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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T6335 | Tie2 kinase inhibitor 1 | Tie2 kinase inhibitor | Tie-2 |
Tie2 kinase inhibitor 1 (Tie2 kinase inhibitor), an optimized compound of SB-203580, is selective to Tie2 with IC50 of 0.25 μM, which is 200-fold more effective than p38. | |||
T5524 | Aurora kinase inhibitor-3 | Aurora Kinase Inhibitor III | Aurora Kinase |
Aurora kinase inhibitor-3 (Aurora Kinase Inhibitor III) is a potent inhibitor of Aurora A kinase (IC50 = 42 nM).1 It is selective for Aurora A over BMX, BTK, IGF-1R, c-Src, TRKB, SYK, and EGFR. | |||
T4191 | Multi-kinase inhibitor 1 | Multi-kinase inhibitor I | Others , Bcr-Abl , PDGFR , c-Kit |
Multi-kinase inhibitor 1 (Multi-kinase inhibitor I) is a Multi-kinase inhibitor. | |||
T9040 | Aurora kinase inhibitor-2 | IUN-70219,Aurora Kinase Inhibitor II | Aurora Kinase |
Aurora kinase inhibitor-2 (IUN-70219) is a cell-permeable anilinoquinazoline that inhibit the activity of Aurora A (IC50 = 0.39 M). | |||
T10276L | AKT Kinase Inhibitor HCl | AKT Kinase Inhibitor HCl(842148-40-7 Free base) | Akt |
AKT Kinase Inhibitor HCl is an Akt inhibitor with antitumor activity. | |||
T11184 | EML4-ALK kinase inhibitor 1 | EML4 ALK kinase inhibitor 1,EML4-ALK kinase inhibitor 1 | ALK |
EML4-ALK kinase inhibitor 1 (EML4 ALK kinase inhibitor 1) is a potent oral active inhibitor of echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK), with an IC50 of 1 nM. | |||
T60108 | PDGFR Tyrosine Kinase Inhibitor III | PDGF Receptor Tyrosine Kinase Inhibitor III | PDGFR |
PDGFR Tyrosine Kinase Inhibitor III (PDGF Receptor Tyrosine Kinase Inhibitor III) (PDGF Receptor Tyrosine Kinase Inhibitor III) is a multikinase inhibitor that inhibits PDGFR, EGFR, FGFR, PKA, and PKC, respectively. PDGF... | |||
T16987 | TAO Kinase inhibitor 1 | Others , MAPK | |
TAO Kinase inhibitor 1 delays mitosis and induces mitotic cell death. TAO Kinase inhibitor 1 is a selective and ATP-competitive thousand-and-one amino acid kinases inhibitor (IC50s: 11 to 15 nM for TAOK1 and 2, respectiv... | |||
T12728 | RIP2 Kinase Inhibitor 3 | Others , RIP kinase | |
RIP2 Kinase Inhibitor 3 is a potent and selective inhibitor of RIP2 with an IC50 of 1 nM. | |||
T12721 | Rho-Kinase-IN-1 | ROCK | |
Rho-Kinase-IN-1 is an inhibitor of ROCK with Kis of 30.5 nM and 3.9 nM for ROCK1 and ROCK2, respectively. Rho-Kinase-IN-1 can be used in studies about excessive cell proliferation, remodeling, edema and inflammation dise... | |||
T8864 | Thymidylate Kinase Inhibitor, YMU1 | Others | |
YMU1 is a human thymidylate kinase (hTMPK) inhibitor. YMU1 stabilizes the conformation of ligand-induced degradation (LID) region of hTMPK and blocks the catalytic site or ATP-binding site. | |||
T4692 | Protein kinase inhibitors 1 hydrochlorid | Protein kinase inhibitors 1 hydrochlorid (1365986-44-2(free base)) | Others |
Protein kinase inhibitors 1 hydrochlorid (Protein kinase inhibitors 1 hydrochlorid (1365986-44-2(free base))) is a novel inhibitor of HIPK2 with an IC50 of 74 nM and Kd of 9.5 nM. | |||
TP1053L | Protein Kinase C 19-31 acetate | Protein Kinase C 19-31 acetate(121545-65-1 free base),PKC (19-31) acetate | PKC |
Protein Kinase C 19-31 acetate, a peptide inhibitor of protein kinase C (PKC), derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31) with a serine at position 25 replacing the wild-type alanine, is... | |||
T10276 | AKT Kinase Inhibitor | Akt | |
T9564 | IRE1α kinase-IN-1 | IRE1 | |
IRE1α kinase-IN-1 is a highly selective IRE1α (ERN1) inhibitor, with an IC50 of 77 nM. It displays 100-fold selectivity for IRE1α over the IRE1β isoform. It inhibits ER stress-induced IRE1α oligomerization and autophosph... | |||
T10687 | Casein Kinase II Inhibitor IV | Casein Kinase | |
T64350 | Casein kinase 1δ-IN-3 | Casein Kinase | |
Casein kinase 1δ-IN-3 (Casein kinase 1δ-IN-3) (Compound 23a) is a casein kinase 1 delta (CK1d) inhibitor with a pIC50 of 6.5376 M. | |||
TP1051L | Protein Kinase C Peptide Substrate acetate | Protein Kinase C Peptide Substrate acetate(120253-69-2 free base) | Others |
Protein Kinase C Peptide Substrate acetate targets specific cell spacers ina manner that is dependent on second messengers and specific adaptor proteins in response to extracellular signals that activate g protein-couple... | |||
T5466 | Tyrosine kinase-IN-1 | VEGFR , FGFR , FLT , PDGFR | |
Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor(KDR, Flt-1, FGFR1 and PDGFRα with IC50s of 4nM, 20nM, 4nM, 2 nM ,respectively) | |||
T6409 | ALK kinase inhibitor-1 | SAR348830 | Others |
SAR348830 is an ALK inhibitor, targeting anaplastic lymphoma kinase. | |||
T77500 | Casein kinase 1δ-IN-6 | Casein Kinase | |
Casein kinase 1δ-IN-6 is a potent and selective inhibitor of the protein kinase CK-1δ with an IC50 of 23 nM.Casein kinase 1δ-IN-6 shows neuroprotective and anti-inflammatory activity in both in vitro and in vivo assays.C... | |||
T64376 | Casein kinase 1δ-IN-9 | NADPH | |
Casein kinase 1δ-IN-9 is a Quinone reductase 2 inhibitor with IC50 of 0.6μM. | |||
T67755 | Protein kinase G inhibitor-1 | PKA | |
Protein kinase G inhibitor-1 is a potent Protein kinase G inhibitor, IC50= 0.9 uM. | |||
TP1271L | Calmodulin-Dependent Protein Kinase II 290-309 acetate | Calmodulin-Dependent Protein Kinase II 290-309 acetate (115044-69-4 Free base) | CaMK |
Calmodulin-Dependent Protein Kinase II 290-309 acetate is an effective antagonist of Ca2+/calmodulin-dependent protein kinase II (IC50 = 52 nM). | |||
T9175 | Casein Kinase inhibitor A51 | Apoptosis , Casein Kinase | |
Casein Kinase inhibitor A51 is an orally active casein kinase 1α (CK1α) inhibitor with anticancer activity that induces apoptosis in leukemia cells, and may be used in the study of neck cancers, acute myeloid leukemia, b... | |||
T9631 | IRAK-4 protein kinase inhibitor 2 | IRAK | |
IRAK-4 protein kinase inhibitor 2 is a potent interleukin-1 receptor-associated kinase-4 (IRAK-4) inhibitor(IC50 = 4 μM). | |||
T9779 | Protein kinase inhibitor 6 | ||
Protein kinase inhibitor 6 is a protein kinase inhibitor. | |||
T9940 | Protein kinase G inhibitor-2 | Others | |
Protein kinase G inhibitor-2 exhibits antibacterial, antiviral, and antitumor activities. | |||
T77501 | TAO Kinase inhibitor 2 | Serine/threonin kinase | |
TAO Kinase inhibitor 2 is a TAO kinase inhibitor with an IC50 of 50-500 nM. TAO Kinase inhibitor 2 inhibits KIAA1361 and JIK with IC50s of 50-500 nM. | |||
T9229 | Pim-1/2 kinase inhibitor 1 | Pim | |
Pim-1/2 Kinase Inhibitor 1, an orally active inhibitor, impedes the action of Pim kinases by preventing their ability to phosphorylate peptides. It particularly inhibits the phosphorylation of 4E-BP1 and p27 Kip1 by Pim ... | |||
T60295 | Casein kinase 1δ-IN-1 | WAY-643895 | Casein Kinase |
Casein kinase 1δ-IN-1 (WAY-643895) is an inhibitor of casein kinase 1δ (CK1δ), which inhibits CK1δ. Casein kinase 1δ-IN-1 can be used in the study of neurodegenerative diseases such as Alzheimer's disease. | |||
TP1216 | CaM kinase II inhibitor TFA salt | Autocamtide-2-related inhibitory peptide (TFA) | CaMK |
CaM kinase II inhibitor TFA salt (Autocamtide-2-related inhibitory peptide (TFA)) is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM. | |||
T77648 | Casein kinase 1δ-IN-14 | WAY-637081 | Others |
Casein kinase 1δ-IN-14 (WAY-637081) can be used to study atherosclerosis-related cardiovascular disease. | |||
T77746 | Tyrosine kinase-IN-7 | EGFR , Antiviral | |
Tyrosine kinase-IN-7 is a potent inhibitor of the tyrosine kinase EGFR, inhibiting EGFR(WT) and EGFR(T790M) and showing anti-cancer and anti-tumor activity in a variety of cancer cell lines. Tyrosine kinase-IN-7 has pote... | |||
T4026 | SU5408 | VEGFR2 Kinase Inhibitor I | VEGFR |
SU5408 (VEGFR2 Kinase Inhibitor I) is a potent, cell-permeable inhibitor of the VEGFR2 kinase. | |||
T77708 | Casein kinase 1δ-IN-7 | Casein Kinase | |
Casein kinase 1δ-IN-7 is a Casein kinase 1δ inhibitor for neurodegenerative diseases such as Alzheimer's disease. | |||
T83627 | Pim-1 kinase inhibitor 8 | Pim , PKC | |
Pim-1 kinase inhibitor 8 is a potent Pim-1 kinase inhibitor with anticancer activity and can effectively inhibit cell migration.Pim-1 kinase inhibitor 8 is cytotoxic to MCF-7 and HepG2 cells, and is a candidate compound ... | |||
T60109 | Protein kinase inhibitor H-7 | 5-(2-methylpiperazine-1-sulfonyl)isoquinoline,1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine | PKC |
Protein kinase inhibitor H-7 (5-(2-methylpiperazine-1-sulfonyl)isoquinoline) is a potent inhibitor of protein kinase C (PKC) with a Ki of 6 μM. Protein kinase inhibitor H-7 is also a cyclic nucleotide dependent protein k... | |||
T77709 | Casein kinase 1δ-IN-8 | Casein Kinase | |
Casein kinase 1δ-IN-8 is an inhibitor of casein kinase 1δ and is used to treat neurodegenerative diseases such as Alzheimer's disease type. | |||
T67944 | P38 MAP Kinase Inhibitor Ⅵ | p38 MAPK | |
p38 MAP Kinase Inhibitor Ⅵ is a potent p38 MAP Kinase inhibitor with anti-inflammatory activity. | |||
T82174 | HRIO2 kinase ligand-1 | Others | |
hRIO2 kinase ligand-1 is a potent ligand for hRIO2 kinase (Kd: 520 nM). | |||
T38841 | IRE1α kinase-IN-2 | IRE1α kinase-IN-2 | |
IRE1α kinase-IN-2 is a highly potent inhibitor of IRE1α kinase, demonstrating an EC50 of 0.82 μM. It effectively impedes IRE1α kinase autophosphorylation with an IC50 of 3.12 μM. Additionally, IRE1α kinase-IN-2 effective... | |||
T40336 | IRE1α kinase-IN-6 | IRE1α kinase-IN-6 | |
IRE1α kinase-IN-6 is a potent IRE1α inhibitor with an IC 50 value of 4.4 nM. | |||
T22831 | Protein kinase inhibitor H-7 dihydrochloride | H-7 dihydrochloride | PKC |
Protein kinase inhibitor H-7 dihydrochloride(H-7 dihydrochloride) is a potent protein kinase C (PKC) inhibitor. Protein kinase inhibitor H-7 dihydrochloride (100 μM) significantly inhibits TPA (skin tumor promoter, 12-O-... | |||
T39482 | Casein Kinase inhibitor A86 | Casein Kinase inhibitor A86 | |
Casein Kinase inhibitor A86 is a highly effective and orally bioavailable inhibitor of casein kinase 1α (CK1α). Additionally, it displays inhibitory actions towards CDK7 (TFIIH) and CDK9 (P-TEFb). Furthermore, Casein Kin... | |||
T79860 | TIE-2/VEGFR-2 kinase-IN-5 | VEGFR , Tie-2 | |
TIE-2/VEGFR-2 kinase-IN-5 is a potent TIE-2 and VEGFR-2 tyrosine kinase receptor inhibitor with anti-angiogenic activity and is commonly used in biomedical research related to angiogenesis. | |||
T35525 | PI3-Kinase α Inhibitor 2 | PI3-Kinase α Inhibitor 2 | |
Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of the 3' hydroxyl position of PIs to produce the second messengers PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3. PI3Kα, β, and δ are class 1A enzymes composed ... | |||
T77526 | Pim-1 kinase inhibitor 4 | Apoptosis , Pim | |
Pim-1 kinase inhibitor 4 is a potent Pim-1 kinase inhibitor with an IC50 value of 17.01 nM.Pim-1 kinase inhibitor 4 also possesses antioxidant activity and potential anticancer activity, and inhibits DPPH.Pim-1 kinase in... | |||
T37248 | Pantothenate Kinase Inhibitor | ||
Pantothenate Kinase Inhibitor (PANKi) is a reversible inhibitor of pantothenate kinase (PanK; IC50s = 70, 92, and 25 nM for PanK1β, PanK2, and PanK3, respectively), the rate-limiting enzyme in the synthesis of coenzyme A... | |||
T35526 | PI3-Kinase α Inhibitor 2 (hydrochloride) | PI3-Kinase α Inhibitor 2 (hydrochloride) | |
PI3-Kinase α Inhibitor 2 (hydrochloride) is a PI3-Kinase α inhibitor. |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
TN1433 | Batatasin III | FAK , Others , Akt | |
Batatasin III inhibits cancer migration and invasion by suppressing epithelial to mesenchymal transition and FAK-AKT signals and possesses anti-cancer activities. Batatasin III has a long-term inhibitory effect on whole-... | |||
TQ0183 | Narciclasine | Lycoricidinol | ROCK |
Narciclasine (Lycoricidinol), a natural product, modulates the Rho/Rho-kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity. | |||
T8152 | 6-Demethoxytangeretin | MAPK , ALK | |
6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus depressa. | |||
T6677 | Sophocarpine | ERK , p38 MAPK , NF-κB , TLR , COX , HER , JNK , STAT | |
Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects. | |||
T0809 | Dicoumarol | Dicumarol | Dehydrogenase , NADPH , PDK |
Dicoumarol (Dicumarol) is a hydroxycoumarin originally isolated from molding sweet-clover hay, with anticoagulant and vitamin K depletion activities. Dicoumarol is a competitive inhibitor of vitamin K epoxidereductase; t... | |||
T5654 | Musk ketone | Others | |
Musk ketone can induce the growth repression and the apoptosis of cancer cells. Musk ketone increases activity of glutathione S-transferase and thus may prove to be useful cancer chemoprotectant. | |||
T2851 | Daphnetin | 7,8-Dihydroxycoumarin,Daphnetol | EGFR , PKA , PKC , Parasite , Autophagy |
Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM), and PKC (IC50: 25.01 μM), also exhibit anti-oxidant and anti-... | |||
TN1828 | Kahweol | Apoptosis , NF-κB , AMPK | |
Kahweol has anticarcinogenic, anti-angiogenic,and anti-inflammatory activities, it can block the LPS-induced activation of NF-kappaB by preventing IkappaB degradation and inhibiting IkappaB kinase activity. | |||
T5796 | Plantainoside D | Isoplantamajoside | RAAS , PKC |
Plantainoside D (Isoplantamajoside) shows potent antioxidative effects as those of ascorbic acid, it shows angiotensin-converting enzyme (ACE) inhibitory inhibitory activity in vitro with the IC(50) value of 2.17 mM, it ... | |||
T2S2215 | Crebanine | Apoptosis , Others , Akt | |
1. Crebanine iv 5mg/kg can eonvert BaCl_2-induced arrhythmia into sinus rhythm in rats, and can significantly increase the tolerant dose of aconitine to produce ventrieular fibrillation(VF) and cardiac arrest (CA) in rat... | |||
T4S1796 | Heterophyllin B | PI3K | |
Heterophyllin B effectively suppresses the adhesion and invasion of the human esophageal carcinoma cells by mediating the PI3K/AKT/β-catenin pathways and regulating the expression levels of adhesion- and invasion-associa... | |||
TN1557 | Decursinol angelate | ERK , VEGFR , PKC , JNK | |
Decursinol angelate has anti-tumor, anti-inflammatory, anti-oxidant, and hepatoprotective activities, it inhibits VEGF-induced angiogenesis via suppression of the VEGFR-2-signaling pathway; it also suppresses invasion an... | |||
T2836 | Isorhamnetin | 3-methylquercetin,3'-Methylquercetin,Isorhamnetol,3'-Methoxyquercetin | MEK , PI3K , Endogenous Metabolite |
Isorhamnetin (3-methylquercetin) is the methylated metabolite of quercetin. Quercetin is an important dietary flavonoid with in vitro antioxidant activity. Isorhamnetin prevents endothelial cell injuries from oxidized LD... | |||
TMS1743 | Salvigenin | MAO , Autophagy , ROS Kinase | |
Salvigenin is a potent hMAO-A inhibitor, has neuroprotective, antitumor and immunomodulatory effects. | |||
TN1299 | Desmethylglycitein | 6,7,4'-Trihydroxyisoflavone | PI3K , CDK , PKC |
Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) , is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which has antioxidant, and anti-cancer activities. | |||
T3889 | Platycodin D | Prostaglandin Receptor , AMPK | |
Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA. Platycodin D (10/30 μM) suppresses prostaglandin E2 production in rat peritoneal macrophages stimulated by the protein kinase C activator 1... | |||
TN1100 | Nepodin | transporter , COX , AMPK , Parasite | |
Nepodin has antimalarial, and anti-inflammatory activities, it shows significant cyclooxygenase (COX) inhibitory activity. Nepodin has an antidiabetic effect, which is at least partly mediated by stimulation of GLUT4 tra... | |||
T4672 | Brevilin A | Apoptosis , Anti-infection , JAK , STAT , Autophagy | |
Brevilin A is a sesquiterpene lactone isolated from Centipeda minima, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells with anti-tumor activity. Brevilin A is a selective inhibitor of JAK-STAT si... | |||
T5771 | Hypocrellin A | Antibacterial , PKC , Parasite | |
Hypocrellin A is PKC inhibitor, has light-induced antitumor,antifungal and antiviral activities, it also exerts immunomodulatory effects on MHC-restricted presentation of antigen. | |||
T2798 | Esculetin | Aesculetin,Cichorigenin | Lipoxygenase , Akt , PI3K |
Esculetin (Cichorigenin) is a coumarin derivative from various natural plant products with various biological and pharmaceutical properties including anti-edema, anti-inflammatory and anti-tumour effects. It inhibits lip... | |||
T7190 | Actein | Apoptosis , Akt , JNK , Autophagy | |
Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis, it also can prevent oxidative damage to osteoblasts in osteoporotic patients. Actein's ability to pathways in... | |||
T2746 | Sophocarpine monohydrate | Sophocarpine | Apoptosis , Influenza Virus , Akt , PI3K , AMPK , Autophagy |
Sophocarpine monohydrate, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects. | |||
TMS2181 | Trans-Zeatin | (E)-Zeatin | ERK , MEK , Endogenous Metabolite |
trans-Zeatin ((E)-Zeatin) is the member of the plant growth hormone family known as cytokinins, which regulate cell division, development, and nutrient processing. | |||
T6S1302 | Carnosol | Nrf2 , Endogenous Metabolite , S6 Kinase | |
Carnosol is an Nrf2 activator, increasing Nrf2 levels and promoting heme oxygenase 1 (HMOX1) expression. It is a ribosomal S6 kinase (RSK2) inhibitor and can be used in gastric cancer-related research with an IC50 value ... | |||
T4S0498 | Glaucocalyxin A | Wangzaozin B,Leukamenin F | Apoptosis , Akt , Caspase , PI3K |
1. Glaucocalyxin A (Leukamenin F)-SBE-β-CD could be useful with a better solubility and sustained function in drug delivery. 2. Glaucocalyxin A activates caspase-3, decreases BAD phosphorylation, and reduces the expressi... | |||
T1711 | Harmine | Telepathine | MAO , 5-HT Receptor , DYRK |
Harmine (Telepathine) is an alkaloid isolated from seeds of Peganum harmala. | |||
TN1405 | Arnicolide D | Akt , Caspase , PI3K , STAT , mTOR | |
Arnicolide D is a sesquiterpene lactone. Arnicolide D isolates from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling path... | |||
TN1134 | Euscaphic acid | Apoptosis , LDL , PI3K , DNA/RNA Synthesis , NO Synthase , Prostaglandin Receptor | |
Euscaphic acid has anti-diabetic, and anti-inflammatory activities, it inhibits LPS-induced inflammatory responses by interference with the clustering of TRAF6 with IRAK1 and TAK1, resulting in blocking the activation of... | |||
T7327 | 7-Methoxyisoflavone | AMPK | |
7-Methoxyisoflavone is an activator of adenosine monophosphate-activated protein kinase (AMPK). | |||
T3836 | Eudesmin | MAPK , S6 Kinase | |
Eudesmin shows antiinflammatory, neuritogenic, anticonvulsant and sedative effects, the mechanism of eudesmin may be related to up-regulation of GABAA and GAD65 expressions, and anti-apoptosis of neuron the in brain.50 m... | |||
T3826 | Polygalasaponin F | NF-κB , TLR , Akt , PI3K | |
Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and reduce the expression of inducible nitric oxide synthases. Po... | |||
T2869 | Emodin | Frangula emodin | SARS-CoV , Casein Kinase , Autophagy |
Emodin (Frangula emodin) is a naturally occurring anthraquinone present in the roots and barks of numerous plants; exerts antiproliferative effects in Y cells that are regulated by different signaling pathways. | |||
T5S0761 | Nitidine chloride | Apoptosis , ERK , FAK , p38 MAPK , NF-κB , Topoisomerase , STAT , Parasite | |
1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721 cells in vitro in a time- and dose-dependent manner and id... | |||
T5S1467 | Cucurbitacin E | CDK , Autophagy | |
Cucurbitacin E is a natural product isolated from the climbing stem of Cucumic melo L. It significantly suppresses the activity of the cyclin B1/CDC2 complex.Cucurbitacin E has prevention of neurodegeneration, it has pot... | |||
T7030 | Anemarsaponin B | p38 MAPK , NF-κB , MEK , COX , NO Synthase | |
Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activity, possibly via the p38 MAP kinase pathway. Anemarsaponin B c... | |||
T4S0800 | Demethyleneberberine | P450 , NOS , NF-κB , HIF , AMPK | |
Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria either in vitro or in vivo.Demethyleneberberine suppresses CYP2E1,... | |||
T2811 | Harmine hydrochloride | telepathine hydrochloride | 5-HT Receptor , DYRK , GluR |
Harmine hydrochloride (telepathine hydrochloride) is extracted from Peganum Harmala Genus. | |||
T16324 | Nimbolide | Apoptosis , NF-κB , CDK | |
Nimbolide suppresses CDK4/CDK6 kinase activity. Nimbolide inhibits the NF-κB, Wnt, PI3K-Akt, MAPK, and JAK-STAT signaling pathways. Nimbolide causes apoptosis through the inactivation of NF-κB. Nimbolide is a triterpene ... | |||
T3904 | Gomisin J | Calcium Channel , AMPK | |
Gomisin J is a natural product and have vasodilatory activity. Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic enzymes and inflammatory molecules through activation of AMPK... | |||
T3881 | Vaccarin | Integrin , Akt , PERK , AMPK | |
Vaccarin is a major flavonoid glycoside in Vaccariae semen, its biotransformation pathways involves methylation, hydroxylation, glycosylation and deglycosylation. | |||
TN4673 | (+)-Nortrachelogenin | Wikstromol | Apoptosis , HIV Protease , PI3K , Antifection |
(+)-Nortrachelogenin is a lignan isolated from Wikstroemia indica C.A. Meyer (Thymelaeaceae). (+)-Nortrachelogenin possesses antileukemic activity. | |||
T5740 | 25(R,S)-Ruscogenin | (25RS)-Ruscogenin | Others , HIF |
25(R,S)-Ruscogenin is a natual product. | |||
TJS1779 | Protosappanin A | PTA | NADPH-oxidase , IL Receptor , IκB/IKK , TNF , NF-κB , TLR , ROS , COX , HIV Protease , JAK , NO Synthase , STAT |
Protosappanin A (PTA) has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB inflammation signal pathway; it exerts anti-neuroinflammatory ... | |||
T6630 | Quercetin Dihydrate | Sophoretin | Apoptosis , PI3K |
Quercetin Dihydrate (Sophoretin) is a polyphenolic flavonoid that was found in a wide variety of plant-based foods, such as apples, onions, berries, and red wine. It is used for their nervous system and anticancer effect... | |||
T5497 | AMAROGENTIN | Apoptosis , AMPK | |
Amarogentin is mainly extracted from Swertia and Gentiana roots. It plays cemopreventive/therapeutic role during liver carcinogenesis through modulation of cell cycle and apoptosis | |||
T2933 | Wogonin | Vogonin | Apoptosis , Wnt/beta-catenin , CDK , Autophagy |
Wogonin (Vogonin) is a cell-permeable and orally available flavonoid that displays anti-inflammatory and anticancer properties. | |||
T1558 | Resveratrol | trans-Resveratrol,SRT 501 | Apoptosis , Mitophagy , IκB/IKK , Lipoxygenase , Sirtuin , COX , NADPH , DNA/RNA Synthesis , Nrf2 , Antibacterial , Antibiotic , Autophagy , Antifungal |
Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities. Resveratrol has a wide range of targets including COX, SIRT, LOC, etc. Resveratrol induces autop... | |||
T0167 | Vinpocetine | RGH-4405,Ethyl apovincaminate | IκB/IKK , NF-κB , Sodium Channel , PDE |
Vinpocetine (RGH-4405) is a selective inhibitor of cyclic GMP phosphodiesterase (PDE). | |||
T3122 | Fangchinoline | Tetrandrine B,(+)-Limacine,Hanfangichin B,(+)-Fangchinoline | Apoptosis , FAK , HIV Protease , Autophagy |
Fangchinoline (Tetrandrine B) is extracted from Stephania tetrandra S. Moore. | |||
T5S0896 | Loureirin A | Akt , PI3K | |
Loureirin A has an inhibitory effect on platelet activation, perhaps through an impairment of PI3K/Akt signaling.Loureirin A negatively affects agonist-induced platelet aggregation such as collagen, collagen-related pept... | |||
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カタログ番号 | 製品名 | Species | Expression System |
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TMPY-04172 | Adenylate Kinase 1 Protein, Rat, Recombinant (His) | Rat | E. coli |
Adenylate Kinase 1 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 23.8 kDa and the accession number is A6JU73. | |||
TMPY-04412 | Germinal Center Kinase/MAP4K2 Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells |
Mitogen-activated protein kinase kinase kinase kinase 2, also known as B lymphocyte serine/threonine-protein kinase, Germinal center kinase, MAPK/ERK kinase kinase kinase 2, MEK kinase kinase 2, Rab8-interacting protein,... | |||
TMPH-00603 | Cytidylate kinase Protein, E. coli, Recombinant (His & SUMO) | E. coli | E. coli |
ATP, dATP, and GTP are equally effective as phosphate donors. CMP and dCMP are the best phosphate acceptors. | |||
TMPY-04432 | Sphingosine Kinase 1/SPHK1 Protein, Human, Recombinant | Human | Baculovirus Insect Cells |
Sphingosine Kinase 1/SPHK1 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 42.7 kDa and the accession number is Q9NYA1-1. | |||
TMPY-04470 | Adenylate Kinase 1 Protein, Human, Recombinant (His) | Human | E. coli |
Adenylate Kinase 1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 23.5 kDa and the accession number is AAH01116.1. | |||
TMPY-04422 | Casein Kinase 1 gamma 2 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
Casein kinase I gamma 2 isoform (CSNK1G2), a member of the large casein kinase I (CKI) subfamily, protein kinase superfamily. It may affect the development of brain, and associate with vesicular trafficking and neurotran... | |||
TMPY-04403 | NLK/Nemo Like Kinase Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells |
Nemo-like kinase contains 1 protein kinase domain and belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, and MAP kinase subfamily. It also contains a TQE activation loop motif in which autopho... | |||
TMPY-04385 | ZIP Kinase/DAPK3 Protein, Human, Recombinant (GST) | Human | Baculovirus Insect Cells |
Death-associated protein kinase 3, also known as DAP kinase 3, ZIP-kinase, DAPK3 and ZIPK, is a nucleus and cytoplasm protein which belongs to theprotein kinase superfamily, CAMK Ser/Thr protein kinase family and DAP ... | |||
TMPY-04375 | Casein Kinase 1 alpha Protein, Human, Recombinant (GST) | Human | Baculovirus Insect Cells |
Casein kinase I isoform alpha, also known as CKI-alpha, CK1 and CSNK1A1, is a cytoplasm protein which belongs to theprotein kinase superfamily, CK1 Ser/Thr protein kinase family and casein kinase I subfamily. Casein k... | |||
TMPY-04431 | Sphingosine Kinase 1/SPHK1 Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells |
Sphingosine Kinase 1/SPHK1 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 70.3 kDa and the accession number is Q9NYA1-1. | |||
TMPH-03088 | Arginine kinase/AK Protein, Penaeus monodon, Recombinant (His & SUMO) | Penaeus monodon | E. coli |
N/A. Arginine kinase/AK Protein, Penaeus monodon, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 56.0 kDa and the accession number is C7E3T4. | |||
TMPY-04356 | GSK3B Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
GSK3B Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 50.4 kDa and the accession number is P49841-2. | |||
TMPY-04761 | Creatine kinase B Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
CKB(Creatine kinase B type) contains 1 phosphagen kinase C-terminal domain and 1 phosphagen kinase N-terminal domain. It belongs to the ATP:guanido phosphotransferase family. CKB consists of a homodimer of two identical... | |||
TMPY-04406 | Protein Kinase D2/PRKD2 Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells |
Serine/threonine-protein kinase D2, also known as PRKD2 and PKD2, is a cytoplasm and membrane protein that belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family and PKD subfamily. PRKD2 / PKD2 is ... | |||
TMPH-03503 | Adenylate kinase Protein, Shigella flexneri, Recombinant (His & Myc & SUMO) | Shigella flexneri | E. coli |
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase Protein, Shigella flexn... | |||
TMPY-04750 | CSNK2A2 Protein, Human, Recombinant | Human | Baculovirus Insect Cells |
CSNK2A2 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 41.4 kDa and the accession number is P19784. | |||
TMPY-04480 | UMP-CMP kinase/CMPK1 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
CMPK1 plays a key role in the maintenance of pyrimidine nucleotide pool profile and for the metabolism of pyrimidine analogs in cells. It catalyzes the phosphoryl transfer from ATP to UMP, CMP, and deoxy-CMP (dCMP), re... | |||
TMPY-00246 | HER3/ERBB3 Protein, Rhesus, Recombinant | Rhesus | HEK293 Cells |
HER3/ERBB3 Protein, Rhesus, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 69.5 kDa and the accession number is XP_001113953.2. | |||
TMPY-00548 | HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (His) | Cynomolgus,Rhesus | HEK293 Cells |
HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 103.1 kDa and the accession number is G7MM61. | |||
TMPY-02813 | ErbB4 Protein, Human, Rhesus, Recombinant (His) | Human,Rhesus | HEK293 Cells |
ErbB4 Protein, Human, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.1 kDa and the accession number is Q15303-1. | |||
TMPY-02477 | HER3/ERBB3 Protein, Rhesus, Recombinant (His) | Rhesus | HEK293 Cells |
HER3/ERBB3 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.1 kDa and the accession number is XP_005571238.1&XP_001113953.2. | |||
TMPY-04572 | MKK4 Protein, Mouse, Recombinant (His & GST) | Mouse | Baculovirus Insect Cells |
Dual specificity mitogen-activated protein kinase kinase 4, also known as MAP kinase kinase 4, MAPKK4, JNK-activating kinase 1, MAPK/ERK kinase 4, SAPK/ERK kinase 1, c-Jun N-terminal kinase kinase 1, JNKK, and MAP2K4, is... | |||
TMPY-03024 | HER3/ERBB3 Protein, Rat, Recombinant (His) | Rat | HEK293 Cells |
HER3/ERBB3 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 69.9 kDa and the accession number is A6KSF8. | |||
TMPY-04751 | VRK1 Protein, Human, Recombinant | Human | Baculovirus Insect Cells |
VRK1 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 45.6 kDa and the accession number is Q99986. | |||
TMPY-04376 | PLK1 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
PLK1 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 70.5 kDa and the accession number is P53350. | |||
TMPY-04544 | MEK2 Protein, Human, Recombinant (GST) | Human | Baculovirus Insect Cells |
Dual specificity mitogen-activated protein kinase kinase 2, also known as MAP kinase kinase 2, MAPKK2, ERK activator kinase 2, MAPK / ERK kinase 2, MEK2 and MAP2K2, is a member of the protein kinase superfamily, STE Ser/... | |||
TMPY-01944 | HER2/ERBB2 Protein, Rat, Recombinant (His) | Rat | HEK293 Cells |
HER2/ERBB2 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.2 kDa and the accession number is AAH61863.1. | |||
TMPY-03719 | HER2/ERBB2 Protein, Canine, Recombinant (His) | Canine | HEK293 Cells |
HER2/ERBB2 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.4 kDa and the accession number is A8WED5. | |||
TMPY-00636 | HER2/ERBB2 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
HER2/ERBB2 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.8 kDa and the accession number is G7PUM4. | |||
TMPY-04548 | CDK4 Protein, Human, Recombinant (GST) | Human | Baculovirus Insect Cells |
CDK4 is a member of the Ser/Thr protein kinase family. It is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cel... | |||
TMPJ-00412 | VEGFR1/FLT-1 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Human Vascular endothelial growth factor receptor 1(VEGFR-1, FLT-1) is a member of the the class III subfamily of receptor tyrosine kinases (RTKs) and Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR-1 ... | |||
TMPY-01601 | AXL Protein, Human, Recombinant (His) | Human | HEK293 Cells |
AXL Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46.5 kDa and the accession number is AAB20305.1. | |||
TMPY-06873 | FLT3 Ligand Protein, Human, Recombinant | Human | E. coli |
FLT3 Ligand Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.75 kDa and the accession number is P49771-1. | |||
TMPY-03215 | FLT3 Ligand Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
FLT3 Ligand Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 20.2 kDa and the accession number is P49771-1. | |||
TMPY-03066 | FLT3 Ligand Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
FLT3 Ligand Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.4 kDa and the accession number is P49772-1. | |||
TMPY-04649 | ROR1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
ROR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.4 kDa and the accession number is Q01973. | |||
TMPY-00930 | TIE2 Protein, Human, Recombinant (His & hFc) | Human | HEK293 Cells |
TIE2 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 108.5 kDa and the accession number is AAA61139.1. | |||
TMPY-01064 | TIE2 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
TIE2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 82 kDa and the accession number is AAA61139.1. | |||
TMPY-05394 | ROR2 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
ROR2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.8 kDa and the accession number is Q01974. | |||
TMPY-01247 | FLT3 Protein, Human, Recombinant (T227M, His) | Human | HEK293 Cells |
FLT3 Protein, Human, Recombinant (T227M, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59.7 kDa and the accession number is P36888-1. | |||
TMPY-02361 | VEGFR2/KDR Protein, Human, Recombinant (His) | Human | HEK293 Cells |
VEGFR2/KDR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 84.6 kDa and the accession number is P35968-1. | |||
TMPY-00637 | FLT1 Protein, Human, Recombinant (aa 1-328, His) | Human | HEK293 Cells |
FLT1 Protein, Human, Recombinant (aa 1-328, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 35.6 kDa and the accession number is L7RSL3. | |||
TMPY-00882 | Mer Protein, Human, Recombinant (His & hFc) | Human | HEK293 Cells |
Mer Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 80 kDa and the accession number is Q12866. | |||
TMPY-01896 | HGFR/c-Met Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
HGFR/c-Met Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 102 kDa and the accession number is EDL13881.1. | |||
TMPY-04330 | Mer Protein, Human, Recombinant | Human | HEK293 Cells |
Mer Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 54 kDa and the accession number is Q12866. | |||
TMPY-01936 | VEGFR3/FLT4 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
VEGFR3/FLT4 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 86.4 kDa and the accession number is P35917-1. | |||
TMPJ-00778 | HER2/ERBB2 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
HER2/ERBB2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 90-120 KDa and the accession number is P04626. | |||
TMPY-04384 | Src Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells |
Src Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 87.7 kDa and the accession number is P12931-1. | |||
TMPY-02231 | TrkB Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
TrkB Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46 kDa and the accession number is P15209-2. | |||
TMPY-01296 | HGFR/c-Met Protein, Human, Recombinant (His) | Human | HEK293 Cells |
HGFR/c-Met Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 103 kDa and the accession number is A0A024R759. | |||
------------------------ More ------------------------ |
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L1600 | Kinase Inhibitor Library | 2720 compounds | |
A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases; | |||
L2200 | Tyrosine Kinase Inhibitor Library | 1016 compounds | |
A unique collection of 1016 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase related diseases; | |||
L1610 | FDA-Approved Kinase Inhibitor Library | 263 compounds | |
A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening. | |||
L1120 | AMPK-Targeted Compound Library | 80 compounds | |
80 well-chosen unique AMPK-targeted small molecules; | |||
L1300 | PI3K-AKT-mTOR Compound Library | 420 compounds | |
A unique collection of 420 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved with PI3K/Akt/mTOR signaling; | |||
L7700 | Neural Regeneration Compound Library | 524 compounds | |
A unique collection of 149 neuroregeneration related compounds for high throughput and high content screening; | |||
L2520 | Glycometabolism Compound Library | 702 compounds | |
702 glycometabolism-related comounds, can be used for HTS and HCT; | |||
L3800 | NF-κB Signaling Compound Library | 729 compounds | |
A unique collection of 729 compounds targeting NF-κB signaling for high throughput screening and high content screening; | |||
L1400 | MAPK Inhibitor Library | 365 compounds | |
A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases; | |||
L8000 | Stem Cell Differentiation Compound Library | 1197 compounds | |
A unique collection of 1197 stem cell differentiation signaling targeted compounds for high throughput and high content screening; | |||
L2191 | Anti-Breast Cancer Compound Library | 1939 compounds | |
A unique collection of 1939 compounds with anti-breast cancer therapeutic activity or targeting breast cancer’s major signaling pathways, can be used for anti-breast cancer drug discovery and mechanism study; | |||
L9410 | Covalent Inhibitor Library | 1920 compounds | |
A unique collection of 1920 covalent Inhibitors and other molecules with common warheads like chloroacetyl,2-Chloropropionyl,Acryloyl,sulfonyl fluoride, alkyne,acrylamide, ketocarbonyl,disulfide bond, etc. |