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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T9782 | Cytochrome C | Others | |
Cytochrome C, a protein that belongs to class 1 of the c-type cytochrome family, exerts different functions depending on its cellular localization and the conditions in which it operates. | |||
T21688L | Cytochrome c - pigeon (88-104) Acetate | Cytochrome c - pigeon (88-104) Acetate (86579-06-8 Free base) | Others |
Cytochrome c - pigeon (88-104) Acetate (Cytochrome c - pigeon ) is specific for a peptide within the COOH-terminal sequence 88-1041. | |||
T25283 | Cytochrome P450 2C9 | Cyp2C9,Human cytochrome P450 2C9,Cytochrome P 450 2C9,S-Mephenytoin 4-hydroxylase | |
Cytochrome P450 2C9 is a cytochrome P-450 subtype that possesses specificity for acidic xenobiotics. It oxidizes a wide range of important clinical drugs under the categories of nonsteroidal anti-inflammatory agents, ant... | |||
TP1855 | Moth Cytochrome C (MCC) (88-103) | Moth Cytochrome C (MCC) 88-103 | |
Moth Cytochrome C (MCC) (88-103), derived from the carboxyl terminus of moth cytochrome c, induces positive selection of TCR transgenic thymocytes.This peptide is derived from the carboxyl terminus of moth cytochrome c. ... | |||
TP2237 | Cytochrome c fragment (93-108) | Others | |
Cytochrome c fragment (93-108) is a peptide from Cytochrome c, which is a small heme protein found loosely associated with the inner membrane of the mitochondrion. Cytochromes c from certain eukaryotes, including plants ... | |||
TP2238 | Cytochrome P450 CYP1B1 (190-198) [Homo sapiens] | Others | |
Cytochrome P450 CYP1B1 (190-198) [Homo sapiens] is a peptide from Cytochrome c, which is a small heme protein found loosely associated with the inner membrane of the mitochondrion. Cytochromes c from certain eukaryotes, ... | |||
T80057 | Cytochrome P450 reductase | ||
Cytochrome P450 reductase, a NADPH-cytochrome reductase, facilitates an optimal conformation of aromatase for substrate binding [1]. | |||
T27617 | Inz-1 | P450 | |
Inz-1 is an effective and fungal-selective inhibitor of mitochondrial cytochrome bc1 with IC50s of 8.092 and 45.320 μM for yeast and human. Inz-1 reverses Fluconazole or other triazole antifungals’ resistance in the path... | |||
T17022 | Tebuconazole | P450 , Antifungal | |
Tebuconazole is an agricultural azole fungicide. It can also inhibit CYP51 (IC50s: 0.9 and 1.3 μM for Candida albicans CYP51 and truncated Homo sapiens CYP51, respectively). | |||
T10953 | Dafadine-A | P450 | |
Dafadine-A is an analog of dafadine and a novel inhibitor of DAF-9 cytochrome P450 in the nematode Caenorhabditis elegans. Mammalian orthologs that also inhibit DAF-9 (CYP27A1). | |||
T7427 | 1-Ethynylnaphthalene | P450 | |
1-Ethynylnaphthalene is a selective inhibitor of cytochrome P450 IB1 | |||
T21482 | Uniconazole | P450 , ROS Kinase | |
Uniconazole is a plant growth regulator that inhibit cytochrome P450 707As (Ki=68 nM). CYP707As is a major ABA catabolic enzyme that catabolize Abscisic acid, accordingly suppress gibberellin and sterol biosynthesis. | |||
T21529 | (S)-Mephenytoin | Others | |
(S)-Mephenytoin ((+)-Mephenytoin) anticonvulsant effect. It is a substrate of the cytochrome P450 (CYP) isoform CYP2C19 and can be used to analyze cytochrome P450 metabolism. | |||
T9704 | 1-Ethynylpyrene | P450 | |
1-Ethynylpyrene is an aryl acetylenic inhibitor of CYTP450 1A1(IC50=0.18 μM), 1A2(IC50 = 0.32 μM), and 2B1(IC50 = 0.04 μM). | |||
T4190 | Ticlopidine | PCR 5332,Ticlid | ATPase , Adiponectin receptor |
Ticlopidine (PCR 5332) is an antiplatelet drug in the thienopyridine family which is an adenosine diphosphate (ADP) receptor inhibitor. | |||
T7410 | Furafylline | P450 | |
Furafylline is a selective inhibitor of human cytochrome P450 (CYP)1A2 (IC50 : 0.07 µM), | |||
T11991 | Mefentrifluconazole | P450 , Antifungal | |
Mefentrifluconazole is a potent, selective and orally active fungal CYP51 (Kd= 0.5 nM) inhibitor, but shows less inhibitory activity on human aromatase (IC50=0.92 μM). Mefentrifluconazole is a novel azole derivative and ... | |||
T1650 | Chlorzoxazone | Paraflex,Chlorzoxazon | P450 , Potassium Channel |
Chlorzoxazone (Chlorzoxazon) is a Muscle Relaxant. The physiologic effect of chlorzoxazone is by means of Centrally-mediated Muscle Relaxation. | |||
T14841 | BVT948 | Phosphatase , P450 , Histone Methyltransferase | |
BVT948 is a protein tyrosine phosphatase (PTP) inhibitor. It can also inhibit several CYP450 isoforms and lysine methyltransferase SETD8 (KMT5A). | |||
T40732 | TMPD dihydrochloride | ||
TMPD dihydrochloride is an active substrate of enzymatically convert redox and an electron donor for the reduction of heme peroxidases. | |||
T16412 | Oteseconazole | VT-1161 | P450 , Antifungal |
Oteseconazole (VT-1161) is an orally active anti-fungal agent. Oteseconazole displays no obvious effect on human CYP51. It also potently binds to and inhibits Candida albicans CYP51 (Kd, <39 nM). | |||
T1491 | Atovaquone | Atavaquone | Others , P450 , Dehydrogenase , Antibiotic , Parasite |
Atovaquone (Atavaquone) is a hydroxynaphthoquinone that has antimicrobial activity and is being used in antimalarial protocols. | |||
T6260 | AMG-208 | AMG 208 | P450 , c-Met/HGFR |
AMG-208 is a highly selective c-Met inhibitor with IC50 of 9 nM. Phase 1. | |||
T7788 | 2-Phenyl-2-(1-piperidinyl)propane | Others | |
2-Phenyl-2-(1-piperidinyl)propane (PPP), an analog of phencyclidine | |||
T22119 | NS3694 | Apoptosis | |
NS3694 is an inhibitor of apoptosis and inhibits apoptosome formation and caspase activation. | |||
T7618 | Pyributicarb | TSH-888 | P450 |
Pyributicarb (TSH-888) is a potent activator of both CYP3A4 gene and human pregnane X receptor (hPXR). | |||
T6216 | Abiraterone | CB-7598 | P450 |
Abiraterone (CB-7598) (CB-7598) is an effective steroidal cytochrome P450 17alpha-hydroxylase-17, 20-lyase (CYP17) inhibitor (IC50: 4 nM). | |||
T9043 | AS1810722 | P450 , STAT | |
AS1810722, a fused bicyclic pyrimidine derivative, is an orally active and potent inhibitor of STAT6, demonstrating an IC50 of 1.9 nM. It exhibits effective inhibition of CYP3A4, positioning it as a promising candidate f... | |||
T3585 | TMS | (E)-2,3',4,5'-tetramethoxystilbene,2,3',4,5'-Tetramethoxystilbene | P450 |
TMS (2,3',4,5'-Tetramethoxystilbene) is a very selective and potent competitive inhibitor of P450 1B1 (CYP1A1). | |||
T1403 | Climbazole | BAY-e 6975 | Antibiotic , Antifungal |
Climbazole (BAY-e 6975) is a broad-spectrum imidazole antifungal agent with anti-dandruff benefits. | |||
T4498 | Stiripentol | BCX2600,Diacomit | P450 |
Stiripentol (BCX2600) (STP) is an anticonvulsant agent, which can inhibit N-demethylation of CLB to NCLB mediated by CYP3A4 (noncompetitively) and CYP2C19 (competitively) with Ki of 1.59/0.516 μM and IC50 of 1.58/3.29 μM... | |||
T1149 | Fenofibrate | Procetofen,Lipanthyl,Lipantil | P450 , PPAR , Autophagy |
Fenofibrate (Lipanthyl) is a peroxisome proliferator receptor alpha agonist. Fenofibrate is a synthetic phenoxy-isobutyric acid derivate and prodrug with antihyperlipidemic activity. | |||
T2196 | Fipronil | Fluocyanobenpyrazole,Termidor | P450 , GluCls , GABA Receptor |
Fipronil (Fluocyanobenpyrazole) is a broad-use insecticide that belongs to the phenylpyrazole chemical family. Fipronil is a broad-spectrum insecticide that disrupts the insect central nervous system by blocking GABA-gat... | |||
T4188 | SDZ285428 | SDZ285-428 | P450 , Parasite , Antifungal |
SDZ285428 is a CYP24A1 inhibitor. | |||
T12171 | Nampt-IN-5 | P450 , NAMPT | |
Nampt-IN-5 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) . | |||
T5953 | 1-Aminobenzotriazole | 3-Aminobenzotriazole,ABT | P450 |
1-Aminobenzotriazole (ABT) (ABT) is a non-specific cytochrome P450 (CYP) inhibitor. | |||
T1434 | Clarithromycin | A-56268 | P450 , ribosome , MRP , Antibacterial , Antibiotic , Autophagy |
Clarithromycin (A-56268) is a Macrolide Antimicrobial. The mechanism of action of clarithromycin is as a Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 3A Inhibitor, and P-Glycoprotein Inhibitor. The chemical classif... | |||
T0922 | Zoxazolamine | NSC 24995,Contrazole | Others |
Zoxazolamine (NSC-24995) is a uricosuric and muscle relaxant. Zoxazolamine acts centrally as a muscle relaxant, but the mechanism of its action is not understood. | |||
T21425 | Mephenytoin | Mesantoin,Methoin,Insulton,Phenantoin,Methylphenetoin | P450 |
Mephenytoin (Phenantoin) is an anticonvulsant and a substrate of CYP2C19 and CYP2B6. | |||
T13601 | CDD3506 | 1-TRITYL-1H-IMIDAZOL-4-AMINE | P450 |
CDD3506 (1-TRITYL-1H-IMIDAZOL-4-AMINE) increases high-density lipoprotein cholesterol by targeting hepatic CYP3A. | |||
T13600 | CDD3505 | 4-nitro-1-trityl-1H-imidazole | P450 |
CDD3505 (4-nitro-1-trityl-1H-imidazole) increases high-density lipoprotein cholesterol by targeting hepatic CYP3A. | |||
T0865 | Ranitidine Hydrochloride | AH19065 | P450 , Antibacterial , Histamine Receptor |
Ranitidine Hydrochloride (AH19065) is a member of the class of histamine H2-receptor antagonists with antacid activity. Ranitidine is a competitive and reversible inhibitor of the action of histamine, released by enteroc... | |||
T7370 | Talarozole | R115866 | Others , P450 , Retinoid Receptor , Autophagy |
Talarozole (R115866) is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA). Talarozole inhibits both CYP26A1 and CYP26B1 with IC50s of 5.4 and 0.46 nM, respectively.Talarozole for the treatment of... | |||
T6215 | Abiraterone Acetate | Zytiga,CB7630 | P450 |
Abiraterone Acetate (CB7630) is an androstene derivative that inhibits STEROID 17-ALPHA-HYDROXYLASE and is used as an ANTINEOPLASTIC AGENT in the treatment of metastatic castration-resistant PROSTATE CANCER. | |||
T21818 | Pregnenolone Carbonitrile | Pregnenolone 16α-carbonitrile ,5-Pregnen-3β-ol-20-one-16α-carbonitrile | P450 |
Pregnenolone Carbonitrile (5-Pregnen-3β-ol-20-one-16α-carbonitrile) is an activator of rodent-PXR and induces the expression of CYP3A. | |||
T2088 | APD668 | APD 668 | GPR , P450 , Potassium Channel |
APD668 is a potent GPR119 agonist with EC50 of 2.7 nM and 33 nM for hGPR119 and ratGPR119, respectively. | |||
T2397 | Topiroxostat | FYX-051 | P450 , ROS , Xanthine Oxidase |
Topiroxostat (FYX-051) is a selective xanthine oxidase inhibitor developed for treatment and management of hyperuricemia and gout. | |||
T9054 | RO6889678 | HBV | |
RO6889678 is HBV inhibitor with a complex ADME profile. | |||
T3610 | Ranitidine | HSDB 3925,Ranitidin | P450 , Antibacterial , Histamine Receptor |
Ranitidine (HSDB 3925) is a non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers. | |||
T6246 | Cobicistat | Tybost,GS-9350 | P450 , HIV Protease |
Cobicistat (GS-9350) is a carbamate and thiazole derivative that functions as a CYTOCHROME P450 CYP3A INHIBITOR to enhance the concentration of ANTI-HIV AGENTS, with which it is used in combination, for the treatment of ... |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T6S1894 | Linderane | P450 | |
1. Linderane was characterized as a mechanism-based inactivator of CYP2C9. | |||
T3818 | Fraxinol | Others , P450 | |
Fraxinol is a predicted metabolite generated by BioTransformer¹ that is produced by the metabolism of 5, 7-dimethoxy-2h-chromen-2-one. It is generated by cyp1a2, cyp2a6, cyp2b6, cyp2c9, cyp2c19, and cyp2e1 enzymes via an... | |||
T3696 | Polygalaxanthone III | Others , P450 | |
Polygalaxanthone III can significantly inhibit chlorzoxazone 6-hydroxylation catalyzed by CYP2E1. | |||
T7970 | 7-Ethoxycoumarin | Others | |
7-Ethoxycoumarin, a typical human P450 substrate, is catalyzed by both wild-type and mutant forms of CYP102A1. | |||
T3669 | Curcumenol | (+)-Curcumenol | P450 |
Curcumenol ((+)-Curcumenol), one of the major components of Zedoary turmeric oil, is an antibiotic drug which has anti-Y, anti-inflammation activity. Curcumenol may be safely used without inducing metabolic drug-drug int... | |||
T5594 | Cedrol | P450 , Antifungal | |
Cedrol is a cedrane sesquiterpenoid and a tertiary alcohol,Cedrol inhibits the cytochrome P450 (CYP) isoforms CYP2B6 and CYP3A4 (Kis = 0.9 and 3.4 μM, respectively) | |||
T37784 | 2,6-Dimethylquinoline | P450 | |
2,6-Dimethylquinoline is a natural product extracted from the roots of Peucedantu praeruptorum. 2,6-Dimethylquinoline is an inhibitor of CYP1A2 and CYP2B6 with an IC50 of 3.3 and 480 µM, respectively. | |||
TN1078 | Seneciphylline | P450 , GST | |
Seneciphylline, one of the hepatotoxic pyrolizidine alkaloids, has mutagenic activity in Drosophila and their transfer into rat milk.Seneciphylline can significantly increased the activities of epoxide hydrase and glutat... | |||
TN1650 | Friedelin | P450 , NOS , Caspase , Prostaglandin Receptor | |
Friedelin possesses antioxidant, gastroprotective, anti-diarrhoeal, liver protective, anti-inflammatory, analgesic and antipyretic activities. | |||
T9503 | PHYTOSPHINGOSINE | Apoptosis | |
Phytosphingosine is a phospholipid with anticancer properties. In cancer cells, Phytosphingosine induces cell apoptosis through activation of caspase 8 and translocation of Bax. | |||
T2854 | Phillyrin | Forsythin | P450 , Influenza Virus , AMPK |
Phillyrin (Forsythin) is a novel AMPK activator, has anti-obesity effects in nutritive obesity mice, it can prevent lipid accumulation in HepG2 cells by blocking the expression of SREBP-1c and FAS through LKB1/AMPK activ... | |||
TQ0191 | Dihydromethysticin | (+)-Dihydromethysticin | P450 |
Dihydromethysticin ((+)-Dihydromethysticin) is a kavalactone found in Piper methysticum. It has marked activity on the induction of CYP3A23. | |||
T8038 | 7-Ethoxy-4-Methylcoumarin | Others | |
7-Ethoxy-4-Methylcoumarin is considered an inhibitor of enzymes in cells and has been used in studies of enzyme inhibition and has been used to study the effects of various drugs on the human body. | |||
T3149 | Salvianolic Acid C | Others , P450 | |
Salvianolic Acid C is extracted from the root of Salvia miltiorrhiza, a perennial plant in the genus Salvia. | |||
T5778 | 5,7-DIMETHOXYFLAVONE | Anti-infection , P450 | |
5,7-DIMETHOXYFLAVONE possessed remarkable leishmanicidal potential. | |||
T0595 | Naringin | Naringoside | Mitophagy , P450 , Endogenous Metabolite , Autophagy |
Naringin (Naringoside), a flavanone glycoside, exerts various of pharmacological effects such as blood lipid lowering, antioxidant activity, anticancer activity, and inhibition of cytochrome P450 enzymes. | |||
T2926 | Schizandrin A | P450 , Virus Protease , Autophagy | |
Schisandrin A, a primary active component extracted from the traditional Eastern medicine Schisandra chinensis, inhibits CYP3A activity, with an IC50 of 6.60 μM and a Ki of 5.83 μM. | |||
T5S2343 | Acetylshikonin | Acetyl shikonin | Others , P450 , AChE |
1. Acetylshikonin exhibits weak cytotoxicity against human umbilical vein endothelial cells (HUVECs) with IC5 of over 2 microM, exhibits the antiangiogenic and antitumorigenic effects by suppressing proliferation and ang... | |||
TN1343 | 8-Geranyloxypsoralen | Anti-infection , P450 , BACE | |
8-Geranyloxypsoralen inhibits α2-secretase (BACE1) activity in non-competitive manner, with the IC(50) values <25.0 μM, it can induce vasorelaxation on rat arterial tissues. 8-Geranyloxypsoralen possesses nematicidal act... | |||
T3776 | Rhapontigenin | Protigenin | P450 , Antibacterial , Antifungal |
Rhapontigenin (Protigenin) is a mechanism-based, selective inactivator of cytochrome P450 1A1 (IC50: 400 nM), an aryl hydrocarbon hydroxylase which activates polycyclic aromatic hydrocarbons that act as procarcinogens. R... | |||
T3668 | Galangin | Norizalpinin,3,5,7-Trihydroxyflavone | ERK , P450 , NF-κB , Autophagy |
Galangin (Norizalpinin) is an agonist/antagonist of the arylhydrocarbon receptor, and also shows inhibition of CYP1A1 activity. | |||
T2770 | Gentiopicroside | Gentiopicrin | P450 , HCV Protease |
Gentiopicroside (Gentiopicrin), a naturally occurring iridoid glycoside, extracted from Gentiana manshurica Kitag, inhibits P450 activity, with an IC50 and a Ki of 61 μM and 22.8 μM for CYP2A6; has antianti-inflammatorya... | |||
T5786 | TETRAHYDROPIPERINE | Cosmoperine | P450 , TRP/TRPV Channel |
Tetrahydropiperine (Cosmoperine) is a natural product derived from piperine, can be used to treat convulsion, epilepsy, relieve pain, and control insects. | |||
T5S0669 | Bergamottin | 5-Geranoxypsoralen,Bergamotine,Bergaptin | P450 |
1. Bergamottin (5-Geranoxypsoralen) can significantly reduce blood glucose and increase glucose tolerance and insulin sensitivity in KK-A<sup>y</sup>diabetic mice. | |||
T1704 | Diosmetin | Luteolin 4-methyl ether | P450 , Trk receptor |
Diosmetin (Luteolin 4-methyl ether) has been found to act as a weak TrkB receptor agonist. | |||
T2143 | Bergapten | 5-Methoxypsoralen | P450 , Autophagy |
Bergapten (5-Methoxypsoralen), a psoralen, inhibits cell replication. | |||
T7938 | Quinidine | Parasite | |
Quinidine is a stereoisomer of the antimalarial agent quinine and a class Ia antiarrhythmic agent. for the treatment of abnormal heart rhythms and also malaria. | |||
TQ0176 | (-)-Isocorypalmine | Tetrahydrocolumbamine,(S)-Tetrahydrocolumbamine | Dopamine Receptor , Antifungal |
(-)-Isocorypalmine ((S)-Tetrahydrocolumbamine), a natural product isolated from Corydalis chaerophylla, has significant antifungal activity. | |||
T11218 | ε-Viniferin | epsilon-Viniferin | P450 |
ε-Viniferin (epsilon-Viniferin) a dimer of resveratrol, shows the inhibitory effects of epsilon-viniferin on human CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2B6, CYP2E1, CYP3A4 and CYP4A activities. | |||
T3736 | Olivetol | 5-Pentylresorcinol,5-n-Amylresorcinol | Cannabinoid Receptor , P450 , IκB/IKK |
Olivetol (5-n-Amylresorcinol) (5-pentylresorcinol, 5-pentyl-1,3-benzenediol) is an organic compound found in certain species of lichen; it is also a precursor in various syntheses of tetrahydrocannabinol. Olivetol has an... | |||
T3401 | Ginsenoside F1 | 20(S)-Ginsenoside F1 | P450 , Endogenous Metabolite |
Ginsenoside F1 (20(S)-Ginsenoside F1) is an enzymatically modified derivative of ginsenoside Rg1, showing competitive inhibition of the activity of CYP3A4 and a weaker inhibition of the activity of CYP2D6. | |||
T2S1434 | Bergaptol | 5-Hydroxyfuranocoumarin,4-Hydroxybergapten,5-Hydroxypsoralen | P450 |
1. Bergaptol (4-Hydroxybergapten) shows very good radical scavenging activity. 2. Bergaptol is a potent inhibitor of debenzylation activity of CYP3A4 enzyme. | |||
T2840 | Phloracetophenone | 2,4,6-trihydroxyacetophenone,1-(2,4,6-Trihydroxyphenyl)ethanone | Others , P450 , Antibacterial , Antibiotic |
Phloracetophenone (1-(2,4,6-Trihydroxyphenyl)ethanone) has antiobesity and hypolipidemic effects, may be partly mediated by delaying the intestinal absorption of dietary fat by inhibiting pancreatic lipase activity. | |||
T3797 | Isosilybin | Isosilybinin,Isosilibinin,Silymarin,Silybin B,Q-100795 | P450 |
Isosilybin (Isosilibinin) and Silybin might be suitable candidates to design potent PXR antagonists to prevent drug-drug interactions via CYP3A4 in cancer patients. | |||
TJS1159 | Chrysosplenetin | Chrysosptertin B | P450 , Ferroptosis , P-gp |
Chrysosplenetin is a metabolic inhibitor of artemisinin. | |||
T1011 | Itraconazole | R51211 | P450 , Hedgehog/Smoothened , Antibiotic , Autophagy , Antifungal |
Itraconazole (R51211) is a triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis. | |||
T3735 | Tetrahydrocurcumin | Sabiwhite,Tetrahydrodiferuloylmethane,HZIV 81-2,Tetrahydro Curcumin | P450 , Endogenous Metabolite , Autophagy |
Tetrahydrocurcumin (HZIV 81-2), a major metabolite of curcumin, has strong antioxidant and cardioprotective properties. | |||
T8079 | α-Terpinyl acetate | Terpinyl Acetate | Others , P450 |
α-Terpinyl acetate is a natural compound found in several essential oils, is a flavouring agent. | |||
TN6848 | Piperonylic acid | 2H-1,3-benzodioxole-5-carboxylic acid | P450 |
Piperonylic acid (2H-1,3-benzodioxole-5-carboxylic acid) is a natural molecule bearing a methylenedioxy function that closely mimics the structure of trans-cinnamic acid. Piperonylic acid selectively inactivate the CYP73... | |||
T7132 | (Rac)-Brassinazole | BRASSINAZOLE | P450 |
(Rac)-Brassinazole are a class of phytohormones with essential roles in plant growth and development, including the promotion of stem elongation and cell division. Brassinazole is a triazole-type brassinosteroid biosynth... | |||
T3811 | Ginsenoside C-K | Ginsenoside compound K,Ginsenoside K | P450 , cell cycle arrest , COX , NO Synthase |
Ginsenoside C-K (Ginsenoside K) is a bacterial metabolite of G-Rb1 exhibiting anti-inflammatory effects by reducing iNOS and COX-2. | |||
T2175 | Apigenin | C.I. Natural Yellow 1,4',5,7-Trihydroxyflavone,NSC 83244,Apigenol,LY 080400 | P450 , Autophagy |
Apigenin (NSC 83244) is an aromatic oil extracted from the flowers or leaves of the daisy-like plants. Extracts, oils and teas made from chamomile are used for its soothing qualities as a sedative, mild analgesic and sle... | |||
T2878 | Ginsenoside Rd | Panaxoside Rd,Sanchinoside Rd,Gypenoside VIII | P450 , Calcium Channel , NF-κB , COX , Endogenous Metabolite |
Ginsenoside Rd (Gypenoside VIII) may have properties that inhibit or prevent the growth of tumors. | |||
T7056 | Dronedarone | SR 33589 | P450 , Potassium Channel , Calcium Channel , Sodium Channel , Adrenergic Receptor , AChR , Autophagy |
Dronedarone (SR 33589) is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation. | |||
T6S0923 | Hypericin | Hypericine,Cyclosan | Apoptosis , Antiviral , Influenza Virus , Tyrosine Kinases , Antibacterial , PKC |
1. Hypericin (Cyclosan) has antineoplastic activity. 2. Hypericin has antibiotic and antiviral activities. 3. Hypericin has antidepressive activity through inhibiting monoamine oxidase enzyme. 4. Hypericin inhibits RANKL... | |||
T8125 | Quinidine sulfate dihydrate | Chinidin Sodium,β-quinine Sodium,Pitayine Sodium,Quinidine sulfate | P450 |
Quinidine sulfate dihydrate (Pitayine Sodium) is a potent and selective cytochrome P450db inhibitor | |||
T5582 | β-Apo-8'-carotenal | trans-β-apo-8'-carotenal,Apocarotenal | Others , P450 |
β-Apo-8'-carotenal (Apocarotenal) is a carotenoid found in spinach and citrus fruits. Apocarotenal is used in fat-based food (margarine, sauces, salad dressing), beverages, dairy products, and sweets. | |||
T6S1917 | Schisandrol B | Gomisin A,TJN-101,Besigomsin,Gamma-Schisandrin,Schizandrol B,Wuweizi alcohol-B | P450 , Reactive Oxygen Species , Autophagy |
1. Schisandrol B (Besigomsin) may exert neuroprotective effects by attenuating the microglia-mediated neuroinflammatory response via inhibiting the TLR4-mediated NF-κB and MAPKs signaling pathways. 2. Schisandrol B has a... | |||
T1548 | Methoxsalen | NCI-C55903,Xanthotoxin,8-Methoxypsoralen,8-MOP | P450 , DNA |
Methoxsalen (NCI-C55903) is a Photoactivated Radical Generator and Psoralen. The mechanism of action of methoxsalen is as a Photoabsorption. The physiologic effect of methoxsalen is by means of Photosensitizing Activity. | |||
T5300 | Ammonium formate | Formic acid ammonium salt | Others |
Ammonium formate (Formic acid ammonium salt) is the simplest carboxylic acid. Formate is an intermediate in normal metabolism. It is responsible for both metabolic acidosis and disrupting mitochondrial electron transport... | |||
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カタログ番号 | 製品名 | Species | Expression System |
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TMPH-00160 | Cytochrome P450 BM-3 Protein, Bacillus megaterium, Recombinant (His & Myc) | Bacillus megaterium | E. coli |
Cytochrome P450 BM-3 Protein, Bacillus megaterium, Recombinant (His & Myc) is expressed in E. coli. | |||
TMPH-02140 | CYP21A2 Protein, Human, Recombinant (E. coli, His) | Human | E. coli |
A cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis. Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11-deoxycorticosterone and 11-d... | |||
TMPH-02141 | CYP21A2 Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) |
A cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis. Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11-deoxycorticosterone and 11-d... | |||
TMPH-01183 | CYP26B1 Protein, Human, Recombinant (His) | Human | E. coli |
CYP26B1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 63.5 kDa and the accession number is Q9NR63. | |||
TMPH-01182 | CYP1A1 Protein, Human, Recombinant (His) | Human | E. coli |
CYP1A1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 63.7 kDa and the accession number is P04798. | |||
TMPJ-01066 | CYCS Protein, Human, Recombinant (His) | Human | E. coli |
Cytochrome C (CYCS) is a small heme protein that belongs to the cytochrome c family. It is found loosely associated with the inner membrane of the mitochondrion. Cytochrome C is a highly soluble protein that functions as... | |||
TMPJ-00723 | CYB5A Protein, Human, Recombinant (His) | Human | E. coli |
Cytochrome b5 (CYB5A) is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases. CYB5A contains one cytochrome b5 heme-binding domain and has two isoforms produced by alt... | |||
TMPH-02618 | CYP2E1 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electr... | |||
TMPH-03017 | CYP51 Protein, Mycobacterium tuberculosis, Recombinant (His & Myc) | Mycobacterium tuberculosis | Baculovirus Insect Cells |
Its precise biological substrate is not known. Catalyzes C14-demethylation of lanosterol, 24,25-dihydrolanosterol and obtusifoliol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethy... | |||
TMPH-03639 | COX7A1 Protein, Trachypithecus cristatu, Recombinant (hFc) | Trachypithecus cristatus | HEK293 Cells |
N/A. COX7A1 Protein, Trachypithecus cristatu, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 31.9 kDa and the accession number is Q9N234. | |||
TMPH-01184 | CYP2A6 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
CYP2A6 Protein, Human, Recombinant (His & Myc) is expressed in E. coli. | |||
TMPH-02617 | COX5A Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli |
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase... | |||
TMPH-01180 | COX5A Protein, Human, Recombinant (GST) | Human | E. coli |
COX5A Protein, Human, Recombinant (GST) is expressed in E. coli. | |||
TMPY-03511 | COX5B Protein, Human, Recombinant (His) | Human | E. coli |
Cytochrome C oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contribut... | |||
TMPH-00956 | Aromatase/CYP19A1 Protein, Human, Recombinant (His) | Human | E. coli |
Aromatase/CYP19A1 Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPH-01186 | CYP2C9 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
CYP2C9 Protein, Human, Recombinant (His & Myc) is expressed in E. coli. | |||
TMPH-03751 | CYBB Protein, Human, Recombinant (His) | Human | E. coli |
Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membr... | |||
TMPH-01185 | CYP2C19 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
CYP2C19 Protein, Human, Recombinant (His & Myc) is expressed in E. coli. | |||
TMPH-01179 | COX4I1 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
COX4I1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPH-02139 | CYP17A1 Protein, Human, Recombinant (GST) | Human | E. coli |
A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen sy... | |||
TMPH-01084 | CYP11A1 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
CYP11A1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 72.1 kDa and the accession number is P05108. | |||
TMPJ-00470 | CYB5B Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Cytochrome b5 type B (CYB5B) is a membrane of the cytochrome b5 family. It contains 1 cytochrome b5 heme-binding domain. Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several mem... | |||
TMPJ-00801 | UQCRH Protein, Human, Recombinant (GST) | Human | E. coli |
Cytochrome b-c1 complex subunit 6, mitochondrial (UQCRH) belongs to the UQCRH/QCR6 family, it is a subunit of the respiratory chain protein Ubiquinol Cytochrome c Reductase. This is a component of the ubiquinol-cytochrom... | |||
TMPH-02801 | CYPOR Protein, Mouse, Recombinant (His) | Mouse | E. coli |
CYPOR Protein, Mouse, Recombinant (His) is expressed in E. coli. | |||
TMPH-01181 | CYP11B2 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
CYP11B2 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPH-01748 | CYPOR Protein, Human, Recombinant (GST) | Human | E. coli |
This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. CYPOR Protein, Human, Recombinant (GST) is expressed in... | |||
TMPY-02652 | CYB5R1 Protein, Human, Recombinant (His) | Human | E. coli |
CYB5R1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 33.5 kDa and the accession number is Q9UHQ9. | |||
TMPY-05321 | CYP3A4 Protein, Human, Recombinant (His) | Human | E. coli |
CYP3A4 is an important member of the cytochrome P450 enzyme superfamily, with 33 allelic variants. Human cytochrome P450 3A4 (CYP3A4) is an important drug metabolizing enzyme involved in a number of drug-drug and food-dr... | |||
TMPY-02700 | BCL2 Protein, Human, Recombinant (His) | Human | E. coli |
BCL2 (B-cell leukemia/lymphoma 2, N-Histidine-tagged), also known as Bcl-2, belongs to the Bcl-2 family. Bcl-2 family proteins regulate and contribute to programmed cell death or apoptosis. It is a large protein family a... | |||
TMPH-00220 | Adrenodoxin, mitochondrial Protein, Bovine, Recombinant (His) | Bovine | E. coli |
Essential for the synthesis of various steroid hormones. Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 th... | |||
TMPH-00021 | Outer membrane protein Omp38, Acinetobacter baumannii, Recombinant (His) | Acinetobacter baumannii | P. pastoris (Yeast) |
Porin. Induces apoptosis in human cells through caspases-dependent and AIF-dependent pathways. Purified Omp38 enters the cells and localizes to the mitochondria, which leads to a release of proapoptotic molecules such as... | |||
TMPH-03513 | Plastocyanin Protein, Spinacia oleracea, Recombinant (His & SUMO) | Spinacia oleracea | E. coli |
Participates in electron transfer between P700 and the cytochrome b6-f complex in photosystem I. Plastocyanin Protein, Spinacia oleracea, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SU... | |||
TMPH-00535 | Epstein-Barr virus (strain B95-8) BHRF1 Protein (His) | EBV | E. coli |
Prevents premature death of the host cell during virus production, which would otherwise reduce the amount of progeny virus. Acts as a host B-cell leukemia/lymphoma 2 (Bcl-2) homolog, and interacts with pro-apoptotic pro... | |||
TMPH-00022 | Outer membrane protein Omp38, Acinetobacter baumannii, Recombinant (His & SUMO) | Acinetobacter baumannii | E. coli |
Porin. Induces apoptosis in human cells through caspases-dependent and AIF-dependent pathways. Purified Omp38 enters the cells and localizes to the mitochondria, which leads to a release of proapoptotic molecules such as... | |||
TMPH-01898 | PARL Protein, Human, Recombinant (Myc) | Human | E. coli |
Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apopt... | |||
TMPY-00924 | SMAC Protein, Human, Recombinant (His) | Human | E. coli |
Apoptosis is an essential processes required for normal development and homeostasis of all metazoan organisms. Second Mitochondria-Derived Activator of Caspases (Smac) or Direct IAP Binding Protein with low isoelectric p... | |||
TMPK-00992 | SEZ6L2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Seizure-related 6 homolog (mouse)-like 2 (SEZ6L2) was shown to be involved in transcription of a type 1 transmembrane protein for regulating cell fate. SEZ6L2 was significantly up-regulated in tumour tissues of patients ... | |||
TMPH-00023 | Outer membrane protein Omp38, Acinetobacter baumannii, Recombinant (His & Myc) | Acinetobacter baumannii | E. coli |
Functions as a porin. Induces apoptosis in human cell lines through caspase-dependent and AIF-dependent pathways. Purified Omp38 enters host cell and localizes to the mitochondria, which presumably leads to a release of ... | |||
TMPY-03412 | GGCT Protein, Human, Recombinant (His) | Human | E. coli |
GGCT belongs to the gamma-glutamylcyclotransferase family. It catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism. GGCT may play a significant role in ... | |||
TMPJ-01407 | FIS1 Protein, Human, Recombinant (His) | Human | E. coli |
Mitochondrial Fission 1 Protein (FIS1) is a member of the FIS1 family. FIS1 is a single-pass membrane protein and contains one TPR repeat. FIS1 is part of the mitochondrial complex that promotes mitochondrial fission. FI... | |||
TMPJ-00848 | NCF1 Protein, Human, Recombinant (His) | Human | E. coli |
Neutrophil cytosol factor 1( NCF1) is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is characterized as a multicomponent enzyme which is activated to produce superoxide anion. NCF2, NCF1, and a mem... | |||
TMPY-03658 | ETHE1 Protein, Human, Recombinant (His) | Human | E. coli |
ETHE1, also known as HSCO, is a sulfur dioxygenase that localizes within the mitochondrial matrix. ETHE1 probably plays an important role in metabolic homeostasis in mitochondria. It may also function as a nuclear-cytopl... | |||
TMPJ-01411 | HSPB11 Protein, Human, Recombinant (His) | Human | E. coli |
Heat Shock Protein β-11 (HSPB11) is a stress-responsive protein that is required to deal with proteotoxic stresses. HSPB11 is composed of an IFT complex B composed of IFT88, IFT57, TRAF3IP1, IFT52, IFT27, HSPB11 and IFT2... | |||
TMPY-02712 | Serpin B3 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
SERPINB3, also known as SCCA-1, belongs to the serpin family. Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was orig... | |||
TMPJ-01020 | GFER Protein, Human, Recombinant (His) | Human | E. coli |
GFER is a hepatotrophic growth factor and flavin-linked sulfhydryl oxidase which belongs to the Erv1/ALR family of proteins. GFER is widely expressed in various human tissues. They are two isoforms of this protein. Isofo... | |||
TMPH-01664 | OMA1 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Activated in response to various mitochondrial stress, leading to the proteolytic cleavage of target proteins, such as OPA... |