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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T13865 | Resorcinolnaphthalein | RAAS | |
Resorcinolnaphthalein is a specific enhancer of angiotensin-converting enzyme 2 (ACE2) (EC50 value of 19.5 μM). | |||
T26046 | Razoxane | Topoisomerase | |
Razoxane is used as an antimitotic agent with immunosuppressive properties. | |||
T10696 | CB2 modulator 1 | Cannabinoid Receptor | |
CB2 modulator 1 is a potent CB2 modulator. It can be used for the research for immune disorders, osteoporosis, inflammation, renal ischemia. | |||
T6683 | STF-62247 | STF 62247 | Estrogen/progestogen Receptor , Autophagy |
STF-62247 is TGN inhibitor with IC50 of 0.625 μM and 16 μM in RCC4 and RCC4/VHL cells, respectively. | |||
T0114 | Trichlormethiazide | Naqua,Metahydrin,Trichlormetazid | ATPase , Carbonic Anhydrase |
Trichlormethiazide (Naqua) is a short-acting, 3-dichloromethyl derivative of hydrochlorothiazide, belonging to the class of thiazide diuretics. Trichlormethiazide appears to block the active reabsorption of chloride and ... | |||
T2058 | Palosuran | ACT-058362 | GPR |
Palosuran (ACT-058362) (ACT-058362) is a new potent and specific antagonist of the human UT receptor. | |||
T2583 | Cilastatin | MK0791 | Proteasome , Antibacterial , Antibiotic |
Cilastatin (MK0791) is a renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cila... | |||
T4989 | Fosfomycin Tromethamine | Antibacterial , Antibiotic | |
An antibiotic produced by Streptomyces fradiae. | |||
T8494 | NS-3-008 hydrochloride | NS-3-008 HCl | Others |
NS-3-008 hydrochloride (NS-3-008 HCl) is a transcriptional G0/G1 switch 2 (G0s2) inhibitor( IC50 of 2.25 μM). | |||
T1410 | Torsemide | AC-4464,JDL-464,Torasemide | Na-K-Cl cotransporter |
Torsemide (AC-4464) is an anilinopyridine sulfonylurea belonging to the class of loop diuretics. Torsemide has a prolonged duration of action compared to other loop diuretics, is extensively protein bound in plasma and h... | |||
T7714 | Temocapil | Tyrosinase | |
Temocapril is an inhibitor of tyrosine kinase. | |||
T12883 | Fezagepras | PBI-4050,Setogepram | GPR |
Fezagepras (Setogepram) is an orally active GPR40 agonist and is an antagonist or inverse agonist of GPR84 with anti-inflammatory, anti-fibrotic, and anti-proliferative actions. | |||
T9831 | MKC-1 | Ro-31-7453 | Apoptosis , Akt , Microtubule Associated , mTOR |
MKC-1 (Ro-31-7453) is an orally bioavailable, small-molecule, bisindolylmaleimide cell cycle inhibitor with potential antineoplastic activity. MKC-1 and its metabolites inhibit tubulin polymerization, blocking the format... | |||
T3131 | Fosfomycin calcium | Phosphomycin calcium salt,Fosmicin | Antibacterial , Antibiotic |
Fosfomycin calcium (Phosphomycin calcium salt) is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis. | |||
T2456 | Tivozanib | AV-951,KRN951 | VEGFR , PDGFR , Ephrin Receptor |
Tivozanib (KRN951) is an orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities. | |||
T4583 | PFI-2 hydrochloride | (R)-PFI-2 hydrochloride,PFI-2 HCl | Histone Methyltransferase |
PFI-2 hydrochloride ((R)-PFI-2 hydrochloride) is a potent, highly selective, and cell-active inhibitor of the methyltransferase activity of SETD7 (IC50: 2 nM), 500 fold active than (S)-PFI-2. | |||
T13748 | L-2-Hydroxyglutaric acid disodium | (S)-2-Hydroxyglutaric acid disodium | Histone Demethylase , Mitochondrial Metabolism |
L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium) is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activ... | |||
T16708 | R-268712 | ALK , TGF-beta/Smad | |
R-268712 is a specific activin receptor-like kinase 5 (ALK5) inhibitor(IC50 of 2.5 nM). It is also an orally active transforming growth factor-β type I receptor inhibitor. | |||
T1615 | Irbesartan | SR-47436,BMS-186295 | Apoptosis , RAAS |
Irbesartan (SR-47436) is an Angiotensin 2 Receptor Blocker. The mechanism of action of irbesartan is as an Angiotensin 2 Receptor Antagonist. | |||
TQ0157 | EIPA | L593754,MH 12-43 | Sodium Channel , TRP/TRPV Channel |
EIPA (L593754) (L593754, MH 12-43) is a TRPP3 channel inhibitor (IC50: 10.5 μM). It also inhibits Na+/H+-exchanger (NHE) and macropinocytosis. | |||
T6698 | Temocapril hydrochloride | CS-622 HCl,Acecol,Temocapril HCl,CS-622 | RAAS |
Temocapril hydrochloride (CS-622 HCl), the hydrochloride of Temocapril, is a long-acting ACE inhibitor used for the therapy of hypertension. | |||
T1987 | PFI-2 | PFI2,PFI 2,(R)-PFI-2 | Histone Methyltransferase |
PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other methyltransferases and other non-epigenetic targets. | |||
T0248 | Clorprenaline hydrochloride | Clorprenaline HCl,NSC 334693 | Adrenergic Receptor |
Clorprenaline hydrochloride (Clorprenaline HCl) is a beta-2 adrenergic agonist with bronchodilator activity. | |||
T13142L | Theodrenaline hydrochloride | Theodrenaline hydrochloride(13460-98-5 Free base) | SARS-CoV |
Theodrenaline hydrochloride is an inhibitor targeting SARS-CoV-2 for the study of hypotension induced by spinal anesthesia. | |||
T25984 | (±)-Prenalterol | H80/62,H-80/62,H 80/62 | Adrenergic Receptor |
(±)-Prenalterol (H 80/62) is a new cardioselective positive inotropic compound that is an agonist of beta-2- and beta-1-adrenergic receptors and can be used to study chronic congestive heart failure. | |||
T0948 | Adrenalone hydrochloride | Adrenalone HCl | Adrenergic Receptor |
Adrenalone hydrochloride (Adrenalone HCl) is a dopamine β-oxidase inhibitor with a similar structure to the norepinephrine transporter (NET) ligand, with an IC50 of 36.9 μM. It is an adrenergic agonist that acts as a loc... | |||
T1056 | Isoprenaline hydrochloride | NCI-c55630,Isoproterenol hydrochloride,Isoprenaline HCl | PI3K , Endogenous Metabolite , Adrenergic Receptor , PDE |
Isoprenaline hydrochloride (NCI-c55630) is a potent beta-adrenergic agonist with the peripheral vasodilator, bronchodilator, and cardiac stimulating properties. | |||
T0871 | Noradrenaline bitartrate | Adrenergic Receptor | |
Norepinephrine bitartrate acts directly on the α- and β-adrenergic receptors. Norepinephrine Bitartrate is a bitartrate salt of norepinephrine, a synthetic phenylethylamine that mimics the sympathomimetic actions of the ... | |||
T32536 | L-Adrenalin ascorbinate | Tonhormon | |
l-Adrenalin ascorbinate is a bioactive chemical. | |||
T32697 | Levisoprenaline | (R)-Isoprenaline,Levisoprenalina,BRN-3203136,BRN 3203136,Proternol L | |
Levisoprenaline is a bioactive chemical. | |||
TMIH-0165 | Clorprenaline-d7 | ||
Clorprenaline-d7 is a deuterated compound of Clorprenaline. Clorprenaline has a CAS number of 3811-25-4. | |||
T33361 | Metiprenaline | Egyt 402,Egyt-402,Egyt402 | |
Metiprenaline is a biochemical. | |||
T69000 | Prenalterol hydrochloride | ||
Prenalterol hydrochloride is a partial adrenergic agonist with functional beta 1-receptor specificity and inotropic effect. It is effective in the treatment of acute cardiac failure, postmyocardial infarction low-output ... | |||
T27540 | Hexoprenaline Sulfate | ST-1512,Argocian,Gynipral | |
Hexoprenaline Sulfate is a selective beta2-adrenoreceptor agonist. Hexoprenaline Sulfate is active in man as a bronchodilator by the oral or intravenous routes and by inhalation. Hexoprenaline Sulfate is indicated for us... | |||
T13142 | Theodrenaline | (±)-Theodrenaline | Others |
Theodrenaline is a cardiac stimulant, also acts as an agent of anti-hypotensive together with cafedrine. | |||
T60261 | Clorprenaline | ||
Clorprenaline, a potent β2-adrenergic agonist, effectively promotes muscular mass growth in animals while reducing fat accumulation, making it a promising lean meat-enhancing feed additive [1]. | |||
T69151 | Adrenaline sulfate | ||
Adrenaline sulfate, an orally active hormone secreted by the adrenal glands' medulla, acts as an α-adrenergic and β-adrenergic receptor agonist. It is utilized in treating anaphylaxis and holds potential for cardiac arre... | |||
T25499 | Hexoprenaline | ||
Hexoprenaline is a stimulant of adrenergic beta 2 receptors used as a bronchodilator, antiasthmatic agent, and tocolytic agent. | |||
T1400L | Demeclocycline | Ledermycin,Bioterciclin,Deteclo,Declostatin,Deganol | Antibacterial |
Demeclocycline (Declostatin) is a tetracycline antibiotic produced by a strain of Streptomyces aureofaciens.Demeclocycline has antimicrobial activity and inhibits the action of vasopressin on the renal tubules, leading t... | |||
T3064 | VTP-27999 | VTP27999 | RAAS |
VTP-27999 is an alkyl amine Renin inhibitor. VTP-27999 has been used in trials studying the basic science of Renal Function. | |||
TP1049L | Ornipressin Acetate(3397-23-7,free) | Orpressin,POR-8 | Others |
Ornipressin Acetate (POR-8) is a potent vasoconstrictor, hemostatic and renal agent. | |||
T22882 | JP1302 | Adrenergic Receptor | |
JP1302 is a selective α2C adrenoceptor antagonist with a Kb value of 16 nM and a Ki of 28 nM for human α2C receptors.JP1302 has antidepressant activity, disrupts the FACT complex and degrades histone H1.JP1302 has been u... | |||
T50000 | 2-Iodohippuric Acid | Others | |
2-Iodohippuric Acid can be used to measure renal clearance for renal function studies, and for the diagnosis of certain diseases, such as liver and kidney disease. In addition, it is used in the synthesis of certain drug... | |||
T24818 | Sparfosic Acid | NSC224131,NSC-224131,Acide sparfosique,N-Phosphonacetyl-L-aspartate,NSC 224131 | Apoptosis |
Sparfosic Acid (Acide sparfosique) is an aspartate carbamoyltransferase inhibitor with antitumor activity and can be used to study advanced renal cell carcinoma. | |||
T24270 | KS370G | KS-370-G,KS 370 G,Caffeic Acid Phenethyl Amide | |
KS370G (Caffeic Acid Phenethyl Amide) inhibits UUO-induced renal fibrosis marker expression. KS370G is an orally active hypoglycemic and cardioprotective agent that reduces collagen deposition in obstructed kidneys and s... | |||
T16777 | ROC-325 | Apoptosis , Autophagy | |
ROC-325 is an effective and orally active inhibitor of autophagy with anticancer activity. ROC-325 induces renal cell carcinoma apoptosis and exhibits favorable selectivity. | |||
T27323 | FK-453 | FK453,FK 453 | Adenosine Receptor |
FK-453 is a potent antagonist of non-xanthine adenosine A1 receptor with diuretic and renal vasodilatory activity. | |||
T13881 | Dicirenone | SC26304 | ATPase , Glucocorticoid Receptor |
Dicirenone (SC26304) inhibits the Mineralocorticoid receptor (MR), aldosterone regulation of the urinary K+:Na+ ratio, and aldosterone binding to renal cytoplasmic and nuclear receptors. | |||
T5039 | Aminohippurate sodium | Sodium 4-aminohippurate Hydrate,Sodium p-aminohippurate,p-Aminohippuric acid sodium salt | Others |
Aminohippurate sodium (Sodium p-aminohippurate) is used as a diagnostic aid to measure effective renal plasma flow (ERPF) and excretory capacity. | |||
T14076 | A 839977 | A839977,A-839977 | P2X Receptor , Calcium Channel |
A 839977 is a selective P2X7 receptor antagonist with anti-inflammatory and analgesic activity that inhibits BzATP-induced calcium efflux from the P2X7 receptor for the study of renal fibrosis. |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T5669 | Citric acid monohydrate | Others | |
Citric Acid Monohydrate is a tricarboxylic acid found in citrus fruits. Citric acid is used as an excipient in pharmaceutical preparations due to its antioxidant properties. It maintains stability of active ingredients a... | |||
T5S0636 | Citric acid | Citro,Citretten | Apoptosis , Others , Endogenous Metabolite , Antibacterial , Antibiotic |
1. Citric acid (Citro) (1-2 g/kg) can decrease brain lipid peroxidation and inflammation, liver damage, and DNA fragmentation. 2. Citric acid denture cleansers can reduce C. albicans biofilm accumulation and cell viabili... | |||
T22311 | Djenkolic Acid | jengkolic acid,Djenkolate,S,S'-Methylenebiscysteine | Others |
Djenkolic Acid (S,S'-Methylenebiscysteine) is a naturally occurring sulfur-containing amino acid extracted from djenkol beans(Archidendron pauciflorum), which is native to Southeast Asia. It is an uncommon but important ... | |||
T8262 | Fosfomycin sodium | Fosfomycin Disodium | Antibacterial , Antibiotic |
Fosfomycin sodium is a bactericidal, low-molecular weight, broad-spectrum antibiotic, with putative activity against several bacteria, including multidrug-resistant Gram-negative bacteria, by irreversibly inhibiting an e... | |||
T3999 | D(+)-Galactosamine hydrochloride | D-Galactosamine HCl | Others |
D(+)-Galactosamine hydrochloride (D-Galactosamine HCl) hepatotoxicity is associated with endotoxin sensitivity and mediated by lymphoreticular cells in mice. | |||
T3033 | Deoxycorticosterone acetate | DOC acetate,Cortexone acetate,11-Deoxycorticosterone acetate | Glucocorticoid Receptor , Endogenous Metabolite , Adrenergic Receptor |
Deoxycorticosterone acetate (Cortexone acetate) is the 21-acetate derivative of desoxycorticosterone, used for intramuscular injection for replacement therapy of the adrenocortical steroid. | |||
T8150 | Nudifloramide | 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide | PARP , Endogenous Metabolite |
Nudifloramide (1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide) is one of the end degradation products of nicotinamide-adenine dinucleotide (NAD). | |||
T1071L | DL-Adrenaline Hydrochloride | Adrenergic Receptor | |
DL-Adrenaline Hydrochloride is the hydrochloride salt of the naturally occurring sympathomimetic amine with vasoconstricting, intraocular pressure-reducing activities. | |||
TN4258 | Isocuparenal | Others | |
Isocuparenal is a natural product for research related to life sciences. The catalog number is TN4258 and the CAS number is 16982-01-7. | |||
T20173 | Noradrenaline tartrate | NSC 169106,NSC-169106,l-Noradrenaline d-bitartrate,NSC169106,Norepinephrine bitartrate | |
Norepinephrine bitartrate is a precursor of epinephrine. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceru... | |||
T3P2855 | Chamigrenal | EGFR , NOS , PAFR , COX , Prostaglandin Receptor | |
β-Chamigrenal has anti-inflammatory activity, it has inhibitory effects on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7 macrophages. Chamigrenal shows platelet-activating factor an... | |||
TN6974 | (-)-Isobicyclogermacrenal | ||
(-)-Isobicyclogermacrenal is a natural product. | |||
T4238 | Glycocyamine | 2-Guanidinoacetic acid,Guanidoacetic acid | Others , Endogenous Metabolite |
Glycocyamine (2-Guanidinoacetic acid), a precursor of creatine, is a replacement of dietary arginine and could support overall energy homeostasis of the bird. Glycocyamine is an important marker for renal failure, kidney... | |||
T4959 | DL-Mannitol | Mannitol | Others |
DL-Mannitol is a osmotic diuretic, it may play a role in reducing off-target 68Ga-PSMA renal uptake | |||
TN2430 | Glucodigifucoside | ||
Glucodigifucoside, a cardiac glycoside that can be isolated from digitalis seeds, is specifically cytotoxic to human renal adenocarcinoma cells. | |||
TQ0119 | Cirsimaritin | GABA Receptor | |
T1436 | 4-Aminohippuric Acid | p-Aminohippuric acid | Amino Acids and Derivatives , Endogenous Metabolite |
4-Aminohippuric Acid is the glycine amide of 4-aminobenzoic acid. Its sodium salt is used as a diagnostic aid to measure effective renal plasma flow (ERPF) and excretory capacity. | |||
T5040 | Medroxyprogesterone | Estrogen/progestogen Receptor , Progesterone Receptor | |
Medroxyprogesterone is used in the treatment of renal carcinoma. It is a synthetic progestational hormone used in veterinary practice as an estrus regulator. | |||
T7344 | SDMA | NG,NG'-Dimethyl-L-arginine,Symmetric dimethylarginine | Endogenous Metabolite |
SDMA (Symmetric dimethylarginine) is the most potent endogenous inhibitor of nitric oxide synthase (NOS), with higher levels in patients with end-stage renal disease (ESRD). | |||
T3869 | Skimmin | Skimmine | Others |
Skimmin (Skimmine) has anti-inflammatory activity, can significantly improve renal function and suppress the IgG deposition as well as the development of glomerular lesions in a rat model of membranous glomerulonephritis... | |||
T5289 | N-Acetyl-L-arginine dihydrate | N-Ac-L-arg-OH | Others , Endogenous Metabolite |
N-Acetyl-L-arginine dihydrate (N-Ac-L-arg-OH) is one of the guanidino compounds found elevated in the serum of a hemodialyzed renal insufficient (uremic) pediatric population. | |||
T0414 | D-Mannitol | Mannite,Mannitol,Osmitrol | Apoptosis , Dehydrogenase , Endogenous Metabolite |
D-Mannitol (Mannitol) is a diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any metabolism can take place. It can be used to t... | |||
T2S0850 | Malic acid | E 296,2-Hydroxysuccinic acid,Hydroxybutanedioic acid,FDA 2018,Deoxytetraric acid,Pomalus acid | Others , Endogenous Metabolite |
1. Malic acid (Pomalus acid) did reduce populations of L. monocytogenes on poultry. 2. Malic acid supplementation may be useful for conservative treatment of calcium renal stone disease by virtue of its capacity to induc... | |||
T3857 | Magnolin | (+)-Magnolin | ERK |
Magnolin reduces the renal oxidative stress, suppresses caspase-3 activity, and increases Bcl-2 expression in vivo and in vitro. Magnolin has anti-inflammatory and antioxidative effects. | |||
T1614 | Hydrocortisone | Cortisol | Glucocorticoid Receptor , Endogenous Metabolite |
Hydrocortisone (Cortisol) is a glucocorticoid hormone secreted by the adrenocortex. Hydrocortisone agonizes the glucocorticoid receptor, which promotes proteolytic metabolism, gluconeogenesis, capillary wall stabilizatio... | |||
T20793 | Magnesium Lithospermate B | Monomethyl lithospermate B,Lithospermate B | Others |
Magnesium Lithospermate B is a natural product activates eNOS and ameliorates endothelial dysfunction in diabetes by enhancing vasodilation in addition to reducing oxidative stress, it can protecte cardiomyocytes from is... | |||
T3005 | 4-Hydroxychalcone | P-Cinnamoylphenol | Others , NF-κB |
4-Hydroxychalcone (P-Cinnamoylphenol) attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice. | |||
T7040 | Angiotensin II human | DRVYIHPF,Angiotensin II,Hypertensin II,Ang II | Apoptosis , RAAS |
Angiotensin II human (Ang II) is a biologically active peptide, a vasoconstrictor. Angiotensin II interacts with AT1R and AT2R to regulate blood pressure, stimulate sympathetic nerves, and increase aldosterone biosynthes... | |||
T4904 | 1-Methylguanidine hydrochloride | Others , Endogenous Metabolite | |
Methylguanidine (MG) is a guanidine compound deriving from protein catabolism. It is also a product of putrefaction. Methylguanidine is a suspected uraemic toxin that accumulates in renal failure, however it also exhibit... | |||
PDK0014 | 3-Methylxanthine | Endogenous Metabolite | |
3-Methylxanthine, a xanthine derivative, is a cyclic guanosine monophosphate (GMP) inhibitor, with an IC50 of 920 μM on guinea-pig isolated trachealis muscle.3-Methylxanthine inhibited xanthine crystallization, it could ... | |||
T3S1227 | Aristolactam I | Aristolactam,Aristololactam I,Aristololactum | Apoptosis , Caspase |
1.Aristolactam I (Aristololactum) has cytotoxic potency, mediated through the induction of apoptosis in a caspase 3-dependent pathway. 2. The effects of Aristololactam I may be mediated by different mechanisms except TGF... | |||
T3414 | Morroniside | Apoptosis , MMP , Pyroptosis | |
Morroniside would act as a regulator of hepatic inflammatory reactions and lipid metabolism in db/db mice. It exhibits protective effects against diabetic renal damage and human umbilical vein endothelial cells, by inhib... | |||
T5S0761 | Nitidine chloride | Apoptosis , ERK , FAK , p38 MAPK , NF-κB , Topoisomerase , STAT , Parasite | |
1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721 cells in vitro in a time- and dose-dependent manner and id... | |||
T2S2043 | Dracorhodin perchlorate | Dracorhodin perochlorate,Dracohodin perochlorate | Apoptosis , Others |
Dracorhodin perchlorate inhibits cell growth, and induces apoptosis in fibroblasts in a dose-and time-dependent manner, arresting cell cycle at G1 phase, may as a candidate for anti-breast cancer. Dracorhodin perchlorate... | |||
T5248 | (R)-3-Hydroxybutanoic acid | Others , Endogenous Metabolite | |
3-hydroxybutyric acid is involved in the synthesis and degradation of ketone bodies. Like the other ketone bodies (acetoacetate and acetone), levels of beta-hydroxybutyrate are raised in the blood and urine in ketosis. B... | |||
T3877 | Esculentoside A | NF-κB , COX | |
Esculentoside A can suppress inflammatory responses in LPS-induced ALI through inhibition of the NF-κB and mitogen-activated protein kinase signaling pathways. Esculentoside A may be useful for the treatment of autoimmun... | |||
T6S1917 | Schisandrol B | Gomisin A,TJN-101,Besigomsin,Gamma-Schisandrin,Schizandrol B,Wuweizi alcohol-B | P450 , Reactive Oxygen Species , Autophagy |
1. Schisandrol B (Besigomsin) may exert neuroprotective effects by attenuating the microglia-mediated neuroinflammatory response via inhibiting the TLR4-mediated NF-κB and MAPKs signaling pathways. 2. Schisandrol B has a... | |||
T8053 | N-Acetyl-L-arginine | Ac-Arg-OH | Endogenous Metabolite |
N-Acetyl-L-arginine (Ac-Arg-OH) belongs to the class of organic compounds known as n-acyl-l-alpha-amino acids. These are n-acylated alpha amino acids which have the L-configuration of the alpha-carbon atom. N-a-Acetyl-L-... | |||
T4938 | Potassium 1H-indol-3-yl sulfate | Indoxyl sulfate potassium salt,Potassium 3-indoxyl sulfate | AhR , Endogenous Metabolite |
Potassium 1H-indol-3-yl sulfate (Potassium 3-indoxyl sulfate) is an agonist for the human Aryl Hydrocarbon Receptor (AhR). The Aryl Hydrocarbon Receptor (AhR) has recently emerged as a pathophysiological regulator of imm... | |||
T13670 | (E)-Ligustilide | Others | |
(E)-Ligustilide has renal protection and was isolated from Angelica sinensis. | |||
TN1912 | Marinobufogenin | Marinobufagenin | ATPase , EGFR |
Marinobufagenin, a cardiotonic steroid, its increased concentrations are important in the cardiac disease and oxidant stress state seen with renal failure. | |||
T72798 | Ganodermaones B | ||
Ganodermaones B is a renal fibrosis inhibitor. Ganodermaones B inhibits TGF-β1-induced collagen I and fibronectin expression . | |||
T11513 | Gum arabic | Arabic gum | Others |
Gum Arabic, a branched-chain, complex polysaccharide derived from A. Senegal, exhibits antioxidant properties and offers protection against experimental hepatic, renal, and cardiac toxicities. Additionally, it finds appl... | |||
T13749 | L-2-Hydroxyglutaric acid | (S)-2-Hydroxyglutaric acid | Others |
L-2-Hydroxyglutaric acid, an epigenetic modifier and potential oncometabolite in renal cancer, impedes mitochondrial creatine kinase (Mi-CK) activity, exhibiting Km and Ki values of 2.52 mM and 11.13 mM, respectively. Ad... | |||
T83110 | Angulatin K | ||
Angulatin K, a sesquiterpene polyol ester naturally occurring in the root bark of Celastrus angulatus [1], exhibits anti-cancer properties effective against a variety of solid tumors, including renal, breast, and lung. | |||
TN4381 | Karounidiol | Others | |
Karounidiol exhibits cytotoxicity especially against a human renal cancer, it markedly suppresses the promoting effect of TPA (1 microgram/mouse) on skin tumor formation in mice following initiation with 7,12-dimethylben... | |||
TN3380 | Alloisoimperatorin | AChR | |
Alloisoimperatorin is a candidate of AChE inhibitors, it displays potent antioxidant effects against the DPPH radical and against renal epithelial cell injury by using AAPH to generate peroxyl radicals in vitro. Alloisoi... | |||
TMA1743 | Ergosterol peroxide | ERK , VEGFR , p38 MAPK , Wnt/beta-catenin , Akt , JAK , CDK , JNK , STAT , Antifection | |
Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Foxo3a activity by inhibiting pAKT and c-Myc and activating pr... | |||
TN3753 | Dalbergioidin | Tyrosinase , ROS , Akt , PI3K , TGF-beta/Smad | |
Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM. It shows a melanin biosynthesis inhibition zone in the culture plate of Streptomyces bikiniensis that has commonly been used as an indicator or... | |||
T81629 | OAT1/3-IN-2 | ||
OAT1/3-IN-2 (compound 8) is a dual inhibitor of OAT1 and OAT3 that demonstrates potential protective effects against Cys-Hg toxicity in HEK-OAT1 cells (10 μM) and may safeguard renal function. This compound is useful for... | |||
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カタログ番号 | 製品名 | Species | Expression System |
---|---|---|---|
TMPH-03132 | AVPR2 Protein, Pig, Recombinant (His & SUMO) | Sus scrofa (Pig) | E. coli |
Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption. AVPR2 Protein, Pig, Recombinant (His & SUMO) is expressed... | |||
TMPJ-00797 | LDHB Protein, Human, Recombinant (His) | Human | E. coli |
L-Lactate Dehydrogenase B Chain (LDH-B) is a member of the lactate dehydrogenase family that consists of three members, LDH-A, LDH-B and LDH-C; members of this family function as powerful markers for germ cell tumors. LD... | |||
TMPJ-00724 | LDHA Protein, Human, Recombinant (His) | Human | E. coli |
L-Lactate Dehydrogenase A Chain (LDHA) is an enzyme that catalyzes the conversion of L-lactate and NAD+ to pyruvate and NADH in the final step of anaerobic glycolysis. LDHA contains an N-terminal coenzyme binding region,... | |||
TMPH-03246 | AQP2 Protein, Rat, Recombinant (His) | Rat | E. coli |
Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Plays an essential rol... | |||
TMPH-02523 | AQP2 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Plays an essential rol... | |||
TMPJ-00755 | CRYAB Protein, Human, Recombinant (His) | Human | E. coli |
α Crystallin B Chain (CRYAB) is a cytoplasmic protein that belongs to the small heat shock protein (HSP20) family. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectiv... | |||
TMPJ-01010 | PLA2G16 Protein, Human, Recombinant (His) | Human | E. coli |
Group XVI Phospholipase A1/A2 (PLA2G16) belongs to the H-rev 107 family. PLA2G16 is expressed in a number of human tumors including ovarian carcinomas, lung carcinomas. PLA2G16 is involved in the regulation of differenti... | |||
TMPH-02880 | Renalase Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli |
Renalase Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 52.0 kDa and the accession number is A7RDN6. | |||
TMPY-02956 | Apolipoprotein L/APOL1 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
APOL1, also known as apolipoprotein L1, is a minor apoprotein component of HDL (High-density lipoprotein) or 'good cholesterol' which is synthesized in the liver and also in many other tissues, including pancreas, kidney... | |||
TMPJ-00071 | EPO/Erythropoietin Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Erythropoietin (EPO) is a glycoprotein hormone that is principally known for its role in erythropoiesis, where it is responsible for stimulating proliferation and differentiation of erythroid progenitor cells. Erythropoi... | |||
TMPY-04483 | IRAK4 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
Interleukin-1 receptor-associated kinase 4, also known as Renal carcinoma antigen NY-REN-64, IRAK-4, and IRAK4, is a member of the protein kinase superfamily, TKL Ser/Thr protein kinase family, and Pelle subfamily. IRAK4... | |||
TMPJ-00504 | Serpin A8 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Angiotensinogen is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Genetic variations in Angiotensinogen are associated with susceptibility to essential hyperten... | |||
TMPK-00526 | LRG1 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
Diabetic nephropathy (DN) is an important public health concern of increasing proportions and the leading cause of end-stage renal disease (ESRD) in diabetic patients. It is one of the most common long-term microvascular... | |||
TMPK-01128 | LRG1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Diabetic nephropathy (DN) is an important public health concern of increasing proportions and the leading cause of end-stage renal disease (ESRD) in diabetic patients. It is one of the most common long-term microvascular... | |||
TMPH-03293 | FGF-23 Protein, Rat, Recombinant (E. coli, His) | Rat | E. coli |
Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Regulator of vitamin-D metabolism. Negatively regulates osteoblasts differentiation and matrix mineralization. Ac... | |||
TMPJ-00931 | Serpin A4 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Serpin Peptidase Inhibitor, Clade A (α-1 Antiproteinase, Antitrypsin), Member 4 (Serpin A4) is a member of the Serpin family. Serpin A4 exists as a monomer and some homodimers. Serpin A4 is expressed by the liver and sec... | |||
TMPY-03460 | DCXR Protein, Human, Recombinant (His) | Human | E. coli |
DCXR, also known as HCR2, belongs to the short-chain dehydrogenases/reductases (SDR) family. It is highly expressed in kidney, liver and epididymis. In the epididymis, DCXR is mainly expressed in the proximal and dist... | |||
TMPH-02434 | PTH Protein, Cynomolgus, Recombinant (His & Myc) | Cynomolgus | E. coli |
PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells. PTH Protein, Cynomolgus,... | |||
TMPH-03348 | PTH Protein, Rat, Recombinant (His & Myc) | Rat | E. coli |
PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells. PTH Protein, Rat, Recomb... | |||
TMPH-02595 | Collectrin Protein, Mouse, Recombinant (His & Myc & SUMO) | Mouse | E. coli |
Plays an important role in amino acid transport by acting as binding partner of amino acid transporters SLC6A18 and SLC6A19, regulating their trafficking on the cell surface and their activity. May also play a role in tr... | |||
TMPK-00172 | B7-H4 Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells |
B7-H4, also known as B7x and B7S1, is a 50-80 kDa glycosylated member of the B7 family of immunomodulatory proteins.B7-H4 is up-regulated in several carcinomas in correlation with tumor progression and metastasis. A solu... | |||
TMPJ-00876 | FAH Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Fumarylacetoacetase belongs to the FAH family. Fumarylacetoacetase is primary expressed in liver and kidney. It exists as a homodimer and catalyzes the hydrolysis of 4-fumarylacetoacetate into fumarate and acetoacetate. ... | |||
TMPK-00751 | FSTL3 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Follistatin-like 3 (FSTL3) is a novel cytokine that regulates insulin sensitivity and counteracts activin/myostatin signalling. In the present study, regulation of FSTL3 in renal dysfunction was investigated in both huma... | |||
TMPH-03294 | FGF-23 Protein, Rat, Recombinant (His) | Rat | P. pastoris (Yeast) |
Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Regulator of vitamin-D metabolism. Negatively regulates osteoblasts differentiation and matrix mineralization. Ac... | |||
TMPK-01225 | MRC2 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
MRC2 (Mannose Receptor C Type 2) is a constitutively recycling endocytic receptor belonging to the mannose receptor family, which has been found to be closely involved with cancer metastasis. MRC2 expresses an extracellu... | |||
TMPK-00574 | MRC2 Protein, Canine, Recombinant (His) | Canine | HEK293 Cells |
MRC2 (Mannose Receptor C Type 2) is a constitutively recycling endocytic receptor belonging to the mannose receptor family, which has been found to be closely involved with cancer metastasis. MRC2 expresses an extracellu... | |||
TMPK-00151 | Complement Factor D/CFD Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages. Factor D is found at relatively high levels in glomeruli sugge... | |||
TMPJ-00457 | OGG1 Protein, Human, Recombinant | Human | E. coli |
Human N-Glycosylase/DNA Lyase(OOG1) is a DNA repair enzyme, which belongs to the type-1 OGG1 family. OOG1 incises DNA at 8-oxoG residues, and excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamido... | |||
TMPJ-01350 | XPNPEP3 Protein, Human, Recombinant (His) | Human | E. coli |
Probable Xaa-Pro Aminopeptidase 3 (XPNPEP3) is a member of the peptidase M24B family. XPNPEP3 has two isoforms and both are widely expressed. XPNPEP3 is localized in the Mitochondrion. XPNPEP3 catalyzes the release of an... | |||
TMPK-00138 | CXCL16 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
CXC chemokine ligand 16 (CXCL16) is a CXC soluble chemokine, an adhesion molecule and a cell surface scavenger receptor. CXCL16 regulates inflammation, tissue injury and fibrosis. Parenchymal renal cells, vascular wall c... | |||
TMPK-00671 | Complement Factor D/CFD Protein, Rhesus macaque, Recombinant (His) | Rhesus | HEK293 Cells |
Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages. Factor D is found at relatively high levels in glomeruli sugge... | |||
TMPK-00755 | Complement Factor D/CFD Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages. Factor D is found at relatively high levels in glomeruli sugge... | |||
TMPJ-00265 | Serpin F1 Protein, Mouse, Recombinant | Mouse | E. coli |
Serpin F1 is secreted Neurotrophic protein and belongs to the serpin family. Serpin F1 Highly expressed in the liver, gastric glandular mucosa and renal tubules. It is also expressed in the brain, heart, lung retina and ... | |||
TMPK-00469 | CXCL16 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
CXC chemokine ligand 16 (CXCL16) is a CXC soluble chemokine, an adhesion molecule and a cell surface scavenger receptor. CXCL16 regulates inflammation, tissue injury and fibrosis. Parenchymal renal cells, vascular wall c... | |||
TMPH-02431 | Legumain Protein, Cynomolgus, Recombinant (His & Myc) | Cynomolgus | Baculovirus Insect Cells |
Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Requir... | |||
TMPJ-01306 | CFHR5 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Complement factor H-related protein 5(FHR-5 for short), is a secreted protein which contains 9 Sushi (CCP/SCR) domains. It is expressed by the liver and secreted in plasma. The pattern of the deposits is similar to other... | |||
TMPH-00331 | ALS3 Protein, Candida albicans, Recombinant (B2M & His & Myc) | Candida albicans | E. coli |
Cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Plays an important role in the biofilm formation and pathogenesis of C.albicans infections. Necessary for C.albicans... | |||
TMPH-02432 | Legumain Protein, Cynomolgus, Recombinant (E. coli, His & Myc) | Cynomolgus | E. coli |
Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Requir... | |||
TMPY-02003 | FH/Fumarate Hydratase Protein, Human, Recombinant (His) | Human | E. coli |
Fumarate Hydratase (FH) is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extende... | |||
TMPY-00261 | Meprin beta Protein, Human, Recombinant (His) | Human | HEK293 Cells |
MEP1B (Meprin A Subunit Beta) is a Protein Coding gene. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the me... | |||
TMPY-01451 | MESDC2 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
MESD (Mesoderm Development LRP Chaperone) is a Protein Coding gene. LDLR chaperone MESD, also known as Mesoderm development protein, Mesoderm development candidate 2, Renal carcinoma antigen NY-REN-61, and MESDC2, is a m... | |||
TMPY-01579 | GBA3 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
Cytosolic beta-glucosidase, also known as Cytosolic beta-glucosidase-like protein 1, GBA3, CBG and CBGL1 is a cytoplasm protein which belongs to theglycosyl hydrolase 1 family and Klotho subfamily. GBA3 / CBGL1 is a glyc... | |||
TMPJ-00082 | NGAL/Lipocalin-2 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
Lipocalin-2, also known as Neutrophil Gelatinase-Associated Lipocalin (NGAL), is a secretory protein of the lipocalin superfamily. Lipocalin-2 contains a signal peptide that enables it to be secreted and form complexes w... | |||
TMPJ-00741 | PTH Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Parathyroid hormone (PTH) is a critical hormone in the regulation of Ca++ homeostasis. Parathyroid hormone is the most important endocrine regulator of calcium and phosphorus concentration in extracellular fluid. This ho... | |||
TMPJ-00385 | CDH6 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Cadherin-6 (CDH6) is a type-II classic cadherin cell-cell adhesion molecules, which are expressed in graded or areal patterns, as well as layer-specific patterns, in the cortical plate. Human Cadherin-6 is synthesized as... | |||
TMPJ-00817 | HO-1 Protein, Human, Recombinant | Human | E. coli |
Heme Oxygenase 1 (HO-1) is an enzyme in endoplasmic reticulum that belongs to the heme oxygenase family. HO-1 cleaves the heme ring at the alpha methene bridge to form Biliverdin. Biliverdin is subsequently converted to ... | |||
TMPY-01616 | SULT2B1 Protein, Human, Recombinant (His) | Human | E. coli |
Sulfotransferase family cytosolic 2B member 1, also known as Sulfotransferase 2B1, ST2B1, Alcohol sulfotransferase, Hydroxysteroid sulfotransferase 2, SULT2B1 and HSST2, is a cytoplasm protein that belongs to the sulfotr... | |||
TMPY-01617 | SULT1B1 Protein, Human, Recombinant (His) | Human | E. coli |
Sulfotransferase family cytosolic 1B member 1, also known as Sulfotransferase 1B1, Sulfotransferase 1B2, Thyroid hormone sulfotransferase, SULT1B1 and ST1B2, is a cytoplasm protein that belongs to the sulfotransferase 1 ... | |||
TMPJ-00298 | CD36 Protein, Human, Recombinant (aa 27-432, His) | Human | HEK293 Cells |
Scavenger Receptor Class B Member 2 (SCARB2) is a type III multi-pass membrane glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes on all tissues and cell types so far examined. Earlie... | |||
TMPJ-00299 | LIMPII/SR-B2 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
Lysosome membrane protein II (LIMPII),also known as SCARB2, is a type III multi-pass membrane glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes on all tissues and cell types so far e... | |||
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カタログ番号 | 製品名 | ||
---|---|---|---|
L8700 | Ferroptosis Compound Library | 779 compounds | |
A unique collection of 779 ferroptosis signaling pathway related compounds, a powerful tool for new target identification, drug discovery, and mechanism study; |