| T3875 |
CLINODISIDE A
|
|
Others
|
|
Clinodiside A in rats with one compartment open model into the body, rapid distribution, elimination rate. |
| T13903 |
Stearoylethanolamide
|
N-(2-Hydroxyethyl)octadecanamide |
Apoptosis
|
|
Stearoylethanolamide(N-(2-Hydroxyethyl)octadecanamide) is a cannabinoid compound present in the brains of humans, rats, and mice with pro-apoptotic activity. |
| T5352 |
GLYCODEOXYCHOLIC ACID
|
|
Others
,
Endogenous Metabolite
|
|
Glycodeoxycholic Acid is a bile acid that induces severe pancreatitis in rats. It can induce the apoptosis of SMMC-7721 cells. |
| T3697 |
3',6-Disinapoylsucrose
|
Disinapoyl sucrose,3,6'-Disinapoyl sucrose |
BCL
,
Epigenetic Reader Domain
|
|
3',6-Disinapoylsucrose (Disinapoyl sucrose) shows the neuroprotective effect and antidepressive activity in rats. |
| TN3651 |
Cichoriin
|
|
Others
|
|
Cichoriin is a photosensitive compound, it could be used as herbal photosensitizing agent in treating benign breast tumor in rats. |
| TN7217 |
4,6-Benzilidine-D-Glucose
|
|
|
|
4,6-Benzilidine-D-Glucose is a clinical antitumor compound showing antitumor activity in rats with chemically induced hepatocellular carcinoma. |
| T2793 |
Tetrahydropalmatine
|
DL-Tetrahydropalmatine,Rotundine |
Apoptosis
,
Others
,
Dopamine Receptor
|
|
Tetrahydropalmatine (DL-Tetrahydropalmatine) is an active component isolated from corydalis, suppressing amygdaloid release of dopamine to inhibit an epileptic attack in rats. |
| T7912 |
(−)-Myrtenal
|
(1R)-(−)-Myrtenal |
Others
|
|
(−)-Myrtenal ameliorates hyperglycemia by enhancing GLUT2 through Akt in the skeletal muscle and liver of diabetic rats. |
| T2805 |
Chlorogenic Acid
|
NSC-407296,3-O-Caffeoylquinic acid,Heriguard |
Others
,
Influenza Virus
,
Reactive Oxygen Species
,
HIF/HIF Prolyl-Hydroxylase
,
Endogenous Metabolite
,
Antibacterial
|
|
Chlorogenic Acid (NSC-407296) is a naturally occurring phenolic acid which is a carcinogenic inhibitor. It has also been shown to prevent paraquat-induced oxidative stress in rats. |
| TN6764 |
Simmondsin
|
|
Others
|
|
Simmondsin is a natural product from Simmondsia chinensis -- jojoba. It reduced food intake and body weight without apparent negative effects in rats. |
| T2750 |
Ginkgolide C
|
BN-52022 |
MMP
,
Sirtuin
,
Endogenous Metabolite
,
AMPK
|
|
Ginkgolide C (BN-52022), a natural product, can enhance the cardiac function of rats in the body. |
| T4S0176 |
Alnustone
|
(4E,6E)-1,7-Diphenyl-4,6-heptadien-3-one |
Others
|
|
Alnustone ((4E,6E)-1,7-Diphenyl-4,6-heptadien-3-one) exerts significant anti-inflammatory activity in the assay of carrageenin-induced hind paw edema in rats. |
| T6S1294 |
Nicotiflorin
|
Nictoflorin,Kaempferol-3-O-Rutinoside,Nicotifloroside |
Others
|
|
1. Nicotiflorin (Kaempferol-3-O-Rutinoside) has potential therapeutic effects on cerebral ischemic illness. 2. Nicotiflorin has protective effects on reducing memory dysfunction, energy metabolism failure and oxidative s... |
| T5781 |
Taraxasteryl acetate
|
|
Antibacterial
|
|
Taraxasterol acetate has anti-inflammatory activity in bino rats against carrageenan, formaldehyde and adjuvant induced inflammations. Taraxasterol acetate also displays potential antibacterial activities. |
| T5S2178 |
Fargesin
|
(+/-)-Fargesin |
Adrenergic Receptor
|
|
1. Fargesin ((+/-)-Fargesin) as a potential β1AR antagonist through cAMP/PKA pathway could protect against myocardial ischemia/reperfusion injury in rats. 2. Fargesin improves dyslipidemia and hyperglycemia by activating... |
| TJS0928 |
Calenduloside E
|
Silphioside F |
Others
|
|
Calenduloside E (Silphioside F) exhibits hypoglycemic activities by suppressing the transfer of glucose from the stomach to the small intestine and by inhibiting glucose transport at the brush border of the small intesti... |
| TN1238 |
3,4-O-Isopropylidene-shikimic acid
|
3,4-O-Isopropylidene shikimic acid |
NOS
,
NO Synthase
|
|
3,4-O-Isopropylidene-shikimic acid (3,4-O-Isopropylidene shikimic acid) has significant anti-inflammatory, anti-thrombosis, antioxidant, analgesic effects, it has protective effects on experimental colitis induced by tri... |
| T3804 |
Neomangiferin
|
Mangiferin 7-glucoside |
Phosphatase
|
|
Neomangiferin (Mangiferin 7-glucoside) has beneficial effects on high fat diet-induced nonalcoholic fatty liver disease in rats. Neomangiferin and mangiferin inhibit tartrate-resistant acid phosphatase, a biochemical mar... |
| T0632 |
3,4,5-Trimethoxybenzoic acid
|
Gallic acid trimethyl ether,Eudesmic acid,Trimethylgallic Acid,Benzoic acid,Tri-O-methylgallic acid |
Antioxidant
|
|
3,4,5-Trimethoxybenzoic acid (Gallic acid trimethyl ether) are potent antioxidants and inhibitor of cytokine production. It can ameliorate chronic stress-induced various behavioral and biochemical alterations in mice. It... |
| T3753 |
Sinapinic Acid
|
Sinapic acid,Synapoic acid |
Apoptosis
,
RAAS
,
Reactive Oxygen Species
,
HDAC
|
|
Sinapinic Acid (Synapoic acid) protects the rat liver from CCl4-induced inflammation, most likely by acting as a free radical scavenger and modulator of NF-κB p65 activation and proinflammatory cytokine expression. Sinap... |
| T7050 |
Alpha-Tocopherolquinone
|
Metarene |
Antioxidant
|
|
During hypoxia in rats, levels of α-tocopherylquinon have been found to rise. alpha-Tocopherolquinone (Metarene) is reported to downregulate the respiratory activity of mitochondria. alpha-Tocopherolquinone has also disp... |
| T20754 |
Deltamethrin
|
Butoss,RU-22974,Esbecythrin,K-Othrin,Decamethrin,RU 22974 |
Others
|
|
Deltamethrin (RU 22974), a neurotoxic pyrethroid insecticide, produces a reversible sequence of motor symptoms in rats involving hind limb rigidity and choreoathetosis.Deltamethrin is globally used in crop protection, co... |
| T37152 |
3-Methyl-2-cyclopenten-1-one
|
|
Endogenous Metabolite
|
|
3-Methyl-2-cyclopenten-1-one can be used as a food additive to improve the flavor of meat and meat products at 2-5 ppm. Addition of 3-Methyl-2-cyclopenten-1-one showed gastric cytoprotective activity when administered or... |
| T2946 |
Tanshinone IIA sulfonate sodium
|
Tanshinone IIA sulfonate,Sodium Tanshinone IIA sulfonate,Tanshinone IIA sodium sulfonate,sodium |
CaMK
,
P450
,
Calcium Channel
|
|
Tanshinone IIA sulfonate sodium (Tanshinone IIA sodium sulfonate) is a water-soluble derivative of tanshinone IIA extracted from Savia miltiorrhiza; a potent negative allosteric modulator of the human purinergic receptor... |
| T8769 |
Harmaline hydrochloride
|
Harmidine hydrochloride |
Others
|
|
Harmaline hydrochloride (Harmidine hydrochloride) is a fluorescent indole alkaloid from the group of harmala alkaloids and beta-carbolines. It is the partially hydrogenated form of harmine.Harmaline produces a generalize... |
| T4S2128 |
Bilobetin
|
|
PKA
,
PPAR
|
|
Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet. |
| T5217 |
2-(2-Phenylacetamido)acetic acid
|
Phenaceturic acid,Phenyl-ac-Gly-OH,Phenylacetyl glycine |
Others
,
Endogenous Metabolite
|
|
2-(2-Phenylacetamido)acetic acid (Phenyl-ac-Gly-OH) is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids. The presence of phenylacetylglycine in urine has been confirmed for dogs, rats, and mic... |
| T2795 |
Amygdalin
|
Laetrile |
Others
|
|
Amygdalin (Laetrile) has antifibrotic, antitumor, anti-inflammatory and analgesic effects, amygdalin joint HSYA could inhibit the degeneration of the endplate chondrocytes derived from intervertebral discs of rats induce... |
| T2S2215 |
Crebanine
|
|
Apoptosis
,
Others
,
Akt
|
|
1. Crebanine iv 5mg/kg can eonvert BaCl_2-induced arrhythmia into sinus rhythm in rats, and can significantly increase the tolerant dose of aconitine to produce ventrieular fibrillation(VF) and cardiac arrest (CA) in rat... |
| T2768 |
Saikosaponin A
|
|
NF-κB
,
Antibacterial
,
Liver X Receptor
|
|
Saikosaponin A has a variety of pharmacological benefits, including antiepileptic, anti-osteoporosis, antioxidant, anti-in ammatory, immunomodulatory, and anti-bacterial activities. It can effectively attenuate neuropath... |
| T4010 |
Juglone
|
5-Hydroxy-1,4-naphthoquinone,Regianin |
DNA/RNA Synthesis
,
Antibacterial
|
|
Juglone (Regianin) is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. Juglone also irreversibly inhibits peptidyl-prolyl cis/trans isomerases of the parvulin fam... |
| T5S1889 |
Yunaconitine
|
Guayewuanine B |
Others
|
|
1. Yunaconitine (Guayewuanine B) has anti-inflammatory and analgesic actions. 2. Yunaconitine was shown to have anti-thermic effect in pyrexial rats when administered orally at a dose of 5 μg/kg. 3. Yunaconitine shows po... |
| T3676 |
Sesamol
|
1,3-Benzodioxol-5-ol,3,4-Methylenedioxyphenol |
Apoptosis
,
AMPK
|
|
Sesamol (1,3-Benzodioxol-5-ol) could decrease lung inflammation and lipopolysaccharide (LPS)-induced lung injury in rats. Sesamol ameliorates inflammatory and oxidative damage by upregulating AMPK activation and Nrf2 sig... |
| T3849 |
Kinsenoside
|
(+)-Kinsenoside |
Apoptosis
,
Nrf2
|
|
Kinsenoside ((+)-Kinsenoside) shows significant antihepatotoxic, and anti-inflammatory activities. Kinsenoside could be useful for repairing beta cells in pancreatic islet injury as well as improving its function, it cou... |
| T3388 |
Calycosin-7-O-β-D-glucoside
|
calycosin-7-O-beta-D-glucopyranoside,Calycosin-7-O-beta-D-glucoside |
MMP
,
Reactive Oxygen Species
|
|
Calycosin-7-O-β-D-glucoside (calycosin-7-O-beta-D-glucopyranoside) possesses a protective effect on rat hepatocytes, an inhibitory effect on COX-2 activity. Calycosin 7-O-β-D-glucoside has antimicrobial activity. Calycos... |
| T5294 |
(S)-Leucic acid
|
L-LEUCIC ACID,Hydroxyisocaproic acid,(S)-(−)-2-Hydroxyisocaproic acid |
Others
,
Endogenous Metabolite
|
|
(S)-Leucic acid (Hydroxyisocaproic acid) is an end product of leucine metabolism in human tissues such as muscle and connective tissue. It belongs to 2-hydroxycarboxylic acid group of amino acid metabolites. (S)-Leucic a... |
| T6S0653 |
Linarin
|
Buddleoflavonoloside,Buddleoside,Acacetin-7-O-rutinoside,Acaciin,Linarine |
TNF
,
AChE
|
|
1. Linarin (Acacetin-7-O-rutinoside) (acacetin-7-O-β-d-rutinoside) shows selective dose dependent inhibitory effect on acetylcholinesterase. 2. Linarin alleviates GalN/LPS-induced liver injury by suppressing TNF-α-mediat... |
| T40615 |
N,N'-Dimethylthiourea
|
DMTU |
Antioxidant
|
|
N,N'-Dimethylthiourea (DMTU) (DMTU), isolated from Allii Sativi Bulbus, is an orally active scavenger of hydroxyl radical ( OH) and blocks OH production by activated neutrophils in vitro. N,N'-Dimethylthiourea protects a... |
| T3976 |
Cytosporone B
|
Csn-B,Dothiorelone G |
Others
|
|
Cytosporone B (Dothiorelone G) is a naturally occurring agonist for the nuclear receptor Nur77 (IC50 = 0.278 nM). Activation of Nur77 with cytosporone B induces the expression of Nur77-dependent genes, including the gene... |
| TCS0102 |
Pulegone
|
(+)-Pulegone |
Calcium Channel
,
Endogenous Metabolite
,
TRP/TRPV Channel
|
|
1. Pulegone ((+)-Pulegone) has cytotoxicity followed by regenerative cell proliferation is the MOA for Pulegone-induced urothelial tumors in female rats. 2. Pulegone induces a verapamil-sensitive psychostimulant effect t... |
| T4S1962 |
Beta-Asarone
|
Cis-Isoasarone,Cis-Asarone,Cis-Isoelemicin |
NF-κB
,
JNK
|
|
1. beta-Asarone (Cis-Isoelemicin) may be a potential preventive drug for Alzheimer's disease. 2. Beta-Asarone prevents autophagy and synaptic loss by reducing ROCK expression in SAMP8 mice. 3. The co-administration of be... |
| T3S1553 |
Trans-Cinnamaldehyde
|
Cinnamaldehyde,Cinnamic aldehyde,Cinnamal,Phenylacrolein |
COX
,
Endogenous Metabolite
|
|
1. trans-Cinnamaldehyde (Phenylacrolein) exhibits excellent anti-inflammatory activities and antidepressant-like effects in stressed mid-aged rats as a COX-2 inhibitor. 2. Cinnamic aldehyde induces apoptosis of CML cells... |
| TJS1779 |
Protosappanin A
|
PTA |
NADPH-oxidase
,
IL Receptor
,
IκB/IKK
,
TNF
,
NF-κB
,
TLR
,
ROS
,
COX
,
HIV Protease
,
JAK
,
NO Synthase
,
STAT
|
|
Protosappanin A (PTA) has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB inflammation signal pathway; it exerts anti-neuroinflammatory ... |
| T4S21320 |
ISOGINKGETIN
|
4',4'''-Dimethylamentoflavone |
MMP
,
Others
|
|
1. ISOGINKGETIN (4',4'''-Dimethylamentoflavone), a compound derived from the leaves of Ginkgo biloba, to up-regulate adiponectin secretion with potency comparable to that of rosiglitazone, a known modulator of adiponecti... |
| T4838 |
(S)-Malic acid
|
L-(-)-Malic acid,(S)-(-)-HYDROXYSUCCINIC ACID,(S)-2-Hydroxysuccinic acid |
Others
,
Endogenous Metabolite
|
|
(S)-Malic acid ((S)-2-Hydroxysuccinic acid) is a tart-tasting organic dicarboxylic acid that plays a role in many sour or tart foods. Apples contain malic acid, which contributes to the sourness of a green apple. Malic a... |
| T3779 |
Crocin II
|
Crocin 2,Crocetin gentiobiosylglucosyl ester,Tricrocin,Crocin B |
Caspase
,
COX
,
NO Synthase
|
|
Crocin II (Crocetin gentiobiosylglucosyl ester) has anti-inflammatory and anti-apoptotic effects against gastric ischemia-reperfusion injury in rats, the effect of crocin is mainly mediated by reducing the protein expres... |
| T6S1699 |
Shogaol
|
[6]-Shogaol,6-Shogaol |
Lipoxygenase
,
Autophagy
|
|
1. 6-Shogaol (6-Shogaol) has antipyretic and analgesic effects in addition to inhibitory effect on lipoxygenase activity. 2. 6-shogaol has anti-inflammatory property, reduces the inflammatory response and protected the f... |
| T3123 |
Allicin
|
|
ERK
,
IL Receptor
,
Others
,
IκB/IKK
,
p38 MAPK
,
TNF
,
ROS
,
Caspase
,
Antifection
|
|
Allicin exerts antioxidant, bactericidal, anti-cancer, anti-inflammatory activities, it exerts an inhibitory immunomodulatory effect on intestinal epithelial cells. Allicin could significantly inhibit vascular smooth mus... |
| TN1853 |
Lariciresinol
|
|
VEGFR
,
Antifection
|
|
Lariciresinol is an enterolignan precursor, it possesses fungicidal activities by disrupting the fungal plasma membrane and therapeutic potential as a novel antifungal agent for the treatment of fungal infectious disease... |
| T3826 |
Polygalasaponin F
|
|
NF-κB
,
TLR
,
Akt
,
PI3K
|
|
Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and reduce the expression of inducible nitric oxide synthases. Po... |
