4290
140
56
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T4312 | GPR120 Agonist 2 | GPR120 receptor agonist | GPR |
GPR120 Agonist 2 is a potent and selective GPR120 receptor agonist. | |||
T38287 | C3a Receptor Agonist | C3a receptor agonist 1,Complement 3a Receptor Agonist | Complement System |
C3a Receptor Agonist (C3a receptor agonist 1) binds the G protein-coupled C3a receptors (C3aRs) in the immune system complement pathway. Activation of C3aR prevents neutrophils from being mobilized in a model of intestin... | |||
T4258 | TLR7 agonist 2 | TLR7-agonist-1,TLR7-IN-1 | TLR |
TLR7 agonist 2 (TLR7-IN-1) is a specific and effective Toll-like Receptor 7 (TLR7) agonist (LEC=0.4 μM). | |||
T4031 | S1p receptor agonist 1 | S1p-receptor-agonist-1 | S1P Receptor , LPL Receptor |
S1p receptor agonist 1 (S1p-receptor-agonist-1) is an S1P receptor agonist. | |||
T5561 | TLR7/8 agonist 1 dihydrochloride | TLR7/8 agonist-5d | TLR |
TLR7/8 agonist 1 dihydrochloride (TLR7/8 agonist-5d) is a TLR7/8 agonist which shows prominent immunostimulatory activities. | |||
T11035 | DiABZI STING agonist-1 (Tautomerism) | diABZI STING agonist (Compound 3) | STING |
diABZI STING agonist-1 (Tautomerism) (diABZI STING agonist (Compound 3)) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively. | |||
T22009 | CB2 receptor agonist 2 | ZINC72105556,4-Quinolone-3-Carboxamide Furan CB2 Agonist | Cannabinoid Receptor |
CB2 receptor agonist 2 (ZINC72105556) is a potent and selective agonist for the CB2 (cannabinoid type 2) receptor, Ki = 8.5 nM. CB2 receptor agonist 2 has high affinity and selectivity for CB2. | |||
T7623 | PAR-4 Agonist Peptide, amide | AY-NH2,PAR-4 Agonist Peptide, amide(2TFA),PAR-4-AP | Protease-activated Receptor |
PAR-4 Agonist Peptide, amide (AY-NH2) is an agonist of proteinase-activated receptor-4 (PAR-4). | |||
T9579L | GLP-1 receptor agonist 9 citrate | GLP-1 receptor agonist 9 citrate (2401892-71-3 Free base) | Glucagon Receptor |
GLP-1 receptor agonist 9 citrate is an agonist of GLP-1. | |||
T12104 | MRGPRX1 agonist 1 | Others | |
MRGPRX1 agonist 1 is a highly potent MRGPRX1 (Mas-related G-protein-coupled receptor X1)agonist(EC50 of 50 nM). | |||
T7833 | TLX agonist 1 | Others | |
TLX agonist 1 is an orphan nuclear receptor tailless (TLX, NR2E1) modulator | |||
T1779 | SAG | Smoothened Agonist (SAG) HCl,Smoothened Agonist | Hedgehog/Smoothened , Smo |
SAG (Smoothened Agonist) is a Smo receptor agonist (EC50=3 nM) that is cell-permeable and selective. SAG regulates Smo activity by binding directly to the Smo helix and can activate the Hedgehog signaling pathway. | |||
T13015 | STING agonist-4 | STING | |
STING agonist-4 is an agonist of stimulator of Interferon Genes (STING) receptor(IC50 of 20 nM). | |||
T15413 | GPR120 Agonist 3 | GPR120-IN-1 | GPR |
GPR120 Agonist 3 (GPR120-IN-1) is a selective agonist of Gpr120 ( logEC50: -7.62). | |||
T11095L | DREADD agonist 21 | 5-HT Receptor , Adrenergic Receptor , AChR , Histamine Receptor | |
DREADD agonist 21 is a potent agonist of human muscarinic acetylcholine M3 receptors (EC50=1.7 nM). | |||
T40685L | Orphan GPCR SP9155 agonist P550 (mouse, rat) acetate | Orphan GPCR SP9155 agonist P550 (mouse, rat) acetate (600171-70-8 Free base) | Others |
Orphan GPCR SP9155 agonist P550 (mouse, rat) acetate (Orphan GPCR SP9155 agonist P550 ) is a member of the RFamide peptide family with orexigenic effects. | |||
T12753 | RORγt Inverse agonist 6 | ROR | |
T17005 | FPR Agonist 43 | Others | |
FPR Agonist 43 is a dual agonist of formyl peptide receptor 1 and formyl peptide receptor 2 (FPR2)/ALX. | |||
T9623 | RORγt inverse agonist 13 | ROR | |
RORγt inverse agonist 13 (Compound 3i) is a potent, orally active and selective RORγt inverse agonist (IC50=63.8 nM), with improved drug-like properties[1]. | |||
T13167 | TLR7/8 agonist 3 | TLR | |
TLR7/8 agonist 3 is a potent agonist of TLR7 and TLR8. | |||
T12165 | NAChR agonist 1 | DUN71755 | AChR |
nAChR agonist 1 (DUN71755) is a brain-permeable and orally efficacious positive allosteric α7 nicotinic acetylcholine receptor (α7 nAChR)modulator. | |||
T8328 | STING agonist-1 | G10 | Virus Protease , STING |
STING agonist-1 (G10) is a human-specific STING agonist,elicits antiviral activity against emerging Alphaviruses. | |||
T10212 | A2AR-agonist-1 | N-(2-(1H-Indol-3-yl)ethyl)adenosine | Others , Adenosine Receptor |
A2AR-agonist-1 (N-(2-(1H-Indol-3-yl)ethyl)adenosine) is a potent A2AR and ENT1 agonist (Ki: 4.39 and 3.47 for A2AR and ENT1. It targets the Adenosine A2A Receptor and Adenosine Transporter for Neuroprotection. | |||
T10694 | CB1 inverse agonist 1 | MRL-650 | Cannabinoid Receptor |
CB1 inverse agonist 1 (MRL-650) is an orally active and selective CB1 agonist. The IC50s for CB1 and CB2 are 7.5 nM and 4100 nM, respectively. CB1 inverse agonist 1 shows anorexigenic effects. | |||
T10659 | Ca2+ channel agonist 1 | Calcium Channel , CDK | |
Ca2+ channel agonist 1 is an agonist of N-type Ca2+ channel and an inhibitor of Cdk2 (EC50s: 14.23 μM and 3.34 μM) and is used as a potential treatment for motor nerve terminal dysfunction. | |||
T36579 | GLP-1R Agonist DMB | Glucagon Receptor | |
GLP-1R Agonist DMB is an agonist of glucagon-like peptide 1 receptor (GLP-1R; KB = 26.3 nM for the recombinant human receptor). | |||
T77549 | Nurr1 agonist 2 | Others | |
Nurr1 agonist 2 is a Nurr1 agonist with an EC50 value of 0.07 μM. Nurr1 agonist 2 increases the mRNA expression of the Nurr1-regulated genes tyrosine hydroxylase (TH) and vesicular amino acid transporter 2 (VMAT2). Nurr1... | |||
T67831 | HIF-2α agonist 2 | HIF/HIF Prolyl-Hydroxylase , HIF | |
HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for HIF-2α. HIF-2α agonist 2 can promote the stability of the ARNT A/B ring in the 3z structure of HIF-2a-ARNT complex without cytotoxicity to 786-o-Reh... | |||
T23434 | GPR35 agonist 2 | TC-G 1001 | GPR , Arrestin |
GPR35 agonist 2 (TC-G 1001) is a potent GPR35 agonist.The EC50 values of GPR35 agonist 2 in the β-arrestin and Ca2+ release assays were 26 and 3.2 nM, respectively. | |||
T3177 | Orexin 2 Receptor Agonist | OX2R | OX Receptor |
Orexin 2 Receptor Agonist (OX2R) is an effective (EC50: 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio: 70) agonist. | |||
T13214L | TRPV4 agonist-1 free base | OUN67600 | TRP/TRPV Channel |
TRPV4 agonist-1 free base (OUN67600) is an agonist of transient receptor potential vanilloid 4 (TRPV4;EC50 of 60 nM, in the hTRPV4 Ca2+ assay). | |||
T9889 | M4 mAChR agonist-1 | 4-Piperidinecarboxamide, 1-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)- | AChR |
M4 mAChR agonist-1 (4-Piperidinecarboxamide, 1-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)-) is an effective agonist of M4 mAChR (EC50 >10 μM). | |||
T3144 | BML-284 | Wnt agonist 1 | Wnt/beta-catenin |
BML-284 (Wnt agonist 1) is a potent, selective and , cell-permeable Wnt signaling activator. | |||
T9988 | Wnt/β-catenin agonist 3 | Wnt/beta-catenin | |
Wnt/β-catenin agonist 3 is a Wnt/beta-catenin agonist. | |||
T41094 | Wnt/β-catenin agonist 2 | GSK-3 , Wnt/beta-catenin | |
Wnt/β-catenin agonist 2 activates Wnt/β-catenin signaling and is an effective Wnt agonist. Wnt/β-catenin agonist 2 can be used in the study of diseases related to signal transduction and is closely related to cancer inva... | |||
T37908 | Glucocorticoid receptor agonist-1 | Glucocorticoid Receptor | |
Glucocorticoid receptor agonist-1 is a potent glucocorticoid receptor agonist with an IC50 of 2.8 nM[1]. | |||
T60074 | GPCR agonist-2 | 4-(Cyclopropylamino)-3-nitrobenzoic acid | GPR |
GPCR agonist-2 (4-(Cyclopropylamino)-3-nitrobenzoic acid) is an agonist of the orphan human GPCR GPR109B. | |||
T1824 | TGR5 Receptor Agonist | GPCR19 | |
TGR5 is a potent TGR5(GPCR19) agonist. | |||
T7799 | BMP signaling agonist sb4 | SB 4 | TGF-beta/Smad |
BMP signaling agonist sb4 (SB 4) is an agonist of benzoxazole bone morphogenetic protein (BMP) signaling (EC50 :74 nM) | |||
T10170 | 5-HT7 agonist 1 | 4-[4-[(2-chlorophenyl)methyl]-1-piperazinyl]-1H-indole,4-[4-[(2-chlorophenyl)methyl]piperazin-1-yl]-1H-indole,4-[4-(2-chlorobenzyl)piperazino]-1H-indole | 5-HT Receptor |
5-HT7 agonist 1 (4-[4-[(2-chlorophenyl)methyl]piperazin-1-yl]-1H-indole) is a selective agonist of 5-HT7 (IC50 = 222.93 nM). 5-HT7 agonist 1 can be used in studies about CNS disorders. | |||
T9579 | GLP-1 receptor agonist 9 | Glucagon Receptor | |
1H-Benzimidazole-6-carboxylic acid is a GLP-1 receptor agonist. | |||
T5516 | DiABZI STING agonist-1 trihydrochloride | STING | |
diABZI STING agonist-1 (trihydrochloride) is stimulator of interferon genes (STING) receptor agonist. | |||
T9157 | GP130 receptor agonist-1 | N-(4-Fluorophenyl)-4-phenyl-2-thiazolami | Interleukin |
GP130 receptor agonist-1 (N-(4-Fluorophenyl)-4-phenyl-2-thiazolami) is a potent, brain-penetrant and orally active GP130 receptor agonist. | |||
TP1065 | PAR-4 Agonist Peptide, amide TFA | PAR-4-AP (TFA),AY-NH2 (TFA) | Protease-activated Receptor |
PAR-4 Agonist Peptide, amide TFA (PAR-4-AP (TFA)), is a selective activator of the proteinase-activated receptor-4 (PAR-4), demonstrating specificity by not influencing PAR-1 or PAR-2, and its activity can be inhibited b... | |||
T38836L | Protease-Activated Receptor-1, PAR-1 Agonist acetate | Protease-activated Receptor | |
Protease-Activated Receptor-1, PAR-1 Agonist acetate is a selective proteinase-activated receptor1 (PAR-1) agonist peptide. Protease-Activated Receptor-1, PAR-1 Agonist acetate corresponds to PAR1 tethered ligand and whi... | |||
T33613 | NCGC00135472 | NCGC 00135472,DRV1 (GPR32) agonist C2A,C2A,NCGC-00135472 | Others |
NCGC00135472 (DRV1 (GPR32) agonist C2A) is a human Resolvin DI receptor DRV1 agonist with pro-catabolic properties that activates the human soluble protein D1 receptor DRV1/GPR32 receptor in beta-blocker and cAMP assays ... | |||
T38161 | STING Agonist C11 | STING Agonist C11 | |
STING agonist C11 is an agonist of the stimulator of interferon genes (STING) pathway.1 It induces secretion of type I IFN from THF and MM6 cells when used at a concentration of 50 μM. STING agonist C11 induces phosphory... | |||
T40517 | GPR30 agonist-1 | GPR30 agonist-1 | |
GPR30 agonist-1 is a compound that acts as an agonist for G protein-coupled receptor 30 (GPR30), inducing vasorelaxation. | |||
T15812 | LY2979165 | mGlu2 agonist | GluR |
LY2979165 (mGlu2 agonist) is an orthosteric agonist of mGluR2 and can be used in studies about serving as an anti-depressant. | |||
T60075 | Dopamine D2 receptor agonist-2 | Dopamine D2 Receptor | Dopamine Receptor |
Dopamine D2 receptor agonist-2 (Dopamine D2 Receptor) is a ligand targeting the dopamine D2 receptor. |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
TN7060 | Methyl oleanonate | PPAR | |
3-Oxoolean-12-en-28-oic acid methyl ester is a triterpenoid PPARγ agonist isolated from Pistacia with anticancer properties. | |||
T1286 | Vincamine | Angiopac,Oxybral,Devincan,Novicet,Equipur,Perval | GPR , Others |
Vincamine (Perval) is a major alkaloid of Vinca minor L., Apocynaceae. It has been used therapeutically as a vasodilator and antihypertensive agent, particularly in cerebrovascular disorders. | |||
TN1055 | Licochalcone E | TNF , Liver X Receptor , PPAR | |
Licochalcone E is a potential LXRβ agonist. | |||
T15643 | Kainic acid | Others | |
In the CNS, Kainic acid is an effective agonist at excitatory amino acid receptor subtypes. | |||
T23306 | Salvinorin A | Opioid Receptor | |
Salvinorin A is a non-nitrogenous κ-opioid selective agonist. | |||
T9114 | β-Caryophyllene | (-)-(E)-Caryophyllene,(−)-β-caryophyllene,(−)-trans-Caryophyllene | Cannabinoid Receptor , Endogenous Metabolite |
β-Caryophyllene ((-)-(E)-Caryophyllene) acts as an CB2 receptor agonist. | |||
T1683 | Actriol | Epiestriol | Glucocorticoid Receptor |
Actriol (Epiestriol) is always used as Glucocorticoid Receptor agonist. | |||
TQ0203 | Tafluprost | MK2452,AFP-168 | Prostaglandin Receptor |
Tafluprost, a prostaglandin analog, is the selective agonist of fluoroprostaglandin (FP) receptor PGF2α. | |||
T8035 | 3'-Methoxyflavonol | NMU2R | |
3'-Methoxyflavonol is a potent, selective agonist of neuromedin U 2 receptor (NMU2R). | |||
T12296 | Oleoylethanolamide | N-Oleoylethanolamide,Oleamide MEA,Oleic acid monoethanolamide | Endogenous Metabolite , PPAR |
Oleoylethanolamide (N-Oleoylethanolamide) is a high affinity endogenous agonist of PPAR-α. | |||
T5805 | Guvacoline hydrochloride | Norarecoline hydrochloride | AChR |
Guvacoline hydrochloride (Norarecoline hydrochloride) is a muscarinic agonist. | |||
T8299 | Dimethyl lithospermate B | dmLSB | Sodium Channel |
Dimethyl lithospermate B (dmLSB) is a selective Na+ channel agonist. | |||
T12095 | Monomethyl fumarate | GPR , Drug Metabolite | |
Monomethyl fumarate is a potent agonist of GPR109A . | |||
T2870 | Matrine | Vegard,Matridin-15-one,Matrinium,α-Matrine,(+)-Matrine | Mitophagy , Ferroptosis , Opioid Receptor , Autophagy |
Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist. | |||
T7974 | Lynestrenol | Progesterone Receptor | |
Lynestrenol is a synthetic progestational hormone, is the progesterone receptor agonist | |||
T3362 | Eupatilin | NSC 122413 | PPAR , Autophagy |
Eupatilin (NSC-122413), a flavone derived from Artemisia princepsPampanini, is a PPARα agonist, with pharmacological activity. | |||
T3668 | Galangin | Norizalpinin,3,5,7-Trihydroxyflavone | ERK , P450 , NF-κB , Autophagy |
Galangin (Norizalpinin) is an agonist/antagonist of the arylhydrocarbon receptor, and also shows inhibition of CYP1A1 activity. | |||
TN1927 | Methyl Kakuol | 1-(6-methoxy-1,3-benzodioxol-5-yl)propan-1-one | TRP/TRPV Channel |
Methyl Kakuol is an agonist of TRPA1 with an EC50 of 0.27 µM and can be used in studies about acting as an active ingredient in MBST constituent Asiasari Radix. | |||
T0453 | Phenylephrine hydrochloride | NCI-c55641,Phenylephrine HCl,(R)-(-)-Phenylephrine hydrochloride | Endogenous Metabolite , Adrenergic Receptor |
Phenylephrine hydrochloride (NCI-c55641) is a selective agonist of the α1-adrenergic receptor. | |||
T7117 | Sapropterin dihydrochloride | Sapropterin Hydrochloride,6R-Tetrahydro-L-biopterin dihydrochloride,6R-BH4 dihydrochloride | Hydroxylase |
Sapropterin dihydrochloride (6R-BH4 dihydrochloride) is phenylalanine hydroxylase agonist that is approved for the treatment of BH4 responsive PKU. | |||
T1704 | Diosmetin | Luteolin 4-methyl ether | P450 , Trk receptor |
Diosmetin (Luteolin 4-methyl ether) has been found to act as a weak TrkB receptor agonist. | |||
T7224 | Anabasine | (S)-Anabasine,(-)-Anabasine | AChR |
Anabasine ((S)-Anabasine) is an alkaloid extracted from tobacco. Anabasine is a full agonist of nicotinic acetylcholine receptors (nAChRs) with insecticidal activity. Anabasine depolarizes TE671 cells endogenously expres... | |||
T37709 | 2,2,2-Trichloroethanol | Potassium Channel , Endogenous Metabolite | |
2,2,2-Trichloroethanol, the active form of the sedative hypnotic drug chloral hydrate, is an agonist for the nonclassical K2P channels TREK-1 (KCNK2) and TRAAK (KCNK4)[1]. 2,2,2-trichloroethanol activates a nonclassical ... | |||
T3325 | Liquiritigenin | 4',7-Dihydroxyflavanone | Estrogen Receptor/ERR , Estrogen/progestogen Receptor |
Liquiritigenin (4',7-Dihydroxyflavanone), a flavonoid aglycone from licorice, is a highly selective estrogen receptor β (ERβ) agonist. | |||
T6662 | Scopine | 6,7-Epoxytropine | Adrenergic Receptor |
Scopine (6,7-Epoxytropine), the metabolite of anisodine, is an α1-adrenergic receptor agonist used in the therapy of acute circulatory shock. | |||
T2198 | Arecoline hydrobromide | Arecoline HBr,Arecoline bromide | AChR |
Arecoline hydrobromide (Arecoline HBr) is a muscarinic acetylcholine receptor agonist. | |||
T6519 | Gramine | NSC 16892,Donaxine | Adiponectin receptor , Reverse Transcriptase , Adrenergic Receptor |
Gramine (Donaxine), a natural indole alkaloid, present in several plant species, acts as an active adiponectin receptor (AdipoR) agonist, with IC50s of 3.2 and 4.2 μM for AdipoR2 and AdipoR1, respectively. Gramine is als... | |||
T17310 | Phenylephrine | L-Phenylephrine,(R)-(-)-Phenylephrine | Adrenergic Receptor |
Phenylephrine ((R)-(-)-Phenylephrine) is a selective α1-adrenoceptor agonist ( pKi: 5.86, 4.87 and 4.70 for α1D, α1B, and α1A receptors respectively). | |||
T0804 | Pilocarpine Hydrochloride | NSC 5746 HCl,Pilocarpine HCl,(+)-Pilocarpine hydrochloride | AChR |
Pilocarpine Hydrochloride (NSC 5746 HCl) , a nonselective muscarinic acetylcholine receptor agonist, is utilized to produce an experimental model of epilepsy. | |||
T6688 | Synephrine hydrochloride | Oxedrine hydrochloride,Synephrine HCl | Endogenous Metabolite , Adrenergic Receptor |
Synephrine hydrochloride (Oxedrine hydrochloride) is an agonist that acts on sympathomimetic α-adrenergic receptor (AR). | |||
T8895 | Altenusin | FXR | |
Altenusin is a natural nonsteroidal fungal metabolite, as a novel selective agonist of FXR with an EC50 value of 3.2 ± 0.2 μM. | |||
T13456 | (S)-Willardiine | (-)-Willardiine,L-willardiine,Willardiine | iGluR |
(S)-Willardiine (L-willardiine) is present in the seeds of Acacia and Mimosa. (S)-Willardiine is an AMPA/kainate receptor agonist (EC50 = 44.8 μM). | |||
TN1296 | 5-Feruloylquinic acid | 5-O-Feruloylquinic acid,5-FQA | Tyrosinase , Sirtuin |
5-Feruloylquinic acid (5-FQA) is a potent Sirt1 agonist, it is a potential lead compound that can be further tested in drug development process for diseases associated with aging. | |||
T0268 | Lobeline hydrochloride | α-Lobeline hydrochloride,L-Lobeline hydrochloride | AChR |
Lobeline hydrochloride (α-Lobeline hydrochloride) is a nicotinic receptor agonist, acting as an effective antagonist at both α4β2 and α3β2 neuronal nicotinic receptor subtypes. | |||
T1352 | ATP disodium salt | Adenosine 5'-triphosphate disodium salt,ATP,ATP disodium,Adetide,Adenosine-Triphosphate,Disodium adenosine triphosphate | P2X Receptor , Endogenous Metabolite |
ATP disodium salt (Adenosine-Triphosphate) is a P2 purinoceptor agonist. | |||
TN1248 | 3-Epioleanolic acid | AChR | |
3-Epioleanolic acid and oleanonic acid possess varying degrees of agonist activity on uterine smooth muscle with minor changes in the molecular structure affecting its intrinsic activity on uterine muscle. | |||
TQ0274 | 27-Hydroxycholesterol | 25(R)-27-hydroxy Cholesterol | Estrogen/progestogen Receptor , Liver X Receptor |
T1287 | Synephrine | Oxedrine | Endogenous Metabolite , Adrenergic Receptor |
Synephrine (Oxedrine) is sympathetic alpha-adrenergic agonist used as a vasoconstrictor in circulatory failure, asthma, nasal congestion, and glaucoma. | |||
T1231 | Pilocarpine nitrate | Pilagan,Pilofrin | AChR |
Pilocarpine nitrate (Pilagan) is a slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma. | |||
T13092 | Tauro-Obeticholic acid | FXR | |
Tauro-Obeticholic acid is an active Obeticholic acid metabolite. Obeticholic acid is an orally bioavailable agonist of farnesoid-X receptor (FXR). | |||
TQ0279 | Ibotenic acid | (+/-)-Ibotenic acid,DL-Ibotenic acid,Ibotenate,(RS)-Ibotenic acid | NMDAR |
Ibotenic acid (RS-42358-197) has agonist activity at both the NMDA and trans-ACPD or metabotropic quisqualate receptors. | |||
T2209 | Serotonin hydrochloride | 5-HT hydrochloride,5-HT HCl,Serotonin HCl,5-Hydroxytryptamine hydrochloride | 5-HT Receptor , Endogenous Metabolite , Transferase |
Serotonin hydrochloride (Serotonin HCl) is an endogenous 5-HT receptor agonist, a monoamine neurotransmitter in the CNS, and a catechol O-methyltransferase (COMT) inhibitor(Ki=44 μM). | |||
T3000 | Magnolol | NSC 293099,5,5'-Diallyl-2,2'-biphenyldiol | NF-κB , Retinoid Receptor , Antibacterial , PPAR , p53 , Autophagy |
Magnolol (5,5'-Diallyl-2,2'-biphenyldiol) is a dual agonist of RXRα( EC50=10.4 μM) and PPARγ(EC50=17.7 μM). It blocks TNF-α-induced NF-KB activation. | |||
T9719 | 3-Hydroxyoctanoic Acid | GPR | |
3-Hydroxyoctanoic Acid is one of the hydroxy-carboxylic acids (HCAs) that serve as intermediates of energy metabolism. It is an agonist of the orphan receptor GPR109B. | |||
T0505 | Methyldopa | L-(-)-α-Methyldopa,MK-351 | Dopamine Receptor , Adrenergic Receptor |
Methyldopa (MK-351), an alpha-adrenergic agonist (selective for α2-adrenergic receptors) psychoactive medicine, is served as an antihypertensive or sympatholytic. | |||
T5081 | Adenine monohydrochloride hemihydrate | Adenine hydrochloride hydrate,6-Aminopurine hydrochloride hydrate | Endogenous Metabolite , Adenosine Receptor |
Adenine monohydrochloride hemihydrate is a high affinity adenine receptor agonist (Ki = 18 nM at rat adenine receptor). It inhibits forskolin-stimulated cAMP formation in CHO cells transfected with the adenine receptor a... | |||
T4885 | (-)-Aspartic acid | (R)-Aspartic acid,Asp,D-(-)-Aspartic acid,Aminosuccinic acid,asparagic acid,L-Homoproline,D-Aspartic acid | Endogenous Metabolite , NMDAR , iGluR |
(-)-Aspartic acid (L-Homoproline) is an endogenous amino acid existing in invertebrates and vertebrates. It can regulate testosterone synthesis and is an agonist of NMDA receptor. | |||
T60237 | L-Cysteine S-sulfate | S-Sulfo-L-cysteine | NMDAR |
L-Cysteine S-sulfate (S-Sulfo-L-cysteine) is an effective N-methyl-d-aspartate (NMDA) glutamatergic receptors agonist. L-Cysteine S-sulfate is the substrate for cystine lyase [1]. | |||
T6608 | NMDA | N-Methyl-D-aspartic acid | Endogenous Metabolite , NMDAR , iGluR |
N-Methyl-D-aspartic acid is an amino acid that, as the D-isomer, is the defining agonist for the NMDA (N-Methyl-D-aspartic acid) receptor subtype of glutamate receptors. | |||
T2177 | Kaempferol | Kempferol,Robigenin | Apoptosis , Estrogen Receptor/ERR , Mitophagy , Estrogen/progestogen Receptor , HIV Protease , Endogenous Metabolite , Parasite , Autophagy |
Kaempferol (Robigenin) is a natural flavonoid and an inverse agonist of ERRα and ERRγ. Kaempferol has a wide range of antitumor, anti-inflammatory, antioxidant, antibacterial and antiviral activities. | |||
------------------------ More ------------------------ |
カタログ番号 | 製品名 | Species | Expression System |
---|---|---|---|
TMPY-02027 | BID Protein, Human, Recombinant | Human | E. coli |
The BH3 interacting domain death agonist (BID) is a pro-apoptotic member of the Bcl-2 protein family, which contains only the BH3 domain, and is required for its interaction with the Bcl-2 family proteins and for its pro... | |||
TMPY-02065 | BID Protein, Mouse, Recombinant (His & GST) | Mouse | E. coli |
The BH3 interacting domain death agonist (BID) is a pro-apoptotic member of the Bcl-2 protein family, which contains only the BH3 domain, and is required for its interaction with the Bcl-2 family proteins and for its pro... | |||
TMPY-02650 | Alkaline phosphatase Protein, Human, Recombinant (His) | Human | HEK293 |
ALPI encodes for intestinal phosphatase alkaline, a brush border metalloenzyme that hydrolyses phosphate from the lipid A moiety of lipopolysaccharides and thereby drastically reduces Toll-like receptor 4 agonist activit... | |||
TMPY-03848 | Protein S/PROS1 Protein, Human, Recombinant (His) | Human | HEK293 |
PROS1, also known as protein S, is a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. PROS1 has two isoforms: a free,... | |||
TMPY-01214 | IL-6R Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (SIL-6R) acts as an agonist of IL-6 activity. In... | |||
TMPY-05278 | IL-6R Protein, Human, Recombinant (hFc) | Human | HEK293 |
Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (SIL-6R) acts as an agonist of IL-6 activity. In... | |||
TMPY-00864 | IL-6R Protein, Human, Recombinant (His) | Human | HEK293 |
Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (SIL-6R) acts as an agonist of IL-6 activity. In... | |||
TMPY-05435 | ANGPT1/Angiopoietin-1 Protein, Human, Recombinant (hFc) | Human | HEK293 |
The angiopoietin (ANGPT)-TIE2/TEK signaling pathway is essential for blood and lymphatic vascular homeostasis. ANGPT1 is a potent TIE2 activator, whereas ANGPT2 functions as a context-dependent agonist/antagonist. In dis... | |||
TMPY-01774 | TREM-1 Protein, Human, Recombinant (His) | Human | HEK293 |
TREM1 (triggering receptor expressed on myeloid cells) is a type I transmembrane protein with a single Ig-like domain, and is selectively expressed on blood neutrophils and a subset of monocytes. As a member of the growi... | |||
TMPY-03645 | BAFF/TNFSF13B Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 |
B lymphocyte stimulator (BLyS), also known as TNFSF13B, CD257 and BAFF, is a single-pass type II membrane protein, which belongs to the tumor necrosis factor family. BAFF is abundantly expressed in peripheral blood Leuko... | |||
TMPY-01920 | BAFF/TNFSF13B Protein, Human, Recombinant (HEK293) | Human | HEK293 |
B lymphocyte stimulator (BLyS), also known as TNFSF13B, CD257 and BAFF, is a single-pass type II membrane protein, which belongs to the tumor necrosis factor family. BAFF is abundantly expressed in peripheral blood Leuko... | |||
TMPY-05365 | BAFF/TNFSF13B Protein, Human, Recombinant (Avi & Fc), Biotinylated | Human | HEK293 |
B lymphocyte stimulator (BLyS), also known as TNFSF13B, CD257 and BAFF, is a single-pass type II membrane protein, which belongs to the tumor necrosis factor family. BAFF is abundantly expressed in peripheral blood Leuko... | |||
TMPJ-00303 | ANG2 Protein, Mouse, Recombinant (hFc) | Mouse | Human Cells |
Angiopoietin-2 (Ang-2; also ANGPT2) is a secreted glycoprotein that plays a complex role in angiogenesis and inflammation. Both Ang-2 and the related Angiopoietin-1 (Ang-1) are ligands for the receptor tyrosine kinase Ti... | |||
TMPJ-01435 | ANG2 Protein, Rhesus macaque, Recombinant (hFc) | Rhesus Macaque | Human Cells |
Angiopoietin-2 (Ang-2; also ANGPT2) is a secreted glycoprotein that plays a complex role in angiogenesis and inflammation. Both Ang-2 and the related Angiopoietin-1 (Ang-1) are ligands for the receptor tyrosine kinase Ti... | |||
TMPH-01719 | OPRM1 Protein, Human, Recombinant (His) | Human | in vitro E. coli expression system |
Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to th... | |||
TMPY-02668 | NAALADL1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
N-acetylated-alpha-linked acidic dipeptidase-like protein, also known as NAALADL1, NAALADase L, and Ileal dipeptidyl-peptidase, is a Single-pass type II membrane protein and a member of the peptidase M28 family and M28B ... | |||
TMPH-02253 | TPM2 Protein, Human, Recombinant (His) | Human | E. coli |
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contra... | |||
TMPY-01215 | NAALADL1 Protein, Human, Recombinant (His) | Human | HEK293 |
N-acetylated-alpha-linked acidic dipeptidase-like protein, also known as NAALADL1, NAALADase L, and Ileal dipeptidyl-peptidase, is a Single-pass type II membrane protein and a member of the peptidase M28 family and M28B ... | |||
TMPY-04555 | GRK5 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
G protein-coupled receptor kinase 5, also known as G protein-coupled receptor kinase GRK5 and GRK5, is a member of the protein kinase superfamily, AGC Ser/Thr protein kinase family, and GPRK subfamily. GRKs specifically ... | |||
TMPY-02713 | Alkaline phosphatase Protein, Human, Recombinant (hFc) | Human | HEK293 |
ALPI encodes for intestinal phosphatase alkaline, a brush border metalloenzyme that hydrolyses phosphate from the lipid A moiety of lipopolysaccharides and thereby drastically reduces Toll-like receptor 4 agonist activit... | |||
TMPK-00636 | BID Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Bid, BH3-interacting domain death agonist, was initially cloned based in its ability to interact with both Bcl-2 and Bax. Bid contains only the BH3 domain, which is required for its interaction with the Bcl-2 family prot... | |||
TMPH-02409 | LprG Protein, Mycobacterium tuberculosis, Recombinant (His & Myc) | Mycobacterium tuberculosis | E. coli |
Probably helps membrane protein MT1454 (P55) transport triacylglycerides (TAG) across the inner cell membrane into the periplasm and probably ultimately to the outer membrane. TAG probably regulates lipid metabolism and ... | |||
TMPH-02540 | GRK2 Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli |
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to... | |||
TMPH-01315 | CASR Protein, Human, Recombinant (GST) | Human | E. coli |
G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis. Senses fluctuations in the circulating calcium concentration and ... | |||
TMPY-06708 | Protein S/PROS1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
PROS1, also known as protein S, is a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. PROS1 has two isoforms: a free,... | |||
TMPJ-00983 | ARRB1 Protein, Human, Recombinant (His) | Human | E. coli |
β-Arrestin-1 (ARRB1) is a cytoplasmic protein that belongs to the arrestin family. ARRB1 is expressed at high levels in peripheral blood leukocytes and the central nervous system. ARRB1 regulates agonist-mediated G-prote... | |||
TMPJ-00484 | SHMT1 Protein, Human, Recombinant (His) | Human | Human Cells |
Serine Hydroxymethyltransferase Cytosolic (SHMT1) is a member of the SHMT family. SHMT1 is a cytoplasmic protein and exists as a homotetramer. SHMT1 catalyzes the reversible conversion of serine and tetrahydrofolate to g... | |||
TMPH-02458 | PRNP Protein, Mesocricetus auratus, Recombinant (His & Myc) | Mesocricetus auratus | E. coli |
Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an ... | |||
TMPY-06315 | Protein S/PROS1 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
PROS1, also known as protein S, is a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. PROS1 has two isoforms: a free,... | |||
TMPH-01393 | GRIA3 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many ... | |||
TMPH-01035 | CNR1 Protein-VLP, Human, Recombinant (His) | Human | HEK293 |
G-protein coupled receptor for endogenous cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG), as well as phytocannabinoids, such as delta(9)-tetrah... | |||
TMPJ-00291 | IL-6R alpha/CD126 Protein, Human, Recombinant (Avi & His), Biotinylated | Human | Human Cells |
Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. IL6Ra is a part of the receptor for interleukin 6 cytokine. IL6Ra binds to... | |||
TMPY-04859 | IL-6R Protein, Rhesus, Recombinant (His) | Rhesus | HEK293 |
Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (SIL-6R) acts as an agonist of IL-6 activity. In... | |||
TMPY-04187 | IL-6R Protein, Rat, Recombinant (hFc) | Rat | HEK293 |
Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (SIL-6R) acts as an agonist of IL-6 activity. In... | |||
TMPY-00135 | IL-6R Protein, Canine, Recombinant (His) | Canine | HEK293 |
Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (SIL-6R) acts as an agonist of IL-6 activity. In... | |||
TMPY-02560 | IL-6R Protein, Rat, Recombinant (His) | Rat | HEK293 |
Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (SIL-6R) acts as an agonist of IL-6 activity. In... | |||
TMPY-06297 | IL-6R Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (SIL-6R) acts as an agonist of IL-6 activity. In... | |||
TMPY-05640 | IL-6R Protein, Human, Recombinant, Biotinylated | Human | HEK293 |
Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (SIL-6R) acts as an agonist of IL-6 activity. In... | |||
TMPH-01392 | GRIA2 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system. It plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many ... | |||
TMPY-01824 | Caspase-14 Protein, Human, Recombinant (His) | Human | E. coli |
Caspase 14 is a member of the caspase family. Caspases are a kind of cysteine proteinase consisting of a prodomain plus large and small catalytic subunits, that play a central role in cell apoptosis. Caspase 14 possesses... | |||
TMPJ-00789 | Flagellin Protein, Salmonella Typhimurium, Recombinant | Salmonella typhimurium | E. coli |
Flagellin is the major structural protein monomer of bacterial flagella. Flagellin through binding to its receptor and activation of antigen presenting cells stimulates the innate and adaptive immune responses. Flagellin... | |||
TMPY-00044 | CYTL1 Protein, Human, Recombinant (mFc) | Human | HEK293 |
Cytokine-like protein 1 (CYTL1) is a small widely expressed secreted protein lacking significant primary sequence homology to any other known protein. Cytokine-like 1 (CYTL1) is a novel potential cytokine that was first ... | |||
TMPY-05351 | ANGPT1/Angiopoietin-1 Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 |
The angiopoietin (ANGPT)-TIE2/TEK signaling pathway is essential for blood and lymphatic vascular homeostasis. ANGPT1 is a potent TIE2 activator, whereas ANGPT2 functions as a context-dependent agonist/antagonist. In dis... | |||
TMPY-02654 | FDPS Protein, Human, Recombinant (His) | Human | E. coli |
Z-farnesyl diphosphate synthase (FDPS) is an enzyme belonging to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. Z-farnesyl diphosphate synthase (FDPS) functions... | |||
TMPY-00451 | FDPS Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Z-farnesyl diphosphate synthase (FDPS) is an enzyme belonging to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. Z-farnesyl diphosphate synthase (FDPS) functions... | |||
TMPY-00366 | ANGPT1/Angiopoietin-1 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
The angiopoietin (ANGPT)-TIE2/TEK signaling pathway is essential for blood and lymphatic vascular homeostasis. ANGPT1 is a potent TIE2 activator, whereas ANGPT2 functions as a context-dependent agonist/antagonist. In dis... | |||
TMPY-04245 | ANGPT1/Angiopoietin-1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
The angiopoietin (ANGPT)-TIE2/TEK signaling pathway is essential for blood and lymphatic vascular homeostasis. ANGPT1 is a potent TIE2 activator, whereas ANGPT2 functions as a context-dependent agonist/antagonist. In dis... | |||
TMPY-02807 | TWSG1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
TWSG1 belongs to the twisted gastrulation protein family. TWSG1 from different species are functionally equivalent. In contrast to Drosophila where TWSG1 expression is limited to early embryos, expression of TWSG1 is fou... | |||
TMPY-00943 | TREM-1 Protein, Human, Recombinant (His & hFc) | Human | HEK293 |
TREM1 (triggering receptor expressed on myeloid cells) is a type I transmembrane protein with a single Ig-like domain, and is selectively expressed on blood neutrophils and a subset of monocytes. As a member of the growi... | |||
TMPY-06527 | TREM-1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
TREM1 (triggering receptor expressed on myeloid cells) is a type I transmembrane protein with a single Ig-like domain, and is selectively expressed on blood neutrophils and a subset of monocytes. As a member of the growi... | |||
------------------------ More ------------------------ |