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ターゲット

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T10463L	Bax inhibitor peptide V5 acetate	Bax inhibitor peptide V5 acetate（579492-81-2 free base)	Apoptosis
	Bax inhibitor peptide V5 acetate (Bax inhibitor peptide V5 acetate（579492-81-2 free base)) is a Bax-mediated apoptosis inhibitor, used for cancer treatment.		Apoptosis
T10463	Bax inhibitor peptide V5	BIP-V5,BAX Inhibiting Peptide V5	BCL
	Bax inhibitor peptide V5 (BIP-V5) is a Bax-mediated apoptosis inhibitor with anticancer activity.		BCL
T40379	Bax BH3 peptide (55-74), wild type	Bax BH3 peptide (55-74), wild type
	Bax BH3 peptide (55-74), wild type is a 20-amino acid peptide (Bax 1) known for its ability to induce apoptosis in various cell line models.
T14499	Bax activator-1		BCL
	Bax activator-1 (compound 106) is a Bax activator. It induces Bax-dependent tumor cell apoptosis[1].		BCL
T8649	TMBIM6 antagonist-1	BAX-inhibitor-1,BIA	mTOR
	TMBIM6 antagonist-1 (BAX-inhibitor-1) is a bax inhibitor		mTOR
TP2203	Bax inhibitor peptide, negative control		Others
	The compound is a negative control peptide for the Bax inhibitor peptides V5 and P5.		Others
T82918	BAX-IN-1
	BAX-IN-1 is a potential selective inhibitor of Bcl-2-associated X protein (BAX).
T26737	Bamifylline Hydrochloride	BAX-2793Z,AC 3810,AC-3810,BAX2793Z,BAX 2793Z
	Bamifylline Hydrochloride, an adenosine A1 receptor antagonist, is uesd to treat bronchiectasis and chronic obstructive pulmonary disease.
T7538	Tetraethylammonium chloride		Potassium Channel
	Tetraethylammonium chloride is a quaternary ammonium compound. It is a non-selective potassium channel blocker. It is a good substrate for organic cation transporter proteins and has antitumor properties.		Potassium Channel
T5210	BAI1		Apoptosis , BCL
	BAI1 (Bax channel blocker) is a potent inhibitor of Bax-mediated mitochondrial cytochrome C release (IC50: 0.52 μM).		Apoptosis , BCL
T5104	BTSA1		Apoptosis , BCL
	BTSA1 is a BAX activator that binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis.		Apoptosis , BCL
T15771	Lobaplatin	D-19466	DNA Alkylation
	Lobaplatin (D-19466) (D-19466) is a diastereometric mixture of platinum(II) complexe. Lobaplatin (D-19466) is a third-generation platinum anti-neoplastic agent which shows activity for a variety of tumour types and is a ...		DNA Alkylation
T2099	ABT-737		Mitophagy , BCL , Autophagy
	ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w (EC50s: 78.7/30.3/197.8 nM).		Mitophagy , BCL , Autophagy
T12412L	PDK4-IN-1 hydrochloride		Apoptosis , PDK
			Apoptosis , PDK
T8978	DD1	3,3'-Diamino-4'-methoxyflavone,HUN85111	Proteasome
	DD1 (HUN85111) is a proteasome inhibitor that induces human myeloid tumor-selective apoptosis.		Proteasome
T4215	TCS-PIM-1-4a	SMI-4a	Apoptosis , Pim
	TCS-PIM-1-4a (SMI-4a), a Pim inhibitor, blocks mTORC1 activity through activation of AMPK and kills a wide range of both myeloid and lymphoid cell lines (IC50=0.8-40 μM).		Apoptosis , Pim
T23861	CAY10526	CAY-10526,BTH,CAY 10526	Prostaglandin Receptor
	CAY10526 (BTH) is a selective mPGES-1 inhibitor that acts as an inhibitor of the NF-κB signaling pathway.		Prostaglandin Receptor
T0942	Quinacrine dihydrochloride	Mepacrine dihydrochloride,SN-390,Quinacrine 2HCl	Apoptosis , Mitophagy , DNA , Phospholipase , Parasite , Autophagy , Histamine Receptor
	Quinacrine dihydrochloride (Mepacrine dihydrochloride) is the dihydrochloride salt of the 9-aminoacridine derivative quinacrine with potential antineoplastic and antiparasitic activities.
T6583	MG-101	ALLN,Ac-LLnL-CHO,Calpain inhibitor I,Calpain inhibitor-1,MG101	Cysteine Protease , Proteasome
	MG-101 (Calpain inhibitor I) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins.		Cysteine Protease , Proteasome
T15212	Emamectin Benzoate	MK-244	Apoptosis , Reactive Oxygen Species , GABA Receptor , Parasite
	Emamectin Benzoate (MK-244), by binding gamma-aminobutyric acid (GABA) receptor and glutamate-gated chloride channels disrupting nerve signals within arthropods, acts as a chloride channel activator.
T61373	Baxdrostat		Others
	Baxdrostat is an aldosterone synthase inhibitor.		Others
T31668	Eribaxaban	PD 348292,PD0348292,PD-0348292,PD-348292,PD 0348292,PD348292	Factor Xa
	Eribaxaban (PD348292) is an orally available factor Xa inhibitor for the prevention and treatment of venous thromboembolism.		Factor Xa
T76822	Pagibaximab
	Pagibaximab, a chimeric IgG1 antibody, targets the lipoteichoic acid on the surfaces of S. aureus and S. epidermidis, and is utilized for the prevention of staphylococcal sepsis [1].
T68632	Pibaxizine
	Pibaxizine is diphenylmethyl piperazine derivatives. It is a histamine H1 receptor antagonist.
T61372	(S)-Baxdrostat
	(S)-Baxdrostat is an S-enantiomer of Baxdrostat, which functions as an inhibitor of aldosterone synthase [1].
T2453	BAM7		BCL
	BAM 7 is a direct and specific activator of proapoptotic Bax (EC50: 3.3 μM).		BCL
T83636L	NSC 122393	3,4,5,6-Tetrabromofluorescein
	NSC 122393 is a fluorescent dye that inhibits the interaction between Bax and Bcl-X and induces apoptosis in Bcl-X overexpressing breast cancer cells.
T6881	LTX-315	LTX315,Oncopore,K-K-W-W-K-K-W-Dip-K-NH2	BCL
	LTX-315 (Oncopore), the oncolytic peptide, inhibits cancer cells through Bax/Bak-regulated mitochondrial membrane permeabilization.		BCL
T14846	Bz 423	BZ48	Apoptosis , BCL
	Bz 423 is a potent immunomodulator that induces apoptosis by activating Bax and Bak to induce mitochondrial outer membrane permeabilization and cytochrome c release.Bz 423 shows partial activity in a mouse model of lupus...		Apoptosis , BCL
T61046	Anticancer agent 43		Apoptosis
	Anticancer agent 43 is a potent anticancer agent that induces apoptosis through caspase 3, PARP1, and Bax protein-dependent pathways.Anticancer agent 43 induces DNA damage and can be used in the study of glioblastoma in ...		Apoptosis
T22094	JGB1741	ILS-JGB-1741	Sirtuin
	JGB1741 (ILS-JGB-1741) is a potent and selective inhibitor of SIRT1 with an IC50 of 15 μM. JGB1741 modulates Bax/Bcl2 ratio, cytochrome c release and PARP cleavage and increases the acetylated p53 levels leading to p53-m...		Sirtuin
T37518	Diphenyl disulfide	Phenyl disulfide	Apoptosis , BCL , Endogenous Metabolite
	Diphenyl disulfide (Phenyl disulfide) shows anticancer activity in breast cancer cell lines.Diphenyl disulfide induces and enhances apoptosis in breast cancer cells through Bax protein hydrolysis activation and concomita...		Apoptosis , BCL , Endogenous Metabolite
T6641	Rilmenidine Phosphate		Apoptosis , Adrenergic Receptor , Autophagy , Imidazoline Receptor
	Rilmenidine Phosphate is a selective I(1) imidazoline receptor agonist, used to treat hypertension.
T24806	SMBA2	SMBA-2,NSC4436,NSC 4436,NSC-4436,SMBA 2
	SMBA2 is a Bax activator. It acts by specifically targeting the binding pocket at S184.
T23925	CYD-2-11	CYD 2 11,CYD211
	CYD-2-11 is an effective and selective Bax agonist. It acts by targeting the structural pocket proximal to S184 in the C-terminal region of Bax.
T60997	GL0388
	GL0388 is a Bax activator and leads to Bax insertion into mitochondrial membrane that induce Bax-mediated apoptosis. GL0388 inhibits tumor growth of breast cancer xenograft in vivo which also exhibits antiproliferative a...
T8792	SMBA1
	SMBA1 is a Bax activator and a potent Bax agonist (Ki : 43.3 nM) that induces cell cycle arrest and apoptosis in malignant glioma cells.SMBA1 has shown antitumor activity by enhancing Bax expression.SMBA1 can be used in ...
T16155	MSN-125		Akt
	MSN-125 effectively inhibits Bax/Bak-mediated apoptosis in HCT-116, BMK Cells, and primary cortical neurons protect primary neurons against glutamate excitotoxicity. MSN-125 is an effective Bax and Bak oligomerization in...		Akt
T28117	MSN-50	MSN50,MSN 50
	MSN-50, an inhibitor of Bax and Bak oligomerization, inhibits liposome permeabilization, prevents genotoxic cell death and promotes neuroprotection.
T63530	Apoptotic agent-3
	Apoptotic agent-3 utilizes a potential mitochondrial-mediated Bcl-2/Bax pathway and activates the caspase-3 pathway to promote apoptosis, exhibiting anti-proliferative effects that can be used to study cancer.
T28411	Physapubenolide	NSC 368674,NSC368674,NSC-368674
	Physapubenolide is natural cytotoxic withanolide antitumor agent. Physapubenolide induces apoptosis by decreasing mitochondrial membrane potential and elevating the Bax/Bcl-2 protein expression ratio.
T76033	Humanin
	Humanin, a 24-amino acid anti-apoptotic peptide and Bax inhibitor, prevents Bax translocation from the cytosol to mitochondria and obstructs its activation. This mitochondria-associated peptide has neuroprotective proper...
T63188	Apoptotic agent-2
	Apoptotic agent-2 is capable of downregulating Bcl-2 and upregulating Bax and caspase-3 to induce apoptosis, exhibiting anti-proliferative effects that can be used in cancer research.
T72570	Antitumor agent-83
	Antitumor agent-83 acts as a BAX pro-apoptotic protein activator, significantly inhibiting tumor cell proliferation and mediating cell apoptosis through BAX's conformational activation. It also impedes the A549 cell cycl...
T62814	Antitumor agent-77
	Antitumor agent-77 inhibits the growth and migration of cancer cells and has anticancer effects. antitumor agent-77 inhibits GPx-4 and enhances COX2-induced iron sagging. antitumor agent-77 activates the intrinsic apopto...
T62044	Anticancer agent 71
	Anticancer agent 71 (Compound 4b) is a potent anticancer agent. Anticancer agent 71 arrests cell cycle at G2/M phase. Anticancer agent 71 induces apoptosis through upregulating Bax, Ikb-α and cleaved PARP and downregulat...
T76073	BH3 hydrochloride
	BH3 hydrochloride, a peptide that crosses the blood-brain barrier, induces apoptosis either through direct activation of the pro-apoptotic proteins Bax/Bak or by inhibiting anti-apoptotic Bcl-2 proteins (Bcl-2, Bcl-XL, B...
T30807	CG0009	CG-0009,CG 0009
	CG0009 is a potent and highly selective glycogen synthase kinase 3 (GSK3) inhibitor that inhibitions proliferation, induces apoptosis, and activates the p53-Bax pathway in breast cancer cells through cyclin D1 depletion....
T21911	Rilmenidine hemifumarate	Rilmenidine (hemifumarate),S-3341 hemifumarate	Apoptosis , Imidazoline Receptor
	Rilmenidine hemifumarate (S-3341 hemifumarate) is a novel, orally active and selective I1 imidazoline receptor and α2-adrenoceptor agonist that induces autophagy, regulates the proliferation of leukaemia cells, stimulate...		Apoptosis , Imidazoline Receptor
T79242	Mcl-1 inhibitor 16
	Mcl-1 Inhibitor 16 (Compound 9), a platinum-based mitochondrial-targeting agent, inhibits Mcl-1 and induces Bax/Bak-dependent apoptosis in cancer cells. This compound exhibits antitumor activity and may be utilized as a ...

Compounds

Bax inhibitor peptide V5 acetate

T10463L

Synonym: Bax inhibitor peptide V5 acetate（579492-81-2 free base)

Target: Apoptosis

Bax inhibitor peptide V5

T10463

Synonym: BIP-V5,BAX Inhibiting Peptide V5

Target: BCL

Bax BH3 peptide (55-74), wild type

T40379

Synonym: Bax BH3 peptide (55-74), wild type

Synonym: BAX-inhibitor-1,BIA

Target: mTOR

Bax inhibitor peptide, negative control

Bamifylline Hydrochloride

T26737

Synonym: BAX-2793Z,AC 3810,AC-3810,BAX2793Z,BAX 2793Z

Target:

Tetraethylammonium chloride

T7538

Synonym:

Target: Potassium Channel

BAI1

T5210

Synonym:

Target: Apoptosis, BCL

BTSA1

T5104

Synonym:

Target: Apoptosis, BCL

Lobaplatin

T15771

Synonym: D-19466

Target: DNA Alkylation

ABT-737

T2099

Synonym:

Target: Mitophagy, BCL, Autophagy

PDK4-IN-1 hydrochloride

T12412L

Synonym:

Target: Apoptosis, PDK

DD1

T8978

Synonym: 3,3'-Diamino-4'-methoxyflavone,HUN85111

Target: Apoptosis, Pim

CAY10526

T23861

Synonym: CAY-10526,BTH,CAY 10526

Target: Prostaglandin Receptor

Quinacrine dihydrochloride

T0942

Synonym: Mepacrine dihydrochloride,SN-390,Quinacrine 2HCl

Target: Apoptosis, Mitophagy, DNA, Phospholipase, Parasite, Autophagy, Histamine Receptor

MG-101

T6583

Synonym: ALLN,Ac-LLnL-CHO,Calpain inhibitor I,Calpain inhibitor-1,MG101

Target: Cysteine Protease, Proteasome

Emamectin Benzoate

T15212

Synonym: MK-244

Target: Apoptosis, Reactive Oxygen Species, GABA Receptor, Parasite

Synonym: PD 348292,PD0348292,PD-0348292,PD-348292,PD 0348292,PD348292

Synonym: 3,4,5,6-Tetrabromofluorescein

Target:

LTX-315

T6881

Synonym: LTX315,Oncopore,K-K-W-W-K-K-W-Dip-K-NH2

Target: Apoptosis, BCL

Synonym: ILS-JGB-1741

Target: Sirtuin

Diphenyl disulfide

T37518

Synonym: Phenyl disulfide

Target: Apoptosis, BCL, Endogenous Metabolite

Rilmenidine Phosphate

T6641

Synonym:

Target: Apoptosis, Adrenergic Receptor, Autophagy, Imidazoline Receptor

SMBA2

T24806

Synonym: SMBA-2,NSC4436,NSC 4436,NSC-4436,SMBA 2

Target:

CYD-2-11

T23925

Synonym: CYD 2 11,CYD211

Synonym: MSN50,MSN 50

Synonym: NSC 368674,NSC368674,NSC-368674

Synonym: CG-0009,CG 0009

Target:

Rilmenidine hemifumarate

T21911

Synonym: Rilmenidine (hemifumarate),S-3341 hemifumarate

Target: Apoptosis, Imidazoline Receptor

カタログ番号	製品名	別名	ターゲット
T2S0500	Ilexsaponin A	Ilexsaponin A1	Others
	1. Ilexsaponin A (Ilexsaponin A1) shows protective effects on ischemia-reperfusion-induced myocardial injury through anti-apoptotic pathway.		Others
TN1195	17-Hydroxy sprengerinin C	17-羟基 SPRENGERININ C	BCL , Others , Caspase
	17-Hydroxy sprengerinin C is a glycoside compound isolated from rhizomes of Polygonatum sibiricum with stronger anticancer activities. 17-Hydroxy sprengerinin C reduces the expression of Blc-2 and pro-caspase3 and increa...		BCL , Others , Caspase
T3322	Trans-Chalcone	Chalcone,Cinnamophenone,Chalkone	Apoptosis , Others , Antifungal , Fatty Acid Synthase
	trans-Chalcone (Chalkone) is an aromatic ketone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones.		Apoptosis , Others , Antifungal , Fatty Acid Synthase
T2764	(S)-10-Hydroxycamptothecin	10-Hydroxycamptothecin,10-HCPT	Apoptosis , Topoisomerase
	(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.		Apoptosis , Topoisomerase
T1079	Metronidazole	Flagyl,Metronidazol,Anagiardil	Apoptosis , NADPH , Hydrogenase , Antibacterial , Antibiotic , Parasite , Antifection
	Metronidazole (Metronidazol) is a synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities.
TN1349	9-Hydroxycalabaxanthone		Antifection
	9-Hydroxycalabaxanthone exhibits cytotoxicity against the HT-29 cell line with ED50 values of 9.1 microM. The combination of 9-hydroxycalabaxanthone with α±-mangostin shows the synergistic antimalarial interaction in bot...		Antifection
T9503	PHYTOSPHINGOSINE		Apoptosis
	Phytosphingosine is a phospholipid with anticancer properties. In cancer cells, Phytosphingosine induces cell apoptosis through activation of caspase 8 and translocation of Bax.		Apoptosis
T3902	Atractylenolide III	ICodonolactone,8β-Hydroxyasterolide	Apoptosis
	Atractylenolide III (ICodonolactone) may have therapeutic potential in treating homocysteine-mediated cognitive impairment and neuronal injury. Atractylenolide III is a potential candidate for the treatment of human lung...		Apoptosis
T5715	(E)-Flavokawain A	FLAVOKAVAIN A(P)	Apoptosis , P450
	(E)-Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice.		Apoptosis , P450
T6S1529	Cynarin	Cyclohexanecarboxylic acid, 1,3-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-4,5-dihydroxy-, (1R,3R,4S,5R)-,Cynarine,1,5-Dicaffeoylquinic acid	Antioxidant , Antiviral , Influenza Virus , Reactive Oxygen Species
	Cynarin (1,5-Dicaffeoylquinic acid) has neuroprotective, and antioxidant effects, it can inhibition of GSK3β as well as the modulation of Bcl-2/Bax.
T5S2083	Puerarin 6''-O-Xyloside		Apoptosis , Caspase
	Puerarin 6''-O-xyloside possesses significant anti-osteoporotic activity on ovariectomy mice, it has significant antitumour activities, the mechanisms are related to increased levels of caspase-3, caspase-7, caspase-9 an...		Apoptosis , Caspase
T13818	Phytohemagglutinin	PHA-M	Apoptosis
	Phytohemagglutinin (PHA-M) is a lectin, isolated from the red kidney bean , induces apoptosis via increasing proapoptotic protein Bax and activating caspases-3. Anti-tumor activity		Apoptosis
TN1393	(-)-Anonaine		Apoptosis , Antioxidant , Parasite , Antifungal
	(-)-Anonaine can be extracted from several species of Magnoliaceae and Annelidae and has antimalarial, antibacterial, antifungal, antioxidant, anticancer, antidepressant and vasodilatory activities. (-)-Anonaine induces ...		Apoptosis , Antioxidant , Parasite , Antifungal
T7027	EURYCOMANONE	Pasakbumin A	Others
	Eurycomanone (Pasakbumin A) is cytotoxic on HepG2 cells by inducing apoptosis through the up-regulation of p53 and Bax, and down-regulation of Bcl-2.Eurycomanone has anti-cancer activity, inhibits A549 lung cancer cell p...		Others
T5S2358	Dehydrocorydaline	Dehydrocorydalin,13-Methylpalmatine	BCL , PARP , p38 MAPK , Caspase , Parasite , Autophagy
	1. Dehydrocorydaline (13-Methylpalmatine) exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSC-LC cells. 2. Dehydrocorydaline stimulates p38 MAPK activation, which can enhance heterodimeriz...		BCL , PARP , p38 MAPK , Caspase , Parasite , Autophagy
T5679	(E)-Ferulic acid	trans-Ferulic acid,(E)-Coniferic acid	BCL , Ferroptosis , Wnt/beta-catenin , Endogenous Metabolite
	(E)-Ferulic acid ((E)-Coniferic acid) causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pr...
T2795	Amygdalin	Laetrile	Others
	Amygdalin (Laetrile) has antifibrotic, antitumor, anti-inflammatory and analgesic effects, amygdalin joint HSYA could inhibit the degeneration of the endplate chondrocytes derived from intervertebral discs of rats induce...		Others
T2909	Fraxetin	7,8-dihydroxy-6-methoxy coumarin	Apoptosis , Others
	Fraxetin (7,8-dihydroxy-6-methoxy coumarin) has dual-antioxidative ,hepatoprotective and antihyperglycemic functions, it shows potent protective effects against CCl4 induced oxidative stress and hepatic fibrosis, has a m...		Apoptosis , Others
TN2103	PROCYANIDIN C1		Apoptosis
	Procyanidin C1 is a natural product, with anti-inflammatory effects, and induces apoptosis.		Apoptosis
T6S1653	Albiflorin	Alibiflorin	Reactive Oxygen Species
	1. Albiflorin (Alibiflorin) has anticonvulsant effect for pain relief. 2. Albiflorin and paeoniflorin has neuroprotective action against Glu toxicity. 3. Albiflorin and paeoniflorin significantly ameliorated Glu-induced ...		Reactive Oxygen Species
T2860	Vanillyl Alcohol	4-Hydroxy-3-methoxybenzenemethanol,3-Methoxy-4-hydroxybenzyl alcohol,4-Hydroxy-3-methoxybenzyl alcohol,Vanillin alcohol,Vanillic alcohol	Apoptosis , Others
	Vanillyl Alcohol (3-Methoxy-4-hydroxybenzyl alcohol) possesses anti-angiogenic, anticonvulsive, anti-inflammatory, anti-oxidant, neuroprotective, and anti-nociceptive activities. Vanillyl alcohol can effectively inhibit ...		Apoptosis , Others
T3864	Erianin		BCL , Antibacterial
	Erianin is a nature product extracted from Dendrobium chrysotoxum, has notable antitumour activity , can cause extensive tumour necrosis, growth delay. Erianin has antiangiogenic action by inhibiting endothelial metaboli...		BCL , Antibacterial
T3895	Polyphyllin I		Apoptosis , Akt , JNK , PDK , mTOR , Autophagy
	Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C, and cleaved-caspase-3 levels. Polyphyllin D ha...		Apoptosis , Akt , JNK , PDK , mTOR , Autophagy
T6917	Oleuropein		Apoptosis , Aromatase , ROS , PPAR
	Oleuropein is an antioxidant polyphenol isolated from olive leaf.		Apoptosis , Aromatase , ROS , PPAR
T10990	Dehydrocorydaline chloride	13-Methylpalmatine chloride	BCL , PARP , p38 MAPK , Caspase , Parasite , Autophagy
	Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid with anti-inflammatory and anti-cancer activity. Can improve the activation of p38 MAPK.		BCL , PARP , p38 MAPK , Caspase , Parasite , Autophagy
T3S2344	β,β-Dimethylacrylshikonin	Dimethylacrylshikonin,β, β-Dimethylacrylshikonin	ERK , HIF/HIF Prolyl-Hydroxylase
	1. β,β-Dimethylacrylshikonin (Dimethylacrylshikonin) is a promising agent for developing an improved strategy for radiotherapy against tumors. (a) Injection of Dimethylacrylshikonin combined with IR treatment significant...		ERK , HIF/HIF Prolyl-Hydroxylase
T3729	Ethyl gallate	Nipagallin A,Phyllemblin,gallic acid ethyl ester	MMP , NF-κB , Akt , Antibacterial
	Ethyl gallate (gallic acid ethyl ester) obviously decreases cell proliferation in MDA-MB-231 and MCF-7 cells in a dose- and time-dependent manner, exhibits cytotoxicity in a dose-dependent manner. Ethyl gallate can inhib...		MMP , NF-κB , Akt , Antibacterial
T6S0052	Chelerythrine	Toddalin,Broussonpapyrine,Cheleritrine	Apoptosis , BCL , PKC , Autophagy
	1. Chelerythrine (Broussonpapyrine) may have antimanic effect . 2. Chelerythrine can inhibit telomerase activity. 3. Chelerythrine is a well-known protein kinase C inhibitor . 4. Chelerythrine has potential antiprolifera...		Apoptosis , BCL , PKC , Autophagy
T2698	Asperosaponin VI	Akebia saponin D,Asperosaponin Ⅵ	Apoptosis , Others , Caspase
	Asperosaponin VI (Akebia saponin D) , the most abundant constituent of the rhizome of Dipsacus asper, has been used for the treatment of lower back pain, traumatic hematoma and bone fractures.		Apoptosis , Others , Caspase
T2S2362	Dehydrocorydaline nitrate		BCL , Others , PARP , p38 MAPK , Caspase , Parasite , Autophagy
	1. Dehydrocorydaline(DHC) not only inhibits antibody-mediated allergic reactions but also influences cell-mediated allergic reactions, and the inhibitory effect of Corydalis Tuber on allergic reactions may be partially a...
T5S0661	Koumine		Others
	1. Koumine can treat the diabetic neuropathy. 2. Koumine has antineoplastic effect, may be a future breast cancer chemotherapeutic agent. 3. Koumine has a significant analgesic effect in rodent behavioral models of infla...		Others
T3824	Jaceosidin		Apoptosis , BCL , COX , UGT
	Jaceosidin has anti-oxidative activity. Jaceosidin has anti-inflammatory activity, also a microglial inhibitor with anti-neuroinflammation activity. aceosidin has anticancer activity, modulates the ERK/ATM/Chk1/2 pathway...		Apoptosis , BCL , COX , UGT
T3S0737	Flavokawain A	Flavokavain A	Apoptosis , p38 MAPK
	NSC-37445 has anti-tumor activity, such as inhibits growth of bladder tumor cells in a nude mice model , prevents the recurrence and progression of non-muscle-invasive urothelial cell carcinoma. NSC-37445 can significant...		Apoptosis , p38 MAPK
TN6394	Alisol B acetate
	Alisol B acetate can induce Bax nuclear translocation and apoptosis in human hormone-resistant prostate cancer PC-3 cells, the Bax activation and translocation from the cytosol to nucleus might be a crucial response to t...
T40940	7,3′,5′-Trihydroxyflavanone
	7,3′,5′-Trihydroxyflavanone, a flavanoid derivative, promotes apoptotic cell death in MCF-7 cells by augmenting Bax expression. Additionally, this compound demonstrates antioxidant properties.
TN1093	Ginsenoside F4		MMP , IL Receptor , BCL
	Ginsenoside F4 has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis, the mechanism is related to the mitochondrial dysfunction and the increase of Bax expression and decrease of Bcl-2 expression.		MMP , IL Receptor , BCL
TN1139	Dehydrocavidine	Dehydrocorydaline	BCL , PARP
	Dehydrocavidine (Dehydrocorydaline) has antitumor activity, it inhibits MCF-7 cell proliferation by inducing apoptosis mediated by regulating Bax/Bcl-2, activating caspases as well as cleaving PARP.		BCL , PARP
TMA1743	Ergosterol peroxide		ERK , VEGFR , p38 MAPK , Wnt/beta-catenin , Akt , JAK , CDK , JNK , STAT , Antifection
	Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Foxo3a activity by inhibiting pAKT and c-Myc and activating pr...
TN3653	Cimidahurinine		BCL , ROS
	Cimidahurinine can attenuate Doxorubicin (DOX)-induced cardiotoxicity in a dose-dependent manner with EC50 values of 45.79 uM; it protects against cardiotoxicity by decreasing reactive oxygen species (ROS) accumulation a...		BCL , ROS
TN2308	Wilfortrine		BCL
	Wilfortrine can induce liver cancer cell HepG2 apoptosis, but with no effect on the cell cycle, mainly by promoting Bax expression and inhibiting anti-apoptotic protein Bcl-2 expression.		BCL
TN6419	Chamaejasmine
	Chamaejasmine could be a candidate drug for osteosarcoma and breast cancer chemoprevention, induces apoptosis in MG63 and HEp-2 cells by Akt inactivation and dephosphorylation of BAD. It inhibits Bcl-2 expression and ind...
T75485	Dehydrobruceine B
	Dehydrobruceine B, a quassinoid isolated from Brucea javanica, demonstrates a synergistic effect with Cisplatin in inducing apoptosis through the mitochondrial pathway. It enhances the expression of apoptosis-inducing fa...
T73403	Aviculin
	Aviculin, a lignan glycoside, exhibits significant anticancer properties, particularly in inhibiting the metabolic activity of MCF-7 cells to below 50%, with an IC 50 value of 75.47 μM. It promotes apoptosis in breast ca...
TN5201	Uncarinic acid E		BCL , MEK , Caspase , PI3K , Antifection , p53
	Uncarinic acid E has anti-cancer activity, it induces apoptosis in HepG2 cells via accumulation of p53, alters the Bax/Bcl-2 ratio, and activates caspases, resulting in cytochrome c release from the mitochondria. A mixtu...		BCL , MEK , Caspase , PI3K , Antifection , p53
TN2257	Tanshinone IIB		BCL , Caspase , P-gp
	Co-treatment with Tanshinone IIB (TSB) significantly inhibits the DNA laddering, cytotoxicity and apoptosis of rat cortical neurons induced by staurosporine in a concentration-dependent manner; TSB also suppresses the el...		BCL , Caspase , P-gp
T66078	Cardamonin
	Cardamonin, a chalcone extracted from cardamom spice with anti-inflammatory and anti-tumor activities. Cardamonin decreased viability of NPC(Nasopharyngeal carcinoma ) cells in a concentration-dependent manner. The IC50 ...
TN4999	Serratenediol		BCL , PARP , Caspase
	Serratenediol demonstrates strong inhibitory effects on the Epstein-Barr virus early antigen (EBV-EA) activation without showing any cytotoxicity, its effects being stronger than that of a representative control, oleanol...		BCL , PARP , Caspase
TN1094	Ginsenoside Rg6		Apoptosis , NF-κB
	Ginsenoside Rg6 can inhibit JK cell proliferation in human lymphocytoma and induce its apoptosis, the mechanism may through mitochondrial dysfunction and an increase of Bax expression and decrease of Bcl-2 expression.		Apoptosis , NF-κB

天然物製品

Ilexsaponin A

T2S0500

Synonym: Ilexsaponin A1

Target: Others

17-Hydroxy sprengerinin C

TN1195

Synonym: 17-羟基 SPRENGERININ C

Target: BCL, Others, Caspase

trans-Chalcone

T3322

Synonym: Chalcone,Cinnamophenone,Chalkone

Target: Apoptosis, Others, Antifungal, Fatty Acid Synthase

(S)-10-Hydroxycamptothecin

T2764

Synonym: 10-Hydroxycamptothecin,10-HCPT

Target: Apoptosis, Topoisomerase

Metronidazole

T1079

Synonym: Flagyl,Metronidazol,Anagiardil

Target: Apoptosis, NADPH, Hydrogenase, Antibacterial, Antibiotic, Parasite, Antifection

9-Hydroxycalabaxanthone

Synonym: ICodonolactone,8β-Hydroxyasterolide

Target: Apoptosis

(E)-Flavokawain A

T5715

Synonym: FLAVOKAVAIN A(P)

Target: Apoptosis, P450

Cynarin

T6S1529

Synonym: Cyclohexanecarboxylic acid, 1,3-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-4,5-dihydroxy-, (1R,3R,4S,5R)-,Cynarine,1,5-Dicaffeoylquinic acid

Target: Antioxidant, Antiviral, Influenza Virus, Reactive Oxygen Species

Puerarin 6''-O-Xyloside

T5S2083

Synonym:

Target: Apoptosis, Caspase

Target: Apoptosis, Antioxidant, Parasite, Antifungal

EURYCOMANONE

T7027

Synonym: Pasakbumin A

Target: Others

Dehydrocorydaline

T5S2358

Synonym: Dehydrocorydalin,13-Methylpalmatine

Target: BCL, PARP, p38 MAPK, Caspase, Parasite, Autophagy

(E)-Ferulic acid

T5679

Synonym: trans-Ferulic acid,(E)-Coniferic acid

Target: BCL, Ferroptosis, Wnt/beta-catenin, Endogenous Metabolite

Synonym: 7,8-dihydroxy-6-methoxy coumarin

Target: Apoptosis, Others

Target: Reactive Oxygen Species

Vanillyl Alcohol

T2860

Synonym: 4-Hydroxy-3-methoxybenzenemethanol,3-Methoxy-4-hydroxybenzyl alcohol,4-Hydroxy-3-methoxybenzyl alcohol,Vanillin alcohol,Vanillic alcohol

Target: Apoptosis, Others

Erianin

T3864

Synonym:

Target: BCL, Antibacterial

Polyphyllin I

T3895

Synonym:

Target: Apoptosis, Akt, JNK, PDK, mTOR, Autophagy

Oleuropein

T6917

Synonym:

Target: Apoptosis, Aromatase, ROS, PPAR

Dehydrocorydaline chloride

T10990

Synonym: 13-Methylpalmatine chloride

Target: BCL, PARP, p38 MAPK, Caspase, Parasite, Autophagy

β,β-Dimethylacrylshikonin

T3S2344

Synonym: Dimethylacrylshikonin,β, β-Dimethylacrylshikonin

Target: ERK, HIF/HIF Prolyl-Hydroxylase

Ethyl gallate

T3729

Synonym: Nipagallin A,Phyllemblin,gallic acid ethyl ester

Target: MMP, NF-κB, Akt, Antibacterial

Chelerythrine

T6S0052

Synonym: Toddalin,Broussonpapyrine,Cheleritrine

Target: Apoptosis, BCL, PKC, Autophagy

Asperosaponin VI

T2698

Synonym: Akebia saponin D,Asperosaponin Ⅵ

Target: Apoptosis, Others, Caspase

Dehydrocorydaline nitrate

T2S2362

Synonym:

Target: BCL, Others, PARP, p38 MAPK, Caspase, Parasite, Autophagy

Target: Apoptosis, BCL, COX, UGT

Flavokawain A

T3S0737

Synonym: Flavokavain A

Target: Apoptosis, p38 MAPK

7,3′,5′-Trihydroxyflavanone

Target: MMP, IL Receptor, BCL

Dehydrocavidine

TN1139

Synonym: Dehydrocorydaline

Target: ERK, VEGFR, p38 MAPK, Wnt/beta-catenin, Akt, JAK, CDK, JNK, STAT, Antifection

Target: BCL, MEK, Caspase, PI3K, Antifection, p53

Tanshinone IIB

TN2257

Synonym:

Target: BCL, Caspase, P-gp

Target: BCL, PARP, Caspase

Ginsenoside Rg6

TN1094

Synonym:

Target: Apoptosis, NF-κB

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPH-01502	Humanin Protein, Human, Recombinant (GST)	Human	E. coli
	Plays a role as a neuroprotective factor. Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease. Mediates its neuroprotective e...
TMPH-01503	Humanin Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Plays a role as a neuroprotective factor. Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease. Mediates its neuroprotective e...
TMPK-00636	BID Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Bid, BH3-interacting domain death agonist, was initially cloned based in its ability to interact with both Bcl-2 and Bax. Bid contains only the BH3 domain, which is required for its interaction with the Bcl-2 family prot...
TMPJ-00584	Bc1-w Protein, Human, Recombinant (His)	Human	E. coli
	Bcl-2-like protein 2 (BCL2L2) belongs to the Bcl-2 family. BCL2L2 is highly expressed in thebrain, spinal cord, testis, pancreas, heart, spleen, and mammary glands. BCL2L2 is a peripheral membrane protein containing thre...
TMPH-02538	Beclin-1 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways...
TMPY-02122	IFNGR2 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Interferon-gamma receptor beta chain (IFNgammaR2), also known as IFNGR2, belongs to the type II cytokine receptor family, whose deficiency is a cause of autosomal recessive mendelian susceptibility to mycobacterial disea...
TMPH-02521	PYCARD Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner. Involved in activation of the mit...
TMPH-02574	P53 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negativel...
TMPH-01664	OMA1 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Activated in response to various mitochondrial stress, leading to the proteolytic cleavage of target proteins, such as OPA...
TMPH-03264	P53 Protein, Rat, Recombinant (His)	Rat	E. coli
	Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negativel...