| T5804 |
Pneumocandin B0
|
L-688786 |
Antibiotic
,
Antifungal
|
|
Pneumocandin B0 (L-688786) is a natural product and a key intermediate in the synthesis of the antifungal agent. |
| T7479 |
Ambroxide
|
(-)-Ambroxide |
Others
|
|
Ambroxide ((-)-Ambroxide) is a naturally product,is one of the key constituents of ambergris. |
| TN1243 |
3-Aminocoumarin
|
3-Amino-2-benzopyrone,3-aminochromen-2-one,Coumarin amine |
Others
|
|
3-Aminocoumarin (3-aminochromen-2-one) is the key intermediate for the metal complexes. |
| T8051 |
Bis(2-methyl-3-furyl)disulfide
|
Bis(2-methyl-3-furyl)disulphide |
Others
|
|
Bis(2-methyl-3-furyl)disulfide is a volatile sulfur compound that is a key contributor to the meat-like aroma in cooked meat. |
| T4921 |
Oxoadipic acid
|
2-Oxoadipic acid |
Endogenous Metabolite
|
|
Oxoadipic acid (2-Oxoadipic acid) is a key metabolite of the essential amino acids tryptophan and lysine.Important metabolite between the TCA cycle and lysine biosynthesis. Of interest for research on mitochondrial metab... |
| T20255 |
L-Galactose
|
Galactose, L- |
Endogenous Metabolite
|
|
L-Galactose (Galactose, L-) is a natural product that is widely found in plants and animals. L-Galactose has been shown to be a key intermediate in the molecular pathway for the conversion of D-glucose to oxalic acid in ... |
| T22300 |
Creatine monohydrate
|
Methylguanidoacetic acid monohydrate |
Others
,
Endogenous Metabolite
|
|
Creatine monohydrate (Methylguanidoacetic acid monohydrate) is a key player in the phosphagen energy system, especially in muscle and the brain. Creatine monohydrate is the primary source of ATP during high-intensity, sh... |
| T10939L |
L-Cystathionine
|
Cystathionine,ZINC1532680,L-(+)-Cystathionine,Cystathionine, L- |
Apoptosis
,
Endogenous Metabolite
|
|
|
| TN3689 |
Comanthoside A
|
Comanthosid A |
Others
|
|
Comanthoside A (Comanthosid A) is a naturally occurring flavonoid glycoside isolated from Comanthosphace japonica.Comanthoside A is also a key intermediate in the synthesis of Linaroside and Comanthoside B. Comanthoside ... |
| T5980 |
2-Ketoglutaric acid
|
|
Tyrosinase
,
Endogenous Metabolite
|
|
2-Ketoglutaric acid is a key molecule in the tricarboxylic acid cycle,is also connected to glutamic acid and glutamine metabolisms through the transamination reactions. |
| T6S0655 |
Corynoxeine
|
|
ERK
|
|
1. Corynoxeine is a potent ERK1/2 inhibitor of key PDGF-BB-induced VSMC proliferation and may be useful in the prevention and treatment of vascular diseases and restenosis after angioplasty. |
| T13502 |
3-Oxo-5β-cholanoic acid
|
Dehydrolithocholic acid |
ROR
|
|
|
| T2O2701 |
L-Ornithine hydrochloride
|
L(+)-Ornithine hydrochloride,(S)-2,5-Diaminopentanoic acid |
Others
,
Endogenous Metabolite
|
|
L-Ornithine hydrochloride ((S)-2,5-Diaminopentanoic acid) has an antifatigue effect by increasing the efficiency of energy consumption and promoting the excretion of ammonia. It is one of the key reactants in the urea cy... |
| T5770 |
Alisol B
|
|
RANKL/RANK
|
|
Alisol B may be a potential novel therapeutic molecule for bone disorders through targeting the differentiation of osteoclasts as well as their functions. Alisol B also inhibited RANKL-induced expression of NFATc1 and c-... |
| T21437 |
DSPS
|
DSPS (From soybeans),Phosphatidylserine(36:0),Dioctadecanoylphosphatidylserine,Distearoyl phosphatidylserine |
Others
|
|
DSPS (Dioctadecanoylphosphatidylserine) is a glycerophospholipid, an important phospholipid membrane component that plays a key role in cell cycle signaling. DSPS can regulate cellular activity and mediate apoptosis. DSP... |
| T5249 |
1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine
|
1,2-DSPE,1,2-Distearoyl-sn-glycero-3-phosphoethan |
Others
,
Endogenous Metabolite
|
|
1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine (1,2-DSPE) is a phosphatidylethanolamine (PE or GPEtn). The stearic acid moieties are derived from animal fats, coco butter, and sesame oil. Phospholipids, are ubiquitou... |
| T10065L |
2',3'-cGAMP sodium
|
2'-3'-cyclic GMP-AMP sodium |
STING
,
cGAS
|
|
2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium), a cGAMP synthase (cGAS) affecting cytoplasmic DNA production as a second messenger, is a transmembrane bridging protein that is a key component of the cellular innate imm... |
| T22446 |
NADP disodium salt
|
Disodium NADP,Triphosphopyridine nucleotide disodium salt |
Others
|
|
NADP disodium salt (Disodium NADP) is a nicotinamide adenine dinucleotide. NADP disodium salt is a key redox cofactor for electron transfer in the metabolism, serves as an electron carrier in a number of reactions, being... |
| T4928 |
L-Kynurenine
|
(S)-Kynurenine |
AhR
,
Aryl Hydrocarbon Receptor
,
Endogenous Metabolite
|
|
L-Kynurenine ((S)-Kynurenine) is a key intermediate in the breakdown pathway of tryptophan. L-Kynurenine is a substrate of kynureninase, KMO, and KAT associated with the suppression of antitumor immune responses. It has ... |
| T4920 |
2-Ketoglutaric acid Sodium
|
Oxoglutaric acid,AKG,2-oxoglutarate monobasic,α-Ketoglutaric acid sodium salt |
Tyrosinase
,
Endogenous Metabolite
|
|
2-Ketoglutaric acid Sodium (AKG) is a key molecule in the TCA cycle. It can be produced from glutamate by oxidative deamination via glutamate dehydrogenase and as a product of pyridoxal phosphate-dependent transamination... |
| T2133 |
Adenosine monophosphate
|
5'-Adenylic acid,AMP,Adenosine 5'-monophosphate |
Endogenous Metabolite
,
AMPK
|
|
Adenosine monophosphate (AMP) is a purine ribonucleoside 5'-monophosphates and a key cellular metabolite in signal transduction and regulation of energy homeostasis.It has a role as an EC 3.1.3.11 (fructose-bisphosphatas... |
| T5079 |
Adenosine 5'-diphosphate sodium salt
|
Adenosine-5'-diphosphate trisodium salt,ADP sodium salt |
Others
,
Endogenous Metabolite
|
|
Adenosine 5'-diphosphate sodium salt (ADP sodium salt) is an adenine nucleotide that is phosphorylated into ATP by ATPase. This phosphorylation is a key part of cellular homeostatis as it allows for energy storage and is... |
| T5243 |
(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl ditetradecanoate
|
DMPE,1,2-Dihexadecanoyl-sn-glycero-3-phosphoethanolamine,1,2-Dimyristoyl-sn-glycero-3-PE |
Others
,
Endogenous Metabolite
|
|
(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl ditetradecanoate (DMPE) is a phosphatidylethanolamine (PE or GPEtn). It is a glycerophospholipid in which a phosphorylethanolamine moiety occupies a glycer... |
| T2966 |
Beta-Sitosterol
|
Cupreol,Beta-Sitosterol,β-Sitosterol,Azuprostat,SKF 14463,22,23-Dihydrostigmasterol,Betaprost |
Apoptosis
,
Lipase
,
Endogenous Metabolite
|
|
Beta-Sitosterol (SKF 14463) has recently been shown to induce G2/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways. Beta-Sitosterol (SKF 14463) , a main dietary phytosterol foun... |
| TN6508 |
Trachelogenin
|
(-)-Trachelogenin |
Virus Protease
,
c-Myc
,
HCV Protease
,
Wnt/beta-catenin
|
|
Trachelogenin ((-)-Trachelogenin), isolated from Combretum fruticosum, is an HCV entry inhibitor with anti-proliferative effects. Its mechanism is related to affecting the phosphorylation of key proteins such as β-Cateni... |
| T4889 |
2,6-Diaminoheptanedioic acid
|
|
Others
,
Endogenous Metabolite
|
|
Diaminopimelic acid or DAPA is a lysine-like amino acid derivative that is a key component of the bacterial cell wall. DAPA is incorporated or integrated into peptidoglycan of gram negative bacteria and is the attachment... |
| T6S1315 |
Oroxylin A
|
6-Methoxybaicalein,Baicalein 6-methyl ether |
Virus Protease
,
HIF/HIF Prolyl-Hydroxylase
,
Autophagy
|
|
1. Oroxylin A (Baicalein 6-methyl ether) has various anti-tumor effects including apoptosis, cell cycle arrest, drug-resistant reversion. 2. Oroxylin A possesses abilities of inhibiting the ATRA-induced IL-6 production v... |
| T6S1572 |
Sauchinone
|
|
ERK
,
p38 MAPK
,
NF-κB
|
|
1. Sauchinone is a useful adjunctive treatment for bacterial infection. 2. Sauchinone, an active lignan found in Saururus chinensis, to regulate the activation of HSCs, to prevent liver fibrosis, and to inhibit oxidative... |
| T4838 |
(S)-Malic acid
|
L-(-)-Malic acid,(S)-(-)-HYDROXYSUCCINIC ACID,(S)-2-Hydroxysuccinic acid |
Others
,
Endogenous Metabolite
|
|
(S)-Malic acid ((S)-2-Hydroxysuccinic acid) is a tart-tasting organic dicarboxylic acid that plays a role in many sour or tart foods. Apples contain malic acid, which contributes to the sourness of a green apple. Malic a... |
| T40758 |
Hydrastinine
|
|
|
|
Hydrastinine, a key alkaloid component found in Hydrastis canadensis (goldenseal), serves as an effective hemostatic agent. |
| T13732 |
Hydroxy-Epsilon-Sanshool
|
|
Others
|
|
Hydroxy-Epsilon-Sanshool is an alkyl amide isolated from Zanthoxylum bungeanum. Hydroxy-Epsilon-Sanshool produces key tingling and numbing chemosensation. |
| T20447 |
L-Linalool
|
p-Linalool |
|
|
L-Linalool is the jasmine tea, spruce essential oil, and young leaves of Litchi chinensis Sonn key volatile compound. |
| T10025 |
1-PeCSO
|
S-1-Propenyl-L-cysteine sulfoxide |
Others
|
|
1-PeCSO is isolated from onion or garlic bulbs. It acts as a key compound in garlic greening and reacts with lachrymatory factor synthase. |
| T80953 |
Tremulacin
|
|
|
|
Tremulacin, a key glucoside found in the barks and leaves of various species of Populus, demonstrates significance [1]. |
| T10074 |
2-Keto-D-Glucose
|
D-Glucosone |
Others
|
|
2-Keto-D-Glucose (D-Glucosone) is a key intermediate in a secondary metabolic pathway leading to the antibiotic Cortalcerone. It is found in various natural sources, including fungi, algae, and shellfish. |
| TN1952 |
Moracin P
|
|
Others
,
ROS
,
HIF
|
|
Moracin P exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1), which is a key mediator during adaptation of cancer cells to tumour hypoxia. |
| TN4473 |
Macrocarpal A
|
|
Antifection
|
|
Macrocarpal A is the key component that stimulates the synthesis of ceramide in the stratum corneum. Macrocarpal A has cytotoxic, and antibacterial activities. |
| T40458 |
3-Keto petromyzonol
|
|
|
|
3-Keto petromyzonol, a key constituent of Sea lamprey male sex pheromones, governs the synthesis and release of gonadotropin releasing hormone (GnRH). This in turn regulates the hypothalamic-pituitary-gonadal (HPG) outpu... |
| T10194 |
7-Methylguanine
|
|
Others
|
|
7-Methylguanine is a metabolite of DNA methylation. It can be generated by methylating agents and used as a probe of DNA–protein interactions and a key component of the DNA sequencing method. |
| TN4016 |
Ethyl 2,4,6-trihydroxybenzoate
|
|
Liver X Receptor
|
|
Ethyl 2,4,6-trihydroxybenzoate is a dual-LXR modulator that regulates the expression of key genes in cholesterol homeostasis in multiple cells without inducing lipid accumulation in HepG2 cells. It suppresses cellular ch... |
| TN3725 |
Cucurbitadienol
|
|
|
|
Cucurbitadienol has significant anti-inflammatory, anti-tumor effect, is also CucurbitacinBE compounds biosynthesis the key intermediate. Cucurbitadienol synthase, the first committed enzyme for cucurbitacin biosynthesis... |
| T10910 |
Cycloartenol
|
|
Others
|
|
Cyclopentanol is a plant sterol compound and one of the key precursors for biosynthesis of various sterol compounds. Cycloartenol inhibits the migration of glioma cells and inhibits the phosphorylation of p38 MAP kinase.... |
| TN1783 |
Isolicoflavonol
|
|
Lipid
|
|
Isolicoflavonol is a potential cancer chemopreventive agent. |
| T83902 |
Polymyxin E1 sulfate
|
Colistin A sulfate |
|
|
Polymyxin E1, a peptide antibiotic and key component of the cationic lipopeptide antibiotic colistin, was initially extracted from B. polymyxa. It demonstrates effectiveness against P. aeruginosa and E. coli, with minimu... |
| TN6198 |
Mahanine
|
|
|
|
Mahanine has effects on the activation of the apoptotic pathway in human leukemia U937 cells, causes the mitochondrial membranes to lose their permeability, resulting in caspase-3 activation and apoptosis. Mahanine can r... |
| TN1951 |
Moracin O
|
|
HIF
|
|
Moracin O shows significant neuroprotective, and analgesic activities, it also has a strong protective influence against doxorubicin-induced cardiomyopathy in H9c2 cells with the EC50 value of 4.5 ± 1.3 μM. Moracin O exh... |
| T83904 |
Polymyxin E2 sulfate
|
Colistin B sulfate |
|
|
Polymyxin E2, a key component of the cationic lipopeptide antibiotic colistin, was originally derived from B. polymyxa and serves as a peptide antibiotic. It exhibits effective antibacterial activity against the plant pa... |
| T82822 |
Brassicanate A sulfoxide
|
|
|
|
Brassicanate A sulfoxide, isolated from Brassica oleracea [1], exhibits herbicidal properties by inhibiting the biosynthesis of essential amino acids in plants. It operates by binding to key enzymes such as dihydroxyacid... |
| T72581 |
SARS-CoV MPro-IN-2
|
|
|
|
SARS-CoV MPro-IN-2 effectively inhibits the SARS-CoV-2 main protease (M pro), crucial for the virus's replication and transcription in host cells, with an IC50 value of 72.07 nM. Given its significant role in processing ... |
| TN3364 |
Agrimonolide
|
|
Apoptosis
,
Dehydrogenase
,
p38 MAPK
,
ROS
,
JAK
|
|
Agrimonolide, a compound derived from isocoumarins and found mainly in the herb Agrimonia pilosa Ledeb, has significant biological activity. agrimonolide exerts anti-inflammatory effects by inhibiting lipopolysaccharide ... |
