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125

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T81449	PKC-ε translocation inhibitor peptide		PKC
	PKC-ε Translocation Inhibitor Peptide is a selective modulator that controls the FcγR-mediated internalization rate of opsonized beads without affecting FcαR trafficking [1].		PKC
T83727	Tat-NTS Peptide TFA	Tat-Nuclear Translocation Signal Peptide
	Tat-NTS peptide, a cell-penetrating compound, comprises the HIV-1 Tat protein transduction domain fused with a 10-amino acid sequence (residues 228-237) from the repeat III domain of annexin A1, serving as a nuclear tran...
T8423	ML417		Dopamine Receptor , Arrestin
	ML417 is a selective and brain penetrant agonist of D3 Dopamine (EC50 : 38 nM).		Dopamine Receptor , Arrestin
T9216	MLT-943	MLT943	MALT
	MLT-943 is a potent, selective and orally active MALT1 protease inhibitor. [1].		MALT
T11520	GW806742X		MLK , VEGFR
	GW806742X is an inhibitor of Mixed Lineage Kinase Domain-Like protein (MLKL) which binds the MLKL pseudokinase domain (Kd: 9.3 μM) with anti-necroptosis activity. GW806742X has activity against VEGFR2.		MLK , VEGFR
T6207	SC144		Apoptosis , Interleukin
	SC144 is an orally active small-molecule gp130 inhibitor.		Apoptosis , Interleukin
T28362	PF-02413873	PF02413873	Progesterone Receptor
	PF-02413873 is a competitive antagonist of nonsteroidal progesterone receptor with a Ki of 2.6 nM. PF-02413873 can be used in studies about the treatment of gynecological conditions such as endometriosis.		Progesterone Receptor
T36670	JNJ-67856633		MALT
	JNJ-67856633 is an orally active, first-in-class, potent, selective and allosteric inhibitor of MALT1 protease . JNJ-67856633 lead to tumor stasis in some cases.		MALT
T5104	BTSA1		Apoptosis , BCL
	BTSA1 is a BAX activator that binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis.		Apoptosis , BCL
T16040	Mepazine	Pecazine	Apoptosis , MALT
	Mepazine (Pecazine) is a potent and selective inhibitor of MALT1. Mepazine inhibits GSTMALT1 full length and GSTMALT1 325-760 with IC50s of 0.83 μM and 0.42 μM. Mepazine enhances apoptosis and affects the cell viability.		Apoptosis , MALT
T4074	GSK-872	GSK872,GSK'872,GSK2399872A	RIP kinase
	GSK-872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity (IC50: 1.8 nM) and inhibits kinase activity (IC50: 1.3 nM).		RIP kinase
T8730	BMS986260		TGF-beta/Smad
	BMS-986260 is a selective, and orally bioavailable TGFβR1 inhibitor(IC50 = 1.6 nM).		TGF-beta/Smad
T2350	MALT1 inhibitor MI-2	MALT1 inhibitor,MI 2,MI 2 (MALT1 inhibitor)	MALT
	MI-2 (MALT1 inhibitor) is an irreversible MALT1 inhibitor.		MALT
T4420	4-Hydroxytamoxifen	ICI 79280,(Z)-4-hydroxy Tamoxifen,trans-4-Hydroxytamoxifen	Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	4-Hydroxytamoxifen (ICI 79280) is the active metabolite of Tamoxifen, an estrogen receptor modulator (SERM) with selective and oral potency. 4-Hydroxytamoxifen has antitumor activity and may be used in breast cancer rese...		Estrogen Receptor/ERR , Estrogen/progestogen Receptor
T2008	LY294002	LY 294002,NSC 697286,SF 1101	Apoptosis , DNA-PK , Casein Kinase , PI3K , Autophagy
	LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kα, PI3Kδ, and PI3Kβ (IC50=0.5/0.57/0.97 μM). LY294002 is also an inhibitor of DNA-PK (IC50=1.4 μM) and an inhibitor of CK2 (IC50=98 nM). LY294002 ...		Apoptosis , DNA-PK , Casein Kinase , PI3K , Autophagy
T4079	LY-294002 hydrochloride	SF 1101,LY 294002,NSC 697286	PI3K
	LY-294002 hydrochloride (NSC 697286) is a synthetic molecule inhibitor of PI3Kα/δ/β (IC50: 0.5/0.57/0.97 μM, in cell-free assays); more stable than Wortmannin in solution, and also is a blocker of autophagosome formation...		PI3K
T11886	LTβR-IN-1		Others , NF-κB , LTR
	LTβR-IN-1 is a potent and selective lymphin β receptor (LTβR) inhibitor. LTβR-IN-1 has a selective inhibitory effect on the nuclear translocation of p52 of TNF12A, and has no obvious effect on the nuclear translocation o...		Others , NF-κB , LTR
T12942L	SN50 acetate (213546-53-3 free base)		NF-κB
	SN50 acetate is a cell permeable inhibitor of NF-κB translocation.		NF-κB
T6915	Darolutamide	ODM-201,BAY-1841788	Androgen Receptor
	Darolutamide (BAY-1841788) is an androgen receptor (AR) antagonist that blocks AR nuclear translocation (Ki: 11 nM).		Androgen Receptor
T4657	WHI-P97		JAK
	WHI-P97 is a rationally designed potent inhibitor of JAK-3. IC50 value: Target: JAK3 Treatment of mast cells with WHI-P97 inhibited the translocation of 5-lipoxygenase (5-LO) from the nucleoplasm to the nuclear membrane ...		JAK
T33452	ML192	ML-192,CID1434953,CID 1434953,ML 192,CID-1434953	Cannabinoid Receptor , GPR , Arrestin
	ML192 (CID1434953) is a selective GPR55 ligand antagonist. ML192 is an inhibitor that inhibits β-arrestin transport, ERK1/2 phosphorylation, and PKCβII translocation.		Cannabinoid Receptor , GPR , Arrestin
T6308	Stattic	STAT3 Inhibitor V	Apoptosis , STAT
	Stattic (STAT3 Inhibitor V) is a STAT3 inhibitor (IC50=5.1 μM) that selectively inhibits STAT3 activation, dimerization, and nuclear translocation. Stattic has antitumor activity and induces apoptosis.		Apoptosis , STAT
T4022	QS11	QS 11	GTPase
	QS11 is a GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor. Modulates ARF-GTP levels and synergizes with the Wnt/β-catenin signaling pathway to upregulate β-catenin nuclear translocation. Also r...		GTPase
T61531	NFATc1-IN-1		RANKL/RANK
	NFATc1-IN-1 (also known as compound A04) is a highly effective inhibitor of osteoclast formation induced by RANKL, with an IC50 of 1.57 μM. It exerts its anti-osteoclastogenic effects by attenuating the RANKL-induced nuc...		RANKL/RANK
T5845	7ACC1	DEAC,Coumarin D 1421,7-(Diethylamino)coumarin-3-carboxylic acid,D 1421	Monocarboxylate transporter
	7ACC1 (D 142) selectively affects a single part of the MCT symporter translocation cycle, leading to strict inhibition of lactate influx. This singular activity is associated with antitumor effects less prone to resistan...		Monocarboxylate transporter
T64351	GI-560192	RL-0070933	Smo
	GI-560192 (RL-0070933) is a potent smo cilial modulator with an EC50 value of 0.02 µM. GI-560192 modulates the translocation and/or accumulation of smoothened to the primary cilia by hedgehog signaling pathway.		Smo
T11760	KIN101	3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene	HCV Protease , Influenza Virus , RSV , Antifection
	KIN101 (3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene), an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has antiviral activity against RNA viruses, HCV, and R...		HCV Protease , Influenza Virus , RSV , Antifection
T35827L	PKCε Inhibitor Peptide acetate	PKCε Inhibitor Peptide acetate(182683-50-7 Free base)	PKC
	PKCε Inhibitor Peptide acetate is a selective PKCε inhibitor containing the site for its specific receptor for activated C kinase (RACK). PKCε Inhibitor Peptide acetate inhibits the translocation of PKCε, but not α-, β-,...		PKC
T5383	D3-βArr	NCGC00379308	TSH Receptor
	D3-βArr (NCGC00379308) is a positive allosteric modulator for thyrotropin receptor (TSHR), which initiates translocation of β-Arr 1 (EC50: 11.6 μM) by direct TSHR activation.		TSH Receptor
T2274	SC79	SC 79	Akt
	SC79 is an AKT agonist with specificity and blood-brain barrier permeability. SC79 specifically binds to the PH domain of AKT, activates cytoplasmic AKT, and inhibits AKT membrane translocation. SC79 has neuroprotective ...		Akt
T7941	Imipramine hydrochloride	Imipramine (hydrochloride),Tofranil,G 22355,Imipramine HCl,Melipramine	Serotonin Transporter
	Imipramine hydrochloride (Imipramine HCl) is a first generation tricyclic antidepressant that acts primarily as an inhibitor of serotonin and norepinephrine transporters (Kds = 1.4 and 37 nM, respectively).Imipramine hyd...		Serotonin Transporter
T24167	Inflachromene	ICM	Others
	Inflachromene (ICM) is an inhibitor of HMGB1 and HMGB expression with anti-inflammatory activity.Inflachromene reduces seizure severity in a mouse model of epilepsy by inhibiting HMGB1 translocation, inhibits endothelial...		Others
T37020	Endosidin-2	ES2,Endosidin 2
	Endosidin-2 is an exocyst inhibitor, a cell-permeable benzylidene benzoylhydrazine, that binds to the exocyst component of the 70 kDa (EXO70) subunit of the exocyst complex (Kd = 253 μM, EXO70A1).Endosidin-2 disrupts pro...
T33412	MitoPQ	MitoParaquat	Glucokinase , transporter
	MitoPQ (MitoParaquat) is a mitochondria-targeted small molecule compound that selectively enhances mitochondrial superoxide and hydrogen peroxide levels and inhibits insulin-stimulated glucose uptake and translocation of...		Glucokinase , transporter
TP1938L	RS09 2TFA (1449566-36-2 free base)	RS09 2TFA 1449566-36-2(free base)	TLR
	RS09 2TFA (1449566-36-2 free base) is a TLR4 agonist. Promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in vitro. It acts as an adjuvant in vivo and enhances X-15 sp...		TLR
T27240	Eeyarestatin I		Apoptosis
	Eeyarestatin I is an inhibitor that inhibits the degradation and translocation of ER-associated proteins. Eeyarestatin I is associated with the p97 deubiquitination process and inhibits atx3 deubiquitination. Eeyarestati...		Apoptosis
T9266	Fatostatin		Lipid , Fatty Acid Synthase
	Fatostatin is a specific inhibitor of SREBP activation, it impairs the activation of SREBP-1 and SREBP-2. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs.		Lipid , Fatty Acid Synthase
T77332	TV 3279		BCL , PKC
	TV 3279 is a novel ChE-MAI inhibitor , and the neuroprotective properties depend on their ability to induce the anti-apoptotic proteins PKC, Bcl-2, Bcl-x, and SOD, and to block the nuclear translocation of the pro-apopto...		BCL , PKC
T14212	AMG-1694		Glucokinase
	AMG-1694, a potent disruptor of the glucokinase–glucokinase regulatory protein (GK-GKRP) complex, operates by promoting the dissociation of this complex, thereby indirectly enhancing GK enzymatic activity with an IC50 of...		Glucokinase
T19710	Ciglitazone	Ciglitazona,U 63287,ADD3878,ADD-3878,U-63287,ADD 3878	Apoptosis , p38 MAPK , PPAR
	Ciglitazone (ADD 3878) is a potent and selective PPARγ agonist (EC50: 3 μM) and oral hypoglycemic agent. Ciglitazone inhibits proliferation and differentiation of th17 cells, decreases insulin levels, vascular endothelia...		Apoptosis , p38 MAPK , PPAR
T60013	GA-017		Others
	GA-017 is a potent, selective inhibitor of LATS1 and LATS2 (large tumor suppressor kinase 1/2), exhibiting IC50 values of 4.10 and 3.92 nM, respectively. This compound simultaneously acts as an activator of cell prolifer...		Others
T6964	Resiquimod	R848,S28463	HCV Protease , TLR
	Resiquimod (R848) is an imidazoquinoline amine and Toll-like receptor (TLR) agonist with potential immune response modifying activity. Resiquimod exerts its effect through the TLR signaling pathway by binding to and acti...		HCV Protease , TLR
T8055	TFEB activator 1	(1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,,Curcumin analog compound C1,Curcumin analog C1,RPN77612	Others , Autophagy
	TFEB activator 1 (Curcumin analog compound C1) is an activator of transcription factor EB (TFEB) with promise for the prevention or treatment of Alzheimer's disease.		Others , Autophagy
T34963	TSPA
	TSPA is an ATF6α translocation inducer which effectively promotes ATF6α translocation into the nucleus and ameliorates glucose homeostasis on db/db mice.
T12942	SN50		NF-κB
			NF-κB
T25792	Mesoxalic acid	Mesoxalate,Ketomalonic acid,Oxomalonic acid
	Mesoxalic acid is a dicarboxylic acid and a ketonic acid which blocks RT translocation.
T11420	GLUT4 activator 1		Others
	GLUT4 activator 1 is a potent glucose transporter type 4 (GLUT4) translocation activator (EC50: 0.14 μM).		Others
T23583	58-G3	58G3
	58-G3 is an agonist of methuselah (Mth)-specific that acts by inducing dose-dependent calcium elevation and membrane translocation of β-arrestin2.
T71842	D719
	D719 is a novel inhibitor of integrase nuclear translocation, showing significant inhibition on virus p24 antigen production.
T69253	FMP-401319-3
	FMP-401319-3 is a concentration-dependent inhibitor of CRF1R-pPL cotranslational translocation at the level of the Sec61 complex.

Compounds

PKC-ε translocation inhibitor peptide

Synonym: Tat-Nuclear Translocation Signal Peptide

Target: Dopamine Receptor, Arrestin

Target: Apoptosis, Interleukin

PF-02413873

T28362

Synonym: PF02413873

Target: Progesterone Receptor

Target: Apoptosis, BCL

Mepazine

T16040

Synonym: Pecazine

Target: Apoptosis, MALT

GSK-872

T4074

Synonym: GSK872,GSK'872,GSK2399872A

Target: TGF-beta/Smad

MALT1 inhibitor MI-2

T2350

Synonym: MALT1 inhibitor,MI 2,MI 2 (MALT1 inhibitor)

Target: MALT

4-Hydroxytamoxifen

T4420

Synonym: ICI 79280,(Z)-4-hydroxy Tamoxifen,trans-4-Hydroxytamoxifen

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

LY294002

T2008

Synonym: LY 294002,NSC 697286,SF 1101

Target: Apoptosis, DNA-PK, Casein Kinase, PI3K, Autophagy

LY-294002 hydrochloride

T4079

Synonym: SF 1101,LY 294002,NSC 697286

Target: Others, NF-κB, LTR

SN50 acetate (213546-53-3 free base)

Synonym: ODM-201,BAY-1841788

Target: Androgen Receptor

Synonym: ML-192,CID1434953,CID 1434953,ML 192,CID-1434953

Target: Cannabinoid Receptor, GPR, Arrestin

Stattic

T6308

Synonym: STAT3 Inhibitor V

Target: Apoptosis, STAT

Synonym: DEAC,Coumarin D 1421,7-(Diethylamino)coumarin-3-carboxylic acid,D 1421

Target: Monocarboxylate transporter

Synonym: 3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene

Target: HCV Protease, Influenza Virus, RSV, Antifection

PKCε Inhibitor Peptide acetate

T35827L

Synonym: PKCε Inhibitor Peptide acetate(182683-50-7 Free base)

Target: PKC

D3-βArr

T5383

Synonym: NCGC00379308

Imipramine hydrochloride

T7941

Synonym: Imipramine (hydrochloride),Tofranil,G 22355,Imipramine HCl,Melipramine

Target: Serotonin Transporter

Synonym: ES2,Endosidin 2

Target:

MitoPQ

T33412

Synonym: MitoParaquat

Target: Glucokinase, transporter

RS09 2TFA (1449566-36-2 free base)

TP1938L

Synonym: RS09 2TFA 1449566-36-2(free base)

Target: Lipid, Fatty Acid Synthase

Synonym: Ciglitazona,U 63287,ADD3878,ADD-3878,U-63287,ADD 3878

Target: Apoptosis, p38 MAPK, PPAR

Target: HCV Protease, TLR

TFEB activator 1

T8055

Synonym: (1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,,Curcumin analog compound C1,Curcumin analog C1,RPN77612

Target: Others, Autophagy

Synonym: Mesoxalate,Ketomalonic acid,Oxomalonic acid

カタログ番号	製品名	別名	ターゲット
T3947	Nonanoic acid	pelargonic acid,Nonoic acid	Others , Antibacterial
	Nonanoic acid (Nonoic acid) is a fatty acid which occurs naturally as esters are the oil of pelargonium. Synthetic esters, such as methyl nonanoate, are used as flavorings. Pelargonic acid is an organic compound composed...		Others , Antibacterial
T5689	20-DEOXYINGENOL		Others , Autophagy
	20-DEOXYINGENOL is a natual product.		Others , Autophagy
T2S0820	Karanjin		Apoptosis , AMPK
	Karanjin is a flavonoid obtained from the seeds of the karanja tree.Karanjin induces GLUT4 translocation in skeletal muscle cells by increasing AMPK activity. Karanjin can induce cancer cell death through cell cycle arre...		Apoptosis , AMPK
T19768	γ-Tocotrienol	gamma Tocotrienol,gammaTocotrienol,gamma-Tocotrienol,D-gamma-Tocotrienol,Plastochromanol	Others
	γ-Tocotrienol (Plastochromanol) is one of the four types of tocotrienol, a type of vitamin E. Itl is also a radioprotector, antioxidant. It shows antitumor and antihypertensive effects in vivo.		Others
T8771	Pongamol		Others
	Pongamol, an identified lead molecule from the fruits of Pongamia pinnata, on glucose uptake and GLUT4 translocation in skeletal muscle cells.		Others
T9503	PHYTOSPHINGOSINE		Apoptosis
	Phytosphingosine is a phospholipid with anticancer properties. In cancer cells, Phytosphingosine induces cell apoptosis through activation of caspase 8 and translocation of Bax.		Apoptosis
T4S0295	Apigenin 7-glucoside	Cosmetin,Cosmosiin,Cosmosioside,Apigenin-7-O-β-D-glucopyranoside,Thalictiin,Apigetrin	Reactive Oxygen Species , HIV Protease
	1. Apigenin 7-glucoside (Cosmosiin) is a anti-HIV agent. 2. Cosmosiin may be beneficial for diabetic complications through their enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and GLUT4 tr...		Reactive Oxygen Species , HIV Protease
T5701	OPHIOPOGONIN D		RAAS , Calcium Channel , NF-κB , PPAR
	Ophiopogonin D is a natural product,and is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation.		RAAS , Calcium Channel , NF-κB , PPAR
T2212	Geniposide		Beta Amyloid , Influenza Virus
	Geniposide is an iridoid glycoside with a variety of biological activities including neuroprotective, anti-diabetic, antiproliferative, and antioxidative activity. Geniposide has been shown to regulate Nrf2 translocation...		Beta Amyloid , Influenza Virus
T3S1692	Octahydrocurcumin		Anti-infection , NF-κB , Reactive Oxygen Species , ROS
	Octahydrocurcumin has antioxidant and and anti-inflammatory activities, it can inhibit the lipopolysaccharide (LPS)-induced inflammatory response via the mechanism of inhibiting NF-kB translocation to the nucleus. Octahy...		Anti-infection , NF-κB , Reactive Oxygen Species , ROS
TN1100	Nepodin		transporter , COX , AMPK , Parasite
	Nepodin has antimalarial, and anti-inflammatory activities, it shows significant cyclooxygenase (COX) inhibitory activity. Nepodin has an antidiabetic effect, which is at least partly mediated by stimulation of GLUT4 tra...		transporter , COX , AMPK , Parasite
T4237	Rubiadin-1-methyl ether	Rubiadin 1-methyl ether	Anti-infection , NF-κB
	Rubiadin-1-methyl ether (Rubiadin 1-methyl ether) is a natural product.It inhibits osteoclastic bone resorption via inhibition on the phosphorylation of NF-κB p65 and the degradation of IκBα as well as decrease in the nu...		Anti-infection , NF-κB
T1022	Hygromycin B	Hygrovetine	ribosome , Antibacterial , Antibiotic , Antifungal
	Hygromycin B (Hygrovetine) is an aminoglycoside antibiotic that inhibits protein synthesis by interfering with translocation and causing mistranslation of the 70S ribosome. Hygromycin B can be used to screen prokaryotic ...		ribosome , Antibacterial , Antibiotic , Antifungal
T5S1805	5,7-Dihydroxychromone	5,7-Dihydroxy-4H-Chromen-4-One	Others , Virus Protease , PARP , Caspase , Nrf2
	1. 5,7-Dihydroxychromone (5,7-Dihydroxy-4H-Chromen-4-One) isolated from DME is one of the active compounds that may contribute to regulate blood glucose levels. 2. 5,7-Dihydroxychromone exerts neuroprotective effect agai...		Others , Virus Protease , PARP , Caspase , Nrf2
T2836	Isorhamnetin	3-methylquercetin,3'-Methylquercetin,Isorhamnetol,3'-Methoxyquercetin	MEK , PI3K , Endogenous Metabolite
	Isorhamnetin (3-methylquercetin) is the methylated metabolite of quercetin. Quercetin is an important dietary flavonoid with in vitro antioxidant activity. Isorhamnetin prevents endothelial cell injuries from oxidized LD...		MEK , PI3K , Endogenous Metabolite
T0798	Triamcinolone	Fluoxyprednisolone,Aristocort,Rodinolone	Glucocorticoid Receptor , COX
	Triamcinolone (Aristocort) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. Upon cell entry, triamcinolone binds to and activates the glucocorticoid receptor, which leads to transloca...		Glucocorticoid Receptor , COX
TN5364	Boscialin
	Boscialin can inhibit signal transducer and activator of transcription 1 translocation at a concentration of 10 uM.
TN6394	Alisol B acetate
	Alisol B acetate can induce Bax nuclear translocation and apoptosis in human hormone-resistant prostate cancer PC-3 cells, the Bax activation and translocation from the cytosol to nucleus might be a crucial response to t...
TMA0237	Carlinoside		Nrf2
	Carlinoside could be a worthy choice to intervene hyperbilirubinemia due to liver dysfunction. Carlinoside upregulates Nrf2 gene expression, increases its nuclear translocation and stimulates UGT1A1 promoter activity.		Nrf2
T75540	Ipomoeassin F
	Ipomoeassin F, a selective and potent inhibitor of endoplasmic reticulum (ER) protein translocation, targets the Sec61 complex's pore-forming subunit (Sec61α) at the ER membrane. It inhibits the ER membrane translocation...
T11233	Erythromycin thiocyanate		Antibacterial
	Erythromycin thiocyanate acts by binding to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nuc...		Antibacterial
TN2178	Sanggenone H		IL Receptor , TNF , NF-κB
	Sanggenone H may have antiphlogistic activity, it attenuated the secretion of TNF-α± and IL-1α² and inhibited the NF-κB nuclear translocation in LPS-stimulated macrophages.		IL Receptor , TNF , NF-κB
T39077	Aeruginosin 865
	Aeruginosin 865, a compound extracted from the terrestrial cyanobacterium Nostoc sp. Luke ová 30/93, represents the inaugural aeruginosin-type peptide to incorporate a fatty acid and a carbohydrate moiety. It functions b...
T40611	(E)-Dehydrodiconiferyl alcohol
	(E)-Dehydrodiconiferyl alcohol is a potent dual inhibitor of hCA IX and hCA XII, effectively impeding the catalytic activity of both carbonic anhydrase isoforms. Additionally, (E)-Dehydrodiconiferyl alcohol exerts inhibi...
T35895	Ingenol 3,20-dibenzoate
	Ingenol 3,20-dibenzoate is a powerful activator of protein kinase C (PKC) isoforms. It effectively induces the translocation of nPKC-delta, -epsilon, and -theta as well as PKC-mu from the cytosolic fraction to the partic...
TN1009	Epimagnolin B		NF-κB , NO Synthase , Prostaglandin Receptor
	Epimagnolin B has anti-inflammatory activity, it can inhibit the production of NO and PGE(2) and the expression of respective enzyme iNOS and COX-2 through the suppression of I-kappaB-alpha degradation and nuclear transl...		NF-κB , NO Synthase , Prostaglandin Receptor
TMA0127	Ficusin A		transporter , PPAR
	Ficusin has antioxidant, antilipidemic and antidiabetic effects, it can lower the levels of fasting blood glucose, plasma insulin, body weight gain in HFD-STZ induced diabetic rats, and can significantly enhance the PPAR...		transporter , PPAR
TN1347	8-Prenylkaempferol		p38 MAPK , NF-κB , PI3K
	8-Prenylkaempferol is an effective agent for attenuating pro-inflammatory NO induction, it may be an anti-inflammatory agent for suppressing influenza A virus-induced RANTES production acts by blocking PI3K-mediated tran...		p38 MAPK , NF-κB , PI3K
TN4635	Neoechinulin A		NADPH-oxidase , Beta Amyloid , ASK , IκB/IKK , p38 MAPK , TNF , NOS , NF-κB , COX , Prostaglandin Receptor
	Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-ÎºB and p38 MAPK pathways, it may block the phosphorylation of mitogen-activated protein kinase (MAPK) ...

天然物製品

Nonanoic acid

T3947

Synonym: pelargonic acid,Nonoic acid

Target: Others, Antibacterial

20-DEOXYINGENOL

T5689

Synonym:

Target: Others, Autophagy

Karanjin

T2S0820

Synonym:

Target: Apoptosis, AMPK

γ-Tocotrienol

T19768

Synonym: gamma Tocotrienol,gammaTocotrienol,gamma-Tocotrienol,D-gamma-Tocotrienol,Plastochromanol

Synonym: Cosmetin,Cosmosiin,Cosmosioside,Apigenin-7-O-β-D-glucopyranoside,Thalictiin,Apigetrin

Target: Reactive Oxygen Species, HIV Protease

OPHIOPOGONIN D

T5701

Synonym:

Target: RAAS, Calcium Channel, NF-κB, PPAR

Geniposide

T2212

Synonym:

Target: Beta Amyloid, Influenza Virus

Octahydrocurcumin

T3S1692

Synonym:

Target: Anti-infection, NF-κB, Reactive Oxygen Species, ROS

Nepodin

TN1100

Synonym:

Target: transporter, COX, AMPK, Parasite

Rubiadin-1-methyl ether

T4237

Synonym: Rubiadin 1-methyl ether

Target: Anti-infection, NF-κB

Hygromycin B

T1022

Synonym: Hygrovetine

Target: ribosome, Antibacterial, Antibiotic, Antifungal

5,7-Dihydroxychromone

T5S1805

Synonym: 5,7-Dihydroxy-4H-Chromen-4-One

Target: Others, Virus Protease, PARP, Caspase, Nrf2

Isorhamnetin

T2836

Synonym: 3-methylquercetin,3'-Methylquercetin,Isorhamnetol,3'-Methoxyquercetin

Target: MEK, PI3K, Endogenous Metabolite

Triamcinolone

T0798

Synonym: Fluoxyprednisolone,Aristocort,Rodinolone

Target: Glucocorticoid Receptor, COX

Erythromycin thiocyanate

T11233

Synonym:

Target: Antibacterial

Sanggenone H

TN2178

Synonym:

Target: IL Receptor, TNF, NF-κB

(E)-Dehydrodiconiferyl alcohol

T40611

Synonym:

Target:

Ingenol 3,20-dibenzoate

Target: NF-κB, NO Synthase, Prostaglandin Receptor

Ficusin A

TMA0127

Synonym:

Target: transporter, PPAR

8-Prenylkaempferol

TN1347

Synonym:

Target: p38 MAPK, NF-κB, PI3K

Neoechinulin A

TN4635

Synonym:

Target: NADPH-oxidase, Beta Amyloid, ASK, IκB/IKK, p38 MAPK, TNF, NOS, NF-κB, COX, Prostaglandin Receptor

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-03596	JTB Protein, Human, Recombinant (mFc)	Human	HEK293 Cells
	Jumping translocation breakpoint, also known as JTB, is a member of the JTB family. Jumping translocation (JT) is an unbalanced translocation that comprises amplified chromosomal segments jumping to various telomeres. JT...
TMPY-02700	BCL2 Protein, Human, Recombinant (His)	Human	E. coli
	BCL2 (B-cell leukemia/lymphoma 2, N-Histidine-tagged), also known as Bcl-2, belongs to the Bcl-2 family. Bcl-2 family proteins regulate and contribute to programmed cell death or apoptosis. It is a large protein family a...
TMPY-02287	Ku70 & Ku80 Heterodimer Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	X-ray repair cross-complementing protein 5, also known as 86 kDa subunit of Ku antigen, ATP-dependent DNA helicase 2 subunit 2, ATP-dependent DNA helicase II 8 kDa subunit, CTC box-binding factor 85 kDa subunit, DNA repa...
TMPH-03726	YscM Protein, Yersinia pseudotuberculosis serotype I, Recombinant (His & SUMO)	Yersinia pseudotuberculosis	E. coli
	Belongs to an operon involved in the translocation of Yop proteins across the bacterial membranes or in the specific control of this function.
TMPH-03720	YscM Protein, Yersinia enterocolitica, Recombinant (His & SUMO)	Yersinia enterocolitica	E. coli
	Belongs to an operon involved in the translocation of Yop proteins across the bacterial membranes or in the specific control of this function.
TMPH-03010	EsxB Protein, Mycobacterium tuberculosis, Recombinant (His)	Mycobacterium tuberculosis	P. pastoris (Yeast)
	A secreted protein. Acts as a strong host T-cell antigen. Involved in translocation of bacteria from the host (human) phagolysosome to the host cytoplasm. Might serve as a chaperone to prevent uncontrolled membrane lysis...
TMPH-00268	GLTP Protein, Bovine, Recombinant (His)	Bovine	P. pastoris (Yeast)
	Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellu...
TMPH-01691	TOMM40 Protein, Human, Recombinant (GST)	Human	E. coli
	Channel-forming protein essential for import of protein precursors into mitochondria. Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by forming a complex with ...
TMPH-00649	LptA Protein, E. coli, Recombinant (His & SUMO)	E. coli	E. coli
	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interact...
TMPH-03741	BoNT/F Protein, Clostridium botulinum, Recombinant (His)	Clostridium botulinum	E. coli
	Botulinum toxin causes flaccid paralysis by inhibiting neurotransmitter (acetylcholine) release from the presynaptic membranes of nerve terminals of the eukaryotic host skeletal and autonomic nervous system, with frequen...
TMPH-02683	GSTP1 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). ...
TMPH-00694	LolA Protein, E. coli O9:H4, Recombinant (His)	E. coli	P. pastoris (Yeast)
	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targ...
TMPH-01690	TIM14 Protein, Human, Recombinant (GST)	Human	E. coli
	Mitochondrial co-chaperone which forms a complex with prohibitins to regulate cardiolipin remodeling. May be a component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins...
TMPH-03009	EsxB Protein, Mycobacterium tuberculosis, Recombinant (E. coli, His)	Mycobacterium tuberculosis	E. coli
	A secreted protein. Acts as a strong host T-cell antigen. Involved in translocation of bacteria from the host (human) phagolysosome to the host cytoplasm. Might serve as a chaperone to prevent uncontrolled membrane lysis...
TMPH-02536	BNIP3 Protein, Mouse, Recombinant (Cell-Free, His)	Mouse	E. coli
	Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality cont...
TMPH-01399	GSTP1 Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). ...
TMPH-01286	EEF2 Protein, Human, Recombinant (His)	Human	E. coli
	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly form...
TMPJ-01106	NAD(P) transhydrogenase/NNT Protein, Human, Recombinant (His)	Human	E. coli
	NAD(P)+transhydrogenase (NNT) is located in the inner mitochondrial membrane and catalyzes a reversible hydride transfer between NAD(H) and NADP(H) that is coupled to proton translocation between the intermembrane space ...
TMPH-01398	GSTP1 Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). ...
TMPJ-00965	TIM16 Protein, S. cerevisiae, Recombinant	S. cerevisiae	E. coli
	Mitochondrial import inner membrane translocase subunit TIM16 (TIM16) is an ssential component of the PAM complex. PAM complex is required for the translocation of transit peptide-containing proteins from the inner membr...
TMPY-03959	CHST11 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	CHST11, also known as C4ST-1, belongs to the sulfotransferase 2 family. CHST11 localizes to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondro...
TMPH-03507	IpaD Protein, Shigella flexneri, Recombinant (His & Myc & SUMO)	Shigella flexneri	E. coli
	Required for bacterial invasion of host cells. Controls IpaB and IpaC secretion, and the efficiency with which they are physically inserted into target cell membranes. These proteins are exported via TTSS to form a pore ...
TMPH-01522	HIV-2 (subtype A, isolate ROD) Protein Vpx (His)	HIV-2	P. pastoris (Yeast)
	Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by...
TMPK-00668	IL-21R Protein, Cynomolgus, Recombinant (aa 41-254, His)	Cynomolgus	HEK293 Cells
	IL-21 and IL-21R were highly expressed in the lesional skin and peripheral blood of psoriasis patients. IL-21 promoted CD4 T cells proliferation and Th17 cells differentiation and inhibiting Treg cells differentiation by...
TMPY-03455	FGFR1OP Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	FOP( fibroblast growth factor receptor 1 oncogene partner) is a largely hydrophilic protein postulated to be a leucine-rich protein family member. FOP contains 1 LisH domain. A t(6;8)(q27;p11) chromosomal translocati...
TMPJ-01087	TIM14 Protein, S. cerevisiae, Recombinant	S. cerevisiae	E. coli
	Mitochondrial import inner membrane translocase subunit TIM14 (TIM14) is an essential component of the PAM complex. PAM complex is required for the translocation of transit peptide-containing proteins from the inner memb...
TMPY-04406	Protein Kinase D2/PRKD2 Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	Serine/threonine-protein kinase D2, also known as PRKD2 and PKD2, is a cytoplasm and membrane protein that belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family and PKD subfamily. PRKD2 / PKD2 is ...
TMPJ-00376	IL-17RD Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Interleukin-17 receptor D (IL-17 RD), also known as SEF (similar expression to FGFs), is a type I transmembrane protein that is found in both the cytoplasm and plasma membrane. IL-17RD functions as a feedback inhibitor o...
TMPH-02194	TAB2 Protein, Human, Recombinant (His & Myc)	Human	Baculovirus Insect Cells
	Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF). Acts as an adapter linking MAP3K7/TAK1...
TMPH-00542	Epstein-Barr virus (strain Raji) LMP1 Protein (His)	EBV	P. pastoris (Yeast)
	Acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation. Functions as a constitutively active tumor necrosis factor receptor that induces the activation of several s...
TMPJ-00499	GSTP1 Protein, Human, Recombinant	Human	E. coli
	Glutathione S-transferase P (GSTP1) is an enzyme that contains 1 GST C-terminal domain, 1 GST N-terminal domain. GSTP1 belongs to the GST superfamily, the GSTs are a family of enzymes that play an important role in deto...
TMPH-00541	Epstein-Barr virus (strain AG876) LMP1 Protein (His & Myc)	EBV	E. coli
	Acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation. Functions as a constitutively active tumor necrosis factor receptor that induces the activation of several s...
TMPY-03500	ARL2BP Protein, Human, Recombinant (His)	Human	E. coli
	ADP-ribosylation factor (ARF)-like proteins (ARLs) comprise a functionally distinct group of the ARF family of RAS-related GTPases. ARL2BP binds to ARL2.GTP with high affinity but does not interact with ARL2.GDP, activ...
TMPY-04478	IP6K1/IHPK1 Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	IP6K1 (Inositol Hexakisphosphate Kinase 1) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. IHPK1 is an inositol hexaphosphate kinase (IHPK) protein that belongs to the inositol phosph...
TMPJ-00306	SIRP alpha Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	Signal Regulatory Protein α (SIRPα) is a monomeric approximately 90 kD type I transmembrane glycoprotein. The 504 amino acid human SIRPα contains two Ig-like C1-type domains and one Ig-like V-type domain. SIRPα can expre...
TMPH-02538	Beclin-1 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways...
TMPJ-00305	SIRP alpha Protein, Cynomolgus, Recombinant (aa 31-369, His)	Cynomolgus	HEK293 Cells
	Signal Regulatory Protein α (SIRPα) is a monomeric approximately 90 kD type I transmembrane glycoprotein. The 504 amino acid human SIRPα contains two Ig-like C1-type domains and one Ig-like V-type domain. SIRPα can expre...
TMPH-02530	ATP5B Protein, Mouse, Recombinant (His & Myc & SUMO)	Mouse	E. coli
	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respirator...
TMPJ-01182	SIRP alpha Protein, Mouse, Recombinant (MIgG2a)	Mouse	HEK293 Cells
	SIRPα is a type I transmembrane glycoprotein.It contains two Ig-like C1-type domains and one Ig-like V-type domain. Mouse SIRP alpha ECD shares 61%, 75%, 62%, 61%, and 59% aa sequence identity with human, rat, equine, bo...
TMPY-02963	Calcineurin A/PPP3CA Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	PPP3CA, also known as protein phosphatase 2B, is a member of the PPP phosphatase family, PP-2B subfamily. It is the alpha catalytic subunit of protein phosphatase 2B (PP2B). PP2B is a holoenzyme that is comprised of a ca...
TMPY-02964	Calcineurin B/PPP3R1 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	PPP3R1 belongs to the calcineurin regulatory subunit family. It is a regulatory subunit of calcineurin. Calcineurin is composed of two subunits: calcineurin A (CnA) and calcineurin B (CnB). Dephosphorylation of the nucle...
TMPH-01280	EGLN1 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of th...
TMPJ-00271	SMAD3 Protein, Human, Recombinant (His & Flag)	Human	E. coli
	Mothers against decapentaplegic homolog 3(SMAD3) is a cytoplasm protein which belongs to the dwarfin/SMAD family. Smad proteins undergo rapid nuclear translocation upon stimulation by transforming growth factor and in so...
TMPY-02120	XPNPEP2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Aminopeptidase P (APP) is a hydrolase specific for N-terminal imido bonds, which are common to several collagen degradation products, neuropeptides, vasoactive peptides, and cytokines. A membrane-bound and soluble form o...
TMPY-04421	FES Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	Proto-oncogene tyrosine-protein kinase Fes/Fps, also known as Proto-oncogene c-Fes, Proto-oncogene c-Fps, Feline sarcoma oncogene, FES and FPS, is a protein which contains oneFCH domain, oneprotein kinase domain and o...
TMPH-02186	TERT Protein, Human, Recombinant (His)	Human	E. coli
	Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic c...
TMPY-03435	NCKIPSD Protein, Human, Recombinant (GST)	Human	E. coli
	NCKIPSD is localized exclusively in the cell nucleus. It plays a role in signal transduction and may function in the maintenance of sarcomeres and the assembly of myofibrils into sarcomeres. NCKIPSD also plays an importa...
TMPH-01246	POLR3A Protein, Human, Recombinant (His)	Human	E. coli
	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs,...
TMPJ-00936	CCND2 Protein, Human, Recombinant (His)	Human	E. coli
	CCND2，also known as G1/S-specific cyclin-D2，is a member of the highly conserved cyclin family. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each ...
TMPH-01535	INSIG2 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR. Acts as a negative regulator of cholesterol...
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