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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
TP1422 | Interleukin (IL)-6 Receptor | Others | |
Interleukin (IL)-6 Receptor is a peptide. | |||
T8477 | IQ-3 | JNK | |
IQ3 is a selective inhibitor of JNK3(JNK3, JNK1 and JNK2 with Kd of 66 nM, 240 nM and 290 nM, respectively). IQ 3 inhibits NF-κB/AP1 transcriptional activity in THP1-Blue cells with IC50 of 1.4 μM, also inhibits TNF-α an... | |||
T9926 | Omalizumab | Others | |
Omalizumab is a recombinant humanized monoclonal antibody against human immunoglobulin E IgE) | |||
T5110 | IRAK inhibitor 6 | IRAK | |
IRAK inhibitor 6 is an inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK-4, IC50: 160 nM). | |||
T8692 | (Rac)-Benpyrine | TNF | |
(Rac)-Benpyrine is a potent and orally active inhibitor of TNF-α. | |||
T6761 | Ossirene | AS101 | IL Receptor , Caspase , Interleukin |
Ossirene (AS101), a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta converting enzyme. | |||
T40423 | L48H37 | Others | |
L48H37 is a chemically stable analog of Curcumin. It exhibits potent inhibitory properties against myeloid differentiation protein 2 (MD2), acting as a specific inhibitor. Its mechanism involves inhibiting the interactio... | |||
T27695 | JTE-607 | JTE-607 dihydrochloride,JTE-607 HCl | Cysteine Protease |
JTE-607 is a cytokine production inhibitor. JTE-607 induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells. | |||
T6927 | Pamapimod | R1503,Ro4402257 | p38 MAPK , Autophagy |
Pamapimod (R1503) (R-1503, Ro4402257) is a novel, selective inhibitor of p38 mitogen-activated protein kinase. It inhibits p38α and p38β enzymatic activity with IC50 values of 0.014±0.002 and 0.48± 0.04 microM, respectiv... | |||
T8705 | BOT-64 | IκB/IKK | |
BOT-64 is an IKK-2 inhibitor which targets the Ser177 and/or Ser181 residues in the kinase's activation loop domain.BOT-64 is a cell-permeable benzoxathiole compound | |||
T14943 | CGP60474 | VEGFR , CDK , PKC | |
CGP60474 is an inhibitor of VEGFR-2 (IC50 = 84 nM) and an inhibitor of ATP-competitive PKC. CGP60474 is also a highly potent anti-endotoxemic agent and inhibits cyclin-dependent kinase (CDK) potently. | |||
T11793 | KY-05009 | Wnt/beta-catenin | |
KY-05009 is a chemical compound that effectively suppresses TGF-β1-induced epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma cells, reduces TNIK protein expression and the transcriptional activity o... | |||
T2036 | 6-OAU | GTPL5846 | GPR |
6-OAU (GTPL5846)(GTPL5846; 6-n-octylaminouracil) is a surrogate agonist of GPR84; activates human GPR84 in the presence of Gqi5 chimera in HEK293 cells with an EC50 of 105 nM in the PI assay. | |||
T4602 | Hydrocortisone hemisuccinate | Hydrocortisone 21-he,hydrocortisone 21-hemisuccinate*free acid,Hydrocortisone 21-hemisuccinate | Glucocorticoid Receptor , Others , Interleukin |
Hydrocortisone hemisuccinate (hydrocortisone 21-hemisuccinate*free acid) is a corticosteroid used as an analytical and chromatography reagent. | |||
T6950 | PNU-120596 | NSC 216666 | AChR |
PNU-120596 (NSC-216666) is a positive allosteric modulator of α7 nAChR with EC50 of 216 nM. | |||
T16501 | PF-3644022 | p38 MAPK , Serine Protease , MAPK | |
PF-3644022 is an effective, selective, and ATP-competitive MAPKAPK2 (MK2) inhibitor (IC50: 5.2 nM and a Ki of 3 nM). PF-3644022 potently inhibits TNFα production and has an anti-inflammatory effect. PF-3644022 also inhib... | |||
TQ0181 | Resatorvid | CLI-095,TAK-242 | TNF , TLR , Autophagy , Interleukin |
Resatorvid (TAK-242) is a selective inhibitor of Toll-like receptor 4 (TLR4). Resatorvid binds directly to Cys747 and prevents TLR4 from binding to TIRAP, thereby blocking downstream signaling. Resatorvid has antitumor a... | |||
T2544 | Bazedoxifene acetate | WAY-TES 424,TSE 424,WAY-140424 | Estrogen Receptor/ERR , Estrogen/progestogen Receptor |
Bazedoxifene acetate (WAY-TES 424) is a novel selective estrogen receptor modulator (SERM). | |||
T6404 | Bazedoxifene hydrochloride | Bazedoxifene HCl,TSE-424 | Estrogen Receptor/ERR , Estrogen/progestogen Receptor |
Bazedoxifene hydrochloride (TSE-424) is a novel, non-steroidal, indole-based estrogen receptor modulator (SERM) binding to both ERα and ERβ with IC50 of 23 nM and 89 nM, respectively. | |||
T15769 | LMT-28 | IL Receptor | |
LMT-28 is an inhibitor of IL-6 and selectively inhibits IL-6-induced phosphorylation of gp130, STAT3, and JAK2. | |||
T76722 | Sarilumab | REGN-88,SAR-153191 | IL Receptor |
Sarilumab (SAR-153191)is a potent interleukin-6 IL-6 receptor antagonist and a human immunoglobulin G1 monoclonal antibody. Sarilumab inhibits IL-6-mediated signaling and reduces inflammation.Sarilumab is used for the pr... | |||
T4403 | AX-024 hydrochloride | AX-024 HCl | IL Receptor , TNF , COX , IFNAR , Interleukin |
AX-024 hydrochloride (AX-024 HCl) is an cytokine release inhibitor which can strongly inhibit the production of interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), interferon-γ (IFN-γ), IL-10 and IL-17A. | |||
T9581 | ARRY-797 | ARRY-371797 | IL Receptor , p38 MAPK |
ARRY-797 (ARRY-371797) is a potent and selective p38α inhibitor and inhibits LPS-Induced IL-6. | |||
T17107 | TMC353121 | IL Receptor , TNF , RSV | |
TMC353121 is a respiratory syncytial virus (RSV) fusion inhibitor with anti-RSV activity that inhibits the production of the inflammatory cytokines TNF-α, IL-6, and IL-1β, as well as chemokines, KC, IP-10, MCP, and MIP1-... | |||
T75174 | Anti-inflammatory agent 42 | IL Receptor , TNF | |
Anti-inflammatory agent 42 has anti-inflammatory activity and inhibits the expression of TNF-α and IL-6 in LPS-stimulated macrophages. | |||
T9911 | Tocilizumab | Interleukin | |
Tocilizumab (anti-IL-6R) is a humanized monoclonal antibody that binds to the interleukin-6 receptor | |||
T28958 | TG6-129 | TG6 129 | Prostaglandin Receptor |
TG6-129 is an antagonist of the EP2 receptor. TG6-129 suppresses PGE2-induced elevation of cAMP in cells expressing EP2 with an IC50 value of 1.6 µM. TG6-129 reduces the expression of COX-2, IL-1β, IL-6, IL-12, IL-23 and... | |||
T125076 | Hispidulin 7-glucuronide | IL Receptor | |
Hispidulin 7-glucuronide is a flavonoid that can be extracted from the leaves of mistletoe and has potential anti-inflammatory activity, inhibiting the release of IL-6. | |||
T27026 | CJ-13,610 | CJ 13610,CJ-13610 | Lipoxygenase |
CJ-13,610 is an orally active and nonredox-type inhibitor of 5-lipoxygenase (5-LOX). CJ-13,610 inhibits the biosynthesis of leukotriene B4 and regulates the expression of IL-6 mRNA in macrophages. | |||
T76978 | Siltuximab | CNTO-328 | IL Receptor |
Siltuximab(CNTO-328) is a monoclonal antibody with anti-tumor activity targeting IL-6 for the study of giant lymph node hyperplasia (MCD) and COVID-19. | |||
T60739L | Y13g dihydrochloride | Y13g 2HCl(T60739 Free base) | IL Receptor , AChE |
Y13g dihydrochloride is a potent inhibitor of interleukin 6 (IL-6) and acetylcholinesterase (AChE) (both targets of Alzheimer's disease (AD) progression are related). Y13g dihydrochloride reverses STZ-induced memory defi... | |||
T67924 | ABzOH | Others | |
ABzOH is a benzoic acid derivative, similar in structure to non-steroidal anti-inflammatory drugs such as aspirin, with anti-inflammatory, anti-tumor and anti-proliferative effects. ABzOH can not only inhibit the express... | |||
T11079 | NMI 8739 | n-docosahexaenoyl dopamine,Dha-DA conjugate | Dopamine Receptor |
T7606 | Guanosine 5'-diphosphate disodium salt | 5'-GDP-Na2 | Endogenous Metabolite |
Guanosine 5'-diphosphate disodium salt (5'-GDP-Na2) is a nucleoside diphosphate, is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulating the interleukin-6 (IL-6)/stat-3 pathway. | |||
T35593 | Semapimod tetrahydrochloride | CPSI-2364 tetrahydrochloride | TLR , MAPK |
Semapimod tetrahydrochloride (CPSI-2364 tetrahydrochloride) is a synthetic ornithine mitogen-activated protein kinase blocker and pro-inflammatory cytokine production inhibitor that interferes with macrophage and microgl... | |||
T37113 | Z62954982 | ZINC08010136 | Rho |
Z62954982 (ZINC08010136) is a selective inhibitor of Rac1, which stunts the growth and branching of neurons.Z62954982 inhibits Rac1 activation and reduces proliferation, p38 phosphorylation, and IL-6 levels in pulmonary ... | |||
T76727 | Teprotumumab | R 1507,HZN 001 | TSH Receptor , IGF-1R |
Teprotumumab is a human monoclonal antibody that blocks the IGF-1 receptor (IGF-1R). Teprotumumab binds to the extracellular α-subunit domain ligand of IGF-1R. Teprotumumab inhibits TSH and IGF-1 action in fibrocytes. Te... | |||
T63067 | Emprumapimod | PF-07265803,ARRY-371797 | p38 MAPK |
Emprumapimod (PF-07265803) is an orally active and specific inhibitor of mitogen-activated protein kinase p38α MAPK, inhibits LPS-induced production of IL-6, and can be used to study dilated cardiomyopathy induced by the... | |||
T64359 | Anti-inflammatory agent 36 | Immunology/Inflammation related | |
Anti-inflammatory agent 36 is an anti-inflammatory agent. It exhibited dose-dependent inhibition of LPS-induced release of TNF-a and IL-6 in active RAW 264.7 mouse macrophages, IC50=3.69uM and 3.68uM, respectively. | |||
T12781 | RV01 | Others | |
RV01 is a novel quinoline-substituted analogue of resveratrol that inhibits DNA damage, reduces ethanol-induced acetaldehyde dehydrogenase (ALDH2) mRNA expression, and has hydroxyl radical scavenging activity. rV01 reduc... | |||
T76711 | Golimumab | MK-8259,SCH 900259,CNTO-148 | TNF |
Golimumab (CNTO-148) is a potent humanized anti-TNFα IgG1κ monoclonal antibody.Golimumab has anti-inflammatory and anticancer activity, inhibits the production of IL-6 and IL-1β, and induces apoptosis.Golimumab can be us... | |||
T25150 | BI-69A11 | BI 69A11,(E)-3-(1H-Benzo[d]imidazol-2-yl)-1-(6-chloro-2-hydroxy-4-phenylquinolin-3-yl)prop-2-en-1-one | NF-κB , Akt |
BI-69A11 ((E)-3-(1H-Benzo[d]imidazol-2-yl)-1-(6-chloro-2-hydroxy-4-phenylquinolin-3-yl)prop-2-en-1-one) is a dual AKT and NFkB pathway inhibitor. It enhances the susceptibility of colon cancer cells to mda-7/IL-24-induce... | |||
T13063 | T6167923 | MyD88 | |
T6167923 is a potent, selective inhibitor of MyD88-dependent signaling pathways. It achieves this by directly binding to the Toll/IL1 receptor (TIR) domain of MyD88, preventing MyD88 homodimer formation. Subsequently, T6... | |||
T84309 | MAO-B-IN-30 | MAO , TNF , NF-κB | |
MAO-B-IN-30 is a selective and potent MAO-B inhibitor that crosses the blood-brain barrier with antiproliferative activity and inhibits both MAO-A and MAO-B.MAO-B-IN-30 reduces the levels of TNF-alpha, IL-6, and NF-kB in... | |||
T3537 | GSK583 | RIP kinase | |
GSK583 is a highly effective and specific RIP2 kinase inhibitor (IC50: 5 nM). | |||
T32114 | Hydrocortisone aceponate | Suniderma,Efficort,Hydrocortisone 17-propionate 21-acetate | Glucocorticoid Receptor |
Hydrocortisone aceponate (Hydrocortisone 17-propionate 21-acetate) is an effective topical glucocorticoid used in the form of a cream to treat various skin diseases. | |||
T2548 | Diflorasone | Glucocorticoid Receptor | |
Diflorasone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive properties. Like other glucocorticoids, diflorasone enters the cell by diffusion across the cell membrane and binds to the glucocorti... | |||
T9948 | NecroX-7 | LC-280126,LC28-0126,LC28 0126 | NADPH-oxidase |
NecroX-7 (LC-280126) is a potent free radical scavenger and a HMGB1 (high-mobility group box 1) inhibitor. NecroX-7 can be used as an antidote to acetaminophen toxicity. NecroX-7 exerts a protective effect by preventing ... | |||
T15017 | CU-T12-9 | TLR | |
CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay). It acts by activating the NFkB pathway, upregulating proinflammatory cytokines, and enhancing TLR1 and TLR2 dimerization.CU-T12-9 activat... | |||
T6838 | FLLL32 | Apoptosis , JAK , STAT | |
FLLL32 is an effective JAK2/STAT3 inhibitor (IC50 of <5 μM). |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
TN6739 | Angoline | 6-Methoxyldihydrochelerythrine | IL Receptor , STAT |
Angoline (6-Methoxyldihydrochelerythrine) hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor(IC50 : 11.56 μM). It inhibits STAT3 phosphorylation and its target gene expression, and inhibits can... | |||
TN6722 | Terminolic acid | 2α,6β,23-trihydroxyl oleanolic acid | Antibacterial |
Terminolic acid (2α,6β,23-trihydroxyl oleanolic acid) is a pentacyclic triterpenoid glucoside isolated from Combretum racemosum, can inhibit the pro-inflammatory cytokines by binding to receptor active site of IL-1β and ... | |||
T2893 | Muscone | 3-Methylcyclopentadecanone,Methylexaltone | MMP , TNF , NF-κB , NOD-like Receptor (NLR) , P-gp , Interleukin |
Muscone (3-Methylcyclopentadecanone) is an organic compound that is the primary contributor to the odor of musk. | |||
TN1520 | Isoforskolin | Coleonol B | IL Receptor , TNF |
Isoforskolin is derived from Coleus forskohlii and reduces the secretion of TNF-α, IL-1β, IL-6 and IL-8 in human mononuclear leukocytes. Isoforskolin can be used in studies about the treatment of Lyme arthritis. | |||
T40660 | Kansuinine B | IL Receptor , SARS-CoV | |
Kansuinine B inhibits Stat3 activation induced by IL-6. Kansuinine B exhibits anti-viral activity and could be used in COVID-19 research. | |||
TN6393 | Fulvotomentoside A | Others | |
Fulvotomentoside A could decrease overexpression of IL-6 and IL-17A, and increase the expression of specific transcription factor Foxp3 of regulatory T cells significantly in intestine. It may be one of the mechanisms th... | |||
TQ0218 | Deoxyandrographolide | 14-deoxyandrographolide | IL Receptor , TNF |
TN6778 | Umbelliprenin | 7-[[(2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrienyl]oxy]-2H-1-benzopyran-2-oneUmbelliprenin | IL Receptor |
Umbelliprenin (7-[[(2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrienyl]oxy]-2H-1-benzopyran-2-oneUmbelliprenin) alleviated neuropathic pain, and decreased serum IL-6 levels and oxidative stress. | |||
TN4379 | Kansuinine A | IL Receptor , STAT , Interleukin | |
Kansuinine A possesses analgesic props, it also shows NGF inducing activity. | |||
T1048 | Estradiol | E2,17β-Estradiol,17β-Oestradiol,β-Estradiol | Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Endogenous Metabolite |
Estradiol (E2) is a naturally occurring steroidal sex hormone that is essential for female fertility and maintenance of secondary sexual characteristics. Estradiol upregulates IL-6 expression through estrogen receptor be... | |||
TN1154 | Nepetin | 6-Methoxyluteolin | Calcium Channel , Histamine Receptor |
Nepetin (6-Methoxyluteolin) has antioxidant activity, it is a potent inhibitor of histamine release and calcium influx via down-regulation of the FcεRI α chain. | |||
T6S1597 | Mulberroside A | TNF , Tyrosinase , Interleukin | |
1. Mulberroside has nephroprotective, hypoglycemic, and antidiabetic effects. 2. Mulberroside A is a glycosylated stilbene of oxyresveratrol; thus, the deglycosylation of Mulberroside A resulted in enhanced inhibition of... | |||
T6S0139 | Neobavaisoflavone | Apoptosis , DNA/RNA Synthesis | |
1. Neobavaisoflavone is isolated as a DNA polymerase inhibitor. 2. Neobavaisoflavone might be a potential anabolic agent to treat bone loss-associated diseases. 3. Neobavaisoflavone has anti-inflammatory activity, can si... | |||
T3809 | Liriope muscari baily saponins C | Others | |
Liriope muscari baily saponins C has an anti-thrombotic activity due to down-regulation of the increased mRNA expression levels of TF and IL-6. | |||
T2791 | Pectolinarin | Apoptosis , Others , NO Synthase , Prostaglandin Receptor , Interleukin | |
Pectolinarin is a Cirsium isolate with anti-inflammatory activity. | |||
T5S1981 | Alpha-Cyperone | (+)-α-Cyperone,α-Cyperone | Others , Endogenous Metabolite |
1. alpha-Cyperone (α-Cyperone) is a promising inhibitor of Hla production by S. aureus and protects lung cells from this bacterium. 2. alpha-Cyperone significantly inhibited PGE2 production by suppressing the LPS-induced... | |||
T4S0145 | Corylifol A | Corylinin | hCE , STAT , UGT |
1. Corylifol A (Corylinin) displays cytotoxic activity against HepG2 and Hep3B hepatocellular carcinoma cell lines, with IC50 values of 4.6 and 13.5 ug/ml, respectively. 2. Corylifol A and Biochanin A can be the potentia... | |||
T2758 | Madecassic acid | 6-Deoxy-L-Galactose,L-Fucose,Brahmic acid,L-fucopyranose | Others , TNF , COX , NO Synthase , Interleukin |
Madecassic acid (L-fucopyranose) is extracted from the whole herb of Centella asiatica. | |||
T2932 | Ginsenoside Rh1 | Sanchinoside B2,Prosapogenin A2,20(S)-Ginsenoside Rh1,Sanchinoside Rh1 | IL Receptor , TNF , Endogenous Metabolite , PPAR , Interleukin |
Ginsenoside Rh1 (Sanchinoside B2) , one of the main constituents of Panax ginseng, exhibits anti-inflammatory effect. | |||
T3662 | Eleutheroside E | NF-κB | |
Eleutheroside E has anti-inflammatory effects by inhibiting NF-κB activities. Eleutheroside E significantly decreases the inflammatory cell infiltration, pannus formation, cartilage damage, bone erosion of CIA mice, the ... | |||
T7210 | Guanosine 5'-diphosphate | GDP | Endogenous Metabolite |
Guanosine 5'-diphosphate (GDP) as Potential Iron Mobilizer, Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway. | |||
T3816 | Velutin | NF-κB , HIF/HIF Prolyl-Hydroxylase | |
Velutin shows the strongest inhibitory effect in NF-κB activation and exhibits the greatest effects in blocking the degradation of inhibitor of NF-κB as well as in inhibiting mitogen-activated protein kinase p38 and JNK ... | |||
Fr14115 | α-Terpineol | Terpineol | IL Receptor , Anti-infection , Antibacterial |
Terpineol possesses antifungal activity against Trichophyton mentagrophytes, it also exhibits strong antimicrobial activity against periodontopathic and cariogenic bacteria. α-Terpineol (Terpineol) shows anticonvulsant, ... | |||
T8033 | Sodium Thiocyanate | Others , Reactive Oxygen Species , Interleukin | |
Sodium Thiocyanate, one of the main sources of the thiocyanate anion, is used as a precursor for the synthesis of pharmaceuticals and other specialty chemicals. | |||
TN1410 | Asperulosidic acid | ASPA | ERK , NF-κB |
Asperulosidic acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities. ASPA is related to the inhibition of inflammatory cytokines (TNF-α, IL-6) and mediators via suppression of the NF-κB and mitogen-a... | |||
T8152 | 6-Demethoxytangeretin | MAPK , ALK | |
6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus depressa. | |||
T5S0167 | Atractylenolide I | IL Receptor , TNF , TLR , JAK , STAT | |
1. Atractylenolide-I has an anti-inflammatory effect by inhibiting TNF-α and IL-6 production; ameliorates sepsis syndrome, liver and kidney functions by reduction of pro-inflammatory cytokines and LPS. 2. Atractylenolide... | |||
T0798 | Triamcinolone | Fluoxyprednisolone,Aristocort,Rodinolone | Glucocorticoid Receptor , COX |
Triamcinolone (Aristocort) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. Upon cell entry, triamcinolone binds to and activates the glucocorticoid receptor, which leads to transloca... | |||
TN5171 | Tricetin | Apoptosis , Others , Nrf2 | |
Tricetin is a flavonoid isolated from pomegranate.Tricetin is a potent competitive inhibitor of Keap1-Nrf2 protein-protein interaction (PPI) and protects Parkinson's disease patients from 6-OHDA-induced neurotoxicity by ... | |||
T3926 | Echinatin | Retrochalcone | Free radical scavengers |
Echinatin (Retrochalcone) disturb the mitochondrial energy transfer reactions and membrane permeability, at a low concentration cause deterioration of respiratory control and oxidative phosphorylation of isolated rat liv... | |||
T3398 | Icaritin | Anhydroicaritin,Cycloicaritin | Apoptosis , JAK , STAT , Autophagy |
Icaritin (Anhydroicaritin) has hormone regulation activity and cardiovascular function improvement activity. Icaritin has anticancer activity, can induce S phase arrest and apoptosis, inhibit ENKL cell proliferation. Ica... | |||
T4S2063 | Tetrahydrocoptisine | STYLOPINE | ERK , p38 MAPK , NF-κB |
1. Tetrahydrocoptisine (STYLOPINE) has effective effects in suppressing inflammation. 2. Tetrahydrocoptisine possesses a protective effect on LPS-induced ALI through inhibiting of NF-κB signaling pathways, which may invo... | |||
TJS0338 | 4-Methylesculetin | 4-Methyl-6,7-dihydroxycoumarin,Methylesculetin | Antioxidant , Glutathione Peroxidase |
4-Methylesculetin (Methylesculetin) is one of the coumarin derivatives with great anti-oxidant and anti-inflammatory activities. | |||
T3803 | Specnuezhenide | Nuzhenide,Nuezhenide | Others , NF-κB , Wnt/beta-catenin |
Specnuezhenide (Nuezhenide) significantly protects human neuroblastoma SH-SY5Y cells from 6-hydroxydopamine-induced neurotoxicity.Nuezhenide is the main inhibitory compound of fruits, it shows a clear inhibitory effect t... | |||
T6S1315 | Oroxylin A | 6-Methoxybaicalein,Baicalein 6-methyl ether | Virus Protease , HIF/HIF Prolyl-Hydroxylase , Autophagy |
1. Oroxylin A (Baicalein 6-methyl ether) has various anti-tumor effects including apoptosis, cell cycle arrest, drug-resistant reversion. 2. Oroxylin A possesses abilities of inhibiting the ATRA-induced IL-6 production v... | |||
T6S1049 | Wilforine | ATPase | |
Wilforine is a sesquiterpene pyridine alkaloid; important bioactive compound in T. wilfordii plants, and is effective in treating idiopathic pulmonary fibrosis. Wilforine has anti-inflammatory effect, which might be medi... | |||
T4S1422 | Praeruptorin E | Others , Calcium Channel | |
1. Praeruptorin C and E can relax swine coronary artery and decrease contractility in guinea-pig left atria, these effects are similar in many respects to those displayed by drugs that have calcium entry blocking activit... | |||
T4115 | Auraptene | 7-geranyloxycoumarin | MMP , BACE |
Auraptene is a coumarin derived from citrus plants that bears a geranyloxyl moiety at its C-7. It has anti-inflammatory, anti-carcinogenic, anti-bacterial, neuroprotective, and hepatoprotective activities. It inhibits le... | |||
T3744 | Veratric acid | Veratrumenoic acid,3,4-Dimethoxybenzoic acid | Reactive Oxygen Species , COX |
Veratric acid (3,4-Dimethoxybenzoic acid) is a simple benzoic acid derived from plants and fruits with anti-oxidant, anti-inflammation and blood pressure-lowering effects. | |||
T6S1917 | Schisandrol B | Gomisin A,TJN-101,Besigomsin,Gamma-Schisandrin,Schizandrol B,Wuweizi alcohol-B | P450 , Reactive Oxygen Species , Autophagy |
1. Schisandrol B (Besigomsin) may exert neuroprotective effects by attenuating the microglia-mediated neuroinflammatory response via inhibiting the TLR4-mediated NF-κB and MAPKs signaling pathways. 2. Schisandrol B has a... | |||
T2S0843 | Negletein | 7-O-Methylbaicalein,Baicalein-7-methylether | IL Receptor , TNF , NOS , Interleukin |
1. Negletein (7-O-Methylbaicalein) has anti-inflammatory and immunomodulatory activities via inhibition of TNF-α, iNOS and IL-1β. 2. Negletein as a neuroprotectant enhances the action of nerve growth factor and induces n... | |||
T6S1141 | Ganoderic acid A | Apoptosis , NF-κB , Endogenous Metabolite , Autophagy | |
1. Ganoderic acid A exhibits antitumor activity, mediated through its inhibitory effect on nuclear transcription factor-kappaB and activator protein-1. 2. Ganoderic acid A can induce proliferation inhibition, apoptosis a... | |||
T2S2264 | Linalool | Linalol,(±)-Linalool,Phantol | Apoptosis , IL Receptor , TNF , Endogenous Metabolite , iGluR |
1. Linalool (Linalol), a natural compound of the essential oils, has been shown to have antinociceptive, antimicrobial, and anti-inflammatory properties. 2. Linalool was protected against LPS/GalN-induced liver injury th... | |||
T5558 | Chelidonic acid | Jervaic acid,Jerva acid,γ-Pyrone-2,6-dicarboxylic acid | NF-κB , Caspase |
Chelidonic acid (Jervaic acid) is a component of Chelidonium majus L., used as a mild analgesic, an antimicrobial, an acentral nervous system sedative. Chelidonic acid (Jervaic acid) also shows anti-inflammatory activity... | |||
T3893 | Forsythoside B | TNF , NF-κB | |
Forsythoside B binds to LPS and reduces the biological activity of serum LPS, and inhibits NF-κB activation. Forsythoside B inhibits the inflammatory response and has antioxidant properties. Potent neuroprotective effect... | |||
T26545 | Acanthoic acid | NP1302,NP 1302: NP-1302 | |
Acanthoic acid is a pimaradiene diterpene isolated from Acanthopanax koreanum with anti-inflammatory activities. Acanthoic acid downregulates LPS-induced IL-1β, IL-6 and TNF-α production in BALF, attenuates lung histopat... | |||
TN1458 | Buddlejasaponin IV | PARP , Akt , Chk | |
Buddlejasaponin IV has analgesic and anti-inflammatory effects, the inhibitions of the expressions of iNOS, COX-2, TNF-alpha, IL-1beta and IL-6 by blocking NF-kappaB activation. | |||
T11034 | Di-O-methyldemethoxycurcumin | IL Receptor | |
Di-O-methyldemethoxycurcumin is a Curcumin analog isolated from medicinal plant turmeric di-orthomethyldemethoxycurcumin, anti-inflammatory and antioxidant properties Inhibition of IL-6 production, EC50 is 16.20μg/mL. | |||
T75674 | Pedunculagin | Others | |
Pedunculagin, a potent 5α-reductase type 1 inhibitor, effectively inhibits the production of nitric oxide (NO), IL-6, and IL-8 while also decreasing the protein expression of 5α-reductase. Additionally, it exhibits anti-... | |||
TMA2576 | Episappanol | IL Receptor , TNF | |
Episappanol has anti-inflammatory activity , it can significantly inhibit the secretion of the pro-inflammatory cytokines interleukin (IL-6) and tumor necrosis factor-alpha (TNF-α). | |||
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カタログ番号 | 製品名 | Species | Expression System |
---|---|---|---|
TMPY-03238 | IL-6 Protein, Mouse, Recombinant | Mouse | E. coli |
IL-6 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 21.9 kDa and the accession number is P08505. | |||
TMPY-00863 | IL-6 Protein, Human, Recombinant | Human | E. coli |
IL-6 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 20.95 kDa and the accession number is P05231. | |||
TMPY-00864 | IL-6R Protein, Human, Recombinant (His) | Human | HEK293 Cells |
IL-6R Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40 kDa and the accession number is A0N0L5. | |||
TMPY-05278 | IL-6R Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
IL-6R Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 65.3 kDa and the accession number is A0N0L5. | |||
TMPY-01214 | IL-6R Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
IL-6R Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39 kDa and the accession number is P22272. | |||
TMPY-03327 | IL-6 Protein, Rhesus, Recombinant | Rhesus | E. coli |
IL-6 Protein, Rhesus, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 21 kDa and the accession number is A0A1D5QRZ4. | |||
TMPY-03298 | IL-6 Protein, Rat, Recombinant | Rat | E. coli |
IL-6 Protein, Rat, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 21.9 kDa and the accession number is A6KJN3. | |||
TMPY-03802 | IL-17F Protein, Human, Recombinant (aa 31-163) | Human | E. coli |
IL-17F Protein, Human, Recombinant (aa 31-163) is expressed in E. coli expression system. The predicted molecular weight is 15.1 kDa and the accession number is AAH70124.1. | |||
TMPY-01076 | Gp130/IL6ST Protein, Human, Recombinant (His & hFc) | Human | HEK293 Cells |
gp130/IL6ST Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 96 kDa and the accession number is P40189-1. | |||
TMPK-00101 | IL-6 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
IL-6 (Interleukin-6) is a pleiotropic cytokine that acts in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression.Interleukin 6 has been shown to interact with interleukin-6 recep... | |||
TMPY-02879 | IL-36 alpha/IL-1F6 Protein, Human, Recombinant (aa 6-158) | Human | E. coli |
IL-36 alpha/IL-1F6 Protein, Human, Recombinant (aa 6-158) is expressed in E. coli expression system. The predicted molecular weight is 17.2 kDa and the accession number is Q9UHA7. | |||
TMPY-02603 | STAT6 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that is activated by interleukin-4 (IL-4)-induced tyrosine phosphorylation and mediates most of the IL-4-induced gene expression. STAT6... | |||
TMPK-00646 | Gp130/IL6ST Protein, Rhesus macaque, Recombinant (His) | Rhesus | HEK293 Cells |
gp130 is a common signal transducing component of the functional receptor complexes for the interleukin (IL)-6 family of cytokines, ie, IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M, ciliary neurotrophic fa... | |||
TMPK-00412 | Gp130/IL6ST Protein, Human, Recombinant (His) | Human | HEK293 Cells |
gp130 is a common signal transducing component of the functional receptor complexes for the interleukin (IL)-6 family of cytokines, ie, IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M, ciliary neurotrophic fa... | |||
TMPY-05640 | IL-6R Protein, Human, Recombinant, Biotinylated | Human | HEK293 Cells |
IL-6R Protein, Human, Recombinant, Biotinylated is expressed in HEK293 mammalian cells. The predicted molecular weight is 67.1 kDa and the accession number is A0N0L5. | |||
TMPY-06297 | IL-6R Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells |
IL-6R Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 41.80 kDa and the accession number is A0N0L5. | |||
TMPJ-00291 | IL-6R alpha/CD126 Protein, Human, Recombinant (Avi & His), Biotinylated | Human | HEK293 Cells |
Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. IL6Ra is a part of the receptor for interleukin 6 cytokine. IL6Ra binds to... | |||
TMPK-00042 | IL-17F Protein, Mouse, Recombinant (His & Avi), Biotinylated | Mouse | HEK293 Cells |
IL-17F Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 17.8 kDa and the accession number is Q7TNI7-1. | |||
TMPK-00041 | IL-17F Protein, Mouse, Recombinant (His & Avi) | Mouse | HEK293 Cells |
IL-17F Protein, Mouse, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 17.8 kDa and the accession number is Q7TNI7-1. | |||
TMPK-00046 | IL-17F Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells |
IL-17F Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 17.5 /14.9 kDa and the accession number is Q96PD4. | |||
TMPJ-00194 | IL-20RB Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Interleukin-20 receptor subunit beta(IL20RB) is a single-pass type I membrane protein and belongs to the type II cytokine receptor family. It contains 2 fibronectin type-III domains. There are two kinds of type II cytoki... | |||
TMPY-05461 | IL-17F Protein, Human, Recombinant (His), Biotinylated | Human | HEK293 Cells |
IL-17F Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 73.3 kDa and the accession number is Q96PD4. | |||
TMPH-03208 | IL-6 Protein, Rabbit, Recombinant (His) | Rabbit | P. pastoris (Yeast) |
IL-6 Protein, Rabbit, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 26.4 kDa and the accession number is Q9MZR1. | |||
TMPY-06039 | Gp130/IL6ST Protein, Human, Recombinant (aa 1-618, DDDDK) | Human | HEK293 Cells |
gp130/IL6ST Protein, Human, Recombinant (aa 1-618, DDDDK) is expressed in HEK293 mammalian cells. The predicted molecular weight is 68.4 kDa and the accession number is P40189-1. | |||
TMPY-01898 | IL-17F Protein, Human, Recombinant (aa 31-163, His) | Human | HEK293 Cells |
IL-17F Protein, Human, Recombinant (aa 31-163, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.2 kDa and the accession number is Q96PD4. | |||
TMPK-00289 | IL-6R alpha/CD126 Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells |
The multifunctional factor interleukin 6 (IL-6) exerts its activities through binding to a high-affinity receptor complex consisting of two membrane glycoproteins: an 80 kDa component receptor that binds IL-6 with low af... | |||
TMPY-00387 | Gp130/IL6ST Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
gp130/IL6ST Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 94.4 kDa and the accession number is AAA59155.1. | |||
TMPY-06745 | Gp130/IL6ST Protein, Human, Recombinant (mFc) | Human | HEK293 Cells |
gp130/IL6ST Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 94.11 kDa and the accession number is AAA59155.1. | |||
TMPY-05559 | IL-20RB Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
IL-20RB Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 23.9 kDa and the accession number is Q6UXL0-1. | |||
TMPY-04183 | IL-6 Protein, Sus scrofa (Pig), Recombinant | Sus scrofa (Pig) | E. coli |
IL-6 Protein, Sus scrofa (Pig), Recombinant is expressed in E. coli expression system. The predicted molecular weight is 21.2 kDa and the accession number is A4D862. | |||
TMPH-03500 | IL-6 Protein, Sheep, Recombinant (GST) | Sheep | E. coli |
IL-6 Protein, Sheep, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 47.5 kDa and the accession number is P29455. | |||
TMPJ-01172 | IL-17 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. Mature mouse IL-17A shares 61% and 89% amino acid seque... | |||
TMPY-06981 | IL-1 alpha/IL-1A Protein, Human, Recombinant (E. coli) | Human | E. coli |
IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proli... | |||
TMPJ-01467 | Oncostatin M/OSM Protein, Human, Recombinant (E. coli, His) | Human | E. coli |
Oncostatin M (OSM) is a glycoprotein belonging to the interleukin-6 family of cytokines that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. OSM encodes a growth regulator, ... | |||
TMPH-01578 | KRT18 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Involved in the uptake of thrombin-antithrombin complexes by hepatic cells. When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT... | |||
TMPK-01202 | CD93/C1qR1 Protein, Human, Recombinant (His&Avi), Biotinylated | Human | HEK293 Cells |
CD93 has been shown critical roles in inflammatory and immune diseases. CD93 silencing increased IL-6 and TSLP, but not IL-33 levels in culture supernatants. HDM-induced asthma mice showed significant airway hyperrespons... | |||
TMPK-01096 | IL-31RA Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Interleukin-31 receptor A (IL-31RA) is a newly identified type I cytokine receptor, that is related to gp130, the common receptor of the interleukin (IL) -6 family cytokines. IL-31RA forms a functional receptor complex f... | |||
TMPK-01113 | IL-31RA Protein, Human, Recombinant (aa 20-519, hFc) | Human | HEK293 Cells |
Interleukin-31 receptor A (IL-31RA) is a newly identified type I cytokine receptor, that is related to gp130, the common receptor of the interleukin (IL) -6 family cytokines. IL-31RA forms a functional receptor complex f... | |||
TMPH-01464 | HNRNPM Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling ... | |||
TMPY-00493 | IL-19 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
The molecular features at the IL19 locus may modestly alter the establishment of HIV-1 infection. Interleukin (IL) 19, IL-20, and IL-24 belong to the IL-10 cytokine family and have been identified to play a role in the r... | |||
TMPJ-00079 | IL-11 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
Interleukin-11(IL-11) is a secreted protein and belongs to the IL-6 superfamily. IL-11 has been demonstrated to improve platelet recovery after chemotherapy-induced thrombocytopenia, induceacute phase proteins, modulate ... | |||
TMPJ-01237 | IL-17D Protein, Human, Recombinant | Human | E. coli |
The Interleukin-17 family proteins, comprising six members (IL-17, IL-17B through IL-17F),are secreted, structurally related proteins that share a conserved cysteine-knot fold near the C-terminus, but have considerable s... | |||
TMPK-01114 | IL-31RA Protein, Human, Recombinant (aa 20-519, His) | Human | HEK293 Cells |
Interleukin-31 receptor A (IL-31RA) is a newly identified type I cytokine receptor, that is related to gp130, the common receptor of the interleukin (IL) -6 family cytokines. IL-31RA forms a functional receptor complex f... | |||
TMPJ-01444 | IL-17A Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. As IL-17 shares properties with IL-1 and TNF-alpha, it ... | |||
TMPY-01033 | IL-32 Protein, Human, Recombinant (isoform alpha, His) | Human | HEK293 Cells |
IL-32 is a recently discovered cytokine that induces various proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6) and chemokines in both human and mouse cells through the NF-kappaB and p38 MAPK inflammatory signal pathw... | |||
TMPH-01577 | KRT18 Protein, Human, Recombinant (E. coli, His) | Human | E. coli |
Involved in the uptake of thrombin-antithrombin complexes by hepatic cells. When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT... | |||
TMPJ-00047 | IL-31 Protein, Human, Recombinant | Human | E. coli |
Human Interleukin 31 (IL-31) is a cytokine containing a four-helix bundle structure. It shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. Human IL-31 cDNA encodes... | |||
TMPJ-00968 | NAMPT Protein, Human, Recombinant (His) | Human | E. coli |
Pre-B cell colony enhancing factor (PBEF) was originally identified as a cytokine that potentiated the clonal expansion and differentiation of pre-B cells, but it is also acknowledged to be the ubiquitous intracellular e... | |||
TMPH-03345 | Oncostatin M/OSM Protein, Rat, Recombinant (His) | Rat | HEK293 Cells |
Growth regulator. Inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses only type II OSM receptor (heterodimers compos... | |||
TMPY-05353 | CCL26 Protein, Human, Recombinant | Human | Baculovirus Insect Cells |
The eotaxin subfamily of CC chemokines consists of eotaxin-1/CCL11, eotaxin-2/CCL24 and eotaxin-3/CCL26. All eotaxins induce the trafficking of eosinophils to the sites of inflammation via CC chemokine receptor 3 (CCR3),... | |||
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カタログ番号 | 製品名 | ||
---|---|---|---|
L3800 | NF-κB Signaling Compound Library | 729 compounds | |
A unique collection of 729 compounds targeting NF-κB signaling for high throughput screening and high content screening; | |||
L7600 | Chemokine Inhibitor Library | 59 compounds | |
A unique collection of 59 chemokines or chemokine receptors targeted compounds for high throughput and high content screening; |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T36408 | Rhein-13C4 | Rhein-13C4 | |
Rhein-13C4 is intended for use as an internal standard for the quantification of rhein by GC- or LC-MS. Rhein is an anti-inflammatory anthraquinone found in rhubarb and is the bioactive derivative of its prodrug diacerei... | |||
T71285 | Metaxalone-d6 | ||
Metaxalone-d6 is intended for use as an internal standard for the quantification of metaxalone by GC-or LC-MS. Metaxalone is a skeletal muscle relaxant. It inhibits the proliferation of, and induces apoptosis in, RAW 264... | |||
T71212 | Lornoxicam-d4 | ||
Lornoxicam-d4 is intended for use as an internal standard for the quantification of lornoxicam by GC- or LC-MS. Lornoxicam is a COX inhibitor and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and an... | |||
T71328 | Theobromine-d6 | ||
Theobromine-d6 is intended for use as an internal standard for the quantification of theobromine by GC- or LC-MS. Theobromine is a methylxanthine alkaloid and derivative of caffeine that has been found in cocoa beans and... |