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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T38514 | PMEDAP | Others , HIV Protease | |
PMEDAP is a potent inhibitor of Moloney murine sarcoma virus (MSV)-induced tumor formation and associated mortality and an inhibitor of human immunodeficiency virus (HIV) replication. PMEDAP also has anti-murine cytomega... | |||
T40187 | GNF2133 | DYRK | |
GNF2133 is an effective and selective inhibitor of DYRK1A with IC50s of 6.2 nM. GNF2133 can be used in studies about type 1 diabetes. | |||
T36692 | Fanotaprim | DHFR | |
Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor. Fanotaprim inhibits the growth of T. gondii strains with a TgDHFR IC50 of 1.57 ± 0.11 nM and a hDHFR IC50 of 308 ± 71 nM and a hDHFR to TgDHFR selectivity ratio o... | |||
T8574 | SPHINX | Others | |
SPHINX is a new generation inhibitor of SPRK1 | |||
T5477 | ELQ-300 | Parasite | |
ELQ-300 is bioavailable antimalarial agent, acts as an inhibitor of the reductive (Qi) site of the cytochrome bc1 complex (cyt bc1) | |||
T41277 | PACMA 31 | Others | |
PACMA 31 is an irreversible and covalent inhibitor of protein disulfide isomerase (PDI) with an IC50 of 10 μM. PACMA 31 significantly suppresses ovarian tumor growth and exhibits tumor targeting ability. | |||
T29126 | VU0360172 | VU-0360172,VU 0360172 | GluR |
VU0360172 is a positive allosteric modulator of mGlu5 receptors (EC50 = 16 nM; Ki = 195 nM). | |||
T7149 | S29434 | NADPH , Autophagy | |
S29434 (NMDPEF) is a potent, competitiveinhibitor of quinone reductase 2 (QR2;IC50:5-16nM). | |||
T7156 | NIBR189 | EBI2/GPR183 | |
NIBR189 is a potent and selective antagonist of EBI2 (GPR183) receptor (IC50 of 11 and 15 nM for human and mouse EBI2 receptors, respectively) | |||
T9266 | Fatostatin | Lipid , Fatty Acid Synthase | |
Fatostatin is a specific inhibitor of SREBP activation, it impairs the activation of SREBP-1 and SREBP-2. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. | |||
T5345 | V-9302 | Others | |
V-9302 (V9302) is a competitive antagonist of transmembrane glutamine flux that selectively and potently targets the amino acid transporter ASCT2 (IC50: 9.6 uM). | |||
T8222 | Selpercatinib | LOXO-292 | c-RET |
Selpercatinib (LOXO-292) is a tyrosine kinase inhibitor with antineoplastic properties(IC50 of 14.0 nM, 24.1 nM, and 530.7 nM for RET (WT), RET (V804M) , and RET (G810R), respectively) | |||
T2014 | CCG-1423 | CCG1423 | LRRK2 , Rho , Ras |
CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription. | |||
T9521 | CHR-6494 TFA | Others | |
CHR-6494 TFA is a potent haspin inhibitor, with an IC50 of 2 nM. It inhibits histone H3T3 phosphorylation. CHR-6494 TFA induces the apoptosis of cancer cells, including melanoma and breast cancer. CHR-6494 TFA can be use... | |||
T8954 | ML179 | ML-179 | Others |
ML179 is a potent and selective inverse agonist of liver receptor homolog-1 (LRH1, NR5A2) with IC50 of 320 nM. | |||
T12079 | ML604440 | Proteasome | |
ML604440 is a cell permeable proteasome β1i (LMP2) subunit inhibitor. | |||
T1115 | Doxylamine succinate | Decapryn | Histamine Receptor |
Doxylamine Succinate is a pyridine derivate histamine H1 antagonist with pronounced sedative properties. Doxylamine succinate (Decapryn) competitively blocks the histamine H1 receptor and limits the typical allergic and ... | |||
T15249 | Estrogen receptor modulator 1 | Estrogen Receptor/ERR | |
Estrogen receptor modulator 1 causes regression of Tamoxifen-resistant, hormone-independent xenograft tumors. Estrogen receptor modulator 1 is an orally active and selective estrogen receptor modulator (SERM) (pIC50: 0.4... | |||
T9072 | Tuxobertinib | BDTX-189 | EGFR , HER , BTK , RIP kinase |
Tuxobertinib (BDTX-189) is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations(KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively). BDTX-189 exhibits anticancer activ... | |||
T10717 | Inobrodib | CBP-IN-1 | Epigenetic Reader Domain |
Inobrodib (CBP-IN-1) is a potent inhibitor of p300/CBP bromodomain. | |||
T4014 | CP-724714 | CP724714,CP 724714 | Apoptosis , EGFR |
CP-724714 (CP724714) is an effective and selective HER2/ErbB2 inhibitor (IC50: 10 nM), >640-fold selectivity against EGFR, Abl, InsR, PDGFR, IRG-1R, Src, VEGFR2, c-Met etc. | |||
T26619 | Amitivir | LY217896,LY 217896,LY-217896 | Others , Influenza Virus |
Amitivir (LY 217896) is an inosine monophosphate dehydrogenase inhibitor. Amitivir inhibits the replication of dividing MDCK cells. Amitivir was associated with asymptomatic rises in serum uric acid levels and was ineffe... | |||
T11279 | FGFR1/DDR2 inhibitor 1 | Discoidin Domain Receptor (DDR) , FGFR , Others | |
FGFR1/DDR2 inhibitor 1 is an inhibitor of discoindin domain receptor 2 (DDR2) and fibroblast growth factor receptor 1 (FGFR1), with IC50 values of 31.1 nM, 108.4 nM and 3.2 nM for FGFR1, KG-1, and DDR2, respectively. | |||
T12134 | MYCMI-6 | NSC354961 | Apoptosis , c-Myc |
MYCMI-6 (NSC-354961) is a potent and selective inhibitor of endogenous MYC:MAX protein interactions,reduces proliferation and induces massive apoptosis in tumor tissue from a MYC-driven xenograft tumor model without seve... | |||
T3100 | GSK-J4 | GSK J4 HCl | Apoptosis , Histone Demethylase |
GSK-J4 (GSK J4 HCl) is a potent H3K27me3 demethylase inhibitor, with IC50s of 8.6 μM and 6.6 μM towards KDM6B and KDM6A respectively. It is the first selective inhibitor of the H3K27 histone demethylase JMJD3 and UTX wit... | |||
T7535 | RGX-202 | β-GPA,3-Guanidinopropionic Acid | AMPK , PPAR |
RGX-202 (β-GPA) is a creatine analog that alters skeletal muscle energy expenditure. It reduces cellular ATP, creatine, and phosphocreatine levels and stimulates AMP-activated protein kinase (AMPK), activating PPARγ coac... | |||
T1290 | Oxiconazole nitrate | Ro 13-8996 | Others , Antibiotic , Antifection , Antifungal |
Oxiconazole nitrate (Ro 13-8996) is the nitrate salt form of oxiconazole, a broad spectrum imidazole derivative with antifungal activity. Although the exact mechanism of action has yet to be fully elucidated, oxiconazole... | |||
T7530 | PD146176 | NSC168807 | Ferroptosis , Lipoxygenase , Autophagy |
PD146176 (NSC-168807) is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM. PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology... | |||
T1646 | Famciclovir | BRL 42810 | DNA/RNA Synthesis , HSV |
Famciclovir (BRL 42810) is a Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor. The mechanism of action of famciclovir is as a DNA Polymerase Inhibitor, and DNA Polymerase Inhibitor. | |||
T0839 | Ketoprofen | RP-19583 | Apoptosis , COX , MRP |
Ketoprofen (RP-19583) is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic effects. Ketoprofen inhibits the activity of the enzymes cyclo-oxygenas... | |||
T1824 | TGR5 Receptor Agonist | GPCR19 | |
TGR5 is a potent TGR5(GPCR19) agonist. | |||
T6832 | Fatostatin hydrobromide | Fatostatin HBr,Fatostatin A,Fatostatin A HBr,Fatostatin | NPC1L1 , Fatty Acid Synthase |
Fatostatin hydrobromide (Fatostatin A HBr) ia an inhibitor of sterol regulatory element binding protein (SREBP). It impairs the activation of SREBP-1 and SREBP-2. | |||
T2275 | YK-4-279 | Apoptosis , DNA/RNA Synthesis | |
YK 4-279, an inhibitor of RNA Helicase A (RHA), binds to the oncogenic transciption factor EWS-FLI1. | |||
T8825 | Capmatinib 2HCl.H2O | INCB28060 2HCl.H2O,INC-280 2HCl.H2O,NVP-INC280 2HCl.H2O | c-Met/HGFR |
Capmatinib 2HCl.H2O (NVP-INC280 2HCl.H2O) is an orally bioavailable inhibitor of the proto-oncogene c-Met (HGFR)with potential antineoplastic activity. | |||
T7804 | Garenoxacin mesylate hydrate | Garenoxacin mesylate [USAN],BMS284756 (Mesylate hydrate) | Antibacterial |
Garenoxacin mesylate hydrate (Garenoxacin mesylate [USAN]) with potent antimicrobial activity, against common respiratory pathogens, including resistant strains. | |||
T4383 | GSK-J4 Hydrochloride | GSK J4 HCl,GSK J4 HCl (1373423-53-0 free base) | Histone Demethylase |
GSK-J4 Hydrochloride (GSK J4 HCl) is a cell permeable, potent and selective histone demethylase(JMJD3 )inhibitor. is an ethyl ester derivative of the GSK-J1 with an IC50 value greater than 50 μM in vitro. | |||
T8416 | Capmatinib xHCl | INCB28060,Capmatinib hydrochloride(free base),INC280 | c-Met/HGFR |
Capmatinib xHCl (INCB28060) is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor, potently blocking in vitro kinase activity (IC50 = 0.13 nM) as well as constitutive or HGF-stimulated activit... | |||
T1963 | Capmatinib | NVP-INC280,INC-280,INCB28060 | Apoptosis , c-Met/HGFR |
Capmatinib (INCB28060) is an orally bioavailable inhibitor of the proto-oncogene c-Met (HGFR)with potential antineoplastic activity. | |||
TQ0157 | EIPA | L593754,MH 12-43 | Sodium Channel , TRP/TRPV Channel |
EIPA (L593754) (L593754, MH 12-43) is a TRPP3 channel inhibitor (IC50: 10.5 μM). It also inhibits Na+/H+-exchanger (NHE) and macropinocytosis. | |||
T5045 | GSK4112 | 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate,SR6452 | Autophagy |
GSK4112 (SR6452) is a Rev-erbα agonist with EC50 of 0.4 μM, also is a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα. | |||
T4260 | Capmatinib 2HCl | INC-280 2HCl,INCB28060 2HCl | c-Met/HGFR |
Capmatinib 2HCl (INC-280 2HCl) is a novel, ATP-competitive inhibitor of c-MET kinase with an IC50 with 0.13 nM.Capmatinib 2HCl exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10, 000-... | |||
T7179 | Garenoxacin | BMS284756 | Antibacterial |
Garenoxacin (BMS284756) is a novel oral des-fluoro(6) quinolone for the treatment of Gram-positive and Gram-negative bacterial infections. | |||
T15214 | Emicerfont | GW876008 | Others |
Emicerfont is an antagonist of the corticotropin-releasing factor type 1 receptor (IC50: 66 nM). | |||
T76135 | Hemicellulase | ||
Hemicellulase, a member of the glycoside hydrolase enzyme family, plays a pivotal role in the degradation of plant biomass and carbon flow in nature. It facilitates the breakdown of glucose and polymer bonds within plant... | |||
T10313 | AMXT-1501 tetrahydrochloride | Others | |
AMXT-1501 tetrahydrochloride is an inhibitor of polyamine transport. It blocks tumor growth in immunocompetent mice but not in athymic nude mice lacking T cells. | |||
T21870 | C-021 | 4-Quinazolinamine, 2-[1,4'-bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy- | CCR |
C 021 dihydrochloride is a potent CCR4 antagonist. C-021 (4-Quinazolinamine, 2-[1,4'-bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-) dihydrochloride potently inhibits functional chemotaxis in humans and mice with IC50s ... | |||
T35033 | Vamicamide | FK 176,FK-176,FK176 | AChE |
Vamicamide (FK 176) is a novel anticholinergic compound. Vamicamide increases spontaneous locomotor activity in mice at 32 mg/kg (p.o.) or higher and inhibits cataleptic convulsions in mice at 100 mg/kg. | |||
T0807 | Tribromoethyl alcohol | 2,2,2-Tribromoethanol,Avertin,Basibrol,Tribromoethanol,TBE | Others |
Tribromoethyl alcohol (Avertin) is an organic compound used to anesthetize mice. | |||
T35033L | (S)-Vamicamide | (S)-Vamicamide (Iso-132373-81-0) | AChE |
(S)-Vamicamide is a novel anticholinergic compound.Vamicamide increases spontaneous locomotor activity in mice at 32 mg/kg or higher (p.o.) and inhibits tonic convulsions in mice at 100 mg/kg.CAS 번호13483-86-1 | |||
T68166L | Traxanox TFA | Traxanox TFA(58712-69-9 Free base) | Others |
Traxanox TFA is an orally available diuretic. Traxanox TFA enhances phagocytosis of yeast granules by mouse peritoneal macrophages or rat peritoneal polymorphonuclear leukocytes in vitro. Traxanox TFA restores inhibition... |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T5661 | Methyl isoeugenol | Others | |
methyl isoeugenol (MIE) is a natural food flavour that constitutes 93.7% of an essential oil from Pimenta pseudocaryophyllus leaf. The leaf extracts of this species are used as a calming agent. As a ubiquitous food addit... | |||
T2869 | Emodin | Frangula emodin | SARS-CoV , Casein Kinase , Autophagy |
Emodin (Frangula emodin) is a naturally occurring anthraquinone present in the roots and barks of numerous plants; exerts antiproliferative effects in Y cells that are regulated by different signaling pathways. | |||
T0983 | Penicillamine | d-penicillamin,Dimethyl Cysteine,Artamine,D-(-)-Penicillamine | Antibiotic |
Penicillamine (Artamine), possessing antineoplastic properties, induces apoptosis by a p53-mediated mechanism and inhibits angiogenesis by chelating with copper, a cofactor for angiogenesis. Artamine is a beta dimethyl a... | |||
TN1818 | Kaempferol 3-O-β-D-glucuronide | Kaempferol-3-O-glucuronide,Kaempferol-3-beta-O-glucuronide,Kaempferol-3-glucuronide | IL Receptor |
Kaempferol 3-O-β-D-glucuronide (Kaempferol-3-beta-O-glucuronide)e has antioxidant activity. Flavonoid glucuronides can be deconjugated by microsomal α²-glucuronidase from various human cells. | |||
T4984 | Cefozopran hydrochloride | SCE-2787 hydrochloride | Antifungal |
Cefozopran hydrochloride (SCE-2787 hydrochloride) is a fourth-generation cephalosporin. is a cell wall biosynthesis inhibitor with a broad spectrum of activity against Gram-positive and Gram-negative bacteria. | |||
T73853 | Amicetin | ||
Amicetin, a potent antibiotic, is effective against gram-positive bacteria by inhibiting protein synthesis [1] [2] [3]. | |||
T4396 | Officinalisinin I | Others | |
Officinalisinin I can effectively reduce the blood glucose and protect nerve injuryin diabetic mice. | |||
T13903 | Stearoylethanolamide | N-(2-Hydroxyethyl)octadecanamide | Apoptosis |
Stearoylethanolamide(N-(2-Hydroxyethyl)octadecanamide) is a cannabinoid compound present in the brains of humans, rats, and mice with pro-apoptotic activity. | |||
T2S0967 | Sennoside C | Others | |
Sennoside C is an anthraquinone glycoside extracted from leaves and pods of Senna and has an auxiliary effect on the laxative effect of mice. | |||
TN1757 | Hypophyllanthin | Potassium Channel , Calcium Channel , P-gp | |
Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice. | |||
T4588 | Glycochenodeoxycholic Acid | Glycine chenodeoxycholate,Chenodeoxycholylglycine,GCDCA,Glycochenodeoxycholate,Lithocholylglycine | Apoptosis , Endogenous Metabolite |
Glycochenodeoxycholic Acid (Lithocholylglycine) is a glycine conjugate of lithocholic acid, a bile acid. It is increased in livers of mice that are fed diets supplemented with ursadeoxycholic acid. Glycolithocholic acid ... | |||
T6985 | Benzo[a]pyrene | 3,4-Benzopyrene | Others |
Benzo[a]pyrene (3,4-Benzopyrene) shows lung carcinogenicity in mice in a dose-dependent manner. | |||
T3698 | Alpha-Asarone | α-Asarone,trans-Asarone | P450 , GABA Receptor , HMG-CoA Reductase |
alpha-Asarone (trans-Asarone) is a psychoactive compound with antidepressant-like activity in mice. | |||
T5S0669 | Bergamottin | 5-Geranoxypsoralen,Bergamotine,Bergaptin | P450 |
1. Bergamottin (5-Geranoxypsoralen) can significantly reduce blood glucose and increase glucose tolerance and insulin sensitivity in KK-A<sup>y</sup>diabetic mice. | |||
T6S1885 | Benzoylmesaconine | Mesaconine 14-benzoate | Others |
Benzoylmesaconine (Mesaconine 14-benzoate) is the most abundant component of Wutou decoction, which is widely used in China because of its therapeutic effect on rheumatoid arthritis. Benzoylmesconine has analgesic activi... | |||
T20225 | Dicentrine, (-)- | L-Dicentrine,NSC 251699,NSC251699,NSC-251699 | Others |
Dicentrine, (-)- (NSC-251699) is an aporphinic alkaloid found in several plant species, which showed significant antinociceptive activity in an acute model of visceral pain in mice. | |||
TN1111 | Arnidiol | Immunology/Inflammation related | |
Arnidiol has anti-inflammatory activity, it possesses marked inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice. | |||
T5S0229 | Isosakuranetin | 4'-Methylnaringenin | Others |
1. Isosakuranetin (4'-Methylnaringenin) has cytotoxic and fungicide properties. 2. Isosakuranetin produces significant decrease in blood pressure. 3. Isosakuranetin significantly reduces the sensitivity of mice to noxiou... | |||
TN2151 | Rhamnocitrin | Others | |
Rhamnocitrin can enhance the immune function, improve the formation of spleen cells of mice serum hemolysin of chicken red blood cell immune. | |||
TN2088 | Platycodin D2 | IL Receptor , HBV | |
Platycodin D2 , a less hemolytic saponin, can improve specific cellular and humoral responses to hepatitis B surface antigen in mice, it could be safely used as adjuvant eliciting Th1 and Th2 immune responses. Polygalaci... | |||
TQ0213 | Bruceantin | (-)-Bruceantin,NCI165563,NSC165563 | Others |
T5735 | Methyl deacetylasperulosidate | Deacetyl asperulosidic acid methyl ester,6α-Hydroxygeniposide | Others |
Methyl deacetylasperulosidate (6α-Hydroxygeniposide) is a natual product isolated from the herbs of Hedyotis diffusa Willd,it can lower the blood glucose level in normal mice. | |||
TN2230 | Soyasaponin Ba | Others | |
Soyasaponin Ba may represent viable candidates for effective vaccine adjuvants due to their higher and lower or non-haemolytic effects.Soyasaponins Ab and Bb prevent scopolamine-induced memory impairment in mice without ... | |||
T19924 | Rhododendrol | Betuligenol,Frambinol | Others |
Rhododendrol (Frambinol) is a melanin synthesis and acts by preventing high-fat diet-induced elevation in body weight and increasing lipolysis in white adipocytes in male mice. Rhododendrol can be used as the lightening/... | |||
T10822 | Cirsimarin | Cirsitakaoside | Adenosine Receptor |
Cirsimarin (Cirsitakaoside) is a flavonoid isolated from Microtea debilis. It shows a potent antilipogenic effect and decreases adipose tissue deposition in mice. Cirsimarin has antagonist activity on the adenosine A1 re... | |||
TN1256 | 3-O-Acetyl-16α-hydroxytrametenolic acid | 3-O-Acetyl-16 alpha-hydroxytrametenolic acid | Immunology/Inflammation related |
3-O-Acetyl-16α-hydroxytrametenolic acid has inhibitory activities against AAPH-induced hemolysis of red blood cells, it shows a strong inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate-induced inflammation... | |||
T7036 | 2,4'-Dihydroxybenzophenone | Antioxidant | |
2,4'-Dihydroxybenzophenone can effectively protect C57BL/6J mice from APAP-induced hepatotoxicity. Its mechanisms might be associated with its Antioxidant activity. | |||
T6S0721 | Orientin | Lutexin,Luteolin-8-glucoside | Others |
1. Orientin (Luteolin-8-glucoside) may be regarded as a candidate therapeutic agent for treatment of vascular inflammatory diseases via inhibition of the HMGB1 signaling pathway. 2. Orientin protects vascular barrier int... | |||
T5773 | Moslosooflavone | 5-hydroxy-7,8-dimethoxyflavone | NF-κB , Reactive Oxygen Species |
Moslosooflavone (5-hydroxy-7,8-dimethoxyflavone) has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice. 5-hydroxy-7,8-dimethoxyflavone significantly inhibits the transcriptional activi... | |||
T0632 | 3,4,5-Trimethoxybenzoic acid | Gallic acid trimethyl ether,Eudesmic acid,Trimethylgallic Acid,Benzoic acid,Tri-O-methylgallic acid | Antioxidant |
3,4,5-Trimethoxybenzoic acid (Gallic acid trimethyl ether) are potent antioxidants and inhibitor of cytokine production. It can ameliorate chronic stress-induced various behavioral and biochemical alterations in mice. It... | |||
T5S2083 | Puerarin 6''-O-Xyloside | Apoptosis , Caspase | |
Puerarin 6''-O-xyloside possesses significant anti-osteoporotic activity on ovariectomy mice, it has significant antitumour activities, the mechanisms are related to increased levels of caspase-3, caspase-7, caspase-9 an... | |||
T2777 | Ginsenoside Rg1 | Sanchinoside C1,Panaxoside Rg1,Sanchinoside Rg1,Panaxoside A,Ginsenoside A2 | Apoptosis , Beta Amyloid , NF-κB |
Ginsenoside Rg1 (Panaxoside Rg1) is a class of steroid glycosides, and triterpene saponins found exclusively in the plant genus Panax (ginseng). It improves spatial learning and increase hippocampal synaptophysin level i... | |||
T5S0285 | Cistanoside A | Others | |
1. Cistanoside A possesses protective activities on CCl4 induced hepatotoxicity in mice, which is involved with increasing free radicals clearing activities, alleviating lipid-overoxidation damage, and improving respirat... | |||
T3887 | Rosarin | Others | |
Rosarin has anti-inflammatory and neuroprotective effects. Rosarin supresses the expression of the proinflammatory factors iNOS, IL-1 β, and TNF- α in the kidney and prefrontal cortex of brain in mice . | |||
TN2089 | Platycodin D3 | HCV Protease , NF-κB | |
Platycodin D3 is a NF-κB inhibitor, it could as expectorants in diverse inflammatory pulmonary diseases, it can regulate the production and secretion of airway mucin; it can significantly enhance mitogen- and OVA-induced... | |||
T3662 | Eleutheroside E | NF-κB | |
Eleutheroside E has anti-inflammatory effects by inhibiting NF-κB activities. Eleutheroside E significantly decreases the inflammatory cell infiltration, pannus formation, cartilage damage, bone erosion of CIA mice, the ... | |||
T5715 | (E)-Flavokawain A | FLAVOKAVAIN A(P) | Apoptosis , P450 |
(E)-Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice. | |||
T3005 | 4-Hydroxychalcone | P-Cinnamoylphenol | Others , NF-κB |
4-Hydroxychalcone (P-Cinnamoylphenol) attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice. | |||
T4S2164 | Narirutin | Naringenin-7-O-rutinoside,Isonaringin | Others , Antibacterial |
1. Narirutin (Naringenin-7-O-rutinoside) has antiproliferative property. 2. Narirutin has anti-oxidant property. 3. Narirutin has anti-allergic and anti-inflammatory properties , can reduce airway inflammation in ovalbum... | |||
T3999 | D(+)-Galactosamine hydrochloride | D-Galactosamine HCl | Others |
D(+)-Galactosamine hydrochloride (D-Galactosamine HCl) hepatotoxicity is associated with endotoxin sensitivity and mediated by lymphoreticular cells in mice. | |||
TN1236 | 3',4',7-Trihydroxyisoflavone | MAPK , JNK | |
3',4',7-Trihydroxyisoflavone is a soy isoflavone soy glycoside derivative and Cot (Tpl2/MAP3K8) and MKK4 inhibitor with anticancer, antiangiogenic and free radical scavenging properties.3',4',7-Trihydroxyisoflavone enhan... | |||
T4A2462 | Telocinobufagin | Telobufotoxin,Telocinobufogenin | Others |
1. Telocinobufagin (Telobufotoxin) is the major endogenous digitalis-like factor. 2. Telocinobufagin significantly decreases the bacterial burdens in the spleen and prolongs the survival time of FIST-immunized mice chall... | |||
TN1420 | Bacopaside I | Others | |
Bacopaside I is a saponin isolated from Bacopa monniera. Bacopaside I is a modulator of Aquaporin-1 channel, has neuroprotective functions, it has anti-Alzheimer's disease, it ameliorates cognitive impairment in APP/PS1 ... | |||
T5702 | Tenuifoliside B | Dehydrogenase | |
Tenuifoliside B is a natural product from the roots of Polygala tenuifolia.And is a target lactate dehydrogenase inhibitor. Tenuifoliside B has cognitive improving and cerebral protective effects. it can inhibit potassi... | |||
T5217 | 2-(2-Phenylacetamido)acetic acid | Phenaceturic acid,Phenyl-ac-Gly-OH,Phenylacetyl glycine | Others , Endogenous Metabolite |
2-(2-Phenylacetamido)acetic acid (Phenyl-ac-Gly-OH) is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids. The presence of phenylacetylglycine in urine has been confirmed for dogs, rats, and mic... | |||
TN1936 | Mogroside III-E | IL Receptor , TNF , TLR | |
Mogroside III-E is a cucurbitane-type compound isolated from Siraitia grosvenorii, has anti-inflammatory activity, it attenuates LPS-induced acute lung injury in mice partly through regulation of the TLR4/MAPK/NF-κB axis... | |||
TN7235 | 4-methoxylonchocarpin | TNF , NF-κB | |
4-methoxylonchocarpin was isolated from the roots of Abrus precatorius as a potent anti-inflammatory compound. 4-methoxylonchocarpin inhibited NF-κB-activated TNF expression by inhibiting the binding of LPS to TLR4 in ma... | |||
T3S1513 | (20R)-Protopanaxadiol | Protopanaxadiol,20R-Protopanaxadiol,(20R)-Protopanaxdiol | Others , Antibacterial |
1. (20R)-Protopanaxadiol ((20R)-Protopanaxdiol) has the effect of anti-tumor through increasing the activity of body immunity, inhibiting tumor interstitial microvascular density and its proliferation activity, improving... | |||
T14305 | Apicidin | OSI 2040 | Apoptosis , HDAC , Autophagy |
Apicidin (OSI 2040) is a histone deacetylase (HDAC) inhibitor with antiparasitic activity and antiproliferative activity.Apicidin attenuates memory deficits, inhibits cell growth and proliferation, and induces apoptosis ... | |||
T5S0384 | Rhapontin | Ponticin,Rhaponiticin,Rhaponticin,Rhapontigenin glucoside | Apoptosis , Others |
1. Rhapontin (Ponticin) can alleviate liver steatosis and improve blood glucose and lipid profiles in KK/Ay diabetic mice, indicates that rhaponticin has a noticeable antidiabetic effect and could be potentially used as ... | |||
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カタログ番号 | 製品名 | Species | Expression System |
---|---|---|---|
TMPH-03625 | Alpha-mammal toxin Ts2 Protein, Tityus serrulatus, Recombinant (His & Myc) | Tityus serrulatus | Baculovirus Insect Cells |
Alpha-mammal toxin Ts2 Protein, Tityus serrulatus, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 10.9 kDa and the accession number is P684... | |||
TMPH-03626 | Beta-mammal/insect toxin Ts1 Protein, Tityus serrulatus, Recombinant (His & Myc) | Tityus serrulatus | Baculovirus Insect Cells |
Beta-mammal/insect toxin Ts1 Protein, Tityus serrulatus, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 10.8 kDa and the accession number i... | |||
TMPH-03627 | Beta-mammal/insect toxin Ts1 Protein, Tityus serrulatus, Recombinant (E. coli, His & Myc) | Tityus serrulatus | E. coli |
Beta-mammal/insect toxin Ts1 Protein, Tityus serrulatus, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 14.3 kDa and the accessio... | |||
TMPH-01433 | Hemicentin-1 Protein, Human, Recombinant (His) | Human | E. coli |
Hemicentin-1 Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPK-00735 | CXCL13/BCA-1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Recent studies have implicated chemokines in microglial activation and pathogenesis of neuropathic pain. C-X-C motif chemokine 13 (CXCL13) is a B lymphocyte chemoattractant that activates CXCR5. Using the spinal nerve li... | |||
TMPJ-00261 | TGF beta 2 Protein, Mouse/Rat, Recombinant | Mouse,Rat | HEK293 Cells |
Transforming growth factor beta 2 (TGF-β2) is a member of TGF-beta superfamily that shares a characteristic cysteine knot structure. Mice with TGF-β2 gene deletion show defects in development of cardiac, lung, craniofaci... | |||
TMPY-03425 | Tau Protein, Human, Recombinant (His) | Human | E. coli |
MAPT (microtubule-associated protein tau) can produce tau proteins. Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are... | |||
TMPJ-01172 | IL-17 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. Mature mouse IL-17A shares 61% and 89% amino acid seque... | |||
TMPY-02028 | RON/CD136 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
The tyrosine kinase receptor, macrophage-stimulating 1 receptor (MST1R), a c-met-related tyrosine kinase, also known as the Ron receptor or CD136, controls cell survival and motility programs related to invasive growth. ... | |||
TMPK-01065 | SEZ6 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform o... | |||
TMPK-00541 | SEZ6 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform o... | |||
TMPK-00875 | CD96 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells |
The receptors CD96 and TIGIT are expressed on the surface of T and natural killer (NK) cells, and recent studies suggest both play important inhibitory roles in immune function. CD96 has been shown to modulate immune cel... | |||
TMPK-00996 | SEZ6 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells |
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform o... | |||
TMPK-00998 | SEZ6 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform o... | |||
TMPK-00997 | SEZ6 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform o... | |||
TMPK-01171 | FOLR4/Juno Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Izumo1 is the only essential sperm-egg fusion protein currently known on mammalian sperm, and its egg receptor (Juno; formerly Folr4) was recently discovered. Male knockout mice for Izumo1 and female knockout mice for Ju... | |||
TMPK-00585 | FOLR4/Juno Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Izumo1 is the only essential sperm-egg fusion protein currently known on mammalian sperm, and its egg receptor (Juno; formerly Folr4) was recently discovered. Male knockout mice for Izumo1 and female knockout mice for Ju... | |||
TMPH-00351 | Fel d 4 Protein, Feline, Recombinant (His & SUMO) | Feline | E. coli |
May be a pheromone carrier. Acts as a kairomone, detected by the prey vomeronasal organ and inducing fear reactions in mice. Fel d 4 Protein, Feline, Recombinant (His & SUMO) is expressed in E. coli expression system wit... | |||
TMPY-04373 | CAMKII alpha/CAMK2A Protein, Human, Recombinant (GST) | Human | Baculovirus Insect Cells |
Ca2+/calmodulin-dependent protein kinase2A (CAMK2A) belongs to the serine/threonine protein kinase family and, together with other 28 different isoforms, belongs to the Ca2+/ calmodulin-dependent protein kinase subfamily... | |||
TMPY-02624 | IL-9R Protein, Rat, Recombinant (His) | Rat | HEK293 Cells |
IL9R (Interleukin 9 Receptor) is a Protein Coding gene. The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 (IL9). IL9 is involved in mast cell matur... | |||
TMPJ-00052 | Leptin Protein, Mouse, Recombinant | Mouse | E. coli |
Leptin is a hormone secreted from white adipocytes and plays important role in the regulation of food intake and energy balance. Leptin functions via signaling pathways involving OB-R in hypothalamus. Animal models have ... | |||
TMPJ-01083 | Serpin E2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Serpin E2 is a member of the Serpin superfamily. It is differentially expressed during neuronal differentiation and is able to transform human embryonic kidney cells into neuronlike cells. Its over-expression in mice lea... | |||
TMPK-01202 | CD93/C1qR1 Protein, Human, Recombinant (His&Avi), Biotinylated | Human | HEK293 Cells |
CD93 has been shown critical roles in inflammatory and immune diseases. CD93 silencing increased IL-6 and TSLP, but not IL-33 levels in culture supernatants. HDM-induced asthma mice showed significant airway hyperrespons... | |||
TMPY-02686 | PON3 Protein, Human, Recombinant (S50N, His) | Human | Baculovirus Insect Cells |
PON3 was enriched in the mitochondria-associated membrane fraction of hepatocytes. PON3 deficiency resulted in impaired mitochondrial respiration, increased mitochondrial superoxide levels, and increased hepatic expressi... | |||
TMPK-00237 | 2B4/CD244 Protein, Human, Recombinant (aa 22-221, His & Avi), Biotinylated | Human | HEK293 Cells |
2B4 (CD244) is expressed by memory-phenotype CD8() T cells and all natural killer (NK) cells. The ligand for 2B4, CD48, is expressed on hematopoietic cells. 2B4 is conserved in humans and mice, and a number of reports ha... | |||
TMPK-01387 | EPhA3 Protein, Canine, Recombinant (His) | Canine | HEK293 Cells |
Erythropoietin‑producing hepatocellular carcinoma cell surface type‑A receptor 3 (EPHA3) has been found to promote the proliferation and survival of prostate cancer (PCa) cell lines and prostate tumor development in nude... | |||
TMPH-02404 | LqhaIT Protein, Leiurus hebraeus, Recombinant (His & SUMO) | Yellow scorpion | E. coli |
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. The dissociation is voltage-dependent. This toxin... | |||
TMPK-00775 | PRNP/Prion Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
Prion protein gene (PRNP) variants determine the susceptibility of humans, sheep and mice to prion diseases, whereas polymorphisms in the open reading frame (ORF) of bovine PRNP seem to be unrelated to the incidence of b... | |||
TMPK-00734 | CXCL13/BCA-1 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
Recent studies have implicated chemokines in microglial activation and pathogenesis of neuropathic pain. C-X-C motif chemokine 13 (CXCL13) is a B lymphocyte chemoattractant that activates CXCR5. Using the spinal nerve li... | |||
TMPJ-00299 | LIMPII/SR-B2 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
Lysosome membrane protein II (LIMPII),also known as SCARB2, is a type III multi-pass membrane glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes on all tissues and cell types so far e... | |||
TMPJ-00298 | CD36 Protein, Human, Recombinant (aa 27-432, His) | Human | HEK293 Cells |
Scavenger Receptor Class B Member 2 (SCARB2) is a type III multi-pass membrane glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes on all tissues and cell types so far examined. Earlie... | |||
TMPK-00017 | CXCL13/BCA-1 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Recent studies have implicated chemokines in microglial activation and pathogenesis of neuropathic pain. C-X-C motif chemokine 13 (CXCL13) is a B lymphocyte chemoattractant that activates CXCR5. Using the spinal nerve li... | |||
TMPK-01165 | MCEMP1 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
A cecal ligation and puncture-induced sepsis mouse model was established to determine the expression of mast cell expression membrane protein 1 (MCEMP1). MCEMP1 in T lymphocytes isolated from sepsis mice were up- or down... | |||
TMPK-00018 | CXCL13/BCA-1 Protein, Human, Recombinant (His & Sumo) | Human | E. coli |
Recent studies have implicated chemokines in microglial activation and pathogenesis of neuropathic pain. C-X-C motif chemokine 13 (CXCL13) is a B lymphocyte chemoattractant that activates CXCR5. Using the spinal nerve li... | |||
TMPK-00888 | TGF alpha Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
Transforming growth factor-alpha (TGFA) has been proposed as a candidate gene in the etiology of nonsyndromic cleft lip with or without cleft palate (NS-CL/P) and of nonsyndromic cleft palate only (NS-CPO). Biologic supp... | |||
TMPK-00113 | Pentraxin 2/SAP Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
Pentraxin-2 (PTX-2), also known as serum amyloid P component (SAP/APCS), is a constitutive, antiinflammatory, innate immune plasma protein whose circulating level is decreased in chronic human fibrotic recombinant human ... | |||
TMPK-00651 | SLAMF6 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
SLAMF6 (signaling lymphocyte activation molecule 6) (Ly108 in mice, NTB-A or SF2000 in humans) is a homophilic receptor belonging to the superfamily immunoglobulin (Ig) domain-containing molecules. It is known to be wide... | |||
TMPH-03035 | M-myrmeciitoxin-Mp2b Protein, Myrmecia pilosula, Recombinant (GST & His) | Myrmecia pilosula | Baculovirus Insect Cells |
Heterodimer protein that may serve both defensive (pain-inducing) and predatory (insecticidal) roles. Has membrane-disrupting activity and shows induction of non-specific calcium influx into cells,. Shows broad-spectrum ... | |||
TMPK-00757 | TGF alpha Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Transforming growth factor-alpha (TGFA) has been proposed as a candidate gene in the etiology of nonsyndromic cleft lip with or without cleft palate (NS-CL/P) and of nonsyndromic cleft palate only (NS-CPO). Biologic supp... | |||
TMPK-00491 | IL-18BP Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
Cytokines were the first modern immunotherapies to produce durable responses in patients with advanced cancer,components of the interleukin-18 (IL-18) pathway are upregulated on tumour-infiltrating lymphocytes, suggestin... | |||
TMPY-02651 | P63 Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells |
Tumor protein p63 is a protein also known as transformation-related protein 63, TP63, and p63. Tumor protein p63 / p63 is a member of the p53 family of transcription factors whose members P53, p63, and p73 have similar f... | |||
TMPK-00056 | IL-10 Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells |
Interleukin 10 (IL10) is a key anti-inflammatory cytokine that can inhibit proinflammatory responses of both innate and adaptive immune cells. An association between IL10 and intestinal mucosal homeostasis became clear w... | |||
TMPK-01174 | SLAMF6 Protein, Mouse, Recombinant (aa 31-239, His) | Mouse | HEK293 Cells |
SLAMF6 (signaling lymphocyte activation molecule 6) (Ly108 in mice, NTB-A or SF2000 in humans) is a homophilic receptor belonging to the superfamily immunoglobulin (Ig) domain-containing molecules. It is known to be wide... | |||
TMPJ-00067 | BAFFR/TNFRSF13C Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Tumor necrosis factor receptor superfamily, member 13C (TNFRSF13C) also known as B-cell-activating factor receptor (BAFFR) and CD268 antigen, is a member of the tumor necrosis factor receptor superfamily. BAFF promotes t... | |||
TMPK-00057 | IL-10 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells |
Interleukin 10 (IL10) is a key anti-inflammatory cytokine that can inhibit proinflammatory responses of both innate and adaptive immune cells. An association between IL10 and intestinal mucosal homeostasis became clear w... | |||
TMPK-00222 | SLAMF6 Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells |
SLAMF6 (signaling lymphocyte activation molecule 6) (Ly108 in mice, NTB-A or SF2000 in humans) is a homophilic receptor belonging to the superfamily immunoglobulin (Ig) domain-containing molecules. It is known to be wide... | |||
TMPK-00765 | Pentraxin 2/SAP Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Pentraxin-2 (PTX-2), also known as serum amyloid P component (SAP/APCS), is a constitutive, antiinflammatory, innate immune plasma protein whose circulating level is decreased in chronic human fibrotic recombinant human ... | |||
TMPK-01168 | LOX-1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
LOX-1 is a transmembrane glycoprotein that binds to and internalizes ox-LDL.LOX-1 gene deletion in mice and anti-LOX-1 therapy has been shown to decrease inflammation, oxidative stress and atherosclerosis. LOX-1 deletion... | |||
TMPK-00827 | CD43 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
CD43 is a large transmembrane protein involved in T cell activation. Previous studies of CD43-/- mice in viral models have demonstrated a role for CD43 in Th1/Th2 skewing, activation of Foxp3 Treg, and T cell apoptosis. ... | |||
TMPK-00082 | IL-18BP Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells |
Cytokines were the first modern immunotherapies to produce durable responses in patients with advanced cancer,components of the interleukin-18 (IL-18) pathway are upregulated on tumour-infiltrating lymphocytes, suggestin... | |||
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カタログ番号 | 製品名 | ||
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L9700 | Endoplasmic Reticulum Stress Compound Library | 193 compounds | |
A unique collection of 193 endoplasmic reticulum stress (ER stress) related compounds used for high throughput screening (HTS) and high content screening (HCS); |