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カタログ番号	製品名	別名	ターゲット
T60564	PI3K/Akt/mTOR-IN-2		Apoptosis , Akt , PI3K , mTOR
	PI3K/Akt/mTOR-IN-2 is a potent PI3K/AKT/mTOR inhibitor.PI3K/Akt/mTOR-IN-2 has anticancer effects and is selective for MDA-MB-231 cells with an IC50 of 2.29 μM.PI3K/Akt/mTOR-IN-2 exhibits anticancer activity and induces c...		Apoptosis , Akt , PI3K , mTOR
T71272	PI3K/Akt-IN-C89
	PI3K/Akt-IN-C89 is a novel Inhibitor of the PI3K-Akt Pathway, Inducing Autophagy of Female Germline Stem Cells.
T9393	(E)-Akt inhibitor-IV	(E)-AKTIV,CS-1992	Akt
	(E)-Akt inhibitor-IV ((E)-AKTIV) ((E)-AKTIV) is an inhibitor of PI3K-Akt.		Akt
T62997	PI3K/AKT-IN-1
	PI3K/AKT-IN-1 is a potent, dual PI3K/AKT inhibitor that acts on PI3Kγ (IC50: 6.99 μM), PI3Kδ (IC50: 4.01 μM) and AKT (IC50: 3.36 μM). PI3K/AKT-IN-1 induces caspase 3-dependent apoptosis by inhibiting the PI3K/AKT pathway...
T2423	P7C3-A20		Others
	P7C3-A20 is a derivative of P7C3 that has proneurogenic and neuroprotective activity.		Others
T72880	PI3K/AKT-IN-2
	PI3K/AKT-IN-2, a dual inhibitor of PI3K and AKT, prevents the epithelial-mesenchymal transition (EMT) and promotes apoptosis. Additionally, it impedes tubulin polymerization.
T7953	BpV(HOpic)	bpV (HOpic)	PTEN
	BpV(HOpic) (bpV (HOpic)) is a potent inhibitor of PTEN (IC50 of 14 nM).		PTEN
T13862	Recilisib	Ex-RAD,ON 01210	Akt , PI3K
	Recilisib (ON 01210) is a radioprotectant,can activate AKT, PI3K activities in cells.		Akt , PI3K
T63455	PI3K/Akt/mTOR-IN-3
	PI3K/Akt/mTOR-IN-3 is a potent inhibitor of PI3K/Akt/mTOR. PI3K/Akt/mTOR-IN-3 inhibits the migration of MCF-7 cells (IC50: 0.77 μM), HeLa cells (IC50: 1.23 μM) and HepG2 cells (IC50: 4.57 μM). PI3K/Akt/mTOR-IN-3 inhibite...
T72227	PI3K/Akt/CREB activator 1
	PI3K/Akt/CREB Activator 1 is a potent, orally active compound that acts as an activator for the PI3K/Akt/CREB pathway. It enhances neuronal proliferation, induces differentiation of Neuro-2a cells into neuron-like morpho...
T13376	YS-49		RAAS , Akt , PI3K , Adrenergic Receptor
	YS-49 is an activator of PI3K/Akt (a downstream target of RhoA).		RAAS , Akt , PI3K , Adrenergic Receptor
TP1197	Sincalide	SQ19844,CCK-8,Cholecystokinin octapeptide	Others
	Sincalide (CCK-8) is a cholecystokinetic drug administered by injection to aid in diagnosing disorders of the gallbladder and pancreas. It is the 8-amino acid C-terminal fragment of cholecystokinin.		Others
T7879	TASP0415914		Akt , PI3K
	TASP0415914 is an orally potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ). T		Akt , PI3K
T1921	Alpelisib	BYL-719	PI3K
	Alpelisib (BYL-719) is a PI3Kα inhibitor (IC50=5 nM) with selective, potent, and oral activity. Alpelisib inhibits PI3Kβ/γ/δ with low activity (IC50=250/290/1200 nM). Alpelisib has antitumor activity and is targeted to P...		PI3K
T6322	Copanlisib	BAY 80-6946	Apoptosis , PI3K
	Copanlisib (BAY 80-6946) is a phosphoinositide 3-kinase (PI3K) inhibitor with potential antineoplastic activity. Copanlisib inhibits the activation of the PI3K signaling pathway, which may result in inhibition of tumor c...		Apoptosis , PI3K
T0365	Thioridazine hydrochloride	Mellaril,Aldazine	Apoptosis , Potassium Channel , Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , Antibacterial , Autophagy
	Thioridazine hydrochloride (Mellaril) , an antipsychotic drug, is used in the therapy of psychosis and schizophrenia and shows serotonin antagonism or D4 selectivity.
T14998	Copanlisib dihydrochloride	BAY 80-6946 dihydrochloride	Apoptosis , PI3K , mTOR
	Copanlisib dihydrochloride (BAY 80-6946 dihydrochloride) is an ATP-competitive pan-class I PI3K inhibitor (IC50s: 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ). Copanlisib dihydrochloride has super...		Apoptosis , PI3K , mTOR
T1967	AZD-3463	ALK/IGF1R inhibitor	Apoptosis , IGF-1R , ALK , Autophagy
	AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.		Apoptosis , IGF-1R , ALK , Autophagy
T1101	Minocycline hydrochloride	Minocycline HCl	HIF/HIF Prolyl-Hydroxylase , Antibacterial , Antibiotic
	Minocycline hydrochloride (Minocycline HCl) is a tetracycline antibiotic with excellent absorption and tissue penetration that is used for several bacterial infections as well as treatment of acne. Minocycline hydrochlor...		HIF/HIF Prolyl-Hydroxylase , Antibacterial , Antibiotic
T3705	GDC0084	GDC-0084,RG7666,GDC 0084	PI3K , mTOR
	GDC0084 (RG7666) is a PI3K inhibitor with potential antineoplastic activity. GDC0084 (RG7666) specifically inhibits PI3K in the PI3K/AKT kinase (or protein kinase B) signaling pathway, thereby inhibiting the activation o...		PI3K , mTOR
T1826	PI3K-IN-1	Voxtalisib Analogue,Voxtalisib (SAR245409, XL765) Analogue,XL765,SAR245409	DNA-PK , PI3K
	PI3K-IN-1 (Voxtalisib Analogue) is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR.		DNA-PK , PI3K
T2078	Fimepinostat	CUDC-907,PI3K/HDAC Inhibitor,CUDC 907	Apoptosis , PI3K , HDAC
	Fimepinostat (CUDC 907) is an orally bioavailable inhibitor of both phosphoinositide 3-kinase (PI3K) class I and pan-histone deacetylase (HDAC) enzymes, with potential antineoplastic activity. Upon oral administration, C...		Apoptosis , PI3K , HDAC
T37379	Protectin D1	Neuroprotectin D1,NPD1	Akt , PI3K
	Protectin D1 (Neuroprotectin D1) is a neuroprotectin produced by neuronal cells and is a potential cardioprotective agent.Protectin D1 attenuates myocardial ischemia/reperfusion injury and inhibits imiquimod-induced psor...		Akt , PI3K
T12777	RTC-5	TRC-382	EGFR
	RTC-5 (TRC-382) is a phenothiazine compound that has been specifically enhanced for its potent anti-cancer properties. It exhibits considerable effectiveness against an EGFR-driven cancer xenograft model. The mechanism ...		EGFR
T7832	Ibrolipim	NO-1886	LPL Receptor
	Ibrolipim (NO-1886) attenuates high glucose-induced endothelial dysfunction in cultured human umbilical vein endothelial cells via PI3K/Akt pathway.		LPL Receptor
T15300	Fluorofenidone	AKF-PD	Others
	Fluorofenidone (AKF-PD) attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and extracellular matrix (ECM) deposition via the PI3K/Akt signalling pathway. Fluorofenidone is an an...		Others
T67965	Torbafylline		cAMP , PI3K , PDE
	Torbafylline, a xanthine derivative, is a phosphodiesterase (PDE) inhibitor that attenuates burn-induced protein hydrolysis in rat skeletal muscle through activation of the PDE4/cAMP/EPAC/PI3K/Akt pathway, and inhibits t...		cAMP , PI3K , PDE
T83658	SQLE-IN-1		Antifungal
	SQLE-IN-1 is a squalene epoxidase (SQLE) inhibitor with anti-tumor activity. It can inhibit the proliferation and migration of liver cancer cell line Huh7, inhibit the production of cellular cholesterol, and increase the...		Antifungal
T3467	Miransertib	ARQ-092,AKT inhibitor 2	Akt , Parasite
	Miransertib (ARQ-092) is an orally bioavailable, selective, and potent allosteric Akt inhibitor.		Akt , Parasite
T14214	AMG 511		PI3K
	AMG 511 is a potent and orally available pan inhibitor of class I PI3Ks(Kis of 4 nM, 6 nM, 2 nM and 1 nM for PI3Kα, β, δ and γ, respectively). It exhibits anti-tumor activity in mouse glioblastoma xenograft model[1]. AMG...		PI3K
T6070	(E/Z)-Rigosertib sodium	(E/Z) ON-01910 sodium	PLK
	ON-01910 is a non-ATP-competitive PLK1 inhibitor(IC50 of 9 nM, in a cell-free assay). It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Rigosertib inhibits PI3K/Akt pathway and activates oxidativ...		PLK
T5485	OSU-T315	OSU-T315 (1,5-regioisomer),ILK-IN-2	Apoptosis , Integrin , Autophagy
	OSU-T315 (OSU-T315 (1,5-regioisomer)) (1,5-regioisomer) is a ILK inhibitor.		Apoptosis , Integrin , Autophagy
T5092	AIM-100	AIM100	ACK
	AIM-100 is a Ack1 inhibitor (IC50: 24 nM).		ACK
T16750	Rigosertib	ON-01910	Apoptosis , FLT , PLK , PI3K , Bcr-Abl , CDK , PDGFR , Src
	Rigosertib (ON-01910) is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM). Rigosertib is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition of the PI3 kina...		Apoptosis , FLT , PLK , PI3K , Bcr-Abl , CDK , PDGFR , Src
T16923	SPP-86		c-RET
	SPP-86 is an effective and selective cell-permeable inhibitor of RET tyrosine kinase with an IC50 of 8 nM.		c-RET
T6334	Ridaforolimus	AP23573,Deforolimus,MK-8669	mTOR , Autophagy
	Ridaforolimus (AP23573) is a small molecule and non-prodrug analogue of the lipophilic macrolide antibiotic rapamycin with potential antitumor activity. Ridaforolimus binds to and inhibits the mammalian target of rapamyc...		mTOR , Autophagy
T5818	Rigosertib sodium	Rigosertib,Estybon,ON-01910	Apoptosis , PLK , PI3K
	Rigosertib sodium (ON-01910), a non-ATP-competitive inhibitor of PLK1(IC50=9 nM), exhibits 30-fold higher specificity activity over Plk2 and no effect on Plk3.		Apoptosis , PLK , PI3K
T4325	COTI-2	COTI 2,COTI2	Apoptosis , p53
	COTI-2, an orally available thiosemicarbazone, is an activator of mutant forms of the p53 protein with potential antineoplastic activity.		Apoptosis , p53
T24715	RLX	THA-Q,PD-139530,THA Q,PD 139530,PD139530
	RLX is a PI3K/Akt/FoxO3a signaling inhibitor in experimental colon cancer.
T63957	PI3K-IN-29
	PI3K-IN-29, a potent inhibitor of PI3K, exhibits substantial inhibition capabilities against U87MG, HeLa, and HL60 cells, with IC50 values of 0.264, 2.04, and 1.14 µM, respectively. It effectively blocks the PI3K/Akt sig...
T71188	LY2780301
	LY2780301 is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor LY2780301 binds to and inhibits the activity of Akt, which...
T34778	Talaumidin
	Talaumidin is a natural neurotrophic agent which promotes neurite outgrowth from neurons through the PI3K/Akt pathway.
T29165	XC-302 free base	XC 302,Puquitinib,XC-302,XC302
	XC-302 is a multi-targeted inhibitor, it induces autophagy of nasopharyngeal cancer cells via inhibiting the PI3K/AKT/mTOR signaling pathway.
T24573	Ovatodiolide
	Ovatodiolide is a broad anticancer agent that acts by upregulating hsa-miR-155, suppressing the BCR-ABL fusion gene, and dysregulating the PI3K/AKT/mTOR pathway.
T64219	PI3K/mTOR Inhibitor-6
	PI3K/mTOR Inhibitor-6 (Compound 19c) is a potent dual PI3K/mTOR inhibitor that is more stable than gedatolisib in artificial gastric fluid. 10 μM of PI3K/mTOR Inhibitor-6 significantly inhibits the PI3K/Akt/mTOR signalli...
T13376L	YS-49 monohydrate (132836-42-1 free base)	YS-49 monohydrate	Others
	YS-49 (monohydrate) is an activator of PI3K/Akt (a downstream target of RhoA).		Others
T70152	Miransertib mesylate
	Miransertib mesylate is a selective AKT inhibitor that binds to and inhibits the activity of AKT in a non-ATP competitive manner, which may result in the inhibition of the PI3K/AKT signaling pathway. This may result in r...
T39929	MS21
	MS21 is a unique AKT degrader that selectively hampers the proliferation of cancers with mutations in the PI3K/PTEN pathway, alongside wild-type KRAS and BRAF.
T64041	PI3K/mTOR Inhibitor-7
	PI3K/mTOR Inhibitor-7 is a potent dual PI3K/mTOR inhibitor. PI3K/mTOR Inhibitor-7 is 4.7-fold more potent than gedatolisib, with IC50 values of 1.4 μM and 0.3 μM, respectively. 10 μM of PI3K/mTOR Inhibitor-7 is able to s...
T63211	AKT-IN-10
	AKT-IN-10 is a potent AKT inhibitor that has shown research potential in breast and prostate cancers. Among them is protein kinase B (PKB, also known as AKT), which is central to PI3K/AKT/mTOR signaling in cells and whos...

Compounds

PI3K/Akt/mTOR-IN-2

T60564

Synonym:

Target: Apoptosis, Akt, PI3K, mTOR

(E)-Akt inhibitor-IV

T9393

Synonym: (E)-AKTIV,CS-1992

Synonym: Ex-RAD,ON 01210

PI3K/Akt/CREB activator 1

Target: RAAS, Akt, PI3K, Adrenergic Receptor

Sincalide

TP1197

Synonym: SQ19844,CCK-8,Cholecystokinin octapeptide

Target: Apoptosis, PI3K

Thioridazine hydrochloride

T0365

Synonym: Mellaril,Aldazine

Target: Apoptosis, Potassium Channel, Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, Antibacterial, Autophagy

Copanlisib dihydrochloride

T14998

Synonym: BAY 80-6946 dihydrochloride

Target: Apoptosis, PI3K, mTOR

AZD-3463

T1967

Synonym: ALK/IGF1R inhibitor

Target: Apoptosis, IGF-1R, ALK, Autophagy

Minocycline hydrochloride

T1101

Synonym: Minocycline HCl

Target: HIF/HIF Prolyl-Hydroxylase, Antibacterial, Antibiotic

GDC0084

T3705

Synonym: GDC-0084,RG7666,GDC 0084

Target: PI3K, mTOR

PI3K-IN-1

T1826

Synonym: Voxtalisib Analogue,Voxtalisib (SAR245409, XL765) Analogue,XL765,SAR245409

Target: DNA-PK, PI3K

Fimepinostat

T2078

Synonym: CUDC-907,PI3K/HDAC Inhibitor,CUDC 907

Target: Apoptosis, PI3K, HDAC

Protectin D1

T37379

Synonym: Neuroprotectin D1,NPD1

Target: cAMP, PI3K, PDE

Synonym: ARQ-092,AKT inhibitor 2

Target: Akt, Parasite

(E/Z)-Rigosertib sodium

T6070

Synonym: (E/Z) ON-01910 sodium

Target: PLK

OSU-T315

T5485

Synonym: OSU-T315 (1,5-regioisomer),ILK-IN-2

Target: Apoptosis, Integrin, Autophagy

Target: Apoptosis, FLT, PLK, PI3K, Bcr-Abl, CDK, PDGFR, Src

Synonym: AP23573,Deforolimus,MK-8669

Target: mTOR, Autophagy

Rigosertib sodium

T5818

Synonym: Rigosertib,Estybon,ON-01910

Target: Apoptosis, PLK, PI3K

COTI-2

T4325

Synonym: COTI 2,COTI2

Target: Apoptosis, p53

RLX

T24715

Synonym: THA-Q,PD-139530,THA Q,PD 139530,PD139530

Synonym: XC 302,Puquitinib,XC-302,XC302

PI3K/mTOR Inhibitor-6

T64219

Synonym:

Target:

YS-49 monohydrate (132836-42-1 free base)

T13376L

Synonym: YS-49 monohydrate

PI3K/mTOR Inhibitor-7

カタログ番号	製品名	別名	ターゲット
T5654	Musk ketone		Others
	Musk ketone can induce the growth repression and the apoptosis of cancer cells. Musk ketone increases activity of glutathione S-transferase and thus may prove to be useful cancer chemoprotectant.		Others
TN1891	Lupiwighteone		Apoptosis , BCL , PARP , Caspase
	Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells.		Apoptosis , BCL , PARP , Caspase
TN1079	Deoxyelephantopin		NF-κB
	Deoxyelephantopin has anti-inflammatory, hepatoprotective, and wound healing activities; it also has antitumor activity.Deoxyelephantopin inhibits NF-κB, MAPK, PI3K/Akt, and β-catenin signaling		NF-κB
T6677	Sophocarpine		ERK , p38 MAPK , NF-κB , TLR , COX , HER , JNK , STAT
	Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.		ERK , p38 MAPK , NF-κB , TLR , COX , HER , JNK , STAT
TN1644	Flavanomarein		Others
	Flavanomarein demonstrates potent antioxidative property, including free radical scavenging activity, inhibition of lipid peroxidation, as well as lipid-lowering effects in human HepG2 hepatocellular carcinoma cells trea...		Others
T5S1982	Periplocin	Periplocoside	Apoptosis , Others
	1. Periplocin (Periplocoside) has anti-cancer effects on lung cancer cells, induces apoptosis and inhibits growth of cancer cells by the beta-catenin/Tcf signaling pathway. 2. Periplocin is used for treatment of rheumato...		Apoptosis , Others
TL0006	Cichoric Acid	Dicaffeoyltartaric acid,Chicoric Acid	Reactive Oxygen Species , HIV Protease
	Cichoric Acid (Dicaffeoyltartaric acid) is a potent inhibitor of human immunodeficiency virus type-1 (HIV-1) integrase and the replication in tissues. It also a class of cannabinomimetics with CB2 receptor-dependent and ...		Reactive Oxygen Species , HIV Protease
T2791	Pectolinarin		Apoptosis , Others , NO Synthase , Prostaglandin Receptor , Interleukin
	Pectolinarin is a Cirsium isolate with anti-inflammatory activity.
T2798	Esculetin	Aesculetin,Cichorigenin	Lipoxygenase , Akt , PI3K
	Esculetin (Cichorigenin) is a coumarin derivative from various natural plant products with various biological and pharmaceutical properties including anti-edema, anti-inflammatory and anti-tumour effects. It inhibits lip...		Lipoxygenase , Akt , PI3K
T2746	Sophocarpine monohydrate	Sophocarpine	Apoptosis , Influenza Virus , Akt , PI3K , AMPK , Autophagy
	Sophocarpine monohydrate, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
TN4761	Phellamurin		P-gp
	Phellamurin inhibits intestinal P-glycoprotein in a dose-dependent manner, there is a serious interaction occurred between Phellamurin with cyclosporin, to ensure the efficacy of cyclosporin, we suggest that the coadmini...		P-gp
TN1405	Arnicolide D		Akt , Caspase , PI3K , STAT , mTOR
	Arnicolide D is a sesquiterpene lactone. Arnicolide D isolates from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling path...		Akt , Caspase , PI3K , STAT , mTOR
T4S0498	Glaucocalyxin A	Wangzaozin B,Leukamenin F	Apoptosis , Akt , Caspase , PI3K
	1. Glaucocalyxin A (Leukamenin F)-SBE-β-CD could be useful with a better solubility and sustained function in drug delivery. 2. Glaucocalyxin A activates caspase-3, decreases BAD phosphorylation, and reduces the expressi...		Apoptosis , Akt , Caspase , PI3K
T3826	Polygalasaponin F		NF-κB , TLR , Akt , PI3K
	Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and reduce the expression of inducible nitric oxide synthases. Po...		NF-κB , TLR , Akt , PI3K
T5740	25(R,S)-Ruscogenin	(25RS)-Ruscogenin	Others , HIF
	25(R,S)-Ruscogenin is a natual product.		Others , HIF
T8160	EGCG Octaacetate		Others , Antibacterial
	EGCG Octaacetate, a prodrug of EGCG, is utilized to enhance the stability and bioavailability of EGCG in vivo. It has high efficacy, bioavailability, anti-oxidation, and anti-angiogenesis capacities.		Others , Antibacterial
T2P2806	Hederacolchiside A1	Raddeanoside R13	Apoptosis , ERK , MEK , Akt , PI3K , Parasite , mTOR
	Hederacolchiside A1 (Raddeanoside R13) shows anti-leishmanial activity, it exhibits a strong antiproliferative activity on all stages of development of the parasite by altering membrane integrity and potential. Hederacol...		Apoptosis , ERK , MEK , Akt , PI3K , Parasite , mTOR
TN3500	Beta-Amyrone	β-Amyron	COX , AChR , PPAR , Antifection
	beta-Amyrone (β-Amyron) has antifungal activity against Chikungunya virus replication with an EC50 of 86 uM. beta-Amyrone has anti-inflammatory activity through inhibiting the expression of COX-2. beta-Amyrone exhibits a...		COX , AChR , PPAR , Antifection
T3P2904	α-Linolenic acid	Alpha-Linolenic Acid,Linolenic acid	Akt , PI3K
	α-Linolenic acid (Alpha-Linolenic Acid) is an essential fatty acid belonging to the omega-3 fatty acids group. It is highly concentrated in certain plant oils and has been reported to inhibit the synthesis of prostagland...		Akt , PI3K
T2163	Dihydrocapsaicin	CCRIS1589,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide	Others , TRP/TRPV Channel
	Dihydrocapsaicin (CCRIS1589) is isolated from Capsicum fruit. Capsaicin is the primary active component of the heat and pain-eliciting lipid soluble fraction of the Capsicum pepper. Like capsaicin, dihydrocapsaicin is an...		Others , TRP/TRPV Channel
T5736	1,3-Dicaffeoylquinic acid	CYNARIN,Cyclohexanecarboxylic acid, 1,3-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-4,5-dihydroxy-, (1S,3R,4R,5R)-,1,3-O-Dicaffeoylquinic acid,1,5-Dicaffeoylquinic acid	Reactive Oxygen Species , Akt , PI3K
	1,3-Dicaffeoylquinic acid (CYNARIN) is a natural product. It shows antioxidant and choleretic properties and is a potential immunosuppressive agent.		Reactive Oxygen Species , Akt , PI3K
T6817	Deguelin	(-)-Deguelin,(-)-cis-Deguelin	Apoptosis , Akt , PI3K , Autophagy
	Deguelin ((-)-Deguelin) is a PI3K/AKT Inhibitor, which is a natural product isolated from plants in the Mundulea sericea family.		Apoptosis , Akt , PI3K , Autophagy
TN1507	Clematichinenoside AR		TNF , Autophagy
	Clematichinenoside AR exerts anti-inflammatory and immunosuppressive properties, it has anti-arthritic effects on PI3K/Akt signaling pathway and TNF-α± associated with collagen-induced arthritis.		TNF , Autophagy
TN1346	Oxypalmatine	8-Oxypalmatine	Apoptosis
	Oxypalmatine (8-Oxypalmatine) is a berberine-type alkaloid isolated from Phellodendron amurense that regulates breast cancer cell proliferation and apoptosis by inhibiting PI3K/AKT signaling and its efficacy in breast ca...		Apoptosis
T6S1844	Tenacissoside H	Tenacissimoside C	Others
	Tenacissoside H (Tenacissimoside C) has antitumor activity on esophageal cancer through arresting cell cycle and regulating PI3K/Akt-NF-κB transduction cascade.		Others
T3890	Verbenalin	Verbenalol β-D-glucopyranoside,Verbenaloside,Verbenalol glucoside,Cornin	Others
	Verbenalin (Verbenaloside) induces angiogenesis via a programmed PI3K/Akt/eNOS/VEGF signaling axis.		Others
T2S0410	Euphorbia factor L1	Euphorbiasteroid	Apoptosis , P-gp
	Euphorbia factor L1 (Euphorbiasteroid) can reduce Bcl-2, PI3K, AKT, and mTOR protein and mRNA levels, and up-regulate caspase-9 and caspase-3 protein levels. It induces autophagy and has anti-cancer, anti-adipogenic, ant...		Apoptosis , P-gp
T11685	Isolongifolene	(-)-Isolongifolene	Apoptosis , Others
	Isolongifolene ((-)-Isolongifolene), a tricyclic sesquiterpene isolated from Murraya koenigii, exhibits antioxidant, anti-inflammatory, anticancer, and neuroprotective properties. It mitigates Rotenone-induced oxidative ...		Apoptosis , Others
T16324	Nimbolide		Apoptosis , NF-κB , CDK
	Nimbolide suppresses CDK4/CDK6 kinase activity. Nimbolide inhibits the NF-κB, Wnt, PI3K-Akt, MAPK, and JAK-STAT signaling pathways. Nimbolide causes apoptosis through the inactivation of NF-κB. Nimbolide is a triterpene ...		Apoptosis , NF-κB , CDK
T4S1796	Heterophyllin B		PI3K
	Heterophyllin B effectively suppresses the adhesion and invasion of the human esophageal carcinoma cells by mediating the PI3K/AKT/β-catenin pathways and regulating the expression levels of adhesion- and invasion-associa...		PI3K
T3385	Gypenoside XVII	GP-17,Gynosaponin S	Estrogen Receptor/ERR , GSK-3 , Endogenous Metabolite
	Gypenoside XVII (Gynosaponin S) confers protection against Aβ25-35-induced neurotoxicity through estrogen receptor-dependent activation of PI3K/Akt pathways, activation of Nrf2/ARE/HO-1 and inactivation of GSK-3β pathway...		Estrogen Receptor/ERR , GSK-3 , Endogenous Metabolite
TN2091	Polygalacin D		Apoptosis , IAP
	Polygalacin D shows anti- proliferation, anti-inflammary, and hepatoprotective activities, it can inhibit the expression of lipopolysaccharide (LPS)-induced iNOS and COX-2 protein and mRNA without an appreciable cytotoxi...		Apoptosis , IAP
T5S1331	Herbacetin		c-Met/HGFR , Akt
	1. Herbacetin induces apoptosis in HepG2 cells, by ROS and PI3K/Akt pathway. 2. Herbacetin suppresses the HGF-induced motility of human breast cancer MDA-MB-231 cells by inhibiting c-Met and Akt phosphorylation.		c-Met/HGFR , Akt
T3330	Trans-Trimethoxyresveratrol	trans-trismethoxy Resveratrol,E-Resveratrol Trimethyl Ether,MR-3,Tri-O-methylresveratrol,3,4',5-Trimethoxy-trans-stilbene,Trimethoxystilbene	Reactive Oxygen Species
	trans-Trimethoxyresveratrol (MR-3), a natural methoxylated analog of resveratrol, inhibits breast Y cell invasiveness by downregulation of PI3K/Akt and Wnt/β-catenin signaling cascades and reversal of epithelial-mesenchy...		Reactive Oxygen Species
TL0008	Gigantol		Wnt/beta-catenin , Glucosidase
	Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β-catenin in breast cancer cells. Gigantol may be developed as a...		Wnt/beta-catenin , Glucosidase
T2S2382	3'-Hydroxypterostilbene	3'-HPT	Apoptosis , Autophagy
	3'-Hydroxypterostilbene (3'-HPT), a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells with IC50s of 9.0, 40.2, and 70.9 μM for COLO 205, HCT-116, and HT-29 cells, respectively, b...		Apoptosis , Autophagy
TN1461	(-)-Butin	Butin	Akt , PI3K , Nrf2
	(-)-Butin (Butin) has antioxidant activity, can protect cells against H2O2-induced apoptosis, oxidative DNA damage and oxidative mitochondrial dysfunction; it attenuates oxidative stress by activating Nrf2-mediated Mn SO...		Akt , PI3K , Nrf2
T4672	Brevilin A		Apoptosis , Anti-infection , JAK , STAT , Autophagy
	Brevilin A is a sesquiterpene lactone isolated from Centipeda minima, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells with anti-tumor activity. Brevilin A is a selective inhibitor of JAK-STAT si...		Apoptosis , Anti-infection , JAK , STAT , Autophagy
T5S0896	Loureirin A		Akt , PI3K
	Loureirin A has an inhibitory effect on platelet activation, perhaps through an impairment of PI3K/Akt signaling.Loureirin A negatively affects agonist-induced platelet aggregation such as collagen, collagen-related pept...		Akt , PI3K
TN1013	Cucurbitacin D		Apoptosis
	Cucurbitacin D, a triterpenoid isolated from Ecballium elaterium (L.), exhibits anticancer and antitumor activity, inhibits glucose uptake and lactate production in metastatic PrC, and induces inflammasome activation ind...		Apoptosis
T4S1545	Licarin B	(-)-Licarin B,Licarine B	transporter , Antibacterial , PPAR
	1.(-)-Licarin B (Licarine B) has anti-mycobacterial activity.		transporter , Antibacterial , PPAR
T3752	4-Hydroxybenzyl alcohol	4-Methylolphenol,P-Methylolphenol	Apoptosis , Endogenous Metabolite
	4-Hydroxybenzyl alcohol (P-Methylolphenol) exhibits beneficial effects in cerebral ischemic injury, has neuroprotective effect through upregulation of Nrf2, Prdx6, and PDI expression via the PI3K/Akt pathway. 4-Hydroxybe...		Apoptosis , Endogenous Metabolite
TN1557	Decursinol angelate		ERK , VEGFR , PKC , JNK
	Decursinol angelate has anti-tumor, anti-inflammatory, anti-oxidant, and hepatoprotective activities, it inhibits VEGF-induced angiogenesis via suppression of the VEGFR-2-signaling pathway; it also suppresses invasion an...		ERK , VEGFR , PKC , JNK
T6S0653	Linarin	Buddleoflavonoloside,Buddleoside,Acacetin-7-O-rutinoside,Acaciin,Linarine	TNF , AChE
	1. Linarin (Acacetin-7-O-rutinoside) (acacetin-7-O-β-d-rutinoside) shows selective dose dependent inhibitory effect on acetylcholinesterase. 2. Linarin alleviates GalN/LPS-induced liver injury by suppressing TNF-α-mediat...		TNF , AChE
T3729	Ethyl gallate	Nipagallin A,Phyllemblin,gallic acid ethyl ester	MMP , NF-κB , Akt , Antibacterial
	Ethyl gallate (gallic acid ethyl ester) obviously decreases cell proliferation in MDA-MB-231 and MCF-7 cells in a dose- and time-dependent manner, exhibits cytotoxicity in a dose-dependent manner. Ethyl gallate can inhib...		MMP , NF-κB , Akt , Antibacterial
T2808	Bilobalide	(-)-Bilobalide	Apoptosis , Endogenous Metabolite , Autophagy
	Bilobalide ((-)-Bilobalide), a bioactive from Gingko Biloba, is active on hypoxia-induced alterations.		Apoptosis , Endogenous Metabolite , Autophagy
T3780	Oroxin B	Hypocretin-2	Apoptosis , PTEN , Antioxidant , PI3K , Autophagy
	Oroxin B (Hypocretin-2) has antioxidant activity.		Apoptosis , PTEN , Antioxidant , PI3K , Autophagy
T2966	Beta-Sitosterol	Cupreol,Beta-Sitosterol,β-Sitosterol,Azuprostat,SKF 14463,22,23-Dihydrostigmasterol,Betaprost	Apoptosis , Lipase , Endogenous Metabolite
	Beta-Sitosterol (SKF 14463) has recently been shown to induce G2/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways. Beta-Sitosterol (SKF 14463) , a main dietary phytosterol foun...		Apoptosis , Lipase , Endogenous Metabolite
T3923	Calycosin	Cyclosin,3'-Hydroxyformononetin	Apoptosis , Tyrosinase
	Calycosin (Cyclosin) acts as a selective estrogen receptor modulator. Calycosin induces apoptosis in human ovarian cancer SKOV3 cells by activating caspases and Bcl-2 family proteins. Calycosin suppresses breast cancer c...		Apoptosis , Tyrosinase
TN2063	Physalin B	NSC-287088	Apoptosis , NF-κB , Akt , PI3K , Nrf2 , NOD
	Physalin B is one of the major active compounds from the Solanaceae family of plants and has a wide range of biological activities for the treatment of inflammatory eczema and herpes, among other diseases.Physalin B amel...		Apoptosis , NF-κB , Akt , PI3K , Nrf2 , NOD
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天然物製品

Target: Apoptosis, BCL, PARP, Caspase

Target: ERK, p38 MAPK, NF-κB, TLR, COX, HER, JNK, STAT

Synonym: Periplocoside

Target: Apoptosis, Others

Cichoric Acid

TL0006

Synonym: Dicaffeoyltartaric acid,Chicoric Acid

Target: Reactive Oxygen Species, HIV Protease

Pectolinarin

T2791

Synonym:

Target: Apoptosis, Others, NO Synthase, Prostaglandin Receptor, Interleukin

Esculetin

T2798

Synonym: Aesculetin,Cichorigenin

Target: Lipoxygenase, Akt, PI3K

Sophocarpine monohydrate

T2746

Synonym: Sophocarpine

Target: Apoptosis, Influenza Virus, Akt, PI3K, AMPK, Autophagy

Target: Akt, Caspase, PI3K, STAT, mTOR

Glaucocalyxin A

T4S0498

Synonym: Wangzaozin B,Leukamenin F

Target: Apoptosis, Akt, Caspase, PI3K

Polygalasaponin F

T3826

Synonym:

Target: NF-κB, TLR, Akt, PI3K

25(R,S)-Ruscogenin

T5740

Synonym: (25RS)-Ruscogenin

Target: Others, Antibacterial

Hederacolchiside A1

T2P2806

Synonym: Raddeanoside R13

Target: Apoptosis, ERK, MEK, Akt, PI3K, Parasite, mTOR

beta-Amyrone

TN3500

Synonym: β-Amyron

Target: COX, AChR, PPAR, Antifection

α-Linolenic acid

T3P2904

Synonym: Alpha-Linolenic Acid,Linolenic acid

Target: Akt, PI3K

Dihydrocapsaicin

T2163

Synonym: CCRIS1589,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide

Target: Others, TRP/TRPV Channel

1,3-Dicaffeoylquinic acid

T5736

Synonym: CYNARIN,Cyclohexanecarboxylic acid, 1,3-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-4,5-dihydroxy-, (1S,3R,4R,5R)-,1,3-O-Dicaffeoylquinic acid,1,5-Dicaffeoylquinic acid

Target: Reactive Oxygen Species, Akt, PI3K

Deguelin

T6817

Synonym: (-)-Deguelin,(-)-cis-Deguelin

Target: Apoptosis, Akt, PI3K, Autophagy

Clematichinenoside AR

TN1507

Synonym:

Target: TNF, Autophagy

Oxypalmatine

TN1346

Synonym: 8-Oxypalmatine

Target: Apoptosis

Tenacissoside H

T6S1844

Synonym: Tenacissimoside C

Target: Others

Verbenalin

T3890

Synonym: Verbenalol β-D-glucopyranoside,Verbenaloside,Verbenalol glucoside,Cornin

Target: Others

Euphorbia factor L1

T2S0410

Synonym: Euphorbiasteroid

Target: Apoptosis, P-gp

Isolongifolene

T11685

Synonym: (-)-Isolongifolene

Target: Apoptosis, Others

Nimbolide

T16324

Synonym:

Target: Apoptosis, NF-κB, CDK

Synonym: GP-17,Gynosaponin S

Target: Estrogen Receptor/ERR, GSK-3, Endogenous Metabolite

Polygalacin D

TN2091

Synonym:

Target: Apoptosis, IAP

Herbacetin

T5S1331

Synonym:

Target: c-Met/HGFR, Akt

trans-Trimethoxyresveratrol

T3330

Synonym: trans-trismethoxy Resveratrol,E-Resveratrol Trimethyl Ether,MR-3,Tri-O-methylresveratrol,3,4',5-Trimethoxy-trans-stilbene,Trimethoxystilbene

Target: Reactive Oxygen Species

Gigantol

TL0008

Synonym:

Target: Wnt/beta-catenin, Glucosidase

3'-Hydroxypterostilbene

T2S2382

Synonym: 3'-HPT

Target: Apoptosis, Autophagy

(-)-Butin

TN1461

Synonym: Butin

Target: Akt, PI3K, Nrf2

Brevilin A

T4672

Synonym:

Target: Apoptosis, Anti-infection, JAK, STAT, Autophagy

Synonym: (-)-Licarin B,Licarine B

Target: transporter, Antibacterial, PPAR

4-Hydroxybenzyl alcohol

T3752

Synonym: 4-Methylolphenol,P-Methylolphenol

Target: Apoptosis, Endogenous Metabolite

Decursinol angelate

TN1557

Synonym:

Target: ERK, VEGFR, PKC, JNK

Linarin

T6S0653

Synonym: Buddleoflavonoloside,Buddleoside,Acacetin-7-O-rutinoside,Acaciin,Linarine

Target: TNF, AChE

Ethyl gallate

T3729

Synonym: Nipagallin A,Phyllemblin,gallic acid ethyl ester

Target: MMP, NF-κB, Akt, Antibacterial

Bilobalide

T2808

Synonym: (-)-Bilobalide

Target: Apoptosis, Endogenous Metabolite, Autophagy

Oroxin B

T3780

Synonym: Hypocretin-2

Target: Apoptosis, PTEN, Antioxidant, PI3K, Autophagy

Beta-Sitosterol

T2966

Synonym: Cupreol,Beta-Sitosterol,β-Sitosterol,Azuprostat,SKF 14463,22,23-Dihydrostigmasterol,Betaprost

Target: Apoptosis, Lipase, Endogenous Metabolite

Calycosin

T3923

Synonym: Cyclosin,3'-Hydroxyformononetin

Target: Apoptosis, Tyrosinase

Physalin B

TN2063

Synonym: NSC-287088

Target: Apoptosis, NF-κB, Akt, PI3K, Nrf2, NOD

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Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPJ-00059	IL-7 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL7 can associate with the hepatocyte growth factor (HGF) to form a hybrid cytokine that functions...
TMPH-01348	FSHR Protein, Human, Recombinant (His)	Human	HEK293 Cells
	G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. FSHR Protein, Human, Recombinant (His) is expresse...
TMPH-03365	REG3A Protein, Rat, Recombinant (E.coli, His)	Rat	E. coli
	Bactericidal C-type lectin. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway. REG3A Protein, Rat, Recombinant (E.coli, His) is expressed in E. ...
TMPH-01347	FSHR Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. FSHR Protein, Human, Recombinant (E. coli, His) is...
TMPK-01034	SEMA4B Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Semaphorin 4B (SEMA4B) inhibits the invasion of non-small cell lung cancer (NSCLC) through PI3K-dependent suppression of MMP9 activation. SEMA4B may induce FoxO1 nuclear retention through suppressing PI3K/Akt signaling p...
TMPK-00136	ULBP-2 Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, E...
TMPH-02019	REG3A Protein, Human, Recombinant (GST)	Human	E. coli
	Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Regulates keratinocyte proliferation a...
TMPJ-00181	PD-1 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell pr...
TMPY-05250	CLEC3A Protein, Mouse, Recombinant (His)	Mouse	Baculovirus Insect Cells
	C-type lectin domain family 3 member A (CLEC3A) is a poorly characterized protein belonging to the superfamily of C-type lectins. Elevated CLEC3A expression may correlate with breast IDC metastatic potential and indicate...
TMPY-03795	EIF5A2 Protein, Human, Recombinant (His)	Human	E. coli
	Eukaryotic translation initiation factor 5A2 (EIF5A2) has been demonstrated to be upregulated in numerous types of human cancer and is associated with cancer progression. Silencing of EIF5A2 in the NSCLC cells resulted i...

IL-7 Protein, Human, Recombinant (His)

TMPJ-00059

Species: Human

Expression System: HEK293 Cells

FSHR Protein, Human, Recombinant (His)

TMPH-01348

Species: Human

Expression System: HEK293 Cells

REG3A Protein, Rat, Recombinant (E.coli, His)

TMPH-03365

Species: Rat

Expression System: E. coli

FSHR Protein, Human, Recombinant (E. coli, His)

TMPH-01347

Species: Human

Expression System: E. coli

SEMA4B Protein, Mouse, Recombinant (His)

TMPK-01034

Species: Mouse

Expression System: HEK293 Cells

ULBP-2 Protein, Human, Recombinant (His & Avi)

TMPK-00136

Species: Human

Expression System: HEK293 Cells

REG3A Protein, Human, Recombinant (GST)

TMPH-02019

Species: Human

Expression System: E. coli

PD-1 Protein, Human, Recombinant (His & Avi), Biotinylated

TMPJ-00181

Species: Human

Expression System: HEK293 Cells

CLEC3A Protein, Mouse, Recombinant (His)

TMPY-05250

Species: Mouse

Expression System: Baculovirus Insect Cells

EIF5A2 Protein, Human, Recombinant (His)

TMPY-03795

Species: Human

Expression System: E. coli

カタログ番号	製品名
L1300	PI3K-AKT-mTOR Compound Library	420 compounds
	A unique collection of 420 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved with PI3K/Akt/mTOR signaling;
L2195	Anti-Prostate Cancer Compound Library	2070 compounds
	2070 compounds associated with prostate cancer that can be used for high-throughput and high-content screening.
L2193	Anti-Liver Cancer Compound Library	1787 compounds
	1787 species of compounds related to liver cancer that can be used in anti-liver cancer drug development and pharmacological studies.
L8500	HIF-1 Signaling Pathway Compound Library	1336 compounds
	A unique collection of 1336 HIF-1 related small chemicals can be used for drug discovery in ischemic disease and cancer and related mechanism studies；

ライブラリー

PI3K-AKT-mTOR Compound Library

L1300

Compounds: 420

Anti-Prostate Cancer Compound Library

L2195

Compounds: 2070

Anti-Liver Cancer Compound Library

L2193

Compounds: 1787

HIF-1 Signaling Pathway Compound Library

L8500

Compounds: 1336