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Search Results for " AKT Kinase Inhibitor "

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天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T10276	AKT Kinase Inhibitor		Akt
			Akt
T10276L	AKT Kinase Inhibitor HCl	AKT Kinase Inhibitor HCl(842148-40-7 Free base)	Akt
	AKT Kinase Inhibitor HCl is an Akt inhibitor with antitumor activity.		Akt
T5508	PF-AKT400	AKT protein kinase inhibitor	Akt
	PF-AKT400 (AKT protein kinase inhibitor) is a broadly selective and ATP-competitive inhibitor of Akt.		Akt
T3346	AKT inhibitor VIII	AKTi-1/2	Apoptosis , Akt
	AKT inhibitor VIII (AKTi-1/2) is a highly specific Akt1/2 inhibitor (IC50: 58/210 nM). The selectivity for Akt1 is higher about 36-fold than Akt3.		Apoptosis , Akt
T72104	AKT Kinase Inhibitor hydrochloride
	AKT Kinase Inhibitor hydrochloride is an Akt kinase inhibitor with anti-tumor activity .
T8427	Borussertib		Akt
	Borussertib is a covalent-allosteric and first-in-class inhibitor of protein kinase Akt(IC50 of 0.8 nM and a Ki of 2.2 nM for Aktwt)		Akt
T14034	3CAI		Akt
			Akt
T9393	(E)-Akt inhibitor-IV	(E)-AKTIV,CS-1992	Akt
	(E)-Akt inhibitor-IV ((E)-AKTIV) ((E)-AKTIV) is an inhibitor of PI3K-Akt.		Akt
T3467	Miransertib	ARQ-092,AKT inhibitor 2	Akt , Parasite
	Miransertib (ARQ-092) is an orally bioavailable, selective, and potent allosteric Akt inhibitor.		Akt , Parasite
T7885	Afuresertib hydrochloride		ROCK , Akt , PKC
	Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)		ROCK , Akt , PKC
T7315	BAY1125976		Akt
	BAY1125976 is an allosteric inhibitor of Akt1 and Akt2 (IC50s of 5.2 and 18 nM, respectively, in a time-resolved FRET assay)		Akt
T14072	A-443654		ERK , VEGFR , GSK-3 , FLT , Casein Kinase , MAPK , Akt , PKA , Chk , CDK , Src , PKC , S6 Kinase
	A-443654 is a pan-Akt inhibitor. A-443654 has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).
T8969	API-1	NSC177223	Akt
	API-1 (NSC-177223) is a potent inhibitor of Akt. It induces GSK3-dependent, β-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis .		Akt
T6997	SU6656		FAK , Akt , Src
	SU 6656 is a selective inhibitor of Src family kinases, with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively.		FAK , Akt , Src
T6304	AT7867		Akt , PKA , S6 Kinase
	AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively; little activity outside the AGC kinase family.		Akt , PKA , S6 Kinase
T6139	A-674563	A674563	ERK , GSK-3 , Akt , PKA , CDK
	A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.		ERK , GSK-3 , Akt , PKA , CDK
T3132	SC66		Apoptosis , Akt
	SC66 is a AKT inhibitor in HepG2, HA22T/VGH, and PLC/PRF/5 cells (IC50: about 0.75 μg/ml, at 72 h).		Apoptosis , Akt
T13862	Recilisib	Ex-RAD,ON 01210	Akt , PI3K
	Recilisib (ON 01210) is a radioprotectant,can activate AKT, PI3K activities in cells.		Akt , PI3K
T6285	GSK-690693	GSK690693	Serine Protease , Akt , PKC , AMPK , Autophagy
	GSK-690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1.		Serine Protease , Akt , PKC , AMPK , Autophagy
T2482	AT13148		ROCK , SGK , Akt , PKA , S6 Kinase
	AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.		ROCK , SGK , Akt , PKA , S6 Kinase
T7879	TASP0415914		Akt , PI3K
	TASP0415914 is an orally potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ). T		Akt , PI3K
T13376	YS-49		RAAS , Akt , PI3K , Adrenergic Receptor
	YS-49 is an activator of PI3K/Akt (a downstream target of RhoA).		RAAS , Akt , PI3K , Adrenergic Receptor
T1911	Afuresertib	GSK2110183C,GSK2110183	ROCK , Akt , PKC
	Afuresertib (GSK2110183) is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity.		ROCK , Akt , PKC
T4489	AKT-IN-1	AZD26,AZD-26,AZD 26	Akt
	AKT-IN-1 (AZD-26) is an allosteric AKT inhibitor (IC50: 1.04 μM).		Akt
T1920	Capivasertib	AZD5363	Akt , PKA , mTOR , Autophagy
	Capivasertib (AZD5363) is a broad-spectrum AKT inhibitor with inhibitory activity against Akt1, Akt2, and Akt3 (IC50=3/7/7 nM) with oral activity. Capivasertib has antitumor activity for the treatment of breast cancer.		Akt , PKA , mTOR , Autophagy
T1967	AZD-3463	ALK/IGF1R inhibitor	Apoptosis , IGF-1R , ALK , Autophagy
	AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.		Apoptosis , IGF-1R , ALK , Autophagy
T2042	CTX-0294885		Others
	CTX-0294885, a novel bisanilino pyrimidine, exhibits inhibitory activity against a broad range of kinases in vitro and is further developed into a Sepharose-supported kinase capture reagent.		Others
T4496	LM22B-10	LM22B10	ERK , Trk receptor , Akt
	LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor and can induce TrkB, TrkC, ERK and AKT activation in vitro and in vivo.		ERK , Trk receptor , Akt
T0033	Miltefosine	HePC,Hexadecyl phosphocholine	Akt , HIV Protease , PKC
	Miltefosine (HePC) is the treatment of visceral and cutaneous leishmaniasis drug , and is proceeding clinical trials for this in several countries. Several medical agents produce some potency against visceral or cutaneou...		Akt , HIV Protease , PKC
T13416	ZX-29		ALK
	ZX-29 is a potent and selective inhibitor of ALK(IC50 of 2.1 nM, 1.3 nM and 3.9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively), and also induces protective autophagy and has antitumor effect.		ALK
T14327	AS1949490		Phosphatase
	AS1949490 activated glucose metabolism via up-regulation of GLUT1 gene in L6 myotubes[1][2]. AS1949490 is a potent and selective SHIP-2 (SH2 domain-containing inositol 5′ phosphatase 2) inhibitor, with an IC50 of 620 nM.		Phosphatase
T0708	Oxaprozin	Oxaprozinum,Wy21743	NF-κB , COX
	Oxaprozin (Oxaprozinum) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of oxaprozin is as a Cyclooxygenase Inhibitor. The chemical classification of oxaprozin is Nonsteroidal Anti-inflammatory Compound...		NF-κB , COX
TP1197	Sincalide	SQ19844,CCK-8,Cholecystokinin octapeptide	Others
	Sincalide (CCK-8) is a cholecystokinetic drug administered by injection to aid in diagnosing disorders of the gallbladder and pancreas. It is the 8-amino acid C-terminal fragment of cholecystokinin.		Others
T2420	PHT-427	PHT 427,CS-0223	Apoptosis , Akt , PDK
	PHT-427 (CS-0223) is a dual Akt (Ki: 2.7 μM) and PDPK1 (Ki: 5.2 μM) inhibitor (high-affinity binding for the PH domains of Akt and PDPK1).		Apoptosis , Akt , PDK
T1921	Alpelisib	BYL-719	PI3K
	Alpelisib (BYL-719) is a PI3Kα inhibitor (IC50=5 nM) with selective, potent, and oral activity. Alpelisib inhibits PI3Kβ/γ/δ with low activity (IC50=250/290/1200 nM). Alpelisib has antitumor activity and is targeted to P...		PI3K
T6849	Uprosertib	GSK2141795,GSK795	Akt
	Uprosertib (GSK2141795) (GSK2141795) is a selective, ATP-competitive, and orally bioavailable Akt inhibitor with IC50 of 180 nM, 328 nM, and 38 nM for Akt 1, 2 and 3, respectively. Phase 2.		Akt
T7506	Yoda 1		Piezo Channel
	Yoda1 is a Piezo1 ion channel agonist (EC50s = 17.1 and 26.6 μM for murine and human Piezo1-transfected HEK293T cells, respectively)		Piezo Channel
T12412L	PDK4-IN-1 hydrochloride		Apoptosis , PDK
			Apoptosis , PDK
T6303	CCT128930		Akt , PKA , S6 Kinase , Autophagy
	CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2 with IC50 of 6 nM, 28-fold greater selectivity for Akt2 than the closely related PKA kinase.		Akt , PKA , S6 Kinase , Autophagy
T6252	Ipatasertib	GDC-0068,RG7440	Akt
	Ipatasertib (GDC-0068) (GDC-0068), a highly specific pan-Akt inhibitor, targets Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM, respectively.		Akt
T6322	Copanlisib	BAY 80-6946	Apoptosis , PI3K
	Copanlisib (BAY 80-6946) is a phosphoinositide 3-kinase (PI3K) inhibitor with potential antineoplastic activity. Copanlisib inhibits the activation of the PI3K signaling pathway, which may result in inhibition of tumor c...		Apoptosis , PI3K
T8719	SC99		Apoptosis , JAK , STAT
	SC99 is a selective inhibitor of JAK2-STAT3 activation. SC99 downregulates the expression of STAT3-modulated genes.SC99 inhibits platelet activation, aggregation and displays potent anti-myeloma, anti-thrombotic activiti...		Apoptosis , JAK , STAT
T3626	Acalabrutinib	ACP-196	BTK
	Acalabrutinib (ACP-196), also known as ACP-196, is an orally available inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. Upon administration, ACP-196 inhibits the activity of BTK and pre...		BTK
TQ0138	K145 hydrochloride		Apoptosis , S1P Receptor
			Apoptosis , S1P Receptor
T2274	SC79	SC 79	Akt
	SC79 is an AKT agonist with specificity and blood-brain barrier permeability. SC79 specifically binds to the PH domain of AKT, activates cytoplasmic AKT, and inhibits AKT membrane translocation. SC79 has neuroprotective ...		Akt
T3198L	PRE-084 hydrochloride		Sigma receptor
	PRE-084 hydrochloride is a selective agonist of σ1(IC50:44 nM, in the sigma receptor assay).		Sigma receptor
T14998	Copanlisib dihydrochloride	BAY 80-6946 dihydrochloride	Apoptosis , PI3K , mTOR
	Copanlisib dihydrochloride (BAY 80-6946 dihydrochloride) is an ATP-competitive pan-class I PI3K inhibitor (IC50s: 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ). Copanlisib dihydrochloride has super...		Apoptosis , PI3K , mTOR
T2171	SEW2871	SEW2871	S1P Receptor , LPL Receptor
	SEW 2871 is an orally available, highly selective S1P1 agonist with an EC50 of 13.8 nM.It reduces the number of lymphocytes in the blood and is used in studies related to diabetes, Alzheimer's disease, liver fibrosis, an...		S1P Receptor , LPL Receptor
T9831	MKC-1	Ro-31-7453	Apoptosis , Akt , Microtubule Associated , mTOR
	MKC-1 (Ro-31-7453) is an orally bioavailable, small-molecule, bisindolylmaleimide cell cycle inhibitor with potential antineoplastic activity. MKC-1 and its metabolites inhibit tubulin polymerization, blocking the format...		Apoptosis , Akt , Microtubule Associated , mTOR
T2492	Perifosine	NSC 639966,D21266,KRX-0401	Apoptosis , Akt , Autophagy
	Perifosine (KRX-0401) is an oral-active, alkyl-phosphocholine Akt inhibitor with potential antineoplastic activity.		Apoptosis , Akt , Autophagy

Compounds

AKT Kinase Inhibitor

T10276

Synonym:

Target: Akt

AKT Kinase Inhibitor HCl

T10276L

Synonym: AKT Kinase Inhibitor HCl(842148-40-7 Free base)

Target: Akt

PF-AKT400

T5508

Synonym: AKT protein kinase inhibitor

Target: Akt

AKT inhibitor VIII

T3346

Synonym: AKTi-1/2

Target: Apoptosis, Akt

AKT Kinase Inhibitor hydrochloride

(E)-Akt inhibitor-IV

T9393

Synonym: (E)-AKTIV,CS-1992

Target: Akt

Miransertib

T3467

Synonym: ARQ-092,AKT inhibitor 2

Target: Akt, Parasite

Afuresertib hydrochloride

T7885

Synonym:

Target: ROCK, Akt, PKC

Target: ERK, VEGFR, GSK-3, FLT, Casein Kinase, MAPK, Akt, PKA, Chk, CDK, Src, PKC, S6 Kinase

Target: FAK, Akt, Src

AT7867

T6304

Synonym:

Target: Akt, PKA, S6 Kinase

A-674563

T6139

Synonym: A674563

Target: ERK, GSK-3, Akt, PKA, CDK

SC66

T3132

Synonym:

Target: Apoptosis, Akt

Recilisib

T13862

Synonym: Ex-RAD,ON 01210

Target: Serine Protease, Akt, PKC, AMPK, Autophagy

AT13148

T2482

Synonym:

Target: ROCK, SGK, Akt, PKA, S6 Kinase

Target: RAAS, Akt, PI3K, Adrenergic Receptor

Afuresertib

T1911

Synonym: GSK2110183C,GSK2110183

Target: ROCK, Akt, PKC

AKT-IN-1

T4489

Synonym: AZD26,AZD-26,AZD 26

Target: Akt, PKA, mTOR, Autophagy

AZD-3463

T1967

Synonym: ALK/IGF1R inhibitor

Target: Apoptosis, IGF-1R, ALK, Autophagy

Target: ERK, Trk receptor, Akt

Miltefosine

T0033

Synonym: HePC,Hexadecyl phosphocholine

Target: Akt, HIV Protease, PKC

Synonym: Oxaprozinum,Wy21743

Target: NF-κB, COX

Sincalide

TP1197

Synonym: SQ19844,CCK-8,Cholecystokinin octapeptide

Target: Others

PHT-427

T2420

Synonym: PHT 427,CS-0223

Target: Apoptosis, Akt, PDK

Synonym: GSK2141795,GSK795

Target: Piezo Channel

PDK4-IN-1 hydrochloride

T12412L

Synonym:

Target: Apoptosis, PDK

CCT128930

T6303

Synonym:

Target: Akt, PKA, S6 Kinase, Autophagy

Ipatasertib

T6252

Synonym: GDC-0068,RG7440

Target: Apoptosis, PI3K

SC99

T8719

Synonym:

Target: Apoptosis, JAK, STAT

Target: Apoptosis, S1P Receptor

PRE-084 hydrochloride

T3198L

Synonym:

Target: Sigma receptor

Copanlisib dihydrochloride

T14998

Synonym: BAY 80-6946 dihydrochloride

Target: Apoptosis, PI3K, mTOR

SEW2871

T2171

Synonym: SEW2871

Target: S1P Receptor, LPL Receptor

MKC-1

T9831

Synonym: Ro-31-7453

Target: Apoptosis, Akt, Microtubule Associated, mTOR

Perifosine

T2492

Synonym: NSC 639966,D21266,KRX-0401

Target: Apoptosis, Akt, Autophagy

カタログ番号	製品名	別名	ターゲット
T2S2215	Crebanine		Apoptosis , Others , Akt
	1. Crebanine iv 5mg/kg can eonvert BaCl_2-induced arrhythmia into sinus rhythm in rats, and can significantly increase the tolerant dose of aconitine to produce ventrieular fibrillation(VF) and cardiac arrest (CA) in rat...		Apoptosis , Others , Akt
T5654	Musk ketone		Others
	Musk ketone can induce the growth repression and the apoptosis of cancer cells. Musk ketone increases activity of glutathione S-transferase and thus may prove to be useful cancer chemoprotectant.		Others
T7190	Actein		Apoptosis , Akt , JNK , Autophagy
	Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis, it also can prevent oxidative damage to osteoblasts in osteoporotic patients. Actein's ability to pathways in...		Apoptosis , Akt , JNK , Autophagy
TN1433	Batatasin III		FAK , Others , Akt
	Batatasin III inhibits cancer migration and invasion by suppressing epithelial to mesenchymal transition and FAK-AKT signals and possesses anti-cancer activities. Batatasin III has a long-term inhibitory effect on whole-...		FAK , Others , Akt
T6677	Sophocarpine		ERK , p38 MAPK , NF-κB , TLR , COX , HER , JNK , STAT
	Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.		ERK , p38 MAPK , NF-κB , TLR , COX , HER , JNK , STAT
T5S0896	Loureirin A		Akt , PI3K
	Loureirin A has an inhibitory effect on platelet activation, perhaps through an impairment of PI3K/Akt signaling.Loureirin A negatively affects agonist-induced platelet aggregation such as collagen, collagen-related pept...		Akt , PI3K
T17280	(Z)-Guggulsterone		Apoptosis , VEGFR , Akt
	(Z)-Guggulsterone inhibits the growth of human prostate cancer cells by causing apoptosis. Z-guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis.		Apoptosis , VEGFR , Akt
T3844	Deltonin		ERK , Others , Akt , Endogenous Metabolite
	Deltonin has an inhibition of ERK1/2 and AKT activation. Deltonin shows cytotoxicity against human HepG2 cells (IC50: 7.66 μM), mouse C26 cells (IC50: 1.22 μM), and human MDA-MB-231 cells (IC50: 1.58 μM).		ERK , Others , Akt , Endogenous Metabolite
T6S0781	Phellodendrine	Phallodendrin	Others , NF-κB , Akt
	1. Phellodendrine (Phallodendrin) has anti-nephritic activity, may be due to its ability to inhibit the proliferation or the migration of macrophages and cytotoxic T lymphocytes in the glomeruli.		Others , NF-κB , Akt
T2746	Sophocarpine monohydrate	Sophocarpine	Apoptosis , Influenza Virus , Akt , PI3K , AMPK , Autophagy
	Sophocarpine monohydrate, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
T2798	Esculetin	Aesculetin,Cichorigenin	Lipoxygenase , Akt , PI3K
	Esculetin (Cichorigenin) is a coumarin derivative from various natural plant products with various biological and pharmaceutical properties including anti-edema, anti-inflammatory and anti-tumour effects. It inhibits lip...		Lipoxygenase , Akt , PI3K
T13803	N-Oleoyl glycine		Cannabinoid Receptor , Akt , Endogenous Metabolite , PPAR
	N-Oleoyl Glycine, a Lipoamino Acid, Stimulates Adipogenesis Associated With Activation of CB1 Receptor and Akt Signaling Pathway in 3T3-L1 Adipocyte		Cannabinoid Receptor , Akt , Endogenous Metabolite , PPAR
T6817	Deguelin	(-)-Deguelin,(-)-cis-Deguelin	Apoptosis , Akt , PI3K , Autophagy
	Deguelin ((-)-Deguelin) is a PI3K/AKT Inhibitor, which is a natural product isolated from plants in the Mundulea sericea family.		Apoptosis , Akt , PI3K , Autophagy
T3861	Isobavachalcone	Corylifolinin,Isobacachalcone	Apoptosis , Others , Reactive Oxygen Species , Akt , Autophagy
	Isobavachalcone (Corylifolinin) is a chalcone constituent of Angelica keiskei, has potent anti-inflammatory activity, possible can ameliorate neuronal injury in brain diseases associated with inflammation.
TN1405	Arnicolide D		Akt , Caspase , PI3K , STAT , mTOR
	Arnicolide D is a sesquiterpene lactone. Arnicolide D isolates from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling path...		Akt , Caspase , PI3K , STAT , mTOR
T4S0498	Glaucocalyxin A	Wangzaozin B,Leukamenin F	Apoptosis , Akt , Caspase , PI3K
	1. Glaucocalyxin A (Leukamenin F)-SBE-β-CD could be useful with a better solubility and sustained function in drug delivery. 2. Glaucocalyxin A activates caspase-3, decreases BAD phosphorylation, and reduces the expressi...		Apoptosis , Akt , Caspase , PI3K
T3826	Polygalasaponin F		NF-κB , TLR , Akt , PI3K
	Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and reduce the expression of inducible nitric oxide synthases. Po...		NF-κB , TLR , Akt , PI3K
T5S0506	Rotundic acid	Rutundic acid	Apoptosis , Others , p38 MAPK , Akt , mTOR
	Rotundic acid (Rutundic acid), a natural compound, exhibit cytotoxic activities toward human hepatocellular carcinoma (HepG2), malignant melanoma (A375), SCLC (NCI-H446), breast cancer (MCF-7), and colon cancer (HT-29) c...		Apoptosis , Others , p38 MAPK , Akt , mTOR
T3895	Polyphyllin I		Apoptosis , Akt , JNK , PDK , mTOR , Autophagy
	Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C, and cleaved-caspase-3 levels. Polyphyllin D ha...		Apoptosis , Akt , JNK , PDK , mTOR , Autophagy
TN1968	N-Feruloyloctopamine	N-Feruloyloctopamine	p38 MAPK , Akt
	N-Feruloyloctopamine is a natural product.		p38 MAPK , Akt
TN1911	Marein		transporter , Akt , HDAC , AMPK
	Marein shows neuroprotective effect on PC12 cell damage induced by methylglyoxal, which is due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway, it may be a potent compound for ...		transporter , Akt , HDAC , AMPK
T6S0619	Pachymic acid	3-O-Acetyltumulosic acid	ERK , Akt
	Pachymic acid (3-O-Acetyltumulosic acid) is a natural product, and inhibits Akt and ERK signaling pathways.		ERK , Akt
T5740	25(R,S)-Ruscogenin	(25RS)-Ruscogenin	Others , HIF
	25(R,S)-Ruscogenin is a natual product.		Others , HIF
T7912	(−)-Myrtenal	(1R)-(−)-Myrtenal	Others
	(−)-Myrtenal ameliorates hyperglycemia by enhancing GLUT2 through Akt in the skeletal muscle and liver of diabetic rats.		Others
T5574	Guggulsterone	Guggulsterone E&Z	Apoptosis , FXR , Akt , Caspase , JNK , Autophagy
	Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen.		Apoptosis , FXR , Akt , Caspase , JNK , Autophagy
T2851	Daphnetin	7,8-Dihydroxycoumarin,Daphnetol	EGFR , PKA , PKC , Parasite , Autophagy
	Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM), and PKC (IC50: 25.01 μM), also exhibit anti-oxidant and anti-...		EGFR , PKA , PKC , Parasite , Autophagy
T2P2806	Hederacolchiside A1	Raddeanoside R13	Apoptosis , ERK , MEK , Akt , PI3K , Parasite , mTOR
	Hederacolchiside A1 (Raddeanoside R13) shows anti-leishmanial activity, it exhibits a strong antiproliferative activity on all stages of development of the parasite by altering membrane integrity and potential. Hederacol...		Apoptosis , ERK , MEK , Akt , PI3K , Parasite , mTOR
T13265	Urolithin B		ERK , NF-κB , Akt , Endogenous Metabolite , JNK , AMPK
	Urolithin B is one of the gut microbial metabolites of ellagitannins and is found in diverse plant foods, including pomegranates, berries, walnuts, tropical fruits, and medicinal herbs. Urolithin B inhibits NF-κB activit...		ERK , NF-κB , Akt , Endogenous Metabolite , JNK , AMPK
T3001	Honokiol	NSC 293100	ERK , HCV Protease , MEK , Akt , Autophagy
	Honokiol (NSC-293100) is the active principle of magnolia extract. It inhibits the activation of Akt and enhances the phosphorylation of ERK1/ERK2.		ERK , HCV Protease , MEK , Akt , Autophagy
T2789	Scutellarin	Breviscapin,Breviscapinun,Breviscapine,Scutellarein-7-glucuronide	Akt , HIV Protease , STAT
	Scutellarin (Scutellarein-7-glucuronide), an active flavone isolated from Scutellaria baicalensis, can inhibit RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts, and down-regulate the STAT3/Girdin/Akt signal...		Akt , HIV Protease , STAT
T2790	Oridonin	NSC-250682,Rubescenin,Isodonol,Rubescensin A	Akt , Antibacterial
	Oridonin (NSC-250682) is a diterpenoid isolated from Rabdosia rubescens with anti-tumor, anti-bacterial and anti-inflammatory effects. It acts as an inhibitor of AKT, with IC50s of 8.4 and 8.9 μM for AKT1 and AKT2.		Akt , Antibacterial
T4S21320	ISOGINKGETIN	4',4'''-Dimethylamentoflavone	MMP , Others
	1. ISOGINKGETIN (4',4'''-Dimethylamentoflavone), a compound derived from the leaves of Ginkgo biloba, to up-regulate adiponectin secretion with potency comparable to that of rosiglitazone, a known modulator of adiponecti...		MMP , Others
T3P2904	α-Linolenic acid	Alpha-Linolenic Acid,Linolenic acid	Akt , PI3K
	α-Linolenic acid (Alpha-Linolenic Acid) is an essential fatty acid belonging to the omega-3 fatty acids group. It is highly concentrated in certain plant oils and has been reported to inhibit the synthesis of prostagland...		Akt , PI3K
T2974	Cyclovirobuxine D	CVB-D,Bebuxine,Cyclovirobuxin D	Apoptosis , Others , Akt , mTOR , Autophagy
	Cyclovirobuxine D (Bebuxine) is extracted from Buxus microphylla.		Apoptosis , Others , Akt , mTOR , Autophagy
T0392	Artemisinin	Qinghaosu,Artemisinine,Qinghaosu,NSC 369397,Artemisinine	HCV Protease , Ferroptosis , Akt , Parasite
	Artemisinin (Qinghaosu) is an ancient Chinese herbal therapy for malarial fevers which has been recently found to have potent activity against many forms of malarial organisms, including chloroquine-resistant Plasmodium ...		HCV Protease , Ferroptosis , Akt , Parasite
T0518	Methacycline hydrochloride	Rondomycin,Methacycline HCl	ribosome , Antibacterial , Antibiotic
	Methacycline hydrochloride (Rondomycin) is a broad-spectrum semisynthetic antibiotic related to TETRACYCLINE but excreted more slowly and maintaining effective blood levels for a more extended period.		ribosome , Antibacterial , Antibiotic
T2163	Dihydrocapsaicin	CCRIS1589,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide	Others , TRP/TRPV Channel
	Dihydrocapsaicin (CCRIS1589) is isolated from Capsicum fruit. Capsaicin is the primary active component of the heat and pain-eliciting lipid soluble fraction of the Capsicum pepper. Like capsaicin, dihydrocapsaicin is an...		Others , TRP/TRPV Channel
T1205	Chloramphenicol	Chlornitromycin,Levomycetin,Chloromycetin	ribosome , HIF/HIF Prolyl-Hydroxylase , Antibacterial , Antibiotic
	Chloramphenicol (Chloromycetin), a broad-spectrum antibiotic, blocks bacterial protein synthesis.
TN1033	Sennidin A		HCV Protease , transporter , Akt , PI3K
	Sennidin A, has two hydroxyanthraquinone-like moieties, exerts inhibition on NS3 helicase with IC50 values of 0.8 μM.		HCV Protease , transporter , Akt , PI3K
TN1034	Sennidin B		HCV Protease , transporter , Akt , PI3K
	Sennidin B stimulates glucose incorporation in rat adipocytes.		HCV Protease , transporter , Akt , PI3K
T4085	Paris saponin VII	Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII	Apoptosis , BCL , Others , PARP , p38 MAPK , Akt , Caspase , P-gp , Autophagy
	Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.
T5736	1,3-Dicaffeoylquinic acid	CYNARIN,Cyclohexanecarboxylic acid, 1,3-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-4,5-dihydroxy-, (1S,3R,4R,5R)-,1,3-O-Dicaffeoylquinic acid,1,5-Dicaffeoylquinic acid	Reactive Oxygen Species , Akt , PI3K
	1,3-Dicaffeoylquinic acid (CYNARIN) is a natural product. It shows antioxidant and choleretic properties and is a potential immunosuppressive agent.		Reactive Oxygen Species , Akt , PI3K
T4672	Brevilin A		Apoptosis , Anti-infection , JAK , STAT , Autophagy
	Brevilin A is a sesquiterpene lactone isolated from Centipeda minima, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells with anti-tumor activity. Brevilin A is a selective inhibitor of JAK-STAT si...		Apoptosis , Anti-infection , JAK , STAT , Autophagy
T27305	Fascaplysin chloride	NSC622398,NSC 622398,Fascaplysin,NSC-622398
	Fascaplysin is a cyclin D kinase 4/ cyclin D1 inhibitor (IC50 = 0.35 μM). Fascaplysin induces caspase mediated crosstalk between autophagy and apoptosis through the inhibition of PI3K/AKT/mTOR signaling cascade in human ...
TN1504	Citreorosein		cAMP , NF-κB , PI3K
	Citreorosein is a cAMP phosphodiesterase inhibitor, it has anti-inflammatory effect, inhibits proinflammatory cytokines production through the inhibition of both MAPKs and AKT-mediated IκB kinase (IKK) phosphorylation an...		cAMP , NF-κB , PI3K

天然物製品

Crebanine

T2S2215

Synonym:

Target: Apoptosis, Others, Akt

Target: Apoptosis, Akt, JNK, Autophagy

Batatasin III

TN1433

Synonym:

Target: FAK, Others, Akt

Sophocarpine

T6677

Synonym:

Target: ERK, p38 MAPK, NF-κB, TLR, COX, HER, JNK, STAT

Target: Apoptosis, VEGFR, Akt

Deltonin

T3844

Synonym:

Target: ERK, Others, Akt, Endogenous Metabolite

Phellodendrine

T6S0781

Synonym: Phallodendrin

Target: Others, NF-κB, Akt

Sophocarpine monohydrate

T2746

Synonym: Sophocarpine

Target: Apoptosis, Influenza Virus, Akt, PI3K, AMPK, Autophagy

Esculetin

T2798

Synonym: Aesculetin,Cichorigenin

Target: Lipoxygenase, Akt, PI3K

N-Oleoyl glycine

T13803

Synonym:

Target: Cannabinoid Receptor, Akt, Endogenous Metabolite, PPAR

Deguelin

T6817

Synonym: (-)-Deguelin,(-)-cis-Deguelin

Target: Apoptosis, Akt, PI3K, Autophagy

Isobavachalcone

T3861

Synonym: Corylifolinin,Isobacachalcone

Target: Apoptosis, Others, Reactive Oxygen Species, Akt, Autophagy

Arnicolide D

TN1405

Synonym:

Target: Akt, Caspase, PI3K, STAT, mTOR

Glaucocalyxin A

T4S0498

Synonym: Wangzaozin B,Leukamenin F

Target: Apoptosis, Akt, Caspase, PI3K

Polygalasaponin F

T3826

Synonym:

Target: NF-κB, TLR, Akt, PI3K

Rotundic acid

T5S0506

Synonym: Rutundic acid

Target: Apoptosis, Others, p38 MAPK, Akt, mTOR

Polyphyllin I

T3895

Synonym:

Target: Apoptosis, Akt, JNK, PDK, mTOR, Autophagy

N-Feruloyloctopamine

TN1968

Synonym: N-Feruloyloctopamine

Target: p38 MAPK, Akt

Marein

TN1911

Synonym:

Target: transporter, Akt, HDAC, AMPK

Pachymic acid

T6S0619

Synonym: 3-O-Acetyltumulosic acid

Target: ERK, Akt

25(R,S)-Ruscogenin

T5740

Synonym: (25RS)-Ruscogenin

Target: Others, HIF

(−)-Myrtenal

T7912

Synonym: (1R)-(−)-Myrtenal

Target: Others

Guggulsterone

T5574

Synonym: Guggulsterone E&Z

Target: Apoptosis, FXR, Akt, Caspase, JNK, Autophagy

Daphnetin

T2851

Synonym: 7,8-Dihydroxycoumarin,Daphnetol

Target: EGFR, PKA, PKC, Parasite, Autophagy

Hederacolchiside A1

T2P2806

Synonym: Raddeanoside R13

Target: Apoptosis, ERK, MEK, Akt, PI3K, Parasite, mTOR

Urolithin B

T13265

Synonym:

Target: ERK, NF-κB, Akt, Endogenous Metabolite, JNK, AMPK

Honokiol

T3001

Synonym: NSC 293100

Target: ERK, HCV Protease, MEK, Akt, Autophagy

Scutellarin

T2789

Synonym: Breviscapin,Breviscapinun,Breviscapine,Scutellarein-7-glucuronide

Target: Akt, HIV Protease, STAT

Oridonin

T2790

Synonym: NSC-250682,Rubescenin,Isodonol,Rubescensin A

Target: Akt, Antibacterial

ISOGINKGETIN

T4S21320

Synonym: 4',4'''-Dimethylamentoflavone

Target: MMP, Others

α-Linolenic acid

T3P2904

Synonym: Alpha-Linolenic Acid,Linolenic acid

Target: Akt, PI3K

Cyclovirobuxine D

T2974

Synonym: CVB-D,Bebuxine,Cyclovirobuxin D

Target: Apoptosis, Others, Akt, mTOR, Autophagy

Artemisinin

T0392

Synonym: Qinghaosu,Artemisinine,Qinghaosu,NSC 369397,Artemisinine

Target: HCV Protease, Ferroptosis, Akt, Parasite

Methacycline hydrochloride

T0518

Synonym: Rondomycin,Methacycline HCl

Target: ribosome, Antibacterial, Antibiotic

Dihydrocapsaicin

T2163

Synonym: CCRIS1589,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide

Target: Others, TRP/TRPV Channel

Chloramphenicol

T1205

Synonym: Chlornitromycin,Levomycetin,Chloromycetin

Target: ribosome, HIF/HIF Prolyl-Hydroxylase, Antibacterial, Antibiotic

Sennidin A

TN1033

Synonym:

Target: HCV Protease, transporter, Akt, PI3K

Sennidin B

TN1034

Synonym:

Target: HCV Protease, transporter, Akt, PI3K

Paris saponin VII

T4085

Synonym: Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII

Target: Apoptosis, BCL, Others, PARP, p38 MAPK, Akt, Caspase, P-gp, Autophagy

1,3-Dicaffeoylquinic acid

T5736

Synonym: CYNARIN,Cyclohexanecarboxylic acid, 1,3-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-4,5-dihydroxy-, (1S,3R,4R,5R)-,1,3-O-Dicaffeoylquinic acid,1,5-Dicaffeoylquinic acid

Target: Reactive Oxygen Species, Akt, PI3K

Brevilin A

T4672

Synonym:

Target: Apoptosis, Anti-infection, JAK, STAT, Autophagy

Fascaplysin chloride

T27305

Synonym: NSC622398,NSC 622398,Fascaplysin,NSC-622398

Target: cAMP, NF-κB, PI3K

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-04552	AKT1 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	v-akt murine thymoma viral oncogene homolog 1 (AKT1), or protein kinase B-alpha (PKB-ALPHA) is a serine-threonine protein kinase, belonging to the Protein Kinase Superfamily. AKT1 is a major mediator of the responses to ...
TMPY-04461	TRIB3 Protein, Human, Recombinant (GST)	Human	Baculovirus Insect Cells
	Tribbles homolog 3, also known as Neuronal cell death-inducible putative kinase, p65-interacting inhibitor of NF-kappa-B, SINK and TRIB3, is a Nucleus protein that belongs to the protein kinase superfamily and CAMK Ser/T...

AKT1 Protein, Human, Recombinant (His)

TMPY-04552

Species: Human

Expression System: Baculovirus Insect Cells

TRIB3 Protein, Human, Recombinant (GST)

TMPY-04461

Species: Human

Expression System: Baculovirus Insect Cells