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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T80055 | Beta-glucuronidase (bovine liver) | ||
Beta-glucuronidase, a critical lysosomal enzyme, is implicated in the breakdown of glucuronate-containing glycosaminoglycans [1]. | |||
T81944 | LEAP-2 | Human liver expressed antimicrobial peptide-2 | |
LEAP-2 (Liver-expressed antimicrobial peptide 2) is a peptide of human origin with antimicrobial properties, initially identified in blood [1]. | |||
T16930 | SR9238 | Liver X Receptor | |
SR9238 is a synthetic agonist of liver X receptor inverse (IC50s: 214 nM and 43 nM for LXRα and LXRβ, respectively). | |||
T15427 | GSK2033 | Liver X Receptor | |
GSK2033 is an antagonist of LXR (pIC50s: 7 and 7.4 for LXRα or LXRβ, respectively). | |||
T1801 | SR9243 | Liver X Receptor | |
SR9243, an LXR inverse agonist, can induce LXR-corepressor interaction; shows anticancer activity and selectively targets the lipogenesis and Warburg effect. | |||
T5178 | AZ876 | Liver X Receptor | |
AZ876 is a potent, highly selective LXR agonist with Ki/EC50 of 7/6 nM and 11/73 nM for hLXRα and hLXRβ respectively. | |||
T6347 | Ki16198 | LPA Receptor , LPL Receptor | |
Ki16198 is the methyl ester of Ki16425, which is a LPA antagonist and inhibits LPA1- and LPA3-induced inositol phosphate production with Ki of 0.34 μM and 0.93 μM, respectively, shows weaker inhibition for LPA2, no activ... | |||
T11991 | Mefentrifluconazole | P450 , Antifungal | |
Mefentrifluconazole is a potent, selective and orally active fungal CYP51 (Kd= 0.5 nM) inhibitor, but shows less inhibitory activity on human aromatase (IC50=0.92 μM). Mefentrifluconazole is a novel azole derivative and ... | |||
T12580 | PTUPB | COX , Epoxide Hydrolase | |
PTUPB is a potent and dual inhibitor of sEH and COX-2 enzymes(IC50 of 0.9 nM and 1.26 μM, respectively). | |||
T11428 | Glyco-Obeticholic acid | FXR | |
Glyco-Obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is an agonist of the farnesoid X receptor (FXR). | |||
T9215 | ELOVL6-IN-2 | Others | |
ELOVL6-IN-2 is a orally active and selective ELOVL6 inhibitor. | |||
T3633 | Crenigacestat | LY3039478 | Gamma-secretase |
Crenigacestat (LY3039478) is an orally bioavailable Notch inhibitor with an IC50 of ~1 nM in most of the tumor cell lines tested. Crenigacestat effectively inhibits mutant Notch receptor activity. In a xenograft tumor mo... | |||
T2601 | Vidofludimus | SC12267,4sc-101 | Dehydrogenase , DNA/RNA Synthesis , Interleukin |
Vidofludimus (SC12267) (4SC-101, SC12267) is a novel small molecule inhibitor of dihydroorotate dehydrogenase (DHODH). | |||
T15371 | Gardiquimod | TLR , HIV Protease | |
Gardiquimod is a TLR7/8 agonist. When used at concentrations below 10 μM, Gardiquimod specifically activates TLR7. Gardiquimod could inhibit HIV-1 infection of macrophages and activated peripheral blood mononuclear cells... | |||
T10904 | CWP232228 | Wnt/beta-catenin | |
CWP232228, a potent and selective Wnt / β-catenin signaling inhibitor, antagonizes the binding of β-catenin to T-cell factor (TCF) in the nucleus. CWP232228 inhibits the formation and metastasis of tumors by inhibiting t... | |||
T27478 | GSK3987 | Liver X Receptor | |
GSK3987 is an LXR ligand. GSK3987 recruits the steroid receptor coactivator-1 to human LXRalpha and LXRbeta with EC50s of 40 nM. | |||
T7768 | RGX-104 | RGX-104 free Acid | Liver X Receptor |
RGX-104 (RGX-104 free Acid) free Acid is an agonist of potent liver-X nuclear hormone receptor (LXR) | |||
T1115 | Doxylamine succinate | Decapryn | Histamine Receptor |
Doxylamine Succinate is a pyridine derivate histamine H1 antagonist with pronounced sedative properties. Doxylamine succinate (Decapryn) competitively blocks the histamine H1 receptor and limits the typical allergic and ... | |||
T0456 | Cinchophen | Cinconal | COX |
Cinchophen (Cinconal), an analgesic drug, is utilized in treating gout. | |||
T5421 | KDU691 | Parasite , PI4K | |
KDU691 is a PI4K inhibitor. | |||
T6310 | GW3965 hydrochloride | GW3965 HCl | Liver X Receptor |
GW3965 hydrochloride (GW3965 HCl) is an effective and specific LXR agonist for hLXRα/β (EC50: 190/30 nM). | |||
T6031 | GNE0877 | GNE 0877,GNE-0877 | LRRK2 |
GNE0877 (GNE 0877) is a highly effective and specific leucine-rich repeat kinase 2 (LRRK2) inhibitor (Ki: 0.7 nM). | |||
T1783 | LXR-623 | LXR623,WAY 252623 | Liver X Receptor |
LXR-623 (WAY 252623) is an orally bioavailable and highly specifical synthetic modulator of LXR. | |||
T19399 | L-Ornithine L-aspartate | Ornithine Aspartate | Others |
L-Ornithine L-aspartate (Ornithine Aspartate) lowers blood ammonia concentration and to eliminate symptoms of hepatic encephalopathy associated with liver cirrhosis. | |||
T1677 | Montelukast | Singular | Leukotriene Receptor , Lipoxygenase , LTR |
Montelukast (Singular) is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma and has been linked to rare cases of clinically apparent liver injury... | |||
TP2333 | Cyclo(L-Pro-L-Tyr) | Others | |
Maculosin is a secondary metabolite of fungi and bacteria. | |||
T3053 | CZC-25146 | CHEMBL2397014 | LRRK2 |
CZC-25146 (CHEMBL2397014) is an effective, specific and metabolically stable LRRK2 inhibitor with IC50 of 4.76/6.87 nM for wild-type LRRK2(Leucine-rich repeat kinase-2) and G2019S LRRK2, respectively. | |||
T5139 | CZC-25146 hydrochloride | LRRK2 | |
CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2, respectively. | |||
T1677L | Montelukast sodium | MK0476 | Leukotriene Receptor , LTR |
Montelukast sodium (MK0476) is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma and has been linked to rare cases of clinically apparent liver i... | |||
T4190 | Ticlopidine | PCR 5332,Ticlid | ATPase , Adiponectin receptor |
Ticlopidine (PCR 5332) is an antiplatelet drug in the thienopyridine family which is an adenosine diphosphate (ADP) receptor inhibitor. | |||
T8526 | Metformin | 1,1-Dimethylbiguanide | Mitophagy , AMPK , Autophagy |
Metformin (1,1-Dimethylbiguanide) is an AMPK activator with blood-brain barrier permeability. Metformin may improve glycemic control by increasing insulin sensitivity and decreasing intestinal glucose uptake, and is comm... | |||
T12075 | ML-180 | SR1848 | Others |
ML-180 (SR1848) is a potent orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) inverse agonist (IC50 of 3.7 μM) . | |||
T22323 | Enoxaparin sodium | Thrombin | |
Enoxaparin sodium is a low-molecular-weight heparin (LMWH) that has recently been approved by the US FDA for use in patients with medically managed ST-segment myocardial infarction (STEMI), or STEMI with subsequent percu... | |||
T5128 | RGX-104 hydrochloride | SB742881,RGX-104 HCl | Liver X Receptor |
RGX-104 hydrochloride (SB742881) is a liver X receptor (LXR) agonist with potential immunomodulating and antineoplastic activities. It modulates innate immunity via transcriptional activation of the ApoE gene. | |||
T12883 | Fezagepras | PBI-4050,Setogepram | GPR |
Fezagepras (Setogepram) is an orally active GPR40 agonist and is an antagonist or inverse agonist of GPR84 with anti-inflammatory, anti-fibrotic, and anti-proliferative actions. | |||
T8505 | SC-236 | Sc 236 | Apoptosis , COX , PPAR |
SC-236 (Sc 236) is an orally active and selective inhibitor of COX-2 (IC50 of 0.005 μM and 17.8 μM for COX-2 and COX-1, respectively). | |||
T2171 | SEW2871 | SEW2871 | S1P Receptor , LPL Receptor |
SEW 2871 is an orally available, highly selective S1P1 agonist with an EC50 of 13.8 nM.It reduces the number of lymphocytes in the blood and is used in studies related to diabetes, Alzheimer's disease, liver fibrosis, an... | |||
T8364 | Mebrofenin | SQ 26962 | Others |
Mebrofenin (SQ 26962) is available as a ready to use the kit for radio-labeling with Tc-99m.Technetium Tc 99m Mebrofenin is a diagnostic radiopharmaceutical composed of diisopropyl-iminodiacetic acid (DISIDA) attached to... | |||
T8845 | UTL-5g | 3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl-,GBL-5g | TNF |
UTL-5g (3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl-) is a novel potential chemoprotective agent, TNF-α inhibitor that reduces cisplatin-induced side effects including nephrotoxicity, hepatotoxicity and hemat... | |||
T6714 | URB-597 | KDS-4103,FAAH Inhibitor II | Mitophagy , FAAH , Autophagy |
URB-597 (FAAH Inhibitor II) is an effective, orally bioavailable FAAH inhibitor (IC50: 4.6 nM), and no effect on other cannabinoid-related targets. | |||
T1090 | Perphenazine | Perphenazin,Etaperazine,Trilafon | CaMK , Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , Histamine Receptor |
Perphenazine (Trilafon) is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties. | |||
T22443 | Triglycidyl isocyanurate | Tris(2,3-epoxypropyl) Isocyanurate,Teroxirone,TGIC,TGI | Apoptosis |
Triglycidyl isocyanurate (Teroxirone) is a triazene triepoxide with antineoplastic and antiangiogenic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl isocyanurate alk... | |||
T3970 | BMS-779788 | XL652,EXEL04286652,XL 652,XL-652,BMS-788 | Liver X Receptor |
BMS-779788 (XL-652) is an LXRα/β partial agonist (IC50: 68/14 nM). | |||
T9010 | IMM-H007 | Others , AMPK | |
IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expression | |||
T3424 | Ezutromid | BMN 195,VOX-C1100,SMT C1100 | Others |
Ezutromid (BMN 195) is a translation modulator of Small utrophin (EC50: 0.4 uM). Ezutromid is an orally bioavailable small molecule that transcriptionally upregulates the utrophin gene, increasing both utrophin mRNA and ... | |||
T0740 | Metformin hydrochloride | Metformin HCl,1, 1-Dimethylbiguanide hydrochloride,1,1-Dimethylbiguanide hydrochloride | Mitophagy , AMPK , Autophagy |
Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) , a widely used anti-diabetic drug, has a potential function as an anti-Y medicine. It inhibits the proliferation of a variety of Y cells including colon, pro... | |||
T6690 | T0901317 | Apoptosis , FXR , Liver X Receptor , ROR | |
T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB). | |||
T0835 | Tamoxifen Citrate | Tamoxifen Z-isomer citrate,ICI 46474,ICI 46474 Citrate | Apoptosis , Estrogen Receptor/ERR , HSP , Estrogen/progestogen Receptor , Autophagy |
Tamoxifen is an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM). | |||
T1406 | Amantadine hydrochloride | 1-adamantanamine HCl,1-Adamantanamine hydrochloride,Symmetrel,CI-719,Amantadine HCl,1-Adamantylamine hydrochloride | Dopamine Receptor , Influenza Virus |
Amantadine hydrochloride (CI-719) is an antiviral that is used in the prophylactic or symptomatic treatment of influenza A and Parkinson disease. | |||
T6906 | Tamoxifen | ICI 46474,Z-Tamoxifen,trans-Tamoxifen,ICI47699 | Apoptosis , Estrogen Receptor/ERR , HSP , Estrogen/progestogen Receptor , Autophagy |
Tamoxifen (ICI47699) is a selective and orally effective estrogen receptor modulator (SERM). Tamoxifen has both inhibitory (e.g., mammary cells) and activating (e.g., bone, liver, and uterine cells) activity against estr... |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T8254 | Chrysoobtusin | Others | |
Chrysoobtusin belongs to the class of organic compounds known as hydroxyanthraquinones. | |||
T7529 | Yamogenin | Others | |
Yamogenin is a diastereomer of diosgenin, which we have identified as the compound responsible for the anti-hyperlipidemic effect of fenugreek. | |||
T13092 | Tauro-Obeticholic acid | FXR | |
Tauro-Obeticholic acid is an active Obeticholic acid metabolite. Obeticholic acid is an orally bioavailable agonist of farnesoid-X receptor (FXR). | |||
T2768 | Saikosaponin A | NF-κB , Antibacterial , Liver X Receptor | |
Saikosaponin A has a variety of pharmacological benefits, including antiepileptic, anti-osteoporosis, antioxidant, anti-in ammatory, immunomodulatory, and anti-bacterial activities. It can effectively attenuate neuropath... | |||
T4S0878 | Prunetin | Prunusetin | ERK , Dehydrogenase , NF-κB |
1. Prunetin (Prunusetin) significantly reduces serum levels of inflammatory cytokines and mortality in mice challenged with lipopolysaccharide. 2. Prunetin mediates anti-obesity/adipogenesis effects by suppressing obesit... | |||
T5613 | Squalane | Dodecahydrosqualene,Perhydrosqualene | Others |
Squalane (Perhydrosqualene) is a naturally occurring lipid in both plants and animals. It is usually used as a moisturizer and emollient in cosmetics manufacturing. | |||
T8733 | Antrodin A | camphorataanhydride A | Others |
Antrodin A (camphorataanhydride A) (AdA) is one of the main active ingredients in the solid-state fermented A. camphorata mycelium. It protects the liver from alcohol damage by improving the antioxidant and anti-inflamma... | |||
T8117 | Metenolone acetate | Methenolone acetate | Others , Androgen Receptor |
Metenolone acetate (Methenolone acetate) is an androgen and anabolic steroid (AAS) medication which is used mainly in the treatment of anemia due to bone marrow failure. | |||
T13741 | Isoviolanthin | Others | |
Isoviolanthin reduces the migratory and invasive capacities of TGF-β1-treated HCC cells without cytotoxic effects on normal live cells and has potential as a therapeutic agent for the treatment of advanced-stage metastat... | |||
T5S1923 | Schisandrin C | Schizandrin-C,Wuweizisu-C | Apoptosis , Others , Virus Protease |
Schisandrin C (Wuweizisu-C) is a phytochemical lignan isolated from Schizandra chinensis Baill; shows anticancer-effects in human leukemia U937 cells. | |||
TQ0274 | 27-Hydroxycholesterol | 25(R)-27-hydroxy Cholesterol | Estrogen/progestogen Receptor , Liver X Receptor |
T2810 | (20S)-Protopanaxatriol | 20(S)-APPT,g-PPT | Apoptosis , Estrogen Receptor/ERR , Glucocorticoid Receptor , Estrogen/progestogen Receptor , Liver X Receptor |
(20S)-Protopanaxatriol (g-PPT)(g-PPT), a metabolite of ginsenoside, could regulate endothelial cell functions through the estrogen receptor and glucocorticoid receptor. | |||
T3999 | D(+)-Galactosamine hydrochloride | D-Galactosamine HCl | Others |
D(+)-Galactosamine hydrochloride (D-Galactosamine HCl) hepatotoxicity is associated with endotoxin sensitivity and mediated by lymphoreticular cells in mice. | |||
T3673 | Mollugin | Rubimaillin | HER , JAK |
Mollugin (Rubimaillin) may be a JAK2 inhibitor and inhibits LPS-induced inflammatory responses by blocking the activation of the JAK-STAT pathway. Mollugin as a candidate for a chemotherapeutic agent in OSCCs via the upr... | |||
T3324 | Lycorine | Galanthidine,Narcissine,Amarylline,Belamarine,Licorine | Apoptosis , Virus Protease , Antibacterial , AChR , Fatty Acid Synthase |
Lycorine (Narcissine) inhibits protein synthesis and may inhibit ascorbic acid biosynthesis, although studies on the latter are controversial and inconclusive. | |||
T7060 | Amantadine | 1-Aminoadamantane,1-Adamantanamine,1-Adamantylamine | Others |
Amantadine (1-Aminoadamantane) is an antiviral, is a weak antagonist of the NMDA-type glutamate receptor, increases dopamine release, and blocks dopamine reuptake. | |||
T7475 | S-Adenosyl-L-methionine | AdoMet,Ademetionine,SAMe,S-Adenosyl methionine | Others , Endogenous Metabolite |
S-Adenosyl-L-methionine (Ademetionine) is an intermediate metabolite of methionine,for treatment of primary biliary cirrhosis and major depressive disorder. | |||
T35981 | Biliverdin hydrochloride | Antioxidant | |
Biliverdin hydrochloride is a tetrapyrrole water-soluble compound formed from the oxidation of heme, with potential antioxidant activity, involved in the biliverdin-bilirubin redox system. | |||
TN1599 | Eburicoic acid | Eburicoicacid,MFCD00238594,ZINC4655149 | Antioxidant , TNF , NOS , NO Synthase , CCR , Immunology/Inflammation related |
Eburicoic acid (ZINC4655149) exhibits anti-inflammatory and antioxidant activity thereby protecting the liver from CCl4-induced hepatic damage and can be used in studies about anti-liver cancer. | |||
T4035 | Khasianine | Others | |
Khasianine has strong activity against liver damage induced by CCl4. | |||
T24711 | Ricinine | 1,2-Dihydro-4-methoxy-1-methyl-2-oxonicotinonitrile,Ricinin,Ritsinin | Others |
Ricinine (1,2-Dihydro-4-methoxy-1-methyl-2-oxonicotinonitrile) is a major alkaloid in Ricinus communis plant with hepatoprotection in CCl4 -induced liver damage. | |||
TN3548 | Bulleyanin | Others | |
Bulleyanin shows strong inhibition of mouse ehrlich ascites carcinoma (ECA), mouse sarcoma S-180, and mouse liver ascites. | |||
TN1132 | Procyanidin A2 | IL Receptor , TNF , transporter , Antibacterial | |
Procyanidin A2 is a potential precursor of 5-(3',4'-dihydroxyphenyl)-γ-valerolactone, exhibits antioxidant, anti-inflammary, anti-hyperglycemia, and anti-type 2 diabetes activities. Procyanidin A2 demonstrates liver cell... | |||
TWA2417 | Sodium taurocholate | Taurocholate Sodium | Others |
Sodium taurocholate (Taurocholate Sodium) hydrate is the main end product of cholesterol catabolism. During enterohepatic circulation, bile taurocholic acid is converted by the microorganisms to taurodeoxycholic acid and... | |||
T7732 | Carbenoxolone | Biogastrone,Carbenoxolona,Carbenoxolone,Bioral | Dehydrogenase , Gap Junction Protein |
Carbenoxolone (Biogastrone) is an inhibitor of 11β-HSD and gap junction connexin channels. Carbenoxolone inhibits macrophage migration into atria and prevents the development of fatty liver disease. | |||
T3938 | H-HomoArg-OH.HCl | NSC 145416,L-Homoarginine hydrochloride,L(+)-Homoarginine hydrochloride | Endogenous Metabolite , Phosphorylase |
H-HomoArg-OH.HCl (L-Homoarginine hydrochloride) is a specific inhibitor of liver-type alkaline phosphatase. | |||
T8103 | H-HoArg-OH | Endogenous Metabolite , Phosphorylase | |
H-HoArg-OH, a homologue arginine, is a strong inhibitor of human liver and bone alkaline phosphatase. | |||
T6S1292 | Levistolide A | Levistilide A,Diligustilide | Apoptosis , Others |
1. Levistolide A (Diligustilide) inhibits liver fibrosis and angiogenesis. | |||
T3004 | Batilol | Batilolum,Stearyl monoglyceride,Batyl alcohol,1-O-Octadecylglycerol | Others , Endogenous Metabolite |
Batilol (Stearyl monoglyceride), isolated from shark liver oil, is also present in yellow bone marrow of animals and has been described as an inflammatory agent. | |||
TQ0065 | Pseudobufarenogin | ψ-Bufarenogin | Others |
Pseudobufarenogin (ψ-Bufarenogin), a novel anti-tumor compound, suppresses liver cancer growth by inhibiting receptor tyrosine kinase-mediated signaling. | |||
T0361 | Isovaleramide | 3-Methylbutanamide | Dehydrogenase |
Isovaleramide (3-Methylbutanamide) is an anticonvulsant molecule isolated from Valeriana pavonii, which can inhibit the liver alcohol dehydrogenases. | |||
T2925 | Schisandrin B | gamma-Schisandrin,Schizandrin B,Schisandrin B (Sch B),Wuweizisu-B | ATM/ATR , Reactive Oxygen Species , Autophagy |
Schisandrin B (Schisandrin B (Sch B)) has an antioxidant effect on rodent liver and heart. | |||
T2S0342 | Armillarisin A | Others , Interleukin | |
Armillarisin A enhancing the role of macrophages, inhibiting bacteria growth, improving the protein metabolism, and regulating liver function. | |||
TN1143 | 1-O-Acetyl britannilactone | Apoptosis , Antibiotic | |
1-O-Acetyl britannilactone is an agricultural fungicide that induces apoptosis and can be used in studies of liver injury and cancer. | |||
T33817 | Orellanine | 2-(1,3-dihydroxy-4-oxopyridin-2-yl)-1,3-dihydroxypyridin-4-one | Others |
Orellanine is a nephrotoxic compound extracted from the mushroom Cortinarius orellanus. Orellanine strongly inhibits the synthesis of macromolecules (Proteins, RNA and DNA) in Madin-Darby canine kidney cells and in rat l... | |||
TN4661 | Nodosin | IL Receptor , Autophagy | |
Nodosin has anti-inflammatory function of Nodosin via inhibition of IL-2. Nodosin perfusion provides a potential protective effect through inducing HO-1 expression to attenuate ischemia/reperfusion injury in liver transp... | |||
T4586 | (Rac)-Arnebin 1 | beta, beta-dimethylacrylshikonin | Others |
(Rac)-Arnebin 1 (beta, beta-dimethylacrylshikonin) has anti-tumor, anti-inflammatory, anti-immune deficiency and protecting liver. | |||
T7912 | (−)-Myrtenal | (1R)-(−)-Myrtenal | Others |
(−)-Myrtenal ameliorates hyperglycemia by enhancing GLUT2 through Akt in the skeletal muscle and liver of diabetic rats. | |||
T5873 | 2,6-Dihydroxybenzoic acid | Endogenous Metabolite | |
2,6-Dihydroxybenzoic acid, a secondary metabolite derived from salicylic acid, undergoes hydrolyzation by liver enzymes as part of phase I metabolism. | |||
T0281 | Meclocycline sulfosalicylate salt | Meclutin,Mecloderm,Meclan Cream | Antibacterial , Antibiotic |
Meclocycline sulfosalicylate salt (Mecloderm), a tetracycline antibiotic, is used topically (i.e. for skin infections) as it is totally insoluble in water and may damage kidney and liver if given systemically. | |||
T0743 | DL-Carnitine | Carnitina,Carnitine | Others |
DL-Carnitine (Carnitina) is the constituent of liver and striated muscle. In therapeutically It is used to stimulate pancreatic and gastric secretions and to treat hyperlipoproteinemias. | |||
TN1650 | Friedelin | P450 , NOS , Caspase , Prostaglandin Receptor | |
Friedelin possesses antioxidant, gastroprotective, anti-diarrhoeal, liver protective, anti-inflammatory, analgesic and antipyretic activities. | |||
TN1274 | 4-Allylcatechol | 4-Allylpyrocatechol,Hydroxychavicol | Others |
4-Allylcatechol (Hydroxychavicol) has antioxidant activity, it has protective activity against the photosensitization-induced damage to lipids and proteins of rat liver mitochondria, which attributes to its free radical ... | |||
T2744 | Methyl Cholate | Cholic acid methyl ester | Others |
Methyl Cholate (Cholic acid methyl ester) is the methyl form of cholic acid. Cholic acid is a major bile acid produced by the liver and synthesized from cholesterol. | |||
T5S0018 | Betulonic acid | (+)-Betulonic acid,Betunolic acid,Liquidambaric acid | Parasite , HSV |
1. Betulonic acid (Liquidambaric acid) amide stimulated the regenerative response in hepatocytes under conditions of combined toxic exposure and promoted recovery of their qualitative and quantitative characteristics, wh... | |||
TN6925 | Pristane | 2,6,10,14-tetramethylpentadecane | Others |
Pristane (2,6,10,14-tetramethylpentadecane) is a natural product from shark liver oil and a non-antigenic adjuvant. | |||
T0738 | Urea | Ureophil,Carbamide,E-Cardamoni,Carbonyldiamide | Others , DHFR , Wnt/beta-catenin , Arginase , Endogenous Metabolite , Carbonic Anhydrase |
Urea (Carbonyldiamide) is formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end metabolite of protein catabolism and accounts for about one-half of the total urinary solids. | |||
TN1816 | Kadsurin | Antioxidant | |
Kadsurin has anti-oxidant activity, it induces enzymes capable of scavenging oxygen radical species in the liver. Kadsurin may be valuable antitumor promoters or chemopreventors. | |||
T2203 | D-Carnitine hydrochloride | (S)-Carnitine Hydrochloride,L-Carnitine hydrochloride | Others , Endogenous Metabolite |
D-Carnitine hydrochloride ((S)-Carnitine Hydrochloride) is a constituent of striated muscle and liver. It is used therapeutically to stimulate gastric and pancreatic secretions and in the treatment of hyperlipoproteinemi... | |||
T2731 | Usnic Acid | Usniacin | Antibacterial , Autophagy |
Usnic Acid (Usniacin) is an antimicrobial, antitumor and enzyme inhibiting agent shown to uncouple oxidative phosphorylation in mouse-liver mitochondria. Usnic acid induces necrosis in certain cells. | |||
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カタログ番号 | 製品名 | Species | Expression System |
---|---|---|---|
TMPY-02919 | Cadherin 17/CDH17 Protein, Rat, Recombinant (His) | Rat | HEK293 Cells |
Cadherin 17/CDH17 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 86.4 kDa and the accession number is P55281. | |||
TMPY-05352 | Cadherin 17/CDH17 Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 Cells |
Cadherin 17/CDH17 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 111.8 kDa and the accession number is XP_005563762.1. | |||
TMPY-00663 | Alkaline Phosphatase/ALPL Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Alkaline Phosphatase/ALPL Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 55 kDa and the accession number is A0A024RAB4. | |||
TMPY-01912 | Cadherin 17/CDH17 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Cadherin 17/CDH17 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 87 kDa and the accession number is Q12864-1. | |||
TMPJ-01062 | HAMP Protein, Human, Recombinant (GST) | Human | E. coli |
Hepcidin(HAMP)is a secreted protein that belongs to the hepcidin family.It is expressed in liver, heart and brain. It is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron sto... | |||
TMPY-06645 | Cadherin 17/CDH17 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
Cadherin 17/CDH17 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 85.94 kDa and the accession number is XP_005563762.2. | |||
TMPY-01878 | L-FABP Protein, Human, Recombinant (His) | Human | E. coli |
Fatty acid-binding protein, liver, also known as Fatty acid-binding protein 1, Liver-type fatty acid-binding protein, FABP1 and FABPL,is a cytoplasm protein which belongs to thecalycin superfamily and Fatty-acid bindi... | |||
TMPH-02524 | Arginase-1/ARG1 Protein, Mouse, Recombinant (His) | Mouse | P. pastoris (Yeast) |
Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell ... | |||
TMPY-04765 | PKLR Protein, Human, Recombinant (His) | Human | E. coli |
Pyruvate kinase (PKLR) is a critical erythrocyte enzyme that is required for glycolysis and production of ATP. Pyruvate kinase deficiency (PKD) is the most frequent red blood cell enzyme abnormality of the glycolytic pat... | |||
TMPH-02525 | Arginase-1/ARG1 Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli |
Arginase-1/ARG1 Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 50.8 kDa and the accession number is Q61176. | |||
TMPY-00446 | Alkaline Phosphatase/ALPL Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Alkaline Phosphatase/ALPL Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 55 kDa and the accession number is B7XGA6. | |||
TMPY-00594 | Alkaline Phosphatase/ALPL Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
Alkaline Phosphatase/ALPL Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 80.3 kDa and the accession number is B7XGA6. | |||
TMPY-06324 | Cadherin 17/CDH17 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells |
Cadherin 17/CDH17 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 88.24 kDa and the accession number is Q12864-1. | |||
TMPJ-01174 | Cystatin B Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Cystatin B, also called stefin B or liver thiol proteinase inhibitor, is a member of family 1 of the cystatin superfamily. Like Cystatin A, it is an intracellular inhibitor regulating the activities of cysteine proteases... | |||
TMPH-02561 | CES1C Protein, Mouse, Recombinant (GST) | Mouse | E. coli |
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Involved in the extracellular metabolism of lung surfactant. | |||
TMPH-02563 | CES1C Protein, Mouse, Recombinant | Mouse | E. coli |
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Involved in the extracellular metabolism of lung surfactant. CES1C Protein, Mouse, Recombinant is expressed in E. coli expr... | |||
TMPH-02562 | CES1C Protein, Mouse, Recombinant (His & Myc) | Mouse | HEK293 Cells |
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Involved in the extracellular metabolism of lung surfactant. | |||
TMPJ-01020 | GFER Protein, Human, Recombinant (His) | Human | E. coli |
GFER is a hepatotrophic growth factor and flavin-linked sulfhydryl oxidase which belongs to the Erv1/ALR family of proteins. GFER is widely expressed in various human tissues. They are two isoforms of this protein. Isofo... | |||
TMPJ-00583 | CDH17 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Cadherin-17 is a single-pass type I membrane protein that belongs to the cadherin superfamily. Cadherin-17 consists of one extracellular region containing seven cadherin domains and one transmembrane region but it lacks ... | |||
TMPY-00368 | ALR Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Alterations in GFER gene have been associated with progressive mitochondrial myopathy, congenital cataracts, hearing loss, developmental delay, lactic acidosis and respiratory chain deficiency in 3 siblings born to consa... | |||
TMPH-02510 | ANGPTL8 Protein, Mouse, Recombinant (His) | Mouse | P. pastoris (Yeast) |
Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels. May be involved in the metabolic transition between fasting and refeeding: required to direct fatty acids to adipose tissue for storag... | |||
TMPH-02509 | ANGPTL8 Protein, Mouse, Recombinant (E. coli, His) | Mouse | E. coli |
Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels. May be involved in the metabolic transition between fasting and refeeding: required to direct fatty acids to adipose tissue for storag... | |||
TMPH-01091 | CHD1L Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catal... | |||
TMPJ-00932 | PBLD Protein, Human, Recombinant (His) | Human | E. coli |
Phenazine Biosynthesis-Like Domain-Containing protein (PBLD) belongs to the phenazine biosynthesis-like protein (PhzF) family, which is expressed in most tissues. PBLD takes part in the MAPK signaling pathway, and is inv... | |||
TMPJ-00868 | PFKFB1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 is an enzyme that in humans is encoded by the PFKFB1 gene. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate... | |||
TMPJ-00593 | VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His) | Human | HEK293 Cells |
VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 110-140 KDa and the accession number is AAI31823.1. | |||
TMPJ-00414 | VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His & Avi), Biotinylated | Human | HEK293 Cells |
VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-6xHis-Avi tag. The predicted molecular weight is 120-150 KDa and the accession number is P35968. | |||
TMPH-01213 | DNASE1L3 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends. Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA... | |||
TMPH-01214 | DNASE1L3 Protein, Human, Recombinant | Human | E. coli |
Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends. Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA... | |||
TMPH-01212 | DNASE1L3 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends. Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA... | |||
TMPJ-01156 | PHLDA2 Protein, Human, Recombinant (His) | Human | E. coli |
Pleckstrin Homology-Like Domain Family A Member 2 (PHLDA2) is a peripheral membrane protein that belongs to the PHLDA2 family. PHLDA2 is expressed in the placenta and adult prostate gland. In the placenta, it is present ... | |||
TMPJ-00053 | PRL-2 Protein, Human, Recombinant (His) | Human | E. coli |
PTP4A2, also known as PRL2 or PTPCAAX2, is short for Protein tyrosine phosphatase type IVA 2. This protein exists in cell membrane, cytoplasm,endosome and membrane. PTP4A2 is often farnesylated during post-translational ... | |||
TMPJ-00933 | PRDX5 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Peroxisomes are essential organelles that participate in multiple important metabolic processes, including the β-oxidation of fatty acids, plasmalogen synthesis, and the metabolism of reactive oxygen species (ROS). Perox... | |||
TMPJ-00506 | PSG5 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Pregnancy-specific beta-1-glycoprotein 5, is a secreted protein which belongs to the immunoglobulin superfamily, CEA family. It contains 2 Ig-like C2-type (immunoglobulin-like) domains and 1 Ig-like V-type (immunoglobuli... | |||
TMPJ-00018 | CCL16 Protein, Human, Recombinant | Human | E. coli |
CCL16 is a member of CC chemokine family. CCL16 cDNA encodes a 120 amino acid peptide along with a 23 amino acids signal peptide that is cleaved to generate 97 amino acid protein. CCL16 is distantly related to other CC c... | |||
TMPY-02956 | Apolipoprotein L/APOL1 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
APOL1, also known as apolipoprotein L1, is a minor apoprotein component of HDL (High-density lipoprotein) or 'good cholesterol' which is synthesized in the liver and also in many other tissues, including pancreas, kidney... | |||
TMPJ-00235 | TPO Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Thrombopoietin (TPO) is a glycoprotein hormone which belongs to the EPO/TPO family. It produced by the liver and kidney which regulates the production of platelets. TPO stimulates the production and differentiation of me... | |||
TMPK-00114 | C-Reactive Protein /CRP Protein, Human, Recombinant (His) | Human | HEK293 Cells |
C-reactive protein (CRP) is a polypeptide molecule belonging to the family of pentraxins. CRP is synthesized primarily by the liver in response to certain pro-inflammatory cytokines. It plays an important role in innate ... | |||
TMPJ-00842 | FGF-2 Protein, Rat, Recombinant | Rat | E. coli |
FGF-basic is a members of the Fibroblast Growth Factors (FGFs) family. The family constitutes a large family of proteins involved in many aspects of development including cell proliferation, growth, and differentiation. ... | |||
TMPY-03274 | CXCL11 Protein, Human, Recombinant | Human | E. coli |
I-TAC, also known as CXCL11, is a small cytokine belonging to the CXC chemokine family. It is highly expressed in peripheral blood leukocytes, pancreas and liver, with moderate levels in thymus, spleen and lung and low e... | |||
TMPJ-00261 | TGF beta 2 Protein, Mouse/Rat, Recombinant | Mouse,Rat | HEK293 Cells |
Transforming growth factor beta 2 (TGF-β2) is a member of TGF-beta superfamily that shares a characteristic cysteine knot structure. Mice with TGF-β2 gene deletion show defects in development of cardiac, lung, craniofaci... | |||
TMPY-03118 | ORM2 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
ORM2 belongs to the calycin superfamily, lipocalin family. Lipocalins share limited regions of sequence homology and a common tertiary structure architecture. They transport small hydrophobic molecules such as steroids, ... | |||
TMPY-03221 | Intrinsic Factor Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Gastric intrinsic factor, also known as GIF, belongs to the of the cobalamin transport protein family. It is a glycoprotein produced by the parietal cells of the stomach. Gastric intrinsic factor plays a key role in the ... | |||
TMPJ-00662 | RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli) | Human | E. coli |
CD254, also known as RANKL, TNFSF11, TRANCE, OPGL and ODF, is a type II membrane protein of the tumor necrosis factor (TNF) superfamily, and affects the immune system and control bone regeneration and remodeling. RANKL i... | |||
TMPY-05004 | FGF-4 Protein, Human, Recombinant | Human | E. coli |
FGF (fibroblast growth factor) signalling is known to be required for many aspects of mesoderm formation and patterning during Xenopus development and has been implicated in regulating genes required for the specificati... | |||
TMPY-02481 | ACOX1 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
Peroxisomal acyl-coenzyme A oxidase 1(ACOX1 or AOX) is the first enzyme of the fatty acid beta-oxidation pathway and belongs to the Acyl-CoA oxidase family. Human liver peroxisomes contain two acyl-CoA oxidases, namely, ... | |||
TMPJ-01467 | Oncostatin M/OSM Protein, Human, Recombinant (E. coli, His) | Human | E. coli |
Oncostatin M (OSM) is a glycoprotein belonging to the interleukin-6 family of cytokines that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. OSM encodes a growth regulator, ... | |||
TMPY-02707 | PAH Protein, Human, Recombinant (415 Asn/Asp, His) | Human | Baculovirus Insect Cells |
PAH (phenylalanine hydroxylase), also known as PH, belongs to the biopterin-dependent aromatic amino acid hydroxylase family. It contains 1 ACT domain, N-terminal region of PAH is thought to contain allosteric binding si... | |||
TMPJ-00071 | EPO/Erythropoietin Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Erythropoietin (EPO) is a glycoprotein hormone that is principally known for its role in erythropoiesis, where it is responsible for stimulating proliferation and differentiation of erythroid progenitor cells. Erythropoi... | |||
TMPY-01085 | VLDLR Protein, Human, Recombinant (His) | Human | HEK293 Cells |
The very low density lipoprotein receptor, known as VLDLR, is a single-pass type 1 integral membrance protein and a member of the LDL receptor family. This receptor family includes LDL receptor, LRP, megalin, VLDLR and A... | |||
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