|
T6991 |
Nitroprusside disodium dihydrate
|
Sodium Nitroferricyanide(III) Dihydrate,Sodium Nitroprusside Dihydrate |
Guanylate cyclase
,
Autophagy
|
|
Nitroprusside disodium dihydrate (Sodium Nitroprusside Dihydrate) is a potent vasodilator working through releasing NO spontaneously in blood. |
|
T7617 |
Neurotensin(8-13)
|
Neurotensin(8-13)(3TFA) |
Neurotensin Receptor
|
|
Neurotensin(8-13) is Neurotensin (NT) fragment, Neurotensin(8-13) results in a decrease in cell-surface NT1 receptors (NTR1) density. |
|
T19552 |
RPH-2823
|
|
Others
|
|
RPH-2823, a basic amphotericin analog, is diuretic, natriuretic, and potassium-preserving, inducing a dose-dependent decrease in SCC and an increase in trans-epithelial resistance. |
|
T28882 |
Sultosilic acid, piperazine salt
|
A-585,Mimedran,piperazine-sultosylate,A585,A 585 |
|
|
Sultosilic acid piperazine salt is a drug with lowering lipid activity. It causes significant shortening of the euglobulin lysis time and a significant diminution of platelet adhesiveness, as well as statistically signif... |
|
T15794 |
LUT014
|
|
Raf
|
|
LUT014 is a B-Raf inhibitor (IC50: 11.7 nM) and developed to decrease dose-limiting acneiform lesions associated with EGFR Inhibitors treatment. |
|
T0839 |
Ketoprofen
|
RP-19583 |
Apoptosis
,
COX
,
MRP
|
|
Ketoprofen (RP-19583) is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic effects. Ketoprofen inhibits the activity of the enzymes cyclo-oxygenas... |
|
T1299 |
3-Pyridinemethanol
|
Nicotinyl alcohol,Roniacol |
Others
|
|
3-Pyridinemethanol (Roniacol) is an alcohol analog of NICOTINIC ACID which is a direct-acting peripheral vasodilator that causes flushing and may decrease blood pressure. It is used in vasospasm and threatened GANGRENE. |
|
T7617L |
Neurotensin(8-13) 3TFA(60482-95-3(free base))
|
|
Neurotensin Receptor
|
|
Neurotensin(8-13) 3TFA is Neurotensin (NT) fragment. Neurotensin(8-13) 3TFA results in a decrease in cell-surface NT1 receptors (NTR1) density. |
|
T28543 |
RK-9123016
|
RK9123016,RK 9123016 |
Sirtuin
|
|
RK-9123016 is a SIRT2 inhibitor. RK-9123016 increases the acetylation level of eukaryotic translation initiation factor 5A (eIF5A), a physiological substrate of SIRT2, and reduces cell viability of human breast cancer ce... |
|
T21432 |
Molindone
|
(±)-Molindone,Moban,Molindonum,SPN-810M |
Dopamine Receptor
|
|
Molindone ((±)-Molindone) is a therapeutic antipsychotic used to treat schizophrenia by blocking the action of dopamine in the brain. molindone is often used in combination with serotonin in a dose-dependent manner to in... |
|
T67778 |
DCeMM1
|
|
Molecular Glues
|
|
dCeMM1 is a RBM39 glue degrader. dCeMM1 can re-direct the activity of the CRL4DCAF15 ligase. dCeMM1 can decrease the expression levels of RBM39 in WT KBM7 cells. |
|
T67728 |
α-Glucosidase-IN-23
|
|
Glucosidase
|
|
α-Glucosidase-IN-23 is an orally active α-Glucosidase inhibitor. α-Glucosidase-IN-23 can decrease blood glucose by α-glucosidase inhibition (IC50= 4.48 μM). |
|
T3937 |
Methyl L-histidinate dihydrochloride
|
L-Histidine methyl ester dihydrochloride |
HDAC
|
|
The inhibitory effect of Methyl L-histidinate dihydrochloride (L-Histidine methyl ester dihydrochloride) on histidine decarboxylase in Sprague-Dawley rat stomach assessed as decrease in 14CO2 production with activty valu... |
|
T3685 |
SR9009
|
Stenabolic,REV-ERB Agonist II |
Autophagy
|
|
SR9009 (Stenabolic), a REV-ERB agonist, increases the constitutive repression of genes regulated by REV-ERBα/ERBβ (IC50: 670/800 nM). Through activation of REV-ERB, SR9009 can decrease circadian locomotor activity during... |
|
T9468 |
FR054
|
|
Others
|
|
FR054 is an inhibitor of the Hexosamine Biosynthetic Pathway (HBP) enzyme PGM3, with a remarkable anti-breast cancer effect. FR054 induces in different breast cancer cells a dramatic decrease in cell proliferation and su... |
|
T1291 |
Cisapride
|
Prepulsid,R 51619,Pridesia,Kaudalit,(±)-Cisaprid,Kinestase |
Potassium Channel
,
5-HT Receptor
,
HER
|
|
Cisapride (R 51619) is a serotonin type 4 (5-HT4) receptor agonists are potent prokinetic agents that act on serotonin receptors in the intestine and promote intestinal peristalsis, increase gastric emptying and decrease... |
|
T67901 |
SRD5A1-IN-1
|
|
Others
|
|
SRD5A1-IN-1 is an inhibitor of steroid 5α-reductase type 1 (SRD5A1, IC50 = 1.44 µM). SRD5A1-IN-1 lowers the production of dihydrotestosterone and shows a significant decrease in the SRD5A1 protein expression. |
|
T2639 |
LY2811376
|
|
Beta Amyloid
,
Beta-Secretase
,
BACE
|
|
LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM). It has 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition... |
|
T0477 |
Zileuton
|
Abbott 64077,A 64077 |
Ferroptosis
,
Lipoxygenase
,
COX
|
|
Zileuton (A 64077) is a synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the formation of leukotrienes from arachidonic acid; ca... |
|
TP2308 |
TB500 acetate(885340-08-9 free base)
|
Frag17-23 Acetate,TB500 Acetate |
Others
|
|
TB500 acetate(885340-08-9 free base) (Frag17-23 Acetate) is a synthetic version of an active region of thymosin β4. It promote endothelial cell differentiation, angiogenesis in dermal tissues, keratinocyte migration, col... |
|
T64923 |
Sodium citrate
|
Citrosodine,Natrocitral |
Others
|
|
Sodium citrate (Natrocitral) is the sodium salt of citric acid.Citric acid trisodium induces apoptosis and cell cycle arrest at G2/M phase and S phase. Sodium citrate cause oxidative damage of the liver by means of the d... |
|
T22678 |
3,5-Bis(4-nitrophenoxy)benzoic acid
|
Compound W |
Gamma-secretase
|
|
3,5-Bis(4-nitrophenoxy)benzoic acid (Compound W) is an inhibitor of γ-secretase. It also causes a decrease in the released levels of Aβ42 and notch-1 Aβ-like peptide 25 (Nβ25). |
|
T1928 |
Anacetrapib
|
MK-0859 |
CETP
|
|
Anacetrapib (MK-0859) (MK0859) is an effective, specific, reversible rhCETP and mutant CETP(C13S) inhibitor (IC50: 7.9 nM and 11.8 nM). Anacetrapib reduces the transfer of cholesteryl ester from HDL to LDL and/or VLDL th... |
|
T27029 |
Cjoc42
|
cjoc 42,cjoc-42 |
|
|
Cjoc42 is an inhibitor of gankyrin, an ankyrin-repeat oncoprotein whose overexpression has been implicated in the development of many cancer types. cjoc42 prevents the decrease in p53 protein levels normally associated w... |
|
T22271 |
BFMO (biogenic Fe-Mn oxides)
|
N,N'-Difurfuryloxamide |
Others
|
|
BFMO (biogenic Fe-Mn oxides) (N,N'-Difurfuryloxamide) could eliminate or decrease Fe(II), Mn(II), and As(III&V) species simultaneously. Moreover, BFMO (biogenic Fe-Mn oxides) can be used for As removal from water contain... |
|
T21526 |
α-Guanidinoglutaric Acid
|
|
Others
|
|
α-Guanidinoglutaric Acid is found in cobalt-induced epileptogenic focus tissue in the cerebral cortex of cats. α-Guanidinoglutaric Acid-induced seizures are associated with abnormal serotonergic function and that they ar... |
|
T3351 |
Onatasertib
|
CC223,CC 223,CC-223 |
Apoptosis
,
c-Fms
,
DNA-PK
,
FLT
,
PI3K
,
mTOR
|
|
Onatasertib (CC223) is an orally available mTOR inhibitor with potential antitumor activity. Onatasertib inhibits the activity of mTOR, which may result in the induction of tumor cell apoptosis and a decrease in tumor ce... |
|
T6381 |
Amifostine trihydrate
|
Ethyol trihydrate,WR2721,Amifostine |
Others
,
HIF/HIF Prolyl-Hydroxylase
|
|
Amifostine trihydrate (WR2721) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin. |
|
T21013 |
Clomipramine
|
Chlorimipramine,Anafranil,Clomicalm,Anafranil (free base),Clomipramina |
5-HT Receptor
|
|
Clomipramine (Clomicalm) is a tricyclic antidepressant (TCA). It is used for the treatment of the panic disorder, obsessive-compulsive disorder, major depressive disorder, and chronic pain. It may decrease the risk of su... |
|
T0030 |
Bupivacaine hydrochloride
|
Vivacaine,Bupivacaine HCl |
Sodium Channel
|
|
Bupivacaine hydrochloride (Vivacaine) is a long-acting, amide-type local anesthetic. Bupivacaine hydrochloride reversibly binds to specific sodium ion channels in the neuronal membrane, resulting in a decrease in the vol... |
|
T1625 |
Lomefloxacin hydrochloride
|
Lomefloxacin HCl,Okacyn,Maxaquin |
Topoisomerase
,
Antibacterial
,
Antibiotic
|
|
Lomefloxacin hydrochloride (Okacyn) inhibits DNA gyrase, a type II topoisomerase involved in the induction or relaxation of supercoiling during DNA replication. This inhibition leads to a decrease in DNA synthesis during... |
|
T39039 |
FSCPX
|
|
Adenosine Receptor
|
|
FSCPX is a potent and selective irreversible antagonist of the A1 adenosine receptor (A1AR), exhibiting low nanomolar binding potency. Additionally, FSCPX can effectively decrease the interstitial adenosine level in the ... |
|
T83971L |
LCC-12 FA
|
|
Antiviral
,
Antibacterial
|
|
LCC-12 FA is a dimer composed of metformin that induces a decrease in the NAD(H) pool by targeting mitochondrial copper(ii).LCC-12 FA reduces inflammation in mouse models of bacterial and viral infections and may be used... |
|
T6695 |
Tasquinimod
|
ABR-215050 |
HDAC
|
|
Tasquinimod (ABR-215050) is a quinoline-3-carboxamide linomide analog with antiangiogenic and potential antineoplastic activities. Tasquinimod has been shown to decrease blood vessel density but the exact mechanism of ac... |
|
T21309 |
Nafarelin acetate(76932-56-4 free base)
|
RS-94991-298,Nafarelin acetate,Nafarelin acetate hydrate,Synarel |
GNRH Receptor
|
|
Nafarelin acetate(76932-56-4 free base) (RS-94991-298) is a GnRH agonist that acts as an analog of GnRH. Nafarelin acetate(76932-56-4 free base) causes a decrease in the pituitary secretion of gonadotropins luteinizing h... |
|
T24816 |
SP-100030
|
SP100030,SP 100030 |
NF-κB
|
|
SP-100030 is a dual inhibitor of NF-κB and activator protein-1 (AP-1), demonstrating potent inhibition with IC50 values of 50 nM for both. It effectively reduces the production of IL-2, IL-8, and TNF-alpha in Jurkat and ... |
|
T7218 |
Endomorphin 2
|
|
Opioid Receptor
|
|
Endomorphins-2 (EM-2) could decrease both the frequency and amplitude of the sEPSC of the motoneurons in lamina IX, which was reversed by the MOR antagonist CTOP. EM-2-IR fibers originated from primary afferent fibers f... |
|
T1496 |
Amiodarone hydrochloride
|
Amiodar,Amiodarone HCl,Nexterone |
Potassium Channel
,
Adrenergic Receptor
,
Autophagy
|
|
Amiodarone hydrochloride (Amiodarone HCl) is an antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM C... |
|
T6301 |
Tosedostat
|
CHR-2797 |
Aminopeptidase
,
AChR
|
|
Tosedostat (CHR-2797) is an orally bioavailable inhibitor of the M1 family of aminopeptidases with potential antineoplastic activity. Tosedostat is converted intracellularly into a poorly membrane-permeable active metabo... |
|
T64529 |
MDL-800
|
MDL 800,MDL800 |
Sirtuin
|
|
MDL-800 is a SIRT6 modulator with antitumor activity for the study of hepatocellular carcinoma and non-small cell lung cancer. |
|
T77599 |
Methyl retinoate
|
Retinoic acid, methyl ester |
Others
|
|
Methyl retinoate (Retinoic acid, methyl ester) induces aseptic inflammation at the site of administration in in vivo experiments, which causes an increase in the number of leukocytes in the blood and a decrease in the le... |
|
TP2505L |
LAH4 acetate
|
KKALLALALHHLAHLALHLALALKKA acetate,LAH4 acetate(184776-51-0 Free base) |
Antibacterial
|
|
LAH4 acetate is the α-helical structure of the designed amphoteric peptide antibiotic, which is capable of complexing DNA, associating with the cell surface membrane and wrapped in the endosome, which is destroyed with t... |
|
T6509 |
Galeterone
|
VN-124-1,TOK-001,VN/124-1,VN 124 |
P450
,
Androgen Receptor
|
|
Galeterone (VN 124) is an orally bioavailable small-molecule androgen receptor modulator and CYP17 lyase inhibitor with potential antiandrogen activity. Galeterone exhibits three distinct mechanisms of action: 1) as an a... |
|
T71703L |
Isomer-Turosteride
|
Isomer-Turosteride(Isomer-137099-09-3) |
Reductase
|
|
Isomer-Turosteride (Isomer-Turosteride(Isomer-137099-09-3)) is a novel 5 alpha-reductase inhibitor.The antiprostatic effect of Isomer-Turosteride in adult rats is associated with the inhibition of the conversion of T to ... |
|
T3157 |
COH29
|
RNR Inhibitor COH29 |
DNA/RNA Synthesis
|
|
COH29 (RNR Inhibitor COH29) is an orally available, aromatically substituted thiazole and inhibitor of the human ribonucleotide reductase (RNR), with potential antineoplastic activity. Upon oral administration, the RNR i... |
|
T14214 |
AMG 511
|
|
PI3K
|
|
AMG 511 is a potent and orally available pan inhibitor of class I PI3Ks(Kis of 4 nM, 6 nM, 2 nM and 1 nM for PI3Kα, β, δ and γ, respectively). It exhibits anti-tumor activity in mouse glioblastoma xenograft model[1]. AMG... |
|
T3934 |
Isavuconazonium sulfate
|
|
Antifungal
|
|
Isavuconazonium sulfate is hydrolyzed by plasma esterases to yield the active moiety isavuconazole. Isavuconazole binds to and inhibits the fungal cytochrome P450 family enzyme lanosterol 14-alpha-demethylase (CYP51), wh... |
|
T36493 |
CMLD-2
|
|
Apoptosis
,
HuR
|
|
CMLD-2 is an inhibitor of HuR-ARE interaction (Ki: 350 nM) that competitively binds HuR protein and disrupts its interaction with adenine element-rich (ARE) mRNA targets.CMLD-2 induces apoptosis and exhibits antitumor ef... |
|
T15200 |
Edotecarin
|
PF 804950,J 107088 |
Topoisomerase
|
|
|
|
T26452 |
A 80b
|
A80b,A-80b |
|
|
A-80b is a synthesized pyridazino[4,5-b]indole derivate with potent and long-lasting antihypertensive activity. The decrease in diastolic pressure was greater than the decrease in systolic pressure and cardiac frequency ... |
