| T5256 |
All-trans-retinal
|
All trans-Retinal,Retinaldehyde,Vitamin A aldehyde |
Others
,
Endogenous Metabolite
|
|
All-trans-retinal (Vitamin A aldehyde) is a one of the major vitamin A metabolites in the retina. All-trans-RAL is regenerated to the visual chromophore, 11-cis-retinal in physiological conditions. |
| T7408 |
all-trans-4-Oxoretinoic acid
|
all-trans 4-Keto Retinoic Acid |
Endogenous Metabolite
|
|
all-trans-4-Oxoretinoic acid (all-trans 4-Keto Retinoic Acid) is an active metabolite of vitamin A. |
| T7600 |
Fucoxanthin
|
all-trans-Fucoxanthin |
Others
|
|
Fucoxanthin (all-trans-Fucoxanthin) is a carotenoid that occurs naturally in certain algae. It is found as an accessory pigment in the chloroplasts of brown algae and most other heterokonts, giving them a brown or olive-... |
| T35953 |
all-trans-Anhydro Retinol
|
|
|
|
All-trans-Anhydro Retinol (Anhydrovitamin A) is a Vitamin A metabolite commonly employed in the synthesis of multivitamin preparations[1]. |
| T5852 |
Canthaxanthin
|
all-trans-Canthaxanthin,E 161g |
Reactive Oxygen Species
|
|
Canthaxanthin (E 161g) is a red-orange carotenoid that belongs to the xanthophyll group. This naturally occurring pigment is present in bacteria, algae and some fungi. |
| TMS2180 |
Zeaxanthin
|
Anchovyxanthin,All-Trans-Zeaxanthin |
Antioxidant
,
Endogenous Metabolite
|
|
1. Lutein and Zeaxanthin (All-Trans-Zeaxanthin) in neural tissue may have biological effects that include antioxidation, anti-inflammation, and structural actions. 2. Lutein and Zeaxanthin may be protective against eye d... |
| T1183 |
Retinol
|
all-trans-Retinol,Vitamin A,Vitamin A1,Alphalin |
Others
|
|
Retinol (Alphalin) and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune r... |
| T1051 |
Retinoic acid
|
Vitamin A acid,ATRA,all-trans-Retinoic acid,Tretinoin |
Retinoid Receptor
,
Endogenous Metabolite
,
PPAR
,
Autophagy
|
|
Retinoic acid (Tretinoin), a metabolite of vitamin A, is a natural agonist of the retinoic acid receptor RAR and inhibits RARα/β/γ (IC50=14 nM). Retinoic acid induces cellular differentiation, reduces cellular proliferat... |
| T4749 |
Squalene
|
Nikko Squalane EX,Super Squalene,AddaVax,all-trans-Squalene,trans-Squalene,Spinacene |
Reactive Oxygen Species
,
Endogenous Metabolite
,
Antifungal
|
|
Squalene (AddaVax) is a natural organic compound originally obtained for commercial purposes primarily from shark liver oil, though there are botanical sources as well, including rice bran, wheat germ, and olives. All hi... |
| TQ0262 |
Dihomo-γ-linolenic acid
|
Diroleuton,all-cis-8,11,14-Eicosatrienoic acid,Ro 12-1989 |
Others
|
|
Ro 12-1989 can be converted into prostaglandin E1 (PGE1). Ro 12-1989 competes with arachidonic acid for COX and lipoxygenase, inhibiting the production of arachidonic acid's eicosanoids. |
| T83660 |
3(Z),6(Z),9(Z),12(Z),15(Z)-Octadecapentaenoic Acid
|
C18:5 n-3,C18:5(3Z,6Z,9Z,12Z,15Z),all-cis-3,6,9,12,15-Octadecapentaenoic Acid |
|
|
3(Z),6(Z),9(Z),12(Z),15(Z)-Octadecapentaenoic acid, a microalgal polyunsaturated fatty acid (PUFA), is identified in G. kowalevskii and serves as a chemotaxonomic biomarker for microalgae and dinoflagellates. |
| T0877 |
Gallic acid
|
3,4,5-Trihydroxybenzoic acid,Gallate,Benzoic acid |
Apoptosis
,
Ferroptosis
,
Reactive Oxygen Species
,
ROS
,
COX
,
Endogenous Metabolite
|
|
Gallic acid (Benzoic acid) is found in almost all plants. Plants known for their high gallic acid content include gallnuts,grapes,tea,hops and oak bark. |
| T2732 |
(-)-Epicatechin gallate
|
(−)-Epicatechin 3-gallate,Epicatechin gallate,(-)-Epicatechin 3-gallate,(-)-Epicatechin 3-O-gallate,ECG |
Virus Protease
,
COX
,
Autophagy
|
|
(-)-Epicatechin gallate ((-)-Epicatechin 3-O-gallate) is one of the catechin isomers and a potent antioxidant that can modulate a wide range of membrane proteins. Its bilayer-modifying potency was tested using gramicidin... |
| T5219 |
L-Alloisoleucine
|
L-allo-Isoleucine,(3R)-LS-Isoleucine,L(+)-Alloisoleucine |
Others
,
Endogenous Metabolite
|
|
L-Alloisoleucine (L-allo-Isoleucine) is a branched chain amino acid and is a stereoisomer of L-isoleucine. It is a common constituent of human plasma (albeit at low levels). L-alloisoleucine is produced as a byproduct of... |
| T3040 |
Gallein
|
Pyrogallolphthalein,Mordant violet 25,Alizarin violet |
Others
|
|
Gallein (Mordant violet 25) is a small molecule inhibitor of Gβγ activity. |
| TN6600 |
Kaempferol 3-O-(6''-galloyl)-beta-D-glucopyranoside
|
|
HIV Protease
|
|
Kaempferol 3-O-(6''-galloyl)-beta-D-glucopyranoside is a glucopyranoside that inhibits HIV-2 RNase H with an IC50 of 5.19 μM. |
| TN1160 |
1,2,3,6-Tetragalloylglucose
|
1,2,3,6-Tetra-O-galloyl-β-D-glucose,TeGG |
LDL
,
UGT
|
|
1,2,3,6-Tetragalloylglucose (TeGG) has antioxidative activity, it also shows the most potent anticomplement activity (IC50 = 34 microM). 1,2,3,6-Tetragalloylglucose is also a potent inhibitor of UDP glucuronosyltransfera... |
| TN1608 |
(-)-Epigallocatechin-3-(3''-O-methyl) gallate
|
(-)-EGCG-3''-O-ME |
Antioxidant
,
Antibacterial
|
|
(-)-Epigallocatechin-3-(3''-O-methyl) gallate ((-)-EGCG-3''-O-ME) is a natural product isolated from tea leaves with strong antioxidant, cytotoxic and antibacterial activity, which enhances the adhesive stability of etch... |
| T6S1010 |
Allomatrine
|
|
Others
|
|
Allomatrine is a natural product from Sophora alopecuroides L. Allomatrine, when given i.c.v., may stimulate the descending dynorphinergic neuron, resulting in the stimulation of KORs in the spinal cord. |
| T4S0554 |
Theaflavine-3,3'-digallate
|
TFBG,theaflavin digallate |
Others
|
|
1. Theaflavine-3,3'-digallate (theaflavin digallate) and lactic acid together could reduce herpes simplex virus transmission. |
| TN1370 |
Allura Red AC
|
Allura Red,CI 16035,FD&C RED NO. 40 |
Others
,
Estrogen/progestogen Receptor
,
Androgen Receptor
|
|
Allura Red AC (CI 16035) is a very important food azo dye used in the food, pharmaceutical, paper, cosmetic and textile industries.Allura Red AC promotes susceptibility to experimental colitis via mouse intestinal seroto... |
| T5076 |
L-Allothreonine
|
L-allo-Threonine |
Others
,
Endogenous Metabolite
|
|
L-Allothreonine (L-allo-Threonine) is an essential amino acid in humans. L-Allothreonine is abundant in human plasma, particularly in newborns. Severe deficiency of threonine causes neurological dysfunction and lameness ... |
| T3845 |
(+)-Gallocatechin
|
Gallocatechol,D-Gallocatechin |
Others
|
|
(+)-Gallocatechin (Gallocatechol) possesses free radical scavenging ability. (+)-Gallocatechin has moderate affinity to the human cannabinoid receptor. |
| T3123 |
Allicin
|
|
ERK
,
IL Receptor
,
Others
,
IκB/IKK
,
p38 MAPK
,
TNF
,
ROS
,
Caspase
,
Antifection
|
|
Allicin exerts antioxidant, bactericidal, anti-cancer, anti-inflammatory activities, it exerts an inhibitory immunomodulatory effect on intestinal epithelial cells. Allicin could significantly inhibit vascular smooth mus... |
| T5581 |
6-(γ,γ-Dimethylallylamino)purine
|
N6-(2-lsopentenyl)adenine,Triacanthine |
Others
|
|
6-(γ,γ-Dimethylallylamino)purine (Triacanthine), which is a plant growth substance, shows hypertensive and antitumor activity, also cardiotonic, antispasmodic and a respiratory analeptic. |
| T2987 |
(-)-Epigallocatechin
|
l-Epigallocatechin,Epigallocatechin,EGC |
MMP
,
Autophagy
|
|
(-)-Epigallocatechin, the predominant flavonoid in green tea, possesses the unique ability to attach to unfolded native polypeptides, thereby inhibiting their transformation into amyloid fibrils. |
| T3729 |
Ethyl gallate
|
Nipagallin A,Phyllemblin,gallic acid ethyl ester |
MMP
,
NF-κB
,
Akt
,
Antibacterial
|
|
Ethyl gallate (gallic acid ethyl ester) obviously decreases cell proliferation in MDA-MB-231 and MCF-7 cells in a dose- and time-dependent manner, exhibits cytotoxicity in a dose-dependent manner. Ethyl gallate can inhib... |
| T3S1866 |
Propyl gallate
|
Tenox PG,n-Propyl gallate,Gallic acid propyl esterZ |
Antioxidant
|
|
Propyl gallate (Gallic acid propyl esterZ) is an antioxidant used in foods especially animal fats and vegetable oils, also in a wide variety of cosmetics and beauty care products. |
| T5579 |
Allyl Methyl Sulfide
|
|
Endogenous Metabolite
,
Antibacterial
|
|
Allyl Methyl Sulfide is a bioactive organosulfur compound found in garlic with antibacterial, antioxidant, and anticancer activities. |
| T19189 |
Allocholic acid
|
|
Others
|
|
Allocholic acid is a fetal bile acid found in vertebrates and reappears during liver regeneration and carcinogenesis. It is also a potent and specific stimulant of the adult olfactory system. |
| T5429 |
Theaflavin 3,3'-digallate
|
8-Gingerol,TFDG |
Virus Protease
,
Antioxidant
,
HIV Protease
,
HSV
|
|
Theaflavin 3,3'-digallate (8-Gingerol) , a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancer chemopreventive actions, it reduces tumor angiogenesis by downregul... |
| TN1006 |
Tirucallol
|
|
NOS
,
NO Synthase
,
Prostaglandin Receptor
|
|
Tirucallol is an antiinflammatory agent isolated from Euphorbia lactea.Tirucallol exerts a topical anti-inflammatory effect in vivo, via a mechanism of action related to the neutrophil migration. |
| T3807 |
(-)-Gallocatechin gallate
|
(-)-gallocatechin-3-O-gallate,(-)-Gallocatechol gallate,Gallocatechin gallate |
Others
|
|
(-)-Gallocatechin gallate ((-)-gallocatechin-3-O-gallate) is the polyphenol isolated from tea, with cancer-preventive activities. (-)-Gallocatechin gallate decreases osteoclastogenesis at 20 microM. |
| T8185 |
(+)-Viroallosecurinine
|
Viroallosecurinine |
Antibacterial
|
|
(+)-Viroallosecurinine (Viroallosecurinine) is a natural alkaloid with antibacterial activity. It exhibits a MIC of 0.48 μg/mL for Ps. Aeruginosa and Staph. aureus. |
| T5800 |
Allosecurinine
|
Allosecurinin |
Antifungal
|
|
Allosecurinine has Antifungal Activity. |
| T2S1682 |
Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside
|
Pinocembrin 7-O-(3''-galloyl-4'',6''-(S)-hexahydroxydiphenoyl)-beta-D-glucose,pinocembrin-7-o-3-o-galloyl-4-6-hexahydroxydiphenoyl-beta-d-glucoside |
Amylase
|
|
Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside can moderately inhibit α-amylase activity, with the IC50 value of 0.03 umol/ml. |
| T0925 |
Allantoin
|
Glyoxyldiureide,5-Ureidohydantoin |
Endogenous Metabolite
,
Imidazoline Receptor
|
|
Allantoin (Glyoxyldiureide), a urea hydantoin found in urine and plants, is used in dermatological preparations. |
| T6S0920 |
2"-O-Galloylhyperin
|
2''-O-Galloylhyperin,Q-100605,FT-0689359 |
Others
|
|
2"-O-Galloylhyperin (FT-0689359) found in Pyrola. It increases ruminal fiber fermentability by formed wall-bound lignin in primary maize cell walls. |
| T3756 |
Allitol
|
Allodulcit,Allodulcitol,d-allitol |
Others
|
|
Allitol (d-allitol) is a substrate for the production of L-form ketoses and aldoses. |
| TN1576 |
Diallyl disulfide
|
|
IL Receptor
,
NOS
,
NF-κB
|
|
Diallyl disulfide has antitumor effect, the effect can be enhanced by miR-200b and miR-22. |
| TN1369 |
Alloimperatorin
|
Prangenidin |
Others
|
|
Alloimperatorin (Prangenidin) exhibits in vitro antitumor activity in HL-60 acute myeloid leukemia cancer cells via inducing apoptosis, cell cycle disruption and inhibition of cell migration. It photosensitizes efficient... |
| T3828 |
(-)-Gallocatechin
|
(2S,3R)-gallocatechin,(−)-GC |
Others
|
|
(-)-Gallocatechin ((−)-GC) has free radical scavenging ability and moderate affinity to the human cannabinoid receptor. |
| T7972 |
Gallic aldehyde
|
|
HSV
|
|
Gallic aldehyde shows potent antiviral activity against HSV-1. |
| T3A2467 |
Allocryptopine
|
Thalictrimine,Fagarine I |
Potassium Channel
|
|
Allocryptopine (Thalictrimine) induces muscle contraction and relaxation in urinary bladder and ileum, respectively. |
| T2772 |
S-allyl-L-cysteine
|
S-Allylcysteine |
Apoptosis
,
Others
|
|
S-allyl-L-cysteine (S-Allylcysteine), a natural constituent of fresh garlic, has antioxidant and anticancer properties in animals. |
| TN1274 |
4-Allylcatechol
|
4-Allylpyrocatechol,Hydroxychavicol |
Others
|
|
4-Allylcatechol (Hydroxychavicol) has antioxidant activity, it has protective activity against the photosensitization-induced damage to lipids and proteins of rat liver mitochondria, which attributes to its free radical ... |
| T3749 |
Pyrogallol
|
Piral,1,2,3-trihydroxybenzene |
Apoptosis
,
Others
,
Endogenous Metabolite
,
Antifungal
|
|
Pyrogallol (Piral) is a white crystalline powder and a powerful reducing agent prepared by heating gallic acid. |
| T16685 |
Purpurogallin
|
|
Xanthine Oxidase
|
|
Purpurogallin is a naturally phenol extracted from the plants of Quercus spp. It has effective xanthine oxidase inhibitory activity (IC50: 0.2 µM). Purpurogallin also has antioxidant and anti-inflammatory effects. |
| TN1525 |
Convallatoxin
|
|
NF-κB
,
P-gp
,
PPAR
|
|
Convallatoxin is a natural product |
| T13539 |
Allopurinol riboside
|
|
Others
,
Endogenous Metabolite
,
Parasite
,
Drug Metabolite
|
|
Allopurinol riboside is a metabolite of allopurinol and shows effective activities against parasites. |
