| TN1213 |
2-(Hydroxymethyl)anthraquinone
|
|
Anti-infection
|
|
2-(Hydroxymethyl)anthraquinone exhibits strong activity against Helicobacter pylori ATCC 43504 at 0.01 mg/disc. |
| T2946 |
Tanshinone IIA sulfonate sodium
|
Tanshinone IIA sulfonate,Sodium Tanshinone IIA sulfonate,Tanshinone IIA sodium sulfonate,sodium |
CaMK
,
P450
,
Calcium Channel
|
|
Tanshinone IIA sulfonate sodium (Tanshinone IIA sodium sulfonate) is a water-soluble derivative of tanshinone IIA extracted from Savia miltiorrhiza; a potent negative allosteric modulator of the human purinergic receptor... |
| T5S1389 |
Escin IB
|
|
5-HT Receptor
,
NO Synthase
|
|
Escin Ib inhibits gastric emptying, at least in part, mediated by capsaicin-sensitive sensory nerves, to stimulate the synthesis and/or release of dopamine, to act through central dopamine2 receptor, which in turn causes... |
| T8288 |
14-Deoxyandrographolide
|
|
Apoptosis
,
Others
|
|
14-Deoxyandrographolide is a bioactive compound of Andrographis paniculata with hepatoprotective efficacy. It desensitizes hepatocytes to TNF-α-mediated apoptosis through the release of TNFRSF1A release. |
| T13632 |
D-Erythro-dihydrosphingosine
|
Dihydrosphingosine,Octadecasphinganine,C18-Dihydrosphingosine,D-erythro-Sphinganine |
Phospholipase
,
Endogenous Metabolite
|
|
D-Erythro-dihydrosphingosine (C18-Dihydrosphingosine) inhibits arachidonic acid release and cPLA2α activity. |
| T5S1286 |
(+)-Columbianetin
|
(S)-Columbianetin,Columbianetin |
Antifungal
|
|
(+)-Columbianetin ((S)-Columbianetin) is a new phytoalexin associated with celery (Apium graveolens) resistance to pathogens during storage, it also has antifungal activity. (+)-Columbianetin has anti-inflammatory effect... |
| T1297 |
Eugenol
|
4-Allylguaiacol,Allylguaiacol,4-Allyl-2-methoxyphenol,Eugenic acid |
Apoptosis
,
Ferroptosis
,
Reactive Oxygen Species
,
Antibacterial
,
Parasite
|
|
Eugenol (Allylguaiacol) is a Standardized Chemical Allergen. The physiologic effect of eugenol is by means of Increased Histamine Release and Cell-mediated Immunity. |
| T0927 |
Butylparaben
|
Butyl 4-hydroxybenzoate,Butyl parahydroxybenzoate |
Endogenous Metabolite
,
Antibacterial
,
Antibiotic
|
|
Butylparaben (Butyl 4-hydroxybenzoate) is a standardized chemical allergen, increasing histamine release, and cell-mediated immunity. |
| T6956 |
Protirelin
|
Lopremone,pGlu-His-Pro-NH2,Synthetic thyrotropin-releasing hormone,Thyroliberin,TRH,TRF |
Thyroid hormone receptor(THR)
,
Endogenous Metabolite
|
|
Protirelin (Thyroliberin) is a tripeptide that stimulates the release of thyrotropin and prolactin. |
| TCS1188 |
Mogroside III
|
|
Others
|
|
Mogroside III is a triterpenoid glycoside and a nonsugar sweetener. Mogroside III is transformed by human intestinal bacteria to release secondary glycoside mogroside IIA1 and aglycone mogrol. |
| T0908 |
Chlorquinaldol
|
5,7-Dichloro-8-hydroxy-2-methylquinoline,Chloquinan |
Antibacterial
,
Antibiotic
,
Antifungal
|
|
Chlorquinaldol (5,7-Dichloro-8-hydroxy-2-methylquinoline) is a Standardized Chemical Allergen. The physiologic effect of chlorquinaldol is by means of Increased Histamine Release, and Cell-mediated Immunity. |
| T3912 |
Saikosaponin B1
|
|
Others
|
|
Saponin activator. Activates release of Prostaglandin E2 in vitro. Anti-inflammatory agent. Orally active. Active in vivo and in vitro. |
| T3903 |
Angoroside C
|
|
Prostaglandin Receptor
|
|
Angoroside C is a Potential anti-inflammatory compound. Inhibitor of prostaglandin E2 release in mouse peritoneal macrophages in vitro. Shows potent antioxidative activity in reducing the oxidized OH adducts of dAMP and ... |
| T2A2497 |
L-Glutamic acid
|
(S)-Glutamic acid,glutamic acid,(+)-L-Glutamic acid,Aciglut,glutacid,Glutaminol |
Apoptosis
,
Ferroptosis
,
Endogenous Metabolite
,
iGluR
|
|
L-Glutamic acid (Glutaminol) acts as an excitatory transmitter, shows a direct activating effect on the release of DA from dopaminergic terminals. |
| T0834 |
Ethylparaben
|
Ethyl 4-hydroxybenzoate,Ethyl parahydroxybenzoate |
Antibacterial
,
Antifungal
|
|
Ethylparaben (Ethyl parahydroxybenzoate) is a Standardized Chemical Allergen. The physiologic effect of ethylparaben is by means of Increased Histamine Release, and Cell-mediated Immunity. |
| T2793 |
Tetrahydropalmatine
|
DL-Tetrahydropalmatine,Rotundine |
Apoptosis
,
Others
,
Dopamine Receptor
|
|
Tetrahydropalmatine (DL-Tetrahydropalmatine) is an active component isolated from corydalis, suppressing amygdaloid release of dopamine to inhibit an epileptic attack in rats. |
| T4S1876 |
3-Deoxyaconitine
|
|
Sodium Channel
|
|
3- Deoxyaconitine is a derivative of Aconitine (A189875), which activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thus blocking the nerve action potential which, in turn, blocks the rele... |
| TN1154 |
Nepetin
|
6-Methoxyluteolin |
Calcium Channel
,
Histamine Receptor
|
|
Nepetin (6-Methoxyluteolin) has antioxidant activity, it is a potent inhibitor of histamine release and calcium influx via down-regulation of the FcεRI α chain. |
| T7060 |
Amantadine
|
1-Aminoadamantane,1-Adamantanamine,1-Adamantylamine |
Others
|
|
Amantadine (1-Aminoadamantane) is an antiviral, is a weak antagonist of the NMDA-type glutamate receptor, increases dopamine release, and blocks dopamine reuptake. |
| T2S1086 |
Nepitrin
|
Nepetin-7-glucoside |
Antioxidant
|
|
1. Nepitrin (Nepetin-7-glucoside) has antioxidant activity in human HL6 cells assessed as reduction of cytochrome-c release, DPPH free radical scavenging activity, and inhibition of TPA-induced free radical formation. |
| T5758 |
Sphondin
|
|
COX
,
Prostaglandin Receptor
|
|
Sphondin has anticonvulsant, anti-inflammatory, and anti-proliferative activities, it possessed an inhibitory effect on IL-1beta-induced increase in the level of COX-2 protein and PGE(2) release in A549 cells. |
| TN1740 |
Homoeriodictyol
|
|
5-HT Receptor
,
transporter
,
Sodium Channel
,
Drug Metabolite
|
|
Homoeriodictyol, a naturally occurring, bitter-masking flavanone, as a promising agent to increase appetite and food intake. The flavanone homoeriodictyol can increase SGLT-1-mediated glucose uptake but decrease serotoni... |
| TN1081 |
Hirsuteine
|
|
Dopamine Receptor
|
|
Hirsuteine is a natural product. It non-competitively antagonizes nicotine-mediated dopamine release by blocking ion permeation through nicotinic receptor channel complexes. |
| TN6962 |
Docosane
|
|
Others
|
|
Docosane [Standard Material for GC] is a natural product. |
| T3S1641 |
Esculentoside H
|
|
TNF
,
NF-κB
,
JNK
|
|
Phytolaccaceae has anti-tumor activity, the mechanism may be related to the capacity of Esculentoside H for TNF release. |
| T4940 |
3-Methylhistamine dihydrochloride
|
|
Others
,
Endogenous Metabolite
|
|
N tau-methylhistamine is one of the histamine metabolites. N tau-methylhistamine in plasma and urine is a good parameter for histamine release, and the determination of this histamine metabolite is generally less hampere... |
| T9143 |
D-Isoleucine
|
(2R,3R)-2-Amino-3-methylpentanoic acid,(R)-Isoleucine |
Others
|
|
D-Isoleucine ((2R,3R)-2-Amino-3-methylpentanoic acid) is a selective activator of Asc-1 antiporter, which enhances long-term potentiation at the hippocampal CA1-CA3 via release of endogenous D-serine. |
| T6S0840 |
Engeletin
|
Dihydrokaempferol 3-rhamnoside |
NF-κB
,
Reductase
|
|
1. Engeletin (Dihydrokaempferol 3-rhamnoside) may serve as a potential anti-inflammatory agent. 2. Engeletin possesses potent inhibition of PGE2 release with IC5 values of 19.6 μg/ml. 3. Engeletin inhibits a recombinant ... |
| TN1949 |
Moracin C
|
|
ROS
,
NO Synthase
|
|
Moracin C, a natural compound found in Morus mesozygia, Morus alba var. multicaulis, is an anti-inflammatory agent. moracin C inhibits nitric oxide (NO) release and LPS-activated reactive oxygen species (ROS) in cells. |
| T6926 |
Palmitoylethanolamide
|
Mackpeart DR 14V,N-palmitoylethanolamine,Loramine P 256,Impulsin,AM 3112,Palmidrol |
Influenza Virus
,
Endogenous Metabolite
,
PPAR
|
|
Palmitoylethanolamide (Impulsin) is an endogenously fatty acid amide. It has a role as an anti-inflammatory drug, an antihypertensive agent, a neuroprotective agent and an anticonvulsant.Upon administration, palmitoyleth... |
| T0465 |
Ellagic acid
|
Gallogen,Elagostasine |
Hedgehog/Smoothened
,
Casein Kinase
,
Reactive Oxygen Species
,
Topoisomerase
,
Endogenous Metabolite
,
PKA
,
Syk
,
PKC
,
Carbonic Anhydrase
|
|
Ellagic acid (Gallogen) is a fused four ring compound isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clotting system which also causes kinin release; used... |
| TN1721 |
Gypenoside L
|
|
ERK
,
p38 MAPK
,
Calcium Channel
,
NF-κB
,
ROS
|
|
Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release. It also inhibit non-small cell lung carcinoma A549 cell inhibitory a... |
| T3095 |
Tyramine
|
4-hydroxyphenethylamine,para-tyramine,p-Tyramine,mydrial,Tocosine,Uteramine |
MAO
,
Endogenous Metabolite
|
|
Tyramine (Uteramine) is an indirect sympathomimetic that occurs naturally in cheese and other foods. Tyramine does not directly activate adrenergic receptors, but it can serve as a substrate for adrenergic uptake systems... |
| T3902 |
Atractylenolide III
|
ICodonolactone,8β-Hydroxyasterolide |
Apoptosis
|
|
Atractylenolide III (ICodonolactone) may have therapeutic potential in treating homocysteine-mediated cognitive impairment and neuronal injury. Atractylenolide III is a potential candidate for the treatment of human lung... |
| TN1051 |
1-Caffeoylquinic acid
|
|
NF-κB
|
|
1-Caffeoylquinic acid is an important intermediate in lignin biosynthesis. 1-Caffeoylquinic acid has anti-influenza, and antioxidant activities, it also slows the release of glucose into the bloodstream after a meal. |
| T4S0779 |
D-tetrahydropalmatine
|
|
Others
,
Dopamine Receptor
|
|
D-Tetrahydropalmatine is a organic cation transporter 1 (OCT1) inhibitor, it can obviously inhibit the uptake of monocrotaline (MCT) in MDCK-hOCT1 cells and isolate rat primary hepatocytes, and attenuate the viability re... |
| TN7224 |
2,2'-Dihydroxy chalcone
|
|
Antibacterial
,
Autophagy
|
|
2,2'-Dihydroxy chalcone is a potent inhibitor of β-glucuronidase (IC50=1.6±0.2 μM) and lysozyme (IC50=1.4±0.2 μM) release from rat neutrophils stimulated with fMLP/CB.2,2'-Dihydroxy chalcone has inhibitory activity again... |
| TN1065 |
Hirsutine
|
|
Apoptosis
|
|
Hirsutine induces apoptosis and is a potent Dengue virus inhibitor exhibiting low cytotoxicity.Hirsutine has anticancer, cardioprotective, anti-hypertensive and anti-arrhythmic activities, it also has vasodilatation acti... |
| TN1275 |
P-Hydroxyphenethyl anisate
|
4-Hydroxyphenethylanisate |
Others
|
|
p-Hydroxyphenethyl anisate (4-Hydroxyphenethylanisate), a natural product from Notopterygium forbe-siiBoiss, is a novel polymeric sustained-release material that, after block copolymerization with AAPBA, produces nanopar... |
| TN1661 |
Ganoderic acid C2
|
|
Reductase
,
Histamine Receptor
,
Immunology/Inflammation related
|
|
Ganoderic acid C2 has anti-inflammatory,and anti-tumor-promoting activities. Ganoderic acid C2 can inhibit histamine release, it also has inhibitory effects on the induction of Epstein-Barr Virus early antigen. |
| T6S0077 |
Byakangelicol
|
|
COX
|
|
1. Byakangelicol may inhibit P-gp expressed at the BBB even under in vivo conditions. 2. Byakangelicol can inhibit IL-1beta-induced PGE2 release in A549 cells; this inhibition may be mediated by suppression of COX-2 expr... |
| T38248 |
2-Ethylpyrazine
|
|
Endogenous Metabolite
,
NO Synthase
|
|
2-Ethylpyrazine is present in roasted coffee beans and is a volatile compound .2-Ethylpyrazine induces vasodilation through the activity of endothelium-derived relaxing factors.2-Ethylpyrazine activates NO synthesis thro... |
| T3728 |
Methyl Paraben
|
Methyl parahydroxybenzoate,Nipagin,Methylparaben,Methyl 4-hydroxybenzoate,Methyl p-hydroxybenzoate |
Endogenous Metabolite
,
Antibacterial
,
Antibiotic
|
|
The physiologic effect of Methyl Paraben (Nipagin) is by means of Increased Histamine Release, and Cell-mediated Immunity. Methyl Paraben (Nipagin) is an antimicrobial agent, preservative, flavouring agent. Methyl Parabe... |
| TN2080 |
Pinoresinol
|
(+)-Pinoresinol |
Apoptosis
,
NF-κB
,
CDK
,
p53
|
|
Pinoresinol ((+)-Pinoresinol) has antiinflammatory, hepatoprotective, and fungicidal activities, it can protect pial microcirculation from I-reperfusion injury, to increase nitric oxide release and to reduce oxidative st... |
| T1257 |
Bestatin
|
Ubenimex |
Others
,
Aminopeptidase
,
Antibacterial
,
Antibiotic
,
LTR
|
|
Bestatin (Ubenimex) competitively inhibits many aminopeptidases, including B, N and leucine aminopeptidases. Ubenimex is a microbial metabolite and dipeptide with potential immunomodulatory and antitumor activities. Amin... |
| T5227 |
Tricaprin
|
Tridecanoin,Glyceryl tridecanoate,Glycerol Tridecanoate,TG(10:0/10:0/10:0),Glycerol tricaprate |
Others
,
Endogenous Metabolite
|
|
Tricaprin (Glycerol Tridecanoate) is also known as triacylglycerols or triacylglycerides. The triglycerides are rebuilt in the blood from their fragments and become constituents of lipoproteins, which deliver the fatty a... |
| T2909 |
Fraxetin
|
7,8-dihydroxy-6-methoxy coumarin |
Apoptosis
,
Others
|
|
Fraxetin (7,8-dihydroxy-6-methoxy coumarin) has dual-antioxidative ,hepatoprotective and antihyperglycemic functions, it shows potent protective effects against CCl4 induced oxidative stress and hepatic fibrosis, has a m... |
| T1208 |
Citicoline sodium
|
Citicoline sodium salt,CDP-choline |
Apoptosis
,
Others
,
Endogenous Metabolite
|
|
Citicoline sodium (CDP-choline) is an endogenous intermediate in the synthesis of phosphatidylcholine. It also serves as a choline donor in the biosynthesis of the neurotransmitter acetylcholine. Citicoline sodium demons... |
| T4904 |
1-Methylguanidine hydrochloride
|
|
Others
,
Endogenous Metabolite
|
|
Methylguanidine (MG) is a guanidine compound deriving from protein catabolism. It is also a product of putrefaction. Methylguanidine is a suspected uraemic toxin that accumulates in renal failure, however it also exhibit... |
| T3889 |
Platycodin D
|
|
Prostaglandin Receptor
,
AMPK
|
|
Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA. Platycodin D (10/30 μM) suppresses prostaglandin E2 production in rat peritoneal macrophages stimulated by the protein kinase C activator 1... |
