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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T22260 | Aminopurvalanol A | CDK | |
Aminopurvalanol A is a competitive, selective and cell-permeable inhibitor of cyclin-dependent kinase (CDK) that potently inhibits Cyclin A/cdk2, Cyclin B/cdk1, Cyclin E/cdk2, and P35/cdk5 with IC50 of 33 nM, 33 nM, 28 n... | |||
T9963 | MPT0B390 | HDAC | |
MPT0B390 is an inhibitor of HDAC and a TIMP3 inducer inhibiting tumor growth, metastasis, and angiogenesis. | |||
T6400 | AZD3514 | Androgen Receptor | |
AZD3514 is a potent and oral androgen receptor downregulator with Ki of 2.2 μM and has ability of reducing AR protein expression.Phase 1. | |||
T29670 | ADR-925 | ICRF198,ICRF-198,ADR 925,ICRF 198,ADR925 | Endogenous Metabolite |
ADR-925 (ICRF 198), an active chelated iron metabolite of dexrazoxane, has the ability to protect neonatal rat cardiomyocytes from adriamycin-induced injury. | |||
T7491 | 6-O-Methyl Guanosine | Nucleoside Antimetabolite/Analog | |
6-O-Methyl Guanosine inhibit colony-forming ability in a malignant xeroderma pigmentosum cell line. | |||
T9588 | JI130 | Others | |
JI130 is able to impair the ability of Hes1 to repress transcription. JI130 treatment significantly reduced tumor volume in a murine pancreatic tumor xenograft model. | |||
T5828 | MS21570 | GPR | |
MS21570 as a GPR171 antagonist based on its ability to block,with an IC50 of 220 Nm,that reduces anxiety-like behavior and fear conditioning in mice. | |||
T4351 | DAMGO | Dagol,DAGO,RX-783006 | Opioid Receptor |
DAMGO (DAGO) is an opioid receptor agonist with the ability to affect the locomotive activity in rodents. Possible analgesic agent due to μ-opiod receptor interaction. | |||
T6844 | GGTI298 Trifluoroacetate | GGTI 298,GGTI 298 TFA salt | Apoptosis , Transferase , Ras |
GGTI298 Trifluoroacetate (GGTI 298 TFA salt) is a geranylgeranyltransferase I inhibitor with ability to arrest human tumor cells in the G1 phase of the cell cycle and induce apoptosis. | |||
T22661 | CHM-1 | Apoptosis , Others , Microtubule Associated | |
CHM-1 is an inducer of apoptosis, and displays potent antitumor ability in human hepatocellular carcinoma by activation of Cdc2 kinase activity. CHM-1 inhibits tubulin polymerization in vitro and in vivo. | |||
T3059 | ALK-IN-1 | AP26113,Brigatinib,AP26113-analog | EGFR , IGF-1R , ALK |
ALK-IN-1 (AP26113) is a potent ALK inhibitor with IC50 of 0.62 nM in a cell-free assay, demonstrated ability overcome Crizotinib resistance mediated by a L1196M mutation. Phase 2. | |||
T3074 | CHIR 98024 | CHIR98014 | GSK-3 , S6 Kinase |
CHIR 98024 is a potent GSK-3α/β inhibitor with IC50 of 0.65 nM/0.58 nM in cell-free assays, with the ability to distinguish GSK-3 from its closest homologs Cdc2 and ERK2. | |||
T41277 | PACMA 31 | Others | |
PACMA 31 is an irreversible and covalent inhibitor of protein disulfide isomerase (PDI) with an IC50 of 10 μM. PACMA 31 significantly suppresses ovarian tumor growth and exhibits tumor targeting ability. | |||
T10835L1 | Cletoquine hydrochloride | Cletoquine hydrochloride( 4298-15-1 Free base) | Influenza Virus , Parasite |
Cletoquine hydrochloride is a major active metabolite of Hydroxychloroquine. Cletoquine hydrochloride is a Chloroquine derivative and exhibits the ability to against the chikungunya virus (CHIKV). Cletoquine hydrochlorid... | |||
T10789 | Chitosan oligosaccharide | COS | AMPK |
Chitosan oligosaccharide (COS) is an oligomer of β-(1→4)-linked D-glucosamine. It has the ability to activate AMPK and simultaneously inhibit inflammatory signaling pathways, including NF-κB and MAPK. | |||
T9379 | L-Threonic acid magnesium salt | Others | |
L-Threonic acid magnesium salt (L-TAMS) increases synapse density and memory ability in both aged rats and late stage Alzheimer’s disease (AD) model mice. | |||
T5830 | SKLB-23bb | HDAC | |
SKLB-23bb is an orally bioavailable HDAC6-selective inhibitor and also has microtubule-disrupting ability. | |||
T39817 | Msr-Ratio | Msr-green,Msr-Ratio | Others |
Msr-Ratio (Msr-green) (Msr-green) is a ratiometric fluorescent probe specifically designed for the detection of methionine sulfoxide reductase (MSR) activity. It has an excitation wavelength of 375 nm and an emission wav... | |||
T78525 | IRG1-IN-1 | Others | |
IRG1-IN-1 is an itaconic acid derivative with the ability to inhibit the activity of Immune Response Gene 1 (IRG1) and is suitable for use in the field of cancer, inflammation and autoimmune disease research. | |||
T11600 | IBR2 | Isoquinoline | DNA/RNA Synthesis |
IBR2 (Isoquinoline) is a potent and specific RAD51 inhibitor known for its ability to suppress RAD51-mediated DNA double-strand break repair. By interfering with RAD51 multimerization, accelerating proteasome-mediated RA... | |||
T35362 | NSC622608 | Others | |
NSC622608 is a small-molecule ligand for V-domain Ig suppressor of T-cell activation (VISTA) which is an immune checkpoint that affects the ability of T-cells to attack tumors. | |||
T40495 | Elastase from porcine pancreas | EC 3.2.1.35 | Others |
Porcine pancreatic elastase is a serine protease composed of a single polypeptide chain with 240 amino acid residues. It has the ability to hydrolyze polypeptides and proteins, and can induce emphysema in hamsters. | |||
T9909 | Pertuzumab | EGFR | |
Pertuzumab (anti-HER2) a humanized monoclonal antibody and the first in the class of agents called the HER2 dimerization inhibitors impairs the ability of HER2 to bind to other members of the HER family. | |||
T77288 | KKII5 | Lipoxygenase | |
KKII5 is a potent inhibitor of the lipoxygenase LOX-1 with an IC50 of 19 μM.KKII5 inhibits lipid peroxidation and enhances the ability of the active centers of some compounds to receive electrons. | |||
T77340L | AB21 HCl | Sigma receptor | |
AB21 HCl is a selective antagonist of the σ1 receptor, with Kis of 13 nM for σ1 receptor and 102 nM for σ2 receptor. AB21 HCl is known for its ability to reduce mechanical hypersensitivity. | |||
T7549 | Talnetant | SB 223412 | Neurokinin receptor |
Talnetant (SB 223412) is a selective, competitive, brain-penetrant NK3 receptor antagonist with the ability to modulate mesolimbic and mesocortical dopaminergic neurotransmission | |||
T22963 | McN-A 343 | AChR | |
McN-A 343 is a selective M1 muscarinic agonist known for its ability to stimulate muscarinic transmission in sympathetic ganglia. It has been found to effectively reduce inflammation and oxidative stress in experimental ... | |||
T60644 | SJ000063181 | TGF-beta/Smad | |
SJ000063181 is a potent activator of BMP signaling, exhibiting an EC50 of ≤1 μM. It serves as a valuable chemical probe for BMP signaling analysis, owing to its ability to penetrate zebrafish embryos. | |||
T5152 | MKT-077 | MKT 077,FJ-776,MKT077 | HSP |
MKT-077 (FJ-776) is a cationic rhodacyanine dye that demonstrates antiproliferative activity against cancer cell lines (EC50s: 1.4-2.2 μM in vitro) through its ability to inhibit members of the Hsp70 family of molecular ... | |||
T13947 | Tween 80 | Others | |
Tween 80 is a nonionic surfactant and emulsifier that reduces bacterial adherence and inhibits biofilm formation. Tween 80 is widely used as a co-solvent in pharmacology experiments because of its ability to enhance the ... | |||
T16962 | SW-100 | HDAC | |
SW-100 is a selective histone deacetylase 6 inhibitor (IC50: 2.3 nM). It also shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. SW-100 displays an obviously improved ability to cross the... | |||
T6040 | Aloxistatin | E64d,Loxistatin,E64c ethyl ester | SARS-CoV , Cysteine Protease |
Aloxistatin (E64d) is an inhibitor of cysteine protease with blood platelet aggregation inhibiting activity. Aloxistatin is an irreversible, membrane-permeable inhibitor of lysosomal and cytosolic cysteine proteases with... | |||
T50075 | 3,5-dimethyl-4-phenyl-1,2-oxazole | Others | |
3,5-dimethyl-4-phenyl-1,2-oxazole is a heterocyclic compound used as a molecular structural unit. It has anti-inflammatory, anti-tumor, anti-bacterial and anti-fungal activity, as well as the ability to modulate the immu... | |||
T9945 | MNK8 | 3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione | STAT |
MNK8 (3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione) is a potent STAT3 inhibitor that reduces the ability of STAT3 to bind to DNA and also has a good growth inhibition effect on liver cancer cells [1]. | |||
T35407 | Ζ-Stat | PKC | |
ζ-Stat (NSC37044), a specific and atypical inhibitor of PKC-ζ with an IC50 of 5 μM, demonstrates the ability to inhibit proliferation and induce apoptosis in melanoma cell lines, exhibiting antitumor activity in vitro[1]... | |||
T9908 | Pembrolizumab | PD-1/PD-L1 | |
Pembrolizumab is a humanized monoclonal antibody inhibiting the PD-1 receptor and the first in the class of agents called the HER2 dimerization inhibitors that impairs the ability of HER2 to bind to other members of the ... | |||
T60129 | MT189 | Antiproliferative agent-14 | Microtubule Associated |
MT189 (Antiproliferative agent-14) is a potent tubulin polymerization inhibitor, with an IC50 of 3.41 μM. Antiproliferative agent-14 has excellent antiproliferative activity. Antiproliferative agent-14 possess the abilit... | |||
T1342 | 3-Chloropropiophenone | Others | |
3-Chloropropiophenone (CPP) is a synthetic compound that is used in the synthesis of organic reagents, pharmaceuticals, and other products. It has the ability to inhibit certain enzymes (e.g. cytochrome P450) and inhibit... | |||
T15259 | Evatanepag | CP-533536 free acid | Prostaglandin Receptor |
Evatanepag (CP-533536 free acid) is an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation with EC50 of 0.3 nM.CP-533536 demonstrated the ability to heal fractures when administered l... | |||
T16686 | Pyr10 | TRP/TRPV Channel | |
Pyr10 is a pyrazole derivative and a selective TRP cation 3 inhibitor. Pyr10 has the ability to distinguish between receptor-operated TRPC3 and native stromal interaction molecule 1 (STIM1)/Orai1 channels. Pyr10 inhibits... | |||
T9651 | PD-1/PD-L1-IN-9 | PD-1/PD-L1 | |
PD-1/PD-L1-IN-9, with an IC50 of 3.8 nM, is a potent and orally active inhibitor of the PD-1/PD-L1 interaction. It enhances the immune cells' ability to kill tumor cells and demonstrates significant antitumor activity in... | |||
T9928 | Ranibizumab | VEGFR | |
Ranibizumab is a humanized monoclonal antibody fragment designed to target and inhibit vascular endothelial growth factor (VEGF), including VEGF110, VEGF121, and VEGF165. Ranibizumab's ability to selectively target and n... | |||
T8914 | MFCD01827729 | ETHYL 2-AMINO-4-(4-METHYLPHENYL)-3-THIOPHENECARBOXYLATE | Others |
MFCD01827729 (ETHYL 2-AMINO-4-(4-METHYLPHENYL)-3-THIOPHENECARBOXYLATE), also known as EMTPC, is a derivative of the amino acid thiophene, a heterocyclic aromatic compound. EMTPC has been investigated for its potential as... | |||
T77332 | TV 3279 | BCL , PKC | |
TV 3279 is a novel ChE-MAI inhibitor , and the neuroprotective properties depend on their ability to induce the anti-apoptotic proteins PKC, Bcl-2, Bcl-x, and SOD, and to block the nuclear translocation of the pro-apopto... | |||
T8909 | MFCD01917484 | ETHYL 2-AMINO-4-(4-METHOXYPHENYL)-3-THIOPHENECARBOXYLATE | Others |
MFCD01917484 (ETHYL 2-AMINO-4-(4-METHOXYPHENYL)-3-THIOPHENECARBOXYLATE) is a derivative of thiophene that possesses a variety of properties, including the ability to act as a ligand, catalyst and photosensitizer. It has ... | |||
T9229 | Pim-1/2 kinase inhibitor 1 | Pim | |
Pim-1/2 Kinase Inhibitor 1, an orally active inhibitor, impedes the action of Pim kinases by preventing their ability to phosphorylate peptides. It particularly inhibits the phosphorylation of 4E-BP1 and p27 Kip1 by Pim ... | |||
T23394 | SR 57227A | SR 57227 hydrochloride | 5-HT Receptor |
SR 57227A (SR 57227 hydrochloride) is a potent, orally active and selective 5-HT3 receptor agonist. It with ability to cross the blood brain barrier. It has affinities (IC50) varying between 2.8 and 250 nM for 5-HT3 rece... | |||
T8772 | Sumaresinolic Acid | Others | |
Sumaresinolic Acid is a natural lignan found in a variety of plants such as flaxseed, sesame and wheat bran and is a secondary metabolite of plants. It has been widely studied for its potential health benefits, including... | |||
T11093 | DPPH | 2,2-Diphenyl-1-picrylhydrazyl | Others |
DPPH (2,2-Diphenyl-1-picrylhydrazyl) is a cell-permeable, stable free radical that is commonly used to evaluate the ability of compounds to act as free radical scavengers or hydrogen donors and to measure the antioxidant... | |||
T16538 | PIN1 inhibitor API-1 | Others | |
PIN1 inhibitor API-1 is a specific Pin1 inhibitor (IC50: 72.3 nM). PIN1 inhibitor API-1 retains the active conformation of pXPO5 and restores the ability of pXPO5 to transport pre-miRNAs from the nucleus to cytoplasm, th... |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T4S0094 | Hydroxygenkwanin | Luteolin 7-methylether,7-O-Methylluteolin | Antioxidant |
1. Hydroxygenkwanin (Luteolin 7-methylether) possesses significant the antioxidative activity . 2. Hydroxygenkwanin has cytotoxicity, may be an effective natural product to treat glioma, and the combination of Apigenin a... | |||
T3S1416 | Decursin | Decursinol angelate,(+)-Decursin | Apoptosis , PKC |
1. Decursin (Decursinol angelate) is able to attenuate kainic acid-induced seizures and could have potential as an antiepileptic drug. 2. Decursin exhibits hepatoprotective effects , potentially by inhibiting the TGF-β1 ... | |||
T3845 | (+)-Gallocatechin | Gallocatechol,D-Gallocatechin | Others |
(+)-Gallocatechin (Gallocatechol) possesses free radical scavenging ability. (+)-Gallocatechin has moderate affinity to the human cannabinoid receptor. | |||
T41122 | 1,3-Dihydroxyacetone | Endogenous Metabolite | |
1,3-Dihydroxyacetone is the main active ingredient in sunscreen tanning skin care preparations, an important precursor for the synthesis of a variety of fine chemicals, and a food additive that can be produced on an indu... | |||
T3828 | (-)-Gallocatechin | (2S,3R)-gallocatechin,(−)-GC | Others |
(-)-Gallocatechin ((−)-GC) has free radical scavenging ability and moderate affinity to the human cannabinoid receptor. | |||
T2728 | Limonin | Dictamnolactone,Limonoic acid 3,19:16,17 dilactone,Obaculactone,Citrolimonin | Apoptosis , HIV Protease , Endogenous Metabolite |
Limonin (Citrolimonin) is a triterpenoid enriched in citrus fruits, which has antivirus and antitumor ability. | |||
T2987 | (-)-Epigallocatechin | l-Epigallocatechin,Epigallocatechin,EGC | MMP , Autophagy |
(-)-Epigallocatechin, the predominant flavonoid in green tea, possesses the unique ability to attach to unfolded native polypeptides, thereby inhibiting their transformation into amyloid fibrils. | |||
T7966 | 3-O-Ethyl-L-ascorbic acid | Tyrosinase | |
3-O-Ethyl-L-ascorbic acid is a cosmetic tyrosinase inhibitor with whitening ability and is a stabilized vitamin C derivative. It also has antioxidant properties. | |||
T10835 | Cletoquine | Desethylhydroxychloroquine | Parasite , Antifection |
Cletoquine is a major active metabolite of Hydroxychloroquine. Cletoquine has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune disease treatme... | |||
T4S0590 | Columbin | Phospholipase , COX , Parasite | |
1. Columbin has anti-inflammatory activity. 2. Columbin has chemopreventive ability against human colon cancer. 3. Columbin inhibits PLA2 hydrolysis of ghost RBC in a dose-dependent fashion. | |||
T5S0777 | Phellodendrine chloride | Others | |
Phellodendrine chloride has anti-nephritic activity, may be due to its ability to inhibit the proliferation or the migration of macrophages and cytotoxic T lymphocytes in the glomeruli. | |||
T4S1519 | Pseudoginsenoside RT5 | Others | |
1. Pseudoginsenoside RT5 has anti-epilepsy, anti-depressant activity by promoting nerve growth and improve cognitive ability. 2. Pseudoginsenoside RT5 has anti-bacterial, anti-tumor and anti-malaria activities. | |||
T6624 | Oxytetracycline Dihydrate | Terramycin Dihydrate | Others , Endogenous Metabolite , Antibacterial , Antibiotic , HSV |
Oxytetracycline Dihydrate (Terramycin Dihydrate) is a prescription antibiotic, interfering with the ability of bacteria to produce essential proteins. | |||
T2A2509 | Laurocapram | Tranzone,Azone,N-Lauryl caprolactam,N-0252,N-Dodecylcaprolactam | Others |
Laurocapram (N-Lauryl caprolactam) is a percutaneous enhancer. Upon application to the skin, laurocapram interacts with lipids in the stratum corneum and may enhance the ability of the skin to absorb a hydrophilic chemic... | |||
T3949 | Myristic acid | Crodacid,Tetradecanoic acid,n-Tetradecanoic acid | Others , Endogenous Metabolite |
Myristic acid (Crodacid) , a 14 carbon saturated fatty acid, is a rare molecule in cells and is a substrate of some fatty acid desaturases. This compound has the ability to acylate proteins by covalently binding to the N... | |||
T6S0781 | Phellodendrine | Phallodendrin | Others , NF-κB , Akt |
1. Phellodendrine (Phallodendrin) has anti-nephritic activity, may be due to its ability to inhibit the proliferation or the migration of macrophages and cytotoxic T lymphocytes in the glomeruli. | |||
T5746 | Dictamine | Dictamnine,Dectamine | Apoptosis , Anti-infection , Antibacterial , Antifungal |
Dictamine (Dectamine) shows anticholinesterase, anti-inflammatory, mutagenic, and has antimicrobial activity against bacteria and fungi. It has the ability to exert cytotoxicity in human cervix, colon, and oral carcinoma... | |||
T19792 | 1,3,7-Trimethyluric acid | Others | |
1,3,7-Trimethyluric acid is a purine alkaloid that occurs as a minor metabolite of caffeine in humans. As an antioxidant, it has shown an ability to scavenge hydroxyl radicals as well as protective potential against lipi... | |||
TQ0302 | Thapsigargin | Apoptosis , SARS-CoV , Calcium Channel | |
Thapsigargin is a natural product, an inhibitor of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) and an endoplasmic reticulum stress inducer. Thapsigargin increases cytoplasmic calcium concentration by blocking ... | |||
T19278 | Dicaprylyl carbonate | Dimethyl carbonate | Others |
Dicaprylyl carbonate (Dimethyl carbonate) is a solid fat derived from plants and a dry emollient. Dimethyl carbonate has good skin compatibility and comprehensive properties, such as a sunscreen filter with the ability t... | |||
T2S0265 | Robinin | NSC 9222 | TLR |
Flavone glycoside from Robinia with antibacterial and diuretic properties; derived from kaempferol.The ability of robinin to reverse the multidrug resistance of the human colon cancer cell line Colo 320 expreβing MDR1/LR... | |||
TN2244 | Sulfuretin | NF-κB , Autophagy | |
Sulfuretin is a potent anti-oxidant, has protective effect against t-BHP-induced oxidative damage in human liver-derived HepG2 cells is attributable to its ability to scavenge ROS and up-regulate the activity of HO-1 thr... | |||
T3763 | Fumaric acid | Lichenic acid,Fumarate,2-Butenedioic acid,Trans-Butenedioic acid,Donitic acid,Allomaleic acid | Endogenous Metabolite |
Fumaric acid (2-Butenedioic acid) attenuates the eotaxin-1 expression in TNF-α-stimulated fibroblasts by suppressing p38 MAPK-dependent NF-κB signaling. Fumaric acid has recently been identified as an oncometabolite or a... | |||
T3800 | Typhaneoside | Aervitrin | Others , Autophagy |
Typhaneoside (Aervitrin) is a flavonoid glycoside plant extract with potential ability to treat primary dysmenorrhea through the Shaofu Zhuyu decoction. | |||
T5S1262 | Methylophiopogonanone A | Others | |
1. Methylophiopogonanone A has anti-inflammatory and anti-oxidative properties. 2. Methylophiopogonanone A has therapeutic potential against cerebral I/R injury through its ability to attenuate BBB disruption by regulati... | |||
T2S2108 | Coixol | 6-methoxybenzoxazolone,6-MBOA,6-Methoxy-2-benzoxazolinone,MBOA | Others , Antibacterial |
1. Coixol (MBOA) acts as a central muscle relaxant with an anti-convulsant effect. 2. Coixol interacts with the pituitary to stimulate reproduction in voles. 3. Coixol has the ability to interact with FSH to stimulate fo... | |||
T3402 | 20(S)-Ginsenoside Rg3 | 20(S)-Ginsenoside-Rg3,Rg3,20S-Ginsenoside Rg3,Ginsenoside Rg3,S-Ginsenoside Rg3 | EGFR , Beta Amyloid , Potassium Channel , NF-κB , COX , Sodium Channel , Endogenous Metabolite |
20(S)-Ginsenoside Rg3 (Rg3) possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells. It inhibits the proliferation of human umbilical vein endothelial c... | |||
T2897 | (Rac)-Shikonin | (±)-Shikonin,Alkanet extract,Anchusin,Anchusa acid | Others |
(Rac)-Shikonin (Anchusin) is a natural red naphthoquinone pigment, has antimicrobial, anti-tumor, and anti-inflammatory effects; a purified shikonin preparation is widely used for the production of medicinals, cosmetics,... | |||
T0522 | Diammonium Glycyrrhizinate | Glycyrrhizin | Dehydrogenase |
Diammonium Glycyrrhizinate (Glycyrrhizin) , an extensively used anti-inflammatory agent, is isolated from the licorice root. It is metabolized to glycyrrhetinic acid, which inhibits 11-β-hydroxysteroid dehydrogenase and ... | |||
T4958 | (-)-Alkannin | Alkannin,Shikonin | Apoptosis , PI3K |
(-)-Alkannin (Shikonin) is a natural red naphthoquinone pigment, has antimicrobial, anti-tumor, and anti-inflammatory effects; a purified shikonin preparation is widely used for the production of medicinals, cosmetics, a... | |||
T7190 | Actein | Apoptosis , Akt , JNK , Autophagy | |
Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis, it also can prevent oxidative damage to osteoblasts in osteoporotic patients. Actein's ability to pathways in... | |||
T0926 | Azelaic acid | Finacea,Azelex,Nonanedioic acid,Anchoic acid | Others , DNA/RNA Synthesis , Endogenous Metabolite |
Azelaic acid (Anchoic acid) is a component of hair and skin conditioners and is produced by the ozonolysis of oleic acid. Azelaic acid has bacteriostatic activity against Propionibacterium acnes and Staphylococcus epider... | |||
TL0004 | FERULIC ACID METHYL ESTER | Methyl ferulate,Methyl 4'-hydroxy-3'-methoxycinnamate | p38 MAPK , Autophagy |
FERULIC ACID METHYL ESTER (Methyl ferulate) is a hydroxycinnamic acid that is abundant in plants and originally derived from giant fennel (F. communis). This naturally-occurring phenolic has antioxidant activities that p... | |||
TWS1977 | Kamebakaurin | Kamebakaurine | NF-κB |
1. Kamebakaurin (Kamebakaurine) has the ability to protect the liver from APAP-induced hepatotoxicity, presumably by both inhibiting the inflammatory response and oxidative stress. 2. Kamebakaurin inhibits the expression... | |||
TN1979 | Neocnidilide | Antifungal | |
Neocnidilide is an alkyl phthalate derived from Rhizoma Ligustici Chuanxiong with the ability to inhibit the growth of mycotoxin-producing fungi and to kill insects.The LC50 value of Neocnidilide against D. melanogaster ... | |||
T2S1008 | Oxysophoridine | Sophoridine N-oxide | Apoptosis , Antioxidant |
Oxysophoridine (Sophoridine N-oxide) has a protective effect on focal cerebral ischemic injury through antioxidant and anti-apoptotic mechanisms; it may be a potential neuroprotective agent for cerebral ischemia injury, ... | |||
T5S2347 | Deoxyshikonin | Arnebin 7 | Others , HIF/HIF Prolyl-Hydroxylase , Antibacterial |
1. Deoxyshikonin (Arnebin 7) may be a new drug candidate for wound healing and treatment of lymphatic diseases. 2. Deoxyshikonin enhances the ability of human dermal lymphatic microvascular endothelial cells (HMVEC-dLy) ... | |||
T3606 | γ-Oryzanol | Gamma-Oryzanol,Oliver,Gammariza | DNA Methyltransferase |
γ-Oryzanol (Gamma-Oryzanol) is a natural nutrient extract isolated from rice bran oil that contains a mixture of sterols and ferulic acids, which may aid in the destruction of free radicals in the skin. It has recently b... | |||
T4518 | Licochalcone D | ERK , NF-κB | |
Licochalcone D may be a potential drug for human melanoma treatment by inhibiting proliferation, inducing apoptosis via the mitochondrial pathway and blocking cell migration and invasion. Licochalcone D has cardioprotect... | |||
T25664 | Lepidiline A | Macaline A | Others |
Lepidiline A (Macaline A) is a flavonoid lignin with anti-inflammatory activity. Lepidiline A showed cytotoxic activity against HL-60 cells with IC50 of 32.3 μM. It is the active ingredient of Lepidium meyenii Walpers, a... | |||
T4S0878 | Prunetin | Prunusetin | ERK , Dehydrogenase , NF-κB |
1. Prunetin (Prunusetin) significantly reduces serum levels of inflammatory cytokines and mortality in mice challenged with lipopolysaccharide. 2. Prunetin mediates anti-obesity/adipogenesis effects by suppressing obesit... | |||
TN4627 | Naringin 4'-glucoside | Others | |
Naringin 4'-glucoside has antioxidant ability. | |||
TN4336 | Isothymusin | Antifection | |
Isothymusin( MIC= 200 microg/mL) exhibits inhibition activity against Mycobacterium tuberculosis. It ( IC50=7.7 microg/mL ) exhibits antioxidant activity against the radical scavenging ability of DPPH. | |||
T40667 | L-Azatyrosine | ||
L-Azatyrosine, an antitumor antibiotic derived from Streptomyces chibaensis, exhibits the ability to restore the normal phenotypic behavior of transformed cells that carry oncogenic Ras genes. | |||
T39385 | 15a-Hydroxy-3,11,23-trioxo-lanost-8,20-dien-26-oic acid | ||
15a-Hydroxy-3,11,23-trioxo-lanost-8,20-dien-26-oic acid is a Lanostane triterpenoid compound with the ability to inhibit NO production in LPS-induced microglia. | |||
T40741 | Dracorhodin | ||
Dracorhodin, the primary constituent found in the sanguis draconis extract, is a flavylium compound classified within the anthocyanin family. Notably, dracorhodin possesses the ability to elicit vasodilation. | |||
TN3612 | Caulophine | Others | |
Caulophine has the ability to protect cardiomyocytes from oxidative and ischemic injury through an antioxidative mechanism. | |||
T80867 | Villocarine A | ||
Villocarine A, an indole alkaloid with natural vasorelaxant properties [1], is a chemical compound known for its ability to relax blood vessels. | |||
T40924 | Tellimagrandin II | Eugeniin | |
Tellimagrandin II (Eugeniin) is the initial intermediate in the 4 C 1 -glucose derived series of ellagitannins. Additionally, it possesses the ability to inhibit antibiotic resistance exhibited by drug-resistant Staphylo... | |||
TN4527 | Methyl 3-(2,4-dihydroxyphenyl)propionate | Others | |
Methyl 3-(2,4-dihydroxyphenyl)propionate has inhibitory effects on tyrosinase, antioxidant ability, and lightening effect of ultraviolet B (UVB)-induced hyperpigmentation. | |||
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カタログ番号 | 製品名 | Species | Expression System |
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TMPY-04180 | PfLDH Protein, P. falciparum, Recombinant (His) | P. falciparum | E. coli |
Plasmodium falciparum lactate dehydrogenase (PfLDH) is a key enzyme for energy generation of malarial parasites and is considered to be a potential antimalarial target. The ability of PfLDH- or PfIDEh-based immuno-PCR as... | |||
TMPJ-00651 | CD155/PVR Protein, Human, Recombinant (aa 21-343, His) | Human | HEK293 Cells |
Poliovirus Receptor (PVR) is a 70 kDa type I transmembrane single-span glycoprotein that belongs to the nectin-like (Necl) family and was originally identified based on its ability to mediate the cell attachment and entr... | |||
TMPY-03650 | BirA Protein, E. coli, Recombinant (His & MBP) | E. coli | E. coli |
The enzyme BirA is a key reagent because of its ability to biotinylate proteins at a specific residue in a recognition sequence. This enzyme is used to biotinylate the C termini of membrane proteins, allowing these prote... | |||
TMPJ-01204 | TPSAB1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Tryptases are serine proteases with trypsin-like specificity. Together with chymases and Cathepsin G, tryptases are important players in mast cell mediation of inflammatory and allergic responses. Tryptase alpha/beta-1(T... | |||
TMPY-01280 | FOLR2 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Folate receptor beta, also known as Folate receptor 2, FBP, and FOLR2, is a member of the folate receptor family. FOLR2 is expressed in placenta and hematopoietic cells. The expression of FOLR2 is increased in malignant ... | |||
TMPY-06983 | IFN gamma Protein, Human, Recombinant (E. coli) | Human | E. coli |
IFN gamma, also known as IFNG, is a secreted protein that belongs to the type II interferon family. IFN gamma is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, ... | |||
TMPJ-00375 | HGF Protein, Human, Recombinant (His) | Human | HEK293 Cells |
HGF, is a pleiotropic protein in the Plasminogen subfamily of S1 peptidases and contains 4 kringle domains, 1 PAN domain and 1 peptidase S1 domain. HGF is secreted as an inactive 728 amino acid (aa) single chain propepti... | |||
TMPH-02552 | BMP3 Protein, Mouse, Recombinant (Myc) | Mouse | E. coli |
Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification. | |||
TMPH-01305 | ER beta Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) |
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.; Lacks ... | |||
TMPH-01304 | ER beta Protein, Human, Recombinant (E. coli, His) | Human | E. coli |
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.; Lacks ... | |||
TMPH-03719 | YopH Protein, Yersinia enterocolitica, Recombinant (His & Myc) | Yersinia enterocolitica | E. coli |
Essential virulence determinant. This protein is a protein tyrosine phosphatase. The essential function of YopH in Yersinia pathogenesis is host-protein dephosphorylation. It contributes to the ability of the bacteria to... | |||
TMPH-00298 | Resistin Protein, Bovine, Recombinant (His) | Bovine | E. coli |
Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. Potentially links obesity to diabetes. Resistin Protein, Bovine, Recombinant (His) is expressed in E. coli expression system ... | |||
TMPH-03100 | PMAP-23 Protein, Pig, Recombinant (His & SUMO) | Sus scrofa (Pig) | E. coli |
Exerts antimicrobial activity against both Gram-positive and negative bacteria at concentrations of 2-16 micro molar. Its activity appears to be mediated by its ability to damage bacterial membranes. PMAP-23 Protein, Pig... | |||
TMPY-03465 | Flagellin Protein, Listeria monocytogenes, Recombinant (His) | Listeria monocytogenes | E. coli |
The role of flagella and motility in the attachment of the foodborne pathogen Listeria monocytogenes to various surfaces is mixed with some systems requiring flagella for an interaction and others needing only motility... | |||
TMPH-03173 | OprF Protein, Pseudomonas aeruginosa, Recombinant (His) | Pseudomonas aeruginosa | E. coli |
Has porin activity, forming small water-filled channels. Also has a structural role in determining cell shape and ability to grow in low-osmolarity medium. OprF Protein, Pseudomonas aeruginosa, Recombinant (His) is expre... | |||
TMPK-01539 | HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Monomer Protein, Human, MHC (His & Avi), Biotinylated | Human | HEK293 Cells |
NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses,... | |||
TMPH-03210 | TFPI Protein, Rabbit, Recombinant (E. coli, His) | Rabbit | E. coli |
Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability t... | |||
TMPK-01448 | HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Tetramer Protein, Human, MHC (E. coli, His & Avi) | Human | E. coli |
NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses,... | |||
TMPK-01543 | HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Monomer Protein, Human, MHC (His & Avi) | Human | HEK293 Cells |
NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses,... | |||
TMPK-01499 | HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) Tetramer Protein, Human, MHC (His & Avi) | Human | HEK293 Cells |
NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses,... | |||
TMPK-01513 | HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) Monomer Protein, Human, MHC (His & Avi), Biotinylated | Human | HEK293 Cells |
NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses,... | |||
TMPK-00030 | LAIR2 Protein, Human, Recombinant (Avi & His) | Human | HEK293 Cells |
The leukocyte-associated immunoglobulin-like receptor 2 (LAIR2) shows increased expression during pregnancy and its reduced expression is associated with pregnancy complications. Although LAIR2 was expressed in the human... | |||
TMPH-03600 | Glucosyltransferase-SI Protein, S. mutans serotype c, Recombinant (His & Myc) | Streptococcus mutans | E. coli |
Production of extracellular glucans, that are thought to play a key role in the development of the dental plaque because of their ability to adhere to smooth surfaces and mediate the aggregation of bacterial cells and fo... | |||
TMPK-01449 | HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Monomer Protein, Human, MHC (E. coli, His & Avi) | Human | E. coli |
NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses,... | |||
TMPK-01500 | HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) Monomer Protein, Human, MHC (His & Avi) | Human | HEK293 Cells |
NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses,... | |||
TMPK-01546 | HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Tetramer Protein, Human, MHC (His & Avi) | Human | HEK293 Cells |
NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses,... | |||
TMPK-01497 | HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled | Human | HEK293 Cells |
NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses,... | |||
TMPH-00627 | GAD-alpha Protein, E. coli, Recombinant (His) | E. coli | E. coli |
Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions... | |||
TMPH-03211 | TFPI Protein, Rabbit, Recombinant (His) | Rabbit | HEK293 Cells |
Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability t... | |||
TMPJ-01076 | FKBP4 Protein, Human, Recombinant (His) | Human | E. coli |
FKBP4 act as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. FKBP4 may play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone recepto... | |||
TMPH-01015 | BMP-3 Protein, Human, Recombinant (His) | Human | E. coli |
Growth factor of the TGF-beta superfamily that plays an essential role in developmental process by inducing and patterning early skeletal formation and by negatively regulating bone density. Antagonizes the ability of ce... | |||
TMPY-02480 | Chymotrypsin C Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Chymotrypsin C (abbreviated for CTRC), also known as caldecrin or elastase4, is a digestive enzyme of the peptidase S1 family. This enzyme is synthesized as an inactivate chymotrypsinogen. On cleavage by trypsin into two... | |||
TMPK-00248 | TRAIL R4/TNFRSF10D Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells |
TNF-related apoptosis inducing ligand (TRAIL) is a potential antitumor protein known for its ability to selectively eliminate various types of tumor cells without exerting toxic effects in normal cells and tissues. TRAIL... | |||
TMPJ-00765 | TDT Protein, Human, Recombinant (His) | Human | E. coli |
Terminal deoxynucleotidyl transferase (TdT) is a highly conserved vertebrate enzyme that possesses the unique ability to catalyze the random addition of deoxynucleoside 5'-triphosphates onto the 3'-hydroxyl group of a si... | |||
TMPH-02660 | Frataxin/FXN Protein, Mouse, Recombinant (His) | Mouse | P. pastoris (Yeast) |
Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress thr... | |||
TMPK-00249 | TRAIL R4/TNFRSF10D Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells |
TNF-related apoptosis inducing ligand (TRAIL) is a potential antitumor protein known for its ability to selectively eliminate various types of tumor cells without exerting toxic effects in normal cells and tissues. TRAIL... | |||
TMPK-00636 | BID Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Bid, BH3-interacting domain death agonist, was initially cloned based in its ability to interact with both Bcl-2 and Bax. Bid contains only the BH3 domain, which is required for its interaction with the Bcl-2 family prot... | |||
TMPJ-01429 | SARS-CoV-2 Guanine-N7 methyltransferase Protein (His) | SARS-CoV-2 | E. coli |
The nonstructural protein (nsp) 14 of SARS-CoV 2 was identified as a cap (guanine-N7)-methyltransferase (N7-MTase). Nsp14 of coronaviruses two different activities: an exoribonuclease activity acting on both ssRNA and ds... | |||
TMPH-03577 | Staphopain B Protein, S. aureus, Recombinant (GST) | Staphylococcus aureus | E. coli |
Cysteine protease that plays an important role in the inhibition of host innate immune response. Degrades host elastin, fibrogen, fibronectin and kininogen. Blocks phagocytosis of opsonised S. aureus by neutrophils and m... | |||
TMPJ-01377 | Testin Protein, Human, Recombinant (His) | Human | E. coli |
Testin belongs to the prickle/espinas/testin family. Testin contains three LIM zinc-binding domains and one PET domain, TES as a scaffold protein that may have a role in cell adhesion, cell spreading and in the reorganiz... | |||
TMPH-00077 | IAA17 Protein, Arabidopsis thaliana, Recombinant (His & Myc) | Arabidopsis thaliana | E. coli |
Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations. Repression is thought to result from the interaction with auxin response fac... | |||
TMPH-02505 | ENO1 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate. In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses. May ... | |||
TMPJ-01196 | ANGPTL8 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
The protein specifically promotes pancreatic beta cell proliferation and beta cell mass expansion, thereby improving glucose tolerance. It promotes pancreatic beta cell proliferation without insulin resistance. Also it a... | |||
TMPJ-00727 | PGK1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Phosphoglycerate kinase 1(PGK1) is an enzyme. It is mainly expressed in spermatogonia and Localized on the principle piece in the sperm. Its expression significantly decreased in the testis of elderly men. PGK1 involved ... | |||
TMPJ-00797 | LDHB Protein, Human, Recombinant (His) | Human | E. coli |
L-Lactate Dehydrogenase B Chain (LDH-B) is a member of the lactate dehydrogenase family that consists of three members, LDH-A, LDH-B and LDH-C; members of this family function as powerful markers for germ cell tumors. LD... | |||
TMPJ-00918 | HMGB2 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
High Mobility Group Protein B2 (HMGB2) belongs to the non-histone chromosomal high-mobility group protein family. Members of this family are chromatin-associated and widely spread in the nucleus of higher eukaryotic cell... | |||
TMPY-03980 | ECD Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells |
ECD, also known as ecdysoneless homolog, belongs to the SGT1 family. It is highly expressed in muscle and heart. ECD is a novel promoter of mammalian cell cycle progression. This function is related to its ability to re... | |||
TMPH-02661 | Frataxin/FXN Protein, Mouse, Recombinant (E. coli, His) | Mouse | E. coli |
Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress thr... | |||
TMPJ-00364 | LRRC32 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Leucine Rich Repeat Containing 32 (LRRC32), also known as Glycoprotein A Repetitions Predominant (GARP), has been postulated as a novel surface marker of activated T(regs). LRRC32 binds directly to the TGF-beta latency a... | |||
TMPJ-00565 | Mucin-15/MUC15 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Mucin-15 is a single-pass type I membrane protein member of the Mucin family. Mucins are a family of high molecular weight, heavily glycosylated proteins (glycoconjugates) produced by epithelial tissues in most metazoans... | |||
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A unique collection of 4533 pure natural products and their derivatives with known biological activity for drug discovery, pharmacological study, stem cell differentiation, fingerprint study and quality research, and can... | |||
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A unique collection of 449 compounds acting on immune-oncology therapeutic targets can be used for high throughput and high content screening; | |||
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210 macrocyclic compounds of known activity for high-throughput, high-content screening; | |||
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