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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T8575 | ENFENAMIC ACID | Platelet aggregation | |
Enfenamic acid is a platelet aggregation inhibitor and with antirheumatic. | |||
T79791 | Immunosuppressant-1 | Apoptosis | |
Immunosuppressant-1 (Compound 31) suppresses T-cell proliferation triggered by anti-CD3/anti-CD28 co-stimulation and demonstrates immunosuppressive effects, including the induction of apoptosis in activated lymph node ce... | |||
T25683 | Leucomyosuppressin | p-Glu-asp-val-asp-his-val-phe-leu-arg-phe-NH2 | |
Leucomyosuppressin, isolated from head extracts of the cockroach Leucophaea maderae, inhibits evoked transmitter release at the mealworm neuromuscular junction. | |||
TP2281 | P53 tumor suppressor fragment | Others | |
p53 tumor suppressor fragment (232-240) is a peptide with the sequence H2N-Lys-Tyr-Met-Cys-Asn-Ser-Ser-Cys-Met-OH, MW= 1066.3. p53 is a tumor suppressor protein that in humans is encoded by the TP53 gene. p53 is crucial ... | |||
T25862 | Neomyosuppressin | Thr-asp-val-asp-his-val-phe-leu-arg-phenh2,Dromyosuppressin,Neb-MS | |
Neomyosuppressin is a myoinhibiting neuropeptide isolated from the grey fleshfly, Neobellieria bullata and Drosophila. | |||
T5403 | ULK-101 | Autophagy | |
ULK-101 is a potent and selective ULK1 inhibitor ( IC50s: 8.3/30 nM for ULK1/ULK2). It can suppress autophagy. | |||
T21483 | Tricaine methanesulfonate | MS-222 | Others |
Tricaine methanesulfonate (MS-222) (TMS) is an anesthetic. Many hatcheries and research studies use TMS to immobilize fish for marking or transport and to suppress sensory systems during invasive procedures. | |||
T8951 | JTP 0819958 - HOIPIN-1 | IκB/IKK | |
JTP-0819958 is a selective linear ubiquitin chain assembly complex (LUBAC) inhibitor with an IC50 of 2.8 μM[1]. JTP-0819958 suppress LUBAC-mediated NF-kB activation in vitro[2]. | |||
T7556 | Fadrozole hydrochloride | CGS 16949A | Aromatase |
Fadrozole hydrochloride (CGS 16949A) is a model aromatase inhibitor that has been shown to suppress estrogen production in the ovaries of fish. | |||
T9765 | TJ-M2010-5 | MyD88 | |
TJ-M2010-5 is a MyD88 inhibitor that binds to the TIR domain to interfere with its homodimerization and suppress MyD88 signaling. TJ-M2010-5 can be used in myocardial ischemia/reperfusion injury studies. | |||
T8528 | AC1903 | TRP/TRPV Channel | |
AC1903 is a specific inhibitor of TRPC5 channel, and has been shown to suppress severe proteinuria and prevent podocyte loss. | |||
T21482 | Uniconazole | P450 , ROS Kinase | |
Uniconazole is a plant growth regulator that inhibit cytochrome P450 707As (Ki=68 nM). CYP707As is a major ABA catabolic enzyme that catabolize Abscisic acid, accordingly suppress gibberellin and sterol biosynthesis. | |||
T8736 | Cidofovir dihydrate | HPMPC,(S)-HPMPC,GS 0504 | Others |
Cidofovir dihydrate (HPMPC) is an anti-CMV drug, It can suppress CMV replication by selective inhibition of viral DNA polymerase and therefore prevention of viral replication and transcription. Cidofovir dihydrate is an ... | |||
T61392 | NLRP3-IN-10 | ZVN26391 | NOD |
NLRP3-IN-10 (ZVN26391) is a potent NLRP3 inhibitor. NLRP3-IN-10 inhibits IL-1β release with an IC50 value of 251.1 nM. NLRP3-IN-10 attenuates ASC speck formation, leading to suppress activation of NLRP3 inflammasome. | |||
T9939 | JMJD6 inhibitor WL12 | 2H-1-Benzopyran-2-one, 3-(3H-imidazo[4,5-c]pyridin-2-yl)-6-methyl-,ZINC6733033 | Others |
JMJD6 inhibitor WL12 (ZINC6733033) is a first-in-class JMJD6 inhibitor and was shown to be able to suppress JMJD6-dependent cancer cell proliferation including cervical and liver cancer cells, providing a small-molecule ... | |||
T11600 | IBR2 | Isoquinoline | DNA/RNA Synthesis |
IBR2 (Isoquinoline) is a potent and specific RAD51 inhibitor known for its ability to suppress RAD51-mediated DNA double-strand break repair. By interfering with RAD51 multimerization, accelerating proteasome-mediated RA... | |||
T67836 | AT-533 | HSP , HSV | |
AT-533 is a potent inhibitor of Hsp90 and HSV. AT-533 blocks the HIF-1α/VEGF/VEGFR-2 signaling pathway, leading to suppress tumor growth and angiogenesis. AT-533 also inhibits the activation of the downstream pathways, i... | |||
T36520 | COR659 | Cannabinoid Receptor , GABA Receptor | |
COR659 is a GABAB positive allosteric modulator (PAM) . COR659 suppresses alcohol and chocolate self-administration in rats[1]. COR659 apparently exerts its effects via a composite mechanism, including positive allosteri... | |||
T4206 | E6446 | TLR | |
E6446 inhibits Toll-like receptor (TLR)7 and 9 signaling. E6446 works in a variety of human and mouse cell types and inhibits DNA-TLR9 interaction in vitro. When administered to mice, this compound suppress responses to ... | |||
T38273 | Paclobutrazol | (2R,3R)-Paclobutrazol,(R,R)-paclobutrazol,2R,3R-Paclobutrazol | Antifungal |
Paclobutrazol ((R,R)-paclobutrazol) is a triazole-containing plant growth retardant that is known to inhibit the biosynthesis of gibberellins.1,2It also has antifungal activities.3PBZ, which is transported acropetally in... | |||
T9398 | NSC 73150 | NSC 97967 | Others |
6-methyl-2-[2-[(E)-(6-oxo-1-cyclohexa-2,4-dienylidene)methyl]hydraziny l]-1H-pyrimidin-4-one (NSC 73150) is a pyrimidine derivative with antitumor activity. Preclinical studies have shown that it inhibits the growth of a... | |||
T2527 | Ulipristal acetate | Ulipristal,CDB-2914 | Estrogen/progestogen Receptor , Progesterone Receptor , Autophagy |
Ulipristal acetate (CDB-2914) is an orally bioavailable, acetate salt of ulipristal, a selective progesterone receptor modulator with anti-progesterone activity. Ulipristal binds to the progesterone receptor (PR), thereb... | |||
T15096 | Delgocitinib | JTE-052,Corectim(Delgocitinib) | Tyrosine Kinases , JAK |
Delgocitinib (JTE-052) is a specific JAK (Janus kinase) inhibitor with IC50 values of 2.8, 2.6, 13, and 58 nM for JAK1, JAK2, JAK3, and Tyk2 respectively. Delgocitinib is involved in various inflammatory and autoimmune d... | |||
T1083L | Theophylline monohydrate | Quibron | HDAC , PDE , Adenosine Receptor |
Theophylline monohydrate (Quibron) appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize adenosine. Theophylline monohydrate is a ... | |||
T16538 | PIN1 inhibitor API-1 | Others | |
PIN1 inhibitor API-1 is a specific Pin1 inhibitor (IC50: 72.3 nM). PIN1 inhibitor API-1 retains the active conformation of pXPO5 and restores the ability of pXPO5 to transport pre-miRNAs from the nucleus to cytoplasm, th... | |||
T0983L | DL-Penicillamine | 3-Sulfanylvaline | Antibiotic |
DL-Penicillamine (3-Sulfanylvaline) is a chelating agent recommended for the removal of excess copper in patients with Wilson's disease. DL-Penicillamine is only found in individuals that have used or taken this drug. It... | |||
T26883 | BO 2367 | BO2367,BO-2367 | |
BO 2367, a topoisomerase inhibitor, is used to suppress the growth of tumor . | |||
T78613 | Selnoflast calcium | RO-7486967 calcium | NOD-like Receptor (NLR) |
Selnoflast calcium (example 6), an NLRP3 inhibitor[1], is a chemical compound designed to suppress the activity of the NLRP3 inflammasome. | |||
T30923 | CI-1018 | UNII-05127JZ9KQ | |
CI-1018 is a PDE IV inhibitor that is being developed as a drug to suppress inflammation. | |||
T23706 | Alminoprofen | EB382,EB 382,EB-382 | |
Alminoprofen is a nonsteroidal anti-inflammatory agent. It was found to significantly suppress passive anaphylactic bronchoconstrictions at 30 mg/kg given intraduodenally. | |||
T70926 | BRN-103 | ||
BRN-103 was found to suppress the VEGF-induced phosphorylation of VEGF receptor 2 (VEGR2) and the activations of AKT and eNOS. Taken together, these results suggest that BRN-103 inhibits VEGF-mediated angiogenesis signal... | |||
T39444 | Upacicalcet sodium | ||
Upacicalcet (sodium) is an intravenous calcimimetic agent that acts directly on parathyroid cell membrane calcium-sensing receptors to suppress excessive parathyroid hormone (PTH) secretion, thereby lowering blood PTH le... | |||
T23697 | AL-8417 | J1.090.276B,AL8417,(2R)-AL-5898 | |
AL-8417 is an enzyme inhibitor. It acting as an antioxidant, anti-inflammatory, and cytostatic agent. It also has the ability to suppress vitrectomy-induced posterior lens fiber changes. | |||
T69546 | MP-135 | ||
MP135 is a Novel μ−δ Opioid Receptor Heteromer-Selective Agonist. MP135 maintains untoward side effects such as respiratory depression and reward behavior; together, these results suggest that optimization of MP135 is ne... | |||
T37225 | (±)7(8)-DiHDPA | ||
(±)7(8)-DiHDPA is a major metabolite of docosahexaenoic acid that is produced via oxidation by cytochrome P450 epoxygenases. Epoxygenase metabolites of DHA, including (±)7(8)-DiHDPA, suppress aggregation and thromboxane ... | |||
T68884 | Aplysin | ||
Aplysin is an antineoplastic agent. Aplysin has been shown to suppress breast cancer cell activity via inhibition of the PI3K/AKT/FOXO3a pathway. Aplysin has also been shown to protect hepatocytes against oxidative dama... | |||
T28296 | Parogrelil hydrochloride | INDI-702,NM-702,NT-702,NM702,INDI702 | |
Parogrelil is a phosphodiesterase (PDE3/PDE5A) inhibitor potentially for the treatment of intermittent. Parogrelil suppress the asthmatic response in guinea pigs, with both bronchodilating and anti-inflammatory effects. ... | |||
T61679 | Abacavir monosulfate | ||
Abacavir monosulfate is an orally active, competitive nucleoside reverse transcriptase inhibitor that effectively inhibits HIV replication. Additionally, it exhibits anticancer properties in prostate cancer cell lines, a... | |||
T73994 | Nedosiran sodium | ||
Nedosiran sodium, a GalNAc-dsRNA conjugate, is engineered to suppress the synthesis of the hepatic lactate dehydrogenase (LDH) enzyme. | |||
T36927 | Hydrocortisone phosphate | ||
Hydrocortisone phosphate is the pharmaceutical term for cortisol, which is a steroid hormone, in the glucocorticoid class of hormones, increases blood sugar through gluconeogenesis, to suppress the immune system, and to ... | |||
T29161 | STOCK2S-26016 | WNK IN B,WNK-IN-B,Compound B | |
WNK-IN-B is an inhibitor of Wnk signalling. WNK-IN-B is a cell-permeable diaminoacridine derivative that targets the CCT domain of SPAK and OSR1 via reversible binding. WNK-IN-B selectively suppress hypotonic shock-induc... | |||
T69557 | ABI-231 HCl | ||
ABI-231 is a potent, orally bioavailable tubulin inhibitor that interacts with the colchicine binding site and is currently undergoing clinical trials for prostate cancer. ABI-231, has an average IC50 = 5.2 nM against pa... | |||
T82645 | Cyclic PSAP peptide | ||
Cyclic PSAP peptide (DWLPK) possesses properties akin to those of a therapeutic agent, demonstrating the potential to inhibit metastasis and suppress tumor growth in vivo [1]. | |||
T37216 | N-Arachidonoyl-L-Alanine | ||
Several different arachidonoyl amino acids, including N-arachidonoyl-L-alanine (NALA), have been isolated and characterized from bovine brain. The glycine congener (NAGly) was further characterized and found to suppress ... | |||
T68869 | TP-110 | ||
TP-110 is a new proteasome inhibitor, which shows potent growth inhibition in various tumor cell lines. Treatment with TP-110 for 24 h in vitro induced apoptosis in multiple myeloma cell line RPMI8226. TP-110 reduced the... | |||
T81625 | Obestatin(human) TFA | ||
Obestatin(human) TFA, an endogenous peptide originating from the same prepropeptide as ghrelin, is known to suppress food intake and reduce weight gain in rats. | |||
T78073 | HP210 | Glucocorticoid Receptor | |
HP210, a selective glucocorticoid receptor modulator (SGRM), can suppress IL-1β and IL-6 mRNA expression, suggesting its utility in investigating inflammation-related diseases [1]. | |||
T78574 | EGFR-IN-85 | EGFR | |
EGFR-IN-85 (Compound 1), an EGFR inhibitor, exhibits potent activity with an IC50 of 0.19 μM against EGFRvⅢ phosphorylation and can suppress intratumoral EGFR signaling. It is utilized in Glioblastoma (GBM) research [1]. | |||
T81243 | RXFP1 receptor agonist-4 | ||
RXFP1 receptor agonist-4 (Example 268) is an agonist for the RXFP1 receptor, demonstrated to suppress cAMP production in HEK293 cells that stably express the human RXFP1 receptor, exhibiting an effective concentration (E... | |||
T64140 | RORγt agonist 2 | ||
RORγt agonist 2 is a potent agonist of RORγt. RORγt agonist 2 induces Th17 cell differentiation, increases levels of pro-inflammatory cytokines and thus enhances lymphocyte cytotoxicity. rorγt agonist 2 exhibits an inhib... |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
TN2197 | Secoisolariciresinol | TNF | |
Secoisolariciresinol is an enterolignan precursor, it has antioxidant, and estrogen-like activities, it can significantly suppress triglyceride (TG) accumulation in 3T3-L1 adipocytes. | |||
T5802 | Stearyl glycyrrhetinate | Antiviral , Antibacterial | |
Stearyl glycyrrhetinate, the stearyl ester of 18-β-glycyrrhetinic acid, has been demonstrated to improve antiviral effects, reduce inflammation and suppress allergies in the pharmaceutical and cosmetic industry. | |||
T13522 | 7-Ketolithocholic acid | 3α-Hydroxy-7-oxo-5β-cholanic acid | Endogenous Metabolite |
7-Ketolithocholic acid (3α-Hydroxy-7-oxo-5β-cholanic acid) (3α-Hydroxy-7-oxo-5β-cholanic acid) is capable of absorption and serves to suppress the production of endogenous bile acid and the secretion of biliary cholester... | |||
TN1839 | Kumatakenin | Jaranol,Kaempferol 3,7-O-dimethyl ether | Apoptosis , Anti-infection |
Kumatakenin can suppress >80% of the SOS-inducing activity of Trp-P-1 at <0.06 micromol/mL. | |||
TN3967 | Epieriocalyxin A | ERK , BCL , ROS , Caspase , DNA/RNA Synthesis , JNK | |
Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future. | |||
T4732 | L-Carnosine | Karnozin,beta-Alanyl-L-histidine | Antioxidant , Endogenous Metabolite |
L-Carnosine (Karnozin) is is an antioxidant naturally found in skeletal muscle, brain tissue. It has the potential to suppress many of the biochemical changes that accompany aging. | |||
T3391 | Corosolic acid | Corsolic acid,2α-Hydroxyursolic acid,Glucosol,Colosolic acid,Colosic acid | FAK , Autophagy |
Corosolic acid (Colosic acid) contains anti-angiogenic activity that can suppress FAK signaling induced by angiopoietin-1. Corosolic acid exerts anticancer activities against HCC, colon, and colorectal Y cells, by induci... | |||
TN1046 | Murrayone | Others | |
Murrayone, a coumarin-containing compound derived from M. paniculata, stands out as the most bioactive substance within this species, primarily due to its unique pharmacological attributes that notably suppress cancer me... | |||
TN1334 | 7-Methoxyrosmanol | 7-O-Methylrosmanol | cAMP |
7-Methoxyrosmanol (7-O-Methylrosmanol) can effectively suppress FSK-induced luciferase expression under the control of the CRE, PEPCK-C and G6Pase gene promoters, it may contribute to its antihyperglycemic activity. | |||
T3869 | Skimmin | Skimmine | Others |
Skimmin (Skimmine) has anti-inflammatory activity, can significantly improve renal function and suppress the IgG deposition as well as the development of glomerular lesions in a rat model of membranous glomerulonephritis... | |||
T5660 | Menthone | IL Receptor , TNF , NF-κB , Parasite | |
Menthone has anti-inflammary activity,, it can suppress the lipopolysaccharide (LPS)-induced proinflammatory cytokines, interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha),as well as nuclear factor k... | |||
T2759 | Loganin | Loganoside | Apoptosis , NF-κB , BACE , AChR , AChE |
Loganin (Loganoside), an iridoid glucoside, has been reported to be an inhibitor of Cox-1 and also noted to suppress TNF-α formation. This compound also has displayed potent free-radical-scavenging activity and inhibitor... | |||
T3S0335 | Soyasaponin Bb | Soyasaponin I | NF-κB , Caspase |
1. Soyasaponin Bb (Soyasaponin I) can suppress Eca-976 cell growth, reverse effects on over expression of c-met, VEGF, and induce cell apoptosis through inhibiting HDAC1-NF-kappaB and activating PETEN and caspase-3 signa... | |||
T21344 | 1-Deoxynojirimycin hydrochloride | Moranoline,AT2220,Duvoglustat hydrochloride,1-Deoxynojirimycin,DNJ,deoxynojirimycin | PI3K , Antibacterial , Antibiotic , Glucosidase |
1-Deoxynojirimycin hydrochloride (Moranoline) is a potent and selective inhibitor of alpha-glucosidase, most commonly found in mulberry leaves. Duvoglustat is used to suppress the elevation of postprandial hyperglycemia. | |||
TN1011 | Rhodionin | P450 , AChE | |
Rhodionin and rhodionin can inhibit cytochrome P450 2D6 non-competitively with high specificity which could have implications for interactions with co-administered drugs; they can significantly suppress the elevation of ... | |||
T2897 | (Rac)-Shikonin | (±)-Shikonin,Alkanet extract,Anchusin,Anchusa acid | Others |
(Rac)-Shikonin (Anchusin) is a natural red naphthoquinone pigment, has antimicrobial, anti-tumor, and anti-inflammatory effects; a purified shikonin preparation is widely used for the production of medicinals, cosmetics,... | |||
T3876 | Loureirin B | PAI-1 , ERK , Potassium Channel , JNK | |
Loureirin B can downregulate the expression of fibrosis-related molecules by regulating MMPs and TIMPs levels, inhibit scar fibroblast proliferation and suppress TGF-β1-induced fibrosis, during which TGF-β1/Smad2/3 pathw... | |||
T5814 | Aurantiamide | TMC-58B | p38 MAPK , NF-κB |
Aurantiamide has anti-cancer, anti-inflammatory and antinociceptive activities, it may suppress the growth of malignant gliomas by blocking autophagic flux.Aurantiamide has an anti-neuroinflammatory effect on LPS stimula... | |||
TN2091 | Polygalacin D | Apoptosis , IAP | |
Polygalacin D shows anti- proliferation, anti-inflammary, and hepatoprotective activities, it can inhibit the expression of lipopolysaccharide (LPS)-induced iNOS and COX-2 protein and mRNA without an appreciable cytotoxi... | |||
T3877 | Esculentoside A | NF-κB , COX | |
Esculentoside A can suppress inflammatory responses in LPS-induced ALI through inhibition of the NF-κB and mitogen-activated protein kinase signaling pathways. Esculentoside A may be useful for the treatment of autoimmun... | |||
T6429 | Caffeic Acid Phenethyl Ester | Phenylethyl Caffeate,CAPE | Apoptosis , NF-κB |
Caffeic Acid Phenethyl Ester (Phenylethyl Caffeate) (CAPE) inhibits the activation of nuclear transcription factor NF-kappa B and may suppress p70S6K and Akt-driven signaling pathways, with antineoplastic, cytoprotective... | |||
TMS1461 | Qingyangshengenin B | Otophylloside B | Beta Amyloid |
Qingyangshengenin B (Otophylloside B) is a C-21 steroidal glycoside isolated from Qingyangshen. Qingyangshengenin B protects against Aβ toxicity, which decreases Aβ deposition by decreasing the expression of Aβ at the mR... | |||
T4958 | (-)-Alkannin | Alkannin,Shikonin | Apoptosis , PI3K |
(-)-Alkannin (Shikonin) is a natural red naphthoquinone pigment, has antimicrobial, anti-tumor, and anti-inflammatory effects; a purified shikonin preparation is widely used for the production of medicinals, cosmetics, a... | |||
T6S1784 | Brazilin | Natural Red 24,Braziletto,Brasilin,Superbresiline | Apoptosis , Others , AMPK , Autophagy |
1. Brazilin (Braziletto) exhibits anti-hepatotoxic, antiplatelet effects. 2. Brazilin has cancer preventive effect, may inhibit T24 cell growth and trigger cell death through a c-Fos-mediated and tumor cell specific sign... | |||
TN2601 | 12-O-Methylcarnosic acid | Reductase | |
12-O-Methylcarnosic acid is a diterpene carnosic acid isolated from Salvia microphylla, is an active constituent of 5α-Reductase inhibition with an IC50 value of 61.7 μM. 12-O-Methylcarnosic acid has Antioxidant activity... | |||
T5S2357 | Acetylcorynoline | (+)-Corynoline Acetate,O-Acetylcorynoline | Antifungal |
1. Acetylcorynoline (O-Acetylcorynoline) has antifungal、anti-inflammatory activity. 2. Acetylcorynoline may be one of the potent immunosuppressive agents through the blockage of dendritic cells maturation and function. 3... | |||
T6S1699 | Shogaol | [6]-Shogaol,6-Shogaol | Lipoxygenase , Autophagy |
1. 6-Shogaol (6-Shogaol) has antipyretic and analgesic effects in addition to inhibitory effect on lipoxygenase activity. 2. 6-shogaol has anti-inflammatory property, reduces the inflammatory response and protected the f... | |||
T20604 | Litorin | ||
Litorin, an amphibian bombesin peptide derivative, is found to suppress the nutriment, to stimulate the contraction of smooth muscle, to stimulate gastrin, gastric acid, and pancreatic secretion. | |||
TN4552 | Methyl p-hydroxyphenyllactate | Others | |
Methyl para-hydroxyphenyllactate(MeHPLA) can suppress the cellular proliferation of estrogen-sensitive MCF-7 breast cancer cells in vitro and to suppress the growth of rat uteri in vivo, high affinity of MeHPLA for the t... | |||
TN5681 | Cypellocarpin C | Camaldulenside | |
Cypellocarpin C shows potent in vitro antitumor-promoting activity, it also can suppress an in vivo two-stage carcinogenesis induced with nitric oxide and TPA on mouse skin. | |||
TN2507 | 1,6,7-Trihydroxyxanthone | DNA/RNA Synthesis | |
1,6,7-Trihydroxyxanthone has anti-cancer activity ,at least in part, through the activation of miR-218 and suppression of Bmi-1 expression; can suppress cell growth and induce apoptosis in liver cancer cells. | |||
T3490 | Alpha-(3,4-Dihydroxyphenyl)lactic acid | Antioxidant | |
Danshensu has antioxidant activity, can enhance HO-1 expression to suppress 6-OHDA-induced oxidative damage via PI3K/Akt/Nrf2 signaling pathways. | |||
TN3899 | Drupacine | Others | |
Drupacine and a crude alkaloid extract suppress nematode hatch, activity of mixed life stages, and population numbers on plant roots. | |||
TN4722 | Otophylloside F | Others | |
Otophylloside F can suppress the seizure-like locomotor activity caused by pentylenetetrazole in zebrafish. | |||
TN5105 | Taxagifine | Others | |
Taxagifine shows cytotoxic activity toward HepG2 cells; it can suppress the superoxide generation induced by N-formyl-methionyl-leucyl-phenylalanine (fMLP) and arachidonic acid (AA) in a concentration-dependent manner. | |||
TN4909 | (+)-Rhododendrol | Others | |
(+)-Rhododendrol shows anti-inflammatory effects, it can suppress the NO production by activated macrophages in vivo. | |||
TN2417 | Furomollugin | Antifection | |
Furomollugin has antiviral activity, it can strongly suppress the secretion of hepatitis B surface antigen (HBsAg), with IC50 = 2.0 micrograms/mL, in human hepatoma Hep3B cells. | |||
TN2134 | Raddeanoside 20 | Others | |
Raddeanoside 20 can slightly suppress the superoxide generation induced by N-formyl-methionyl-leucyl-phenylalanine (fMLP) in a concentration dependent manner. | |||
T3S0541 | Curzerene | Apoptosis , GST | |
Curzerene, a sesquiterpene compound derived from the rhizome of Curculigo orchioides Gaertn, possesses potent anti-cancer properties. It is known to induce apoptosis in cells[1] and also suppress the expression of glutat... | |||
TN3691 | Communic acid | MMP , MAPK , Akt , PI3K , DNA/RNA Synthesis , Antifection | |
Communic acid has antibacterial activity, including against mycobacterial. trans-Communic acid has potential to be utilized as anti-wrinkling agents and cosmetic ingredients, as they suppress UVB-induced MMP-1 expression... | |||
TN4392 | Koaburaside | IL Receptor , TNF , Influenza Virus | |
Koaburaside exhibits antioxidant activity with an IC50 value of 9.0μM, it shows weak inhibitory activity against influenza A neuraminidase. Koaburaside may have anti-allergic inflammatory activity, it can suppress histam... | |||
TN4387 | Khellactone | Antifection | |
Khellactone shows antitumor activity,it can suppress the growth of NCI-H460 tumor cells. (+)-4'-cis-Khellactone and (+)-3'-cis-khellactone have antiplasmodial activities, they show notable inhibitory activity against -se... | |||
TN5104 | Taxacin | Others | |
Taxacin shows strong inhibitory effects on platelet aggregation induced by arachidonic acid (IC(50):21.9 microM). Taxacin can suppress the superoxide generation induced by N-formyl-methionyl-leucyl-phenylalanine (fMLP) a... | |||
TN1212 | 2-Hydroxyeupatolide | Others , TNF , NF-κB | |
2-Hydroxyeupatolide has anti-inflammatory activity,it may suppress the inflammatory response through inhibiting the activation of NF-κB signaling pathways, and make a contribution to further understanding the pharmaceuti... | |||
TN3541 | Broussonin E | ERK , p38 MAPK , TNF , JAK , STAT | |
Broussonin E could suppress inflammation by modulating macrophages activation state via inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathway, and can be further developed as a promising drug for the... | |||
TN1875 | Liriodenine | BCL , Caspase , p53 | |
Liriodenine is a potent inhibitor of topoisomerase II (EC 5.99.1.3) both in vivo and in vitro, it has antitumor, antibacterial and antifungal activities, it can suppress ventricular arrhythmias induced by myocardial isch... | |||
TN5238 | Viscidulin II | IL Receptor , TNF | |
Viscidulin II can be potential therapeutic agents against P. acnes-induced skin inflammation, it can significantly suppress P. acnes-induced IL-8 and IL-1β production in THP-1 cells, concomitant intradermal injection of ... | |||
TN5050 | Sprengerinin C | NADPH-oxidase , VEGFR , p38 MAPK , ROS , Akt , PI3K , mTOR , p53 | |
Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis, it can strongly suppress tumor angiogenesis in human umbilical vein ... | |||
TN5248 | Voleneol | NOS , COX , Prostaglandin Receptor | |
1β,6α-Dihydroxyeudesm-4(15)-ene (Voleneol,DE) can attenuate the lipopolysaccharide (LPS)-induced inflammation in BV2 microglial cells, it also can dose-dependently suppress the protein expression of inducible nitric oxid... | |||
TN4819 | (-)-Praeruptorin A | ATPase , IL Receptor , Calcium Channel , P-gp | |
(-)-Praeruptorin A has anti-inflammatory, anti-contractile and anti-hyperplasia activities, it exerts distinct relaxant effects on isolated rat aorta rings dependent on endothelium and nitric oxide synthesis;it also can ... | |||
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カタログ番号 | 製品名 | Species | Expression System |
---|---|---|---|
TMPK-00782 | PLAU/uPA Protein, Mouse, Recombinant (His & Avi) | Mouse | HEK293 Cells |
Plasminogen activator, urokinase (uPA) is a secreted serine protease whose Dysregulation is often accompanied by various cancers. PLAU inhibition could suppress tumor growth. Collectively, PLAU is necessary for tumor pro... | |||
TMPJ-00258 | TGF beta 2 Protein, Human, Recombinant | Human | HEK293 Cells |
Transforming growth factor beta-2 (TGF-β2) is a secreted protein which belongs to the TGF-beta family. It is known as a cytokine that performs many cellular functions and has a vital role during embryonic development. T... | |||
TMPH-02519 | API5 Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently supp... | |||
TMPH-00298 | Resistin Protein, Bovine, Recombinant (His) | Bovine | E. coli |
Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. Potentially links obesity to diabetes. Resistin Protein, Bovine, Recombinant (His) is expressed in E. coli expression system ... | |||
TMPJ-00561 | SDC2 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Syndecan-2 is a member of the Syndecans family comprised of type I transmembrane heparan sulfate proteoglycans (HSPG) that are involved in the regulation of many cellular processes. Four sub-types of mammalian Syndecans ... | |||
TMPK-00165 | IL-2 R alpha/CD25 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells |
Human IL-2 receptor alpha (IL-2 R alpha), also known as Tac antigen and as CD25, was initially identified as a 55 kDa membrane glycoprotein that is capable of binding IL‑2.eceptor for interleukin-2. The receptor is invol... | |||
TMPY-04920 | ICA Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
INHCA, official full name is inhibitor of carbonic anhydrase, which is a member of the transferrin gene family. Unlike many members of that gene family it does not play a significant role in iron homeostasis but rather i... | |||
TMPK-00539 | PLAU/uPA Protein (active form), Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
Plasminogen activator, urokinase (uPA) is a secreted serine protease whose Dysregulation is often accompanied by various cancers. PLAU inhibition could suppress tumor growth. Collectively, PLAU is necessary for tumor pro... | |||
TMPK-00783 | PLAU/uPA Protein, Mouse, Recombinant (His & Avi), Biotinylated | Mouse | HEK293 Cells |
Plasminogen activator, urokinase (uPA) is a secreted serine protease whose Dysregulation is often accompanied by various cancers. PLAU inhibition could suppress tumor growth. Collectively, PLAU is necessary for tumor pro... | |||
TMPK-00274 | PLAU/uPA Protein (active form), Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells |
Plasminogen activator, urokinase (uPA) is a secreted serine protease whose Dysregulation is often accompanied by various cancers. PLAU inhibition could suppress tumor growth. Collectively, PLAU is necessary for tumor pro... | |||
TMPH-02228 | TRA2B Protein, Human, Recombinant (His & Myc) | Human | Baculovirus Insect Cells |
Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor ne... | |||
TMPK-00188 | JAM-A Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
junctional adhesion molecule A (JAM-A), a cell adhesion molecule, is highly elevated in human GBM cancer stem cells and predicts poor patient prognosis. While JAM-A is also highly expressed in other cells in the tumor mi... | |||
TMPY-04170 | DEFB1 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
The DEFB1 gene, encoding for the constitutively expressed human beta-defensin 1 (hBD1) antimicrobial peptide is a potential candidate when studying genetic susceptibility to caries. DEFB1 genetic variations have been rep... | |||
TMPK-00164 | IL-2 R alpha/CD25 Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells |
Human IL-2 receptor alpha (IL-2 R alpha), also known as Tac antigen and as CD25, was initially identified as a 55 kDa membrane glycoprotein that is capable of binding IL‑2.eceptor for interleukin-2. The receptor is invol... | |||
TMPJ-00364 | LRRC32 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Leucine Rich Repeat Containing 32 (LRRC32), also known as Glycoprotein A Repetitions Predominant (GARP), has been postulated as a novel surface marker of activated T(regs). LRRC32 binds directly to the TGF-beta latency a... | |||
TMPY-04084 | ANGPTL1 Protein, Canine, Recombinant (hFc) | Canine | HEK293 Cells |
Angiopoietin-like protein 1 (ANGPTL1) has been reported to suppress migration and invasion in lung and breast cancer, acting as a novel tumor suppressor candidate. Downregulation of tumor suppressor signaling plays an im... | |||
TMPH-02229 | TRA2B Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor ne... | |||
TMPY-03063 | SLITRK6 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
SLITRK6 belongs to the SLITRK family. Members of this family share two conserved leucine-rich repeat domains in the extracellular domain. SLITRK6 contains 11 LRR (leucine-rich) repeats, 2 LRRCT domains and 2 LRRNT domain... | |||
TMPJ-00713 | GDF-11 Protein, Human, Recombinant | Human | HEK293 Cells |
Growth/differentiation factor 11(GDF-11) is a secreted protein, which belongs to the transforming growth factor beta superfamily. GDF-11 controls anterior-posterior patterning by regulating the expression of Hox genes. ... | |||
TMPY-00176 | FNDC4 Protein, Human, Recombinant (mFc) | Human | HEK293 Cells |
FNDC4 acts as an anti-inflammatory factor on macrophages and improves mouse model of induced colitis. FNDC4 could suppress osteoclast formation via NF-kappaB pathway and downregulation of CXCL10. Analysis of binding of F... | |||
TMPJ-01237 | IL-17D Protein, Human, Recombinant | Human | E. coli |
The Interleukin-17 family proteins, comprising six members (IL-17, IL-17B through IL-17F),are secreted, structurally related proteins that share a conserved cysteine-knot fold near the C-terminus, but have considerable s... | |||
TMPJ-01425 | SARS-CoV-2 NSP1 Protein (His) | SARS-CoV-2 | E. coli |
The Severe Acute Respiratory Syndrome (SARS) Coronavirus (CoV) is an enveloped, positive-stranded RNA viruses that can cause a severe respiratory disease. Its genome consists of a ∼30 kb linear, non-segmented, capped, po... | |||
TMPJ-00014 | Resistin Protein, Human, Recombinant (His) | Human | E. coli |
Resistin known as adipose tissue-specific secretory factor (ADSF) or C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein (XCP1) that seems to suppress insulin ability to stimulate glucose uptake into ... | |||
TMPY-02949 | AP2 Gamma/TFAP2C Protein, Human, Recombinant (His) | Human | E. coli |
TFAP2C, also known as AP2-GAMMA, is a member of the activating protein 2 family of transcription factors. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of imp... | |||
TMPY-04417 | DAPK1 Protein, Human, Recombinant (aa 1-363, His & GST) | Human | Baculovirus Insect Cells |
Death-associated protein kinase 1, also known as DAP kinase 1, DAPK1 and DAPK, is a cytoplasm protein which belongs to theprotein kinase superfamily, CAMK Ser / Thr protein kinase family and DAP kinase subfamily. DAPK... | |||
TMPH-02526 | Arginase-2/ARG2 Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli |
May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synth... | |||
TMPJ-01432 | CA125/MUC16 Protein, Human, Recombinant (hFc & AVI), Biotinylated | Human | HEK293 Cells |
MUC16, also known as the CA125 antigen, is a mucin protein that may be found in type I transmembrane or secreted forms that are used monitor the progress of epithelial ovarian cancer therapy. MUC16 is over-expressed by t... | |||
TMPJ-00831 | CCL3 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
C-C Motif Chemokine 3 (MIP-1 alpha,CCL3 ) is a member of the beta or CC subfamily of chemokines and is closely related to CCL4/MIP-1 beta. CCL3 expression can be induced in a variety of hematopoietic cells, fibroblasts, ... | |||
TMPY-02122 | IFNGR2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Interferon-gamma receptor beta chain (IFNgammaR2), also known as IFNGR2, belongs to the type II cytokine receptor family, whose deficiency is a cause of autosomal recessive mendelian susceptibility to mycobacterial disea... | |||
TMPH-01526 | KMT2E Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4'... | |||
TMPY-04554 | JNK1 Protein, Human, Recombinant (GST) | Human | Baculovirus Insect Cells |
Mitogen-activated protein kinase 8 (MAPK8), also known as JNK1, is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals and are involved in a wide variety of cellula... | |||
TMPH-01503 | Humanin Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Plays a role as a neuroprotective factor. Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease. Mediates its neuroprotective e... | |||
TMPH-01502 | Humanin Protein, Human, Recombinant (GST) | Human | E. coli |
Plays a role as a neuroprotective factor. Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease. Mediates its neuroprotective e... |
カタログ番号 | 製品名 | ||
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L6710 | Anti-Inflammatory Traditional Chinese Medicine Compound Library | 1246 compounds | |
A collection of 1246 TCM monomers with anti-inflammatory activity or targeting molecular therapeutic targets in inflammation, a powerful tool for drug discovery and mechanism study; | |||
L6720 | Anti-COVID-19 Traditional Chinese Medicine Compound Library | 1147 compounds | |
A unique collection of 1147 monomers from 60 TCM plants, a powerful tool for anti-COVID-19 drug discovery, can be used for HTS and HCS screening; | |||
L2170 | Immuno-Oncology Compound Library | 449 compounds | |
A unique collection of 449 compounds acting on immune-oncology therapeutic targets can be used for high throughput and high content screening; |