| T9135 |
Epirosmanol
|
|
Others
|
|
Epirosmanol is a diterpenoid containing a lactone moiety. Epirosmanol is a very weakly basic (essentially neutral) compound (based on its pKa). |
| T5S0106 |
Peimisine
|
Ebeiensine |
RAAS
,
AChR
|
|
1. Peimisine (Ebeiensine) can affect M-receptor, excit β-receptor, restrain the release of internal calcium, and promote to releaseing nitrogen monoxidum in order to relax tracheal smooth muscle and relieve asthma. 2. Pe... |
| TN2356 |
Tetradehydropodophyllotoxin
|
Dehydropodophyllotoxin |
Others
,
Antifungal
|
|
Tetradehydropodophyllotoxin (Dehydropodophyllotoxin) has anti-tumor activity. |
| TN1531 |
Cratoxylone
|
|
Antifungal
|
|
Cratoxylone is derived from the bark of the Cochin tree and has anti-plasmodial activity and potential anti-tumor and antioxidant activity. |
| T8271 |
10Z-Nonadecenoic acid
|
|
Endogenous Metabolite
|
|
10Z-Nonadecenoic acid is a long-chain fatty acid with anti-tumor activity. |
| T4745 |
4-Carboxyquinoline
|
QUINOLINE-4-CARBOXYLIC ACID,4-Quinolinecarboxylic acid |
Others
,
Endogenous Metabolite
|
|
4-Carboxyquinoline (4-Quinolinecarboxylic acid) showed anti-tumor activity against L1210 leukemia and B16 melanoma. |
| T5726 |
Specneuzhenide
|
Nuezhenide |
Others
|
|
Specneuzhenide (Nuezhenide) is a phenol glycoside isolated from Ligustrum sinense. Specneuzhenide (Nuezhenide) possesses anti-tumor activity,has anti-angiogenic and vision improvement effects. |
| TN4991 |
Senkyunolide A
|
|
Others
|
|
Senkyunolide A is a natural product isolated from Ligusticum chuanxiong Hort, with anti-tumor activity. |
| T10117 |
3'-O-Acetylhamaudol
|
|
Others
|
|
3'- O- Acetylhamaudol, isolated from the roots of Angelica japonica, exhibits anti-tumor activity through dual actions, anti-angiogenesis and intestinal intraepithelial lymphocyte activation. |
| T3400 |
Bakuchiol
|
|
p38 MAPK
,
DNA/RNA Synthesis
,
Autophagy
|
|
Bakuchiol possesses anti-tumor,and anti-helmenthic properties. It has cytotoxic activity, mainly due to its DNA polymerase1 inhibiting activity. Bakuchiol has anti-bacterial activity against oral pathogens, has great pot... |
| T4S1519 |
Pseudoginsenoside RT5
|
|
Others
|
|
1. Pseudoginsenoside RT5 has anti-epilepsy, anti-depressant activity by promoting nerve growth and improve cognitive ability. 2. Pseudoginsenoside RT5 has anti-bacterial, anti-tumor and anti-malaria activities. |
| TN2337 |
Poricoic acid AM
|
|
|
|
Poricoic acid AM is a triterpenoid compound extracted from Poria cocos, demonstrating anti-tumor activity. |
| T8169 |
Decursinol
|
|
Others
|
|
Decursinol is isolated from the roots of Angelica Gigas with an antinociceptive effect. It also has anti-tumor and anti-metastasis activity. |
| TN1557 |
Decursinol angelate
|
|
ERK
,
VEGFR
,
PKC
,
JNK
|
|
Decursinol angelate has anti-tumor, anti-inflammatory, anti-oxidant, and hepatoprotective activities, it inhibits VEGF-induced angiogenesis via suppression of the VEGFR-2-signaling pathway; it also suppresses invasion an... |
| TN1459 |
Bufarenogin
|
3beta,12beta,14-Trihydroxy-11-oxo-5beta-bufa-20,22-dienolide |
ERK
,
MEK
,
PI3K
|
|
Bufarenogin (3beta,12beta,14-Trihydroxy-11-oxo-5beta-bufa-20,22-dienolide) is a bufadienolide isolated from parotoid gland secretions of the Cuban endemic toad Peltophryne fustiger. Bufarenogin shows anti-tumor activity. |
| TQ0118 |
Britannilactone
|
Desacetylinulicin |
Others
|
|
Britannilactone (Desacetylinulicin) is a sesquiterpene from Inula britannica with anti-inflammatory and anti-tumor activity.Britannilactone has been associated with this antimelanotic activity and can be used in studies ... |
| T3S1513 |
(20R)-Protopanaxadiol
|
Protopanaxadiol,20R-Protopanaxadiol,(20R)-Protopanaxdiol |
Others
,
Antibacterial
|
|
1. (20R)-Protopanaxadiol ((20R)-Protopanaxdiol) has the effect of anti-tumor through increasing the activity of body immunity, inhibiting tumor interstitial microvascular density and its proliferation activity, improving... |
| T3S0872 |
Paederoside
|
|
Antiviral
,
HBV
|
|
1. Paederoside is a potent deterrent against the beetle was isolated from the aphid . 2. Paederoside displays high anti-tumor promoting activity against the Epstein-Barr virus activation. |
| T5S1882 |
Songorine
|
Napellonine,Zongorine,Bullatine G |
Others
,
GABA Receptor
|
|
Songorine (Napellonine) shows favorable anti-tumor activity in preliminary pharmacological verification trials including cell proliferation and molecular docking assays. |
| T2744 |
Methyl Cholate
|
Cholic acid methyl ester |
Others
|
|
Methyl Cholate is the methyl ester form of cholic acid. Methyl Cholate is the methyl ester form of bile acid, which is a major bile acid produced by the liver and synthesized from cholesterol.Methyl Cholate has anti-infl... |
| T5660 |
Menthone
|
|
IL Receptor
,
TNF
,
NF-κB
,
Parasite
|
|
Menthone has anti-inflammary activity,, it can suppress the lipopolysaccharide (LPS)-induced proinflammatory cytokines, interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha),as well as nuclear factor k... |
| T3S0895 |
Spirostan-3-ol
|
Sarsaponin |
Others
|
|
Spirostan-3-ol (Sarsaponin) is a stereoisomer of Sarsasapogenin (S142505), a steroid glycoside isolated from plant materials. A saponin with with potential anti-tumor activity via apoptosis. |
| T4S21320 |
ISOGINKGETIN
|
4',4'''-Dimethylamentoflavone |
MMP
,
Others
|
|
1. ISOGINKGETIN (4',4'''-Dimethylamentoflavone), a compound derived from the leaves of Ginkgo biloba, to up-regulate adiponectin secretion with potency comparable to that of rosiglitazone, a known modulator of adiponecti... |
| T7984 |
2-Hydroxyflavanone
|
|
Others
|
|
2-Hydroxyflavanone is a naturally occurring flavonoid found in many plants and fruits. It has antioxidant, anti-inflammatory and anti-tumor activity, scavenging free radicals, reducing inflammation and inhibiting the gro... |
| TN7052 |
Crocin III
|
Crocetin-mono-(β-D-gentiobiosyl)-ester |
Others
|
|
Crocin III (Crocetin-mono-(β-D-gentiobiosyl)-ester) is a crocin derived from saffron (Crocus sutivus L.). Crocins inhibit the cell growth of tumor cells and have anti-inflammatory activity. |
| T13818 |
Phytohemagglutinin
|
PHA-M |
Apoptosis
|
|
Phytohemagglutinin (PHA-M) is a lectin, isolated from the red kidney bean , induces apoptosis via increasing proapoptotic protein Bax and activating caspases-3. Anti-tumor activity |
| T7990 |
9-hydroxy-4-androstene-3,17-dione
|
|
Others
|
|
9-hydroxy-4-androstene-3,17-dione is a steroid hormone. It has anti-tumor activity and can inhibit the growth of many types of cancer cells, including breast, prostate and lung cancer cells. |
| T15705 |
Laminaran
|
β-1,3-Glucan |
|
|
Laminaran is a β-1,3-glucan isolated from brown algae, often serving as a typical ligand for Dectin-1. It possesses anti-cancer, immune-modulating, and radiation-protective properties. Laminaran can be catalyzed by gluca... |
| TN1516 |
Cnidicin
|
|
NOS
,
NO Synthase
|
|
Cnidicin has anti-allergic and anti-inflammatory activity, it inhibits the degranulation of mast cell and the NO generation in RAW 264.7 cells(IC50 value, 7.5 microM). Cnidicin exhibits a significant inhibition on the pr... |
| T6S0117 |
Avicularin
|
Fenicularin |
ERK
|
|
Avicularin (Fenicularin) has anti-allergic, anti-inflammatory, hepatoprotective, antioxidant, anti-tumor and other activities. It ameliorates human hepatocellular carcinoma by modulating the activities of NF-κB(p65), COX... |
| T0968 |
Paclitaxel
|
Taxol,NSC 125973 |
Apoptosis
,
Microtubule Associated
,
Autophagy
|
|
Paclitaxel (Taxol) is a natural product and a microtubule polymer stabilizer. Paclitaxel has anti-tumor activity and causes cell death by inducing mitotic arrest, apoptosis, and cell autophagy. |
| TN1661 |
Ganoderic acid C2
|
|
Reductase
,
Histamine Receptor
,
Immunology/Inflammation related
|
|
Ganoderic acid C2 has anti-inflammatory,and anti-tumor-promoting activities. Ganoderic acid C2 can inhibit histamine release, it also has inhibitory effects on the induction of Epstein-Barr Virus early antigen. |
| Fr12277 |
4-Hydroxy-6-methylcoumarin
|
|
Others
|
|
4-Hydroxy-6-methylcoumarin (4-HMC) is a naturally occurring phenolic compound, a derivative of coumarin, found in a variety of plants, fungi, and bacteria. It has anti-inflammatory and anti-tumor activity.4-HMC is used a... |
| T3S1641 |
Esculentoside H
|
|
TNF
,
NF-κB
,
JNK
|
|
Phytolaccaceae has anti-tumor activity, the mechanism may be related to the capacity of Esculentoside H for TNF release. |
| T36715 |
Tetrac
|
Tetraiodothyroacetic acid,3,3',5,5'-Tetraiodothyroacetic acid |
Apoptosis
,
EGFR
|
|
Tetrac (Tetraiodothyroacetic acid) is a derivative of L-thyroxine (T4), a thyroxine integrin receptor antagonist.Tetrac induces antiproliferation by blocking EGFR-mediated cell signaling in colorectal cancer cells.Tetrac... |
| T6S1579 |
Monotropein
|
Monotropeine |
Others
|
|
1. Monotropein (Monotropeine) has antinociceptive action. 2. Monotropein has anti-apoptosis and anti-catabolic activity in chondrocytes. 3. Monotropein has anti-inflammatory action by inhibition of the expressions of inf... |
| T1034 |
Docetaxel
|
NSC 628503,RP-56976 |
Apoptosis
,
Microtubule Associated
,
Endogenous Metabolite
|
|
Docetaxel (RP-56976) is a semi-synthetic analog of paclitaxel, a microtubule depolymerization inhibitor (IC50=0.2 μM). Docetaxel attenuates the effects of bcl-2 and bcl-xL gene expression and exhibits apoptosis-inducing,... |
| T3897 |
Isoschaftoside
|
|
Anti-infection
,
Antifungal
|
|
Isoschaftoside is used as an intercrop due to its allelopathic inhibition of parasitism by Striga hermonthica, an obligate parasitic weed that can devastate the maize crop. Isoschaftoside has anti-tumor, antioxidant, and... |
| T3S0737 |
Flavokawain A
|
Flavokavain A |
Apoptosis
,
p38 MAPK
|
|
NSC-37445 has anti-tumor activity, such as inhibits growth of bladder tumor cells in a nude mice model , prevents the recurrence and progression of non-muscle-invasive urothelial cell carcinoma. NSC-37445 can significant... |
| T2P2806 |
Hederacolchiside A1
|
Raddeanoside R13 |
Apoptosis
,
ERK
,
MEK
,
Akt
,
PI3K
,
Parasite
,
mTOR
|
|
Hederacolchiside A1 (Raddeanoside R13) shows anti-leishmanial activity, it exhibits a strong antiproliferative activity on all stages of development of the parasite by altering membrane integrity and potential. Hederacol... |
| T2978 |
Mogroside V
|
|
AMPK
|
|
Mogroside V is a widely used sweetener, has in vitro AMPK activating effect, it also has anti-inflammatory potential in murine macrophages and a murine ear edema model, and has the potential to protect against LPS-induce... |
| T4672 |
Brevilin A
|
|
Apoptosis
,
Anti-infection
,
JAK
,
STAT
,
Autophagy
|
|
Brevilin A is a sesquiterpene lactone isolated from Centipeda minima, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells with anti-tumor activity. Brevilin A is a selective inhibitor of JAK-STAT si... |
| T6S0119 |
Dauricine
|
|
Apoptosis
,
Others
,
NF-κB
|
|
1. Dauricine has pulmonary toxicity, can produce pulmonary injury in CD-1 mice by the metabolism of Dauricine mediated by CYP3A. 2. Dauricinec can pass the blood-brain barrier, and that P-glycoprotein has an important ro... |
| T6S1256 |
Ruscogenin
|
|
NOS
,
NF-κB
,
NOD-like Receptor (NLR)
|
|
1. Ruscogenin has anti-inflammatory activity, suppressed zymosan A-evoked peritoneal total leukocyte migration in mice in a dose-dependent manner, 2. Ruscogenin inhibited adhesion of leukocytes to a human umbilical vein ... |
| TN1564 |
Delphinidin 3-glucoside chloride
|
Delphinidin-3-O-glucoside chloride |
Apoptosis
,
EGFR
|
|
Delphinidin 3-glucoside chloride (Delphinidin-3-O-glucoside chloride) is a dietary phenolic substance found in Hibiscus sabdariffa extracts. Delphinidin 3-glucoside chloride has antioxidant activity, induces pro-apoptoti... |
| TMA2008 |
3-Hydroxy-1,5-diphenyl-1-pentanone
|
|
|
|
(+)-3-Hydroxy-1,5-diphenyl-1-pentanone exhibits both immunomodulatory and anti-tumor activity. |
| T14330 |
Ascochlorin
|
Ilicicolin D |
STAT
|
|
Ascochlorin (Ilicicolin D), an isoprenoid antibiotic, primarily exerts its anti-tumor properties by inhibiting the STAT3 signaling pathway. It induces apoptosis and possesses anti-inflammatory activity[1][2][3]. |
| TN2926 |
3-Epicabraleahydroxylactone
|
|
Others
|
|
3-Epicabraleahydroxylactone has anti-tumor promoting effect, it has anti-carcinogenic activity by the inhibitory effect on the induction of Epstein-Barr virus early antigen(EBV-EA) by the tumor promoter. |
| T12093 |
Monascin
|
|
Others
|
|
Monascin is a kind of azaphilonoid pigments extracted from Monascus pilosus-fermented rice (red-mold rice),exhibits anti-tumor-initiating activity and anti-inflammatory activity . |
| TMA2576 |
Episappanol
|
|
IL Receptor
,
TNF
|
|
Episappanol has anti-inflammatory activity , it can significantly inhibit the secretion of the pro-inflammatory cytokines interleukin (IL-6) and tumor necrosis factor-alpha (TNF-α). |
