a fungal metabolite with diverse biological activities. Terrein reduces age-related inflammation induced by oxidative stress through Nrf2/ERK1/2/HO-1 signalling in aged HDF cells. (+...
T127402	Coenzyme Q0	CoQ0
	Coenzyme Q0 (CoQ0), a potent, orally active ubiquinone compound derived from Antrodia cinnamomea, induces apoptosis and autophagy. It suppresses HER-2/AKT/mTOR signaling, enhancing apoptosis and autophagy mechanisms. Add...
T62111	Antioxidant agent-5
	Antioxidant agent-5 (compound D-6) is a potent antioxidant. antioxidant agent-5 inhibits oxLDL-induced increases in ROS levels and NF-κB nuclear translocation. antioxidant agent-5 inhibits oxLDL (oxidized LDL)-induced ap...
T75238	YS-49 monohydrate
	YS-49 (monohydrate) is an isoquinoline compound alkaloid that functions as a PI3K/Akt activator, specifically targeting a downstream effect of RhoA, to mitigate the activation of RhoA/PTEN in 3-methylcholanthrene-treated...

Compounds

Heme Oxygenase-1-IN-1

T11580

Synonym: HO-1-IN-1

Target: Reactive Oxygen Species

Heme Oxygenase-1-IN-1 hydrochloride

T11580L

Synonym: HO-1-IN-1 hydrochloride

Nrf2/HO-1 activator 1

T61205

Synonym:

Target:

Nrf2/HO-1 activator 2

Synonym: 2-[(2-Methoxy)ethylthio]-3-methyl-1,4-na

Target: Others

Zinc Protoporphyrin

T13396

Synonym: Zinc Protoporphyrin-9,ZnPP,Zn(II)-protoporphyrin IX

Target: Apoptosis, Reactive Oxygen Species, Endogenous Metabolite

Dihydrolipoic acid

T21233

Synonym: Reduced thioctic acid,Reduced lipoic acid,DHLA,USAF XR-12,6,8-Dihydrothioctic acid

Target: Antioxidant

Hydroxy-PEG10-acid

T18031

Synonym: HO-PEG10-CH2CH2COOH

Target: Others, PROTAC Linker

Sofalcone

T4977

Synonym: SU-88

Target: Antibacterial, Autophagy

Cobaltic Protoporphyrin IX chloride

T36113

Synonym: Protoporphyrin IX cobaltic chloride

Target: Autophagy

Tin-protoporphyrin IX

T13161

Synonym: SnPPIX

Target: Others

Anti-inflammatory agent 38

Heme Oxygenase-2-IN-1

T60847

Synonym:

Target:

HO-PEG-amine (MW 10000)

T17998

Synonym:

Target: Others

Heme Oxygenase-1-IN-2

HO-PEG-CH2COOH (MW 3400)

Synonym: Hydroxy-PEG8-acid

HO-PEG-CH2COOH (MW 5000)

T18003

Synonym:

Target: Others

Anti-inflammatory agent 48

T79507

Synonym:

Target: NF-κB

Cobalt protoporphyrin IX

T78623

Synonym:

Target: Reactive Oxygen Species

Terrein

T34811

Synonym: NSC 291308,Terrain,(+)Terrein,NSC291308,NSC-291308

カタログ番号	製品名	別名	ターゲット
TN3609	Catalposide	Hydroxybenzoyl catalpol	ERK , IL Receptor , TNF , NOS , NF-κB , NO Synthase , PPAR , Autophagy
	Catalposide is a potent inducer of (HO)-1 isolated from Catalpa ovate G. Don (Bignoniaceae). Catalposide possesses antioxidant, anti-apoptotic, anti-microbial, anti-tumoral, and anti-inflammatory properties.
TN3694	Coniferaldehyde		NOS , COX , Nrf2 , PKC , Autophagy
	Coniferaldehyde can significantly inhibit the growth of viability of strains of Oenococcus oeni. Coniferaldehyde exerts anti-inflammatory properties by inducing heme oxygenase-1(HO-1).		NOS , COX , Nrf2 , PKC , Autophagy
TN4661	Nodosin		IL Receptor , Autophagy
	Nodosin has anti-inflammatory function of Nodosin via inhibition of IL-2. Nodosin perfusion provides a potential protective effect through inducing HO-1 expression to attenuate ischemia/reperfusion injury in liver transp...		IL Receptor , Autophagy
T5515	Hemin	Hemin chloride	Mitophagy , Ferroptosis , Autophagy
	Hemin (Hemin chloride) is a chlorinated iron-containing porphyrin, a heme oxygenase (HO)-1 inducer. Hemin has therapeutic activity in porphyrias by reducing heme deficiency in patients, thereby inhibiting δ-aminolevulini...		Mitophagy , Ferroptosis , Autophagy
TN6694	5,6-Benzoflavone	β-Naphthoflavone,beta-NF	Antioxidant
	5,6-Benzoflavone (β-Naphthoflavone) is an exogenous ligand for the aryl hydrocarbon receptor, which disrupts zinc homeostasis in human hepatocellular carcinoma HepG2 cells. 5,6-Benzoflavone (β-Naphthoflavone) possesses a...		Antioxidant
T3385	Gypenoside XVII	GP-17,Gynosaponin S	Estrogen Receptor/ERR , GSK-3 , Endogenous Metabolite
	Gypenoside XVII (Gynosaponin S) confers protection against Aβ25-35-induced neurotoxicity through estrogen receptor-dependent activation of PI3K/Akt pathways, activation of Nrf2/ARE/HO-1 and inactivation of GSK-3β pathway...		Estrogen Receptor/ERR , GSK-3 , Endogenous Metabolite
TN1677	Gartanin		BCL , Caspase , JNK
	Gartanin is an androgen receptor degradation enhancer, it is also a potential neuroprotective agent against glutamate-induced oxidative injury partially through increasing Nrf-2-independed HO-1 and AMPK/SIRT1/PGC-1α±sign...		BCL , Caspase , JNK
T3410	Momordin Ic	Momordin 1c	Apoptosis , MAPK , PI3K
	Momordin Ic (Momordin 1c) might represent a potential anticancer activity, by inducing apoptosis through oxidative stress-regulated mitochondrial dysfunction involving the MAPK and PI3K-mediated iNOS and HO-1 pathways. A...		Apoptosis , MAPK , PI3K
T2909	Fraxetin	7,8-dihydroxy-6-methoxy coumarin	Apoptosis , Others
	Fraxetin (7,8-dihydroxy-6-methoxy coumarin) has dual-antioxidative ,hepatoprotective and antihyperglycemic functions, it shows potent protective effects against CCl4 induced oxidative stress and hepatic fibrosis, has a m...		Apoptosis , Others
TN2244	Sulfuretin		NF-κB , Autophagy
	Sulfuretin is a potent anti-oxidant, has protective effect against t-BHP-induced oxidative damage in human liver-derived HepG2 cells is attributable to its ability to scavenge ROS and up-regulate the activity of HO-1 thr...		NF-κB , Autophagy
TN5171	Tricetin		Apoptosis , Others , Nrf2
	Tricetin is a flavonoid isolated from pomegranate.Tricetin is a potent competitive inhibitor of Keap1-Nrf2 protein-protein interaction (PPI) and protects Parkinson's disease patients from 6-OHDA-induced neurotoxicity by ...		Apoptosis , Others , Nrf2
T6S0525	Farrerol		ERK , p38 MAPK , Akt
	1. Farrerol has antioxidative activity.2. Farrerol modulates TAP and BNBD5 gene expression in mammary gland, enhances bMEC defense against S. aureus infection and could be useful in protection against bovine mastitis. 3....		ERK , p38 MAPK , Akt
T5S1805	5,7-Dihydroxychromone	5,7-Dihydroxy-4H-Chromen-4-One	Others , Virus Protease , PARP , Caspase , Nrf2
	1. 5,7-Dihydroxychromone (5,7-Dihydroxy-4H-Chromen-4-One) isolated from DME is one of the active compounds that may contribute to regulate blood glucose levels. 2. 5,7-Dihydroxychromone exerts neuroprotective effect agai...		Others , Virus Protease , PARP , Caspase , Nrf2
T6429	Caffeic Acid Phenethyl Ester	Phenylethyl Caffeate,CAPE	Apoptosis , NF-κB
	Caffeic Acid Phenethyl Ester (Phenylethyl Caffeate) (CAPE) inhibits the activation of nuclear transcription factor NF-kappa B and may suppress p70S6K and Akt-driven signaling pathways, with antineoplastic, cytoprotective...		Apoptosis , NF-κB
T0973L	Pyridoxine hydrochloride	Pyridoxine HCl,Pyridoxol (hydrochloride),Vitamin B6 (hydrochloride),Vitamin B6	Nrf2 , Endogenous Metabolite
	Pyridoxine hydrochloride (Vitamin B6) is the 4-methanol form of vitaminB6 which is converted to pyridoxal phosphate which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingo...		Nrf2 , Endogenous Metabolite
T3673	Mollugin	Rubimaillin	HER , JAK
	Mollugin (Rubimaillin) may be a JAK2 inhibitor and inhibits LPS-induced inflammatory responses by blocking the activation of the JAK-STAT pathway. Mollugin as a candidate for a chemotherapeutic agent in OSCCs via the upr...		HER , JAK
T7472	7-Hydroxyflavone		P450
	7-Hydroxyflavone is a potent inhibitor of CYP1A1 with a Ki value of 0.015 μM and exhibits 6-fold greater selectivity for CYP1A1 over CYP1A2.with anti-inflammatory activity		P450
T6S1572	Sauchinone		ERK , p38 MAPK , NF-κB
	1. Sauchinone is a useful adjunctive treatment for bacterial infection. 2. Sauchinone, an active lignan found in Saururus chinensis, to regulate the activation of HSCs, to prevent liver fibrosis, and to inhibit oxidative...		ERK , p38 MAPK , NF-κB
T6S2099	Geraniin		Antioxidant , TNF
	1. Geraniin has a protective effect against OVX-induced rat osteoporosis. 2. Geraniin has cytotoxic activity towards cancer cells in vitro and in vivo. 3. Geraniin exerts inhibitory effects on osteoclast differentiation ...		Antioxidant , TNF
TN1674	Garcinone D		Reactive Oxygen Species , Nrf2 , STAT
	Garcinone D shows significant cytotoxicity against the CEM-SS cell line, with IC(50) value of 3.2 microg/ml; it exhibits dose-dependent enzyme-based microsomal aromatase inhibitory activity. Garcinone D inhibits p65 acti...		Reactive Oxygen Species , Nrf2 , STAT
T0973	Pyridoxine	Pyridoxol,Vitamin B6,Gravidox	PLK , Nrf2 , Endogenous Metabolite
	Pyridoxine (Vitamin B6) is the 4-methanol form of vitamin B6 and is converted to pyridoxal 5-phosphate in the body. Although pyridoxine and vitamin B6 are still frequently used as synonyms, especially by medical research...		PLK , Nrf2 , Endogenous Metabolite
T2S1907	Coniferaldehyde	Ferulaldehyde,Ferulyl aldehyde,4-HYDROXY-3-METHOXYCINNAMALDEHYDE,Coniferyl aldehyde	Apoptosis , Antioxidant
	Coniferaldehyde (Ferulaldehyde) is a member of the class of cinnamaldehydes that is cinnamaldehyde substituted by a hydroxy group at position 4 and a methoxy group at position 3. It has a role as an antifungal agent and ...		Apoptosis , Antioxidant
T6S2227	Spinosin	Flavoayamenin	Others
	1. Spinosin (Flavoayamenin) ameliorated memory impairment induced through AβO, the serotonergic neurotransmitter system, and these effects were regulated, in part, through neuroprotective activity via the anti-inflammato...		Others
TN1245	3-Deoxysappanchalcone		Others , Akt , mTOR
	3-Deoxysappanchalcone is an effective HO-1 inducer at the translational level.		Others , Akt , mTOR
T11365	Ganodermanontriol		Others
	Ganodermanontriol, a sterol derived from Ganoderma lucidum, showcases hepatoprotective activity and possesses anti-inflammatory properties in tert-butyl hydroperoxide (t-BHP)-damaged hepatic cells through the upregulatio...		Others
TN3057	4-O-Methylbutein		Autophagy
	4-O-Methylbutein (2',3,4'-trihydroxy-4-methoxychalcone) may have anti-inflammation activity, it is a potent heme oxygenase-1 (HO-1) inducer, the upregulation of HO-1 has proven to be a useful tool for fighting inflammati...		Autophagy
T3490	Alpha-(3,4-Dihydroxyphenyl)lactic acid		Antioxidant
	Danshensu has antioxidant activity, can enhance HO-1 expression to suppress 6-OHDA-induced oxidative damage via PI3K/Akt/Nrf2 signaling pathways.		Antioxidant
TN6422	Ethyl (E)-ferulate
	Ethyl ferulate could be used for therapeutic purposes as a potent inducer of HO-1 for the protection of brain cells against oxidative and neurodegenerative conditions.
T73681	Aspidin BB
	Aspidin BB, a phloroglucinol derivative isolated from the aerial part of Dryopteris championii, exhibits anticancer activity. It induces cell cycle arrest and apoptosis in human ovarian HO-8910 cells [1] [2].
T79930	Sanggenon A	Sanggenone A	NF-κB
	Sanggenon A (Sanggenone A) exhibits anti-inflammatory properties by modulating the NF-κB and HO-1/Nrf2 signaling pathways in BV2 and RAW264.7 cells, and it significantly suppresses Lipopolysaccharide (LPS)-induced nitric...		NF-κB
TMA0984	Cerevisterol		DNA/RNA Synthesis
	Cerevisterol is a cytotoxic steroid, can inhibit the activity of DNA polymerase alpha. It can stimulate NGF-mediated neurite outgrowth on PC12 cells.		DNA/RNA Synthesis
TMA1012	Ganoderiol F		Androgen Receptor , HIV Protease , Autophagy
	Ganoderiol F has anti-inflammatory, cytotoxic and anti-HIV activity, it inhibits activity of topoisomerases in vitro, and it inhibits human immunodeficiency virus-1 protease with IC(50) values of 20-40 microM. It induced...		Androgen Receptor , HIV Protease , Autophagy
T4S0083	Protostemonine		Others
	1. Protostemonine has anti-inflammatory activity, it effectively attenuates LPS-induced inflammatory responses in vitro and in vivo; the beneficial effects are associated with the decreased phosphorylation of MAPK and AK...		Others
TN3806	Dehydroglyasperin C		ERK , IκB/IKK , p38 MAPK , TNF , NF-κB , Akt , COX , PI3K , NADPH , DNA/RNA Synthesis , Nrf2 , JNK , Autophagy
	Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemopreventive, and neuroprotective activities, it has protectiv...
TN4778	Physalin H		gp120/CD4 , Antifection , Autophagy
	Physalin H is an Hh signaling inhibitor blocks GLI1-DNA-complex formation, it also strong quinone reductase induction activity with IR (Induction ratio, QR induction activity) value of 3.74±0.02. Physalin H shows immunos...		gp120/CD4 , Antifection , Autophagy

天然物製品

Catalposide

TN3609

Synonym: Hydroxybenzoyl catalpol

Target: ERK, IL Receptor, TNF, NOS, NF-κB, NO Synthase, PPAR, Autophagy

Coniferaldehyde

TN3694

Synonym:

Target: NOS, COX, Nrf2, PKC, Autophagy

Nodosin

TN4661

Synonym:

Target: IL Receptor, Autophagy

Hemin

T5515

Synonym: Hemin chloride

Target: Mitophagy, Ferroptosis, Autophagy

5,6-Benzoflavone

TN6694

Synonym: β-Naphthoflavone,beta-NF

Target: Antioxidant

Gypenoside XVII

T3385

Synonym: GP-17,Gynosaponin S

Target: Estrogen Receptor/ERR, GSK-3, Endogenous Metabolite

Gartanin

TN1677

Synonym:

Target: BCL, Caspase, JNK

Momordin Ic

T3410

Synonym: Momordin 1c

Target: Apoptosis, MAPK, PI3K

Fraxetin

T2909

Synonym: 7,8-dihydroxy-6-methoxy coumarin

Target: Apoptosis, Others

Sulfuretin

TN2244

Synonym:

Target: NF-κB, Autophagy

Tricetin

TN5171

Synonym:

Target: Apoptosis, Others, Nrf2

Farrerol

T6S0525

Synonym:

Target: ERK, p38 MAPK, Akt

5,7-Dihydroxychromone

T5S1805

Synonym: 5,7-Dihydroxy-4H-Chromen-4-One

Target: Others, Virus Protease, PARP, Caspase, Nrf2

Caffeic Acid Phenethyl Ester

T6429

Synonym: Phenylethyl Caffeate,CAPE

Target: Apoptosis, NF-κB

Pyridoxine hydrochloride

T0973L

Synonym: Pyridoxine HCl,Pyridoxol (hydrochloride),Vitamin B6 (hydrochloride),Vitamin B6

Target: Nrf2, Endogenous Metabolite

Target: ERK, p38 MAPK, NF-κB

Geraniin

T6S2099

Synonym:

Target: Antioxidant, TNF

Garcinone D

TN1674

Synonym:

Target: Reactive Oxygen Species, Nrf2, STAT

Pyridoxine

T0973

Synonym: Pyridoxol,Vitamin B6,Gravidox

Target: PLK, Nrf2, Endogenous Metabolite

Coniferaldehyde

T2S1907

Synonym: Ferulaldehyde,Ferulyl aldehyde,4-HYDROXY-3-METHOXYCINNAMALDEHYDE,Coniferyl aldehyde

Target: Apoptosis, Antioxidant

Spinosin

T6S2227

Synonym: Flavoayamenin

Target: Others

3-Deoxysappanchalcone

TN1245

Synonym:

Target: Others, Akt, mTOR

alpha-(3,4-Dihydroxyphenyl)lactic acid

Synonym: Sanggenone A

Target: DNA/RNA Synthesis

Ganoderiol F

TMA1012

Synonym:

Target: Androgen Receptor, HIV Protease, Autophagy

Target: ERK, IκB/IKK, p38 MAPK, TNF, NF-κB, Akt, COX, PI3K, NADPH, DNA/RNA Synthesis, Nrf2, JNK, Autophagy

Physalin H

TN4778

Synonym:

Target: gp120/CD4, Antifection, Autophagy

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPJ-00817	HO-1 Protein, Human, Recombinant	Human	E. coli
	Heme Oxygenase 1 (HO-1) is an enzyme in endoplasmic reticulum that belongs to the heme oxygenase family. HO-1 cleaves the heme ring at the alpha methene bridge to form Biliverdin. Biliverdin is subsequently converted to ...
TMPY-02519	BLVRB Protein, Human, Recombinant (His)	Human	E. coli
	Biliverdin reductase (hBVR) is a serine/threonine kinase that catalyzes reduction of the heme oxygenase (HO) activity product, biliverdin, to bilirubin. BVR consists of an N-terminal dinucleotide-binding domain (Rossmann...
TMPY-04451	AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST) is expressed in Baculovirus-Insect Cells
TMPY-03878	Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His)	Human	HEK293
	Integrin alpha-5, also known as ITGA5, is a single-pass type I membrane protein which belongs to the integrin alpha chain family. ITGA5 contains 7 FG-GAP repeats. Alpha chain 5 undergoes post-translational cleavage in th...
TMPY-02501	CD3D & CD3E Heterodimer Protein, Human, Recombinant	Human	HEK293
	CD3D & CD3E Heterodimer Protein, Human, Recombinant is expressed in HEK293 cells.
TMPY-03745	CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His)	Human	HEK293
	CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His) is expressed in HEK293 with Flag and His tag. The predicted molecular weight is 31.05 kDa. Accession number: P04234-1&P07766-1
TMPY-02794	TLR2 Protein, Human, Recombinant (aa 1-587, His)	Human	Baculovirus-Insect Cells
	TLR2, also known as CD282, is a member of the Toll-like receptor (TLR) family. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They play a fundamental role in pathoge...
TMPY-03947	CD48 Protein, Human, Recombinant (hFc)	Human	HEK293
	Cluster of Differentiation 48 (CD48), also known as SLAMF2, BCM-1 and BLAST-1, is a GPI-linked protein belonging to the CD2 subfamily of immunoglobulin superfamily molecules. CD2 and 2B4 (CD244) are known ligands for CD4...
TMPY-03481	IL-1R2 Protein, Human, Recombinant	Human	HEK293
	Interleukin 1 receptor, type II (IL1R2) also known as CD121b (Cluster of Differentiation 121b) is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein binds interleukin alpha (IL1A), interl...
TMPY-04384	Src Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	Proto-oncogene tyrosine-protein kinase SRC is a hydrophobic protein belonging to the SRC family kinase including nine members that is a family of non-receptor tyrosine kinases. SRC protein may exist in different forms: C...
TMPK-00114	C-Reactive Protein /CRP Protein, Human, Recombinant (His)	Human	HEK293
	C-reactive protein (CRP) is a polypeptide molecule belonging to the family of pentraxins. CRP is synthesized primarily by the liver in response to certain pro-inflammatory cytokines. It plays an important role in innate ...
TMPK-00383	ACE2/ACEH Protein, Human, Recombinant (His & Avi)	Human	HEK293
	ACE2 (Angiotensin I Converting Enzyme 2) is a Protein Coding gene. Diseases associated with ACE2 include Severe Acute Respiratory Syndrome and Neurogenic Hypertension.The protein encoded by this gene belongs to the angio...
TMPY-02525	RGMA Protein, Human, Recombinant (His)	Human	HEK293
	RGMa, also known as RGM domain family, member A, belongs to the RGM (repulsive guidance molecule) family whose members are membrane-associated glycoprotein. RGMa is a glycosylphosphatidylinositol-anchored glycoprotein th...
TMPY-04413	IRE1 Protein, Human, Recombinant (aa 465-977, His & GST)	Human	Baculovirus-Insect Cells
	Endoplasmic reticulum stress and hypoxia are necessary components of malignant tumors growth and suppression of ERN1 (from endoplasmic reticulum to nuclei-1) signalling pathway, which is linked to the apoptosis and cell ...
TMPY-04753	IRE1 Protein, Human, Recombinant (aa 465-977)	Human	Baculovirus-Insect Cells
	Endoplasmic reticulum stress and hypoxia are necessary components of malignant tumors growth and suppression of ERN1 (from endoplasmic reticulum to nuclei-1) signalling pathway, which is linked to the apoptosis and cell ...
TMPK-01393	Tenascin Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Tenascin-C (TNC) is a hexameric, multimodular extracellular matrix protein with several molecular forms that are created through alternative splicing and protein modifications. It is highly conserved amongst vertebrates,...
TMPY-00740	SDF-1 Protein, Human, Recombinant (hFc)	Human	HEK293
	The human stromal cell-derived factor-1 (SDF1), also known as CXCL12, is a small (8 kDa) cytokine highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. SDF1 is expressed in two isoforms f...
TMPK-01074	CD163 Protein, Human, Recombinant (His & Avi)	Human	HEK293
	The hemoglobin (Hb) scavenger receptor, CD163, is a macrophage-specific protein and the upregulated expression of this receptor is one of the major changes in the macrophage switch to alternative activated phenotypes in ...
TMPK-01151	MXRA8 Protein, Human, Recombinant (His)	Human	HEK293
	Mxra8 is a recently described receptor for multiple alphaviruses, including Chikungunya (CHIKV), Mayaro (MAYV), Ross River (RRV), and O'nyong nyong (ONNV) viruses.
TMPK-00305	TGFBR1 Protein, Human, Recombinant (mFc & Avi)	Human	HEK293
	transforming growth factor beta receptor 1 (TGFBR1), a key stimulator of tumor proliferation and metastasis, was a direct target of miR‑98‑5p. miR‑98‑5p overexpression resulted in the downregulation of TGFBR1 and the sup...
TMPY-01460	ABHD4 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	Abhydrolase domain containing 4 (ABHD4), also known as alpha/beta-hydrolase 4 (ABH4) , or lyso-N-acylphosphatidylethanolamine lipase, which belongs to the ABHD4/ABHD5 subfamily of peptidase S33 family. Abhydrolase domain...
TMPY-00978	Progranulin Protein, Human, Recombinant (His)	Human	HEK293
	Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The precursor protein, progranulin, ...
TMPY-01065	GM-CSFR alpha Protein, Human, Recombinant (His)	Human	HEK293
	CD116/GM-CSFR has been preferentially associated with M4, M5 subtype of AML but is not specific. The cluster of differentiation (cluster of designation) (often abbreviated as CD) is a protocol used for the identification...
TMPY-04966	PCSK9 Protein, Human, Recombinant (D374Y, His)	Human	HEK293
	Proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as NARC1 (neural apoptosis regulated convertase), which is a newly identified human secretory subtilase belonging to the proteinase K subfamily of the sec...
TMPY-03630	MZB1/PERP1 Protein, Human, Recombinant (His)	Human	HEK293
	MZB1 (Marginal Zone B And B1 Cell Specific Protein, also known as MEDA-7 and pERp1) is a Protein Coding gene. MZB1 is a B-cell-specific and endoplasmic reticulum (ER)-localized protein implicated in antibody secretion an...
TMPY-02327	HGF Protein, Human, Recombinant	Human	CHO
	Hepatocyte growth factor, also known as HGF, contains 4 kringle domains, 1 PAN domain, and 1 peptidase S1 domain. It belongs to the peptidase S1 family, plasminogen subfamily. The hepatocyte growth factor is secreted by ...
TMPY-01936	VEGFR3/FLT4 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Vascular endothelial growth factor receptor 3 (VEGFR3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belo...
TMPY-01085	VLDLR Protein, Human, Recombinant (His)	Human	HEK293
	The very low density lipoprotein receptor, known as VLDLR, is a single-pass type 1 integral membrance protein and a member of the LDL receptor family. This receptor family includes LDL receptor, LRP, megalin, VLDLR and A...
TMPY-02647	IFNAR1 Protein, Human, Recombinant (His)	Human	HEK293
	Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus prote...
TMPY-01907	VSIG4 Protein, Human, Recombinant (His)	Human	HEK293
	VSIG4 (V-set and immunoglobulin domain containing 4), also known as complement receptor of the immunoglobulin superfamily (CRIg) and Z39Ig, is a type I transmembrane glycoprotein. It is a B7 family-related protein and an...
TMPY-00972	FGFR2 Protein, Human, Recombinant (His & hFc)	Human	HEK293
	FGFR2, also known as CD332, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR2 acts as cell-surface receptor for fibro...
TMPY-00947	VCAM-1 Protein, Human, Recombinant (hFc)	Human	HEK293
	Vascular cell adhesion molecule 1 (VCAM-1), also known as CD106, is a cell surface sialoglycoprotein belonging to the immunoglobulin superfamily. Two forms of VCAM-1 with either six or seven extracellular Ig-like domains...
TMPY-01776	Carboxylesterase 2/CES2 Protein, Human, Recombinant (His)	Human	HEK293
	Carboxylesterase 2 (CES2) is a member of the carboxylesterase family and belongs to the multigene family. Carboxylesterase 2 is responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and...
TMPY-03363	C-Reactive Protein Protein, Human, Recombinant	Human	HEK293
	C-reactive protein (CRP) is synthesized by the liver in response to factors released by fat cells. It is a member of the pentraxin family of proteins. The levels of CRP rise in response to inflammation. Human C-reacti...
TMPY-04262	B7-H3 Protein, Human, Recombinant (His), Biotinylated	Human	HEK293
	B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an important role in adaptive immune responses, and was shown to ei...
TMPY-04925	CD8 beta Protein, Human, Recombinant, Biotinylated	Human	HEK293
	CD8B (CD8b molecule), also known as P37 and LEU2, contains 1 Ig-like V-type (immunoglobulin-like) domain. The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-...
TMPY-02575	PPAR gamma/PPARG Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	Peroxisome proliferator-activated receptor gamma (PPARG), a nuclear hormone receptor, plays a critical role in the lipid and glucose homeostasis, adipocyte differentiation, as well as intracellular insulin-signaling even...
TMPY-01166	TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His)	Human	HEK293
	Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B), also known as Tumor necrosis factor receptor 2 (TNFR2) or CD120b antigen, is a member of the tumor necrosis factor receptor superfamily. TNFR2/CD120b/TNFR...
TMPY-02836	MFGE8 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	MFG-E8, also known as lactadherin and MFGE8, contains 1 EGF-like domain and 2 F5/8 type C domains. It also contains phosphatidylserine (PS) binding domain, as well as an Arginine-Glycine-Aspartic acid motif, which enable...
TMPY-05493	LIFR Protein, Human, Recombinant (hFc)	Human	HEK293
	LIFR (leukemia inhibitory factor receptor) belongs to the family of cytokine receptors. LIFR forms a high-affinity receptor complex with gp130, which mediates the activity of LIF (leukemia inhibitory factor) and thus aff...
TMPY-01037	CSF1R Protein (Met1-Glu512), Human, Recombinant (His)	Human	HEK293
	M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1 (CSF1R), a cytokine involved in the proliferation, differentiation, and activation of macrophages. This cell surface glycoprotein...
TMPY-01461	EMAP-II/AIMP1 Protein, Human, Recombinant (His)	Human	E. coli
	Aminoacyl tRNA synthase complex-interacting multifunctional protein 1, also known as Multisynthase complex auxiliary component p43, Endothelial monocyte-activating polypeptide II, AIMP1, EMAP2 and SCYE1, is a nucleus pro...
TMPY-00772	DC-SIGN Protein, Human, Recombinant (hFc)	Human	HEK293
	Dendritic cell (DC)-specific intercellular adhesion molecule 3 (ICAM-3) grabbing nonintegrin (DC-SIGN), also known as CD209, is a type II transmembrane protein on DCs with a C-type lectin extracellular domain, is capable...
TMPY-03407	NQO1 Protein, Human, Recombinant (His)	Human	E. coli
	NQO1 gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. NQO1 forms homodimers and reduces quinones to hydroquinones. NQO1's enzymatic activity prevents the one-...
TMPY-00915	Serpin A1 Protein, Human, Recombinant (His)	Human	HEK293
	SerpinA1, also known as Alpha-1 antitrypsin (AAT), is a prototype member of the Serpin superfamily of the serine protease inhibitors. This serine protease inhibitor blocks the protease, neutrophil elastase. Alpha-1 antit...
TMPY-00654	ACVR2B Protein, Human, Recombinant (hFc)	Human	HEK293
	ACVR2A and ACVR2B are two activin type II receptors. ACVR2B is integral to the activin and myostatin signaling pathway. Ligands such as activin and myostatin bind to ACVR2A and ACVR2B. Myostatin, a negative regulator of ...
TMPY-00203	LOXL2 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Lysyl oxidase homolog 2, also known as Lysyl oxidase-like protein 2, Lysyl oxidase-related protein 2, Lysyl oxidase-related protein WS9-14 and LOXL2, is a secreted protein that belongs to the lysyl oxidase family. LOXL2 ...
TMPY-02813	ErbB4 Protein, Human, Rhesus, Recombinant (His)	Human,Rhesus	HEK293
	ERBB4 is a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. ERBB4 is ...
TMPY-01104	Coagulation factor XI/F11 Protein, Human, Recombinant (His)	Human	HEK293
	Factor XI (plasma thromboplastin antecedent) is a plasma glycoprotein, and a zymogen acting as a serine protease which participates in blood coagulation as a catalyst in the conversion of factor IX to factor IXa in the p...
TMPY-01829	CD83 Protein, Human, Recombinant (His)	Human	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
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