|
T23146 |
PHA 568487 free base
|
PHA 568487 |
AChR
|
|
The quinuclidine PHA 568487 free base is an agonist of the alpha 7 nicotinic acetylcholine receptor that was designed to mitigate the bioactivation associated with the core scaffold and subsequently remove associated lia... |
|
T7946 |
AER-271
|
|
Aquaporin
|
|
AER-271 is an inhibitor of aquaporin-4. |
|
T15108 |
DG-041
|
|
Prostaglandin Receptor
|
|
DG-041 is an antagonist of high-affinity EP3 receptor (IC50s: 4.6 nM and 8.1 nM in the binding and FLIPR assay, respectively). DG-041 inhibits PGE2 facilitation of platelet aggregation and has the blood-brain barrier per... |
|
T8887 |
2'MeO6MF
|
|
GABA Receptor
|
|
2'MeO6MF is a brain-penetrant positive allosteric modulator at α2β1γ2L and all α1-containing GABAA receptors.It offers neuroprotection and improved functional recovery and dampens the stroke-induced inflammatory response... |
|
T21635 |
PD184161
|
|
MEK
|
|
PD184161 is a novel, orally-active MEK inhibitor. PD184161 inhibited MEK activity (IC50 = 10-100 nM) in a time- and concentration-dependent manner[1]. |
|
T39341 |
FCPR03
|
|
PDE
|
|
FCPR03 is a selective inhibitor of phosphodiesterase 4 (PDE4) with IC50s of 31 nM, 47 nM, and 60 nM for PDE4B1, PDE4D7, and PDE4 catalytic domain, respectively. FCPR03 has neuroprotective, anti-inflammatory, and antidepr... |
|
T9820 |
GPI-1485
|
GM1485 |
Others
|
|
GPI-1485 (GM1485) (GM1485) is a nonimmunosuppressive immunophilin ligand, promoting neurofunctional improvement and neural regeneration following stroke. |
|
T7512 |
BMS-191011
|
BMS-A |
Potassium Channel
|
|
BMS-191011 (BMS-A) is an activator of large-conductance calcium-activated potassium (BKCa) channels ,effective in stroke models |
|
T3074 |
CHIR 98024
|
CHIR98014 |
GSK-3
,
S6 Kinase
|
|
CHIR 98024 is a potent GSK-3α/β inhibitor with IC50 of 0.65 nM/0.58 nM in cell-free assays, with the ability to distinguish GSK-3 from its closest homologs Cdc2 and ERK2. |
|
T6581 |
Methyclothiazide
|
Duretic,Enduron,Aquatensen |
Others
,
Carbonic Anhydrase
|
|
Methyclothiazide (Aquatensen) is a substituted benzothiadiazide, used to treat high blood pressure and fluid retention caused by various conditions including heart disease. |
|
T8408 |
GKT136901
|
AK120765 |
NADPH-oxidase
,
NADPH
|
|
GKT136901 (AK120765) is an inhibitor of NOX1/4.It acts as Selective and Direct Scavenger of Peroxynitrite |
|
T1057 |
Azilsartan
|
TAK-536 |
RAAS
|
|
Azilsartan (TAK-536) is an Angiotensin 2 Receptor Blocker. The mechanism of action of azilsartan is as an Angiotensin 2 Type 1 Receptor Antagonist. The physiologic effect of azilsartan is by means of Decreased Blood Pres... |
|
T0368 |
Cinepazide maleate
|
MD-67350,Vasodistal,Brendil |
Calcium Channel
|
|
Cinepazide maleate (MD-67350), a maleate salt form of cinepazide, is a vasodilator. |
|
T6504 |
Flupirtine maleate
|
Katadolon maleate |
Potassium Channel
,
NMDAR
,
iGluR
|
|
Flupirtine maleate (Katadolon maleate), a centrally acting non-opioid analgesia, is the salt form of Flupirtine. It is an NMDA receptor antagonist , and also a specific neuronal potassium channel opener. |
|
T2368 |
Edoxaban Tosylate Monohydrate
|
DU-176b,DU-176b tosylate Monohydrate,Lixiana,Edoxaban |
Factor Xa
,
Thrombin
|
|
Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention. |
|
T1101 |
Minocycline hydrochloride
|
Minocycline HCl |
HIF/HIF Prolyl-Hydroxylase
,
Antibacterial
,
Antibiotic
|
|
Minocycline hydrochloride (Minocycline HCl) is a tetracycline antibiotic with excellent absorption and tissue penetration that is used for several bacterial infections as well as treatment of acne. Minocycline hydrochlor... |
|
T6651 |
Safinamide mesylate
|
PNU-151774E,FCE28073,PNU-151774E,NW-1015,EMD 1195686 mesylate |
MAO
,
Monoamine Oxidase
|
|
Safinamide mesylate (EMD 1195686 mesylate) , a mesylate salt of Safinamide, can reversibly and specifically inhibit MAO-B (IC50: 98 nM), has 5918-fold selectivity against MAO-A. |
|
T26645 |
Aptiganel
|
CNS 1102,CNS-1102,CNS1102 |
NMDAR
|
|
Aptiganel (CNS-1102) is a non-competitive NMDA antagonist, a peptide that may be used to study acute ischemic stroke. |
|
T77442 |
Glenzocimab
|
ACT017 |
Others
|
|
Glenzocimab (ACT017) is a Fab fragment of a humanized anti-GPVI monoclonal antibody. Glenzocimab demonstrated inhibition of collagen-induced platelet aggregation in an ischemic stroke model. Glenzocimab has been studied ... |
|
T19659 |
Annaosanchun
|
YC6,YC-6,YC 6 |
Others
,
AMPK
|
|
Annaosanchun (YC-6) is potentially for the treatment of acute ischemic stroke (AIS). |
|
T26389 |
4-POBN
|
NSC-640,NSC640,4-Aminobenzohydrazide,NSC 640,Myeloperoxidase Inhibitor 1,4-ABAH |
Glutathione Peroxidase
|
|
4-POBN (Myeloperoxidase Inhibitor 1) is a potent and irreversible inhibitor of myeloperoxidase (IC50 = 0.3 µM). 4-POBN can be used in studies about subacute stroke. |
|
T16286 |
Nelonemdaz
|
Salfaprodil free base,Neu2000 |
Antioxidant
,
NMDAR
|
|
Nelonemdaz (Neu2000) is an NMDA receptor antagonist with antioxidant activity and neuroprotective activity used in the study of cerebral infarction reperfusion injury and acute ischemic stroke. |
|
T27830L |
Lifarizine FA
|
Lifarizine FA(119514-66-8 Free base) |
Sodium Channel
|
|
Lifarizine FA is a sodium channel blocker used in the treatment of neurological disorders and cardiovascular diseases, study of stroke. |
|
T24873 |
TGX-115
|
TGX 115 |
PI3K
|
|
TGX-115 is a cell-permeable and potent inhibitor of the PI 3-K isoform p110β/p110δ (IC50 values of 0.13 μM for p110β and 0.63 μM for p110δ), an enzyme that regulates platelet adhesion and inhibits phosphoinositide (PI) 3... |
|
T14842 |
BW 245C
|
BW245C |
Prostaglandin Receptor
|
|
BW 245C is a selective prostaglandin-like DP receptor (DP1) agonist, a prostaglandin analogue with inhibitory effects on the aggregation response of collagen, which can be used to study diseases such as stroke. |
|
T7355 |
IC87201
|
|
Others
,
iGluR
|
|
IC87201 is a nNOS-PDZ/PSD-95-PDZ inhibitor. IC87201 showed great promise in cellular experiments and animal models of ischemic stroke and pain. |
|
T3527 |
TRC051384
|
TRC 051384 |
HSP
|
|
TRC051384 is a heat shock protein 70 (HSP70) inducer that reduces stroke-associated neuronal damage and increases survival in a rat model of transient ischemic stroke, activates heat shock factor-1 and leads to elevated ... |
|
T22492 |
2-BFI hydrochloride
|
|
Imidazoline Receptor
|
|
2-BFI hydrochloride is a high-affinity agonist of I2-imidazoline receptor. 2-BFI hydrochloride can be used in studies about protection against stroke and acute inflammatory immune disease. |
|
T39463 |
Asundexian
|
BAY 2433334,Asundexian,BAY2433334,BAY-2433334 |
Factor Xa
|
|
Asundexian (BAY-2433334) is a potent and orally active inhibitor of the coagulation factor FXIa that directly and reversibly binds to the active site of FXIa, thereby inhibiting its activity.Asundexian has an IC50 of 1 n... |
|
T90611 |
PF-03049423
|
|
|
|
PF-03049423 is a potent and highly selective phosphodiesterase-5A inhibitor with an IC50 of approximately 0.2 nM for rat and human thrombomodulin. PF-03049423 can be used in studies about acute ischemic stroke studies. |
|
T16977 |
Talampanel
|
GYKI-53773,LY-300164 |
Apoptosis
,
GluR
|
|
Talampanel (LY-300164) is an orally and selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor antagonist with anti-seizure activity. Talampanel (IVAX) has neuroprotective effects in rodent stroke models. |
|
T3597 |
Cutamesine dihydrochloride
|
AGY94806 dihydrochloride,SA4503 (dihydrochloride),SA4503 dihydrochloride |
Sigma receptor
|
|
Cutamesine dihydrochloride (SA4503 dihydrochloride) is a selective σ1 receptor agonist (IC50: 17.4 nM). It shows selectivity for σ1 over σ2 receptors, and inhibits angiotensin II-induced cardiomyocyte hypertrophy in vitr... |
|
T22798 |
Gavestinel
|
GV 150526,Gavestinel sodium salt |
NMDAR
,
iGluR
|
|
Gavestinel (GV 150526) is a non-competitive NMDA receptor antagonist that is potent, selective and orally active.Gavestinel binds to the glycine site of the NMDA receptor with a binding affinity (pKi value) of 8.5.Gavest... |
|
T50021 |
3-(3,6-dichloro-9H-carbazol-9-yl)propanoic acid
|
|
Others
|
|
3-(3,6-dichloro-9H-carbazol-9-yl)propanoic acid (DCPPA) is an ASIC3 inhibitor that effectively blocks ASIC3-mediated pain and inflammation. It has been shown to have potential applications in the treatment of other disea... |
|
T73447 |
NP10679
|
|
P450
,
HER
,
NMDAR
,
Histamine Receptor
|
|
NP10679 is an orally available, selective, brain-penetrating, potent, and pH-sensitive N-methyl-D-aspartate (NMDA) receptor inhibitor of the GluN2B subunit.NP10679 inhibits histamine H1, hERG channels, and CYP enzymes, a... |
|
T28978 |
Tirilazad mesylate
|
U-74006 mesylate,U74006 mesylate,U 74006 mesylate,U 74006F mesylate,U-74006F mesylate,U74006F mesylate |
Antiviral
|
|
Tirilazad mesylate (U 74006F) is a non-glucocorticoid, lipid peroxidation inhibitor with antiviral activity and neuroprotective activity.Tirilazad mesylate confines intracellular intramembranous foci, attenuates spinal c... |
|
T66256 |
Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate
|
|
Factor Xa
|
|
Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate has an inhibitory effect on coagulation factor Xa, and it can be used in the study of thrombop... |
|
T21757 |
BRL 52537 hydrochloride
|
|
Opioid Receptor
|
|
BRL 52537 hydrochloride is a selective and specific KOR agonist which has been implicated in neuroprotection from ischemic neuronal injury[1]. It is used for research into potential treatments for stroke and heart attack... |
|
T6295 |
Dabigatran
|
BIBR 953,BIBR 953ZW |
Thrombin
|
|
Dabigatran (BIBR 953ZW) is a THROMBIN inhibitor which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation. It is used to reduce the risk of stroke and systemic EMBOLISM in patients... |
|
T61934 |
Repinotan
|
BAY x 3702 free base |
5-HT Receptor
|
|
Repinotan (BAY x 3702 free base) is an orally active and selective 5-HT1A receptor agonist that crosses the blood-brain barrier (BBB), has neuroprotective activity, antagonizes morphine-induced depression of ventilation ... |
|
TP1937L1 |
RFRP-1 (human) acetate(311309-25-8 free base)
|
|
Neuropeptide Y Receptor
|
|
RFRP-1 (human) acetate is a potent endogenous NPFF receptor agonist (EC50 values are 0.0011 and 29 nM for NPFF2 and NPFF1, respectively). Attenuates contractile function of isolated rat and rabbit cardiac myocytes. Reduc... |
|
T13112 |
Tat-NR2B9c
|
Tat-NR2Bct,NA-1 |
NO Synthase
,
iGluR
|
|
Tat-NR2B9c (NA-1) is a postsynaptic density-95 (PSD-95) inhibitor with neuroprotective and antiepileptic effects.Tat-NR2B9c inhibits PSD-95d2, PSD-95d1, and PSD-95, which prevents the activation of NMDA-induced NADPH oxi... |
|
T1613 |
Hydralazine hydrochloride
|
Hydralazine HCl,Apresoline |
MAO
,
HIF/HIF Prolyl-Hydroxylase
|
|
Hydralazine hydrochloride (Apresoline) is the hydrochloride salt of hydralazine, a phthalazine derivative with antihypertensive and potential antineoplastic activities. Hydralazine alters intracellular calcium release an... |
|
T78141 |
LFHP-1c
|
|
Phospholipase
|
|
LFHP-1c, a neuroprotective PGAM5 inhibitor, demonstrates efficacy in preserving blood-brain barrier integrity following ischemic stroke. It achieves this by binding to endothelial PGAM5, thereby inhibiting its phosphatas... |
|
T31206 |
Darexaban
|
YM 150,Darexaban, Tanexaban,YM150 |
Factor Xa
|
|
Darexaban (Tanexaban, YM-150) is a direct inhibitor of Factor Xa.Darexaban and Darexaban glucuronide selectively and competitively inhibit FXA and inhibit prothrombin activity at the site of blood clot (thrombus) formati... |
|
T3637 |
Pifithrin-β hydrobromide
|
Cyclic PFT-α,PFT-β,Cyclic Pifithrin-α hydrobromide,Pifithrin-β,PFT β (hydrobromide) |
Ferroptosis
,
p53
|
|
Pifithrin-β hydrobromide (Cyclic PFT-α) is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorder... |
|
T3560 |
Desmethylanethol trithione
|
ADT-OH |
VEGFR
,
Akt
|
|
Desmethylanethol trithione (ADT-OH) is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. In the in vitro glucose-oxygen deprivation (OGD) model, Desmethylanethol trithione markedly... |
|
T1551 |
Tegaserod maleate
|
HTF-919,SDZ-HTF-919 |
5-HT Receptor
|
|
Tegaserod maleate (SDZ-HTF-919) is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. Its use was the only drug approved by the United States Food and Drug ... |
|
T70540 |
Pinokalant
|
LOE-908 |
SARS-CoV
,
TRP/TRPV Channel
|
|
Pinokalant (LOE-908) is a novel non-selective cation channel inhibitor.Pinokalant significantly reduces cortical infarct volume in in vivo experiments, improves the metabolic and electrophysiological status of the ischem... |
|
T14390L |
(2R,3S)-Azelaprag
|
|
Apelin receptor
|
|
(2R,3S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methylpyridin-3-yl)-4H-1,2,4-triazol-3-yl)-3-(5-methylpyrimidin-2-yl)butane-2-sulfonamide is an Apelin receptor agonist with an EC50 for Apelin receptors of 0.012 µM.(2R,3S)-N-(4-(... |
